Second Dose of Scorpion Antivenom in Children with Indian Red Scorpion (Mesobuthus tamulus) Sting Envenomation
Objective To study the effect of the second dose of scorpion antivenom in children with nonresolving or worsening scorpion sting envenomation. Methods 72 children aged ≤12 years with scorpion sting envenomation grade 2 and above were enrolled. 61 received the first dose of three vials of antivenom a...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Abimannane, Anitha [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2018 |
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| Schlagwörter: |
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| Anmerkung: |
© Indian Academy of Pediatrics 2018 |
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| Übergeordnetes Werk: |
Enthalten in: Indian Pediatrics - Springer-Verlag, 2010, 55(2018), 4 vom: 09. Feb., Seite 315-318 |
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| Übergeordnetes Werk: |
volume:55 ; year:2018 ; number:4 ; day:09 ; month:02 ; pages:315-318 |
| Links: |
|---|
| DOI / URN: |
10.1007/s13312-018-1275-7 |
|---|
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SPR031296092 |
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| 520 | |a Objective To study the effect of the second dose of scorpion antivenom in children with nonresolving or worsening scorpion sting envenomation. Methods 72 children aged ≤12 years with scorpion sting envenomation grade 2 and above were enrolled. 61 received the first dose of three vials of antivenom at admission (group A). Children with persistent/worsening envenomation within 6 hours received the second dose (group B). The time required for resolution of autonomic symptoms, myocardial dysfunction, predictors of the second dose and side effects were studied. Results The mean time taken for resolution of autonomic symptoms were comparable in Group A and B (4.1 vs. 5.3 h, P=0.4), and of myocardial dysfunction was shorter in Group A (10.8 vs. 37.6 h, P=0.02). On regression analysis, abnormal echocardiography at admission was found to be a significant predictor of the second dose (OR=27.6, 95% CI, 4.7–162.5; P=<0.001). Conclusion Children with severe scorpion sting envenomation with abnormal echocardiography may require a higher dose of scorpion antivenom. Trial registration CTRI/2015/03/005652. | ||
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| 700 | 1 | |a Satheesh, Ponnarmeni |4 aut | |
| 700 | 1 | |a Mahadevan, Subramanian |4 aut | |
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10.1007/s13312-018-1275-7 doi (DE-627)SPR031296092 (SPR)s13312-018-1275-7-e DE-627 ger DE-627 rakwb eng Abimannane, Anitha verfasserin aut Second Dose of Scorpion Antivenom in Children with Indian Red Scorpion (Mesobuthus tamulus) Sting Envenomation 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Indian Academy of Pediatrics 2018 Objective To study the effect of the second dose of scorpion antivenom in children with nonresolving or worsening scorpion sting envenomation. Methods 72 children aged ≤12 years with scorpion sting envenomation grade 2 and above were enrolled. 61 received the first dose of three vials of antivenom at admission (group A). Children with persistent/worsening envenomation within 6 hours received the second dose (group B). The time required for resolution of autonomic symptoms, myocardial dysfunction, predictors of the second dose and side effects were studied. Results The mean time taken for resolution of autonomic symptoms were comparable in Group A and B (4.1 vs. 5.3 h, P=0.4), and of myocardial dysfunction was shorter in Group A (10.8 vs. 37.6 h, P=0.02). On regression analysis, abnormal echocardiography at admission was found to be a significant predictor of the second dose (OR=27.6, 95% CI, 4.7–162.5; P=<0.001). Conclusion Children with severe scorpion sting envenomation with abnormal echocardiography may require a higher dose of scorpion antivenom. Trial registration CTRI/2015/03/005652. Autonomic dysfunction (dpeaa)DE-He213 Myocardial dysfunction (dpeaa)DE-He213 Poisoning (dpeaa)DE-He213 Rameshkumar, Ramachandran aut Satheesh, Ponnarmeni aut Mahadevan, Subramanian aut Enthalten in Indian Pediatrics Springer-Verlag, 2010 55(2018), 4 vom: 09. Feb., Seite 315-318 (DE-627)SPR031274943 nnns volume:55 year:2018 number:4 day:09 month:02 pages:315-318 https://dx.doi.org/10.1007/s13312-018-1275-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_70 GBV_ILN_72 GBV_ILN_110 GBV_ILN_131 GBV_ILN_160 GBV_ILN_376 GBV_ILN_607 AR 55 2018 4 09 02 315-318 |
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10.1007/s13312-018-1275-7 doi (DE-627)SPR031296092 (SPR)s13312-018-1275-7-e DE-627 ger DE-627 rakwb eng Abimannane, Anitha verfasserin aut Second Dose of Scorpion Antivenom in Children with Indian Red Scorpion (Mesobuthus tamulus) Sting Envenomation 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Indian Academy of Pediatrics 2018 Objective To study the effect of the second dose of scorpion antivenom in children with nonresolving or worsening scorpion sting envenomation. Methods 72 children aged ≤12 years with scorpion sting envenomation grade 2 and above were enrolled. 61 received the first dose of three vials of antivenom at admission (group A). Children with persistent/worsening envenomation within 6 hours received the second dose (group B). The time required for resolution of autonomic symptoms, myocardial dysfunction, predictors of the second dose and side effects were studied. Results The mean time taken for resolution of autonomic symptoms were comparable in Group A and B (4.1 vs. 5.3 h, P=0.4), and of myocardial dysfunction was shorter in Group A (10.8 vs. 37.6 h, P=0.02). On regression analysis, abnormal echocardiography at admission was found to be a significant predictor of the second dose (OR=27.6, 95% CI, 4.7–162.5; P=<0.001). Conclusion Children with severe scorpion sting envenomation with abnormal echocardiography may require a higher dose of scorpion antivenom. Trial registration CTRI/2015/03/005652. Autonomic dysfunction (dpeaa)DE-He213 Myocardial dysfunction (dpeaa)DE-He213 Poisoning (dpeaa)DE-He213 Rameshkumar, Ramachandran aut Satheesh, Ponnarmeni aut Mahadevan, Subramanian aut Enthalten in Indian Pediatrics Springer-Verlag, 2010 55(2018), 4 vom: 09. Feb., Seite 315-318 (DE-627)SPR031274943 nnns volume:55 year:2018 number:4 day:09 month:02 pages:315-318 https://dx.doi.org/10.1007/s13312-018-1275-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_70 GBV_ILN_72 GBV_ILN_110 GBV_ILN_131 GBV_ILN_160 GBV_ILN_376 GBV_ILN_607 AR 55 2018 4 09 02 315-318 |
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10.1007/s13312-018-1275-7 doi (DE-627)SPR031296092 (SPR)s13312-018-1275-7-e DE-627 ger DE-627 rakwb eng Abimannane, Anitha verfasserin aut Second Dose of Scorpion Antivenom in Children with Indian Red Scorpion (Mesobuthus tamulus) Sting Envenomation 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Indian Academy of Pediatrics 2018 Objective To study the effect of the second dose of scorpion antivenom in children with nonresolving or worsening scorpion sting envenomation. Methods 72 children aged ≤12 years with scorpion sting envenomation grade 2 and above were enrolled. 61 received the first dose of three vials of antivenom at admission (group A). Children with persistent/worsening envenomation within 6 hours received the second dose (group B). The time required for resolution of autonomic symptoms, myocardial dysfunction, predictors of the second dose and side effects were studied. Results The mean time taken for resolution of autonomic symptoms were comparable in Group A and B (4.1 vs. 5.3 h, P=0.4), and of myocardial dysfunction was shorter in Group A (10.8 vs. 37.6 h, P=0.02). On regression analysis, abnormal echocardiography at admission was found to be a significant predictor of the second dose (OR=27.6, 95% CI, 4.7–162.5; P=<0.001). Conclusion Children with severe scorpion sting envenomation with abnormal echocardiography may require a higher dose of scorpion antivenom. Trial registration CTRI/2015/03/005652. Autonomic dysfunction (dpeaa)DE-He213 Myocardial dysfunction (dpeaa)DE-He213 Poisoning (dpeaa)DE-He213 Rameshkumar, Ramachandran aut Satheesh, Ponnarmeni aut Mahadevan, Subramanian aut Enthalten in Indian Pediatrics Springer-Verlag, 2010 55(2018), 4 vom: 09. Feb., Seite 315-318 (DE-627)SPR031274943 nnns volume:55 year:2018 number:4 day:09 month:02 pages:315-318 https://dx.doi.org/10.1007/s13312-018-1275-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_70 GBV_ILN_72 GBV_ILN_110 GBV_ILN_131 GBV_ILN_160 GBV_ILN_376 GBV_ILN_607 AR 55 2018 4 09 02 315-318 |
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10.1007/s13312-018-1275-7 doi (DE-627)SPR031296092 (SPR)s13312-018-1275-7-e DE-627 ger DE-627 rakwb eng Abimannane, Anitha verfasserin aut Second Dose of Scorpion Antivenom in Children with Indian Red Scorpion (Mesobuthus tamulus) Sting Envenomation 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Indian Academy of Pediatrics 2018 Objective To study the effect of the second dose of scorpion antivenom in children with nonresolving or worsening scorpion sting envenomation. Methods 72 children aged ≤12 years with scorpion sting envenomation grade 2 and above were enrolled. 61 received the first dose of three vials of antivenom at admission (group A). Children with persistent/worsening envenomation within 6 hours received the second dose (group B). The time required for resolution of autonomic symptoms, myocardial dysfunction, predictors of the second dose and side effects were studied. Results The mean time taken for resolution of autonomic symptoms were comparable in Group A and B (4.1 vs. 5.3 h, P=0.4), and of myocardial dysfunction was shorter in Group A (10.8 vs. 37.6 h, P=0.02). On regression analysis, abnormal echocardiography at admission was found to be a significant predictor of the second dose (OR=27.6, 95% CI, 4.7–162.5; P=<0.001). Conclusion Children with severe scorpion sting envenomation with abnormal echocardiography may require a higher dose of scorpion antivenom. Trial registration CTRI/2015/03/005652. Autonomic dysfunction (dpeaa)DE-He213 Myocardial dysfunction (dpeaa)DE-He213 Poisoning (dpeaa)DE-He213 Rameshkumar, Ramachandran aut Satheesh, Ponnarmeni aut Mahadevan, Subramanian aut Enthalten in Indian Pediatrics Springer-Verlag, 2010 55(2018), 4 vom: 09. Feb., Seite 315-318 (DE-627)SPR031274943 nnns volume:55 year:2018 number:4 day:09 month:02 pages:315-318 https://dx.doi.org/10.1007/s13312-018-1275-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_70 GBV_ILN_72 GBV_ILN_110 GBV_ILN_131 GBV_ILN_160 GBV_ILN_376 GBV_ILN_607 AR 55 2018 4 09 02 315-318 |
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10.1007/s13312-018-1275-7 doi (DE-627)SPR031296092 (SPR)s13312-018-1275-7-e DE-627 ger DE-627 rakwb eng Abimannane, Anitha verfasserin aut Second Dose of Scorpion Antivenom in Children with Indian Red Scorpion (Mesobuthus tamulus) Sting Envenomation 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Indian Academy of Pediatrics 2018 Objective To study the effect of the second dose of scorpion antivenom in children with nonresolving or worsening scorpion sting envenomation. Methods 72 children aged ≤12 years with scorpion sting envenomation grade 2 and above were enrolled. 61 received the first dose of three vials of antivenom at admission (group A). Children with persistent/worsening envenomation within 6 hours received the second dose (group B). The time required for resolution of autonomic symptoms, myocardial dysfunction, predictors of the second dose and side effects were studied. Results The mean time taken for resolution of autonomic symptoms were comparable in Group A and B (4.1 vs. 5.3 h, P=0.4), and of myocardial dysfunction was shorter in Group A (10.8 vs. 37.6 h, P=0.02). On regression analysis, abnormal echocardiography at admission was found to be a significant predictor of the second dose (OR=27.6, 95% CI, 4.7–162.5; P=<0.001). Conclusion Children with severe scorpion sting envenomation with abnormal echocardiography may require a higher dose of scorpion antivenom. Trial registration CTRI/2015/03/005652. Autonomic dysfunction (dpeaa)DE-He213 Myocardial dysfunction (dpeaa)DE-He213 Poisoning (dpeaa)DE-He213 Rameshkumar, Ramachandran aut Satheesh, Ponnarmeni aut Mahadevan, Subramanian aut Enthalten in Indian Pediatrics Springer-Verlag, 2010 55(2018), 4 vom: 09. Feb., Seite 315-318 (DE-627)SPR031274943 nnns volume:55 year:2018 number:4 day:09 month:02 pages:315-318 https://dx.doi.org/10.1007/s13312-018-1275-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_70 GBV_ILN_72 GBV_ILN_110 GBV_ILN_131 GBV_ILN_160 GBV_ILN_376 GBV_ILN_607 AR 55 2018 4 09 02 315-318 |
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Abimannane, Anitha Rameshkumar, Ramachandran Satheesh, Ponnarmeni Mahadevan, Subramanian |
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Abimannane, Anitha |
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10.1007/s13312-018-1275-7 |
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second dose of scorpion antivenom in children with indian red scorpion (mesobuthus tamulus) sting envenomation |
| title_auth |
Second Dose of Scorpion Antivenom in Children with Indian Red Scorpion (Mesobuthus tamulus) Sting Envenomation |
| abstract |
Objective To study the effect of the second dose of scorpion antivenom in children with nonresolving or worsening scorpion sting envenomation. Methods 72 children aged ≤12 years with scorpion sting envenomation grade 2 and above were enrolled. 61 received the first dose of three vials of antivenom at admission (group A). Children with persistent/worsening envenomation within 6 hours received the second dose (group B). The time required for resolution of autonomic symptoms, myocardial dysfunction, predictors of the second dose and side effects were studied. Results The mean time taken for resolution of autonomic symptoms were comparable in Group A and B (4.1 vs. 5.3 h, P=0.4), and of myocardial dysfunction was shorter in Group A (10.8 vs. 37.6 h, P=0.02). On regression analysis, abnormal echocardiography at admission was found to be a significant predictor of the second dose (OR=27.6, 95% CI, 4.7–162.5; P=<0.001). Conclusion Children with severe scorpion sting envenomation with abnormal echocardiography may require a higher dose of scorpion antivenom. Trial registration CTRI/2015/03/005652. © Indian Academy of Pediatrics 2018 |
| abstractGer |
Objective To study the effect of the second dose of scorpion antivenom in children with nonresolving or worsening scorpion sting envenomation. Methods 72 children aged ≤12 years with scorpion sting envenomation grade 2 and above were enrolled. 61 received the first dose of three vials of antivenom at admission (group A). Children with persistent/worsening envenomation within 6 hours received the second dose (group B). The time required for resolution of autonomic symptoms, myocardial dysfunction, predictors of the second dose and side effects were studied. Results The mean time taken for resolution of autonomic symptoms were comparable in Group A and B (4.1 vs. 5.3 h, P=0.4), and of myocardial dysfunction was shorter in Group A (10.8 vs. 37.6 h, P=0.02). On regression analysis, abnormal echocardiography at admission was found to be a significant predictor of the second dose (OR=27.6, 95% CI, 4.7–162.5; P=<0.001). Conclusion Children with severe scorpion sting envenomation with abnormal echocardiography may require a higher dose of scorpion antivenom. Trial registration CTRI/2015/03/005652. © Indian Academy of Pediatrics 2018 |
| abstract_unstemmed |
Objective To study the effect of the second dose of scorpion antivenom in children with nonresolving or worsening scorpion sting envenomation. Methods 72 children aged ≤12 years with scorpion sting envenomation grade 2 and above were enrolled. 61 received the first dose of three vials of antivenom at admission (group A). Children with persistent/worsening envenomation within 6 hours received the second dose (group B). The time required for resolution of autonomic symptoms, myocardial dysfunction, predictors of the second dose and side effects were studied. Results The mean time taken for resolution of autonomic symptoms were comparable in Group A and B (4.1 vs. 5.3 h, P=0.4), and of myocardial dysfunction was shorter in Group A (10.8 vs. 37.6 h, P=0.02). On regression analysis, abnormal echocardiography at admission was found to be a significant predictor of the second dose (OR=27.6, 95% CI, 4.7–162.5; P=<0.001). Conclusion Children with severe scorpion sting envenomation with abnormal echocardiography may require a higher dose of scorpion antivenom. Trial registration CTRI/2015/03/005652. © Indian Academy of Pediatrics 2018 |
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| title_short |
Second Dose of Scorpion Antivenom in Children with Indian Red Scorpion (Mesobuthus tamulus) Sting Envenomation |
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