Antitumor activities of ginseng polysaccharide in C57BL/6 mice with Lewis lung carcinoma

Abstract In the present study, we prepared ginseng polysaccharide (GP) and evaluated its antitumor and immunomodulatory activities in C57BL/6 mice bearing with Lewis lung carcinoma (LLC). Administration of GP (50, 100, and 200 mg/kg) could not only significantly inhibit the growth of transplantable...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Zhou, Xiao [verfasserIn] Shi, Huaiyin Jiang, Gening Zhou, Yongan Xu, Jianfang

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	Ginseng polysaccharide Antitumor Immunomodulatory

Anmerkung:	© International Society of Oncology and BioMarkers (ISOBM) 2014

Übergeordnetes Werk:	Enthalten in: Tumor biology - Amsterdam : IOS Press, 1987, 35(2014), 12 vom: 11. Sept., Seite 12561-12566
Übergeordnetes Werk:	volume:35 ; year:2014 ; number:12 ; day:11 ; month:09 ; pages:12561-12566

Links:	Volltext

DOI / URN:	10.1007/s13277-014-2576-7

Katalog-ID:	SPR03113694X

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allfields	10.1007/s13277-014-2576-7 doi (DE-627)SPR03113694X (SPR)s13277-014-2576-7-e DE-627 ger DE-627 rakwb eng Zhou, Xiao verfasserin aut Antitumor activities of ginseng polysaccharide in C57BL/6 mice with Lewis lung carcinoma 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © International Society of Oncology and BioMarkers (ISOBM) 2014 Abstract In the present study, we prepared ginseng polysaccharide (GP) and evaluated its antitumor and immunomodulatory activities in C57BL/6 mice bearing with Lewis lung carcinoma (LLC). Administration of GP (50, 100, and 200 mg/kg) could not only significantly inhibit the growth of transplantable LLC tumor in C57BL/6 mice but also remarkably increase relative weight of spleen and thymus, splenocytes proliferation, and the ratio of $ CD4^{+} $/$ CD8^{+} $ T lymphocyte in peripheral blood in LLC-bearing mice. Furthermore, the serum IL-2 and IFN-γ production and NK cytolytic activity were also prompted in LLC-bearing mice in response to GP treatment at three doses. Additionally, GP showed no side effects such as weight loss in body weight and internal organs (lung, liver, kidney, and heart) as well as inactivity during the experiment. Therefore, GP might be conveniently exploited to be good immune-stimulating modifiers and had the potential value for tumor therapy. Ginseng polysaccharide (dpeaa)DE-He213 Antitumor (dpeaa)DE-He213 Immunomodulatory (dpeaa)DE-He213 Shi, Huaiyin aut Jiang, Gening aut Zhou, Yongan aut Xu, Jianfang aut Enthalten in Tumor biology Amsterdam : IOS Press, 1987 35(2014), 12 vom: 11. Sept., Seite 12561-12566 (DE-627)300897855 (DE-600)1483579-4 1423-0380 nnns volume:35 year:2014 number:12 day:11 month:09 pages:12561-12566 https://dx.doi.org/10.1007/s13277-014-2576-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_22 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_63 GBV_ILN_95 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_187 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_370 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4338 AR 35 2014 12 11 09 12561-12566
spelling	10.1007/s13277-014-2576-7 doi (DE-627)SPR03113694X (SPR)s13277-014-2576-7-e DE-627 ger DE-627 rakwb eng Zhou, Xiao verfasserin aut Antitumor activities of ginseng polysaccharide in C57BL/6 mice with Lewis lung carcinoma 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © International Society of Oncology and BioMarkers (ISOBM) 2014 Abstract In the present study, we prepared ginseng polysaccharide (GP) and evaluated its antitumor and immunomodulatory activities in C57BL/6 mice bearing with Lewis lung carcinoma (LLC). Administration of GP (50, 100, and 200 mg/kg) could not only significantly inhibit the growth of transplantable LLC tumor in C57BL/6 mice but also remarkably increase relative weight of spleen and thymus, splenocytes proliferation, and the ratio of $ CD4^{+} $/$ CD8^{+} $ T lymphocyte in peripheral blood in LLC-bearing mice. Furthermore, the serum IL-2 and IFN-γ production and NK cytolytic activity were also prompted in LLC-bearing mice in response to GP treatment at three doses. Additionally, GP showed no side effects such as weight loss in body weight and internal organs (lung, liver, kidney, and heart) as well as inactivity during the experiment. Therefore, GP might be conveniently exploited to be good immune-stimulating modifiers and had the potential value for tumor therapy. Ginseng polysaccharide (dpeaa)DE-He213 Antitumor (dpeaa)DE-He213 Immunomodulatory (dpeaa)DE-He213 Shi, Huaiyin aut Jiang, Gening aut Zhou, Yongan aut Xu, Jianfang aut Enthalten in Tumor biology Amsterdam : IOS Press, 1987 35(2014), 12 vom: 11. Sept., Seite 12561-12566 (DE-627)300897855 (DE-600)1483579-4 1423-0380 nnns volume:35 year:2014 number:12 day:11 month:09 pages:12561-12566 https://dx.doi.org/10.1007/s13277-014-2576-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_22 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_63 GBV_ILN_95 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_187 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_370 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4338 AR 35 2014 12 11 09 12561-12566
allfields_unstemmed	10.1007/s13277-014-2576-7 doi (DE-627)SPR03113694X (SPR)s13277-014-2576-7-e DE-627 ger DE-627 rakwb eng Zhou, Xiao verfasserin aut Antitumor activities of ginseng polysaccharide in C57BL/6 mice with Lewis lung carcinoma 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © International Society of Oncology and BioMarkers (ISOBM) 2014 Abstract In the present study, we prepared ginseng polysaccharide (GP) and evaluated its antitumor and immunomodulatory activities in C57BL/6 mice bearing with Lewis lung carcinoma (LLC). Administration of GP (50, 100, and 200 mg/kg) could not only significantly inhibit the growth of transplantable LLC tumor in C57BL/6 mice but also remarkably increase relative weight of spleen and thymus, splenocytes proliferation, and the ratio of $ CD4^{+} $/$ CD8^{+} $ T lymphocyte in peripheral blood in LLC-bearing mice. Furthermore, the serum IL-2 and IFN-γ production and NK cytolytic activity were also prompted in LLC-bearing mice in response to GP treatment at three doses. Additionally, GP showed no side effects such as weight loss in body weight and internal organs (lung, liver, kidney, and heart) as well as inactivity during the experiment. Therefore, GP might be conveniently exploited to be good immune-stimulating modifiers and had the potential value for tumor therapy. Ginseng polysaccharide (dpeaa)DE-He213 Antitumor (dpeaa)DE-He213 Immunomodulatory (dpeaa)DE-He213 Shi, Huaiyin aut Jiang, Gening aut Zhou, Yongan aut Xu, Jianfang aut Enthalten in Tumor biology Amsterdam : IOS Press, 1987 35(2014), 12 vom: 11. Sept., Seite 12561-12566 (DE-627)300897855 (DE-600)1483579-4 1423-0380 nnns volume:35 year:2014 number:12 day:11 month:09 pages:12561-12566 https://dx.doi.org/10.1007/s13277-014-2576-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_22 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_63 GBV_ILN_95 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_187 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_370 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4338 AR 35 2014 12 11 09 12561-12566
allfieldsGer	10.1007/s13277-014-2576-7 doi (DE-627)SPR03113694X (SPR)s13277-014-2576-7-e DE-627 ger DE-627 rakwb eng Zhou, Xiao verfasserin aut Antitumor activities of ginseng polysaccharide in C57BL/6 mice with Lewis lung carcinoma 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © International Society of Oncology and BioMarkers (ISOBM) 2014 Abstract In the present study, we prepared ginseng polysaccharide (GP) and evaluated its antitumor and immunomodulatory activities in C57BL/6 mice bearing with Lewis lung carcinoma (LLC). Administration of GP (50, 100, and 200 mg/kg) could not only significantly inhibit the growth of transplantable LLC tumor in C57BL/6 mice but also remarkably increase relative weight of spleen and thymus, splenocytes proliferation, and the ratio of $ CD4^{+} $/$ CD8^{+} $ T lymphocyte in peripheral blood in LLC-bearing mice. Furthermore, the serum IL-2 and IFN-γ production and NK cytolytic activity were also prompted in LLC-bearing mice in response to GP treatment at three doses. Additionally, GP showed no side effects such as weight loss in body weight and internal organs (lung, liver, kidney, and heart) as well as inactivity during the experiment. Therefore, GP might be conveniently exploited to be good immune-stimulating modifiers and had the potential value for tumor therapy. Ginseng polysaccharide (dpeaa)DE-He213 Antitumor (dpeaa)DE-He213 Immunomodulatory (dpeaa)DE-He213 Shi, Huaiyin aut Jiang, Gening aut Zhou, Yongan aut Xu, Jianfang aut Enthalten in Tumor biology Amsterdam : IOS Press, 1987 35(2014), 12 vom: 11. Sept., Seite 12561-12566 (DE-627)300897855 (DE-600)1483579-4 1423-0380 nnns volume:35 year:2014 number:12 day:11 month:09 pages:12561-12566 https://dx.doi.org/10.1007/s13277-014-2576-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_22 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_63 GBV_ILN_95 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_187 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_370 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4338 AR 35 2014 12 11 09 12561-12566
allfieldsSound	10.1007/s13277-014-2576-7 doi (DE-627)SPR03113694X (SPR)s13277-014-2576-7-e DE-627 ger DE-627 rakwb eng Zhou, Xiao verfasserin aut Antitumor activities of ginseng polysaccharide in C57BL/6 mice with Lewis lung carcinoma 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © International Society of Oncology and BioMarkers (ISOBM) 2014 Abstract In the present study, we prepared ginseng polysaccharide (GP) and evaluated its antitumor and immunomodulatory activities in C57BL/6 mice bearing with Lewis lung carcinoma (LLC). Administration of GP (50, 100, and 200 mg/kg) could not only significantly inhibit the growth of transplantable LLC tumor in C57BL/6 mice but also remarkably increase relative weight of spleen and thymus, splenocytes proliferation, and the ratio of $ CD4^{+} $/$ CD8^{+} $ T lymphocyte in peripheral blood in LLC-bearing mice. Furthermore, the serum IL-2 and IFN-γ production and NK cytolytic activity were also prompted in LLC-bearing mice in response to GP treatment at three doses. Additionally, GP showed no side effects such as weight loss in body weight and internal organs (lung, liver, kidney, and heart) as well as inactivity during the experiment. Therefore, GP might be conveniently exploited to be good immune-stimulating modifiers and had the potential value for tumor therapy. Ginseng polysaccharide (dpeaa)DE-He213 Antitumor (dpeaa)DE-He213 Immunomodulatory (dpeaa)DE-He213 Shi, Huaiyin aut Jiang, Gening aut Zhou, Yongan aut Xu, Jianfang aut Enthalten in Tumor biology Amsterdam : IOS Press, 1987 35(2014), 12 vom: 11. Sept., Seite 12561-12566 (DE-627)300897855 (DE-600)1483579-4 1423-0380 nnns volume:35 year:2014 number:12 day:11 month:09 pages:12561-12566 https://dx.doi.org/10.1007/s13277-014-2576-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_22 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_63 GBV_ILN_95 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_187 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_370 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4338 AR 35 2014 12 11 09 12561-12566
language	English
source	Enthalten in Tumor biology 35(2014), 12 vom: 11. Sept., Seite 12561-12566 volume:35 year:2014 number:12 day:11 month:09 pages:12561-12566
sourceStr	Enthalten in Tumor biology 35(2014), 12 vom: 11. Sept., Seite 12561-12566 volume:35 year:2014 number:12 day:11 month:09 pages:12561-12566
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Ginseng polysaccharide Antitumor Immunomodulatory
isfreeaccess_bool	false
container_title	Tumor biology
authorswithroles_txt_mv	Zhou, Xiao @@aut@@ Shi, Huaiyin @@aut@@ Jiang, Gening @@aut@@ Zhou, Yongan @@aut@@ Xu, Jianfang @@aut@@
publishDateDaySort_date	2014-09-11T00:00:00Z
hierarchy_top_id	300897855
id	SPR03113694X
language_de	englisch
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author	Zhou, Xiao
spellingShingle	Zhou, Xiao misc Ginseng polysaccharide misc Antitumor misc Immunomodulatory Antitumor activities of ginseng polysaccharide in C57BL/6 mice with Lewis lung carcinoma
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topic_title	Antitumor activities of ginseng polysaccharide in C57BL/6 mice with Lewis lung carcinoma Ginseng polysaccharide (dpeaa)DE-He213 Antitumor (dpeaa)DE-He213 Immunomodulatory (dpeaa)DE-He213
topic	misc Ginseng polysaccharide misc Antitumor misc Immunomodulatory
topic_unstemmed	misc Ginseng polysaccharide misc Antitumor misc Immunomodulatory
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title	Antitumor activities of ginseng polysaccharide in C57BL/6 mice with Lewis lung carcinoma
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title_full	Antitumor activities of ginseng polysaccharide in C57BL/6 mice with Lewis lung carcinoma
author_sort	Zhou, Xiao
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author_browse	Zhou, Xiao Shi, Huaiyin Jiang, Gening Zhou, Yongan Xu, Jianfang
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author-letter	Zhou, Xiao
doi_str_mv	10.1007/s13277-014-2576-7
title_sort	antitumor activities of ginseng polysaccharide in c57bl/6 mice with lewis lung carcinoma
title_auth	Antitumor activities of ginseng polysaccharide in C57BL/6 mice with Lewis lung carcinoma
abstract	Abstract In the present study, we prepared ginseng polysaccharide (GP) and evaluated its antitumor and immunomodulatory activities in C57BL/6 mice bearing with Lewis lung carcinoma (LLC). Administration of GP (50, 100, and 200 mg/kg) could not only significantly inhibit the growth of transplantable LLC tumor in C57BL/6 mice but also remarkably increase relative weight of spleen and thymus, splenocytes proliferation, and the ratio of $ CD4^{+} $/$ CD8^{+} $ T lymphocyte in peripheral blood in LLC-bearing mice. Furthermore, the serum IL-2 and IFN-γ production and NK cytolytic activity were also prompted in LLC-bearing mice in response to GP treatment at three doses. Additionally, GP showed no side effects such as weight loss in body weight and internal organs (lung, liver, kidney, and heart) as well as inactivity during the experiment. Therefore, GP might be conveniently exploited to be good immune-stimulating modifiers and had the potential value for tumor therapy. © International Society of Oncology and BioMarkers (ISOBM) 2014
abstractGer	Abstract In the present study, we prepared ginseng polysaccharide (GP) and evaluated its antitumor and immunomodulatory activities in C57BL/6 mice bearing with Lewis lung carcinoma (LLC). Administration of GP (50, 100, and 200 mg/kg) could not only significantly inhibit the growth of transplantable LLC tumor in C57BL/6 mice but also remarkably increase relative weight of spleen and thymus, splenocytes proliferation, and the ratio of $ CD4^{+} $/$ CD8^{+} $ T lymphocyte in peripheral blood in LLC-bearing mice. Furthermore, the serum IL-2 and IFN-γ production and NK cytolytic activity were also prompted in LLC-bearing mice in response to GP treatment at three doses. Additionally, GP showed no side effects such as weight loss in body weight and internal organs (lung, liver, kidney, and heart) as well as inactivity during the experiment. Therefore, GP might be conveniently exploited to be good immune-stimulating modifiers and had the potential value for tumor therapy. © International Society of Oncology and BioMarkers (ISOBM) 2014
abstract_unstemmed	Abstract In the present study, we prepared ginseng polysaccharide (GP) and evaluated its antitumor and immunomodulatory activities in C57BL/6 mice bearing with Lewis lung carcinoma (LLC). Administration of GP (50, 100, and 200 mg/kg) could not only significantly inhibit the growth of transplantable LLC tumor in C57BL/6 mice but also remarkably increase relative weight of spleen and thymus, splenocytes proliferation, and the ratio of $ CD4^{+} $/$ CD8^{+} $ T lymphocyte in peripheral blood in LLC-bearing mice. Furthermore, the serum IL-2 and IFN-γ production and NK cytolytic activity were also prompted in LLC-bearing mice in response to GP treatment at three doses. Additionally, GP showed no side effects such as weight loss in body weight and internal organs (lung, liver, kidney, and heart) as well as inactivity during the experiment. Therefore, GP might be conveniently exploited to be good immune-stimulating modifiers and had the potential value for tumor therapy. © International Society of Oncology and BioMarkers (ISOBM) 2014
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title_short	Antitumor activities of ginseng polysaccharide in C57BL/6 mice with Lewis lung carcinoma
url	https://dx.doi.org/10.1007/s13277-014-2576-7
remote_bool	true
author2	Shi, Huaiyin Jiang, Gening Zhou, Yongan Xu, Jianfang
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up_date	2024-07-03T22:11:37.264Z
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