Krüppel-like factor 5: a novel biomarker for lymph node metastasis and recurrence in supraglottic squamous cell laryngeal carcinoma

Abstract Krüppel-like factor 5 (KLF5), a zinc finger-containing transcription factor, is involved in important biological processes including cell transformation, proliferation, and carcinogenesis. However, its clinical significance has remained largely unknown in laryngeal cancer. Here, specimens f...
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Autor*in:	Mao, Xionghui [verfasserIn] Miao, Susheng He, Hongjiang Miao, Suping Pei, Rong Yang, Xianguang Xiu, Chen Song, Kaibin Zhang, Jian Sun, Ji Jia, Shenshan Guan, Qiang

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	Laryngeal carcinoma KLF 5 (Krüppel-like factor 5) ILK (integrin-linked kinase) EMT (epithelial–mesenchymal transition) Biomarker

Anmerkung:	© International Society of Oncology and BioMarkers (ISOBM) 2013

Übergeordnetes Werk:	Enthalten in: Tumor biology - Amsterdam : IOS Press, 1987, 35(2013), 1 vom: 23. Aug., Seite 623-629
Übergeordnetes Werk:	volume:35 ; year:2013 ; number:1 ; day:23 ; month:08 ; pages:623-629

Links:	Volltext

DOI / URN:	10.1007/s13277-013-1086-3

Katalog-ID:	SPR03113260X

Internformat


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allfields	10.1007/s13277-013-1086-3 doi (DE-627)SPR03113260X (SPR)s13277-013-1086-3-e DE-627 ger DE-627 rakwb eng Mao, Xionghui verfasserin aut Krüppel-like factor 5: a novel biomarker for lymph node metastasis and recurrence in supraglottic squamous cell laryngeal carcinoma 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © International Society of Oncology and BioMarkers (ISOBM) 2013 Abstract Krüppel-like factor 5 (KLF5), a zinc finger-containing transcription factor, is involved in important biological processes including cell transformation, proliferation, and carcinogenesis. However, its clinical significance has remained largely unknown in laryngeal cancer. Here, specimens from 144 patients with laryngeal tumors were investigated by immunohistochemical staining for KLF5, integrin-linked kinase (ILK), and E-cadherin expressions. A clinicopathological study revealed that the KLF5 expression level in tumor cells was significantly correlated with lymph node metastasis (P < 0.05) and local recurrence (P < 0.05). In addition, KLF5, ILK, and E-cadherin (epithelial–mesenchymal transition (EMT) biomarker) expressions were correlated with each other. These findings suggest that KLF5 may be an epithelial–mesenchymal transition-associated biomarker in human laryngeal carcinomas and play important roles in the progression of laryngeal carcinomas. KLF5 immunoreactivity is therefore considered a potential lymph node metastasis and recurrence factor in human laryngeal cancers. In addition, the KLF5-mediated pathway is a potential target for elimination of laryngeal cancer in the future. Laryngeal carcinoma (dpeaa)DE-He213 KLF 5 (Krüppel-like factor 5) (dpeaa)DE-He213 ILK (integrin-linked kinase) (dpeaa)DE-He213 EMT (epithelial–mesenchymal transition) (dpeaa)DE-He213 Biomarker (dpeaa)DE-He213 Miao, Susheng aut He, Hongjiang aut Miao, Suping aut Pei, Rong aut Yang, Xianguang aut Xiu, Chen aut Song, Kaibin aut Zhang, Jian aut Sun, Ji aut Jia, Shenshan aut Guan, Qiang aut Enthalten in Tumor biology Amsterdam : IOS Press, 1987 35(2013), 1 vom: 23. Aug., Seite 623-629 (DE-627)300897855 (DE-600)1483579-4 1423-0380 nnns volume:35 year:2013 number:1 day:23 month:08 pages:623-629 https://dx.doi.org/10.1007/s13277-013-1086-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_22 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_63 GBV_ILN_95 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_370 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4338 AR 35 2013 1 23 08 623-629
spelling	10.1007/s13277-013-1086-3 doi (DE-627)SPR03113260X (SPR)s13277-013-1086-3-e DE-627 ger DE-627 rakwb eng Mao, Xionghui verfasserin aut Krüppel-like factor 5: a novel biomarker for lymph node metastasis and recurrence in supraglottic squamous cell laryngeal carcinoma 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © International Society of Oncology and BioMarkers (ISOBM) 2013 Abstract Krüppel-like factor 5 (KLF5), a zinc finger-containing transcription factor, is involved in important biological processes including cell transformation, proliferation, and carcinogenesis. However, its clinical significance has remained largely unknown in laryngeal cancer. Here, specimens from 144 patients with laryngeal tumors were investigated by immunohistochemical staining for KLF5, integrin-linked kinase (ILK), and E-cadherin expressions. A clinicopathological study revealed that the KLF5 expression level in tumor cells was significantly correlated with lymph node metastasis (P < 0.05) and local recurrence (P < 0.05). In addition, KLF5, ILK, and E-cadherin (epithelial–mesenchymal transition (EMT) biomarker) expressions were correlated with each other. These findings suggest that KLF5 may be an epithelial–mesenchymal transition-associated biomarker in human laryngeal carcinomas and play important roles in the progression of laryngeal carcinomas. KLF5 immunoreactivity is therefore considered a potential lymph node metastasis and recurrence factor in human laryngeal cancers. In addition, the KLF5-mediated pathway is a potential target for elimination of laryngeal cancer in the future. Laryngeal carcinoma (dpeaa)DE-He213 KLF 5 (Krüppel-like factor 5) (dpeaa)DE-He213 ILK (integrin-linked kinase) (dpeaa)DE-He213 EMT (epithelial–mesenchymal transition) (dpeaa)DE-He213 Biomarker (dpeaa)DE-He213 Miao, Susheng aut He, Hongjiang aut Miao, Suping aut Pei, Rong aut Yang, Xianguang aut Xiu, Chen aut Song, Kaibin aut Zhang, Jian aut Sun, Ji aut Jia, Shenshan aut Guan, Qiang aut Enthalten in Tumor biology Amsterdam : IOS Press, 1987 35(2013), 1 vom: 23. Aug., Seite 623-629 (DE-627)300897855 (DE-600)1483579-4 1423-0380 nnns volume:35 year:2013 number:1 day:23 month:08 pages:623-629 https://dx.doi.org/10.1007/s13277-013-1086-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_22 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_63 GBV_ILN_95 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_370 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4338 AR 35 2013 1 23 08 623-629
allfields_unstemmed	10.1007/s13277-013-1086-3 doi (DE-627)SPR03113260X (SPR)s13277-013-1086-3-e DE-627 ger DE-627 rakwb eng Mao, Xionghui verfasserin aut Krüppel-like factor 5: a novel biomarker for lymph node metastasis and recurrence in supraglottic squamous cell laryngeal carcinoma 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © International Society of Oncology and BioMarkers (ISOBM) 2013 Abstract Krüppel-like factor 5 (KLF5), a zinc finger-containing transcription factor, is involved in important biological processes including cell transformation, proliferation, and carcinogenesis. However, its clinical significance has remained largely unknown in laryngeal cancer. Here, specimens from 144 patients with laryngeal tumors were investigated by immunohistochemical staining for KLF5, integrin-linked kinase (ILK), and E-cadherin expressions. A clinicopathological study revealed that the KLF5 expression level in tumor cells was significantly correlated with lymph node metastasis (P < 0.05) and local recurrence (P < 0.05). In addition, KLF5, ILK, and E-cadherin (epithelial–mesenchymal transition (EMT) biomarker) expressions were correlated with each other. These findings suggest that KLF5 may be an epithelial–mesenchymal transition-associated biomarker in human laryngeal carcinomas and play important roles in the progression of laryngeal carcinomas. KLF5 immunoreactivity is therefore considered a potential lymph node metastasis and recurrence factor in human laryngeal cancers. In addition, the KLF5-mediated pathway is a potential target for elimination of laryngeal cancer in the future. Laryngeal carcinoma (dpeaa)DE-He213 KLF 5 (Krüppel-like factor 5) (dpeaa)DE-He213 ILK (integrin-linked kinase) (dpeaa)DE-He213 EMT (epithelial–mesenchymal transition) (dpeaa)DE-He213 Biomarker (dpeaa)DE-He213 Miao, Susheng aut He, Hongjiang aut Miao, Suping aut Pei, Rong aut Yang, Xianguang aut Xiu, Chen aut Song, Kaibin aut Zhang, Jian aut Sun, Ji aut Jia, Shenshan aut Guan, Qiang aut Enthalten in Tumor biology Amsterdam : IOS Press, 1987 35(2013), 1 vom: 23. Aug., Seite 623-629 (DE-627)300897855 (DE-600)1483579-4 1423-0380 nnns volume:35 year:2013 number:1 day:23 month:08 pages:623-629 https://dx.doi.org/10.1007/s13277-013-1086-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_22 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_63 GBV_ILN_95 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_370 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4338 AR 35 2013 1 23 08 623-629
allfieldsGer	10.1007/s13277-013-1086-3 doi (DE-627)SPR03113260X (SPR)s13277-013-1086-3-e DE-627 ger DE-627 rakwb eng Mao, Xionghui verfasserin aut Krüppel-like factor 5: a novel biomarker for lymph node metastasis and recurrence in supraglottic squamous cell laryngeal carcinoma 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © International Society of Oncology and BioMarkers (ISOBM) 2013 Abstract Krüppel-like factor 5 (KLF5), a zinc finger-containing transcription factor, is involved in important biological processes including cell transformation, proliferation, and carcinogenesis. However, its clinical significance has remained largely unknown in laryngeal cancer. Here, specimens from 144 patients with laryngeal tumors were investigated by immunohistochemical staining for KLF5, integrin-linked kinase (ILK), and E-cadherin expressions. A clinicopathological study revealed that the KLF5 expression level in tumor cells was significantly correlated with lymph node metastasis (P < 0.05) and local recurrence (P < 0.05). In addition, KLF5, ILK, and E-cadherin (epithelial–mesenchymal transition (EMT) biomarker) expressions were correlated with each other. These findings suggest that KLF5 may be an epithelial–mesenchymal transition-associated biomarker in human laryngeal carcinomas and play important roles in the progression of laryngeal carcinomas. KLF5 immunoreactivity is therefore considered a potential lymph node metastasis and recurrence factor in human laryngeal cancers. In addition, the KLF5-mediated pathway is a potential target for elimination of laryngeal cancer in the future. Laryngeal carcinoma (dpeaa)DE-He213 KLF 5 (Krüppel-like factor 5) (dpeaa)DE-He213 ILK (integrin-linked kinase) (dpeaa)DE-He213 EMT (epithelial–mesenchymal transition) (dpeaa)DE-He213 Biomarker (dpeaa)DE-He213 Miao, Susheng aut He, Hongjiang aut Miao, Suping aut Pei, Rong aut Yang, Xianguang aut Xiu, Chen aut Song, Kaibin aut Zhang, Jian aut Sun, Ji aut Jia, Shenshan aut Guan, Qiang aut Enthalten in Tumor biology Amsterdam : IOS Press, 1987 35(2013), 1 vom: 23. Aug., Seite 623-629 (DE-627)300897855 (DE-600)1483579-4 1423-0380 nnns volume:35 year:2013 number:1 day:23 month:08 pages:623-629 https://dx.doi.org/10.1007/s13277-013-1086-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_22 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_63 GBV_ILN_95 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_370 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4338 AR 35 2013 1 23 08 623-629
allfieldsSound	10.1007/s13277-013-1086-3 doi (DE-627)SPR03113260X (SPR)s13277-013-1086-3-e DE-627 ger DE-627 rakwb eng Mao, Xionghui verfasserin aut Krüppel-like factor 5: a novel biomarker for lymph node metastasis and recurrence in supraglottic squamous cell laryngeal carcinoma 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © International Society of Oncology and BioMarkers (ISOBM) 2013 Abstract Krüppel-like factor 5 (KLF5), a zinc finger-containing transcription factor, is involved in important biological processes including cell transformation, proliferation, and carcinogenesis. However, its clinical significance has remained largely unknown in laryngeal cancer. Here, specimens from 144 patients with laryngeal tumors were investigated by immunohistochemical staining for KLF5, integrin-linked kinase (ILK), and E-cadherin expressions. A clinicopathological study revealed that the KLF5 expression level in tumor cells was significantly correlated with lymph node metastasis (P < 0.05) and local recurrence (P < 0.05). In addition, KLF5, ILK, and E-cadherin (epithelial–mesenchymal transition (EMT) biomarker) expressions were correlated with each other. These findings suggest that KLF5 may be an epithelial–mesenchymal transition-associated biomarker in human laryngeal carcinomas and play important roles in the progression of laryngeal carcinomas. KLF5 immunoreactivity is therefore considered a potential lymph node metastasis and recurrence factor in human laryngeal cancers. In addition, the KLF5-mediated pathway is a potential target for elimination of laryngeal cancer in the future. Laryngeal carcinoma (dpeaa)DE-He213 KLF 5 (Krüppel-like factor 5) (dpeaa)DE-He213 ILK (integrin-linked kinase) (dpeaa)DE-He213 EMT (epithelial–mesenchymal transition) (dpeaa)DE-He213 Biomarker (dpeaa)DE-He213 Miao, Susheng aut He, Hongjiang aut Miao, Suping aut Pei, Rong aut Yang, Xianguang aut Xiu, Chen aut Song, Kaibin aut Zhang, Jian aut Sun, Ji aut Jia, Shenshan aut Guan, Qiang aut Enthalten in Tumor biology Amsterdam : IOS Press, 1987 35(2013), 1 vom: 23. Aug., Seite 623-629 (DE-627)300897855 (DE-600)1483579-4 1423-0380 nnns volume:35 year:2013 number:1 day:23 month:08 pages:623-629 https://dx.doi.org/10.1007/s13277-013-1086-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_22 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_63 GBV_ILN_95 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_370 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4338 AR 35 2013 1 23 08 623-629
language	English
source	Enthalten in Tumor biology 35(2013), 1 vom: 23. Aug., Seite 623-629 volume:35 year:2013 number:1 day:23 month:08 pages:623-629
sourceStr	Enthalten in Tumor biology 35(2013), 1 vom: 23. Aug., Seite 623-629 volume:35 year:2013 number:1 day:23 month:08 pages:623-629
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Laryngeal carcinoma KLF 5 (Krüppel-like factor 5) ILK (integrin-linked kinase) EMT (epithelial–mesenchymal transition) Biomarker
isfreeaccess_bool	false
container_title	Tumor biology
authorswithroles_txt_mv	Mao, Xionghui @@aut@@ Miao, Susheng @@aut@@ He, Hongjiang @@aut@@ Miao, Suping @@aut@@ Pei, Rong @@aut@@ Yang, Xianguang @@aut@@ Xiu, Chen @@aut@@ Song, Kaibin @@aut@@ Zhang, Jian @@aut@@ Sun, Ji @@aut@@ Jia, Shenshan @@aut@@ Guan, Qiang @@aut@@
publishDateDaySort_date	2013-08-23T00:00:00Z
hierarchy_top_id	300897855
id	SPR03113260X
language_de	englisch
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author	Mao, Xionghui
spellingShingle	Mao, Xionghui misc Laryngeal carcinoma misc KLF 5 (Krüppel-like factor 5) misc ILK (integrin-linked kinase) misc EMT (epithelial–mesenchymal transition) misc Biomarker Krüppel-like factor 5: a novel biomarker for lymph node metastasis and recurrence in supraglottic squamous cell laryngeal carcinoma
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topic_title	Krüppel-like factor 5: a novel biomarker for lymph node metastasis and recurrence in supraglottic squamous cell laryngeal carcinoma Laryngeal carcinoma (dpeaa)DE-He213 KLF 5 (Krüppel-like factor 5) (dpeaa)DE-He213 ILK (integrin-linked kinase) (dpeaa)DE-He213 EMT (epithelial–mesenchymal transition) (dpeaa)DE-He213 Biomarker (dpeaa)DE-He213
topic	misc Laryngeal carcinoma misc KLF 5 (Krüppel-like factor 5) misc ILK (integrin-linked kinase) misc EMT (epithelial–mesenchymal transition) misc Biomarker
topic_unstemmed	misc Laryngeal carcinoma misc KLF 5 (Krüppel-like factor 5) misc ILK (integrin-linked kinase) misc EMT (epithelial–mesenchymal transition) misc Biomarker
topic_browse	misc Laryngeal carcinoma misc KLF 5 (Krüppel-like factor 5) misc ILK (integrin-linked kinase) misc EMT (epithelial–mesenchymal transition) misc Biomarker
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title	Krüppel-like factor 5: a novel biomarker for lymph node metastasis and recurrence in supraglottic squamous cell laryngeal carcinoma
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title_full	Krüppel-like factor 5: a novel biomarker for lymph node metastasis and recurrence in supraglottic squamous cell laryngeal carcinoma
author_sort	Mao, Xionghui
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author_browse	Mao, Xionghui Miao, Susheng He, Hongjiang Miao, Suping Pei, Rong Yang, Xianguang Xiu, Chen Song, Kaibin Zhang, Jian Sun, Ji Jia, Shenshan Guan, Qiang
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author-letter	Mao, Xionghui
doi_str_mv	10.1007/s13277-013-1086-3
title_sort	krüppel-like factor 5: a novel biomarker for lymph node metastasis and recurrence in supraglottic squamous cell laryngeal carcinoma
title_auth	Krüppel-like factor 5: a novel biomarker for lymph node metastasis and recurrence in supraglottic squamous cell laryngeal carcinoma
abstract	Abstract Krüppel-like factor 5 (KLF5), a zinc finger-containing transcription factor, is involved in important biological processes including cell transformation, proliferation, and carcinogenesis. However, its clinical significance has remained largely unknown in laryngeal cancer. Here, specimens from 144 patients with laryngeal tumors were investigated by immunohistochemical staining for KLF5, integrin-linked kinase (ILK), and E-cadherin expressions. A clinicopathological study revealed that the KLF5 expression level in tumor cells was significantly correlated with lymph node metastasis (P < 0.05) and local recurrence (P < 0.05). In addition, KLF5, ILK, and E-cadherin (epithelial–mesenchymal transition (EMT) biomarker) expressions were correlated with each other. These findings suggest that KLF5 may be an epithelial–mesenchymal transition-associated biomarker in human laryngeal carcinomas and play important roles in the progression of laryngeal carcinomas. KLF5 immunoreactivity is therefore considered a potential lymph node metastasis and recurrence factor in human laryngeal cancers. In addition, the KLF5-mediated pathway is a potential target for elimination of laryngeal cancer in the future. © International Society of Oncology and BioMarkers (ISOBM) 2013
abstractGer	Abstract Krüppel-like factor 5 (KLF5), a zinc finger-containing transcription factor, is involved in important biological processes including cell transformation, proliferation, and carcinogenesis. However, its clinical significance has remained largely unknown in laryngeal cancer. Here, specimens from 144 patients with laryngeal tumors were investigated by immunohistochemical staining for KLF5, integrin-linked kinase (ILK), and E-cadherin expressions. A clinicopathological study revealed that the KLF5 expression level in tumor cells was significantly correlated with lymph node metastasis (P < 0.05) and local recurrence (P < 0.05). In addition, KLF5, ILK, and E-cadherin (epithelial–mesenchymal transition (EMT) biomarker) expressions were correlated with each other. These findings suggest that KLF5 may be an epithelial–mesenchymal transition-associated biomarker in human laryngeal carcinomas and play important roles in the progression of laryngeal carcinomas. KLF5 immunoreactivity is therefore considered a potential lymph node metastasis and recurrence factor in human laryngeal cancers. In addition, the KLF5-mediated pathway is a potential target for elimination of laryngeal cancer in the future. © International Society of Oncology and BioMarkers (ISOBM) 2013
abstract_unstemmed	Abstract Krüppel-like factor 5 (KLF5), a zinc finger-containing transcription factor, is involved in important biological processes including cell transformation, proliferation, and carcinogenesis. However, its clinical significance has remained largely unknown in laryngeal cancer. Here, specimens from 144 patients with laryngeal tumors were investigated by immunohistochemical staining for KLF5, integrin-linked kinase (ILK), and E-cadherin expressions. A clinicopathological study revealed that the KLF5 expression level in tumor cells was significantly correlated with lymph node metastasis (P < 0.05) and local recurrence (P < 0.05). In addition, KLF5, ILK, and E-cadherin (epithelial–mesenchymal transition (EMT) biomarker) expressions were correlated with each other. These findings suggest that KLF5 may be an epithelial–mesenchymal transition-associated biomarker in human laryngeal carcinomas and play important roles in the progression of laryngeal carcinomas. KLF5 immunoreactivity is therefore considered a potential lymph node metastasis and recurrence factor in human laryngeal cancers. In addition, the KLF5-mediated pathway is a potential target for elimination of laryngeal cancer in the future. © International Society of Oncology and BioMarkers (ISOBM) 2013
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title_short	Krüppel-like factor 5: a novel biomarker for lymph node metastasis and recurrence in supraglottic squamous cell laryngeal carcinoma
url	https://dx.doi.org/10.1007/s13277-013-1086-3
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author2	Miao, Susheng He, Hongjiang Miao, Suping Pei, Rong Yang, Xianguang Xiu, Chen Song, Kaibin Zhang, Jian Sun, Ji Jia, Shenshan Guan, Qiang
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Krüppel-like factor 5: a novel biomarker for lymph node metastasis and recurrence in supraglottic squamous cell laryngeal carcinoma

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