Localization and functions of mesenchymal stromal cells in vivo
Abstract The study of mesenchymal stromal cells (MSCs) is a very topical problem. Numerous experiments in vitro advanced the understanding of MSC biology to a great extent. However, many aspects of their behavior in vivo still remain unclear. This review deals with MSC localization and functioning i...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Payushina, O. V. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016 |
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| Schlagwörter: |
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| Anmerkung: |
© Pleiades Publishing, Ltd. 2016 |
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| Übergeordnetes Werk: |
Enthalten in: Biology bulletin reviews - Moscow : MAIK Nauka/Interperiodica Publ., 2011, 6(2016), 1 vom: Jan., Seite 1-10 |
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| Übergeordnetes Werk: |
volume:6 ; year:2016 ; number:1 ; month:01 ; pages:1-10 |
| Links: |
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| DOI / URN: |
10.1134/S2079086416010059 |
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| Katalog-ID: |
SPR031376150 |
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| 520 | |a Abstract The study of mesenchymal stromal cells (MSCs) is a very topical problem. Numerous experiments in vitro advanced the understanding of MSC biology to a great extent. However, many aspects of their behavior in vivo still remain unclear. This review deals with MSC localization and functioning in an organism. MSCs are present in various tissues, changing their numbers and traits during ontogenesis. Pericytes, or adventitial cells, can be considered possible equivalents of MSCs in vivo. Self-maintenance, proliferation, and differentiation of MSCs are controlled by their tissue microenvironment, which includes the surrounding cells, soluble molecules, and extracellular matrix. At early stages of ontogenesis, MSCs probably migrate throughout an organism and populate various tissues. The migration occurs also through a mature organism when tissues happen to be damaged. MSCs move pointedly to the damaged parts and render a reparative effect that is due primarily to the paracrine production of bioactive molecules and immunomodulatory properties of MSCs rather than their differentiation. An important function of MSCs is the creation of hematopoietic microenvironment by the secretion of cytokines and chemoattractants, as well as by direct interaction with hemopoietic cells. It is possible that MSCs sustain the stable functioning of not only hematopoietic but also other tissues. Their unique features make them quite attractive for clinical use, although the successful introduction of MSC into medical practice requires further study of their interaction with the recipient organism and their effect on regeneration. | ||
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10.1134/S2079086416010059 doi (DE-627)SPR031376150 (SPR)S2079086416010059-e DE-627 ger DE-627 rakwb eng Payushina, O. V. verfasserin aut Localization and functions of mesenchymal stromal cells in vivo 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Pleiades Publishing, Ltd. 2016 Abstract The study of mesenchymal stromal cells (MSCs) is a very topical problem. Numerous experiments in vitro advanced the understanding of MSC biology to a great extent. However, many aspects of their behavior in vivo still remain unclear. This review deals with MSC localization and functioning in an organism. MSCs are present in various tissues, changing their numbers and traits during ontogenesis. Pericytes, or adventitial cells, can be considered possible equivalents of MSCs in vivo. Self-maintenance, proliferation, and differentiation of MSCs are controlled by their tissue microenvironment, which includes the surrounding cells, soluble molecules, and extracellular matrix. At early stages of ontogenesis, MSCs probably migrate throughout an organism and populate various tissues. The migration occurs also through a mature organism when tissues happen to be damaged. MSCs move pointedly to the damaged parts and render a reparative effect that is due primarily to the paracrine production of bioactive molecules and immunomodulatory properties of MSCs rather than their differentiation. An important function of MSCs is the creation of hematopoietic microenvironment by the secretion of cytokines and chemoattractants, as well as by direct interaction with hemopoietic cells. It is possible that MSCs sustain the stable functioning of not only hematopoietic but also other tissues. Their unique features make them quite attractive for clinical use, although the successful introduction of MSC into medical practice requires further study of their interaction with the recipient organism and their effect on regeneration. Stem Cell (dpeaa)DE-He213 Mesenchymal Stem Cell (dpeaa)DE-He213 Mesenchymal Stromal Cell (dpeaa)DE-He213 Bone Marrow Stromal Cell (dpeaa)DE-He213 Human Mesenchymal Stem Cell (dpeaa)DE-He213 Enthalten in Biology bulletin reviews Moscow : MAIK Nauka/Interperiodica Publ., 2011 6(2016), 1 vom: Jan., Seite 1-10 (DE-627)647307227 (DE-600)2595495-7 2079-0872 nnns volume:6 year:2016 number:1 month:01 pages:1-10 https://dx.doi.org/10.1134/S2079086416010059 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 6 2016 1 01 1-10 |
| spelling |
10.1134/S2079086416010059 doi (DE-627)SPR031376150 (SPR)S2079086416010059-e DE-627 ger DE-627 rakwb eng Payushina, O. V. verfasserin aut Localization and functions of mesenchymal stromal cells in vivo 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Pleiades Publishing, Ltd. 2016 Abstract The study of mesenchymal stromal cells (MSCs) is a very topical problem. Numerous experiments in vitro advanced the understanding of MSC biology to a great extent. However, many aspects of their behavior in vivo still remain unclear. This review deals with MSC localization and functioning in an organism. MSCs are present in various tissues, changing their numbers and traits during ontogenesis. Pericytes, or adventitial cells, can be considered possible equivalents of MSCs in vivo. Self-maintenance, proliferation, and differentiation of MSCs are controlled by their tissue microenvironment, which includes the surrounding cells, soluble molecules, and extracellular matrix. At early stages of ontogenesis, MSCs probably migrate throughout an organism and populate various tissues. The migration occurs also through a mature organism when tissues happen to be damaged. MSCs move pointedly to the damaged parts and render a reparative effect that is due primarily to the paracrine production of bioactive molecules and immunomodulatory properties of MSCs rather than their differentiation. An important function of MSCs is the creation of hematopoietic microenvironment by the secretion of cytokines and chemoattractants, as well as by direct interaction with hemopoietic cells. It is possible that MSCs sustain the stable functioning of not only hematopoietic but also other tissues. Their unique features make them quite attractive for clinical use, although the successful introduction of MSC into medical practice requires further study of their interaction with the recipient organism and their effect on regeneration. Stem Cell (dpeaa)DE-He213 Mesenchymal Stem Cell (dpeaa)DE-He213 Mesenchymal Stromal Cell (dpeaa)DE-He213 Bone Marrow Stromal Cell (dpeaa)DE-He213 Human Mesenchymal Stem Cell (dpeaa)DE-He213 Enthalten in Biology bulletin reviews Moscow : MAIK Nauka/Interperiodica Publ., 2011 6(2016), 1 vom: Jan., Seite 1-10 (DE-627)647307227 (DE-600)2595495-7 2079-0872 nnns volume:6 year:2016 number:1 month:01 pages:1-10 https://dx.doi.org/10.1134/S2079086416010059 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 6 2016 1 01 1-10 |
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10.1134/S2079086416010059 doi (DE-627)SPR031376150 (SPR)S2079086416010059-e DE-627 ger DE-627 rakwb eng Payushina, O. V. verfasserin aut Localization and functions of mesenchymal stromal cells in vivo 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Pleiades Publishing, Ltd. 2016 Abstract The study of mesenchymal stromal cells (MSCs) is a very topical problem. Numerous experiments in vitro advanced the understanding of MSC biology to a great extent. However, many aspects of their behavior in vivo still remain unclear. This review deals with MSC localization and functioning in an organism. MSCs are present in various tissues, changing their numbers and traits during ontogenesis. Pericytes, or adventitial cells, can be considered possible equivalents of MSCs in vivo. Self-maintenance, proliferation, and differentiation of MSCs are controlled by their tissue microenvironment, which includes the surrounding cells, soluble molecules, and extracellular matrix. At early stages of ontogenesis, MSCs probably migrate throughout an organism and populate various tissues. The migration occurs also through a mature organism when tissues happen to be damaged. MSCs move pointedly to the damaged parts and render a reparative effect that is due primarily to the paracrine production of bioactive molecules and immunomodulatory properties of MSCs rather than their differentiation. An important function of MSCs is the creation of hematopoietic microenvironment by the secretion of cytokines and chemoattractants, as well as by direct interaction with hemopoietic cells. It is possible that MSCs sustain the stable functioning of not only hematopoietic but also other tissues. Their unique features make them quite attractive for clinical use, although the successful introduction of MSC into medical practice requires further study of their interaction with the recipient organism and their effect on regeneration. Stem Cell (dpeaa)DE-He213 Mesenchymal Stem Cell (dpeaa)DE-He213 Mesenchymal Stromal Cell (dpeaa)DE-He213 Bone Marrow Stromal Cell (dpeaa)DE-He213 Human Mesenchymal Stem Cell (dpeaa)DE-He213 Enthalten in Biology bulletin reviews Moscow : MAIK Nauka/Interperiodica Publ., 2011 6(2016), 1 vom: Jan., Seite 1-10 (DE-627)647307227 (DE-600)2595495-7 2079-0872 nnns volume:6 year:2016 number:1 month:01 pages:1-10 https://dx.doi.org/10.1134/S2079086416010059 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 6 2016 1 01 1-10 |
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10.1134/S2079086416010059 doi (DE-627)SPR031376150 (SPR)S2079086416010059-e DE-627 ger DE-627 rakwb eng Payushina, O. V. verfasserin aut Localization and functions of mesenchymal stromal cells in vivo 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Pleiades Publishing, Ltd. 2016 Abstract The study of mesenchymal stromal cells (MSCs) is a very topical problem. Numerous experiments in vitro advanced the understanding of MSC biology to a great extent. However, many aspects of their behavior in vivo still remain unclear. This review deals with MSC localization and functioning in an organism. MSCs are present in various tissues, changing their numbers and traits during ontogenesis. Pericytes, or adventitial cells, can be considered possible equivalents of MSCs in vivo. Self-maintenance, proliferation, and differentiation of MSCs are controlled by their tissue microenvironment, which includes the surrounding cells, soluble molecules, and extracellular matrix. At early stages of ontogenesis, MSCs probably migrate throughout an organism and populate various tissues. The migration occurs also through a mature organism when tissues happen to be damaged. MSCs move pointedly to the damaged parts and render a reparative effect that is due primarily to the paracrine production of bioactive molecules and immunomodulatory properties of MSCs rather than their differentiation. An important function of MSCs is the creation of hematopoietic microenvironment by the secretion of cytokines and chemoattractants, as well as by direct interaction with hemopoietic cells. It is possible that MSCs sustain the stable functioning of not only hematopoietic but also other tissues. Their unique features make them quite attractive for clinical use, although the successful introduction of MSC into medical practice requires further study of their interaction with the recipient organism and their effect on regeneration. Stem Cell (dpeaa)DE-He213 Mesenchymal Stem Cell (dpeaa)DE-He213 Mesenchymal Stromal Cell (dpeaa)DE-He213 Bone Marrow Stromal Cell (dpeaa)DE-He213 Human Mesenchymal Stem Cell (dpeaa)DE-He213 Enthalten in Biology bulletin reviews Moscow : MAIK Nauka/Interperiodica Publ., 2011 6(2016), 1 vom: Jan., Seite 1-10 (DE-627)647307227 (DE-600)2595495-7 2079-0872 nnns volume:6 year:2016 number:1 month:01 pages:1-10 https://dx.doi.org/10.1134/S2079086416010059 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 6 2016 1 01 1-10 |
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10.1134/S2079086416010059 doi (DE-627)SPR031376150 (SPR)S2079086416010059-e DE-627 ger DE-627 rakwb eng Payushina, O. V. verfasserin aut Localization and functions of mesenchymal stromal cells in vivo 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Pleiades Publishing, Ltd. 2016 Abstract The study of mesenchymal stromal cells (MSCs) is a very topical problem. Numerous experiments in vitro advanced the understanding of MSC biology to a great extent. However, many aspects of their behavior in vivo still remain unclear. This review deals with MSC localization and functioning in an organism. MSCs are present in various tissues, changing their numbers and traits during ontogenesis. Pericytes, or adventitial cells, can be considered possible equivalents of MSCs in vivo. Self-maintenance, proliferation, and differentiation of MSCs are controlled by their tissue microenvironment, which includes the surrounding cells, soluble molecules, and extracellular matrix. At early stages of ontogenesis, MSCs probably migrate throughout an organism and populate various tissues. The migration occurs also through a mature organism when tissues happen to be damaged. MSCs move pointedly to the damaged parts and render a reparative effect that is due primarily to the paracrine production of bioactive molecules and immunomodulatory properties of MSCs rather than their differentiation. An important function of MSCs is the creation of hematopoietic microenvironment by the secretion of cytokines and chemoattractants, as well as by direct interaction with hemopoietic cells. It is possible that MSCs sustain the stable functioning of not only hematopoietic but also other tissues. Their unique features make them quite attractive for clinical use, although the successful introduction of MSC into medical practice requires further study of their interaction with the recipient organism and their effect on regeneration. Stem Cell (dpeaa)DE-He213 Mesenchymal Stem Cell (dpeaa)DE-He213 Mesenchymal Stromal Cell (dpeaa)DE-He213 Bone Marrow Stromal Cell (dpeaa)DE-He213 Human Mesenchymal Stem Cell (dpeaa)DE-He213 Enthalten in Biology bulletin reviews Moscow : MAIK Nauka/Interperiodica Publ., 2011 6(2016), 1 vom: Jan., Seite 1-10 (DE-627)647307227 (DE-600)2595495-7 2079-0872 nnns volume:6 year:2016 number:1 month:01 pages:1-10 https://dx.doi.org/10.1134/S2079086416010059 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 6 2016 1 01 1-10 |
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Payushina, O. V. |
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Localization and functions of mesenchymal stromal cells in vivo Stem Cell (dpeaa)DE-He213 Mesenchymal Stem Cell (dpeaa)DE-He213 Mesenchymal Stromal Cell (dpeaa)DE-He213 Bone Marrow Stromal Cell (dpeaa)DE-He213 Human Mesenchymal Stem Cell (dpeaa)DE-He213 |
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localization and functions of mesenchymal stromal cells in vivo |
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Localization and functions of mesenchymal stromal cells in vivo |
| abstract |
Abstract The study of mesenchymal stromal cells (MSCs) is a very topical problem. Numerous experiments in vitro advanced the understanding of MSC biology to a great extent. However, many aspects of their behavior in vivo still remain unclear. This review deals with MSC localization and functioning in an organism. MSCs are present in various tissues, changing their numbers and traits during ontogenesis. Pericytes, or adventitial cells, can be considered possible equivalents of MSCs in vivo. Self-maintenance, proliferation, and differentiation of MSCs are controlled by their tissue microenvironment, which includes the surrounding cells, soluble molecules, and extracellular matrix. At early stages of ontogenesis, MSCs probably migrate throughout an organism and populate various tissues. The migration occurs also through a mature organism when tissues happen to be damaged. MSCs move pointedly to the damaged parts and render a reparative effect that is due primarily to the paracrine production of bioactive molecules and immunomodulatory properties of MSCs rather than their differentiation. An important function of MSCs is the creation of hematopoietic microenvironment by the secretion of cytokines and chemoattractants, as well as by direct interaction with hemopoietic cells. It is possible that MSCs sustain the stable functioning of not only hematopoietic but also other tissues. Their unique features make them quite attractive for clinical use, although the successful introduction of MSC into medical practice requires further study of their interaction with the recipient organism and their effect on regeneration. © Pleiades Publishing, Ltd. 2016 |
| abstractGer |
Abstract The study of mesenchymal stromal cells (MSCs) is a very topical problem. Numerous experiments in vitro advanced the understanding of MSC biology to a great extent. However, many aspects of their behavior in vivo still remain unclear. This review deals with MSC localization and functioning in an organism. MSCs are present in various tissues, changing their numbers and traits during ontogenesis. Pericytes, or adventitial cells, can be considered possible equivalents of MSCs in vivo. Self-maintenance, proliferation, and differentiation of MSCs are controlled by their tissue microenvironment, which includes the surrounding cells, soluble molecules, and extracellular matrix. At early stages of ontogenesis, MSCs probably migrate throughout an organism and populate various tissues. The migration occurs also through a mature organism when tissues happen to be damaged. MSCs move pointedly to the damaged parts and render a reparative effect that is due primarily to the paracrine production of bioactive molecules and immunomodulatory properties of MSCs rather than their differentiation. An important function of MSCs is the creation of hematopoietic microenvironment by the secretion of cytokines and chemoattractants, as well as by direct interaction with hemopoietic cells. It is possible that MSCs sustain the stable functioning of not only hematopoietic but also other tissues. Their unique features make them quite attractive for clinical use, although the successful introduction of MSC into medical practice requires further study of their interaction with the recipient organism and their effect on regeneration. © Pleiades Publishing, Ltd. 2016 |
| abstract_unstemmed |
Abstract The study of mesenchymal stromal cells (MSCs) is a very topical problem. Numerous experiments in vitro advanced the understanding of MSC biology to a great extent. However, many aspects of their behavior in vivo still remain unclear. This review deals with MSC localization and functioning in an organism. MSCs are present in various tissues, changing their numbers and traits during ontogenesis. Pericytes, or adventitial cells, can be considered possible equivalents of MSCs in vivo. Self-maintenance, proliferation, and differentiation of MSCs are controlled by their tissue microenvironment, which includes the surrounding cells, soluble molecules, and extracellular matrix. At early stages of ontogenesis, MSCs probably migrate throughout an organism and populate various tissues. The migration occurs also through a mature organism when tissues happen to be damaged. MSCs move pointedly to the damaged parts and render a reparative effect that is due primarily to the paracrine production of bioactive molecules and immunomodulatory properties of MSCs rather than their differentiation. An important function of MSCs is the creation of hematopoietic microenvironment by the secretion of cytokines and chemoattractants, as well as by direct interaction with hemopoietic cells. It is possible that MSCs sustain the stable functioning of not only hematopoietic but also other tissues. Their unique features make them quite attractive for clinical use, although the successful introduction of MSC into medical practice requires further study of their interaction with the recipient organism and their effect on regeneration. © Pleiades Publishing, Ltd. 2016 |
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| title_short |
Localization and functions of mesenchymal stromal cells in vivo |
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https://dx.doi.org/10.1134/S2079086416010059 |
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2024-07-03T23:25:57.877Z |
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