The cell cycle as a brake for β-cell regeneration from embryonic stem cells

Abstract The generation of insulin-producing β cells from stem cells in vitro provides a promising source of cells for cell transplantation therapy in diabetes. However, insulin-producing cells generated from human stem cells show deficiency in many functional characteristics compared with pancreati...
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Gespeichert in:

Autor*in:	El-Badawy, Ahmed [verfasserIn] El-Badri, Nagwa

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Embryonic Stem Cell CDK2 Activity Cell Fate Decision Cell Cycle Machinery Pancreatic Progenitor Cell

Anmerkung:	© El-Badawy and El-Badri. 2016

Übergeordnetes Werk:	Enthalten in: Stem cell research & therapy - London : BioMed Central, 2010, 7(2016), 1 vom: 13. Jan.
Übergeordnetes Werk:	volume:7 ; year:2016 ; number:1 ; day:13 ; month:01

Links:	Volltext

DOI / URN:	10.1186/s13287-015-0274-z

Katalog-ID:	SPR031216919

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allfields	10.1186/s13287-015-0274-z doi (DE-627)SPR031216919 (SPR)s13287-015-0274-z-e DE-627 ger DE-627 rakwb eng El-Badawy, Ahmed verfasserin aut The cell cycle as a brake for β-cell regeneration from embryonic stem cells 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © El-Badawy and El-Badri. 2016 Abstract The generation of insulin-producing β cells from stem cells in vitro provides a promising source of cells for cell transplantation therapy in diabetes. However, insulin-producing cells generated from human stem cells show deficiency in many functional characteristics compared with pancreatic β cells. Recent reports have shown molecular ties between the cell cycle and the differentiation mechanism of embryonic stem (ES) cells, assuming that cell fate decisions are controlled by the cell cycle machinery. Both β cells and ES cells possess unique cell cycle machinery yet with significant contrasts. In this review, we compare the cell cycle control mechanisms in both ES cells and β cells, and highlight the fundamental differences between pluripotent cells of embryonic origin and differentiated β cells. Through critical analysis of the differences of the cell cycle between these two cell types, we propose that the cell cycle of ES cells may act as a brake for β-cell regeneration. Based on these differences, we discuss the potential of modulating the cell cycle of ES cells for the large-scale generation of functionally mature β cells in vitro. Further understanding of the factors that modulate the ES cell cycle will lead to new approaches to enhance the production of functional mature insulin-producing cells, and yield a reliable system to generate bona fide β cells in vitro. Embryonic Stem Cell (dpeaa)DE-He213 CDK2 Activity (dpeaa)DE-He213 Cell Fate Decision (dpeaa)DE-He213 Cell Cycle Machinery (dpeaa)DE-He213 Pancreatic Progenitor Cell (dpeaa)DE-He213 El-Badri, Nagwa aut Enthalten in Stem cell research & therapy London : BioMed Central, 2010 7(2016), 1 vom: 13. Jan. (DE-627)624251047 (DE-600)2548671-8 1757-6512 nnns volume:7 year:2016 number:1 day:13 month:01 https://dx.doi.org/10.1186/s13287-015-0274-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2016 1 13 01
spelling	10.1186/s13287-015-0274-z doi (DE-627)SPR031216919 (SPR)s13287-015-0274-z-e DE-627 ger DE-627 rakwb eng El-Badawy, Ahmed verfasserin aut The cell cycle as a brake for β-cell regeneration from embryonic stem cells 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © El-Badawy and El-Badri. 2016 Abstract The generation of insulin-producing β cells from stem cells in vitro provides a promising source of cells for cell transplantation therapy in diabetes. However, insulin-producing cells generated from human stem cells show deficiency in many functional characteristics compared with pancreatic β cells. Recent reports have shown molecular ties between the cell cycle and the differentiation mechanism of embryonic stem (ES) cells, assuming that cell fate decisions are controlled by the cell cycle machinery. Both β cells and ES cells possess unique cell cycle machinery yet with significant contrasts. In this review, we compare the cell cycle control mechanisms in both ES cells and β cells, and highlight the fundamental differences between pluripotent cells of embryonic origin and differentiated β cells. Through critical analysis of the differences of the cell cycle between these two cell types, we propose that the cell cycle of ES cells may act as a brake for β-cell regeneration. Based on these differences, we discuss the potential of modulating the cell cycle of ES cells for the large-scale generation of functionally mature β cells in vitro. Further understanding of the factors that modulate the ES cell cycle will lead to new approaches to enhance the production of functional mature insulin-producing cells, and yield a reliable system to generate bona fide β cells in vitro. Embryonic Stem Cell (dpeaa)DE-He213 CDK2 Activity (dpeaa)DE-He213 Cell Fate Decision (dpeaa)DE-He213 Cell Cycle Machinery (dpeaa)DE-He213 Pancreatic Progenitor Cell (dpeaa)DE-He213 El-Badri, Nagwa aut Enthalten in Stem cell research & therapy London : BioMed Central, 2010 7(2016), 1 vom: 13. Jan. (DE-627)624251047 (DE-600)2548671-8 1757-6512 nnns volume:7 year:2016 number:1 day:13 month:01 https://dx.doi.org/10.1186/s13287-015-0274-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2016 1 13 01
allfields_unstemmed	10.1186/s13287-015-0274-z doi (DE-627)SPR031216919 (SPR)s13287-015-0274-z-e DE-627 ger DE-627 rakwb eng El-Badawy, Ahmed verfasserin aut The cell cycle as a brake for β-cell regeneration from embryonic stem cells 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © El-Badawy and El-Badri. 2016 Abstract The generation of insulin-producing β cells from stem cells in vitro provides a promising source of cells for cell transplantation therapy in diabetes. However, insulin-producing cells generated from human stem cells show deficiency in many functional characteristics compared with pancreatic β cells. Recent reports have shown molecular ties between the cell cycle and the differentiation mechanism of embryonic stem (ES) cells, assuming that cell fate decisions are controlled by the cell cycle machinery. Both β cells and ES cells possess unique cell cycle machinery yet with significant contrasts. In this review, we compare the cell cycle control mechanisms in both ES cells and β cells, and highlight the fundamental differences between pluripotent cells of embryonic origin and differentiated β cells. Through critical analysis of the differences of the cell cycle between these two cell types, we propose that the cell cycle of ES cells may act as a brake for β-cell regeneration. Based on these differences, we discuss the potential of modulating the cell cycle of ES cells for the large-scale generation of functionally mature β cells in vitro. Further understanding of the factors that modulate the ES cell cycle will lead to new approaches to enhance the production of functional mature insulin-producing cells, and yield a reliable system to generate bona fide β cells in vitro. Embryonic Stem Cell (dpeaa)DE-He213 CDK2 Activity (dpeaa)DE-He213 Cell Fate Decision (dpeaa)DE-He213 Cell Cycle Machinery (dpeaa)DE-He213 Pancreatic Progenitor Cell (dpeaa)DE-He213 El-Badri, Nagwa aut Enthalten in Stem cell research & therapy London : BioMed Central, 2010 7(2016), 1 vom: 13. Jan. (DE-627)624251047 (DE-600)2548671-8 1757-6512 nnns volume:7 year:2016 number:1 day:13 month:01 https://dx.doi.org/10.1186/s13287-015-0274-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2016 1 13 01
allfieldsGer	10.1186/s13287-015-0274-z doi (DE-627)SPR031216919 (SPR)s13287-015-0274-z-e DE-627 ger DE-627 rakwb eng El-Badawy, Ahmed verfasserin aut The cell cycle as a brake for β-cell regeneration from embryonic stem cells 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © El-Badawy and El-Badri. 2016 Abstract The generation of insulin-producing β cells from stem cells in vitro provides a promising source of cells for cell transplantation therapy in diabetes. However, insulin-producing cells generated from human stem cells show deficiency in many functional characteristics compared with pancreatic β cells. Recent reports have shown molecular ties between the cell cycle and the differentiation mechanism of embryonic stem (ES) cells, assuming that cell fate decisions are controlled by the cell cycle machinery. Both β cells and ES cells possess unique cell cycle machinery yet with significant contrasts. In this review, we compare the cell cycle control mechanisms in both ES cells and β cells, and highlight the fundamental differences between pluripotent cells of embryonic origin and differentiated β cells. Through critical analysis of the differences of the cell cycle between these two cell types, we propose that the cell cycle of ES cells may act as a brake for β-cell regeneration. Based on these differences, we discuss the potential of modulating the cell cycle of ES cells for the large-scale generation of functionally mature β cells in vitro. Further understanding of the factors that modulate the ES cell cycle will lead to new approaches to enhance the production of functional mature insulin-producing cells, and yield a reliable system to generate bona fide β cells in vitro. Embryonic Stem Cell (dpeaa)DE-He213 CDK2 Activity (dpeaa)DE-He213 Cell Fate Decision (dpeaa)DE-He213 Cell Cycle Machinery (dpeaa)DE-He213 Pancreatic Progenitor Cell (dpeaa)DE-He213 El-Badri, Nagwa aut Enthalten in Stem cell research & therapy London : BioMed Central, 2010 7(2016), 1 vom: 13. Jan. (DE-627)624251047 (DE-600)2548671-8 1757-6512 nnns volume:7 year:2016 number:1 day:13 month:01 https://dx.doi.org/10.1186/s13287-015-0274-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2016 1 13 01
allfieldsSound	10.1186/s13287-015-0274-z doi (DE-627)SPR031216919 (SPR)s13287-015-0274-z-e DE-627 ger DE-627 rakwb eng El-Badawy, Ahmed verfasserin aut The cell cycle as a brake for β-cell regeneration from embryonic stem cells 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © El-Badawy and El-Badri. 2016 Abstract The generation of insulin-producing β cells from stem cells in vitro provides a promising source of cells for cell transplantation therapy in diabetes. However, insulin-producing cells generated from human stem cells show deficiency in many functional characteristics compared with pancreatic β cells. Recent reports have shown molecular ties between the cell cycle and the differentiation mechanism of embryonic stem (ES) cells, assuming that cell fate decisions are controlled by the cell cycle machinery. Both β cells and ES cells possess unique cell cycle machinery yet with significant contrasts. In this review, we compare the cell cycle control mechanisms in both ES cells and β cells, and highlight the fundamental differences between pluripotent cells of embryonic origin and differentiated β cells. Through critical analysis of the differences of the cell cycle between these two cell types, we propose that the cell cycle of ES cells may act as a brake for β-cell regeneration. Based on these differences, we discuss the potential of modulating the cell cycle of ES cells for the large-scale generation of functionally mature β cells in vitro. Further understanding of the factors that modulate the ES cell cycle will lead to new approaches to enhance the production of functional mature insulin-producing cells, and yield a reliable system to generate bona fide β cells in vitro. Embryonic Stem Cell (dpeaa)DE-He213 CDK2 Activity (dpeaa)DE-He213 Cell Fate Decision (dpeaa)DE-He213 Cell Cycle Machinery (dpeaa)DE-He213 Pancreatic Progenitor Cell (dpeaa)DE-He213 El-Badri, Nagwa aut Enthalten in Stem cell research & therapy London : BioMed Central, 2010 7(2016), 1 vom: 13. Jan. (DE-627)624251047 (DE-600)2548671-8 1757-6512 nnns volume:7 year:2016 number:1 day:13 month:01 https://dx.doi.org/10.1186/s13287-015-0274-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2016 1 13 01
language	English
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topic_facet	Embryonic Stem Cell CDK2 Activity Cell Fate Decision Cell Cycle Machinery Pancreatic Progenitor Cell
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container_title	Stem cell research & therapy
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author	El-Badawy, Ahmed
spellingShingle	El-Badawy, Ahmed misc Embryonic Stem Cell misc CDK2 Activity misc Cell Fate Decision misc Cell Cycle Machinery misc Pancreatic Progenitor Cell The cell cycle as a brake for β-cell regeneration from embryonic stem cells
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topic_title	The cell cycle as a brake for β-cell regeneration from embryonic stem cells Embryonic Stem Cell (dpeaa)DE-He213 CDK2 Activity (dpeaa)DE-He213 Cell Fate Decision (dpeaa)DE-He213 Cell Cycle Machinery (dpeaa)DE-He213 Pancreatic Progenitor Cell (dpeaa)DE-He213
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title	The cell cycle as a brake for β-cell regeneration from embryonic stem cells
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title_full	The cell cycle as a brake for β-cell regeneration from embryonic stem cells
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title_sort	cell cycle as a brake for β-cell regeneration from embryonic stem cells
title_auth	The cell cycle as a brake for β-cell regeneration from embryonic stem cells
abstract	Abstract The generation of insulin-producing β cells from stem cells in vitro provides a promising source of cells for cell transplantation therapy in diabetes. However, insulin-producing cells generated from human stem cells show deficiency in many functional characteristics compared with pancreatic β cells. Recent reports have shown molecular ties between the cell cycle and the differentiation mechanism of embryonic stem (ES) cells, assuming that cell fate decisions are controlled by the cell cycle machinery. Both β cells and ES cells possess unique cell cycle machinery yet with significant contrasts. In this review, we compare the cell cycle control mechanisms in both ES cells and β cells, and highlight the fundamental differences between pluripotent cells of embryonic origin and differentiated β cells. Through critical analysis of the differences of the cell cycle between these two cell types, we propose that the cell cycle of ES cells may act as a brake for β-cell regeneration. Based on these differences, we discuss the potential of modulating the cell cycle of ES cells for the large-scale generation of functionally mature β cells in vitro. Further understanding of the factors that modulate the ES cell cycle will lead to new approaches to enhance the production of functional mature insulin-producing cells, and yield a reliable system to generate bona fide β cells in vitro. © El-Badawy and El-Badri. 2016
abstractGer	Abstract The generation of insulin-producing β cells from stem cells in vitro provides a promising source of cells for cell transplantation therapy in diabetes. However, insulin-producing cells generated from human stem cells show deficiency in many functional characteristics compared with pancreatic β cells. Recent reports have shown molecular ties between the cell cycle and the differentiation mechanism of embryonic stem (ES) cells, assuming that cell fate decisions are controlled by the cell cycle machinery. Both β cells and ES cells possess unique cell cycle machinery yet with significant contrasts. In this review, we compare the cell cycle control mechanisms in both ES cells and β cells, and highlight the fundamental differences between pluripotent cells of embryonic origin and differentiated β cells. Through critical analysis of the differences of the cell cycle between these two cell types, we propose that the cell cycle of ES cells may act as a brake for β-cell regeneration. Based on these differences, we discuss the potential of modulating the cell cycle of ES cells for the large-scale generation of functionally mature β cells in vitro. Further understanding of the factors that modulate the ES cell cycle will lead to new approaches to enhance the production of functional mature insulin-producing cells, and yield a reliable system to generate bona fide β cells in vitro. © El-Badawy and El-Badri. 2016
abstract_unstemmed	Abstract The generation of insulin-producing β cells from stem cells in vitro provides a promising source of cells for cell transplantation therapy in diabetes. However, insulin-producing cells generated from human stem cells show deficiency in many functional characteristics compared with pancreatic β cells. Recent reports have shown molecular ties between the cell cycle and the differentiation mechanism of embryonic stem (ES) cells, assuming that cell fate decisions are controlled by the cell cycle machinery. Both β cells and ES cells possess unique cell cycle machinery yet with significant contrasts. In this review, we compare the cell cycle control mechanisms in both ES cells and β cells, and highlight the fundamental differences between pluripotent cells of embryonic origin and differentiated β cells. Through critical analysis of the differences of the cell cycle between these two cell types, we propose that the cell cycle of ES cells may act as a brake for β-cell regeneration. Based on these differences, we discuss the potential of modulating the cell cycle of ES cells for the large-scale generation of functionally mature β cells in vitro. Further understanding of the factors that modulate the ES cell cycle will lead to new approaches to enhance the production of functional mature insulin-producing cells, and yield a reliable system to generate bona fide β cells in vitro. © El-Badawy and El-Badri. 2016
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title_short	The cell cycle as a brake for β-cell regeneration from embryonic stem cells
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The cell cycle as a brake for β-cell regeneration from embryonic stem cells

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