Oral administration of Rehmannia glutinosa extract for obesity treatment via adiposity and fatty acid binding protein expression in obese rats
Abstract We investigated the anti-obesity effect of Rehmannia glutinosa aqueous extract (RGE) in high fat diet (HFD) induced obese rats on the blood lipid concentration and expression of adipocyte fatty acid binding protein (FABP). In additional experiments, C57BL6 mice were used to determine lipoly...
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Gespeichert in:
| Autor*in: |
Park, Mi-Young [verfasserIn] Lee, Hyun Jung [verfasserIn] Choi, Da Hyeon [verfasserIn] Kang, Bong-Joo [verfasserIn] Choi, Sunmi [verfasserIn] Park, Yoon Shin [verfasserIn] |
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E-Artikel |
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Englisch |
| Erschienen: |
2017 |
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| Schlagwörter: |
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Enthalten in: Toxicology and Environmental Health Sciences - Korean Society of Environmental Risk Assessment and Health Science, 2011, 9(2017), 5 vom: Dez., Seite 309-316 |
|---|---|
| Übergeordnetes Werk: |
volume:9 ; year:2017 ; number:5 ; month:12 ; pages:309-316 |
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10.1007/s13530-017-0336-y |
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| 520 | |a Abstract We investigated the anti-obesity effect of Rehmannia glutinosa aqueous extract (RGE) in high fat diet (HFD) induced obese rats on the blood lipid concentration and expression of adipocyte fatty acid binding protein (FABP). In additional experiments, C57BL6 mice were used to determine lipolysis and the oral lipid emulsion tolerance test. RGE administration significantly reduced the size of subcutaneous adipocytes and. Most importantly, RGE administration markedly attenuated the up-regulation of FABP mRNA and protein expression in subcutaneous adipose tissue induced by an HFD. Oral RGE administration prevented weight gain and hyperlipidemia induced by long-term HFD feeding, presumably via a mechanism that inhibits the intestinal absorption of dietary fat by RGE. Taken together, RGE can act as an anti-obesity agent by lowering FABP gene and protein expression in adipose tissue as well as blood lipid levels. | ||
| 650 | 4 | |a diet induced obesity (DIO) |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a fatty acid binding protein (FABP) |7 (dpeaa)DE-He213 | |
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| 700 | 1 | |a Choi, Sunmi |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Yoon Shin |e verfasserin |4 aut | |
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10.1007/s13530-017-0336-y doi (DE-627)SPR031729533 (SPR)s13530-017-0336-y-e DE-627 ger DE-627 rakwb eng Park, Mi-Young verfasserin aut Oral administration of Rehmannia glutinosa extract for obesity treatment via adiposity and fatty acid binding protein expression in obese rats 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract We investigated the anti-obesity effect of Rehmannia glutinosa aqueous extract (RGE) in high fat diet (HFD) induced obese rats on the blood lipid concentration and expression of adipocyte fatty acid binding protein (FABP). In additional experiments, C57BL6 mice were used to determine lipolysis and the oral lipid emulsion tolerance test. RGE administration significantly reduced the size of subcutaneous adipocytes and. Most importantly, RGE administration markedly attenuated the up-regulation of FABP mRNA and protein expression in subcutaneous adipose tissue induced by an HFD. Oral RGE administration prevented weight gain and hyperlipidemia induced by long-term HFD feeding, presumably via a mechanism that inhibits the intestinal absorption of dietary fat by RGE. Taken together, RGE can act as an anti-obesity agent by lowering FABP gene and protein expression in adipose tissue as well as blood lipid levels. diet induced obesity (DIO) (dpeaa)DE-He213 fatty acid binding protein (FABP) (dpeaa)DE-He213 high fat diet (HFD) (dpeaa)DE-He213 obesity (dpeaa)DE-He213 Lee, Hyun Jung verfasserin aut Choi, Da Hyeon verfasserin aut Kang, Bong-Joo verfasserin aut Choi, Sunmi verfasserin aut Park, Yoon Shin verfasserin aut Enthalten in Toxicology and Environmental Health Sciences Korean Society of Environmental Risk Assessment and Health Science, 2011 9(2017), 5 vom: Dez., Seite 309-316 (DE-627)SPR031726593 nnns volume:9 year:2017 number:5 month:12 pages:309-316 https://dx.doi.org/10.1007/s13530-017-0336-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 9 2017 5 12 309-316 |
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10.1007/s13530-017-0336-y doi (DE-627)SPR031729533 (SPR)s13530-017-0336-y-e DE-627 ger DE-627 rakwb eng Park, Mi-Young verfasserin aut Oral administration of Rehmannia glutinosa extract for obesity treatment via adiposity and fatty acid binding protein expression in obese rats 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract We investigated the anti-obesity effect of Rehmannia glutinosa aqueous extract (RGE) in high fat diet (HFD) induced obese rats on the blood lipid concentration and expression of adipocyte fatty acid binding protein (FABP). In additional experiments, C57BL6 mice were used to determine lipolysis and the oral lipid emulsion tolerance test. RGE administration significantly reduced the size of subcutaneous adipocytes and. Most importantly, RGE administration markedly attenuated the up-regulation of FABP mRNA and protein expression in subcutaneous adipose tissue induced by an HFD. Oral RGE administration prevented weight gain and hyperlipidemia induced by long-term HFD feeding, presumably via a mechanism that inhibits the intestinal absorption of dietary fat by RGE. Taken together, RGE can act as an anti-obesity agent by lowering FABP gene and protein expression in adipose tissue as well as blood lipid levels. diet induced obesity (DIO) (dpeaa)DE-He213 fatty acid binding protein (FABP) (dpeaa)DE-He213 high fat diet (HFD) (dpeaa)DE-He213 obesity (dpeaa)DE-He213 Lee, Hyun Jung verfasserin aut Choi, Da Hyeon verfasserin aut Kang, Bong-Joo verfasserin aut Choi, Sunmi verfasserin aut Park, Yoon Shin verfasserin aut Enthalten in Toxicology and Environmental Health Sciences Korean Society of Environmental Risk Assessment and Health Science, 2011 9(2017), 5 vom: Dez., Seite 309-316 (DE-627)SPR031726593 nnns volume:9 year:2017 number:5 month:12 pages:309-316 https://dx.doi.org/10.1007/s13530-017-0336-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 9 2017 5 12 309-316 |
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10.1007/s13530-017-0336-y doi (DE-627)SPR031729533 (SPR)s13530-017-0336-y-e DE-627 ger DE-627 rakwb eng Park, Mi-Young verfasserin aut Oral administration of Rehmannia glutinosa extract for obesity treatment via adiposity and fatty acid binding protein expression in obese rats 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract We investigated the anti-obesity effect of Rehmannia glutinosa aqueous extract (RGE) in high fat diet (HFD) induced obese rats on the blood lipid concentration and expression of adipocyte fatty acid binding protein (FABP). In additional experiments, C57BL6 mice were used to determine lipolysis and the oral lipid emulsion tolerance test. RGE administration significantly reduced the size of subcutaneous adipocytes and. Most importantly, RGE administration markedly attenuated the up-regulation of FABP mRNA and protein expression in subcutaneous adipose tissue induced by an HFD. Oral RGE administration prevented weight gain and hyperlipidemia induced by long-term HFD feeding, presumably via a mechanism that inhibits the intestinal absorption of dietary fat by RGE. Taken together, RGE can act as an anti-obesity agent by lowering FABP gene and protein expression in adipose tissue as well as blood lipid levels. diet induced obesity (DIO) (dpeaa)DE-He213 fatty acid binding protein (FABP) (dpeaa)DE-He213 high fat diet (HFD) (dpeaa)DE-He213 obesity (dpeaa)DE-He213 Lee, Hyun Jung verfasserin aut Choi, Da Hyeon verfasserin aut Kang, Bong-Joo verfasserin aut Choi, Sunmi verfasserin aut Park, Yoon Shin verfasserin aut Enthalten in Toxicology and Environmental Health Sciences Korean Society of Environmental Risk Assessment and Health Science, 2011 9(2017), 5 vom: Dez., Seite 309-316 (DE-627)SPR031726593 nnns volume:9 year:2017 number:5 month:12 pages:309-316 https://dx.doi.org/10.1007/s13530-017-0336-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 9 2017 5 12 309-316 |
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10.1007/s13530-017-0336-y doi (DE-627)SPR031729533 (SPR)s13530-017-0336-y-e DE-627 ger DE-627 rakwb eng Park, Mi-Young verfasserin aut Oral administration of Rehmannia glutinosa extract for obesity treatment via adiposity and fatty acid binding protein expression in obese rats 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract We investigated the anti-obesity effect of Rehmannia glutinosa aqueous extract (RGE) in high fat diet (HFD) induced obese rats on the blood lipid concentration and expression of adipocyte fatty acid binding protein (FABP). In additional experiments, C57BL6 mice were used to determine lipolysis and the oral lipid emulsion tolerance test. RGE administration significantly reduced the size of subcutaneous adipocytes and. Most importantly, RGE administration markedly attenuated the up-regulation of FABP mRNA and protein expression in subcutaneous adipose tissue induced by an HFD. Oral RGE administration prevented weight gain and hyperlipidemia induced by long-term HFD feeding, presumably via a mechanism that inhibits the intestinal absorption of dietary fat by RGE. Taken together, RGE can act as an anti-obesity agent by lowering FABP gene and protein expression in adipose tissue as well as blood lipid levels. diet induced obesity (DIO) (dpeaa)DE-He213 fatty acid binding protein (FABP) (dpeaa)DE-He213 high fat diet (HFD) (dpeaa)DE-He213 obesity (dpeaa)DE-He213 Lee, Hyun Jung verfasserin aut Choi, Da Hyeon verfasserin aut Kang, Bong-Joo verfasserin aut Choi, Sunmi verfasserin aut Park, Yoon Shin verfasserin aut Enthalten in Toxicology and Environmental Health Sciences Korean Society of Environmental Risk Assessment and Health Science, 2011 9(2017), 5 vom: Dez., Seite 309-316 (DE-627)SPR031726593 nnns volume:9 year:2017 number:5 month:12 pages:309-316 https://dx.doi.org/10.1007/s13530-017-0336-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 9 2017 5 12 309-316 |
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10.1007/s13530-017-0336-y doi (DE-627)SPR031729533 (SPR)s13530-017-0336-y-e DE-627 ger DE-627 rakwb eng Park, Mi-Young verfasserin aut Oral administration of Rehmannia glutinosa extract for obesity treatment via adiposity and fatty acid binding protein expression in obese rats 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract We investigated the anti-obesity effect of Rehmannia glutinosa aqueous extract (RGE) in high fat diet (HFD) induced obese rats on the blood lipid concentration and expression of adipocyte fatty acid binding protein (FABP). In additional experiments, C57BL6 mice were used to determine lipolysis and the oral lipid emulsion tolerance test. RGE administration significantly reduced the size of subcutaneous adipocytes and. Most importantly, RGE administration markedly attenuated the up-regulation of FABP mRNA and protein expression in subcutaneous adipose tissue induced by an HFD. Oral RGE administration prevented weight gain and hyperlipidemia induced by long-term HFD feeding, presumably via a mechanism that inhibits the intestinal absorption of dietary fat by RGE. Taken together, RGE can act as an anti-obesity agent by lowering FABP gene and protein expression in adipose tissue as well as blood lipid levels. diet induced obesity (DIO) (dpeaa)DE-He213 fatty acid binding protein (FABP) (dpeaa)DE-He213 high fat diet (HFD) (dpeaa)DE-He213 obesity (dpeaa)DE-He213 Lee, Hyun Jung verfasserin aut Choi, Da Hyeon verfasserin aut Kang, Bong-Joo verfasserin aut Choi, Sunmi verfasserin aut Park, Yoon Shin verfasserin aut Enthalten in Toxicology and Environmental Health Sciences Korean Society of Environmental Risk Assessment and Health Science, 2011 9(2017), 5 vom: Dez., Seite 309-316 (DE-627)SPR031726593 nnns volume:9 year:2017 number:5 month:12 pages:309-316 https://dx.doi.org/10.1007/s13530-017-0336-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 9 2017 5 12 309-316 |
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Oral administration of Rehmannia glutinosa extract for obesity treatment via adiposity and fatty acid binding protein expression in obese rats |
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Abstract We investigated the anti-obesity effect of Rehmannia glutinosa aqueous extract (RGE) in high fat diet (HFD) induced obese rats on the blood lipid concentration and expression of adipocyte fatty acid binding protein (FABP). In additional experiments, C57BL6 mice were used to determine lipolysis and the oral lipid emulsion tolerance test. RGE administration significantly reduced the size of subcutaneous adipocytes and. Most importantly, RGE administration markedly attenuated the up-regulation of FABP mRNA and protein expression in subcutaneous adipose tissue induced by an HFD. Oral RGE administration prevented weight gain and hyperlipidemia induced by long-term HFD feeding, presumably via a mechanism that inhibits the intestinal absorption of dietary fat by RGE. Taken together, RGE can act as an anti-obesity agent by lowering FABP gene and protein expression in adipose tissue as well as blood lipid levels. |
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Abstract We investigated the anti-obesity effect of Rehmannia glutinosa aqueous extract (RGE) in high fat diet (HFD) induced obese rats on the blood lipid concentration and expression of adipocyte fatty acid binding protein (FABP). In additional experiments, C57BL6 mice were used to determine lipolysis and the oral lipid emulsion tolerance test. RGE administration significantly reduced the size of subcutaneous adipocytes and. Most importantly, RGE administration markedly attenuated the up-regulation of FABP mRNA and protein expression in subcutaneous adipose tissue induced by an HFD. Oral RGE administration prevented weight gain and hyperlipidemia induced by long-term HFD feeding, presumably via a mechanism that inhibits the intestinal absorption of dietary fat by RGE. Taken together, RGE can act as an anti-obesity agent by lowering FABP gene and protein expression in adipose tissue as well as blood lipid levels. |
| abstract_unstemmed |
Abstract We investigated the anti-obesity effect of Rehmannia glutinosa aqueous extract (RGE) in high fat diet (HFD) induced obese rats on the blood lipid concentration and expression of adipocyte fatty acid binding protein (FABP). In additional experiments, C57BL6 mice were used to determine lipolysis and the oral lipid emulsion tolerance test. RGE administration significantly reduced the size of subcutaneous adipocytes and. Most importantly, RGE administration markedly attenuated the up-regulation of FABP mRNA and protein expression in subcutaneous adipose tissue induced by an HFD. Oral RGE administration prevented weight gain and hyperlipidemia induced by long-term HFD feeding, presumably via a mechanism that inhibits the intestinal absorption of dietary fat by RGE. Taken together, RGE can act as an anti-obesity agent by lowering FABP gene and protein expression in adipose tissue as well as blood lipid levels. |
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Oral administration of Rehmannia glutinosa extract for obesity treatment via adiposity and fatty acid binding protein expression in obese rats |
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https://dx.doi.org/10.1007/s13530-017-0336-y |
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Lee, Hyun Jung Choi, Da Hyeon Kang, Bong-Joo Choi, Sunmi Park, Yoon Shin |
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Lee, Hyun Jung Choi, Da Hyeon Kang, Bong-Joo Choi, Sunmi Park, Yoon Shin |
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10.1007/s13530-017-0336-y |
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2024-07-04T01:01:12.979Z |
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