Heterogeneity of microsphere distribution in resected liver and tumour tissue following selective intrahepatic radiotherapy

Background Selective arterial radioembolisation of liver tumours has increased, because of encouraging efficacy reports; however, therapeutic parameters used in external beam therapy are not applicable for understanding and predicting potential toxicity and efficacy, necessitating further studies of...
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Autor*in:	Högberg, Jonas [verfasserIn] Rizell, Magnus [verfasserIn] Hultborn, Ragnar [verfasserIn] Svensson, Johanna [verfasserIn] Henrikson, Olof [verfasserIn] Mölne, Johan [verfasserIn] Gjertsson, Peter [verfasserIn] Bernhardt, Peter [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	Radioembolisation Y-90 SIR Surgery Activity heterogeneity

Übergeordnetes Werk:	Enthalten in: EJNMMI Research - Berlin : Springer, 2011, 4(2014), 1 vom: 16. Sept.
Übergeordnetes Werk:	volume:4 ; year:2014 ; number:1 ; day:16 ; month:09

Links:	Volltext

DOI / URN:	10.1186/s13550-014-0048-0

Katalog-ID:	SPR031779638

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520			\|a Background Selective arterial radioembolisation of liver tumours has increased, because of encouraging efficacy reports; however, therapeutic parameters used in external beam therapy are not applicable for understanding and predicting potential toxicity and efficacy, necessitating further studies of the physical and biological characteristics of radioembolisation. The aim was to characterise heterogeneity in the distribution of microspheres on a therapeutically relevant geometric scale considering the range of yttrium-90 (90Y) β-particles. Methods Two patients with intrahepatic cholangiocarcinoma, marginally resectable, were treated by selective arterial embolisation with 90Y resin microspheres (SIRTEX®), followed 9 days post-infusion by resection, including macroscopic tumour tissue and surrounding normal liver parenchyma. Formalin-fixed, sectioned resected tissues were exposed to autoradiographic films, or tissue biopsies of various dimensions were punched out for activity measurements and microscopy. Results Autoradiography and activity measurements revealed a higher activity in tumour tissue compared to normal liver parenchyma. Heterogeneity in activity distribution was evident in both normal liver and tumour tissue. Activity measurements were analysed in relation to the sample mass (5 to 422 mg), and heterogeneities were detected by statistical means; the larger the tissue biopsies, the smaller was the coefficient of variation. The skewness of the activity distributions increased with decreasing biopsy mass. Conclusions The tissue activity distributions in normal tissue were heterogeneous on a relevant geometric scale considering the range of the ionising electrons. Given the similar and repetitive structure of the liver parenchyma, this finding could partly explain the tolerance of a relatively high mean absorbed dose to the liver parenchyma from β-particles.
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700	1		\|a Mölne, Johan \|e verfasserin \|4 aut
700	1		\|a Gjertsson, Peter \|e verfasserin \|4 aut
700	1		\|a Bernhardt, Peter \|e verfasserin \|4 aut
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allfields	10.1186/s13550-014-0048-0 doi (DE-627)SPR031779638 (SPR)s13550-014-0048-0-e DE-627 ger DE-627 rakwb eng 610 ASE Högberg, Jonas verfasserin aut Heterogeneity of microsphere distribution in resected liver and tumour tissue following selective intrahepatic radiotherapy 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Selective arterial radioembolisation of liver tumours has increased, because of encouraging efficacy reports; however, therapeutic parameters used in external beam therapy are not applicable for understanding and predicting potential toxicity and efficacy, necessitating further studies of the physical and biological characteristics of radioembolisation. The aim was to characterise heterogeneity in the distribution of microspheres on a therapeutically relevant geometric scale considering the range of yttrium-90 (90Y) β-particles. Methods Two patients with intrahepatic cholangiocarcinoma, marginally resectable, were treated by selective arterial embolisation with 90Y resin microspheres (SIRTEX®), followed 9 days post-infusion by resection, including macroscopic tumour tissue and surrounding normal liver parenchyma. Formalin-fixed, sectioned resected tissues were exposed to autoradiographic films, or tissue biopsies of various dimensions were punched out for activity measurements and microscopy. Results Autoradiography and activity measurements revealed a higher activity in tumour tissue compared to normal liver parenchyma. Heterogeneity in activity distribution was evident in both normal liver and tumour tissue. Activity measurements were analysed in relation to the sample mass (5 to 422 mg), and heterogeneities were detected by statistical means; the larger the tissue biopsies, the smaller was the coefficient of variation. The skewness of the activity distributions increased with decreasing biopsy mass. Conclusions The tissue activity distributions in normal tissue were heterogeneous on a relevant geometric scale considering the range of the ionising electrons. Given the similar and repetitive structure of the liver parenchyma, this finding could partly explain the tolerance of a relatively high mean absorbed dose to the liver parenchyma from β-particles. Radioembolisation (dpeaa)DE-He213 Y-90 (dpeaa)DE-He213 SIR (dpeaa)DE-He213 Surgery (dpeaa)DE-He213 Activity heterogeneity (dpeaa)DE-He213 Rizell, Magnus verfasserin aut Hultborn, Ragnar verfasserin aut Svensson, Johanna verfasserin aut Henrikson, Olof verfasserin aut Mölne, Johan verfasserin aut Gjertsson, Peter verfasserin aut Bernhardt, Peter verfasserin aut Enthalten in EJNMMI Research Berlin : Springer, 2011 4(2014), 1 vom: 16. Sept. (DE-627)664970265 (DE-600)2619892-7 2191-219X nnns volume:4 year:2014 number:1 day:16 month:09 https://dx.doi.org/10.1186/s13550-014-0048-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2014 1 16 09
spelling	10.1186/s13550-014-0048-0 doi (DE-627)SPR031779638 (SPR)s13550-014-0048-0-e DE-627 ger DE-627 rakwb eng 610 ASE Högberg, Jonas verfasserin aut Heterogeneity of microsphere distribution in resected liver and tumour tissue following selective intrahepatic radiotherapy 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Selective arterial radioembolisation of liver tumours has increased, because of encouraging efficacy reports; however, therapeutic parameters used in external beam therapy are not applicable for understanding and predicting potential toxicity and efficacy, necessitating further studies of the physical and biological characteristics of radioembolisation. The aim was to characterise heterogeneity in the distribution of microspheres on a therapeutically relevant geometric scale considering the range of yttrium-90 (90Y) β-particles. Methods Two patients with intrahepatic cholangiocarcinoma, marginally resectable, were treated by selective arterial embolisation with 90Y resin microspheres (SIRTEX®), followed 9 days post-infusion by resection, including macroscopic tumour tissue and surrounding normal liver parenchyma. Formalin-fixed, sectioned resected tissues were exposed to autoradiographic films, or tissue biopsies of various dimensions were punched out for activity measurements and microscopy. Results Autoradiography and activity measurements revealed a higher activity in tumour tissue compared to normal liver parenchyma. Heterogeneity in activity distribution was evident in both normal liver and tumour tissue. Activity measurements were analysed in relation to the sample mass (5 to 422 mg), and heterogeneities were detected by statistical means; the larger the tissue biopsies, the smaller was the coefficient of variation. The skewness of the activity distributions increased with decreasing biopsy mass. Conclusions The tissue activity distributions in normal tissue were heterogeneous on a relevant geometric scale considering the range of the ionising electrons. Given the similar and repetitive structure of the liver parenchyma, this finding could partly explain the tolerance of a relatively high mean absorbed dose to the liver parenchyma from β-particles. Radioembolisation (dpeaa)DE-He213 Y-90 (dpeaa)DE-He213 SIR (dpeaa)DE-He213 Surgery (dpeaa)DE-He213 Activity heterogeneity (dpeaa)DE-He213 Rizell, Magnus verfasserin aut Hultborn, Ragnar verfasserin aut Svensson, Johanna verfasserin aut Henrikson, Olof verfasserin aut Mölne, Johan verfasserin aut Gjertsson, Peter verfasserin aut Bernhardt, Peter verfasserin aut Enthalten in EJNMMI Research Berlin : Springer, 2011 4(2014), 1 vom: 16. Sept. (DE-627)664970265 (DE-600)2619892-7 2191-219X nnns volume:4 year:2014 number:1 day:16 month:09 https://dx.doi.org/10.1186/s13550-014-0048-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2014 1 16 09
allfields_unstemmed	10.1186/s13550-014-0048-0 doi (DE-627)SPR031779638 (SPR)s13550-014-0048-0-e DE-627 ger DE-627 rakwb eng 610 ASE Högberg, Jonas verfasserin aut Heterogeneity of microsphere distribution in resected liver and tumour tissue following selective intrahepatic radiotherapy 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Selective arterial radioembolisation of liver tumours has increased, because of encouraging efficacy reports; however, therapeutic parameters used in external beam therapy are not applicable for understanding and predicting potential toxicity and efficacy, necessitating further studies of the physical and biological characteristics of radioembolisation. The aim was to characterise heterogeneity in the distribution of microspheres on a therapeutically relevant geometric scale considering the range of yttrium-90 (90Y) β-particles. Methods Two patients with intrahepatic cholangiocarcinoma, marginally resectable, were treated by selective arterial embolisation with 90Y resin microspheres (SIRTEX®), followed 9 days post-infusion by resection, including macroscopic tumour tissue and surrounding normal liver parenchyma. Formalin-fixed, sectioned resected tissues were exposed to autoradiographic films, or tissue biopsies of various dimensions were punched out for activity measurements and microscopy. Results Autoradiography and activity measurements revealed a higher activity in tumour tissue compared to normal liver parenchyma. Heterogeneity in activity distribution was evident in both normal liver and tumour tissue. Activity measurements were analysed in relation to the sample mass (5 to 422 mg), and heterogeneities were detected by statistical means; the larger the tissue biopsies, the smaller was the coefficient of variation. The skewness of the activity distributions increased with decreasing biopsy mass. Conclusions The tissue activity distributions in normal tissue were heterogeneous on a relevant geometric scale considering the range of the ionising electrons. Given the similar and repetitive structure of the liver parenchyma, this finding could partly explain the tolerance of a relatively high mean absorbed dose to the liver parenchyma from β-particles. Radioembolisation (dpeaa)DE-He213 Y-90 (dpeaa)DE-He213 SIR (dpeaa)DE-He213 Surgery (dpeaa)DE-He213 Activity heterogeneity (dpeaa)DE-He213 Rizell, Magnus verfasserin aut Hultborn, Ragnar verfasserin aut Svensson, Johanna verfasserin aut Henrikson, Olof verfasserin aut Mölne, Johan verfasserin aut Gjertsson, Peter verfasserin aut Bernhardt, Peter verfasserin aut Enthalten in EJNMMI Research Berlin : Springer, 2011 4(2014), 1 vom: 16. Sept. (DE-627)664970265 (DE-600)2619892-7 2191-219X nnns volume:4 year:2014 number:1 day:16 month:09 https://dx.doi.org/10.1186/s13550-014-0048-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2014 1 16 09
allfieldsGer	10.1186/s13550-014-0048-0 doi (DE-627)SPR031779638 (SPR)s13550-014-0048-0-e DE-627 ger DE-627 rakwb eng 610 ASE Högberg, Jonas verfasserin aut Heterogeneity of microsphere distribution in resected liver and tumour tissue following selective intrahepatic radiotherapy 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Selective arterial radioembolisation of liver tumours has increased, because of encouraging efficacy reports; however, therapeutic parameters used in external beam therapy are not applicable for understanding and predicting potential toxicity and efficacy, necessitating further studies of the physical and biological characteristics of radioembolisation. The aim was to characterise heterogeneity in the distribution of microspheres on a therapeutically relevant geometric scale considering the range of yttrium-90 (90Y) β-particles. Methods Two patients with intrahepatic cholangiocarcinoma, marginally resectable, were treated by selective arterial embolisation with 90Y resin microspheres (SIRTEX®), followed 9 days post-infusion by resection, including macroscopic tumour tissue and surrounding normal liver parenchyma. Formalin-fixed, sectioned resected tissues were exposed to autoradiographic films, or tissue biopsies of various dimensions were punched out for activity measurements and microscopy. Results Autoradiography and activity measurements revealed a higher activity in tumour tissue compared to normal liver parenchyma. Heterogeneity in activity distribution was evident in both normal liver and tumour tissue. Activity measurements were analysed in relation to the sample mass (5 to 422 mg), and heterogeneities were detected by statistical means; the larger the tissue biopsies, the smaller was the coefficient of variation. The skewness of the activity distributions increased with decreasing biopsy mass. Conclusions The tissue activity distributions in normal tissue were heterogeneous on a relevant geometric scale considering the range of the ionising electrons. Given the similar and repetitive structure of the liver parenchyma, this finding could partly explain the tolerance of a relatively high mean absorbed dose to the liver parenchyma from β-particles. Radioembolisation (dpeaa)DE-He213 Y-90 (dpeaa)DE-He213 SIR (dpeaa)DE-He213 Surgery (dpeaa)DE-He213 Activity heterogeneity (dpeaa)DE-He213 Rizell, Magnus verfasserin aut Hultborn, Ragnar verfasserin aut Svensson, Johanna verfasserin aut Henrikson, Olof verfasserin aut Mölne, Johan verfasserin aut Gjertsson, Peter verfasserin aut Bernhardt, Peter verfasserin aut Enthalten in EJNMMI Research Berlin : Springer, 2011 4(2014), 1 vom: 16. Sept. (DE-627)664970265 (DE-600)2619892-7 2191-219X nnns volume:4 year:2014 number:1 day:16 month:09 https://dx.doi.org/10.1186/s13550-014-0048-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2014 1 16 09
allfieldsSound	10.1186/s13550-014-0048-0 doi (DE-627)SPR031779638 (SPR)s13550-014-0048-0-e DE-627 ger DE-627 rakwb eng 610 ASE Högberg, Jonas verfasserin aut Heterogeneity of microsphere distribution in resected liver and tumour tissue following selective intrahepatic radiotherapy 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Selective arterial radioembolisation of liver tumours has increased, because of encouraging efficacy reports; however, therapeutic parameters used in external beam therapy are not applicable for understanding and predicting potential toxicity and efficacy, necessitating further studies of the physical and biological characteristics of radioembolisation. The aim was to characterise heterogeneity in the distribution of microspheres on a therapeutically relevant geometric scale considering the range of yttrium-90 (90Y) β-particles. Methods Two patients with intrahepatic cholangiocarcinoma, marginally resectable, were treated by selective arterial embolisation with 90Y resin microspheres (SIRTEX®), followed 9 days post-infusion by resection, including macroscopic tumour tissue and surrounding normal liver parenchyma. Formalin-fixed, sectioned resected tissues were exposed to autoradiographic films, or tissue biopsies of various dimensions were punched out for activity measurements and microscopy. Results Autoradiography and activity measurements revealed a higher activity in tumour tissue compared to normal liver parenchyma. Heterogeneity in activity distribution was evident in both normal liver and tumour tissue. Activity measurements were analysed in relation to the sample mass (5 to 422 mg), and heterogeneities were detected by statistical means; the larger the tissue biopsies, the smaller was the coefficient of variation. The skewness of the activity distributions increased with decreasing biopsy mass. Conclusions The tissue activity distributions in normal tissue were heterogeneous on a relevant geometric scale considering the range of the ionising electrons. Given the similar and repetitive structure of the liver parenchyma, this finding could partly explain the tolerance of a relatively high mean absorbed dose to the liver parenchyma from β-particles. Radioembolisation (dpeaa)DE-He213 Y-90 (dpeaa)DE-He213 SIR (dpeaa)DE-He213 Surgery (dpeaa)DE-He213 Activity heterogeneity (dpeaa)DE-He213 Rizell, Magnus verfasserin aut Hultborn, Ragnar verfasserin aut Svensson, Johanna verfasserin aut Henrikson, Olof verfasserin aut Mölne, Johan verfasserin aut Gjertsson, Peter verfasserin aut Bernhardt, Peter verfasserin aut Enthalten in EJNMMI Research Berlin : Springer, 2011 4(2014), 1 vom: 16. Sept. (DE-627)664970265 (DE-600)2619892-7 2191-219X nnns volume:4 year:2014 number:1 day:16 month:09 https://dx.doi.org/10.1186/s13550-014-0048-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2014 1 16 09
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source	Enthalten in EJNMMI Research 4(2014), 1 vom: 16. Sept. volume:4 year:2014 number:1 day:16 month:09
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The aim was to characterise heterogeneity in the distribution of microspheres on a therapeutically relevant geometric scale considering the range of yttrium-90 (90Y) β-particles. Methods Two patients with intrahepatic cholangiocarcinoma, marginally resectable, were treated by selective arterial embolisation with 90Y resin microspheres (SIRTEX®), followed 9 days post-infusion by resection, including macroscopic tumour tissue and surrounding normal liver parenchyma. Formalin-fixed, sectioned resected tissues were exposed to autoradiographic films, or tissue biopsies of various dimensions were punched out for activity measurements and microscopy. Results Autoradiography and activity measurements revealed a higher activity in tumour tissue compared to normal liver parenchyma. Heterogeneity in activity distribution was evident in both normal liver and tumour tissue. Activity measurements were analysed in relation to the sample mass (5 to 422 mg), and heterogeneities were detected by statistical means; the larger the tissue biopsies, the smaller was the coefficient of variation. The skewness of the activity distributions increased with decreasing biopsy mass. Conclusions The tissue activity distributions in normal tissue were heterogeneous on a relevant geometric scale considering the range of the ionising electrons. 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author	Högberg, Jonas
spellingShingle	Högberg, Jonas ddc 610 misc Radioembolisation misc Y-90 misc SIR misc Surgery misc Activity heterogeneity Heterogeneity of microsphere distribution in resected liver and tumour tissue following selective intrahepatic radiotherapy
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topic_title	610 ASE Heterogeneity of microsphere distribution in resected liver and tumour tissue following selective intrahepatic radiotherapy Radioembolisation (dpeaa)DE-He213 Y-90 (dpeaa)DE-He213 SIR (dpeaa)DE-He213 Surgery (dpeaa)DE-He213 Activity heterogeneity (dpeaa)DE-He213
topic	ddc 610 misc Radioembolisation misc Y-90 misc SIR misc Surgery misc Activity heterogeneity
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title	Heterogeneity of microsphere distribution in resected liver and tumour tissue following selective intrahepatic radiotherapy
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title_full	Heterogeneity of microsphere distribution in resected liver and tumour tissue following selective intrahepatic radiotherapy
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title_sort	heterogeneity of microsphere distribution in resected liver and tumour tissue following selective intrahepatic radiotherapy
title_auth	Heterogeneity of microsphere distribution in resected liver and tumour tissue following selective intrahepatic radiotherapy
abstract	Background Selective arterial radioembolisation of liver tumours has increased, because of encouraging efficacy reports; however, therapeutic parameters used in external beam therapy are not applicable for understanding and predicting potential toxicity and efficacy, necessitating further studies of the physical and biological characteristics of radioembolisation. The aim was to characterise heterogeneity in the distribution of microspheres on a therapeutically relevant geometric scale considering the range of yttrium-90 (90Y) β-particles. Methods Two patients with intrahepatic cholangiocarcinoma, marginally resectable, were treated by selective arterial embolisation with 90Y resin microspheres (SIRTEX®), followed 9 days post-infusion by resection, including macroscopic tumour tissue and surrounding normal liver parenchyma. Formalin-fixed, sectioned resected tissues were exposed to autoradiographic films, or tissue biopsies of various dimensions were punched out for activity measurements and microscopy. Results Autoradiography and activity measurements revealed a higher activity in tumour tissue compared to normal liver parenchyma. Heterogeneity in activity distribution was evident in both normal liver and tumour tissue. Activity measurements were analysed in relation to the sample mass (5 to 422 mg), and heterogeneities were detected by statistical means; the larger the tissue biopsies, the smaller was the coefficient of variation. The skewness of the activity distributions increased with decreasing biopsy mass. Conclusions The tissue activity distributions in normal tissue were heterogeneous on a relevant geometric scale considering the range of the ionising electrons. Given the similar and repetitive structure of the liver parenchyma, this finding could partly explain the tolerance of a relatively high mean absorbed dose to the liver parenchyma from β-particles.
abstractGer	Background Selective arterial radioembolisation of liver tumours has increased, because of encouraging efficacy reports; however, therapeutic parameters used in external beam therapy are not applicable for understanding and predicting potential toxicity and efficacy, necessitating further studies of the physical and biological characteristics of radioembolisation. The aim was to characterise heterogeneity in the distribution of microspheres on a therapeutically relevant geometric scale considering the range of yttrium-90 (90Y) β-particles. Methods Two patients with intrahepatic cholangiocarcinoma, marginally resectable, were treated by selective arterial embolisation with 90Y resin microspheres (SIRTEX®), followed 9 days post-infusion by resection, including macroscopic tumour tissue and surrounding normal liver parenchyma. Formalin-fixed, sectioned resected tissues were exposed to autoradiographic films, or tissue biopsies of various dimensions were punched out for activity measurements and microscopy. Results Autoradiography and activity measurements revealed a higher activity in tumour tissue compared to normal liver parenchyma. Heterogeneity in activity distribution was evident in both normal liver and tumour tissue. Activity measurements were analysed in relation to the sample mass (5 to 422 mg), and heterogeneities were detected by statistical means; the larger the tissue biopsies, the smaller was the coefficient of variation. The skewness of the activity distributions increased with decreasing biopsy mass. Conclusions The tissue activity distributions in normal tissue were heterogeneous on a relevant geometric scale considering the range of the ionising electrons. Given the similar and repetitive structure of the liver parenchyma, this finding could partly explain the tolerance of a relatively high mean absorbed dose to the liver parenchyma from β-particles.
abstract_unstemmed	Background Selective arterial radioembolisation of liver tumours has increased, because of encouraging efficacy reports; however, therapeutic parameters used in external beam therapy are not applicable for understanding and predicting potential toxicity and efficacy, necessitating further studies of the physical and biological characteristics of radioembolisation. The aim was to characterise heterogeneity in the distribution of microspheres on a therapeutically relevant geometric scale considering the range of yttrium-90 (90Y) β-particles. Methods Two patients with intrahepatic cholangiocarcinoma, marginally resectable, were treated by selective arterial embolisation with 90Y resin microspheres (SIRTEX®), followed 9 days post-infusion by resection, including macroscopic tumour tissue and surrounding normal liver parenchyma. Formalin-fixed, sectioned resected tissues were exposed to autoradiographic films, or tissue biopsies of various dimensions were punched out for activity measurements and microscopy. Results Autoradiography and activity measurements revealed a higher activity in tumour tissue compared to normal liver parenchyma. Heterogeneity in activity distribution was evident in both normal liver and tumour tissue. Activity measurements were analysed in relation to the sample mass (5 to 422 mg), and heterogeneities were detected by statistical means; the larger the tissue biopsies, the smaller was the coefficient of variation. The skewness of the activity distributions increased with decreasing biopsy mass. Conclusions The tissue activity distributions in normal tissue were heterogeneous on a relevant geometric scale considering the range of the ionising electrons. Given the similar and repetitive structure of the liver parenchyma, this finding could partly explain the tolerance of a relatively high mean absorbed dose to the liver parenchyma from β-particles.
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title_short	Heterogeneity of microsphere distribution in resected liver and tumour tissue following selective intrahepatic radiotherapy
url	https://dx.doi.org/10.1186/s13550-014-0048-0
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author2	Rizell, Magnus Hultborn, Ragnar Svensson, Johanna Henrikson, Olof Mölne, Johan Gjertsson, Peter Bernhardt, Peter
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up_date	2024-07-04T01:12:12.749Z
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The aim was to characterise heterogeneity in the distribution of microspheres on a therapeutically relevant geometric scale considering the range of yttrium-90 (90Y) β-particles. Methods Two patients with intrahepatic cholangiocarcinoma, marginally resectable, were treated by selective arterial embolisation with 90Y resin microspheres (SIRTEX®), followed 9 days post-infusion by resection, including macroscopic tumour tissue and surrounding normal liver parenchyma. Formalin-fixed, sectioned resected tissues were exposed to autoradiographic films, or tissue biopsies of various dimensions were punched out for activity measurements and microscopy. Results Autoradiography and activity measurements revealed a higher activity in tumour tissue compared to normal liver parenchyma. Heterogeneity in activity distribution was evident in both normal liver and tumour tissue. Activity measurements were analysed in relation to the sample mass (5 to 422 mg), and heterogeneities were detected by statistical means; the larger the tissue biopsies, the smaller was the coefficient of variation. The skewness of the activity distributions increased with decreasing biopsy mass. Conclusions The tissue activity distributions in normal tissue were heterogeneous on a relevant geometric scale considering the range of the ionising electrons. 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Heterogeneity of microsphere distribution in resected liver and tumour tissue following selective intrahepatic radiotherapy

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