microRNAs in uterine sarcomas and mixed epithelial–mesenchymal uterine tumors: a preliminary report

Abstract Uterine sarcomas and mixed epithelial–mesenchymal uterine tumors are a heterogeneous group of rare tumors for which there are very few diagnostic markers available. As aberrant microRNA (miRNA) expression patterns represent putative diagnostic cancer markers, we aimed to identify miRNA expr...
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Autor*in:	Kowalewska, Magdalena [verfasserIn] Bakula-Zalewska, Elwira Chechlinska, Magdalena Goryca, Krzysztof Nasierowska-Guttmejer, Anna Danska-Bidzinska, Anna Bidzinski, Mariusz

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	Uterine sarcoma Carcinosarcoma Adenosarcoma Endometrial sarcoma Leiomyosarcoma microRNA Biomarkers

Anmerkung:	© The Author(s) 2013

Übergeordnetes Werk:	Enthalten in: Tumor biology - Amsterdam : IOS Press, 1987, 34(2013), 4 vom: 05. Apr., Seite 2153-2160
Übergeordnetes Werk:	volume:34 ; year:2013 ; number:4 ; day:05 ; month:04 ; pages:2153-2160

Links:	Volltext

DOI / URN:	10.1007/s13277-013-0748-5

Katalog-ID:	SPR031128920

Internformat


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allfields	10.1007/s13277-013-0748-5 doi (DE-627)SPR031128920 (SPR)s13277-013-0748-5-e DE-627 ger DE-627 rakwb eng Kowalewska, Magdalena verfasserin aut microRNAs in uterine sarcomas and mixed epithelial–mesenchymal uterine tumors: a preliminary report 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2013 Abstract Uterine sarcomas and mixed epithelial–mesenchymal uterine tumors are a heterogeneous group of rare tumors for which there are very few diagnostic markers available. As aberrant microRNA (miRNA) expression patterns represent putative diagnostic cancer markers, we aimed to identify miRNA expression profiles of the major uterine sarcoma subtypes and mixed epithelial–mesenchymal tumors of the uterus. Eighty-eight miRNAs were assessed by quantitative RT-PCR in cancerous and non-cancerous tissue samples collected from 29 patients with endometrial sarcoma, leiomyosarcoma, and mixed epithelial–mesenchymal tumors. Tumor and control samples significantly (P < 0.05) differed in the expression of miR-23b, miR-1, let-7f, and let-7c in endometrial sarcomas, and miR-1, let-7c, miR-133b, let-7b, miR-143, let-7a, let-7d, let-7e, let-7g, miR-222, let-7i, and miR-214 in mixed epithelial–mesenchymal tumors. All the significantly changed miRNAs were down-regulated in the malignant tissues as compared to their normal counterparts. This may suggest their tumor suppressor role in these malignancies. No statistically significant changes in miRNA expression levels were found between leiomyosarcoma tumors and controls. The identified miRNAs warrant further studies as valuable candidate markers for the differential diagnosis of uterine sarcomas from benign uterine lesions and between uterine sarcoma subtypes. Uterine sarcoma (dpeaa)DE-He213 Carcinosarcoma (dpeaa)DE-He213 Adenosarcoma (dpeaa)DE-He213 Endometrial sarcoma (dpeaa)DE-He213 Leiomyosarcoma (dpeaa)DE-He213 microRNA (dpeaa)DE-He213 Biomarkers (dpeaa)DE-He213 Bakula-Zalewska, Elwira aut Chechlinska, Magdalena aut Goryca, Krzysztof aut Nasierowska-Guttmejer, Anna aut Danska-Bidzinska, Anna aut Bidzinski, Mariusz aut Enthalten in Tumor biology Amsterdam : IOS Press, 1987 34(2013), 4 vom: 05. Apr., Seite 2153-2160 (DE-627)300897855 (DE-600)1483579-4 1423-0380 nnns volume:34 year:2013 number:4 day:05 month:04 pages:2153-2160 https://dx.doi.org/10.1007/s13277-013-0748-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_22 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_63 GBV_ILN_95 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_370 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4338 AR 34 2013 4 05 04 2153-2160
spelling	10.1007/s13277-013-0748-5 doi (DE-627)SPR031128920 (SPR)s13277-013-0748-5-e DE-627 ger DE-627 rakwb eng Kowalewska, Magdalena verfasserin aut microRNAs in uterine sarcomas and mixed epithelial–mesenchymal uterine tumors: a preliminary report 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2013 Abstract Uterine sarcomas and mixed epithelial–mesenchymal uterine tumors are a heterogeneous group of rare tumors for which there are very few diagnostic markers available. As aberrant microRNA (miRNA) expression patterns represent putative diagnostic cancer markers, we aimed to identify miRNA expression profiles of the major uterine sarcoma subtypes and mixed epithelial–mesenchymal tumors of the uterus. Eighty-eight miRNAs were assessed by quantitative RT-PCR in cancerous and non-cancerous tissue samples collected from 29 patients with endometrial sarcoma, leiomyosarcoma, and mixed epithelial–mesenchymal tumors. Tumor and control samples significantly (P < 0.05) differed in the expression of miR-23b, miR-1, let-7f, and let-7c in endometrial sarcomas, and miR-1, let-7c, miR-133b, let-7b, miR-143, let-7a, let-7d, let-7e, let-7g, miR-222, let-7i, and miR-214 in mixed epithelial–mesenchymal tumors. All the significantly changed miRNAs were down-regulated in the malignant tissues as compared to their normal counterparts. This may suggest their tumor suppressor role in these malignancies. No statistically significant changes in miRNA expression levels were found between leiomyosarcoma tumors and controls. The identified miRNAs warrant further studies as valuable candidate markers for the differential diagnosis of uterine sarcomas from benign uterine lesions and between uterine sarcoma subtypes. Uterine sarcoma (dpeaa)DE-He213 Carcinosarcoma (dpeaa)DE-He213 Adenosarcoma (dpeaa)DE-He213 Endometrial sarcoma (dpeaa)DE-He213 Leiomyosarcoma (dpeaa)DE-He213 microRNA (dpeaa)DE-He213 Biomarkers (dpeaa)DE-He213 Bakula-Zalewska, Elwira aut Chechlinska, Magdalena aut Goryca, Krzysztof aut Nasierowska-Guttmejer, Anna aut Danska-Bidzinska, Anna aut Bidzinski, Mariusz aut Enthalten in Tumor biology Amsterdam : IOS Press, 1987 34(2013), 4 vom: 05. Apr., Seite 2153-2160 (DE-627)300897855 (DE-600)1483579-4 1423-0380 nnns volume:34 year:2013 number:4 day:05 month:04 pages:2153-2160 https://dx.doi.org/10.1007/s13277-013-0748-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_22 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_63 GBV_ILN_95 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_370 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4338 AR 34 2013 4 05 04 2153-2160
allfields_unstemmed	10.1007/s13277-013-0748-5 doi (DE-627)SPR031128920 (SPR)s13277-013-0748-5-e DE-627 ger DE-627 rakwb eng Kowalewska, Magdalena verfasserin aut microRNAs in uterine sarcomas and mixed epithelial–mesenchymal uterine tumors: a preliminary report 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2013 Abstract Uterine sarcomas and mixed epithelial–mesenchymal uterine tumors are a heterogeneous group of rare tumors for which there are very few diagnostic markers available. As aberrant microRNA (miRNA) expression patterns represent putative diagnostic cancer markers, we aimed to identify miRNA expression profiles of the major uterine sarcoma subtypes and mixed epithelial–mesenchymal tumors of the uterus. Eighty-eight miRNAs were assessed by quantitative RT-PCR in cancerous and non-cancerous tissue samples collected from 29 patients with endometrial sarcoma, leiomyosarcoma, and mixed epithelial–mesenchymal tumors. Tumor and control samples significantly (P < 0.05) differed in the expression of miR-23b, miR-1, let-7f, and let-7c in endometrial sarcomas, and miR-1, let-7c, miR-133b, let-7b, miR-143, let-7a, let-7d, let-7e, let-7g, miR-222, let-7i, and miR-214 in mixed epithelial–mesenchymal tumors. All the significantly changed miRNAs were down-regulated in the malignant tissues as compared to their normal counterparts. This may suggest their tumor suppressor role in these malignancies. No statistically significant changes in miRNA expression levels were found between leiomyosarcoma tumors and controls. The identified miRNAs warrant further studies as valuable candidate markers for the differential diagnosis of uterine sarcomas from benign uterine lesions and between uterine sarcoma subtypes. Uterine sarcoma (dpeaa)DE-He213 Carcinosarcoma (dpeaa)DE-He213 Adenosarcoma (dpeaa)DE-He213 Endometrial sarcoma (dpeaa)DE-He213 Leiomyosarcoma (dpeaa)DE-He213 microRNA (dpeaa)DE-He213 Biomarkers (dpeaa)DE-He213 Bakula-Zalewska, Elwira aut Chechlinska, Magdalena aut Goryca, Krzysztof aut Nasierowska-Guttmejer, Anna aut Danska-Bidzinska, Anna aut Bidzinski, Mariusz aut Enthalten in Tumor biology Amsterdam : IOS Press, 1987 34(2013), 4 vom: 05. Apr., Seite 2153-2160 (DE-627)300897855 (DE-600)1483579-4 1423-0380 nnns volume:34 year:2013 number:4 day:05 month:04 pages:2153-2160 https://dx.doi.org/10.1007/s13277-013-0748-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_22 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_63 GBV_ILN_95 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_370 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4338 AR 34 2013 4 05 04 2153-2160
allfieldsGer	10.1007/s13277-013-0748-5 doi (DE-627)SPR031128920 (SPR)s13277-013-0748-5-e DE-627 ger DE-627 rakwb eng Kowalewska, Magdalena verfasserin aut microRNAs in uterine sarcomas and mixed epithelial–mesenchymal uterine tumors: a preliminary report 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2013 Abstract Uterine sarcomas and mixed epithelial–mesenchymal uterine tumors are a heterogeneous group of rare tumors for which there are very few diagnostic markers available. As aberrant microRNA (miRNA) expression patterns represent putative diagnostic cancer markers, we aimed to identify miRNA expression profiles of the major uterine sarcoma subtypes and mixed epithelial–mesenchymal tumors of the uterus. Eighty-eight miRNAs were assessed by quantitative RT-PCR in cancerous and non-cancerous tissue samples collected from 29 patients with endometrial sarcoma, leiomyosarcoma, and mixed epithelial–mesenchymal tumors. Tumor and control samples significantly (P < 0.05) differed in the expression of miR-23b, miR-1, let-7f, and let-7c in endometrial sarcomas, and miR-1, let-7c, miR-133b, let-7b, miR-143, let-7a, let-7d, let-7e, let-7g, miR-222, let-7i, and miR-214 in mixed epithelial–mesenchymal tumors. All the significantly changed miRNAs were down-regulated in the malignant tissues as compared to their normal counterparts. This may suggest their tumor suppressor role in these malignancies. No statistically significant changes in miRNA expression levels were found between leiomyosarcoma tumors and controls. The identified miRNAs warrant further studies as valuable candidate markers for the differential diagnosis of uterine sarcomas from benign uterine lesions and between uterine sarcoma subtypes. Uterine sarcoma (dpeaa)DE-He213 Carcinosarcoma (dpeaa)DE-He213 Adenosarcoma (dpeaa)DE-He213 Endometrial sarcoma (dpeaa)DE-He213 Leiomyosarcoma (dpeaa)DE-He213 microRNA (dpeaa)DE-He213 Biomarkers (dpeaa)DE-He213 Bakula-Zalewska, Elwira aut Chechlinska, Magdalena aut Goryca, Krzysztof aut Nasierowska-Guttmejer, Anna aut Danska-Bidzinska, Anna aut Bidzinski, Mariusz aut Enthalten in Tumor biology Amsterdam : IOS Press, 1987 34(2013), 4 vom: 05. Apr., Seite 2153-2160 (DE-627)300897855 (DE-600)1483579-4 1423-0380 nnns volume:34 year:2013 number:4 day:05 month:04 pages:2153-2160 https://dx.doi.org/10.1007/s13277-013-0748-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_22 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_63 GBV_ILN_95 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_370 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4338 AR 34 2013 4 05 04 2153-2160
allfieldsSound	10.1007/s13277-013-0748-5 doi (DE-627)SPR031128920 (SPR)s13277-013-0748-5-e DE-627 ger DE-627 rakwb eng Kowalewska, Magdalena verfasserin aut microRNAs in uterine sarcomas and mixed epithelial–mesenchymal uterine tumors: a preliminary report 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2013 Abstract Uterine sarcomas and mixed epithelial–mesenchymal uterine tumors are a heterogeneous group of rare tumors for which there are very few diagnostic markers available. As aberrant microRNA (miRNA) expression patterns represent putative diagnostic cancer markers, we aimed to identify miRNA expression profiles of the major uterine sarcoma subtypes and mixed epithelial–mesenchymal tumors of the uterus. Eighty-eight miRNAs were assessed by quantitative RT-PCR in cancerous and non-cancerous tissue samples collected from 29 patients with endometrial sarcoma, leiomyosarcoma, and mixed epithelial–mesenchymal tumors. Tumor and control samples significantly (P < 0.05) differed in the expression of miR-23b, miR-1, let-7f, and let-7c in endometrial sarcomas, and miR-1, let-7c, miR-133b, let-7b, miR-143, let-7a, let-7d, let-7e, let-7g, miR-222, let-7i, and miR-214 in mixed epithelial–mesenchymal tumors. All the significantly changed miRNAs were down-regulated in the malignant tissues as compared to their normal counterparts. This may suggest their tumor suppressor role in these malignancies. No statistically significant changes in miRNA expression levels were found between leiomyosarcoma tumors and controls. The identified miRNAs warrant further studies as valuable candidate markers for the differential diagnosis of uterine sarcomas from benign uterine lesions and between uterine sarcoma subtypes. Uterine sarcoma (dpeaa)DE-He213 Carcinosarcoma (dpeaa)DE-He213 Adenosarcoma (dpeaa)DE-He213 Endometrial sarcoma (dpeaa)DE-He213 Leiomyosarcoma (dpeaa)DE-He213 microRNA (dpeaa)DE-He213 Biomarkers (dpeaa)DE-He213 Bakula-Zalewska, Elwira aut Chechlinska, Magdalena aut Goryca, Krzysztof aut Nasierowska-Guttmejer, Anna aut Danska-Bidzinska, Anna aut Bidzinski, Mariusz aut Enthalten in Tumor biology Amsterdam : IOS Press, 1987 34(2013), 4 vom: 05. Apr., Seite 2153-2160 (DE-627)300897855 (DE-600)1483579-4 1423-0380 nnns volume:34 year:2013 number:4 day:05 month:04 pages:2153-2160 https://dx.doi.org/10.1007/s13277-013-0748-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_22 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_63 GBV_ILN_95 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_370 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4338 AR 34 2013 4 05 04 2153-2160
language	English
source	Enthalten in Tumor biology 34(2013), 4 vom: 05. Apr., Seite 2153-2160 volume:34 year:2013 number:4 day:05 month:04 pages:2153-2160
sourceStr	Enthalten in Tumor biology 34(2013), 4 vom: 05. Apr., Seite 2153-2160 volume:34 year:2013 number:4 day:05 month:04 pages:2153-2160
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Uterine sarcoma Carcinosarcoma Adenosarcoma Endometrial sarcoma Leiomyosarcoma microRNA Biomarkers
isfreeaccess_bool	true
container_title	Tumor biology
authorswithroles_txt_mv	Kowalewska, Magdalena @@aut@@ Bakula-Zalewska, Elwira @@aut@@ Chechlinska, Magdalena @@aut@@ Goryca, Krzysztof @@aut@@ Nasierowska-Guttmejer, Anna @@aut@@ Danska-Bidzinska, Anna @@aut@@ Bidzinski, Mariusz @@aut@@
publishDateDaySort_date	2013-04-05T00:00:00Z
hierarchy_top_id	300897855
id	SPR031128920
language_de	englisch
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author	Kowalewska, Magdalena
spellingShingle	Kowalewska, Magdalena misc Uterine sarcoma misc Carcinosarcoma misc Adenosarcoma misc Endometrial sarcoma misc Leiomyosarcoma misc microRNA misc Biomarkers microRNAs in uterine sarcomas and mixed epithelial–mesenchymal uterine tumors: a preliminary report
authorStr	Kowalewska, Magdalena
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topic_title	microRNAs in uterine sarcomas and mixed epithelial–mesenchymal uterine tumors: a preliminary report Uterine sarcoma (dpeaa)DE-He213 Carcinosarcoma (dpeaa)DE-He213 Adenosarcoma (dpeaa)DE-He213 Endometrial sarcoma (dpeaa)DE-He213 Leiomyosarcoma (dpeaa)DE-He213 microRNA (dpeaa)DE-He213 Biomarkers (dpeaa)DE-He213
topic	misc Uterine sarcoma misc Carcinosarcoma misc Adenosarcoma misc Endometrial sarcoma misc Leiomyosarcoma misc microRNA misc Biomarkers
topic_unstemmed	misc Uterine sarcoma misc Carcinosarcoma misc Adenosarcoma misc Endometrial sarcoma misc Leiomyosarcoma misc microRNA misc Biomarkers
topic_browse	misc Uterine sarcoma misc Carcinosarcoma misc Adenosarcoma misc Endometrial sarcoma misc Leiomyosarcoma misc microRNA misc Biomarkers
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title	microRNAs in uterine sarcomas and mixed epithelial–mesenchymal uterine tumors: a preliminary report
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title_full	microRNAs in uterine sarcomas and mixed epithelial–mesenchymal uterine tumors: a preliminary report
author_sort	Kowalewska, Magdalena
journal	Tumor biology
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author_browse	Kowalewska, Magdalena Bakula-Zalewska, Elwira Chechlinska, Magdalena Goryca, Krzysztof Nasierowska-Guttmejer, Anna Danska-Bidzinska, Anna Bidzinski, Mariusz
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author-letter	Kowalewska, Magdalena
doi_str_mv	10.1007/s13277-013-0748-5
title_sort	micrornas in uterine sarcomas and mixed epithelial–mesenchymal uterine tumors: a preliminary report
title_auth	microRNAs in uterine sarcomas and mixed epithelial–mesenchymal uterine tumors: a preliminary report
abstract	Abstract Uterine sarcomas and mixed epithelial–mesenchymal uterine tumors are a heterogeneous group of rare tumors for which there are very few diagnostic markers available. As aberrant microRNA (miRNA) expression patterns represent putative diagnostic cancer markers, we aimed to identify miRNA expression profiles of the major uterine sarcoma subtypes and mixed epithelial–mesenchymal tumors of the uterus. Eighty-eight miRNAs were assessed by quantitative RT-PCR in cancerous and non-cancerous tissue samples collected from 29 patients with endometrial sarcoma, leiomyosarcoma, and mixed epithelial–mesenchymal tumors. Tumor and control samples significantly (P < 0.05) differed in the expression of miR-23b, miR-1, let-7f, and let-7c in endometrial sarcomas, and miR-1, let-7c, miR-133b, let-7b, miR-143, let-7a, let-7d, let-7e, let-7g, miR-222, let-7i, and miR-214 in mixed epithelial–mesenchymal tumors. All the significantly changed miRNAs were down-regulated in the malignant tissues as compared to their normal counterparts. This may suggest their tumor suppressor role in these malignancies. No statistically significant changes in miRNA expression levels were found between leiomyosarcoma tumors and controls. The identified miRNAs warrant further studies as valuable candidate markers for the differential diagnosis of uterine sarcomas from benign uterine lesions and between uterine sarcoma subtypes. © The Author(s) 2013
abstractGer	Abstract Uterine sarcomas and mixed epithelial–mesenchymal uterine tumors are a heterogeneous group of rare tumors for which there are very few diagnostic markers available. As aberrant microRNA (miRNA) expression patterns represent putative diagnostic cancer markers, we aimed to identify miRNA expression profiles of the major uterine sarcoma subtypes and mixed epithelial–mesenchymal tumors of the uterus. Eighty-eight miRNAs were assessed by quantitative RT-PCR in cancerous and non-cancerous tissue samples collected from 29 patients with endometrial sarcoma, leiomyosarcoma, and mixed epithelial–mesenchymal tumors. Tumor and control samples significantly (P < 0.05) differed in the expression of miR-23b, miR-1, let-7f, and let-7c in endometrial sarcomas, and miR-1, let-7c, miR-133b, let-7b, miR-143, let-7a, let-7d, let-7e, let-7g, miR-222, let-7i, and miR-214 in mixed epithelial–mesenchymal tumors. All the significantly changed miRNAs were down-regulated in the malignant tissues as compared to their normal counterparts. This may suggest their tumor suppressor role in these malignancies. No statistically significant changes in miRNA expression levels were found between leiomyosarcoma tumors and controls. The identified miRNAs warrant further studies as valuable candidate markers for the differential diagnosis of uterine sarcomas from benign uterine lesions and between uterine sarcoma subtypes. © The Author(s) 2013
abstract_unstemmed	Abstract Uterine sarcomas and mixed epithelial–mesenchymal uterine tumors are a heterogeneous group of rare tumors for which there are very few diagnostic markers available. As aberrant microRNA (miRNA) expression patterns represent putative diagnostic cancer markers, we aimed to identify miRNA expression profiles of the major uterine sarcoma subtypes and mixed epithelial–mesenchymal tumors of the uterus. Eighty-eight miRNAs were assessed by quantitative RT-PCR in cancerous and non-cancerous tissue samples collected from 29 patients with endometrial sarcoma, leiomyosarcoma, and mixed epithelial–mesenchymal tumors. Tumor and control samples significantly (P < 0.05) differed in the expression of miR-23b, miR-1, let-7f, and let-7c in endometrial sarcomas, and miR-1, let-7c, miR-133b, let-7b, miR-143, let-7a, let-7d, let-7e, let-7g, miR-222, let-7i, and miR-214 in mixed epithelial–mesenchymal tumors. All the significantly changed miRNAs were down-regulated in the malignant tissues as compared to their normal counterparts. This may suggest their tumor suppressor role in these malignancies. No statistically significant changes in miRNA expression levels were found between leiomyosarcoma tumors and controls. The identified miRNAs warrant further studies as valuable candidate markers for the differential diagnosis of uterine sarcomas from benign uterine lesions and between uterine sarcoma subtypes. © The Author(s) 2013
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title_short	microRNAs in uterine sarcomas and mixed epithelial–mesenchymal uterine tumors: a preliminary report
url	https://dx.doi.org/10.1007/s13277-013-0748-5
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author2	Bakula-Zalewska, Elwira Chechlinska, Magdalena Goryca, Krzysztof Nasierowska-Guttmejer, Anna Danska-Bidzinska, Anna Bidzinski, Mariusz
author2Str	Bakula-Zalewska, Elwira Chechlinska, Magdalena Goryca, Krzysztof Nasierowska-Guttmejer, Anna Danska-Bidzinska, Anna Bidzinski, Mariusz
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microRNAs in uterine sarcomas and mixed epithelial–mesenchymal uterine tumors: a preliminary report

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