Bone mineral density of Indian children and adolescents with cystic fibrosis
Objectives To document bone mineral density of children and adolescents with cystic fibrosis. Design Cross-sectional study. Setting Tertiary-care center of Northern India, July 2012 to August 2015. Participants 52 children aged 6-18 years with cystic fibrosis and 62 healthy controls of similar age a...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Gupta, Sumita [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Anmerkung: |
© Indian Academy of Pediatrics 2017 |
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| Übergeordnetes Werk: |
Enthalten in: Indian Pediatrics - Springer-Verlag, 2010, 54(2017), 7 vom: Juli, Seite 545-549 |
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| Übergeordnetes Werk: |
volume:54 ; year:2017 ; number:7 ; month:07 ; pages:545-549 |
| Links: |
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| DOI / URN: |
10.1007/s13312-017-1065-7 |
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SPR031293913 |
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| 520 | |a Objectives To document bone mineral density of children and adolescents with cystic fibrosis. Design Cross-sectional study. Setting Tertiary-care center of Northern India, July 2012 to August 2015. Participants 52 children aged 6-18 years with cystic fibrosis and 62 healthy controls of similar age and sex. Methods Both patients and controls were stratified into two groups, as pre-pubertal and peri-/post-pubertal, and compared for whole body bone mineral density, measured using dual energy X-ray absorptiometry. Serum levels of calcium, phosphate, alkaline phosphatase, 25-hydroxyvitamin D and parathyroid hormone were measured in children with cystic fibrosis. Results Compared with controls, the mean (SD) bone mineral density of children with cystic fibrosis was significantly lower in both the pre-pubertal (0.7 (0.1) g/$ cm^{2} $vs 0.9 (0.1) g/$ cm^{2} $; P<0.001)) and peri-/post-pubertal groups (0.9 (0.1) g/$ cm^{2} $vs 1.1 (0.1) g/$ cm^{2} $; P<0.001). Also, the mean (SD) bone mineral apparent density of pre-pubertal and peri-/post-pubertal cystic fibrosis patients was lower than the controls (P<0.001 and P= 0.01, respectively). Thirty-seven (71.2%) cystic fibrosis patients had serum 25-hydroxyvitamin D level below 15 ng/mL. Conclusion Bone mineral density of children with cystic fibrosis was significantly lower than controls; majority of them were vitamin-D deficient. Intervening at an early stage of the disease and providing optimal therapy involving simultaneous management of the several factors affecting bone mineral accretion may be beneficial in improving bone health of these patients. | ||
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| 700 | 1 | |a Lodha, Rakesh |4 aut | |
| 700 | 1 | |a Kabra, Sushil K. |4 aut | |
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10.1007/s13312-017-1065-7 doi (DE-627)SPR031293913 (SPR)s13312-017-1065-7-e DE-627 ger DE-627 rakwb eng Gupta, Sumita verfasserin aut Bone mineral density of Indian children and adolescents with cystic fibrosis 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Indian Academy of Pediatrics 2017 Objectives To document bone mineral density of children and adolescents with cystic fibrosis. Design Cross-sectional study. Setting Tertiary-care center of Northern India, July 2012 to August 2015. Participants 52 children aged 6-18 years with cystic fibrosis and 62 healthy controls of similar age and sex. Methods Both patients and controls were stratified into two groups, as pre-pubertal and peri-/post-pubertal, and compared for whole body bone mineral density, measured using dual energy X-ray absorptiometry. Serum levels of calcium, phosphate, alkaline phosphatase, 25-hydroxyvitamin D and parathyroid hormone were measured in children with cystic fibrosis. Results Compared with controls, the mean (SD) bone mineral density of children with cystic fibrosis was significantly lower in both the pre-pubertal (0.7 (0.1) g/$ cm^{2} $vs 0.9 (0.1) g/$ cm^{2} $; P<0.001)) and peri-/post-pubertal groups (0.9 (0.1) g/$ cm^{2} $vs 1.1 (0.1) g/$ cm^{2} $; P<0.001). Also, the mean (SD) bone mineral apparent density of pre-pubertal and peri-/post-pubertal cystic fibrosis patients was lower than the controls (P<0.001 and P= 0.01, respectively). Thirty-seven (71.2%) cystic fibrosis patients had serum 25-hydroxyvitamin D level below 15 ng/mL. Conclusion Bone mineral density of children with cystic fibrosis was significantly lower than controls; majority of them were vitamin-D deficient. Intervening at an early stage of the disease and providing optimal therapy involving simultaneous management of the several factors affecting bone mineral accretion may be beneficial in improving bone health of these patients. Bone health (dpeaa)DE-He213 Chronic illness (dpeaa)DE-He213 Dual energy X-ray absorptiometry (dpeaa)DE-He213 Vitamin D (dpeaa)DE-He213 Mukherjee, Aparna aut Khadgawat, Rajesh aut Kabra, Madhulika aut Lodha, Rakesh aut Kabra, Sushil K. aut Enthalten in Indian Pediatrics Springer-Verlag, 2010 54(2017), 7 vom: Juli, Seite 545-549 (DE-627)SPR031274943 nnns volume:54 year:2017 number:7 month:07 pages:545-549 https://dx.doi.org/10.1007/s13312-017-1065-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_70 GBV_ILN_72 GBV_ILN_110 GBV_ILN_131 GBV_ILN_160 GBV_ILN_376 GBV_ILN_607 AR 54 2017 7 07 545-549 |
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10.1007/s13312-017-1065-7 doi (DE-627)SPR031293913 (SPR)s13312-017-1065-7-e DE-627 ger DE-627 rakwb eng Gupta, Sumita verfasserin aut Bone mineral density of Indian children and adolescents with cystic fibrosis 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Indian Academy of Pediatrics 2017 Objectives To document bone mineral density of children and adolescents with cystic fibrosis. Design Cross-sectional study. Setting Tertiary-care center of Northern India, July 2012 to August 2015. Participants 52 children aged 6-18 years with cystic fibrosis and 62 healthy controls of similar age and sex. Methods Both patients and controls were stratified into two groups, as pre-pubertal and peri-/post-pubertal, and compared for whole body bone mineral density, measured using dual energy X-ray absorptiometry. Serum levels of calcium, phosphate, alkaline phosphatase, 25-hydroxyvitamin D and parathyroid hormone were measured in children with cystic fibrosis. Results Compared with controls, the mean (SD) bone mineral density of children with cystic fibrosis was significantly lower in both the pre-pubertal (0.7 (0.1) g/$ cm^{2} $vs 0.9 (0.1) g/$ cm^{2} $; P<0.001)) and peri-/post-pubertal groups (0.9 (0.1) g/$ cm^{2} $vs 1.1 (0.1) g/$ cm^{2} $; P<0.001). Also, the mean (SD) bone mineral apparent density of pre-pubertal and peri-/post-pubertal cystic fibrosis patients was lower than the controls (P<0.001 and P= 0.01, respectively). Thirty-seven (71.2%) cystic fibrosis patients had serum 25-hydroxyvitamin D level below 15 ng/mL. Conclusion Bone mineral density of children with cystic fibrosis was significantly lower than controls; majority of them were vitamin-D deficient. Intervening at an early stage of the disease and providing optimal therapy involving simultaneous management of the several factors affecting bone mineral accretion may be beneficial in improving bone health of these patients. Bone health (dpeaa)DE-He213 Chronic illness (dpeaa)DE-He213 Dual energy X-ray absorptiometry (dpeaa)DE-He213 Vitamin D (dpeaa)DE-He213 Mukherjee, Aparna aut Khadgawat, Rajesh aut Kabra, Madhulika aut Lodha, Rakesh aut Kabra, Sushil K. aut Enthalten in Indian Pediatrics Springer-Verlag, 2010 54(2017), 7 vom: Juli, Seite 545-549 (DE-627)SPR031274943 nnns volume:54 year:2017 number:7 month:07 pages:545-549 https://dx.doi.org/10.1007/s13312-017-1065-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_70 GBV_ILN_72 GBV_ILN_110 GBV_ILN_131 GBV_ILN_160 GBV_ILN_376 GBV_ILN_607 AR 54 2017 7 07 545-549 |
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10.1007/s13312-017-1065-7 doi (DE-627)SPR031293913 (SPR)s13312-017-1065-7-e DE-627 ger DE-627 rakwb eng Gupta, Sumita verfasserin aut Bone mineral density of Indian children and adolescents with cystic fibrosis 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Indian Academy of Pediatrics 2017 Objectives To document bone mineral density of children and adolescents with cystic fibrosis. Design Cross-sectional study. Setting Tertiary-care center of Northern India, July 2012 to August 2015. Participants 52 children aged 6-18 years with cystic fibrosis and 62 healthy controls of similar age and sex. Methods Both patients and controls were stratified into two groups, as pre-pubertal and peri-/post-pubertal, and compared for whole body bone mineral density, measured using dual energy X-ray absorptiometry. Serum levels of calcium, phosphate, alkaline phosphatase, 25-hydroxyvitamin D and parathyroid hormone were measured in children with cystic fibrosis. Results Compared with controls, the mean (SD) bone mineral density of children with cystic fibrosis was significantly lower in both the pre-pubertal (0.7 (0.1) g/$ cm^{2} $vs 0.9 (0.1) g/$ cm^{2} $; P<0.001)) and peri-/post-pubertal groups (0.9 (0.1) g/$ cm^{2} $vs 1.1 (0.1) g/$ cm^{2} $; P<0.001). Also, the mean (SD) bone mineral apparent density of pre-pubertal and peri-/post-pubertal cystic fibrosis patients was lower than the controls (P<0.001 and P= 0.01, respectively). Thirty-seven (71.2%) cystic fibrosis patients had serum 25-hydroxyvitamin D level below 15 ng/mL. Conclusion Bone mineral density of children with cystic fibrosis was significantly lower than controls; majority of them were vitamin-D deficient. Intervening at an early stage of the disease and providing optimal therapy involving simultaneous management of the several factors affecting bone mineral accretion may be beneficial in improving bone health of these patients. Bone health (dpeaa)DE-He213 Chronic illness (dpeaa)DE-He213 Dual energy X-ray absorptiometry (dpeaa)DE-He213 Vitamin D (dpeaa)DE-He213 Mukherjee, Aparna aut Khadgawat, Rajesh aut Kabra, Madhulika aut Lodha, Rakesh aut Kabra, Sushil K. aut Enthalten in Indian Pediatrics Springer-Verlag, 2010 54(2017), 7 vom: Juli, Seite 545-549 (DE-627)SPR031274943 nnns volume:54 year:2017 number:7 month:07 pages:545-549 https://dx.doi.org/10.1007/s13312-017-1065-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_70 GBV_ILN_72 GBV_ILN_110 GBV_ILN_131 GBV_ILN_160 GBV_ILN_376 GBV_ILN_607 AR 54 2017 7 07 545-549 |
| allfieldsGer |
10.1007/s13312-017-1065-7 doi (DE-627)SPR031293913 (SPR)s13312-017-1065-7-e DE-627 ger DE-627 rakwb eng Gupta, Sumita verfasserin aut Bone mineral density of Indian children and adolescents with cystic fibrosis 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Indian Academy of Pediatrics 2017 Objectives To document bone mineral density of children and adolescents with cystic fibrosis. Design Cross-sectional study. Setting Tertiary-care center of Northern India, July 2012 to August 2015. Participants 52 children aged 6-18 years with cystic fibrosis and 62 healthy controls of similar age and sex. Methods Both patients and controls were stratified into two groups, as pre-pubertal and peri-/post-pubertal, and compared for whole body bone mineral density, measured using dual energy X-ray absorptiometry. Serum levels of calcium, phosphate, alkaline phosphatase, 25-hydroxyvitamin D and parathyroid hormone were measured in children with cystic fibrosis. Results Compared with controls, the mean (SD) bone mineral density of children with cystic fibrosis was significantly lower in both the pre-pubertal (0.7 (0.1) g/$ cm^{2} $vs 0.9 (0.1) g/$ cm^{2} $; P<0.001)) and peri-/post-pubertal groups (0.9 (0.1) g/$ cm^{2} $vs 1.1 (0.1) g/$ cm^{2} $; P<0.001). Also, the mean (SD) bone mineral apparent density of pre-pubertal and peri-/post-pubertal cystic fibrosis patients was lower than the controls (P<0.001 and P= 0.01, respectively). Thirty-seven (71.2%) cystic fibrosis patients had serum 25-hydroxyvitamin D level below 15 ng/mL. Conclusion Bone mineral density of children with cystic fibrosis was significantly lower than controls; majority of them were vitamin-D deficient. Intervening at an early stage of the disease and providing optimal therapy involving simultaneous management of the several factors affecting bone mineral accretion may be beneficial in improving bone health of these patients. Bone health (dpeaa)DE-He213 Chronic illness (dpeaa)DE-He213 Dual energy X-ray absorptiometry (dpeaa)DE-He213 Vitamin D (dpeaa)DE-He213 Mukherjee, Aparna aut Khadgawat, Rajesh aut Kabra, Madhulika aut Lodha, Rakesh aut Kabra, Sushil K. aut Enthalten in Indian Pediatrics Springer-Verlag, 2010 54(2017), 7 vom: Juli, Seite 545-549 (DE-627)SPR031274943 nnns volume:54 year:2017 number:7 month:07 pages:545-549 https://dx.doi.org/10.1007/s13312-017-1065-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_70 GBV_ILN_72 GBV_ILN_110 GBV_ILN_131 GBV_ILN_160 GBV_ILN_376 GBV_ILN_607 AR 54 2017 7 07 545-549 |
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10.1007/s13312-017-1065-7 doi (DE-627)SPR031293913 (SPR)s13312-017-1065-7-e DE-627 ger DE-627 rakwb eng Gupta, Sumita verfasserin aut Bone mineral density of Indian children and adolescents with cystic fibrosis 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Indian Academy of Pediatrics 2017 Objectives To document bone mineral density of children and adolescents with cystic fibrosis. Design Cross-sectional study. Setting Tertiary-care center of Northern India, July 2012 to August 2015. Participants 52 children aged 6-18 years with cystic fibrosis and 62 healthy controls of similar age and sex. Methods Both patients and controls were stratified into two groups, as pre-pubertal and peri-/post-pubertal, and compared for whole body bone mineral density, measured using dual energy X-ray absorptiometry. Serum levels of calcium, phosphate, alkaline phosphatase, 25-hydroxyvitamin D and parathyroid hormone were measured in children with cystic fibrosis. Results Compared with controls, the mean (SD) bone mineral density of children with cystic fibrosis was significantly lower in both the pre-pubertal (0.7 (0.1) g/$ cm^{2} $vs 0.9 (0.1) g/$ cm^{2} $; P<0.001)) and peri-/post-pubertal groups (0.9 (0.1) g/$ cm^{2} $vs 1.1 (0.1) g/$ cm^{2} $; P<0.001). Also, the mean (SD) bone mineral apparent density of pre-pubertal and peri-/post-pubertal cystic fibrosis patients was lower than the controls (P<0.001 and P= 0.01, respectively). Thirty-seven (71.2%) cystic fibrosis patients had serum 25-hydroxyvitamin D level below 15 ng/mL. Conclusion Bone mineral density of children with cystic fibrosis was significantly lower than controls; majority of them were vitamin-D deficient. Intervening at an early stage of the disease and providing optimal therapy involving simultaneous management of the several factors affecting bone mineral accretion may be beneficial in improving bone health of these patients. Bone health (dpeaa)DE-He213 Chronic illness (dpeaa)DE-He213 Dual energy X-ray absorptiometry (dpeaa)DE-He213 Vitamin D (dpeaa)DE-He213 Mukherjee, Aparna aut Khadgawat, Rajesh aut Kabra, Madhulika aut Lodha, Rakesh aut Kabra, Sushil K. aut Enthalten in Indian Pediatrics Springer-Verlag, 2010 54(2017), 7 vom: Juli, Seite 545-549 (DE-627)SPR031274943 nnns volume:54 year:2017 number:7 month:07 pages:545-549 https://dx.doi.org/10.1007/s13312-017-1065-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_70 GBV_ILN_72 GBV_ILN_110 GBV_ILN_131 GBV_ILN_160 GBV_ILN_376 GBV_ILN_607 AR 54 2017 7 07 545-549 |
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Design Cross-sectional study. Setting Tertiary-care center of Northern India, July 2012 to August 2015. Participants 52 children aged 6-18 years with cystic fibrosis and 62 healthy controls of similar age and sex. Methods Both patients and controls were stratified into two groups, as pre-pubertal and peri-/post-pubertal, and compared for whole body bone mineral density, measured using dual energy X-ray absorptiometry. Serum levels of calcium, phosphate, alkaline phosphatase, 25-hydroxyvitamin D and parathyroid hormone were measured in children with cystic fibrosis. Results Compared with controls, the mean (SD) bone mineral density of children with cystic fibrosis was significantly lower in both the pre-pubertal (0.7 (0.1) g/$ cm^{2} $vs 0.9 (0.1) g/$ cm^{2} $; P<0.001)) and peri-/post-pubertal groups (0.9 (0.1) g/$ cm^{2} $vs 1.1 (0.1) g/$ cm^{2} $; P<0.001). Also, the mean (SD) bone mineral apparent density of pre-pubertal and peri-/post-pubertal cystic fibrosis patients was lower than the controls (P<0.001 and P= 0.01, respectively). Thirty-seven (71.2%) cystic fibrosis patients had serum 25-hydroxyvitamin D level below 15 ng/mL. Conclusion Bone mineral density of children with cystic fibrosis was significantly lower than controls; majority of them were vitamin-D deficient. 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bone mineral density of indian children and adolescents with cystic fibrosis |
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Bone mineral density of Indian children and adolescents with cystic fibrosis |
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Objectives To document bone mineral density of children and adolescents with cystic fibrosis. Design Cross-sectional study. Setting Tertiary-care center of Northern India, July 2012 to August 2015. Participants 52 children aged 6-18 years with cystic fibrosis and 62 healthy controls of similar age and sex. Methods Both patients and controls were stratified into two groups, as pre-pubertal and peri-/post-pubertal, and compared for whole body bone mineral density, measured using dual energy X-ray absorptiometry. Serum levels of calcium, phosphate, alkaline phosphatase, 25-hydroxyvitamin D and parathyroid hormone were measured in children with cystic fibrosis. Results Compared with controls, the mean (SD) bone mineral density of children with cystic fibrosis was significantly lower in both the pre-pubertal (0.7 (0.1) g/$ cm^{2} $vs 0.9 (0.1) g/$ cm^{2} $; P<0.001)) and peri-/post-pubertal groups (0.9 (0.1) g/$ cm^{2} $vs 1.1 (0.1) g/$ cm^{2} $; P<0.001). Also, the mean (SD) bone mineral apparent density of pre-pubertal and peri-/post-pubertal cystic fibrosis patients was lower than the controls (P<0.001 and P= 0.01, respectively). Thirty-seven (71.2%) cystic fibrosis patients had serum 25-hydroxyvitamin D level below 15 ng/mL. Conclusion Bone mineral density of children with cystic fibrosis was significantly lower than controls; majority of them were vitamin-D deficient. Intervening at an early stage of the disease and providing optimal therapy involving simultaneous management of the several factors affecting bone mineral accretion may be beneficial in improving bone health of these patients. © Indian Academy of Pediatrics 2017 |
| abstractGer |
Objectives To document bone mineral density of children and adolescents with cystic fibrosis. Design Cross-sectional study. Setting Tertiary-care center of Northern India, July 2012 to August 2015. Participants 52 children aged 6-18 years with cystic fibrosis and 62 healthy controls of similar age and sex. Methods Both patients and controls were stratified into two groups, as pre-pubertal and peri-/post-pubertal, and compared for whole body bone mineral density, measured using dual energy X-ray absorptiometry. Serum levels of calcium, phosphate, alkaline phosphatase, 25-hydroxyvitamin D and parathyroid hormone were measured in children with cystic fibrosis. Results Compared with controls, the mean (SD) bone mineral density of children with cystic fibrosis was significantly lower in both the pre-pubertal (0.7 (0.1) g/$ cm^{2} $vs 0.9 (0.1) g/$ cm^{2} $; P<0.001)) and peri-/post-pubertal groups (0.9 (0.1) g/$ cm^{2} $vs 1.1 (0.1) g/$ cm^{2} $; P<0.001). Also, the mean (SD) bone mineral apparent density of pre-pubertal and peri-/post-pubertal cystic fibrosis patients was lower than the controls (P<0.001 and P= 0.01, respectively). Thirty-seven (71.2%) cystic fibrosis patients had serum 25-hydroxyvitamin D level below 15 ng/mL. Conclusion Bone mineral density of children with cystic fibrosis was significantly lower than controls; majority of them were vitamin-D deficient. Intervening at an early stage of the disease and providing optimal therapy involving simultaneous management of the several factors affecting bone mineral accretion may be beneficial in improving bone health of these patients. © Indian Academy of Pediatrics 2017 |
| abstract_unstemmed |
Objectives To document bone mineral density of children and adolescents with cystic fibrosis. Design Cross-sectional study. Setting Tertiary-care center of Northern India, July 2012 to August 2015. Participants 52 children aged 6-18 years with cystic fibrosis and 62 healthy controls of similar age and sex. Methods Both patients and controls were stratified into two groups, as pre-pubertal and peri-/post-pubertal, and compared for whole body bone mineral density, measured using dual energy X-ray absorptiometry. Serum levels of calcium, phosphate, alkaline phosphatase, 25-hydroxyvitamin D and parathyroid hormone were measured in children with cystic fibrosis. Results Compared with controls, the mean (SD) bone mineral density of children with cystic fibrosis was significantly lower in both the pre-pubertal (0.7 (0.1) g/$ cm^{2} $vs 0.9 (0.1) g/$ cm^{2} $; P<0.001)) and peri-/post-pubertal groups (0.9 (0.1) g/$ cm^{2} $vs 1.1 (0.1) g/$ cm^{2} $; P<0.001). Also, the mean (SD) bone mineral apparent density of pre-pubertal and peri-/post-pubertal cystic fibrosis patients was lower than the controls (P<0.001 and P= 0.01, respectively). Thirty-seven (71.2%) cystic fibrosis patients had serum 25-hydroxyvitamin D level below 15 ng/mL. Conclusion Bone mineral density of children with cystic fibrosis was significantly lower than controls; majority of them were vitamin-D deficient. Intervening at an early stage of the disease and providing optimal therapy involving simultaneous management of the several factors affecting bone mineral accretion may be beneficial in improving bone health of these patients. © Indian Academy of Pediatrics 2017 |
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