Octanoic Acid Suppresses Harmaline-Induced Tremor in Mouse Model of Essential Tremor
Abstract Recent work exploring the use of high-molecular weight alcohols to treat essential tremor (ET) has identified octanoic acid as a potential novel tremor-suppressing agent. We used an established harmaline-based mouse model of ET to compare tremor suppression by 1-octanol and octanoic acid. T...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Nahab, Fatta B. [verfasserIn] |
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E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2012 |
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| Schlagwörter: |
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| Anmerkung: |
© The American Society for Experimental NeuroTherapeutics, Inc. (outside the U.S.) 2012 |
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| Übergeordnetes Werk: |
Enthalten in: NeuroRX - Springer-Verlag, 2006, 9(2012), 3 vom: 28. März, Seite 635-638 |
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| Übergeordnetes Werk: |
volume:9 ; year:2012 ; number:3 ; day:28 ; month:03 ; pages:635-638 |
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| DOI / URN: |
10.1007/s13311-012-0121-1 |
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| 520 | |a Abstract Recent work exploring the use of high-molecular weight alcohols to treat essential tremor (ET) has identified octanoic acid as a potential novel tremor-suppressing agent. We used an established harmaline-based mouse model of ET to compare tremor suppression by 1-octanol and octanoic acid. The dose-related effect on digitized motion power within the tremor bandwidth as a fraction of overall motion power was analyzed. Both 1-octanol and octanoic acid provided significant reductions in harmaline tremor. An 8-carbon alkyl alcohol and carboxylic acid each suppress tremor in a pre-clinical mouse model of ET. Further studies are warranted to determine the safety and efficacy of such agents in humans with ET. | ||
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10.1007/s13311-012-0121-1 doi (DE-627)SPR031267270 (SPR)s13311-012-0121-1-e DE-627 ger DE-627 rakwb eng Nahab, Fatta B. verfasserin aut Octanoic Acid Suppresses Harmaline-Induced Tremor in Mouse Model of Essential Tremor 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The American Society for Experimental NeuroTherapeutics, Inc. (outside the U.S.) 2012 Abstract Recent work exploring the use of high-molecular weight alcohols to treat essential tremor (ET) has identified octanoic acid as a potential novel tremor-suppressing agent. We used an established harmaline-based mouse model of ET to compare tremor suppression by 1-octanol and octanoic acid. The dose-related effect on digitized motion power within the tremor bandwidth as a fraction of overall motion power was analyzed. Both 1-octanol and octanoic acid provided significant reductions in harmaline tremor. An 8-carbon alkyl alcohol and carboxylic acid each suppress tremor in a pre-clinical mouse model of ET. Further studies are warranted to determine the safety and efficacy of such agents in humans with ET. 1-octanol (dpeaa)DE-He213 Octanoic acid (dpeaa)DE-He213 Essential tremor (dpeaa)DE-He213 Harmaline (dpeaa)DE-He213 Therapeutics (dpeaa)DE-He213 Handforth, Adrian aut Brown, Tyler aut Shin, Christopher aut Quesada, Arnulfo aut Dong, Chuanhui aut Haubenberger, Dietrich aut Hallett, Mark aut Enthalten in NeuroRX Springer-Verlag, 2006 9(2012), 3 vom: 28. März, Seite 635-638 (DE-627)SPR031264964 nnns volume:9 year:2012 number:3 day:28 month:03 pages:635-638 https://dx.doi.org/10.1007/s13311-012-0121-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 9 2012 3 28 03 635-638 |
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10.1007/s13311-012-0121-1 doi (DE-627)SPR031267270 (SPR)s13311-012-0121-1-e DE-627 ger DE-627 rakwb eng Nahab, Fatta B. verfasserin aut Octanoic Acid Suppresses Harmaline-Induced Tremor in Mouse Model of Essential Tremor 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The American Society for Experimental NeuroTherapeutics, Inc. (outside the U.S.) 2012 Abstract Recent work exploring the use of high-molecular weight alcohols to treat essential tremor (ET) has identified octanoic acid as a potential novel tremor-suppressing agent. We used an established harmaline-based mouse model of ET to compare tremor suppression by 1-octanol and octanoic acid. The dose-related effect on digitized motion power within the tremor bandwidth as a fraction of overall motion power was analyzed. Both 1-octanol and octanoic acid provided significant reductions in harmaline tremor. An 8-carbon alkyl alcohol and carboxylic acid each suppress tremor in a pre-clinical mouse model of ET. Further studies are warranted to determine the safety and efficacy of such agents in humans with ET. 1-octanol (dpeaa)DE-He213 Octanoic acid (dpeaa)DE-He213 Essential tremor (dpeaa)DE-He213 Harmaline (dpeaa)DE-He213 Therapeutics (dpeaa)DE-He213 Handforth, Adrian aut Brown, Tyler aut Shin, Christopher aut Quesada, Arnulfo aut Dong, Chuanhui aut Haubenberger, Dietrich aut Hallett, Mark aut Enthalten in NeuroRX Springer-Verlag, 2006 9(2012), 3 vom: 28. März, Seite 635-638 (DE-627)SPR031264964 nnns volume:9 year:2012 number:3 day:28 month:03 pages:635-638 https://dx.doi.org/10.1007/s13311-012-0121-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 9 2012 3 28 03 635-638 |
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10.1007/s13311-012-0121-1 doi (DE-627)SPR031267270 (SPR)s13311-012-0121-1-e DE-627 ger DE-627 rakwb eng Nahab, Fatta B. verfasserin aut Octanoic Acid Suppresses Harmaline-Induced Tremor in Mouse Model of Essential Tremor 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The American Society for Experimental NeuroTherapeutics, Inc. (outside the U.S.) 2012 Abstract Recent work exploring the use of high-molecular weight alcohols to treat essential tremor (ET) has identified octanoic acid as a potential novel tremor-suppressing agent. We used an established harmaline-based mouse model of ET to compare tremor suppression by 1-octanol and octanoic acid. The dose-related effect on digitized motion power within the tremor bandwidth as a fraction of overall motion power was analyzed. Both 1-octanol and octanoic acid provided significant reductions in harmaline tremor. An 8-carbon alkyl alcohol and carboxylic acid each suppress tremor in a pre-clinical mouse model of ET. Further studies are warranted to determine the safety and efficacy of such agents in humans with ET. 1-octanol (dpeaa)DE-He213 Octanoic acid (dpeaa)DE-He213 Essential tremor (dpeaa)DE-He213 Harmaline (dpeaa)DE-He213 Therapeutics (dpeaa)DE-He213 Handforth, Adrian aut Brown, Tyler aut Shin, Christopher aut Quesada, Arnulfo aut Dong, Chuanhui aut Haubenberger, Dietrich aut Hallett, Mark aut Enthalten in NeuroRX Springer-Verlag, 2006 9(2012), 3 vom: 28. März, Seite 635-638 (DE-627)SPR031264964 nnns volume:9 year:2012 number:3 day:28 month:03 pages:635-638 https://dx.doi.org/10.1007/s13311-012-0121-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 9 2012 3 28 03 635-638 |
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10.1007/s13311-012-0121-1 doi (DE-627)SPR031267270 (SPR)s13311-012-0121-1-e DE-627 ger DE-627 rakwb eng Nahab, Fatta B. verfasserin aut Octanoic Acid Suppresses Harmaline-Induced Tremor in Mouse Model of Essential Tremor 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The American Society for Experimental NeuroTherapeutics, Inc. (outside the U.S.) 2012 Abstract Recent work exploring the use of high-molecular weight alcohols to treat essential tremor (ET) has identified octanoic acid as a potential novel tremor-suppressing agent. We used an established harmaline-based mouse model of ET to compare tremor suppression by 1-octanol and octanoic acid. The dose-related effect on digitized motion power within the tremor bandwidth as a fraction of overall motion power was analyzed. Both 1-octanol and octanoic acid provided significant reductions in harmaline tremor. An 8-carbon alkyl alcohol and carboxylic acid each suppress tremor in a pre-clinical mouse model of ET. Further studies are warranted to determine the safety and efficacy of such agents in humans with ET. 1-octanol (dpeaa)DE-He213 Octanoic acid (dpeaa)DE-He213 Essential tremor (dpeaa)DE-He213 Harmaline (dpeaa)DE-He213 Therapeutics (dpeaa)DE-He213 Handforth, Adrian aut Brown, Tyler aut Shin, Christopher aut Quesada, Arnulfo aut Dong, Chuanhui aut Haubenberger, Dietrich aut Hallett, Mark aut Enthalten in NeuroRX Springer-Verlag, 2006 9(2012), 3 vom: 28. März, Seite 635-638 (DE-627)SPR031264964 nnns volume:9 year:2012 number:3 day:28 month:03 pages:635-638 https://dx.doi.org/10.1007/s13311-012-0121-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 9 2012 3 28 03 635-638 |
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10.1007/s13311-012-0121-1 doi (DE-627)SPR031267270 (SPR)s13311-012-0121-1-e DE-627 ger DE-627 rakwb eng Nahab, Fatta B. verfasserin aut Octanoic Acid Suppresses Harmaline-Induced Tremor in Mouse Model of Essential Tremor 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The American Society for Experimental NeuroTherapeutics, Inc. (outside the U.S.) 2012 Abstract Recent work exploring the use of high-molecular weight alcohols to treat essential tremor (ET) has identified octanoic acid as a potential novel tremor-suppressing agent. We used an established harmaline-based mouse model of ET to compare tremor suppression by 1-octanol and octanoic acid. The dose-related effect on digitized motion power within the tremor bandwidth as a fraction of overall motion power was analyzed. Both 1-octanol and octanoic acid provided significant reductions in harmaline tremor. An 8-carbon alkyl alcohol and carboxylic acid each suppress tremor in a pre-clinical mouse model of ET. Further studies are warranted to determine the safety and efficacy of such agents in humans with ET. 1-octanol (dpeaa)DE-He213 Octanoic acid (dpeaa)DE-He213 Essential tremor (dpeaa)DE-He213 Harmaline (dpeaa)DE-He213 Therapeutics (dpeaa)DE-He213 Handforth, Adrian aut Brown, Tyler aut Shin, Christopher aut Quesada, Arnulfo aut Dong, Chuanhui aut Haubenberger, Dietrich aut Hallett, Mark aut Enthalten in NeuroRX Springer-Verlag, 2006 9(2012), 3 vom: 28. März, Seite 635-638 (DE-627)SPR031264964 nnns volume:9 year:2012 number:3 day:28 month:03 pages:635-638 https://dx.doi.org/10.1007/s13311-012-0121-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 9 2012 3 28 03 635-638 |
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octanoic acid suppresses harmaline-induced tremor in mouse model of essential tremor |
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Octanoic Acid Suppresses Harmaline-Induced Tremor in Mouse Model of Essential Tremor |
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Abstract Recent work exploring the use of high-molecular weight alcohols to treat essential tremor (ET) has identified octanoic acid as a potential novel tremor-suppressing agent. We used an established harmaline-based mouse model of ET to compare tremor suppression by 1-octanol and octanoic acid. The dose-related effect on digitized motion power within the tremor bandwidth as a fraction of overall motion power was analyzed. Both 1-octanol and octanoic acid provided significant reductions in harmaline tremor. An 8-carbon alkyl alcohol and carboxylic acid each suppress tremor in a pre-clinical mouse model of ET. Further studies are warranted to determine the safety and efficacy of such agents in humans with ET. © The American Society for Experimental NeuroTherapeutics, Inc. (outside the U.S.) 2012 |
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Abstract Recent work exploring the use of high-molecular weight alcohols to treat essential tremor (ET) has identified octanoic acid as a potential novel tremor-suppressing agent. We used an established harmaline-based mouse model of ET to compare tremor suppression by 1-octanol and octanoic acid. The dose-related effect on digitized motion power within the tremor bandwidth as a fraction of overall motion power was analyzed. Both 1-octanol and octanoic acid provided significant reductions in harmaline tremor. An 8-carbon alkyl alcohol and carboxylic acid each suppress tremor in a pre-clinical mouse model of ET. Further studies are warranted to determine the safety and efficacy of such agents in humans with ET. © The American Society for Experimental NeuroTherapeutics, Inc. (outside the U.S.) 2012 |
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Abstract Recent work exploring the use of high-molecular weight alcohols to treat essential tremor (ET) has identified octanoic acid as a potential novel tremor-suppressing agent. We used an established harmaline-based mouse model of ET to compare tremor suppression by 1-octanol and octanoic acid. The dose-related effect on digitized motion power within the tremor bandwidth as a fraction of overall motion power was analyzed. Both 1-octanol and octanoic acid provided significant reductions in harmaline tremor. An 8-carbon alkyl alcohol and carboxylic acid each suppress tremor in a pre-clinical mouse model of ET. Further studies are warranted to determine the safety and efficacy of such agents in humans with ET. © The American Society for Experimental NeuroTherapeutics, Inc. (outside the U.S.) 2012 |
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Handforth, Adrian Brown, Tyler Shin, Christopher Quesada, Arnulfo Dong, Chuanhui Haubenberger, Dietrich Hallett, Mark |
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Handforth, Adrian Brown, Tyler Shin, Christopher Quesada, Arnulfo Dong, Chuanhui Haubenberger, Dietrich Hallett, Mark |
| ppnlink |
SPR031264964 |
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c |
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| doi_str |
10.1007/s13311-012-0121-1 |
| up_date |
2024-07-03T22:56:50.075Z |
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