Correlation between Rho-kinase pathway gene expressions and development and progression of glioblastoma multiforme

Abstract Glioblastoma multiforme (GBM) is the most common and the most aggressive primary malignant tumor of the brain. Prognostic factors in GBM can be sorted as age, tumor localization, tumor diameter, symptom period and type, the extent of surgery, postoperative tumor volume, and adjuvant radioth...
Ausführliche Beschreibung

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Autor*in:	Erkutlu, Ibrahim [verfasserIn] Cigiloglu, Ahmet Kalender, Mehmet Emin Alptekin, Mehmet Demiryurek, A. Tuncay Suner, Ali Ozkaya, Esma Ulaslı, Mustafa Camcı, Celalettin

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	Glioblastoma multiforme Rho-kinase LIM-kinase Cofilin

Anmerkung:	© International Society of Oncology and BioMarkers (ISOBM) 2013

Übergeordnetes Werk:	Enthalten in: Tumor biology - Amsterdam : IOS Press, 1987, 34(2013), 2 vom: 22. Jan., Seite 1139-1144
Übergeordnetes Werk:	volume:34 ; year:2013 ; number:2 ; day:22 ; month:01 ; pages:1139-1144

Links:	Volltext

DOI / URN:	10.1007/s13277-013-0655-9

Katalog-ID:	SPR031127800

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allfields	10.1007/s13277-013-0655-9 doi (DE-627)SPR031127800 (SPR)s13277-013-0655-9-e DE-627 ger DE-627 rakwb eng Erkutlu, Ibrahim verfasserin aut Correlation between Rho-kinase pathway gene expressions and development and progression of glioblastoma multiforme 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © International Society of Oncology and BioMarkers (ISOBM) 2013 Abstract Glioblastoma multiforme (GBM) is the most common and the most aggressive primary malignant tumor of the brain. Prognostic factors in GBM can be sorted as age, tumor localization, tumor diameter, symptom period and type, the extent of surgery, postoperative tumor volume, and adjuvant radiotherapy and/or chemotherapy status. Besides the interactions between actin microfilaments, microtubules, and intermediate filaments, environmental factors and intracellular signals which regulate them affect the cell invasion. Rho proteins and therefore Rho-kinase activation play important role at these changes. The aim of this study is to evaluate the relationship between the Rho-kinase pathway gene expressions and prognosis in GBM. Ninety-eight patients diagnosed as GBM between 2001 and 2010 were enrolled into the study. RNA was obtained from the paraffinized tumor tissue of the patients with formalin-fixed, paraffin-embedded RNA isolation kit and the mRNA expressions of 26 genes were investigated. There was a statistically significant negative correlation between the ages at the diagnosis and survival. There was a significant relationship between the overexpression of Rho-kinase pathway-related genes LIMK1, CFL1, CFL2, and BCL2 and low expression of MAPK1 gene and the survival of the patients. These results demonstrate for the first time that there is a marked contribution of Rho-kinase pathway-related genes to the progression and survival of the GBM. The expression of these genes may be related to response of multimodal therapy or these parameters could be used to determine possible unresponsive patients before treatment. Glioblastoma multiforme (dpeaa)DE-He213 Rho-kinase (dpeaa)DE-He213 LIM-kinase (dpeaa)DE-He213 Cofilin (dpeaa)DE-He213 Cigiloglu, Ahmet aut Kalender, Mehmet Emin aut Alptekin, Mehmet aut Demiryurek, A. Tuncay aut Suner, Ali aut Ozkaya, Esma aut Ulaslı, Mustafa aut Camcı, Celalettin aut Enthalten in Tumor biology Amsterdam : IOS Press, 1987 34(2013), 2 vom: 22. Jan., Seite 1139-1144 (DE-627)300897855 (DE-600)1483579-4 1423-0380 nnns volume:34 year:2013 number:2 day:22 month:01 pages:1139-1144 https://dx.doi.org/10.1007/s13277-013-0655-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_22 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_63 GBV_ILN_95 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_370 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4338 AR 34 2013 2 22 01 1139-1144
spelling	10.1007/s13277-013-0655-9 doi (DE-627)SPR031127800 (SPR)s13277-013-0655-9-e DE-627 ger DE-627 rakwb eng Erkutlu, Ibrahim verfasserin aut Correlation between Rho-kinase pathway gene expressions and development and progression of glioblastoma multiforme 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © International Society of Oncology and BioMarkers (ISOBM) 2013 Abstract Glioblastoma multiforme (GBM) is the most common and the most aggressive primary malignant tumor of the brain. Prognostic factors in GBM can be sorted as age, tumor localization, tumor diameter, symptom period and type, the extent of surgery, postoperative tumor volume, and adjuvant radiotherapy and/or chemotherapy status. Besides the interactions between actin microfilaments, microtubules, and intermediate filaments, environmental factors and intracellular signals which regulate them affect the cell invasion. Rho proteins and therefore Rho-kinase activation play important role at these changes. The aim of this study is to evaluate the relationship between the Rho-kinase pathway gene expressions and prognosis in GBM. Ninety-eight patients diagnosed as GBM between 2001 and 2010 were enrolled into the study. RNA was obtained from the paraffinized tumor tissue of the patients with formalin-fixed, paraffin-embedded RNA isolation kit and the mRNA expressions of 26 genes were investigated. There was a statistically significant negative correlation between the ages at the diagnosis and survival. There was a significant relationship between the overexpression of Rho-kinase pathway-related genes LIMK1, CFL1, CFL2, and BCL2 and low expression of MAPK1 gene and the survival of the patients. These results demonstrate for the first time that there is a marked contribution of Rho-kinase pathway-related genes to the progression and survival of the GBM. The expression of these genes may be related to response of multimodal therapy or these parameters could be used to determine possible unresponsive patients before treatment. Glioblastoma multiforme (dpeaa)DE-He213 Rho-kinase (dpeaa)DE-He213 LIM-kinase (dpeaa)DE-He213 Cofilin (dpeaa)DE-He213 Cigiloglu, Ahmet aut Kalender, Mehmet Emin aut Alptekin, Mehmet aut Demiryurek, A. Tuncay aut Suner, Ali aut Ozkaya, Esma aut Ulaslı, Mustafa aut Camcı, Celalettin aut Enthalten in Tumor biology Amsterdam : IOS Press, 1987 34(2013), 2 vom: 22. Jan., Seite 1139-1144 (DE-627)300897855 (DE-600)1483579-4 1423-0380 nnns volume:34 year:2013 number:2 day:22 month:01 pages:1139-1144 https://dx.doi.org/10.1007/s13277-013-0655-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_22 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_63 GBV_ILN_95 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_370 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4338 AR 34 2013 2 22 01 1139-1144
allfields_unstemmed	10.1007/s13277-013-0655-9 doi (DE-627)SPR031127800 (SPR)s13277-013-0655-9-e DE-627 ger DE-627 rakwb eng Erkutlu, Ibrahim verfasserin aut Correlation between Rho-kinase pathway gene expressions and development and progression of glioblastoma multiforme 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © International Society of Oncology and BioMarkers (ISOBM) 2013 Abstract Glioblastoma multiforme (GBM) is the most common and the most aggressive primary malignant tumor of the brain. Prognostic factors in GBM can be sorted as age, tumor localization, tumor diameter, symptom period and type, the extent of surgery, postoperative tumor volume, and adjuvant radiotherapy and/or chemotherapy status. Besides the interactions between actin microfilaments, microtubules, and intermediate filaments, environmental factors and intracellular signals which regulate them affect the cell invasion. Rho proteins and therefore Rho-kinase activation play important role at these changes. The aim of this study is to evaluate the relationship between the Rho-kinase pathway gene expressions and prognosis in GBM. Ninety-eight patients diagnosed as GBM between 2001 and 2010 were enrolled into the study. RNA was obtained from the paraffinized tumor tissue of the patients with formalin-fixed, paraffin-embedded RNA isolation kit and the mRNA expressions of 26 genes were investigated. There was a statistically significant negative correlation between the ages at the diagnosis and survival. There was a significant relationship between the overexpression of Rho-kinase pathway-related genes LIMK1, CFL1, CFL2, and BCL2 and low expression of MAPK1 gene and the survival of the patients. These results demonstrate for the first time that there is a marked contribution of Rho-kinase pathway-related genes to the progression and survival of the GBM. The expression of these genes may be related to response of multimodal therapy or these parameters could be used to determine possible unresponsive patients before treatment. Glioblastoma multiforme (dpeaa)DE-He213 Rho-kinase (dpeaa)DE-He213 LIM-kinase (dpeaa)DE-He213 Cofilin (dpeaa)DE-He213 Cigiloglu, Ahmet aut Kalender, Mehmet Emin aut Alptekin, Mehmet aut Demiryurek, A. Tuncay aut Suner, Ali aut Ozkaya, Esma aut Ulaslı, Mustafa aut Camcı, Celalettin aut Enthalten in Tumor biology Amsterdam : IOS Press, 1987 34(2013), 2 vom: 22. Jan., Seite 1139-1144 (DE-627)300897855 (DE-600)1483579-4 1423-0380 nnns volume:34 year:2013 number:2 day:22 month:01 pages:1139-1144 https://dx.doi.org/10.1007/s13277-013-0655-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_22 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_63 GBV_ILN_95 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_370 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4338 AR 34 2013 2 22 01 1139-1144
allfieldsGer	10.1007/s13277-013-0655-9 doi (DE-627)SPR031127800 (SPR)s13277-013-0655-9-e DE-627 ger DE-627 rakwb eng Erkutlu, Ibrahim verfasserin aut Correlation between Rho-kinase pathway gene expressions and development and progression of glioblastoma multiforme 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © International Society of Oncology and BioMarkers (ISOBM) 2013 Abstract Glioblastoma multiforme (GBM) is the most common and the most aggressive primary malignant tumor of the brain. Prognostic factors in GBM can be sorted as age, tumor localization, tumor diameter, symptom period and type, the extent of surgery, postoperative tumor volume, and adjuvant radiotherapy and/or chemotherapy status. Besides the interactions between actin microfilaments, microtubules, and intermediate filaments, environmental factors and intracellular signals which regulate them affect the cell invasion. Rho proteins and therefore Rho-kinase activation play important role at these changes. The aim of this study is to evaluate the relationship between the Rho-kinase pathway gene expressions and prognosis in GBM. Ninety-eight patients diagnosed as GBM between 2001 and 2010 were enrolled into the study. RNA was obtained from the paraffinized tumor tissue of the patients with formalin-fixed, paraffin-embedded RNA isolation kit and the mRNA expressions of 26 genes were investigated. There was a statistically significant negative correlation between the ages at the diagnosis and survival. There was a significant relationship between the overexpression of Rho-kinase pathway-related genes LIMK1, CFL1, CFL2, and BCL2 and low expression of MAPK1 gene and the survival of the patients. These results demonstrate for the first time that there is a marked contribution of Rho-kinase pathway-related genes to the progression and survival of the GBM. The expression of these genes may be related to response of multimodal therapy or these parameters could be used to determine possible unresponsive patients before treatment. Glioblastoma multiforme (dpeaa)DE-He213 Rho-kinase (dpeaa)DE-He213 LIM-kinase (dpeaa)DE-He213 Cofilin (dpeaa)DE-He213 Cigiloglu, Ahmet aut Kalender, Mehmet Emin aut Alptekin, Mehmet aut Demiryurek, A. Tuncay aut Suner, Ali aut Ozkaya, Esma aut Ulaslı, Mustafa aut Camcı, Celalettin aut Enthalten in Tumor biology Amsterdam : IOS Press, 1987 34(2013), 2 vom: 22. Jan., Seite 1139-1144 (DE-627)300897855 (DE-600)1483579-4 1423-0380 nnns volume:34 year:2013 number:2 day:22 month:01 pages:1139-1144 https://dx.doi.org/10.1007/s13277-013-0655-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_22 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_63 GBV_ILN_95 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_370 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4338 AR 34 2013 2 22 01 1139-1144
allfieldsSound	10.1007/s13277-013-0655-9 doi (DE-627)SPR031127800 (SPR)s13277-013-0655-9-e DE-627 ger DE-627 rakwb eng Erkutlu, Ibrahim verfasserin aut Correlation between Rho-kinase pathway gene expressions and development and progression of glioblastoma multiforme 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © International Society of Oncology and BioMarkers (ISOBM) 2013 Abstract Glioblastoma multiforme (GBM) is the most common and the most aggressive primary malignant tumor of the brain. Prognostic factors in GBM can be sorted as age, tumor localization, tumor diameter, symptom period and type, the extent of surgery, postoperative tumor volume, and adjuvant radiotherapy and/or chemotherapy status. Besides the interactions between actin microfilaments, microtubules, and intermediate filaments, environmental factors and intracellular signals which regulate them affect the cell invasion. Rho proteins and therefore Rho-kinase activation play important role at these changes. The aim of this study is to evaluate the relationship between the Rho-kinase pathway gene expressions and prognosis in GBM. Ninety-eight patients diagnosed as GBM between 2001 and 2010 were enrolled into the study. RNA was obtained from the paraffinized tumor tissue of the patients with formalin-fixed, paraffin-embedded RNA isolation kit and the mRNA expressions of 26 genes were investigated. There was a statistically significant negative correlation between the ages at the diagnosis and survival. There was a significant relationship between the overexpression of Rho-kinase pathway-related genes LIMK1, CFL1, CFL2, and BCL2 and low expression of MAPK1 gene and the survival of the patients. These results demonstrate for the first time that there is a marked contribution of Rho-kinase pathway-related genes to the progression and survival of the GBM. The expression of these genes may be related to response of multimodal therapy or these parameters could be used to determine possible unresponsive patients before treatment. Glioblastoma multiforme (dpeaa)DE-He213 Rho-kinase (dpeaa)DE-He213 LIM-kinase (dpeaa)DE-He213 Cofilin (dpeaa)DE-He213 Cigiloglu, Ahmet aut Kalender, Mehmet Emin aut Alptekin, Mehmet aut Demiryurek, A. Tuncay aut Suner, Ali aut Ozkaya, Esma aut Ulaslı, Mustafa aut Camcı, Celalettin aut Enthalten in Tumor biology Amsterdam : IOS Press, 1987 34(2013), 2 vom: 22. Jan., Seite 1139-1144 (DE-627)300897855 (DE-600)1483579-4 1423-0380 nnns volume:34 year:2013 number:2 day:22 month:01 pages:1139-1144 https://dx.doi.org/10.1007/s13277-013-0655-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_22 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_63 GBV_ILN_95 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_370 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4338 AR 34 2013 2 22 01 1139-1144
language	English
source	Enthalten in Tumor biology 34(2013), 2 vom: 22. Jan., Seite 1139-1144 volume:34 year:2013 number:2 day:22 month:01 pages:1139-1144
sourceStr	Enthalten in Tumor biology 34(2013), 2 vom: 22. Jan., Seite 1139-1144 volume:34 year:2013 number:2 day:22 month:01 pages:1139-1144
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Glioblastoma multiforme Rho-kinase LIM-kinase Cofilin
isfreeaccess_bool	false
container_title	Tumor biology
authorswithroles_txt_mv	Erkutlu, Ibrahim @@aut@@ Cigiloglu, Ahmet @@aut@@ Kalender, Mehmet Emin @@aut@@ Alptekin, Mehmet @@aut@@ Demiryurek, A. Tuncay @@aut@@ Suner, Ali @@aut@@ Ozkaya, Esma @@aut@@ Ulaslı, Mustafa @@aut@@ Camcı, Celalettin @@aut@@
publishDateDaySort_date	2013-01-22T00:00:00Z
hierarchy_top_id	300897855
id	SPR031127800
language_de	englisch
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author	Erkutlu, Ibrahim
spellingShingle	Erkutlu, Ibrahim misc Glioblastoma multiforme misc Rho-kinase misc LIM-kinase misc Cofilin Correlation between Rho-kinase pathway gene expressions and development and progression of glioblastoma multiforme
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topic_title	Correlation between Rho-kinase pathway gene expressions and development and progression of glioblastoma multiforme Glioblastoma multiforme (dpeaa)DE-He213 Rho-kinase (dpeaa)DE-He213 LIM-kinase (dpeaa)DE-He213 Cofilin (dpeaa)DE-He213
topic	misc Glioblastoma multiforme misc Rho-kinase misc LIM-kinase misc Cofilin
topic_unstemmed	misc Glioblastoma multiforme misc Rho-kinase misc LIM-kinase misc Cofilin
topic_browse	misc Glioblastoma multiforme misc Rho-kinase misc LIM-kinase misc Cofilin
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title	Correlation between Rho-kinase pathway gene expressions and development and progression of glioblastoma multiforme
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title_full	Correlation between Rho-kinase pathway gene expressions and development and progression of glioblastoma multiforme
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author_browse	Erkutlu, Ibrahim Cigiloglu, Ahmet Kalender, Mehmet Emin Alptekin, Mehmet Demiryurek, A. Tuncay Suner, Ali Ozkaya, Esma Ulaslı, Mustafa Camcı, Celalettin
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doi_str_mv	10.1007/s13277-013-0655-9
title_sort	correlation between rho-kinase pathway gene expressions and development and progression of glioblastoma multiforme
title_auth	Correlation between Rho-kinase pathway gene expressions and development and progression of glioblastoma multiforme
abstract	Abstract Glioblastoma multiforme (GBM) is the most common and the most aggressive primary malignant tumor of the brain. Prognostic factors in GBM can be sorted as age, tumor localization, tumor diameter, symptom period and type, the extent of surgery, postoperative tumor volume, and adjuvant radiotherapy and/or chemotherapy status. Besides the interactions between actin microfilaments, microtubules, and intermediate filaments, environmental factors and intracellular signals which regulate them affect the cell invasion. Rho proteins and therefore Rho-kinase activation play important role at these changes. The aim of this study is to evaluate the relationship between the Rho-kinase pathway gene expressions and prognosis in GBM. Ninety-eight patients diagnosed as GBM between 2001 and 2010 were enrolled into the study. RNA was obtained from the paraffinized tumor tissue of the patients with formalin-fixed, paraffin-embedded RNA isolation kit and the mRNA expressions of 26 genes were investigated. There was a statistically significant negative correlation between the ages at the diagnosis and survival. There was a significant relationship between the overexpression of Rho-kinase pathway-related genes LIMK1, CFL1, CFL2, and BCL2 and low expression of MAPK1 gene and the survival of the patients. These results demonstrate for the first time that there is a marked contribution of Rho-kinase pathway-related genes to the progression and survival of the GBM. The expression of these genes may be related to response of multimodal therapy or these parameters could be used to determine possible unresponsive patients before treatment. © International Society of Oncology and BioMarkers (ISOBM) 2013
abstractGer	Abstract Glioblastoma multiforme (GBM) is the most common and the most aggressive primary malignant tumor of the brain. Prognostic factors in GBM can be sorted as age, tumor localization, tumor diameter, symptom period and type, the extent of surgery, postoperative tumor volume, and adjuvant radiotherapy and/or chemotherapy status. Besides the interactions between actin microfilaments, microtubules, and intermediate filaments, environmental factors and intracellular signals which regulate them affect the cell invasion. Rho proteins and therefore Rho-kinase activation play important role at these changes. The aim of this study is to evaluate the relationship between the Rho-kinase pathway gene expressions and prognosis in GBM. Ninety-eight patients diagnosed as GBM between 2001 and 2010 were enrolled into the study. RNA was obtained from the paraffinized tumor tissue of the patients with formalin-fixed, paraffin-embedded RNA isolation kit and the mRNA expressions of 26 genes were investigated. There was a statistically significant negative correlation between the ages at the diagnosis and survival. There was a significant relationship between the overexpression of Rho-kinase pathway-related genes LIMK1, CFL1, CFL2, and BCL2 and low expression of MAPK1 gene and the survival of the patients. These results demonstrate for the first time that there is a marked contribution of Rho-kinase pathway-related genes to the progression and survival of the GBM. The expression of these genes may be related to response of multimodal therapy or these parameters could be used to determine possible unresponsive patients before treatment. © International Society of Oncology and BioMarkers (ISOBM) 2013
abstract_unstemmed	Abstract Glioblastoma multiforme (GBM) is the most common and the most aggressive primary malignant tumor of the brain. Prognostic factors in GBM can be sorted as age, tumor localization, tumor diameter, symptom period and type, the extent of surgery, postoperative tumor volume, and adjuvant radiotherapy and/or chemotherapy status. Besides the interactions between actin microfilaments, microtubules, and intermediate filaments, environmental factors and intracellular signals which regulate them affect the cell invasion. Rho proteins and therefore Rho-kinase activation play important role at these changes. The aim of this study is to evaluate the relationship between the Rho-kinase pathway gene expressions and prognosis in GBM. Ninety-eight patients diagnosed as GBM between 2001 and 2010 were enrolled into the study. RNA was obtained from the paraffinized tumor tissue of the patients with formalin-fixed, paraffin-embedded RNA isolation kit and the mRNA expressions of 26 genes were investigated. There was a statistically significant negative correlation between the ages at the diagnosis and survival. There was a significant relationship between the overexpression of Rho-kinase pathway-related genes LIMK1, CFL1, CFL2, and BCL2 and low expression of MAPK1 gene and the survival of the patients. These results demonstrate for the first time that there is a marked contribution of Rho-kinase pathway-related genes to the progression and survival of the GBM. The expression of these genes may be related to response of multimodal therapy or these parameters could be used to determine possible unresponsive patients before treatment. © International Society of Oncology and BioMarkers (ISOBM) 2013
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title_short	Correlation between Rho-kinase pathway gene expressions and development and progression of glioblastoma multiforme
url	https://dx.doi.org/10.1007/s13277-013-0655-9
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Correlation between Rho-kinase pathway gene expressions and development and progression of glioblastoma multiforme

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