Polymorphism analysis of tyrosine hydroxylase gene variable number of tandem repeats in various Korean dogs
Abstract Although humans and canines exhibit similar behavioral features, it is not easy to identify the corresponding behavioral phenotypes. The variable number of tandem repeats (VNTR) in intron 4 of the tyrosine hydroxylase (TH) gene is related to two characteristics, namely, impulsive activity a...
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| Autor*in: |
Lee, Hee-Eun [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Schlagwörter: |
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| Anmerkung: |
© The Genetics Society of Korea and Springer-Science and Media 2014 |
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| Übergeordnetes Werk: |
Enthalten in: Genes & Genomics - The Genetics Society of Korea, 2010, 37(2014), 3 vom: 07. Nov., Seite 257-261 |
|---|---|
| Übergeordnetes Werk: |
volume:37 ; year:2014 ; number:3 ; day:07 ; month:11 ; pages:257-261 |
| Links: |
|---|
| DOI / URN: |
10.1007/s13258-014-0243-4 |
|---|
| Katalog-ID: |
SPR031101887 |
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| 520 | |a Abstract Although humans and canines exhibit similar behavioral features, it is not easy to identify the corresponding behavioral phenotypes. The variable number of tandem repeats (VNTR) in intron 4 of the tyrosine hydroxylase (TH) gene is related to two characteristics, namely, impulsive activity and inattention. The TH genes are defined by three genotypes: type 1/1 comprises a single copy of TH VNTR; type 1/2 is heterozygote for both short allele and long allele; and type 2/2 is the doubled form of TH VNTR, which leads to inattention and impulsive actions. The 1/1 and 1/2 genotype have been identified as biomarkers for concentration and impulsive action. Therefore, we performed PCR amplification to detect the 1/2 genotypes in three canine breeds from Korea: Sapsaree (49), Poongsan (18), and Jindo (20). Our results indicate that the Sapsaree dog carries 27 % of the 2/2 genotype, 59 % of the 1/2 genotype, and 14 % of the 1/1 genotype; the Poongsan dog carries 11 % of the 2/2 genotype, 22 % of 1/2 genotype, and 67 % of 1/1 genotype; whereas the Jindo dog carries 10 % of the 2/2 genotype, 40 % of the 1/2 genotype, and 50 % of the 1/1 genotype. Taken together, our data indicate that the Jindo, Poongsan, and Sapsaree dogs harbor decreasing amounts of phenotypes responsible for inattention and impulsive behavior, in that order. Additionally, the Sapsaree genes harbor higher amounts of the 1/2 genotype than the Jindo and Poongsan genes, respectively. | ||
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10.1007/s13258-014-0243-4 doi (DE-627)SPR031101887 (SPR)s13258-014-0243-4-e DE-627 ger DE-627 rakwb eng Lee, Hee-Eun verfasserin aut Polymorphism analysis of tyrosine hydroxylase gene variable number of tandem repeats in various Korean dogs 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Genetics Society of Korea and Springer-Science and Media 2014 Abstract Although humans and canines exhibit similar behavioral features, it is not easy to identify the corresponding behavioral phenotypes. The variable number of tandem repeats (VNTR) in intron 4 of the tyrosine hydroxylase (TH) gene is related to two characteristics, namely, impulsive activity and inattention. The TH genes are defined by three genotypes: type 1/1 comprises a single copy of TH VNTR; type 1/2 is heterozygote for both short allele and long allele; and type 2/2 is the doubled form of TH VNTR, which leads to inattention and impulsive actions. The 1/1 and 1/2 genotype have been identified as biomarkers for concentration and impulsive action. Therefore, we performed PCR amplification to detect the 1/2 genotypes in three canine breeds from Korea: Sapsaree (49), Poongsan (18), and Jindo (20). Our results indicate that the Sapsaree dog carries 27 % of the 2/2 genotype, 59 % of the 1/2 genotype, and 14 % of the 1/1 genotype; the Poongsan dog carries 11 % of the 2/2 genotype, 22 % of 1/2 genotype, and 67 % of 1/1 genotype; whereas the Jindo dog carries 10 % of the 2/2 genotype, 40 % of the 1/2 genotype, and 50 % of the 1/1 genotype. Taken together, our data indicate that the Jindo, Poongsan, and Sapsaree dogs harbor decreasing amounts of phenotypes responsible for inattention and impulsive behavior, in that order. Additionally, the Sapsaree genes harbor higher amounts of the 1/2 genotype than the Jindo and Poongsan genes, respectively. Korean dog breeds (dpeaa)DE-He213 Military working dogs (dpeaa)DE-He213 Polymorphism (dpeaa)DE-He213 Tyrosine hydroxylase (dpeaa)DE-He213 Variable number of tandem repeats (dpeaa)DE-He213 Choi, Bong-Hwan aut Lee, Dong-Hoon aut Kwon, Yun-Jeong aut Eo, Jungwoo aut Choi, Yuri aut Jeong, Hoim aut Gim, Jeong-An aut Kim, Tae-Hun aut Ha, Ji-Hong aut Han, Kook-Il aut Kim, Heui-Soo aut Enthalten in Genes & Genomics The Genetics Society of Korea, 2010 37(2014), 3 vom: 07. Nov., Seite 257-261 (DE-627)SPR031096425 nnns volume:37 year:2014 number:3 day:07 month:11 pages:257-261 https://dx.doi.org/10.1007/s13258-014-0243-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 37 2014 3 07 11 257-261 |
| spelling |
10.1007/s13258-014-0243-4 doi (DE-627)SPR031101887 (SPR)s13258-014-0243-4-e DE-627 ger DE-627 rakwb eng Lee, Hee-Eun verfasserin aut Polymorphism analysis of tyrosine hydroxylase gene variable number of tandem repeats in various Korean dogs 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Genetics Society of Korea and Springer-Science and Media 2014 Abstract Although humans and canines exhibit similar behavioral features, it is not easy to identify the corresponding behavioral phenotypes. The variable number of tandem repeats (VNTR) in intron 4 of the tyrosine hydroxylase (TH) gene is related to two characteristics, namely, impulsive activity and inattention. The TH genes are defined by three genotypes: type 1/1 comprises a single copy of TH VNTR; type 1/2 is heterozygote for both short allele and long allele; and type 2/2 is the doubled form of TH VNTR, which leads to inattention and impulsive actions. The 1/1 and 1/2 genotype have been identified as biomarkers for concentration and impulsive action. Therefore, we performed PCR amplification to detect the 1/2 genotypes in three canine breeds from Korea: Sapsaree (49), Poongsan (18), and Jindo (20). Our results indicate that the Sapsaree dog carries 27 % of the 2/2 genotype, 59 % of the 1/2 genotype, and 14 % of the 1/1 genotype; the Poongsan dog carries 11 % of the 2/2 genotype, 22 % of 1/2 genotype, and 67 % of 1/1 genotype; whereas the Jindo dog carries 10 % of the 2/2 genotype, 40 % of the 1/2 genotype, and 50 % of the 1/1 genotype. Taken together, our data indicate that the Jindo, Poongsan, and Sapsaree dogs harbor decreasing amounts of phenotypes responsible for inattention and impulsive behavior, in that order. Additionally, the Sapsaree genes harbor higher amounts of the 1/2 genotype than the Jindo and Poongsan genes, respectively. Korean dog breeds (dpeaa)DE-He213 Military working dogs (dpeaa)DE-He213 Polymorphism (dpeaa)DE-He213 Tyrosine hydroxylase (dpeaa)DE-He213 Variable number of tandem repeats (dpeaa)DE-He213 Choi, Bong-Hwan aut Lee, Dong-Hoon aut Kwon, Yun-Jeong aut Eo, Jungwoo aut Choi, Yuri aut Jeong, Hoim aut Gim, Jeong-An aut Kim, Tae-Hun aut Ha, Ji-Hong aut Han, Kook-Il aut Kim, Heui-Soo aut Enthalten in Genes & Genomics The Genetics Society of Korea, 2010 37(2014), 3 vom: 07. Nov., Seite 257-261 (DE-627)SPR031096425 nnns volume:37 year:2014 number:3 day:07 month:11 pages:257-261 https://dx.doi.org/10.1007/s13258-014-0243-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 37 2014 3 07 11 257-261 |
| allfields_unstemmed |
10.1007/s13258-014-0243-4 doi (DE-627)SPR031101887 (SPR)s13258-014-0243-4-e DE-627 ger DE-627 rakwb eng Lee, Hee-Eun verfasserin aut Polymorphism analysis of tyrosine hydroxylase gene variable number of tandem repeats in various Korean dogs 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Genetics Society of Korea and Springer-Science and Media 2014 Abstract Although humans and canines exhibit similar behavioral features, it is not easy to identify the corresponding behavioral phenotypes. The variable number of tandem repeats (VNTR) in intron 4 of the tyrosine hydroxylase (TH) gene is related to two characteristics, namely, impulsive activity and inattention. The TH genes are defined by three genotypes: type 1/1 comprises a single copy of TH VNTR; type 1/2 is heterozygote for both short allele and long allele; and type 2/2 is the doubled form of TH VNTR, which leads to inattention and impulsive actions. The 1/1 and 1/2 genotype have been identified as biomarkers for concentration and impulsive action. Therefore, we performed PCR amplification to detect the 1/2 genotypes in three canine breeds from Korea: Sapsaree (49), Poongsan (18), and Jindo (20). Our results indicate that the Sapsaree dog carries 27 % of the 2/2 genotype, 59 % of the 1/2 genotype, and 14 % of the 1/1 genotype; the Poongsan dog carries 11 % of the 2/2 genotype, 22 % of 1/2 genotype, and 67 % of 1/1 genotype; whereas the Jindo dog carries 10 % of the 2/2 genotype, 40 % of the 1/2 genotype, and 50 % of the 1/1 genotype. Taken together, our data indicate that the Jindo, Poongsan, and Sapsaree dogs harbor decreasing amounts of phenotypes responsible for inattention and impulsive behavior, in that order. Additionally, the Sapsaree genes harbor higher amounts of the 1/2 genotype than the Jindo and Poongsan genes, respectively. Korean dog breeds (dpeaa)DE-He213 Military working dogs (dpeaa)DE-He213 Polymorphism (dpeaa)DE-He213 Tyrosine hydroxylase (dpeaa)DE-He213 Variable number of tandem repeats (dpeaa)DE-He213 Choi, Bong-Hwan aut Lee, Dong-Hoon aut Kwon, Yun-Jeong aut Eo, Jungwoo aut Choi, Yuri aut Jeong, Hoim aut Gim, Jeong-An aut Kim, Tae-Hun aut Ha, Ji-Hong aut Han, Kook-Il aut Kim, Heui-Soo aut Enthalten in Genes & Genomics The Genetics Society of Korea, 2010 37(2014), 3 vom: 07. Nov., Seite 257-261 (DE-627)SPR031096425 nnns volume:37 year:2014 number:3 day:07 month:11 pages:257-261 https://dx.doi.org/10.1007/s13258-014-0243-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 37 2014 3 07 11 257-261 |
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10.1007/s13258-014-0243-4 doi (DE-627)SPR031101887 (SPR)s13258-014-0243-4-e DE-627 ger DE-627 rakwb eng Lee, Hee-Eun verfasserin aut Polymorphism analysis of tyrosine hydroxylase gene variable number of tandem repeats in various Korean dogs 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Genetics Society of Korea and Springer-Science and Media 2014 Abstract Although humans and canines exhibit similar behavioral features, it is not easy to identify the corresponding behavioral phenotypes. The variable number of tandem repeats (VNTR) in intron 4 of the tyrosine hydroxylase (TH) gene is related to two characteristics, namely, impulsive activity and inattention. The TH genes are defined by three genotypes: type 1/1 comprises a single copy of TH VNTR; type 1/2 is heterozygote for both short allele and long allele; and type 2/2 is the doubled form of TH VNTR, which leads to inattention and impulsive actions. The 1/1 and 1/2 genotype have been identified as biomarkers for concentration and impulsive action. Therefore, we performed PCR amplification to detect the 1/2 genotypes in three canine breeds from Korea: Sapsaree (49), Poongsan (18), and Jindo (20). Our results indicate that the Sapsaree dog carries 27 % of the 2/2 genotype, 59 % of the 1/2 genotype, and 14 % of the 1/1 genotype; the Poongsan dog carries 11 % of the 2/2 genotype, 22 % of 1/2 genotype, and 67 % of 1/1 genotype; whereas the Jindo dog carries 10 % of the 2/2 genotype, 40 % of the 1/2 genotype, and 50 % of the 1/1 genotype. Taken together, our data indicate that the Jindo, Poongsan, and Sapsaree dogs harbor decreasing amounts of phenotypes responsible for inattention and impulsive behavior, in that order. Additionally, the Sapsaree genes harbor higher amounts of the 1/2 genotype than the Jindo and Poongsan genes, respectively. Korean dog breeds (dpeaa)DE-He213 Military working dogs (dpeaa)DE-He213 Polymorphism (dpeaa)DE-He213 Tyrosine hydroxylase (dpeaa)DE-He213 Variable number of tandem repeats (dpeaa)DE-He213 Choi, Bong-Hwan aut Lee, Dong-Hoon aut Kwon, Yun-Jeong aut Eo, Jungwoo aut Choi, Yuri aut Jeong, Hoim aut Gim, Jeong-An aut Kim, Tae-Hun aut Ha, Ji-Hong aut Han, Kook-Il aut Kim, Heui-Soo aut Enthalten in Genes & Genomics The Genetics Society of Korea, 2010 37(2014), 3 vom: 07. Nov., Seite 257-261 (DE-627)SPR031096425 nnns volume:37 year:2014 number:3 day:07 month:11 pages:257-261 https://dx.doi.org/10.1007/s13258-014-0243-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 37 2014 3 07 11 257-261 |
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10.1007/s13258-014-0243-4 doi (DE-627)SPR031101887 (SPR)s13258-014-0243-4-e DE-627 ger DE-627 rakwb eng Lee, Hee-Eun verfasserin aut Polymorphism analysis of tyrosine hydroxylase gene variable number of tandem repeats in various Korean dogs 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Genetics Society of Korea and Springer-Science and Media 2014 Abstract Although humans and canines exhibit similar behavioral features, it is not easy to identify the corresponding behavioral phenotypes. The variable number of tandem repeats (VNTR) in intron 4 of the tyrosine hydroxylase (TH) gene is related to two characteristics, namely, impulsive activity and inattention. The TH genes are defined by three genotypes: type 1/1 comprises a single copy of TH VNTR; type 1/2 is heterozygote for both short allele and long allele; and type 2/2 is the doubled form of TH VNTR, which leads to inattention and impulsive actions. The 1/1 and 1/2 genotype have been identified as biomarkers for concentration and impulsive action. Therefore, we performed PCR amplification to detect the 1/2 genotypes in three canine breeds from Korea: Sapsaree (49), Poongsan (18), and Jindo (20). Our results indicate that the Sapsaree dog carries 27 % of the 2/2 genotype, 59 % of the 1/2 genotype, and 14 % of the 1/1 genotype; the Poongsan dog carries 11 % of the 2/2 genotype, 22 % of 1/2 genotype, and 67 % of 1/1 genotype; whereas the Jindo dog carries 10 % of the 2/2 genotype, 40 % of the 1/2 genotype, and 50 % of the 1/1 genotype. Taken together, our data indicate that the Jindo, Poongsan, and Sapsaree dogs harbor decreasing amounts of phenotypes responsible for inattention and impulsive behavior, in that order. Additionally, the Sapsaree genes harbor higher amounts of the 1/2 genotype than the Jindo and Poongsan genes, respectively. Korean dog breeds (dpeaa)DE-He213 Military working dogs (dpeaa)DE-He213 Polymorphism (dpeaa)DE-He213 Tyrosine hydroxylase (dpeaa)DE-He213 Variable number of tandem repeats (dpeaa)DE-He213 Choi, Bong-Hwan aut Lee, Dong-Hoon aut Kwon, Yun-Jeong aut Eo, Jungwoo aut Choi, Yuri aut Jeong, Hoim aut Gim, Jeong-An aut Kim, Tae-Hun aut Ha, Ji-Hong aut Han, Kook-Il aut Kim, Heui-Soo aut Enthalten in Genes & Genomics The Genetics Society of Korea, 2010 37(2014), 3 vom: 07. Nov., Seite 257-261 (DE-627)SPR031096425 nnns volume:37 year:2014 number:3 day:07 month:11 pages:257-261 https://dx.doi.org/10.1007/s13258-014-0243-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 37 2014 3 07 11 257-261 |
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Polymorphism analysis of tyrosine hydroxylase gene variable number of tandem repeats in various Korean dogs Korean dog breeds (dpeaa)DE-He213 Military working dogs (dpeaa)DE-He213 Polymorphism (dpeaa)DE-He213 Tyrosine hydroxylase (dpeaa)DE-He213 Variable number of tandem repeats (dpeaa)DE-He213 |
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Lee, Hee-Eun Choi, Bong-Hwan Lee, Dong-Hoon Kwon, Yun-Jeong Eo, Jungwoo Choi, Yuri Jeong, Hoim Gim, Jeong-An Kim, Tae-Hun Ha, Ji-Hong Han, Kook-Il Kim, Heui-Soo |
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polymorphism analysis of tyrosine hydroxylase gene variable number of tandem repeats in various korean dogs |
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Polymorphism analysis of tyrosine hydroxylase gene variable number of tandem repeats in various Korean dogs |
| abstract |
Abstract Although humans and canines exhibit similar behavioral features, it is not easy to identify the corresponding behavioral phenotypes. The variable number of tandem repeats (VNTR) in intron 4 of the tyrosine hydroxylase (TH) gene is related to two characteristics, namely, impulsive activity and inattention. The TH genes are defined by three genotypes: type 1/1 comprises a single copy of TH VNTR; type 1/2 is heterozygote for both short allele and long allele; and type 2/2 is the doubled form of TH VNTR, which leads to inattention and impulsive actions. The 1/1 and 1/2 genotype have been identified as biomarkers for concentration and impulsive action. Therefore, we performed PCR amplification to detect the 1/2 genotypes in three canine breeds from Korea: Sapsaree (49), Poongsan (18), and Jindo (20). Our results indicate that the Sapsaree dog carries 27 % of the 2/2 genotype, 59 % of the 1/2 genotype, and 14 % of the 1/1 genotype; the Poongsan dog carries 11 % of the 2/2 genotype, 22 % of 1/2 genotype, and 67 % of 1/1 genotype; whereas the Jindo dog carries 10 % of the 2/2 genotype, 40 % of the 1/2 genotype, and 50 % of the 1/1 genotype. Taken together, our data indicate that the Jindo, Poongsan, and Sapsaree dogs harbor decreasing amounts of phenotypes responsible for inattention and impulsive behavior, in that order. Additionally, the Sapsaree genes harbor higher amounts of the 1/2 genotype than the Jindo and Poongsan genes, respectively. © The Genetics Society of Korea and Springer-Science and Media 2014 |
| abstractGer |
Abstract Although humans and canines exhibit similar behavioral features, it is not easy to identify the corresponding behavioral phenotypes. The variable number of tandem repeats (VNTR) in intron 4 of the tyrosine hydroxylase (TH) gene is related to two characteristics, namely, impulsive activity and inattention. The TH genes are defined by three genotypes: type 1/1 comprises a single copy of TH VNTR; type 1/2 is heterozygote for both short allele and long allele; and type 2/2 is the doubled form of TH VNTR, which leads to inattention and impulsive actions. The 1/1 and 1/2 genotype have been identified as biomarkers for concentration and impulsive action. Therefore, we performed PCR amplification to detect the 1/2 genotypes in three canine breeds from Korea: Sapsaree (49), Poongsan (18), and Jindo (20). Our results indicate that the Sapsaree dog carries 27 % of the 2/2 genotype, 59 % of the 1/2 genotype, and 14 % of the 1/1 genotype; the Poongsan dog carries 11 % of the 2/2 genotype, 22 % of 1/2 genotype, and 67 % of 1/1 genotype; whereas the Jindo dog carries 10 % of the 2/2 genotype, 40 % of the 1/2 genotype, and 50 % of the 1/1 genotype. Taken together, our data indicate that the Jindo, Poongsan, and Sapsaree dogs harbor decreasing amounts of phenotypes responsible for inattention and impulsive behavior, in that order. Additionally, the Sapsaree genes harbor higher amounts of the 1/2 genotype than the Jindo and Poongsan genes, respectively. © The Genetics Society of Korea and Springer-Science and Media 2014 |
| abstract_unstemmed |
Abstract Although humans and canines exhibit similar behavioral features, it is not easy to identify the corresponding behavioral phenotypes. The variable number of tandem repeats (VNTR) in intron 4 of the tyrosine hydroxylase (TH) gene is related to two characteristics, namely, impulsive activity and inattention. The TH genes are defined by three genotypes: type 1/1 comprises a single copy of TH VNTR; type 1/2 is heterozygote for both short allele and long allele; and type 2/2 is the doubled form of TH VNTR, which leads to inattention and impulsive actions. The 1/1 and 1/2 genotype have been identified as biomarkers for concentration and impulsive action. Therefore, we performed PCR amplification to detect the 1/2 genotypes in three canine breeds from Korea: Sapsaree (49), Poongsan (18), and Jindo (20). Our results indicate that the Sapsaree dog carries 27 % of the 2/2 genotype, 59 % of the 1/2 genotype, and 14 % of the 1/1 genotype; the Poongsan dog carries 11 % of the 2/2 genotype, 22 % of 1/2 genotype, and 67 % of 1/1 genotype; whereas the Jindo dog carries 10 % of the 2/2 genotype, 40 % of the 1/2 genotype, and 50 % of the 1/1 genotype. Taken together, our data indicate that the Jindo, Poongsan, and Sapsaree dogs harbor decreasing amounts of phenotypes responsible for inattention and impulsive behavior, in that order. Additionally, the Sapsaree genes harbor higher amounts of the 1/2 genotype than the Jindo and Poongsan genes, respectively. © The Genetics Society of Korea and Springer-Science and Media 2014 |
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Polymorphism analysis of tyrosine hydroxylase gene variable number of tandem repeats in various Korean dogs |
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Choi, Bong-Hwan Lee, Dong-Hoon Kwon, Yun-Jeong Eo, Jungwoo Choi, Yuri Jeong, Hoim Gim, Jeong-An Kim, Tae-Hun Ha, Ji-Hong Han, Kook-Il Kim, Heui-Soo |
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