Hematopoietic cell differentiation from embryonic and induced pluripotent stem cells

Abstract Pluripotent stem cells, both embryonic stem cells and induced pluripotent stem cells, are undifferentiated cells that can self-renew and potentially differentiate into all hematopoietic lineages, such as hematopoietic stem cells (HSCs), hematopoietic progenitor cells and mature hematopoieti...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Lim, Wai Feng [verfasserIn] Inoue-Yokoo, Tomoko Tan, Keai Sinn Lai, Mei I Sugiyama, Daisuke

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	Embryonic Stem Cell Stem Cell Factor Human Embryonic Stem Cell Mouse Embryonic Stem Cell Hematopoietic Lineage

Anmerkung:	© BioMed Central Ltd. 2013

Übergeordnetes Werk:	Enthalten in: Stem cell research & therapy - London : BioMed Central, 2010, 4(2013), 3 vom: 18. Juni
Übergeordnetes Werk:	volume:4 ; year:2013 ; number:3 ; day:18 ; month:06

Links:	Volltext

DOI / URN:	10.1186/scrt222

Katalog-ID:	SPR031210910

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520			\|a Abstract Pluripotent stem cells, both embryonic stem cells and induced pluripotent stem cells, are undifferentiated cells that can self-renew and potentially differentiate into all hematopoietic lineages, such as hematopoietic stem cells (HSCs), hematopoietic progenitor cells and mature hematopoietic cells in the presence of a suitable culture system. Establishment of pluripotent stem cells provides a comprehensive model to study early hematopoietic development and has emerged as a powerful research tool to explore regenerative medicine. Nowadays, HSC transplantation and hematopoietic cell transfusion have successfully cured some patients, especially in malignant hematological diseases. Owing to a shortage of donors and a limited number of the cells, hematopoietic cell induction from pluripotent stem cells has been regarded as an alternative source of HSCs and mature hematopoietic cells for intended therapeutic purposes. Pluripotent stem cells are therefore extensively utilized to facilitate better understanding in hematopoietic development by recapitulating embryonic development in vivo, in which efficient strategies can be easily designed and deployed for the generation of hematopoietic lineages in vitro. We hereby review the current progress of hematopoietic cell induction from embryonic stem/induced pluripotent stem cells.
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allfields	10.1186/scrt222 doi (DE-627)SPR031210910 (SPR)scrt222-e DE-627 ger DE-627 rakwb eng Lim, Wai Feng verfasserin aut Hematopoietic cell differentiation from embryonic and induced pluripotent stem cells 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd. 2013 Abstract Pluripotent stem cells, both embryonic stem cells and induced pluripotent stem cells, are undifferentiated cells that can self-renew and potentially differentiate into all hematopoietic lineages, such as hematopoietic stem cells (HSCs), hematopoietic progenitor cells and mature hematopoietic cells in the presence of a suitable culture system. Establishment of pluripotent stem cells provides a comprehensive model to study early hematopoietic development and has emerged as a powerful research tool to explore regenerative medicine. Nowadays, HSC transplantation and hematopoietic cell transfusion have successfully cured some patients, especially in malignant hematological diseases. Owing to a shortage of donors and a limited number of the cells, hematopoietic cell induction from pluripotent stem cells has been regarded as an alternative source of HSCs and mature hematopoietic cells for intended therapeutic purposes. Pluripotent stem cells are therefore extensively utilized to facilitate better understanding in hematopoietic development by recapitulating embryonic development in vivo, in which efficient strategies can be easily designed and deployed for the generation of hematopoietic lineages in vitro. We hereby review the current progress of hematopoietic cell induction from embryonic stem/induced pluripotent stem cells. Embryonic Stem Cell (dpeaa)DE-He213 Stem Cell Factor (dpeaa)DE-He213 Human Embryonic Stem Cell (dpeaa)DE-He213 Mouse Embryonic Stem Cell (dpeaa)DE-He213 Hematopoietic Lineage (dpeaa)DE-He213 Inoue-Yokoo, Tomoko aut Tan, Keai Sinn aut Lai, Mei I aut Sugiyama, Daisuke aut Enthalten in Stem cell research & therapy London : BioMed Central, 2010 4(2013), 3 vom: 18. Juni (DE-627)624251047 (DE-600)2548671-8 1757-6512 nnns volume:4 year:2013 number:3 day:18 month:06 https://dx.doi.org/10.1186/scrt222 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2013 3 18 06
spelling	10.1186/scrt222 doi (DE-627)SPR031210910 (SPR)scrt222-e DE-627 ger DE-627 rakwb eng Lim, Wai Feng verfasserin aut Hematopoietic cell differentiation from embryonic and induced pluripotent stem cells 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd. 2013 Abstract Pluripotent stem cells, both embryonic stem cells and induced pluripotent stem cells, are undifferentiated cells that can self-renew and potentially differentiate into all hematopoietic lineages, such as hematopoietic stem cells (HSCs), hematopoietic progenitor cells and mature hematopoietic cells in the presence of a suitable culture system. Establishment of pluripotent stem cells provides a comprehensive model to study early hematopoietic development and has emerged as a powerful research tool to explore regenerative medicine. Nowadays, HSC transplantation and hematopoietic cell transfusion have successfully cured some patients, especially in malignant hematological diseases. Owing to a shortage of donors and a limited number of the cells, hematopoietic cell induction from pluripotent stem cells has been regarded as an alternative source of HSCs and mature hematopoietic cells for intended therapeutic purposes. Pluripotent stem cells are therefore extensively utilized to facilitate better understanding in hematopoietic development by recapitulating embryonic development in vivo, in which efficient strategies can be easily designed and deployed for the generation of hematopoietic lineages in vitro. We hereby review the current progress of hematopoietic cell induction from embryonic stem/induced pluripotent stem cells. Embryonic Stem Cell (dpeaa)DE-He213 Stem Cell Factor (dpeaa)DE-He213 Human Embryonic Stem Cell (dpeaa)DE-He213 Mouse Embryonic Stem Cell (dpeaa)DE-He213 Hematopoietic Lineage (dpeaa)DE-He213 Inoue-Yokoo, Tomoko aut Tan, Keai Sinn aut Lai, Mei I aut Sugiyama, Daisuke aut Enthalten in Stem cell research & therapy London : BioMed Central, 2010 4(2013), 3 vom: 18. Juni (DE-627)624251047 (DE-600)2548671-8 1757-6512 nnns volume:4 year:2013 number:3 day:18 month:06 https://dx.doi.org/10.1186/scrt222 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2013 3 18 06
allfields_unstemmed	10.1186/scrt222 doi (DE-627)SPR031210910 (SPR)scrt222-e DE-627 ger DE-627 rakwb eng Lim, Wai Feng verfasserin aut Hematopoietic cell differentiation from embryonic and induced pluripotent stem cells 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd. 2013 Abstract Pluripotent stem cells, both embryonic stem cells and induced pluripotent stem cells, are undifferentiated cells that can self-renew and potentially differentiate into all hematopoietic lineages, such as hematopoietic stem cells (HSCs), hematopoietic progenitor cells and mature hematopoietic cells in the presence of a suitable culture system. Establishment of pluripotent stem cells provides a comprehensive model to study early hematopoietic development and has emerged as a powerful research tool to explore regenerative medicine. Nowadays, HSC transplantation and hematopoietic cell transfusion have successfully cured some patients, especially in malignant hematological diseases. Owing to a shortage of donors and a limited number of the cells, hematopoietic cell induction from pluripotent stem cells has been regarded as an alternative source of HSCs and mature hematopoietic cells for intended therapeutic purposes. Pluripotent stem cells are therefore extensively utilized to facilitate better understanding in hematopoietic development by recapitulating embryonic development in vivo, in which efficient strategies can be easily designed and deployed for the generation of hematopoietic lineages in vitro. We hereby review the current progress of hematopoietic cell induction from embryonic stem/induced pluripotent stem cells. Embryonic Stem Cell (dpeaa)DE-He213 Stem Cell Factor (dpeaa)DE-He213 Human Embryonic Stem Cell (dpeaa)DE-He213 Mouse Embryonic Stem Cell (dpeaa)DE-He213 Hematopoietic Lineage (dpeaa)DE-He213 Inoue-Yokoo, Tomoko aut Tan, Keai Sinn aut Lai, Mei I aut Sugiyama, Daisuke aut Enthalten in Stem cell research & therapy London : BioMed Central, 2010 4(2013), 3 vom: 18. Juni (DE-627)624251047 (DE-600)2548671-8 1757-6512 nnns volume:4 year:2013 number:3 day:18 month:06 https://dx.doi.org/10.1186/scrt222 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2013 3 18 06
allfieldsGer	10.1186/scrt222 doi (DE-627)SPR031210910 (SPR)scrt222-e DE-627 ger DE-627 rakwb eng Lim, Wai Feng verfasserin aut Hematopoietic cell differentiation from embryonic and induced pluripotent stem cells 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd. 2013 Abstract Pluripotent stem cells, both embryonic stem cells and induced pluripotent stem cells, are undifferentiated cells that can self-renew and potentially differentiate into all hematopoietic lineages, such as hematopoietic stem cells (HSCs), hematopoietic progenitor cells and mature hematopoietic cells in the presence of a suitable culture system. Establishment of pluripotent stem cells provides a comprehensive model to study early hematopoietic development and has emerged as a powerful research tool to explore regenerative medicine. Nowadays, HSC transplantation and hematopoietic cell transfusion have successfully cured some patients, especially in malignant hematological diseases. Owing to a shortage of donors and a limited number of the cells, hematopoietic cell induction from pluripotent stem cells has been regarded as an alternative source of HSCs and mature hematopoietic cells for intended therapeutic purposes. Pluripotent stem cells are therefore extensively utilized to facilitate better understanding in hematopoietic development by recapitulating embryonic development in vivo, in which efficient strategies can be easily designed and deployed for the generation of hematopoietic lineages in vitro. We hereby review the current progress of hematopoietic cell induction from embryonic stem/induced pluripotent stem cells. Embryonic Stem Cell (dpeaa)DE-He213 Stem Cell Factor (dpeaa)DE-He213 Human Embryonic Stem Cell (dpeaa)DE-He213 Mouse Embryonic Stem Cell (dpeaa)DE-He213 Hematopoietic Lineage (dpeaa)DE-He213 Inoue-Yokoo, Tomoko aut Tan, Keai Sinn aut Lai, Mei I aut Sugiyama, Daisuke aut Enthalten in Stem cell research & therapy London : BioMed Central, 2010 4(2013), 3 vom: 18. Juni (DE-627)624251047 (DE-600)2548671-8 1757-6512 nnns volume:4 year:2013 number:3 day:18 month:06 https://dx.doi.org/10.1186/scrt222 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2013 3 18 06
allfieldsSound	10.1186/scrt222 doi (DE-627)SPR031210910 (SPR)scrt222-e DE-627 ger DE-627 rakwb eng Lim, Wai Feng verfasserin aut Hematopoietic cell differentiation from embryonic and induced pluripotent stem cells 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd. 2013 Abstract Pluripotent stem cells, both embryonic stem cells and induced pluripotent stem cells, are undifferentiated cells that can self-renew and potentially differentiate into all hematopoietic lineages, such as hematopoietic stem cells (HSCs), hematopoietic progenitor cells and mature hematopoietic cells in the presence of a suitable culture system. Establishment of pluripotent stem cells provides a comprehensive model to study early hematopoietic development and has emerged as a powerful research tool to explore regenerative medicine. Nowadays, HSC transplantation and hematopoietic cell transfusion have successfully cured some patients, especially in malignant hematological diseases. Owing to a shortage of donors and a limited number of the cells, hematopoietic cell induction from pluripotent stem cells has been regarded as an alternative source of HSCs and mature hematopoietic cells for intended therapeutic purposes. Pluripotent stem cells are therefore extensively utilized to facilitate better understanding in hematopoietic development by recapitulating embryonic development in vivo, in which efficient strategies can be easily designed and deployed for the generation of hematopoietic lineages in vitro. We hereby review the current progress of hematopoietic cell induction from embryonic stem/induced pluripotent stem cells. Embryonic Stem Cell (dpeaa)DE-He213 Stem Cell Factor (dpeaa)DE-He213 Human Embryonic Stem Cell (dpeaa)DE-He213 Mouse Embryonic Stem Cell (dpeaa)DE-He213 Hematopoietic Lineage (dpeaa)DE-He213 Inoue-Yokoo, Tomoko aut Tan, Keai Sinn aut Lai, Mei I aut Sugiyama, Daisuke aut Enthalten in Stem cell research & therapy London : BioMed Central, 2010 4(2013), 3 vom: 18. Juni (DE-627)624251047 (DE-600)2548671-8 1757-6512 nnns volume:4 year:2013 number:3 day:18 month:06 https://dx.doi.org/10.1186/scrt222 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2013 3 18 06
language	English
source	Enthalten in Stem cell research & therapy 4(2013), 3 vom: 18. Juni volume:4 year:2013 number:3 day:18 month:06
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topic_facet	Embryonic Stem Cell Stem Cell Factor Human Embryonic Stem Cell Mouse Embryonic Stem Cell Hematopoietic Lineage
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container_title	Stem cell research & therapy
authorswithroles_txt_mv	Lim, Wai Feng @@aut@@ Inoue-Yokoo, Tomoko @@aut@@ Tan, Keai Sinn @@aut@@ Lai, Mei I @@aut@@ Sugiyama, Daisuke @@aut@@
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author	Lim, Wai Feng
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topic_title	Hematopoietic cell differentiation from embryonic and induced pluripotent stem cells Embryonic Stem Cell (dpeaa)DE-He213 Stem Cell Factor (dpeaa)DE-He213 Human Embryonic Stem Cell (dpeaa)DE-He213 Mouse Embryonic Stem Cell (dpeaa)DE-He213 Hematopoietic Lineage (dpeaa)DE-He213
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title	Hematopoietic cell differentiation from embryonic and induced pluripotent stem cells
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title_full	Hematopoietic cell differentiation from embryonic and induced pluripotent stem cells
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title_sort	hematopoietic cell differentiation from embryonic and induced pluripotent stem cells
title_auth	Hematopoietic cell differentiation from embryonic and induced pluripotent stem cells
abstract	Abstract Pluripotent stem cells, both embryonic stem cells and induced pluripotent stem cells, are undifferentiated cells that can self-renew and potentially differentiate into all hematopoietic lineages, such as hematopoietic stem cells (HSCs), hematopoietic progenitor cells and mature hematopoietic cells in the presence of a suitable culture system. Establishment of pluripotent stem cells provides a comprehensive model to study early hematopoietic development and has emerged as a powerful research tool to explore regenerative medicine. Nowadays, HSC transplantation and hematopoietic cell transfusion have successfully cured some patients, especially in malignant hematological diseases. Owing to a shortage of donors and a limited number of the cells, hematopoietic cell induction from pluripotent stem cells has been regarded as an alternative source of HSCs and mature hematopoietic cells for intended therapeutic purposes. Pluripotent stem cells are therefore extensively utilized to facilitate better understanding in hematopoietic development by recapitulating embryonic development in vivo, in which efficient strategies can be easily designed and deployed for the generation of hematopoietic lineages in vitro. We hereby review the current progress of hematopoietic cell induction from embryonic stem/induced pluripotent stem cells. © BioMed Central Ltd. 2013
abstractGer	Abstract Pluripotent stem cells, both embryonic stem cells and induced pluripotent stem cells, are undifferentiated cells that can self-renew and potentially differentiate into all hematopoietic lineages, such as hematopoietic stem cells (HSCs), hematopoietic progenitor cells and mature hematopoietic cells in the presence of a suitable culture system. Establishment of pluripotent stem cells provides a comprehensive model to study early hematopoietic development and has emerged as a powerful research tool to explore regenerative medicine. Nowadays, HSC transplantation and hematopoietic cell transfusion have successfully cured some patients, especially in malignant hematological diseases. Owing to a shortage of donors and a limited number of the cells, hematopoietic cell induction from pluripotent stem cells has been regarded as an alternative source of HSCs and mature hematopoietic cells for intended therapeutic purposes. Pluripotent stem cells are therefore extensively utilized to facilitate better understanding in hematopoietic development by recapitulating embryonic development in vivo, in which efficient strategies can be easily designed and deployed for the generation of hematopoietic lineages in vitro. We hereby review the current progress of hematopoietic cell induction from embryonic stem/induced pluripotent stem cells. © BioMed Central Ltd. 2013
abstract_unstemmed	Abstract Pluripotent stem cells, both embryonic stem cells and induced pluripotent stem cells, are undifferentiated cells that can self-renew and potentially differentiate into all hematopoietic lineages, such as hematopoietic stem cells (HSCs), hematopoietic progenitor cells and mature hematopoietic cells in the presence of a suitable culture system. Establishment of pluripotent stem cells provides a comprehensive model to study early hematopoietic development and has emerged as a powerful research tool to explore regenerative medicine. Nowadays, HSC transplantation and hematopoietic cell transfusion have successfully cured some patients, especially in malignant hematological diseases. Owing to a shortage of donors and a limited number of the cells, hematopoietic cell induction from pluripotent stem cells has been regarded as an alternative source of HSCs and mature hematopoietic cells for intended therapeutic purposes. Pluripotent stem cells are therefore extensively utilized to facilitate better understanding in hematopoietic development by recapitulating embryonic development in vivo, in which efficient strategies can be easily designed and deployed for the generation of hematopoietic lineages in vitro. We hereby review the current progress of hematopoietic cell induction from embryonic stem/induced pluripotent stem cells. © BioMed Central Ltd. 2013
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title_short	Hematopoietic cell differentiation from embryonic and induced pluripotent stem cells
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Hematopoietic cell differentiation from embryonic and induced pluripotent stem cells

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