In vivo and in vitro antidiabetic effects of citrus flavonoids; a study on the mechanism of action

Abstract Type 2 diabetes mellitus is a result of hyperglycemia caused by overproduction of glucose at the hepatic level or because of abnormal β cell function or insulin resistance at target cells. The purpose of this study was to investigate the hypoglycemic effect of hesperidin and naringin and to...
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Autor*in:	Mahmoud, Ayman M. [verfasserIn] Ahmed, Osama M. [verfasserIn] Ashour, Mohamed B. [verfasserIn] Abdel-Moneim, Adel [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Citrus flavonoids Hesperidin Naringin GLUT4 Insulin release HFD/STZ diabetes

Übergeordnetes Werk:	Enthalten in: International journal of diabetes in developing countries - [Delhi] : Springer India, 2006, 35(2015), 3 vom: 19. Jan., Seite 250-263
Übergeordnetes Werk:	volume:35 ; year:2015 ; number:3 ; day:19 ; month:01 ; pages:250-263

Links:	Volltext

DOI / URN:	10.1007/s13410-014-0268-x

Katalog-ID:	SPR031602193

Internformat


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520			\|a Abstract Type 2 diabetes mellitus is a result of hyperglycemia caused by overproduction of glucose at the hepatic level or because of abnormal β cell function or insulin resistance at target cells. The purpose of this study was to investigate the hypoglycemic effect of hesperidin and naringin and to suggest their probable mechanisms of action in high fat-fed/streptozotocin (STZ)-induced type 2 diabetic rats. Male albino rats were divided into four groups. Group 1 was normal control, and others were induced with diabetes by feeding a high-fat diet for 2 weeks followed by an intraperitoneal injection of streptozotocin (35 mg/kg b.wt.). Group 2 was kept as diabetic control, and groups 3 and 4 were further treated with an oral dose of 50 mg/kg hesperidin and naringin. In the diabetic control group, levels of glucose and glycosylated hemoglobin were significantly increased, while serum insulin level and hepatic and muscle glycogen were decreased. Both hesperidin and naringin supplementation significantly reversed these parameters. The activity of the hepatic key enzyme hexokinase was significantly increased whereas, glucose-6-phosphatase, glycogen phosphorylase, and fructose-1,6-bisphosphatase activities were significantly decreased as a result of treatment. Furthermore, both compounds were found to decrease intestinal glucose absorption in situ and to increase insulin release from isolated islets, peripheral glucose uptake in vitro, and adipose tissue glucose transporter type 4 (GLUT4) messenger RNA (mRNA) and protein expressions. These results showed that hesperidin and naringin have potent antihyperglycemic activity in high fat-fed/STZ-induced diabetic rats.
650		4	\|a Citrus flavonoids \|7 (dpeaa)DE-He213
650		4	\|a Hesperidin \|7 (dpeaa)DE-He213
650		4	\|a Naringin \|7 (dpeaa)DE-He213
650		4	\|a GLUT4 \|7 (dpeaa)DE-He213
650		4	\|a Insulin release \|7 (dpeaa)DE-He213
650		4	\|a HFD/STZ diabetes \|7 (dpeaa)DE-He213
700	1		\|a Ahmed, Osama M. \|e verfasserin \|4 aut
700	1		\|a Ashour, Mohamed B. \|e verfasserin \|4 aut
700	1		\|a Abdel-Moneim, Adel \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t International journal of diabetes in developing countries \|d [Delhi] : Springer India, 2006 \|g 35(2015), 3 vom: 19. Jan., Seite 250-263 \|w (DE-627)521483700 \|w (DE-600)2263351-0 \|x 1998-3832 \|7 nnns
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912			\|a GBV_ILN_24
912			\|a GBV_ILN_31
912			\|a GBV_ILN_32
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_90
912			\|a GBV_ILN_95
912			\|a GBV_ILN_100
912			\|a GBV_ILN_101
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_120
912			\|a GBV_ILN_138
912			\|a GBV_ILN_150
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_171
912			\|a GBV_ILN_187
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_250
912			\|a GBV_ILN_281
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_636
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
912			\|a GBV_ILN_2007
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2026
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2031
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2037
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2039
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2057
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2070
912			\|a GBV_ILN_2086
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2093
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2107
912			\|a GBV_ILN_2108
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2116
912			\|a GBV_ILN_2118
912			\|a GBV_ILN_2119
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2144
912			\|a GBV_ILN_2147
912			\|a GBV_ILN_2148
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2188
912			\|a GBV_ILN_2232
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2446
912			\|a GBV_ILN_2470
912			\|a GBV_ILN_2472
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_2522
912			\|a GBV_ILN_2548
912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4046
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4246
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4336
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 35 \|j 2015 \|e 3 \|b 19 \|c 01 \|h 250-263

Indexfelder

author_variant	a m m am amm o m a om oma m b a mb mba a a m aam
matchkey_str	article:19983832:2015----::nionivtoniibtcfetoctufaoodatdo
hierarchy_sort_str	2015
publishDate	2015
allfields	10.1007/s13410-014-0268-x doi (DE-627)SPR031602193 (SPR)s13410-014-0268-x-e DE-627 ger DE-627 rakwb eng 610 ASE Mahmoud, Ayman M. verfasserin aut In vivo and in vitro antidiabetic effects of citrus flavonoids; a study on the mechanism of action 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Type 2 diabetes mellitus is a result of hyperglycemia caused by overproduction of glucose at the hepatic level or because of abnormal β cell function or insulin resistance at target cells. The purpose of this study was to investigate the hypoglycemic effect of hesperidin and naringin and to suggest their probable mechanisms of action in high fat-fed/streptozotocin (STZ)-induced type 2 diabetic rats. Male albino rats were divided into four groups. Group 1 was normal control, and others were induced with diabetes by feeding a high-fat diet for 2 weeks followed by an intraperitoneal injection of streptozotocin (35 mg/kg b.wt.). Group 2 was kept as diabetic control, and groups 3 and 4 were further treated with an oral dose of 50 mg/kg hesperidin and naringin. In the diabetic control group, levels of glucose and glycosylated hemoglobin were significantly increased, while serum insulin level and hepatic and muscle glycogen were decreased. Both hesperidin and naringin supplementation significantly reversed these parameters. The activity of the hepatic key enzyme hexokinase was significantly increased whereas, glucose-6-phosphatase, glycogen phosphorylase, and fructose-1,6-bisphosphatase activities were significantly decreased as a result of treatment. Furthermore, both compounds were found to decrease intestinal glucose absorption in situ and to increase insulin release from isolated islets, peripheral glucose uptake in vitro, and adipose tissue glucose transporter type 4 (GLUT4) messenger RNA (mRNA) and protein expressions. These results showed that hesperidin and naringin have potent antihyperglycemic activity in high fat-fed/STZ-induced diabetic rats. Citrus flavonoids (dpeaa)DE-He213 Hesperidin (dpeaa)DE-He213 Naringin (dpeaa)DE-He213 GLUT4 (dpeaa)DE-He213 Insulin release (dpeaa)DE-He213 HFD/STZ diabetes (dpeaa)DE-He213 Ahmed, Osama M. verfasserin aut Ashour, Mohamed B. verfasserin aut Abdel-Moneim, Adel verfasserin aut Enthalten in International journal of diabetes in developing countries [Delhi] : Springer India, 2006 35(2015), 3 vom: 19. Jan., Seite 250-263 (DE-627)521483700 (DE-600)2263351-0 1998-3832 nnns volume:35 year:2015 number:3 day:19 month:01 pages:250-263 https://dx.doi.org/10.1007/s13410-014-0268-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 35 2015 3 19 01 250-263
spelling	10.1007/s13410-014-0268-x doi (DE-627)SPR031602193 (SPR)s13410-014-0268-x-e DE-627 ger DE-627 rakwb eng 610 ASE Mahmoud, Ayman M. verfasserin aut In vivo and in vitro antidiabetic effects of citrus flavonoids; a study on the mechanism of action 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Type 2 diabetes mellitus is a result of hyperglycemia caused by overproduction of glucose at the hepatic level or because of abnormal β cell function or insulin resistance at target cells. The purpose of this study was to investigate the hypoglycemic effect of hesperidin and naringin and to suggest their probable mechanisms of action in high fat-fed/streptozotocin (STZ)-induced type 2 diabetic rats. Male albino rats were divided into four groups. Group 1 was normal control, and others were induced with diabetes by feeding a high-fat diet for 2 weeks followed by an intraperitoneal injection of streptozotocin (35 mg/kg b.wt.). Group 2 was kept as diabetic control, and groups 3 and 4 were further treated with an oral dose of 50 mg/kg hesperidin and naringin. In the diabetic control group, levels of glucose and glycosylated hemoglobin were significantly increased, while serum insulin level and hepatic and muscle glycogen were decreased. Both hesperidin and naringin supplementation significantly reversed these parameters. The activity of the hepatic key enzyme hexokinase was significantly increased whereas, glucose-6-phosphatase, glycogen phosphorylase, and fructose-1,6-bisphosphatase activities were significantly decreased as a result of treatment. Furthermore, both compounds were found to decrease intestinal glucose absorption in situ and to increase insulin release from isolated islets, peripheral glucose uptake in vitro, and adipose tissue glucose transporter type 4 (GLUT4) messenger RNA (mRNA) and protein expressions. These results showed that hesperidin and naringin have potent antihyperglycemic activity in high fat-fed/STZ-induced diabetic rats. Citrus flavonoids (dpeaa)DE-He213 Hesperidin (dpeaa)DE-He213 Naringin (dpeaa)DE-He213 GLUT4 (dpeaa)DE-He213 Insulin release (dpeaa)DE-He213 HFD/STZ diabetes (dpeaa)DE-He213 Ahmed, Osama M. verfasserin aut Ashour, Mohamed B. verfasserin aut Abdel-Moneim, Adel verfasserin aut Enthalten in International journal of diabetes in developing countries [Delhi] : Springer India, 2006 35(2015), 3 vom: 19. Jan., Seite 250-263 (DE-627)521483700 (DE-600)2263351-0 1998-3832 nnns volume:35 year:2015 number:3 day:19 month:01 pages:250-263 https://dx.doi.org/10.1007/s13410-014-0268-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 35 2015 3 19 01 250-263
allfields_unstemmed	10.1007/s13410-014-0268-x doi (DE-627)SPR031602193 (SPR)s13410-014-0268-x-e DE-627 ger DE-627 rakwb eng 610 ASE Mahmoud, Ayman M. verfasserin aut In vivo and in vitro antidiabetic effects of citrus flavonoids; a study on the mechanism of action 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Type 2 diabetes mellitus is a result of hyperglycemia caused by overproduction of glucose at the hepatic level or because of abnormal β cell function or insulin resistance at target cells. The purpose of this study was to investigate the hypoglycemic effect of hesperidin and naringin and to suggest their probable mechanisms of action in high fat-fed/streptozotocin (STZ)-induced type 2 diabetic rats. Male albino rats were divided into four groups. Group 1 was normal control, and others were induced with diabetes by feeding a high-fat diet for 2 weeks followed by an intraperitoneal injection of streptozotocin (35 mg/kg b.wt.). Group 2 was kept as diabetic control, and groups 3 and 4 were further treated with an oral dose of 50 mg/kg hesperidin and naringin. In the diabetic control group, levels of glucose and glycosylated hemoglobin were significantly increased, while serum insulin level and hepatic and muscle glycogen were decreased. Both hesperidin and naringin supplementation significantly reversed these parameters. The activity of the hepatic key enzyme hexokinase was significantly increased whereas, glucose-6-phosphatase, glycogen phosphorylase, and fructose-1,6-bisphosphatase activities were significantly decreased as a result of treatment. Furthermore, both compounds were found to decrease intestinal glucose absorption in situ and to increase insulin release from isolated islets, peripheral glucose uptake in vitro, and adipose tissue glucose transporter type 4 (GLUT4) messenger RNA (mRNA) and protein expressions. These results showed that hesperidin and naringin have potent antihyperglycemic activity in high fat-fed/STZ-induced diabetic rats. Citrus flavonoids (dpeaa)DE-He213 Hesperidin (dpeaa)DE-He213 Naringin (dpeaa)DE-He213 GLUT4 (dpeaa)DE-He213 Insulin release (dpeaa)DE-He213 HFD/STZ diabetes (dpeaa)DE-He213 Ahmed, Osama M. verfasserin aut Ashour, Mohamed B. verfasserin aut Abdel-Moneim, Adel verfasserin aut Enthalten in International journal of diabetes in developing countries [Delhi] : Springer India, 2006 35(2015), 3 vom: 19. Jan., Seite 250-263 (DE-627)521483700 (DE-600)2263351-0 1998-3832 nnns volume:35 year:2015 number:3 day:19 month:01 pages:250-263 https://dx.doi.org/10.1007/s13410-014-0268-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 35 2015 3 19 01 250-263
allfieldsGer	10.1007/s13410-014-0268-x doi (DE-627)SPR031602193 (SPR)s13410-014-0268-x-e DE-627 ger DE-627 rakwb eng 610 ASE Mahmoud, Ayman M. verfasserin aut In vivo and in vitro antidiabetic effects of citrus flavonoids; a study on the mechanism of action 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Type 2 diabetes mellitus is a result of hyperglycemia caused by overproduction of glucose at the hepatic level or because of abnormal β cell function or insulin resistance at target cells. The purpose of this study was to investigate the hypoglycemic effect of hesperidin and naringin and to suggest their probable mechanisms of action in high fat-fed/streptozotocin (STZ)-induced type 2 diabetic rats. Male albino rats were divided into four groups. Group 1 was normal control, and others were induced with diabetes by feeding a high-fat diet for 2 weeks followed by an intraperitoneal injection of streptozotocin (35 mg/kg b.wt.). Group 2 was kept as diabetic control, and groups 3 and 4 were further treated with an oral dose of 50 mg/kg hesperidin and naringin. In the diabetic control group, levels of glucose and glycosylated hemoglobin were significantly increased, while serum insulin level and hepatic and muscle glycogen were decreased. Both hesperidin and naringin supplementation significantly reversed these parameters. The activity of the hepatic key enzyme hexokinase was significantly increased whereas, glucose-6-phosphatase, glycogen phosphorylase, and fructose-1,6-bisphosphatase activities were significantly decreased as a result of treatment. Furthermore, both compounds were found to decrease intestinal glucose absorption in situ and to increase insulin release from isolated islets, peripheral glucose uptake in vitro, and adipose tissue glucose transporter type 4 (GLUT4) messenger RNA (mRNA) and protein expressions. These results showed that hesperidin and naringin have potent antihyperglycemic activity in high fat-fed/STZ-induced diabetic rats. Citrus flavonoids (dpeaa)DE-He213 Hesperidin (dpeaa)DE-He213 Naringin (dpeaa)DE-He213 GLUT4 (dpeaa)DE-He213 Insulin release (dpeaa)DE-He213 HFD/STZ diabetes (dpeaa)DE-He213 Ahmed, Osama M. verfasserin aut Ashour, Mohamed B. verfasserin aut Abdel-Moneim, Adel verfasserin aut Enthalten in International journal of diabetes in developing countries [Delhi] : Springer India, 2006 35(2015), 3 vom: 19. Jan., Seite 250-263 (DE-627)521483700 (DE-600)2263351-0 1998-3832 nnns volume:35 year:2015 number:3 day:19 month:01 pages:250-263 https://dx.doi.org/10.1007/s13410-014-0268-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 35 2015 3 19 01 250-263
allfieldsSound	10.1007/s13410-014-0268-x doi (DE-627)SPR031602193 (SPR)s13410-014-0268-x-e DE-627 ger DE-627 rakwb eng 610 ASE Mahmoud, Ayman M. verfasserin aut In vivo and in vitro antidiabetic effects of citrus flavonoids; a study on the mechanism of action 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Type 2 diabetes mellitus is a result of hyperglycemia caused by overproduction of glucose at the hepatic level or because of abnormal β cell function or insulin resistance at target cells. The purpose of this study was to investigate the hypoglycemic effect of hesperidin and naringin and to suggest their probable mechanisms of action in high fat-fed/streptozotocin (STZ)-induced type 2 diabetic rats. Male albino rats were divided into four groups. Group 1 was normal control, and others were induced with diabetes by feeding a high-fat diet for 2 weeks followed by an intraperitoneal injection of streptozotocin (35 mg/kg b.wt.). Group 2 was kept as diabetic control, and groups 3 and 4 were further treated with an oral dose of 50 mg/kg hesperidin and naringin. In the diabetic control group, levels of glucose and glycosylated hemoglobin were significantly increased, while serum insulin level and hepatic and muscle glycogen were decreased. Both hesperidin and naringin supplementation significantly reversed these parameters. The activity of the hepatic key enzyme hexokinase was significantly increased whereas, glucose-6-phosphatase, glycogen phosphorylase, and fructose-1,6-bisphosphatase activities were significantly decreased as a result of treatment. Furthermore, both compounds were found to decrease intestinal glucose absorption in situ and to increase insulin release from isolated islets, peripheral glucose uptake in vitro, and adipose tissue glucose transporter type 4 (GLUT4) messenger RNA (mRNA) and protein expressions. These results showed that hesperidin and naringin have potent antihyperglycemic activity in high fat-fed/STZ-induced diabetic rats. Citrus flavonoids (dpeaa)DE-He213 Hesperidin (dpeaa)DE-He213 Naringin (dpeaa)DE-He213 GLUT4 (dpeaa)DE-He213 Insulin release (dpeaa)DE-He213 HFD/STZ diabetes (dpeaa)DE-He213 Ahmed, Osama M. verfasserin aut Ashour, Mohamed B. verfasserin aut Abdel-Moneim, Adel verfasserin aut Enthalten in International journal of diabetes in developing countries [Delhi] : Springer India, 2006 35(2015), 3 vom: 19. Jan., Seite 250-263 (DE-627)521483700 (DE-600)2263351-0 1998-3832 nnns volume:35 year:2015 number:3 day:19 month:01 pages:250-263 https://dx.doi.org/10.1007/s13410-014-0268-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 35 2015 3 19 01 250-263
language	English
source	Enthalten in International journal of diabetes in developing countries 35(2015), 3 vom: 19. Jan., Seite 250-263 volume:35 year:2015 number:3 day:19 month:01 pages:250-263
sourceStr	Enthalten in International journal of diabetes in developing countries 35(2015), 3 vom: 19. Jan., Seite 250-263 volume:35 year:2015 number:3 day:19 month:01 pages:250-263
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Citrus flavonoids Hesperidin Naringin GLUT4 Insulin release HFD/STZ diabetes
dewey-raw	610
isfreeaccess_bool	false
container_title	International journal of diabetes in developing countries
authorswithroles_txt_mv	Mahmoud, Ayman M. @@aut@@ Ahmed, Osama M. @@aut@@ Ashour, Mohamed B. @@aut@@ Abdel-Moneim, Adel @@aut@@
publishDateDaySort_date	2015-01-19T00:00:00Z
hierarchy_top_id	521483700
dewey-sort	3610
id	SPR031602193
language_de	englisch
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author	Mahmoud, Ayman M.
spellingShingle	Mahmoud, Ayman M. ddc 610 misc Citrus flavonoids misc Hesperidin misc Naringin misc GLUT4 misc Insulin release misc HFD/STZ diabetes In vivo and in vitro antidiabetic effects of citrus flavonoids; a study on the mechanism of action
authorStr	Mahmoud, Ayman M.
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topic_title	610 ASE In vivo and in vitro antidiabetic effects of citrus flavonoids; a study on the mechanism of action Citrus flavonoids (dpeaa)DE-He213 Hesperidin (dpeaa)DE-He213 Naringin (dpeaa)DE-He213 GLUT4 (dpeaa)DE-He213 Insulin release (dpeaa)DE-He213 HFD/STZ diabetes (dpeaa)DE-He213
topic	ddc 610 misc Citrus flavonoids misc Hesperidin misc Naringin misc GLUT4 misc Insulin release misc HFD/STZ diabetes
topic_unstemmed	ddc 610 misc Citrus flavonoids misc Hesperidin misc Naringin misc GLUT4 misc Insulin release misc HFD/STZ diabetes
topic_browse	ddc 610 misc Citrus flavonoids misc Hesperidin misc Naringin misc GLUT4 misc Insulin release misc HFD/STZ diabetes
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hierarchy_parent_title	International journal of diabetes in developing countries
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title	In vivo and in vitro antidiabetic effects of citrus flavonoids; a study on the mechanism of action
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title_full	In vivo and in vitro antidiabetic effects of citrus flavonoids; a study on the mechanism of action
author_sort	Mahmoud, Ayman M.
journal	International journal of diabetes in developing countries
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author_browse	Mahmoud, Ayman M. Ahmed, Osama M. Ashour, Mohamed B. Abdel-Moneim, Adel
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author-letter	Mahmoud, Ayman M.
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title_sort	in vivo and in vitro antidiabetic effects of citrus flavonoids; a study on the mechanism of action
title_auth	In vivo and in vitro antidiabetic effects of citrus flavonoids; a study on the mechanism of action
abstract	Abstract Type 2 diabetes mellitus is a result of hyperglycemia caused by overproduction of glucose at the hepatic level or because of abnormal β cell function or insulin resistance at target cells. The purpose of this study was to investigate the hypoglycemic effect of hesperidin and naringin and to suggest their probable mechanisms of action in high fat-fed/streptozotocin (STZ)-induced type 2 diabetic rats. Male albino rats were divided into four groups. Group 1 was normal control, and others were induced with diabetes by feeding a high-fat diet for 2 weeks followed by an intraperitoneal injection of streptozotocin (35 mg/kg b.wt.). Group 2 was kept as diabetic control, and groups 3 and 4 were further treated with an oral dose of 50 mg/kg hesperidin and naringin. In the diabetic control group, levels of glucose and glycosylated hemoglobin were significantly increased, while serum insulin level and hepatic and muscle glycogen were decreased. Both hesperidin and naringin supplementation significantly reversed these parameters. The activity of the hepatic key enzyme hexokinase was significantly increased whereas, glucose-6-phosphatase, glycogen phosphorylase, and fructose-1,6-bisphosphatase activities were significantly decreased as a result of treatment. Furthermore, both compounds were found to decrease intestinal glucose absorption in situ and to increase insulin release from isolated islets, peripheral glucose uptake in vitro, and adipose tissue glucose transporter type 4 (GLUT4) messenger RNA (mRNA) and protein expressions. These results showed that hesperidin and naringin have potent antihyperglycemic activity in high fat-fed/STZ-induced diabetic rats.
abstractGer	Abstract Type 2 diabetes mellitus is a result of hyperglycemia caused by overproduction of glucose at the hepatic level or because of abnormal β cell function or insulin resistance at target cells. The purpose of this study was to investigate the hypoglycemic effect of hesperidin and naringin and to suggest their probable mechanisms of action in high fat-fed/streptozotocin (STZ)-induced type 2 diabetic rats. Male albino rats were divided into four groups. Group 1 was normal control, and others were induced with diabetes by feeding a high-fat diet for 2 weeks followed by an intraperitoneal injection of streptozotocin (35 mg/kg b.wt.). Group 2 was kept as diabetic control, and groups 3 and 4 were further treated with an oral dose of 50 mg/kg hesperidin and naringin. In the diabetic control group, levels of glucose and glycosylated hemoglobin were significantly increased, while serum insulin level and hepatic and muscle glycogen were decreased. Both hesperidin and naringin supplementation significantly reversed these parameters. The activity of the hepatic key enzyme hexokinase was significantly increased whereas, glucose-6-phosphatase, glycogen phosphorylase, and fructose-1,6-bisphosphatase activities were significantly decreased as a result of treatment. Furthermore, both compounds were found to decrease intestinal glucose absorption in situ and to increase insulin release from isolated islets, peripheral glucose uptake in vitro, and adipose tissue glucose transporter type 4 (GLUT4) messenger RNA (mRNA) and protein expressions. These results showed that hesperidin and naringin have potent antihyperglycemic activity in high fat-fed/STZ-induced diabetic rats.
abstract_unstemmed	Abstract Type 2 diabetes mellitus is a result of hyperglycemia caused by overproduction of glucose at the hepatic level or because of abnormal β cell function or insulin resistance at target cells. The purpose of this study was to investigate the hypoglycemic effect of hesperidin and naringin and to suggest their probable mechanisms of action in high fat-fed/streptozotocin (STZ)-induced type 2 diabetic rats. Male albino rats were divided into four groups. Group 1 was normal control, and others were induced with diabetes by feeding a high-fat diet for 2 weeks followed by an intraperitoneal injection of streptozotocin (35 mg/kg b.wt.). Group 2 was kept as diabetic control, and groups 3 and 4 were further treated with an oral dose of 50 mg/kg hesperidin and naringin. In the diabetic control group, levels of glucose and glycosylated hemoglobin were significantly increased, while serum insulin level and hepatic and muscle glycogen were decreased. Both hesperidin and naringin supplementation significantly reversed these parameters. The activity of the hepatic key enzyme hexokinase was significantly increased whereas, glucose-6-phosphatase, glycogen phosphorylase, and fructose-1,6-bisphosphatase activities were significantly decreased as a result of treatment. Furthermore, both compounds were found to decrease intestinal glucose absorption in situ and to increase insulin release from isolated islets, peripheral glucose uptake in vitro, and adipose tissue glucose transporter type 4 (GLUT4) messenger RNA (mRNA) and protein expressions. These results showed that hesperidin and naringin have potent antihyperglycemic activity in high fat-fed/STZ-induced diabetic rats.
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container_issue	3
title_short	In vivo and in vitro antidiabetic effects of citrus flavonoids; a study on the mechanism of action
url	https://dx.doi.org/10.1007/s13410-014-0268-x
remote_bool	true
author2	Ahmed, Osama M. Ashour, Mohamed B. Abdel-Moneim, Adel
author2Str	Ahmed, Osama M. Ashour, Mohamed B. Abdel-Moneim, Adel
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doi_str	10.1007/s13410-014-0268-x
up_date	2024-07-04T00:28:55.105Z
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