Polymorphism analysis of tyrosine hydroxylase gene variable number of tandem repeats in various Korean dogs
Abstract Although humans and canines exhibit similar behavioral features, it is not easy to identify the corresponding behavioral phenotypes. The variable number of tandem repeats (VNTR) in intron 4 of the tyrosine hydroxylase (TH) gene is related to two characteristics, namely, impulsive activity a...
Ausführliche Beschreibung
Autor*in: |
Lee, Hee-Eun [verfasserIn] |
---|
Format: |
E-Artikel |
---|---|
Sprache: |
Englisch |
Erschienen: |
2014 |
---|
Schlagwörter: |
---|
Anmerkung: |
© The Genetics Society of Korea and Springer-Science and Media 2014 |
---|
Übergeordnetes Werk: |
Enthalten in: Genes & Genomics - The Genetics Society of Korea, 2010, 37(2014), 3 vom: 07. Nov., Seite 257-261 |
---|---|
Übergeordnetes Werk: |
volume:37 ; year:2014 ; number:3 ; day:07 ; month:11 ; pages:257-261 |
Links: |
---|
DOI / URN: |
10.1007/s13258-014-0243-4 |
---|
Katalog-ID: |
SPR031101887 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | SPR031101887 | ||
003 | DE-627 | ||
005 | 20230331065804.0 | ||
007 | cr uuu---uuuuu | ||
008 | 201007s2014 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1007/s13258-014-0243-4 |2 doi | |
035 | |a (DE-627)SPR031101887 | ||
035 | |a (SPR)s13258-014-0243-4-e | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Lee, Hee-Eun |e verfasserin |4 aut | |
245 | 1 | 0 | |a Polymorphism analysis of tyrosine hydroxylase gene variable number of tandem repeats in various Korean dogs |
264 | 1 | |c 2014 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
500 | |a © The Genetics Society of Korea and Springer-Science and Media 2014 | ||
520 | |a Abstract Although humans and canines exhibit similar behavioral features, it is not easy to identify the corresponding behavioral phenotypes. The variable number of tandem repeats (VNTR) in intron 4 of the tyrosine hydroxylase (TH) gene is related to two characteristics, namely, impulsive activity and inattention. The TH genes are defined by three genotypes: type 1/1 comprises a single copy of TH VNTR; type 1/2 is heterozygote for both short allele and long allele; and type 2/2 is the doubled form of TH VNTR, which leads to inattention and impulsive actions. The 1/1 and 1/2 genotype have been identified as biomarkers for concentration and impulsive action. Therefore, we performed PCR amplification to detect the 1/2 genotypes in three canine breeds from Korea: Sapsaree (49), Poongsan (18), and Jindo (20). Our results indicate that the Sapsaree dog carries 27 % of the 2/2 genotype, 59 % of the 1/2 genotype, and 14 % of the 1/1 genotype; the Poongsan dog carries 11 % of the 2/2 genotype, 22 % of 1/2 genotype, and 67 % of 1/1 genotype; whereas the Jindo dog carries 10 % of the 2/2 genotype, 40 % of the 1/2 genotype, and 50 % of the 1/1 genotype. Taken together, our data indicate that the Jindo, Poongsan, and Sapsaree dogs harbor decreasing amounts of phenotypes responsible for inattention and impulsive behavior, in that order. Additionally, the Sapsaree genes harbor higher amounts of the 1/2 genotype than the Jindo and Poongsan genes, respectively. | ||
650 | 4 | |a Korean dog breeds |7 (dpeaa)DE-He213 | |
650 | 4 | |a Military working dogs |7 (dpeaa)DE-He213 | |
650 | 4 | |a Polymorphism |7 (dpeaa)DE-He213 | |
650 | 4 | |a Tyrosine hydroxylase |7 (dpeaa)DE-He213 | |
650 | 4 | |a Variable number of tandem repeats |7 (dpeaa)DE-He213 | |
700 | 1 | |a Choi, Bong-Hwan |4 aut | |
700 | 1 | |a Lee, Dong-Hoon |4 aut | |
700 | 1 | |a Kwon, Yun-Jeong |4 aut | |
700 | 1 | |a Eo, Jungwoo |4 aut | |
700 | 1 | |a Choi, Yuri |4 aut | |
700 | 1 | |a Jeong, Hoim |4 aut | |
700 | 1 | |a Gim, Jeong-An |4 aut | |
700 | 1 | |a Kim, Tae-Hun |4 aut | |
700 | 1 | |a Ha, Ji-Hong |4 aut | |
700 | 1 | |a Han, Kook-Il |4 aut | |
700 | 1 | |a Kim, Heui-Soo |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Genes & Genomics |d The Genetics Society of Korea, 2010 |g 37(2014), 3 vom: 07. Nov., Seite 257-261 |w (DE-627)SPR031096425 |7 nnns |
773 | 1 | 8 | |g volume:37 |g year:2014 |g number:3 |g day:07 |g month:11 |g pages:257-261 |
856 | 4 | 0 | |u https://dx.doi.org/10.1007/s13258-014-0243-4 |z lizenzpflichtig |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a SYSFLAG_A | ||
912 | |a GBV_SPRINGER | ||
951 | |a AR | ||
952 | |d 37 |j 2014 |e 3 |b 07 |c 11 |h 257-261 |
author_variant |
h e l hel b h c bhc d h l dhl y j k yjk j e je y c yc h j hj j a g jag t h k thk j h h jhh k i h kih h s k hsk |
---|---|
matchkey_str |
leeheeeunchoibonghwanleedonghoonkwonyunj:2014----:oyopimnlssfyoieyrxlsgnvralnmeotner |
hierarchy_sort_str |
2014 |
publishDate |
2014 |
allfields |
10.1007/s13258-014-0243-4 doi (DE-627)SPR031101887 (SPR)s13258-014-0243-4-e DE-627 ger DE-627 rakwb eng Lee, Hee-Eun verfasserin aut Polymorphism analysis of tyrosine hydroxylase gene variable number of tandem repeats in various Korean dogs 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Genetics Society of Korea and Springer-Science and Media 2014 Abstract Although humans and canines exhibit similar behavioral features, it is not easy to identify the corresponding behavioral phenotypes. The variable number of tandem repeats (VNTR) in intron 4 of the tyrosine hydroxylase (TH) gene is related to two characteristics, namely, impulsive activity and inattention. The TH genes are defined by three genotypes: type 1/1 comprises a single copy of TH VNTR; type 1/2 is heterozygote for both short allele and long allele; and type 2/2 is the doubled form of TH VNTR, which leads to inattention and impulsive actions. The 1/1 and 1/2 genotype have been identified as biomarkers for concentration and impulsive action. Therefore, we performed PCR amplification to detect the 1/2 genotypes in three canine breeds from Korea: Sapsaree (49), Poongsan (18), and Jindo (20). Our results indicate that the Sapsaree dog carries 27 % of the 2/2 genotype, 59 % of the 1/2 genotype, and 14 % of the 1/1 genotype; the Poongsan dog carries 11 % of the 2/2 genotype, 22 % of 1/2 genotype, and 67 % of 1/1 genotype; whereas the Jindo dog carries 10 % of the 2/2 genotype, 40 % of the 1/2 genotype, and 50 % of the 1/1 genotype. Taken together, our data indicate that the Jindo, Poongsan, and Sapsaree dogs harbor decreasing amounts of phenotypes responsible for inattention and impulsive behavior, in that order. Additionally, the Sapsaree genes harbor higher amounts of the 1/2 genotype than the Jindo and Poongsan genes, respectively. Korean dog breeds (dpeaa)DE-He213 Military working dogs (dpeaa)DE-He213 Polymorphism (dpeaa)DE-He213 Tyrosine hydroxylase (dpeaa)DE-He213 Variable number of tandem repeats (dpeaa)DE-He213 Choi, Bong-Hwan aut Lee, Dong-Hoon aut Kwon, Yun-Jeong aut Eo, Jungwoo aut Choi, Yuri aut Jeong, Hoim aut Gim, Jeong-An aut Kim, Tae-Hun aut Ha, Ji-Hong aut Han, Kook-Il aut Kim, Heui-Soo aut Enthalten in Genes & Genomics The Genetics Society of Korea, 2010 37(2014), 3 vom: 07. Nov., Seite 257-261 (DE-627)SPR031096425 nnns volume:37 year:2014 number:3 day:07 month:11 pages:257-261 https://dx.doi.org/10.1007/s13258-014-0243-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 37 2014 3 07 11 257-261 |
spelling |
10.1007/s13258-014-0243-4 doi (DE-627)SPR031101887 (SPR)s13258-014-0243-4-e DE-627 ger DE-627 rakwb eng Lee, Hee-Eun verfasserin aut Polymorphism analysis of tyrosine hydroxylase gene variable number of tandem repeats in various Korean dogs 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Genetics Society of Korea and Springer-Science and Media 2014 Abstract Although humans and canines exhibit similar behavioral features, it is not easy to identify the corresponding behavioral phenotypes. The variable number of tandem repeats (VNTR) in intron 4 of the tyrosine hydroxylase (TH) gene is related to two characteristics, namely, impulsive activity and inattention. The TH genes are defined by three genotypes: type 1/1 comprises a single copy of TH VNTR; type 1/2 is heterozygote for both short allele and long allele; and type 2/2 is the doubled form of TH VNTR, which leads to inattention and impulsive actions. The 1/1 and 1/2 genotype have been identified as biomarkers for concentration and impulsive action. Therefore, we performed PCR amplification to detect the 1/2 genotypes in three canine breeds from Korea: Sapsaree (49), Poongsan (18), and Jindo (20). Our results indicate that the Sapsaree dog carries 27 % of the 2/2 genotype, 59 % of the 1/2 genotype, and 14 % of the 1/1 genotype; the Poongsan dog carries 11 % of the 2/2 genotype, 22 % of 1/2 genotype, and 67 % of 1/1 genotype; whereas the Jindo dog carries 10 % of the 2/2 genotype, 40 % of the 1/2 genotype, and 50 % of the 1/1 genotype. Taken together, our data indicate that the Jindo, Poongsan, and Sapsaree dogs harbor decreasing amounts of phenotypes responsible for inattention and impulsive behavior, in that order. Additionally, the Sapsaree genes harbor higher amounts of the 1/2 genotype than the Jindo and Poongsan genes, respectively. Korean dog breeds (dpeaa)DE-He213 Military working dogs (dpeaa)DE-He213 Polymorphism (dpeaa)DE-He213 Tyrosine hydroxylase (dpeaa)DE-He213 Variable number of tandem repeats (dpeaa)DE-He213 Choi, Bong-Hwan aut Lee, Dong-Hoon aut Kwon, Yun-Jeong aut Eo, Jungwoo aut Choi, Yuri aut Jeong, Hoim aut Gim, Jeong-An aut Kim, Tae-Hun aut Ha, Ji-Hong aut Han, Kook-Il aut Kim, Heui-Soo aut Enthalten in Genes & Genomics The Genetics Society of Korea, 2010 37(2014), 3 vom: 07. Nov., Seite 257-261 (DE-627)SPR031096425 nnns volume:37 year:2014 number:3 day:07 month:11 pages:257-261 https://dx.doi.org/10.1007/s13258-014-0243-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 37 2014 3 07 11 257-261 |
allfields_unstemmed |
10.1007/s13258-014-0243-4 doi (DE-627)SPR031101887 (SPR)s13258-014-0243-4-e DE-627 ger DE-627 rakwb eng Lee, Hee-Eun verfasserin aut Polymorphism analysis of tyrosine hydroxylase gene variable number of tandem repeats in various Korean dogs 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Genetics Society of Korea and Springer-Science and Media 2014 Abstract Although humans and canines exhibit similar behavioral features, it is not easy to identify the corresponding behavioral phenotypes. The variable number of tandem repeats (VNTR) in intron 4 of the tyrosine hydroxylase (TH) gene is related to two characteristics, namely, impulsive activity and inattention. The TH genes are defined by three genotypes: type 1/1 comprises a single copy of TH VNTR; type 1/2 is heterozygote for both short allele and long allele; and type 2/2 is the doubled form of TH VNTR, which leads to inattention and impulsive actions. The 1/1 and 1/2 genotype have been identified as biomarkers for concentration and impulsive action. Therefore, we performed PCR amplification to detect the 1/2 genotypes in three canine breeds from Korea: Sapsaree (49), Poongsan (18), and Jindo (20). Our results indicate that the Sapsaree dog carries 27 % of the 2/2 genotype, 59 % of the 1/2 genotype, and 14 % of the 1/1 genotype; the Poongsan dog carries 11 % of the 2/2 genotype, 22 % of 1/2 genotype, and 67 % of 1/1 genotype; whereas the Jindo dog carries 10 % of the 2/2 genotype, 40 % of the 1/2 genotype, and 50 % of the 1/1 genotype. Taken together, our data indicate that the Jindo, Poongsan, and Sapsaree dogs harbor decreasing amounts of phenotypes responsible for inattention and impulsive behavior, in that order. Additionally, the Sapsaree genes harbor higher amounts of the 1/2 genotype than the Jindo and Poongsan genes, respectively. Korean dog breeds (dpeaa)DE-He213 Military working dogs (dpeaa)DE-He213 Polymorphism (dpeaa)DE-He213 Tyrosine hydroxylase (dpeaa)DE-He213 Variable number of tandem repeats (dpeaa)DE-He213 Choi, Bong-Hwan aut Lee, Dong-Hoon aut Kwon, Yun-Jeong aut Eo, Jungwoo aut Choi, Yuri aut Jeong, Hoim aut Gim, Jeong-An aut Kim, Tae-Hun aut Ha, Ji-Hong aut Han, Kook-Il aut Kim, Heui-Soo aut Enthalten in Genes & Genomics The Genetics Society of Korea, 2010 37(2014), 3 vom: 07. Nov., Seite 257-261 (DE-627)SPR031096425 nnns volume:37 year:2014 number:3 day:07 month:11 pages:257-261 https://dx.doi.org/10.1007/s13258-014-0243-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 37 2014 3 07 11 257-261 |
allfieldsGer |
10.1007/s13258-014-0243-4 doi (DE-627)SPR031101887 (SPR)s13258-014-0243-4-e DE-627 ger DE-627 rakwb eng Lee, Hee-Eun verfasserin aut Polymorphism analysis of tyrosine hydroxylase gene variable number of tandem repeats in various Korean dogs 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Genetics Society of Korea and Springer-Science and Media 2014 Abstract Although humans and canines exhibit similar behavioral features, it is not easy to identify the corresponding behavioral phenotypes. The variable number of tandem repeats (VNTR) in intron 4 of the tyrosine hydroxylase (TH) gene is related to two characteristics, namely, impulsive activity and inattention. The TH genes are defined by three genotypes: type 1/1 comprises a single copy of TH VNTR; type 1/2 is heterozygote for both short allele and long allele; and type 2/2 is the doubled form of TH VNTR, which leads to inattention and impulsive actions. The 1/1 and 1/2 genotype have been identified as biomarkers for concentration and impulsive action. Therefore, we performed PCR amplification to detect the 1/2 genotypes in three canine breeds from Korea: Sapsaree (49), Poongsan (18), and Jindo (20). Our results indicate that the Sapsaree dog carries 27 % of the 2/2 genotype, 59 % of the 1/2 genotype, and 14 % of the 1/1 genotype; the Poongsan dog carries 11 % of the 2/2 genotype, 22 % of 1/2 genotype, and 67 % of 1/1 genotype; whereas the Jindo dog carries 10 % of the 2/2 genotype, 40 % of the 1/2 genotype, and 50 % of the 1/1 genotype. Taken together, our data indicate that the Jindo, Poongsan, and Sapsaree dogs harbor decreasing amounts of phenotypes responsible for inattention and impulsive behavior, in that order. Additionally, the Sapsaree genes harbor higher amounts of the 1/2 genotype than the Jindo and Poongsan genes, respectively. Korean dog breeds (dpeaa)DE-He213 Military working dogs (dpeaa)DE-He213 Polymorphism (dpeaa)DE-He213 Tyrosine hydroxylase (dpeaa)DE-He213 Variable number of tandem repeats (dpeaa)DE-He213 Choi, Bong-Hwan aut Lee, Dong-Hoon aut Kwon, Yun-Jeong aut Eo, Jungwoo aut Choi, Yuri aut Jeong, Hoim aut Gim, Jeong-An aut Kim, Tae-Hun aut Ha, Ji-Hong aut Han, Kook-Il aut Kim, Heui-Soo aut Enthalten in Genes & Genomics The Genetics Society of Korea, 2010 37(2014), 3 vom: 07. Nov., Seite 257-261 (DE-627)SPR031096425 nnns volume:37 year:2014 number:3 day:07 month:11 pages:257-261 https://dx.doi.org/10.1007/s13258-014-0243-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 37 2014 3 07 11 257-261 |
allfieldsSound |
10.1007/s13258-014-0243-4 doi (DE-627)SPR031101887 (SPR)s13258-014-0243-4-e DE-627 ger DE-627 rakwb eng Lee, Hee-Eun verfasserin aut Polymorphism analysis of tyrosine hydroxylase gene variable number of tandem repeats in various Korean dogs 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Genetics Society of Korea and Springer-Science and Media 2014 Abstract Although humans and canines exhibit similar behavioral features, it is not easy to identify the corresponding behavioral phenotypes. The variable number of tandem repeats (VNTR) in intron 4 of the tyrosine hydroxylase (TH) gene is related to two characteristics, namely, impulsive activity and inattention. The TH genes are defined by three genotypes: type 1/1 comprises a single copy of TH VNTR; type 1/2 is heterozygote for both short allele and long allele; and type 2/2 is the doubled form of TH VNTR, which leads to inattention and impulsive actions. The 1/1 and 1/2 genotype have been identified as biomarkers for concentration and impulsive action. Therefore, we performed PCR amplification to detect the 1/2 genotypes in three canine breeds from Korea: Sapsaree (49), Poongsan (18), and Jindo (20). Our results indicate that the Sapsaree dog carries 27 % of the 2/2 genotype, 59 % of the 1/2 genotype, and 14 % of the 1/1 genotype; the Poongsan dog carries 11 % of the 2/2 genotype, 22 % of 1/2 genotype, and 67 % of 1/1 genotype; whereas the Jindo dog carries 10 % of the 2/2 genotype, 40 % of the 1/2 genotype, and 50 % of the 1/1 genotype. Taken together, our data indicate that the Jindo, Poongsan, and Sapsaree dogs harbor decreasing amounts of phenotypes responsible for inattention and impulsive behavior, in that order. Additionally, the Sapsaree genes harbor higher amounts of the 1/2 genotype than the Jindo and Poongsan genes, respectively. Korean dog breeds (dpeaa)DE-He213 Military working dogs (dpeaa)DE-He213 Polymorphism (dpeaa)DE-He213 Tyrosine hydroxylase (dpeaa)DE-He213 Variable number of tandem repeats (dpeaa)DE-He213 Choi, Bong-Hwan aut Lee, Dong-Hoon aut Kwon, Yun-Jeong aut Eo, Jungwoo aut Choi, Yuri aut Jeong, Hoim aut Gim, Jeong-An aut Kim, Tae-Hun aut Ha, Ji-Hong aut Han, Kook-Il aut Kim, Heui-Soo aut Enthalten in Genes & Genomics The Genetics Society of Korea, 2010 37(2014), 3 vom: 07. Nov., Seite 257-261 (DE-627)SPR031096425 nnns volume:37 year:2014 number:3 day:07 month:11 pages:257-261 https://dx.doi.org/10.1007/s13258-014-0243-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 37 2014 3 07 11 257-261 |
language |
English |
source |
Enthalten in Genes & Genomics 37(2014), 3 vom: 07. Nov., Seite 257-261 volume:37 year:2014 number:3 day:07 month:11 pages:257-261 |
sourceStr |
Enthalten in Genes & Genomics 37(2014), 3 vom: 07. Nov., Seite 257-261 volume:37 year:2014 number:3 day:07 month:11 pages:257-261 |
format_phy_str_mv |
Article |
institution |
findex.gbv.de |
topic_facet |
Korean dog breeds Military working dogs Polymorphism Tyrosine hydroxylase Variable number of tandem repeats |
isfreeaccess_bool |
false |
container_title |
Genes & Genomics |
authorswithroles_txt_mv |
Lee, Hee-Eun @@aut@@ Choi, Bong-Hwan @@aut@@ Lee, Dong-Hoon @@aut@@ Kwon, Yun-Jeong @@aut@@ Eo, Jungwoo @@aut@@ Choi, Yuri @@aut@@ Jeong, Hoim @@aut@@ Gim, Jeong-An @@aut@@ Kim, Tae-Hun @@aut@@ Ha, Ji-Hong @@aut@@ Han, Kook-Il @@aut@@ Kim, Heui-Soo @@aut@@ |
publishDateDaySort_date |
2014-11-07T00:00:00Z |
hierarchy_top_id |
SPR031096425 |
id |
SPR031101887 |
language_de |
englisch |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR031101887</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230331065804.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201007s2014 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s13258-014-0243-4</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR031101887</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s13258-014-0243-4-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Lee, Hee-Eun</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Polymorphism analysis of tyrosine hydroxylase gene variable number of tandem repeats in various Korean dogs</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2014</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Genetics Society of Korea and Springer-Science and Media 2014</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Although humans and canines exhibit similar behavioral features, it is not easy to identify the corresponding behavioral phenotypes. The variable number of tandem repeats (VNTR) in intron 4 of the tyrosine hydroxylase (TH) gene is related to two characteristics, namely, impulsive activity and inattention. The TH genes are defined by three genotypes: type 1/1 comprises a single copy of TH VNTR; type 1/2 is heterozygote for both short allele and long allele; and type 2/2 is the doubled form of TH VNTR, which leads to inattention and impulsive actions. The 1/1 and 1/2 genotype have been identified as biomarkers for concentration and impulsive action. Therefore, we performed PCR amplification to detect the 1/2 genotypes in three canine breeds from Korea: Sapsaree (49), Poongsan (18), and Jindo (20). Our results indicate that the Sapsaree dog carries 27 % of the 2/2 genotype, 59 % of the 1/2 genotype, and 14 % of the 1/1 genotype; the Poongsan dog carries 11 % of the 2/2 genotype, 22 % of 1/2 genotype, and 67 % of 1/1 genotype; whereas the Jindo dog carries 10 % of the 2/2 genotype, 40 % of the 1/2 genotype, and 50 % of the 1/1 genotype. Taken together, our data indicate that the Jindo, Poongsan, and Sapsaree dogs harbor decreasing amounts of phenotypes responsible for inattention and impulsive behavior, in that order. Additionally, the Sapsaree genes harbor higher amounts of the 1/2 genotype than the Jindo and Poongsan genes, respectively.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Korean dog breeds</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Military working dogs</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Polymorphism</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Tyrosine hydroxylase</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Variable number of tandem repeats</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Choi, Bong-Hwan</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lee, Dong-Hoon</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kwon, Yun-Jeong</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Eo, Jungwoo</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Choi, Yuri</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Jeong, Hoim</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gim, Jeong-An</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kim, Tae-Hun</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ha, Ji-Hong</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Han, Kook-Il</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kim, Heui-Soo</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Genes & Genomics</subfield><subfield code="d">The Genetics Society of Korea, 2010</subfield><subfield code="g">37(2014), 3 vom: 07. Nov., Seite 257-261</subfield><subfield code="w">(DE-627)SPR031096425</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:37</subfield><subfield code="g">year:2014</subfield><subfield code="g">number:3</subfield><subfield code="g">day:07</subfield><subfield code="g">month:11</subfield><subfield code="g">pages:257-261</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1007/s13258-014-0243-4</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">37</subfield><subfield code="j">2014</subfield><subfield code="e">3</subfield><subfield code="b">07</subfield><subfield code="c">11</subfield><subfield code="h">257-261</subfield></datafield></record></collection>
|
author |
Lee, Hee-Eun |
spellingShingle |
Lee, Hee-Eun misc Korean dog breeds misc Military working dogs misc Polymorphism misc Tyrosine hydroxylase misc Variable number of tandem repeats Polymorphism analysis of tyrosine hydroxylase gene variable number of tandem repeats in various Korean dogs |
authorStr |
Lee, Hee-Eun |
ppnlink_with_tag_str_mv |
@@773@@(DE-627)SPR031096425 |
format |
electronic Article |
delete_txt_mv |
keep |
author_role |
aut aut aut aut aut aut aut aut aut aut aut aut |
collection |
springer |
remote_str |
true |
illustrated |
Not Illustrated |
topic_title |
Polymorphism analysis of tyrosine hydroxylase gene variable number of tandem repeats in various Korean dogs Korean dog breeds (dpeaa)DE-He213 Military working dogs (dpeaa)DE-He213 Polymorphism (dpeaa)DE-He213 Tyrosine hydroxylase (dpeaa)DE-He213 Variable number of tandem repeats (dpeaa)DE-He213 |
topic |
misc Korean dog breeds misc Military working dogs misc Polymorphism misc Tyrosine hydroxylase misc Variable number of tandem repeats |
topic_unstemmed |
misc Korean dog breeds misc Military working dogs misc Polymorphism misc Tyrosine hydroxylase misc Variable number of tandem repeats |
topic_browse |
misc Korean dog breeds misc Military working dogs misc Polymorphism misc Tyrosine hydroxylase misc Variable number of tandem repeats |
format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
format_main_str_mv |
Text Zeitschrift/Artikel |
carriertype_str_mv |
cr |
hierarchy_parent_title |
Genes & Genomics |
hierarchy_parent_id |
SPR031096425 |
hierarchy_top_title |
Genes & Genomics |
isfreeaccess_txt |
false |
familylinks_str_mv |
(DE-627)SPR031096425 |
title |
Polymorphism analysis of tyrosine hydroxylase gene variable number of tandem repeats in various Korean dogs |
ctrlnum |
(DE-627)SPR031101887 (SPR)s13258-014-0243-4-e |
title_full |
Polymorphism analysis of tyrosine hydroxylase gene variable number of tandem repeats in various Korean dogs |
author_sort |
Lee, Hee-Eun |
journal |
Genes & Genomics |
journalStr |
Genes & Genomics |
lang_code |
eng |
isOA_bool |
false |
recordtype |
marc |
publishDateSort |
2014 |
contenttype_str_mv |
txt |
container_start_page |
257 |
author_browse |
Lee, Hee-Eun Choi, Bong-Hwan Lee, Dong-Hoon Kwon, Yun-Jeong Eo, Jungwoo Choi, Yuri Jeong, Hoim Gim, Jeong-An Kim, Tae-Hun Ha, Ji-Hong Han, Kook-Il Kim, Heui-Soo |
container_volume |
37 |
format_se |
Elektronische Aufsätze |
author-letter |
Lee, Hee-Eun |
doi_str_mv |
10.1007/s13258-014-0243-4 |
title_sort |
polymorphism analysis of tyrosine hydroxylase gene variable number of tandem repeats in various korean dogs |
title_auth |
Polymorphism analysis of tyrosine hydroxylase gene variable number of tandem repeats in various Korean dogs |
abstract |
Abstract Although humans and canines exhibit similar behavioral features, it is not easy to identify the corresponding behavioral phenotypes. The variable number of tandem repeats (VNTR) in intron 4 of the tyrosine hydroxylase (TH) gene is related to two characteristics, namely, impulsive activity and inattention. The TH genes are defined by three genotypes: type 1/1 comprises a single copy of TH VNTR; type 1/2 is heterozygote for both short allele and long allele; and type 2/2 is the doubled form of TH VNTR, which leads to inattention and impulsive actions. The 1/1 and 1/2 genotype have been identified as biomarkers for concentration and impulsive action. Therefore, we performed PCR amplification to detect the 1/2 genotypes in three canine breeds from Korea: Sapsaree (49), Poongsan (18), and Jindo (20). Our results indicate that the Sapsaree dog carries 27 % of the 2/2 genotype, 59 % of the 1/2 genotype, and 14 % of the 1/1 genotype; the Poongsan dog carries 11 % of the 2/2 genotype, 22 % of 1/2 genotype, and 67 % of 1/1 genotype; whereas the Jindo dog carries 10 % of the 2/2 genotype, 40 % of the 1/2 genotype, and 50 % of the 1/1 genotype. Taken together, our data indicate that the Jindo, Poongsan, and Sapsaree dogs harbor decreasing amounts of phenotypes responsible for inattention and impulsive behavior, in that order. Additionally, the Sapsaree genes harbor higher amounts of the 1/2 genotype than the Jindo and Poongsan genes, respectively. © The Genetics Society of Korea and Springer-Science and Media 2014 |
abstractGer |
Abstract Although humans and canines exhibit similar behavioral features, it is not easy to identify the corresponding behavioral phenotypes. The variable number of tandem repeats (VNTR) in intron 4 of the tyrosine hydroxylase (TH) gene is related to two characteristics, namely, impulsive activity and inattention. The TH genes are defined by three genotypes: type 1/1 comprises a single copy of TH VNTR; type 1/2 is heterozygote for both short allele and long allele; and type 2/2 is the doubled form of TH VNTR, which leads to inattention and impulsive actions. The 1/1 and 1/2 genotype have been identified as biomarkers for concentration and impulsive action. Therefore, we performed PCR amplification to detect the 1/2 genotypes in three canine breeds from Korea: Sapsaree (49), Poongsan (18), and Jindo (20). Our results indicate that the Sapsaree dog carries 27 % of the 2/2 genotype, 59 % of the 1/2 genotype, and 14 % of the 1/1 genotype; the Poongsan dog carries 11 % of the 2/2 genotype, 22 % of 1/2 genotype, and 67 % of 1/1 genotype; whereas the Jindo dog carries 10 % of the 2/2 genotype, 40 % of the 1/2 genotype, and 50 % of the 1/1 genotype. Taken together, our data indicate that the Jindo, Poongsan, and Sapsaree dogs harbor decreasing amounts of phenotypes responsible for inattention and impulsive behavior, in that order. Additionally, the Sapsaree genes harbor higher amounts of the 1/2 genotype than the Jindo and Poongsan genes, respectively. © The Genetics Society of Korea and Springer-Science and Media 2014 |
abstract_unstemmed |
Abstract Although humans and canines exhibit similar behavioral features, it is not easy to identify the corresponding behavioral phenotypes. The variable number of tandem repeats (VNTR) in intron 4 of the tyrosine hydroxylase (TH) gene is related to two characteristics, namely, impulsive activity and inattention. The TH genes are defined by three genotypes: type 1/1 comprises a single copy of TH VNTR; type 1/2 is heterozygote for both short allele and long allele; and type 2/2 is the doubled form of TH VNTR, which leads to inattention and impulsive actions. The 1/1 and 1/2 genotype have been identified as biomarkers for concentration and impulsive action. Therefore, we performed PCR amplification to detect the 1/2 genotypes in three canine breeds from Korea: Sapsaree (49), Poongsan (18), and Jindo (20). Our results indicate that the Sapsaree dog carries 27 % of the 2/2 genotype, 59 % of the 1/2 genotype, and 14 % of the 1/1 genotype; the Poongsan dog carries 11 % of the 2/2 genotype, 22 % of 1/2 genotype, and 67 % of 1/1 genotype; whereas the Jindo dog carries 10 % of the 2/2 genotype, 40 % of the 1/2 genotype, and 50 % of the 1/1 genotype. Taken together, our data indicate that the Jindo, Poongsan, and Sapsaree dogs harbor decreasing amounts of phenotypes responsible for inattention and impulsive behavior, in that order. Additionally, the Sapsaree genes harbor higher amounts of the 1/2 genotype than the Jindo and Poongsan genes, respectively. © The Genetics Society of Korea and Springer-Science and Media 2014 |
collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER |
container_issue |
3 |
title_short |
Polymorphism analysis of tyrosine hydroxylase gene variable number of tandem repeats in various Korean dogs |
url |
https://dx.doi.org/10.1007/s13258-014-0243-4 |
remote_bool |
true |
author2 |
Choi, Bong-Hwan Lee, Dong-Hoon Kwon, Yun-Jeong Eo, Jungwoo Choi, Yuri Jeong, Hoim Gim, Jeong-An Kim, Tae-Hun Ha, Ji-Hong Han, Kook-Il Kim, Heui-Soo |
author2Str |
Choi, Bong-Hwan Lee, Dong-Hoon Kwon, Yun-Jeong Eo, Jungwoo Choi, Yuri Jeong, Hoim Gim, Jeong-An Kim, Tae-Hun Ha, Ji-Hong Han, Kook-Il Kim, Heui-Soo |
ppnlink |
SPR031096425 |
mediatype_str_mv |
c |
isOA_txt |
false |
hochschulschrift_bool |
false |
doi_str |
10.1007/s13258-014-0243-4 |
up_date |
2024-07-03T21:59:07.581Z |
_version_ |
1803596802378694656 |
fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR031101887</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230331065804.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201007s2014 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s13258-014-0243-4</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR031101887</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s13258-014-0243-4-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Lee, Hee-Eun</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Polymorphism analysis of tyrosine hydroxylase gene variable number of tandem repeats in various Korean dogs</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2014</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Genetics Society of Korea and Springer-Science and Media 2014</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Although humans and canines exhibit similar behavioral features, it is not easy to identify the corresponding behavioral phenotypes. The variable number of tandem repeats (VNTR) in intron 4 of the tyrosine hydroxylase (TH) gene is related to two characteristics, namely, impulsive activity and inattention. The TH genes are defined by three genotypes: type 1/1 comprises a single copy of TH VNTR; type 1/2 is heterozygote for both short allele and long allele; and type 2/2 is the doubled form of TH VNTR, which leads to inattention and impulsive actions. The 1/1 and 1/2 genotype have been identified as biomarkers for concentration and impulsive action. Therefore, we performed PCR amplification to detect the 1/2 genotypes in three canine breeds from Korea: Sapsaree (49), Poongsan (18), and Jindo (20). Our results indicate that the Sapsaree dog carries 27 % of the 2/2 genotype, 59 % of the 1/2 genotype, and 14 % of the 1/1 genotype; the Poongsan dog carries 11 % of the 2/2 genotype, 22 % of 1/2 genotype, and 67 % of 1/1 genotype; whereas the Jindo dog carries 10 % of the 2/2 genotype, 40 % of the 1/2 genotype, and 50 % of the 1/1 genotype. Taken together, our data indicate that the Jindo, Poongsan, and Sapsaree dogs harbor decreasing amounts of phenotypes responsible for inattention and impulsive behavior, in that order. Additionally, the Sapsaree genes harbor higher amounts of the 1/2 genotype than the Jindo and Poongsan genes, respectively.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Korean dog breeds</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Military working dogs</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Polymorphism</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Tyrosine hydroxylase</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Variable number of tandem repeats</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Choi, Bong-Hwan</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lee, Dong-Hoon</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kwon, Yun-Jeong</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Eo, Jungwoo</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Choi, Yuri</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Jeong, Hoim</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gim, Jeong-An</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kim, Tae-Hun</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ha, Ji-Hong</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Han, Kook-Il</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kim, Heui-Soo</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Genes & Genomics</subfield><subfield code="d">The Genetics Society of Korea, 2010</subfield><subfield code="g">37(2014), 3 vom: 07. Nov., Seite 257-261</subfield><subfield code="w">(DE-627)SPR031096425</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:37</subfield><subfield code="g">year:2014</subfield><subfield code="g">number:3</subfield><subfield code="g">day:07</subfield><subfield code="g">month:11</subfield><subfield code="g">pages:257-261</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1007/s13258-014-0243-4</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">37</subfield><subfield code="j">2014</subfield><subfield code="e">3</subfield><subfield code="b">07</subfield><subfield code="c">11</subfield><subfield code="h">257-261</subfield></datafield></record></collection>
|
score |
7.400443 |