Chronological lifespan regulation of Saccharomyces cerevisiae by leucine biosynthesis pathway genes via TOR1 and COX2 expression regulation
Backgrounds Leucine is involved in various cellular mechanisms, including protein metabolism, insulin signaling, and longevity control. Nevertheless, the contribution of leucine metabolism genes to longevity have not been thoroughly studied. Methods Several mutants of leucine biosynthesis genes were...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Gorospe, Choco Michael [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2018 |
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| Schlagwörter: |
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| Anmerkung: |
© The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Nature B.V. 2019 |
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| Übergeordnetes Werk: |
Enthalten in: Molecular & cellular toxicology - Seoul : Korean Society of Toxicogenomics and Toxicoproteomics, 2005, 15(2018), 1 vom: 28. Dez., Seite 65-73 |
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| Übergeordnetes Werk: |
volume:15 ; year:2018 ; number:1 ; day:28 ; month:12 ; pages:65-73 |
| Links: |
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| DOI / URN: |
10.1007/s13273-019-0008-x |
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| Katalog-ID: |
SPR031119824 |
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| 024 | 7 | |a 10.1007/s13273-019-0008-x |2 doi | |
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| 041 | |a eng | ||
| 100 | 1 | |a Gorospe, Choco Michael |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Chronological lifespan regulation of Saccharomyces cerevisiae by leucine biosynthesis pathway genes via TOR1 and COX2 expression regulation |
| 264 | 1 | |c 2018 | |
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| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a © The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Nature B.V. 2019 | ||
| 520 | |a Backgrounds Leucine is involved in various cellular mechanisms, including protein metabolism, insulin signaling, and longevity control. Nevertheless, the contribution of leucine metabolism genes to longevity have not been thoroughly studied. Methods Several mutants of leucine biosynthesis genes were constructed, and their effect on yeast lifespan and various phenotypes were examined. Results Several deletion mutants increase yeast lifespan. Among those, LEU2 and leu4Δ cells exhibit significantly increased lifespan, moderately increased reactive oxygen species (ROS) generation, decreased Tor1p expression, significantly increased expression of a cytochrome c oxidase subunit, and decreased cell death. In these cells, reduced Tor1p seemed to stimulate a slight increase in ROS generation which stimulates Cox2p expression that can prevent cellular damage. Indeed, the rate of cell death of LEU2 and leu4Δ cells was drastically decreased. Conclusion LEU2 and LEU4 seem critical in determining yeast lifespan by providing a hormetic effect that promotes yeast longevity. | ||
| 650 | 4 | |a Yeast |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Leucine |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Chronological lifespan |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Yu, Sung-Lim |4 aut | |
| 700 | 1 | |a Kang, Mi-Sun |4 aut | |
| 700 | 1 | |a Lee, Sung-Keun |4 aut | |
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10.1007/s13273-019-0008-x doi (DE-627)SPR031119824 (SPR)s13273-019-0008-x-e DE-627 ger DE-627 rakwb eng Gorospe, Choco Michael verfasserin aut Chronological lifespan regulation of Saccharomyces cerevisiae by leucine biosynthesis pathway genes via TOR1 and COX2 expression regulation 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Nature B.V. 2019 Backgrounds Leucine is involved in various cellular mechanisms, including protein metabolism, insulin signaling, and longevity control. Nevertheless, the contribution of leucine metabolism genes to longevity have not been thoroughly studied. Methods Several mutants of leucine biosynthesis genes were constructed, and their effect on yeast lifespan and various phenotypes were examined. Results Several deletion mutants increase yeast lifespan. Among those, LEU2 and leu4Δ cells exhibit significantly increased lifespan, moderately increased reactive oxygen species (ROS) generation, decreased Tor1p expression, significantly increased expression of a cytochrome c oxidase subunit, and decreased cell death. In these cells, reduced Tor1p seemed to stimulate a slight increase in ROS generation which stimulates Cox2p expression that can prevent cellular damage. Indeed, the rate of cell death of LEU2 and leu4Δ cells was drastically decreased. Conclusion LEU2 and LEU4 seem critical in determining yeast lifespan by providing a hormetic effect that promotes yeast longevity. Yeast (dpeaa)DE-He213 Leucine (dpeaa)DE-He213 Chronological lifespan (dpeaa)DE-He213 Yu, Sung-Lim aut Kang, Mi-Sun aut Lee, Sung-Keun aut Enthalten in Molecular & cellular toxicology Seoul : Korean Society of Toxicogenomics and Toxicoproteomics, 2005 15(2018), 1 vom: 28. Dez., Seite 65-73 (DE-627)601532899 (DE-600)2498324-X 2092-8467 nnns volume:15 year:2018 number:1 day:28 month:12 pages:65-73 https://dx.doi.org/10.1007/s13273-019-0008-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 15 2018 1 28 12 65-73 |
| spelling |
10.1007/s13273-019-0008-x doi (DE-627)SPR031119824 (SPR)s13273-019-0008-x-e DE-627 ger DE-627 rakwb eng Gorospe, Choco Michael verfasserin aut Chronological lifespan regulation of Saccharomyces cerevisiae by leucine biosynthesis pathway genes via TOR1 and COX2 expression regulation 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Nature B.V. 2019 Backgrounds Leucine is involved in various cellular mechanisms, including protein metabolism, insulin signaling, and longevity control. Nevertheless, the contribution of leucine metabolism genes to longevity have not been thoroughly studied. Methods Several mutants of leucine biosynthesis genes were constructed, and their effect on yeast lifespan and various phenotypes were examined. Results Several deletion mutants increase yeast lifespan. Among those, LEU2 and leu4Δ cells exhibit significantly increased lifespan, moderately increased reactive oxygen species (ROS) generation, decreased Tor1p expression, significantly increased expression of a cytochrome c oxidase subunit, and decreased cell death. In these cells, reduced Tor1p seemed to stimulate a slight increase in ROS generation which stimulates Cox2p expression that can prevent cellular damage. Indeed, the rate of cell death of LEU2 and leu4Δ cells was drastically decreased. Conclusion LEU2 and LEU4 seem critical in determining yeast lifespan by providing a hormetic effect that promotes yeast longevity. Yeast (dpeaa)DE-He213 Leucine (dpeaa)DE-He213 Chronological lifespan (dpeaa)DE-He213 Yu, Sung-Lim aut Kang, Mi-Sun aut Lee, Sung-Keun aut Enthalten in Molecular & cellular toxicology Seoul : Korean Society of Toxicogenomics and Toxicoproteomics, 2005 15(2018), 1 vom: 28. Dez., Seite 65-73 (DE-627)601532899 (DE-600)2498324-X 2092-8467 nnns volume:15 year:2018 number:1 day:28 month:12 pages:65-73 https://dx.doi.org/10.1007/s13273-019-0008-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 15 2018 1 28 12 65-73 |
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10.1007/s13273-019-0008-x doi (DE-627)SPR031119824 (SPR)s13273-019-0008-x-e DE-627 ger DE-627 rakwb eng Gorospe, Choco Michael verfasserin aut Chronological lifespan regulation of Saccharomyces cerevisiae by leucine biosynthesis pathway genes via TOR1 and COX2 expression regulation 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Nature B.V. 2019 Backgrounds Leucine is involved in various cellular mechanisms, including protein metabolism, insulin signaling, and longevity control. Nevertheless, the contribution of leucine metabolism genes to longevity have not been thoroughly studied. Methods Several mutants of leucine biosynthesis genes were constructed, and their effect on yeast lifespan and various phenotypes were examined. Results Several deletion mutants increase yeast lifespan. Among those, LEU2 and leu4Δ cells exhibit significantly increased lifespan, moderately increased reactive oxygen species (ROS) generation, decreased Tor1p expression, significantly increased expression of a cytochrome c oxidase subunit, and decreased cell death. In these cells, reduced Tor1p seemed to stimulate a slight increase in ROS generation which stimulates Cox2p expression that can prevent cellular damage. Indeed, the rate of cell death of LEU2 and leu4Δ cells was drastically decreased. Conclusion LEU2 and LEU4 seem critical in determining yeast lifespan by providing a hormetic effect that promotes yeast longevity. Yeast (dpeaa)DE-He213 Leucine (dpeaa)DE-He213 Chronological lifespan (dpeaa)DE-He213 Yu, Sung-Lim aut Kang, Mi-Sun aut Lee, Sung-Keun aut Enthalten in Molecular & cellular toxicology Seoul : Korean Society of Toxicogenomics and Toxicoproteomics, 2005 15(2018), 1 vom: 28. Dez., Seite 65-73 (DE-627)601532899 (DE-600)2498324-X 2092-8467 nnns volume:15 year:2018 number:1 day:28 month:12 pages:65-73 https://dx.doi.org/10.1007/s13273-019-0008-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 15 2018 1 28 12 65-73 |
| allfieldsGer |
10.1007/s13273-019-0008-x doi (DE-627)SPR031119824 (SPR)s13273-019-0008-x-e DE-627 ger DE-627 rakwb eng Gorospe, Choco Michael verfasserin aut Chronological lifespan regulation of Saccharomyces cerevisiae by leucine biosynthesis pathway genes via TOR1 and COX2 expression regulation 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Nature B.V. 2019 Backgrounds Leucine is involved in various cellular mechanisms, including protein metabolism, insulin signaling, and longevity control. Nevertheless, the contribution of leucine metabolism genes to longevity have not been thoroughly studied. Methods Several mutants of leucine biosynthesis genes were constructed, and their effect on yeast lifespan and various phenotypes were examined. Results Several deletion mutants increase yeast lifespan. Among those, LEU2 and leu4Δ cells exhibit significantly increased lifespan, moderately increased reactive oxygen species (ROS) generation, decreased Tor1p expression, significantly increased expression of a cytochrome c oxidase subunit, and decreased cell death. In these cells, reduced Tor1p seemed to stimulate a slight increase in ROS generation which stimulates Cox2p expression that can prevent cellular damage. Indeed, the rate of cell death of LEU2 and leu4Δ cells was drastically decreased. Conclusion LEU2 and LEU4 seem critical in determining yeast lifespan by providing a hormetic effect that promotes yeast longevity. Yeast (dpeaa)DE-He213 Leucine (dpeaa)DE-He213 Chronological lifespan (dpeaa)DE-He213 Yu, Sung-Lim aut Kang, Mi-Sun aut Lee, Sung-Keun aut Enthalten in Molecular & cellular toxicology Seoul : Korean Society of Toxicogenomics and Toxicoproteomics, 2005 15(2018), 1 vom: 28. Dez., Seite 65-73 (DE-627)601532899 (DE-600)2498324-X 2092-8467 nnns volume:15 year:2018 number:1 day:28 month:12 pages:65-73 https://dx.doi.org/10.1007/s13273-019-0008-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 15 2018 1 28 12 65-73 |
| allfieldsSound |
10.1007/s13273-019-0008-x doi (DE-627)SPR031119824 (SPR)s13273-019-0008-x-e DE-627 ger DE-627 rakwb eng Gorospe, Choco Michael verfasserin aut Chronological lifespan regulation of Saccharomyces cerevisiae by leucine biosynthesis pathway genes via TOR1 and COX2 expression regulation 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Nature B.V. 2019 Backgrounds Leucine is involved in various cellular mechanisms, including protein metabolism, insulin signaling, and longevity control. Nevertheless, the contribution of leucine metabolism genes to longevity have not been thoroughly studied. Methods Several mutants of leucine biosynthesis genes were constructed, and their effect on yeast lifespan and various phenotypes were examined. Results Several deletion mutants increase yeast lifespan. Among those, LEU2 and leu4Δ cells exhibit significantly increased lifespan, moderately increased reactive oxygen species (ROS) generation, decreased Tor1p expression, significantly increased expression of a cytochrome c oxidase subunit, and decreased cell death. In these cells, reduced Tor1p seemed to stimulate a slight increase in ROS generation which stimulates Cox2p expression that can prevent cellular damage. Indeed, the rate of cell death of LEU2 and leu4Δ cells was drastically decreased. Conclusion LEU2 and LEU4 seem critical in determining yeast lifespan by providing a hormetic effect that promotes yeast longevity. Yeast (dpeaa)DE-He213 Leucine (dpeaa)DE-He213 Chronological lifespan (dpeaa)DE-He213 Yu, Sung-Lim aut Kang, Mi-Sun aut Lee, Sung-Keun aut Enthalten in Molecular & cellular toxicology Seoul : Korean Society of Toxicogenomics and Toxicoproteomics, 2005 15(2018), 1 vom: 28. Dez., Seite 65-73 (DE-627)601532899 (DE-600)2498324-X 2092-8467 nnns volume:15 year:2018 number:1 day:28 month:12 pages:65-73 https://dx.doi.org/10.1007/s13273-019-0008-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 15 2018 1 28 12 65-73 |
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Enthalten in Molecular & cellular toxicology 15(2018), 1 vom: 28. Dez., Seite 65-73 volume:15 year:2018 number:1 day:28 month:12 pages:65-73 |
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Enthalten in Molecular & cellular toxicology 15(2018), 1 vom: 28. Dez., Seite 65-73 volume:15 year:2018 number:1 day:28 month:12 pages:65-73 |
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Gorospe, Choco Michael @@aut@@ Yu, Sung-Lim @@aut@@ Kang, Mi-Sun @@aut@@ Lee, Sung-Keun @@aut@@ |
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2018-12-28T00:00:00Z |
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Nevertheless, the contribution of leucine metabolism genes to longevity have not been thoroughly studied. Methods Several mutants of leucine biosynthesis genes were constructed, and their effect on yeast lifespan and various phenotypes were examined. Results Several deletion mutants increase yeast lifespan. Among those, LEU2 and leu4Δ cells exhibit significantly increased lifespan, moderately increased reactive oxygen species (ROS) generation, decreased Tor1p expression, significantly increased expression of a cytochrome c oxidase subunit, and decreased cell death. In these cells, reduced Tor1p seemed to stimulate a slight increase in ROS generation which stimulates Cox2p expression that can prevent cellular damage. Indeed, the rate of cell death of LEU2 and leu4Δ cells was drastically decreased. 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Gorospe, Choco Michael |
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Gorospe, Choco Michael misc Yeast misc Leucine misc Chronological lifespan Chronological lifespan regulation of Saccharomyces cerevisiae by leucine biosynthesis pathway genes via TOR1 and COX2 expression regulation |
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Chronological lifespan regulation of Saccharomyces cerevisiae by leucine biosynthesis pathway genes via TOR1 and COX2 expression regulation Yeast (dpeaa)DE-He213 Leucine (dpeaa)DE-He213 Chronological lifespan (dpeaa)DE-He213 |
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Chronological lifespan regulation of Saccharomyces cerevisiae by leucine biosynthesis pathway genes via TOR1 and COX2 expression regulation |
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Chronological lifespan regulation of Saccharomyces cerevisiae by leucine biosynthesis pathway genes via TOR1 and COX2 expression regulation |
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Gorospe, Choco Michael |
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Molecular & cellular toxicology |
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Gorospe, Choco Michael Yu, Sung-Lim Kang, Mi-Sun Lee, Sung-Keun |
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Gorospe, Choco Michael |
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chronological lifespan regulation of saccharomyces cerevisiae by leucine biosynthesis pathway genes via tor1 and cox2 expression regulation |
| title_auth |
Chronological lifespan regulation of Saccharomyces cerevisiae by leucine biosynthesis pathway genes via TOR1 and COX2 expression regulation |
| abstract |
Backgrounds Leucine is involved in various cellular mechanisms, including protein metabolism, insulin signaling, and longevity control. Nevertheless, the contribution of leucine metabolism genes to longevity have not been thoroughly studied. Methods Several mutants of leucine biosynthesis genes were constructed, and their effect on yeast lifespan and various phenotypes were examined. Results Several deletion mutants increase yeast lifespan. Among those, LEU2 and leu4Δ cells exhibit significantly increased lifespan, moderately increased reactive oxygen species (ROS) generation, decreased Tor1p expression, significantly increased expression of a cytochrome c oxidase subunit, and decreased cell death. In these cells, reduced Tor1p seemed to stimulate a slight increase in ROS generation which stimulates Cox2p expression that can prevent cellular damage. Indeed, the rate of cell death of LEU2 and leu4Δ cells was drastically decreased. Conclusion LEU2 and LEU4 seem critical in determining yeast lifespan by providing a hormetic effect that promotes yeast longevity. © The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Nature B.V. 2019 |
| abstractGer |
Backgrounds Leucine is involved in various cellular mechanisms, including protein metabolism, insulin signaling, and longevity control. Nevertheless, the contribution of leucine metabolism genes to longevity have not been thoroughly studied. Methods Several mutants of leucine biosynthesis genes were constructed, and their effect on yeast lifespan and various phenotypes were examined. Results Several deletion mutants increase yeast lifespan. Among those, LEU2 and leu4Δ cells exhibit significantly increased lifespan, moderately increased reactive oxygen species (ROS) generation, decreased Tor1p expression, significantly increased expression of a cytochrome c oxidase subunit, and decreased cell death. In these cells, reduced Tor1p seemed to stimulate a slight increase in ROS generation which stimulates Cox2p expression that can prevent cellular damage. Indeed, the rate of cell death of LEU2 and leu4Δ cells was drastically decreased. Conclusion LEU2 and LEU4 seem critical in determining yeast lifespan by providing a hormetic effect that promotes yeast longevity. © The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Nature B.V. 2019 |
| abstract_unstemmed |
Backgrounds Leucine is involved in various cellular mechanisms, including protein metabolism, insulin signaling, and longevity control. Nevertheless, the contribution of leucine metabolism genes to longevity have not been thoroughly studied. Methods Several mutants of leucine biosynthesis genes were constructed, and their effect on yeast lifespan and various phenotypes were examined. Results Several deletion mutants increase yeast lifespan. Among those, LEU2 and leu4Δ cells exhibit significantly increased lifespan, moderately increased reactive oxygen species (ROS) generation, decreased Tor1p expression, significantly increased expression of a cytochrome c oxidase subunit, and decreased cell death. In these cells, reduced Tor1p seemed to stimulate a slight increase in ROS generation which stimulates Cox2p expression that can prevent cellular damage. Indeed, the rate of cell death of LEU2 and leu4Δ cells was drastically decreased. Conclusion LEU2 and LEU4 seem critical in determining yeast lifespan by providing a hormetic effect that promotes yeast longevity. © The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Nature B.V. 2019 |
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Chronological lifespan regulation of Saccharomyces cerevisiae by leucine biosynthesis pathway genes via TOR1 and COX2 expression regulation |
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https://dx.doi.org/10.1007/s13273-019-0008-x |
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Yu, Sung-Lim Kang, Mi-Sun Lee, Sung-Keun |
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Yu, Sung-Lim Kang, Mi-Sun Lee, Sung-Keun |
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10.1007/s13273-019-0008-x |
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2024-07-03T22:05:18.955Z |
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