Evaluation of surrogate markers for insulin resistance for defining metabolic syndrome in urban Indian adolescents
Objective To compare parameters of insulin resistance, with special reference to McAuley index, in urban Indian adolescents, and to establish their cut-off values for defining metabolic syndrome. Design Cross-sectional study. Setting Schools located in four different geographical zones of Delhi, Ind...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Garg, M. K. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Schlagwörter: |
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| Anmerkung: |
© Indian Academy of Pediatrics 2014 |
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| Übergeordnetes Werk: |
Enthalten in: Indian Pediatrics - Springer-Verlag, 2010, 51(2014), 4 vom: Apr., Seite 279-284 |
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| Übergeordnetes Werk: |
volume:51 ; year:2014 ; number:4 ; month:04 ; pages:279-284 |
| Links: |
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| DOI / URN: |
10.1007/s13312-014-0401-4 |
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SPR031286119 |
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| 520 | |a Objective To compare parameters of insulin resistance, with special reference to McAuley index, in urban Indian adolescents, and to establish their cut-off values for defining metabolic syndrome. Design Cross-sectional study. Setting Schools located in four different geographical zones of Delhi, India. Participants 695 apparently healthy adolescents grouped as normal weight (298), overweight (205) and obese (192). Outcome measures Cut-off point for indices of insulin resistance was assessed by fasting insulin, insulin glucose ratio, and other methods (HOMA model, QUICKI, McAuley index) to define metabolic syndrome. Results The McAuley index increased progressively from normal weight to obese adolescents in both sexes. McAuley index was significantly lower in adolescents with metabolic syndrome (5.36 ± 1.28 vs. 7.05 ± 1.88; P<0.001). McAuley index had the highest area under curve of receiver operator characteristics [0.82 (0.02)] as compared to other indices of insulin resistance. McAuley index of 6.23 had the highest specificity (88%) with sensitivity of 63.3% for diagnosing metabolic syndrome, whereas insulin glucose ratio had the highest sensitivity (79.7%) but low (55.5%) specificity. McAuley index was negatively correlated with height (r= −0.257, P=<0.001), weight (r= −0.537, P=<0.001), body mass index (r= −0.579, P<0.001), waist circumference (r= −0.542, p<0.001), and waist hip ratio (r= −0.268, P<0.001). Conclusions Among various parameters of insulin resistance, McAuley index had the highest specificity, and insulin glucose ratio had the highest sensitivity in diagnosing metabolic syndrome in urban Indian adolescents. | ||
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| 700 | 1 | |a Singh, Yashpal |4 aut | |
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10.1007/s13312-014-0401-4 doi (DE-627)SPR031286119 (SPR)s13312-014-0401-4-e DE-627 ger DE-627 rakwb eng Garg, M. K. verfasserin aut Evaluation of surrogate markers for insulin resistance for defining metabolic syndrome in urban Indian adolescents 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Indian Academy of Pediatrics 2014 Objective To compare parameters of insulin resistance, with special reference to McAuley index, in urban Indian adolescents, and to establish their cut-off values for defining metabolic syndrome. Design Cross-sectional study. Setting Schools located in four different geographical zones of Delhi, India. Participants 695 apparently healthy adolescents grouped as normal weight (298), overweight (205) and obese (192). Outcome measures Cut-off point for indices of insulin resistance was assessed by fasting insulin, insulin glucose ratio, and other methods (HOMA model, QUICKI, McAuley index) to define metabolic syndrome. Results The McAuley index increased progressively from normal weight to obese adolescents in both sexes. McAuley index was significantly lower in adolescents with metabolic syndrome (5.36 ± 1.28 vs. 7.05 ± 1.88; P<0.001). McAuley index had the highest area under curve of receiver operator characteristics [0.82 (0.02)] as compared to other indices of insulin resistance. McAuley index of 6.23 had the highest specificity (88%) with sensitivity of 63.3% for diagnosing metabolic syndrome, whereas insulin glucose ratio had the highest sensitivity (79.7%) but low (55.5%) specificity. McAuley index was negatively correlated with height (r= −0.257, P=<0.001), weight (r= −0.537, P=<0.001), body mass index (r= −0.579, P<0.001), waist circumference (r= −0.542, p<0.001), and waist hip ratio (r= −0.268, P<0.001). Conclusions Among various parameters of insulin resistance, McAuley index had the highest specificity, and insulin glucose ratio had the highest sensitivity in diagnosing metabolic syndrome in urban Indian adolescents. Diabetes (dpeaa)DE-He213 Hypertrigyceridemia (dpeaa)DE-He213 Insulin resistance (dpeaa)DE-He213 Waist circumference (dpeaa)DE-He213 Waist-hip ratio (dpeaa)DE-He213 Tandon, Nikhil aut Marwaha, R. K. aut Singh, Yashpal aut Enthalten in Indian Pediatrics Springer-Verlag, 2010 51(2014), 4 vom: Apr., Seite 279-284 (DE-627)SPR031274943 nnns volume:51 year:2014 number:4 month:04 pages:279-284 https://dx.doi.org/10.1007/s13312-014-0401-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_70 GBV_ILN_72 GBV_ILN_110 GBV_ILN_131 GBV_ILN_160 GBV_ILN_376 GBV_ILN_607 AR 51 2014 4 04 279-284 |
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10.1007/s13312-014-0401-4 doi (DE-627)SPR031286119 (SPR)s13312-014-0401-4-e DE-627 ger DE-627 rakwb eng Garg, M. K. verfasserin aut Evaluation of surrogate markers for insulin resistance for defining metabolic syndrome in urban Indian adolescents 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Indian Academy of Pediatrics 2014 Objective To compare parameters of insulin resistance, with special reference to McAuley index, in urban Indian adolescents, and to establish their cut-off values for defining metabolic syndrome. Design Cross-sectional study. Setting Schools located in four different geographical zones of Delhi, India. Participants 695 apparently healthy adolescents grouped as normal weight (298), overweight (205) and obese (192). Outcome measures Cut-off point for indices of insulin resistance was assessed by fasting insulin, insulin glucose ratio, and other methods (HOMA model, QUICKI, McAuley index) to define metabolic syndrome. Results The McAuley index increased progressively from normal weight to obese adolescents in both sexes. McAuley index was significantly lower in adolescents with metabolic syndrome (5.36 ± 1.28 vs. 7.05 ± 1.88; P<0.001). McAuley index had the highest area under curve of receiver operator characteristics [0.82 (0.02)] as compared to other indices of insulin resistance. McAuley index of 6.23 had the highest specificity (88%) with sensitivity of 63.3% for diagnosing metabolic syndrome, whereas insulin glucose ratio had the highest sensitivity (79.7%) but low (55.5%) specificity. McAuley index was negatively correlated with height (r= −0.257, P=<0.001), weight (r= −0.537, P=<0.001), body mass index (r= −0.579, P<0.001), waist circumference (r= −0.542, p<0.001), and waist hip ratio (r= −0.268, P<0.001). Conclusions Among various parameters of insulin resistance, McAuley index had the highest specificity, and insulin glucose ratio had the highest sensitivity in diagnosing metabolic syndrome in urban Indian adolescents. Diabetes (dpeaa)DE-He213 Hypertrigyceridemia (dpeaa)DE-He213 Insulin resistance (dpeaa)DE-He213 Waist circumference (dpeaa)DE-He213 Waist-hip ratio (dpeaa)DE-He213 Tandon, Nikhil aut Marwaha, R. K. aut Singh, Yashpal aut Enthalten in Indian Pediatrics Springer-Verlag, 2010 51(2014), 4 vom: Apr., Seite 279-284 (DE-627)SPR031274943 nnns volume:51 year:2014 number:4 month:04 pages:279-284 https://dx.doi.org/10.1007/s13312-014-0401-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_70 GBV_ILN_72 GBV_ILN_110 GBV_ILN_131 GBV_ILN_160 GBV_ILN_376 GBV_ILN_607 AR 51 2014 4 04 279-284 |
| allfields_unstemmed |
10.1007/s13312-014-0401-4 doi (DE-627)SPR031286119 (SPR)s13312-014-0401-4-e DE-627 ger DE-627 rakwb eng Garg, M. K. verfasserin aut Evaluation of surrogate markers for insulin resistance for defining metabolic syndrome in urban Indian adolescents 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Indian Academy of Pediatrics 2014 Objective To compare parameters of insulin resistance, with special reference to McAuley index, in urban Indian adolescents, and to establish their cut-off values for defining metabolic syndrome. Design Cross-sectional study. Setting Schools located in four different geographical zones of Delhi, India. Participants 695 apparently healthy adolescents grouped as normal weight (298), overweight (205) and obese (192). Outcome measures Cut-off point for indices of insulin resistance was assessed by fasting insulin, insulin glucose ratio, and other methods (HOMA model, QUICKI, McAuley index) to define metabolic syndrome. Results The McAuley index increased progressively from normal weight to obese adolescents in both sexes. McAuley index was significantly lower in adolescents with metabolic syndrome (5.36 ± 1.28 vs. 7.05 ± 1.88; P<0.001). McAuley index had the highest area under curve of receiver operator characteristics [0.82 (0.02)] as compared to other indices of insulin resistance. McAuley index of 6.23 had the highest specificity (88%) with sensitivity of 63.3% for diagnosing metabolic syndrome, whereas insulin glucose ratio had the highest sensitivity (79.7%) but low (55.5%) specificity. McAuley index was negatively correlated with height (r= −0.257, P=<0.001), weight (r= −0.537, P=<0.001), body mass index (r= −0.579, P<0.001), waist circumference (r= −0.542, p<0.001), and waist hip ratio (r= −0.268, P<0.001). Conclusions Among various parameters of insulin resistance, McAuley index had the highest specificity, and insulin glucose ratio had the highest sensitivity in diagnosing metabolic syndrome in urban Indian adolescents. Diabetes (dpeaa)DE-He213 Hypertrigyceridemia (dpeaa)DE-He213 Insulin resistance (dpeaa)DE-He213 Waist circumference (dpeaa)DE-He213 Waist-hip ratio (dpeaa)DE-He213 Tandon, Nikhil aut Marwaha, R. K. aut Singh, Yashpal aut Enthalten in Indian Pediatrics Springer-Verlag, 2010 51(2014), 4 vom: Apr., Seite 279-284 (DE-627)SPR031274943 nnns volume:51 year:2014 number:4 month:04 pages:279-284 https://dx.doi.org/10.1007/s13312-014-0401-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_70 GBV_ILN_72 GBV_ILN_110 GBV_ILN_131 GBV_ILN_160 GBV_ILN_376 GBV_ILN_607 AR 51 2014 4 04 279-284 |
| allfieldsGer |
10.1007/s13312-014-0401-4 doi (DE-627)SPR031286119 (SPR)s13312-014-0401-4-e DE-627 ger DE-627 rakwb eng Garg, M. K. verfasserin aut Evaluation of surrogate markers for insulin resistance for defining metabolic syndrome in urban Indian adolescents 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Indian Academy of Pediatrics 2014 Objective To compare parameters of insulin resistance, with special reference to McAuley index, in urban Indian adolescents, and to establish their cut-off values for defining metabolic syndrome. Design Cross-sectional study. Setting Schools located in four different geographical zones of Delhi, India. Participants 695 apparently healthy adolescents grouped as normal weight (298), overweight (205) and obese (192). Outcome measures Cut-off point for indices of insulin resistance was assessed by fasting insulin, insulin glucose ratio, and other methods (HOMA model, QUICKI, McAuley index) to define metabolic syndrome. Results The McAuley index increased progressively from normal weight to obese adolescents in both sexes. McAuley index was significantly lower in adolescents with metabolic syndrome (5.36 ± 1.28 vs. 7.05 ± 1.88; P<0.001). McAuley index had the highest area under curve of receiver operator characteristics [0.82 (0.02)] as compared to other indices of insulin resistance. McAuley index of 6.23 had the highest specificity (88%) with sensitivity of 63.3% for diagnosing metabolic syndrome, whereas insulin glucose ratio had the highest sensitivity (79.7%) but low (55.5%) specificity. McAuley index was negatively correlated with height (r= −0.257, P=<0.001), weight (r= −0.537, P=<0.001), body mass index (r= −0.579, P<0.001), waist circumference (r= −0.542, p<0.001), and waist hip ratio (r= −0.268, P<0.001). Conclusions Among various parameters of insulin resistance, McAuley index had the highest specificity, and insulin glucose ratio had the highest sensitivity in diagnosing metabolic syndrome in urban Indian adolescents. Diabetes (dpeaa)DE-He213 Hypertrigyceridemia (dpeaa)DE-He213 Insulin resistance (dpeaa)DE-He213 Waist circumference (dpeaa)DE-He213 Waist-hip ratio (dpeaa)DE-He213 Tandon, Nikhil aut Marwaha, R. K. aut Singh, Yashpal aut Enthalten in Indian Pediatrics Springer-Verlag, 2010 51(2014), 4 vom: Apr., Seite 279-284 (DE-627)SPR031274943 nnns volume:51 year:2014 number:4 month:04 pages:279-284 https://dx.doi.org/10.1007/s13312-014-0401-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_70 GBV_ILN_72 GBV_ILN_110 GBV_ILN_131 GBV_ILN_160 GBV_ILN_376 GBV_ILN_607 AR 51 2014 4 04 279-284 |
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10.1007/s13312-014-0401-4 doi (DE-627)SPR031286119 (SPR)s13312-014-0401-4-e DE-627 ger DE-627 rakwb eng Garg, M. K. verfasserin aut Evaluation of surrogate markers for insulin resistance for defining metabolic syndrome in urban Indian adolescents 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Indian Academy of Pediatrics 2014 Objective To compare parameters of insulin resistance, with special reference to McAuley index, in urban Indian adolescents, and to establish their cut-off values for defining metabolic syndrome. Design Cross-sectional study. Setting Schools located in four different geographical zones of Delhi, India. Participants 695 apparently healthy adolescents grouped as normal weight (298), overweight (205) and obese (192). Outcome measures Cut-off point for indices of insulin resistance was assessed by fasting insulin, insulin glucose ratio, and other methods (HOMA model, QUICKI, McAuley index) to define metabolic syndrome. Results The McAuley index increased progressively from normal weight to obese adolescents in both sexes. McAuley index was significantly lower in adolescents with metabolic syndrome (5.36 ± 1.28 vs. 7.05 ± 1.88; P<0.001). McAuley index had the highest area under curve of receiver operator characteristics [0.82 (0.02)] as compared to other indices of insulin resistance. McAuley index of 6.23 had the highest specificity (88%) with sensitivity of 63.3% for diagnosing metabolic syndrome, whereas insulin glucose ratio had the highest sensitivity (79.7%) but low (55.5%) specificity. McAuley index was negatively correlated with height (r= −0.257, P=<0.001), weight (r= −0.537, P=<0.001), body mass index (r= −0.579, P<0.001), waist circumference (r= −0.542, p<0.001), and waist hip ratio (r= −0.268, P<0.001). Conclusions Among various parameters of insulin resistance, McAuley index had the highest specificity, and insulin glucose ratio had the highest sensitivity in diagnosing metabolic syndrome in urban Indian adolescents. Diabetes (dpeaa)DE-He213 Hypertrigyceridemia (dpeaa)DE-He213 Insulin resistance (dpeaa)DE-He213 Waist circumference (dpeaa)DE-He213 Waist-hip ratio (dpeaa)DE-He213 Tandon, Nikhil aut Marwaha, R. K. aut Singh, Yashpal aut Enthalten in Indian Pediatrics Springer-Verlag, 2010 51(2014), 4 vom: Apr., Seite 279-284 (DE-627)SPR031274943 nnns volume:51 year:2014 number:4 month:04 pages:279-284 https://dx.doi.org/10.1007/s13312-014-0401-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_70 GBV_ILN_72 GBV_ILN_110 GBV_ILN_131 GBV_ILN_160 GBV_ILN_376 GBV_ILN_607 AR 51 2014 4 04 279-284 |
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K.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Evaluation of surrogate markers for insulin resistance for defining metabolic syndrome in urban Indian adolescents</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2014</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Indian Academy of Pediatrics 2014</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Objective To compare parameters of insulin resistance, with special reference to McAuley index, in urban Indian adolescents, and to establish their cut-off values for defining metabolic syndrome. Design Cross-sectional study. Setting Schools located in four different geographical zones of Delhi, India. Participants 695 apparently healthy adolescents grouped as normal weight (298), overweight (205) and obese (192). Outcome measures Cut-off point for indices of insulin resistance was assessed by fasting insulin, insulin glucose ratio, and other methods (HOMA model, QUICKI, McAuley index) to define metabolic syndrome. Results The McAuley index increased progressively from normal weight to obese adolescents in both sexes. McAuley index was significantly lower in adolescents with metabolic syndrome (5.36 ± 1.28 vs. 7.05 ± 1.88; P<0.001). McAuley index had the highest area under curve of receiver operator characteristics [0.82 (0.02)] as compared to other indices of insulin resistance. McAuley index of 6.23 had the highest specificity (88%) with sensitivity of 63.3% for diagnosing metabolic syndrome, whereas insulin glucose ratio had the highest sensitivity (79.7%) but low (55.5%) specificity. McAuley index was negatively correlated with height (r= −0.257, P=<0.001), weight (r= −0.537, P=<0.001), body mass index (r= −0.579, P<0.001), waist circumference (r= −0.542, p<0.001), and waist hip ratio (r= −0.268, P<0.001). 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evaluation of surrogate markers for insulin resistance for defining metabolic syndrome in urban indian adolescents |
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Evaluation of surrogate markers for insulin resistance for defining metabolic syndrome in urban Indian adolescents |
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Objective To compare parameters of insulin resistance, with special reference to McAuley index, in urban Indian adolescents, and to establish their cut-off values for defining metabolic syndrome. Design Cross-sectional study. Setting Schools located in four different geographical zones of Delhi, India. Participants 695 apparently healthy adolescents grouped as normal weight (298), overweight (205) and obese (192). Outcome measures Cut-off point for indices of insulin resistance was assessed by fasting insulin, insulin glucose ratio, and other methods (HOMA model, QUICKI, McAuley index) to define metabolic syndrome. Results The McAuley index increased progressively from normal weight to obese adolescents in both sexes. McAuley index was significantly lower in adolescents with metabolic syndrome (5.36 ± 1.28 vs. 7.05 ± 1.88; P<0.001). McAuley index had the highest area under curve of receiver operator characteristics [0.82 (0.02)] as compared to other indices of insulin resistance. McAuley index of 6.23 had the highest specificity (88%) with sensitivity of 63.3% for diagnosing metabolic syndrome, whereas insulin glucose ratio had the highest sensitivity (79.7%) but low (55.5%) specificity. McAuley index was negatively correlated with height (r= −0.257, P=<0.001), weight (r= −0.537, P=<0.001), body mass index (r= −0.579, P<0.001), waist circumference (r= −0.542, p<0.001), and waist hip ratio (r= −0.268, P<0.001). Conclusions Among various parameters of insulin resistance, McAuley index had the highest specificity, and insulin glucose ratio had the highest sensitivity in diagnosing metabolic syndrome in urban Indian adolescents. © Indian Academy of Pediatrics 2014 |
| abstractGer |
Objective To compare parameters of insulin resistance, with special reference to McAuley index, in urban Indian adolescents, and to establish their cut-off values for defining metabolic syndrome. Design Cross-sectional study. Setting Schools located in four different geographical zones of Delhi, India. Participants 695 apparently healthy adolescents grouped as normal weight (298), overweight (205) and obese (192). Outcome measures Cut-off point for indices of insulin resistance was assessed by fasting insulin, insulin glucose ratio, and other methods (HOMA model, QUICKI, McAuley index) to define metabolic syndrome. Results The McAuley index increased progressively from normal weight to obese adolescents in both sexes. McAuley index was significantly lower in adolescents with metabolic syndrome (5.36 ± 1.28 vs. 7.05 ± 1.88; P<0.001). McAuley index had the highest area under curve of receiver operator characteristics [0.82 (0.02)] as compared to other indices of insulin resistance. McAuley index of 6.23 had the highest specificity (88%) with sensitivity of 63.3% for diagnosing metabolic syndrome, whereas insulin glucose ratio had the highest sensitivity (79.7%) but low (55.5%) specificity. McAuley index was negatively correlated with height (r= −0.257, P=<0.001), weight (r= −0.537, P=<0.001), body mass index (r= −0.579, P<0.001), waist circumference (r= −0.542, p<0.001), and waist hip ratio (r= −0.268, P<0.001). Conclusions Among various parameters of insulin resistance, McAuley index had the highest specificity, and insulin glucose ratio had the highest sensitivity in diagnosing metabolic syndrome in urban Indian adolescents. © Indian Academy of Pediatrics 2014 |
| abstract_unstemmed |
Objective To compare parameters of insulin resistance, with special reference to McAuley index, in urban Indian adolescents, and to establish their cut-off values for defining metabolic syndrome. Design Cross-sectional study. Setting Schools located in four different geographical zones of Delhi, India. Participants 695 apparently healthy adolescents grouped as normal weight (298), overweight (205) and obese (192). Outcome measures Cut-off point for indices of insulin resistance was assessed by fasting insulin, insulin glucose ratio, and other methods (HOMA model, QUICKI, McAuley index) to define metabolic syndrome. Results The McAuley index increased progressively from normal weight to obese adolescents in both sexes. McAuley index was significantly lower in adolescents with metabolic syndrome (5.36 ± 1.28 vs. 7.05 ± 1.88; P<0.001). McAuley index had the highest area under curve of receiver operator characteristics [0.82 (0.02)] as compared to other indices of insulin resistance. McAuley index of 6.23 had the highest specificity (88%) with sensitivity of 63.3% for diagnosing metabolic syndrome, whereas insulin glucose ratio had the highest sensitivity (79.7%) but low (55.5%) specificity. McAuley index was negatively correlated with height (r= −0.257, P=<0.001), weight (r= −0.537, P=<0.001), body mass index (r= −0.579, P<0.001), waist circumference (r= −0.542, p<0.001), and waist hip ratio (r= −0.268, P<0.001). Conclusions Among various parameters of insulin resistance, McAuley index had the highest specificity, and insulin glucose ratio had the highest sensitivity in diagnosing metabolic syndrome in urban Indian adolescents. © Indian Academy of Pediatrics 2014 |
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