Mitochondrial pathway mediated apoptosis and cell cycle arrest triggered by aqueous extract of wheatgrass in colon cancer colo-205 cells

Abstract Four different extracts of wheatgrass i.e. hexane, chloroform, methanol and aqueous were used to evaluate the anti-cancer potential on COLO-205 cells. Aqueous extract demonstrated maximum anti-cancer activities with significant inhibition on growth of COLO-205 cells. Anti-proliferative capa...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Arora, Shagun [verfasserIn] Tandon, Simran [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Wheatgrass Cytoxicity Anti-proliferation Migration Apoptosis and cell cycle

Übergeordnetes Werk:	Enthalten in: Journal of plant biochemistry and biotechnology - Berlin : Springer, 1992, 25(2015), 1 vom: 14. Mai, Seite 56-63
Übergeordnetes Werk:	volume:25 ; year:2015 ; number:1 ; day:14 ; month:05 ; pages:56-63

Links:	Volltext

DOI / URN:	10.1007/s13562-015-0309-7

Katalog-ID:	SPR031803571

Internformat


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520			\|a Abstract Four different extracts of wheatgrass i.e. hexane, chloroform, methanol and aqueous were used to evaluate the anti-cancer potential on COLO-205 cells. Aqueous extract demonstrated maximum anti-cancer activities with significant inhibition on growth of COLO-205 cells. Anti-proliferative capabilities were also enhanced, as observed from clonogenic survival and in vitro wound scratch assay. Increased apoptotic hallmarks were evidenced in aqueous extract treated cells such as, DNA fragmentation, nuclear condensation and membrane blebbing. Increased expression of caspase-9, caspase-3 and Bax genes, along with down-regulation of Bcl-2 gene was also seen. Arrest of cells at $ G_{0} $/G1 phase by flow cytometric analysis could be attributed to up-regulated expression of inhibitors of cell cycle progression i.e. p16, p21 and p27 in aqueous extract treated cells. GC analysis revealed the presence of various chemicals possessing medicinal properties which could be responsible for the effects seen on the cancer cells. Our findings, for the first time suggest that the aqueous extract of wheatgrass represents a potential plant based anti-cancer agent.
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matchkey_str	article:09741275:2015----::iohnraptwyeitdppoiadelylarstigrdyqeuetatfha
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allfields	10.1007/s13562-015-0309-7 doi (DE-627)SPR031803571 (SPR)s13562-015-0309-7-e DE-627 ger DE-627 rakwb eng 540 570 ASE Arora, Shagun verfasserin aut Mitochondrial pathway mediated apoptosis and cell cycle arrest triggered by aqueous extract of wheatgrass in colon cancer colo-205 cells 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Four different extracts of wheatgrass i.e. hexane, chloroform, methanol and aqueous were used to evaluate the anti-cancer potential on COLO-205 cells. Aqueous extract demonstrated maximum anti-cancer activities with significant inhibition on growth of COLO-205 cells. Anti-proliferative capabilities were also enhanced, as observed from clonogenic survival and in vitro wound scratch assay. Increased apoptotic hallmarks were evidenced in aqueous extract treated cells such as, DNA fragmentation, nuclear condensation and membrane blebbing. Increased expression of caspase-9, caspase-3 and Bax genes, along with down-regulation of Bcl-2 gene was also seen. Arrest of cells at $ G_{0} $/G1 phase by flow cytometric analysis could be attributed to up-regulated expression of inhibitors of cell cycle progression i.e. p16, p21 and p27 in aqueous extract treated cells. GC analysis revealed the presence of various chemicals possessing medicinal properties which could be responsible for the effects seen on the cancer cells. Our findings, for the first time suggest that the aqueous extract of wheatgrass represents a potential plant based anti-cancer agent. Wheatgrass (dpeaa)DE-He213 Cytoxicity (dpeaa)DE-He213 Anti-proliferation (dpeaa)DE-He213 Migration (dpeaa)DE-He213 Apoptosis and cell cycle (dpeaa)DE-He213 Tandon, Simran verfasserin aut Enthalten in Journal of plant biochemistry and biotechnology Berlin : Springer, 1992 25(2015), 1 vom: 14. Mai, Seite 56-63 (DE-627)501417192 (DE-600)2206337-7 0974-1275 nnns volume:25 year:2015 number:1 day:14 month:05 pages:56-63 https://dx.doi.org/10.1007/s13562-015-0309-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 25 2015 1 14 05 56-63
spelling	10.1007/s13562-015-0309-7 doi (DE-627)SPR031803571 (SPR)s13562-015-0309-7-e DE-627 ger DE-627 rakwb eng 540 570 ASE Arora, Shagun verfasserin aut Mitochondrial pathway mediated apoptosis and cell cycle arrest triggered by aqueous extract of wheatgrass in colon cancer colo-205 cells 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Four different extracts of wheatgrass i.e. hexane, chloroform, methanol and aqueous were used to evaluate the anti-cancer potential on COLO-205 cells. Aqueous extract demonstrated maximum anti-cancer activities with significant inhibition on growth of COLO-205 cells. Anti-proliferative capabilities were also enhanced, as observed from clonogenic survival and in vitro wound scratch assay. Increased apoptotic hallmarks were evidenced in aqueous extract treated cells such as, DNA fragmentation, nuclear condensation and membrane blebbing. Increased expression of caspase-9, caspase-3 and Bax genes, along with down-regulation of Bcl-2 gene was also seen. Arrest of cells at $ G_{0} $/G1 phase by flow cytometric analysis could be attributed to up-regulated expression of inhibitors of cell cycle progression i.e. p16, p21 and p27 in aqueous extract treated cells. GC analysis revealed the presence of various chemicals possessing medicinal properties which could be responsible for the effects seen on the cancer cells. Our findings, for the first time suggest that the aqueous extract of wheatgrass represents a potential plant based anti-cancer agent. Wheatgrass (dpeaa)DE-He213 Cytoxicity (dpeaa)DE-He213 Anti-proliferation (dpeaa)DE-He213 Migration (dpeaa)DE-He213 Apoptosis and cell cycle (dpeaa)DE-He213 Tandon, Simran verfasserin aut Enthalten in Journal of plant biochemistry and biotechnology Berlin : Springer, 1992 25(2015), 1 vom: 14. Mai, Seite 56-63 (DE-627)501417192 (DE-600)2206337-7 0974-1275 nnns volume:25 year:2015 number:1 day:14 month:05 pages:56-63 https://dx.doi.org/10.1007/s13562-015-0309-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 25 2015 1 14 05 56-63
allfields_unstemmed	10.1007/s13562-015-0309-7 doi (DE-627)SPR031803571 (SPR)s13562-015-0309-7-e DE-627 ger DE-627 rakwb eng 540 570 ASE Arora, Shagun verfasserin aut Mitochondrial pathway mediated apoptosis and cell cycle arrest triggered by aqueous extract of wheatgrass in colon cancer colo-205 cells 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Four different extracts of wheatgrass i.e. hexane, chloroform, methanol and aqueous were used to evaluate the anti-cancer potential on COLO-205 cells. Aqueous extract demonstrated maximum anti-cancer activities with significant inhibition on growth of COLO-205 cells. Anti-proliferative capabilities were also enhanced, as observed from clonogenic survival and in vitro wound scratch assay. Increased apoptotic hallmarks were evidenced in aqueous extract treated cells such as, DNA fragmentation, nuclear condensation and membrane blebbing. Increased expression of caspase-9, caspase-3 and Bax genes, along with down-regulation of Bcl-2 gene was also seen. Arrest of cells at $ G_{0} $/G1 phase by flow cytometric analysis could be attributed to up-regulated expression of inhibitors of cell cycle progression i.e. p16, p21 and p27 in aqueous extract treated cells. GC analysis revealed the presence of various chemicals possessing medicinal properties which could be responsible for the effects seen on the cancer cells. Our findings, for the first time suggest that the aqueous extract of wheatgrass represents a potential plant based anti-cancer agent. Wheatgrass (dpeaa)DE-He213 Cytoxicity (dpeaa)DE-He213 Anti-proliferation (dpeaa)DE-He213 Migration (dpeaa)DE-He213 Apoptosis and cell cycle (dpeaa)DE-He213 Tandon, Simran verfasserin aut Enthalten in Journal of plant biochemistry and biotechnology Berlin : Springer, 1992 25(2015), 1 vom: 14. Mai, Seite 56-63 (DE-627)501417192 (DE-600)2206337-7 0974-1275 nnns volume:25 year:2015 number:1 day:14 month:05 pages:56-63 https://dx.doi.org/10.1007/s13562-015-0309-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 25 2015 1 14 05 56-63
allfieldsGer	10.1007/s13562-015-0309-7 doi (DE-627)SPR031803571 (SPR)s13562-015-0309-7-e DE-627 ger DE-627 rakwb eng 540 570 ASE Arora, Shagun verfasserin aut Mitochondrial pathway mediated apoptosis and cell cycle arrest triggered by aqueous extract of wheatgrass in colon cancer colo-205 cells 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Four different extracts of wheatgrass i.e. hexane, chloroform, methanol and aqueous were used to evaluate the anti-cancer potential on COLO-205 cells. Aqueous extract demonstrated maximum anti-cancer activities with significant inhibition on growth of COLO-205 cells. Anti-proliferative capabilities were also enhanced, as observed from clonogenic survival and in vitro wound scratch assay. Increased apoptotic hallmarks were evidenced in aqueous extract treated cells such as, DNA fragmentation, nuclear condensation and membrane blebbing. Increased expression of caspase-9, caspase-3 and Bax genes, along with down-regulation of Bcl-2 gene was also seen. Arrest of cells at $ G_{0} $/G1 phase by flow cytometric analysis could be attributed to up-regulated expression of inhibitors of cell cycle progression i.e. p16, p21 and p27 in aqueous extract treated cells. GC analysis revealed the presence of various chemicals possessing medicinal properties which could be responsible for the effects seen on the cancer cells. Our findings, for the first time suggest that the aqueous extract of wheatgrass represents a potential plant based anti-cancer agent. Wheatgrass (dpeaa)DE-He213 Cytoxicity (dpeaa)DE-He213 Anti-proliferation (dpeaa)DE-He213 Migration (dpeaa)DE-He213 Apoptosis and cell cycle (dpeaa)DE-He213 Tandon, Simran verfasserin aut Enthalten in Journal of plant biochemistry and biotechnology Berlin : Springer, 1992 25(2015), 1 vom: 14. Mai, Seite 56-63 (DE-627)501417192 (DE-600)2206337-7 0974-1275 nnns volume:25 year:2015 number:1 day:14 month:05 pages:56-63 https://dx.doi.org/10.1007/s13562-015-0309-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 25 2015 1 14 05 56-63
allfieldsSound	10.1007/s13562-015-0309-7 doi (DE-627)SPR031803571 (SPR)s13562-015-0309-7-e DE-627 ger DE-627 rakwb eng 540 570 ASE Arora, Shagun verfasserin aut Mitochondrial pathway mediated apoptosis and cell cycle arrest triggered by aqueous extract of wheatgrass in colon cancer colo-205 cells 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Four different extracts of wheatgrass i.e. hexane, chloroform, methanol and aqueous were used to evaluate the anti-cancer potential on COLO-205 cells. Aqueous extract demonstrated maximum anti-cancer activities with significant inhibition on growth of COLO-205 cells. Anti-proliferative capabilities were also enhanced, as observed from clonogenic survival and in vitro wound scratch assay. Increased apoptotic hallmarks were evidenced in aqueous extract treated cells such as, DNA fragmentation, nuclear condensation and membrane blebbing. Increased expression of caspase-9, caspase-3 and Bax genes, along with down-regulation of Bcl-2 gene was also seen. Arrest of cells at $ G_{0} $/G1 phase by flow cytometric analysis could be attributed to up-regulated expression of inhibitors of cell cycle progression i.e. p16, p21 and p27 in aqueous extract treated cells. GC analysis revealed the presence of various chemicals possessing medicinal properties which could be responsible for the effects seen on the cancer cells. Our findings, for the first time suggest that the aqueous extract of wheatgrass represents a potential plant based anti-cancer agent. Wheatgrass (dpeaa)DE-He213 Cytoxicity (dpeaa)DE-He213 Anti-proliferation (dpeaa)DE-He213 Migration (dpeaa)DE-He213 Apoptosis and cell cycle (dpeaa)DE-He213 Tandon, Simran verfasserin aut Enthalten in Journal of plant biochemistry and biotechnology Berlin : Springer, 1992 25(2015), 1 vom: 14. Mai, Seite 56-63 (DE-627)501417192 (DE-600)2206337-7 0974-1275 nnns volume:25 year:2015 number:1 day:14 month:05 pages:56-63 https://dx.doi.org/10.1007/s13562-015-0309-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 25 2015 1 14 05 56-63
language	English
source	Enthalten in Journal of plant biochemistry and biotechnology 25(2015), 1 vom: 14. Mai, Seite 56-63 volume:25 year:2015 number:1 day:14 month:05 pages:56-63
sourceStr	Enthalten in Journal of plant biochemistry and biotechnology 25(2015), 1 vom: 14. Mai, Seite 56-63 volume:25 year:2015 number:1 day:14 month:05 pages:56-63
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Wheatgrass Cytoxicity Anti-proliferation Migration Apoptosis and cell cycle
dewey-raw	540
isfreeaccess_bool	false
container_title	Journal of plant biochemistry and biotechnology
authorswithroles_txt_mv	Arora, Shagun @@aut@@ Tandon, Simran @@aut@@
publishDateDaySort_date	2015-05-14T00:00:00Z
hierarchy_top_id	501417192
dewey-sort	3540
id	SPR031803571
language_de	englisch
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author	Arora, Shagun
spellingShingle	Arora, Shagun ddc 540 misc Wheatgrass misc Cytoxicity misc Anti-proliferation misc Migration misc Apoptosis and cell cycle Mitochondrial pathway mediated apoptosis and cell cycle arrest triggered by aqueous extract of wheatgrass in colon cancer colo-205 cells
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topic_title	540 570 ASE Mitochondrial pathway mediated apoptosis and cell cycle arrest triggered by aqueous extract of wheatgrass in colon cancer colo-205 cells Wheatgrass (dpeaa)DE-He213 Cytoxicity (dpeaa)DE-He213 Anti-proliferation (dpeaa)DE-He213 Migration (dpeaa)DE-He213 Apoptosis and cell cycle (dpeaa)DE-He213
topic	ddc 540 misc Wheatgrass misc Cytoxicity misc Anti-proliferation misc Migration misc Apoptosis and cell cycle
topic_unstemmed	ddc 540 misc Wheatgrass misc Cytoxicity misc Anti-proliferation misc Migration misc Apoptosis and cell cycle
topic_browse	ddc 540 misc Wheatgrass misc Cytoxicity misc Anti-proliferation misc Migration misc Apoptosis and cell cycle
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title	Mitochondrial pathway mediated apoptosis and cell cycle arrest triggered by aqueous extract of wheatgrass in colon cancer colo-205 cells
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title_full	Mitochondrial pathway mediated apoptosis and cell cycle arrest triggered by aqueous extract of wheatgrass in colon cancer colo-205 cells
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title_sort	mitochondrial pathway mediated apoptosis and cell cycle arrest triggered by aqueous extract of wheatgrass in colon cancer colo-205 cells
title_auth	Mitochondrial pathway mediated apoptosis and cell cycle arrest triggered by aqueous extract of wheatgrass in colon cancer colo-205 cells
abstract	Abstract Four different extracts of wheatgrass i.e. hexane, chloroform, methanol and aqueous were used to evaluate the anti-cancer potential on COLO-205 cells. Aqueous extract demonstrated maximum anti-cancer activities with significant inhibition on growth of COLO-205 cells. Anti-proliferative capabilities were also enhanced, as observed from clonogenic survival and in vitro wound scratch assay. Increased apoptotic hallmarks were evidenced in aqueous extract treated cells such as, DNA fragmentation, nuclear condensation and membrane blebbing. Increased expression of caspase-9, caspase-3 and Bax genes, along with down-regulation of Bcl-2 gene was also seen. Arrest of cells at $ G_{0} $/G1 phase by flow cytometric analysis could be attributed to up-regulated expression of inhibitors of cell cycle progression i.e. p16, p21 and p27 in aqueous extract treated cells. GC analysis revealed the presence of various chemicals possessing medicinal properties which could be responsible for the effects seen on the cancer cells. Our findings, for the first time suggest that the aqueous extract of wheatgrass represents a potential plant based anti-cancer agent.
abstractGer	Abstract Four different extracts of wheatgrass i.e. hexane, chloroform, methanol and aqueous were used to evaluate the anti-cancer potential on COLO-205 cells. Aqueous extract demonstrated maximum anti-cancer activities with significant inhibition on growth of COLO-205 cells. Anti-proliferative capabilities were also enhanced, as observed from clonogenic survival and in vitro wound scratch assay. Increased apoptotic hallmarks were evidenced in aqueous extract treated cells such as, DNA fragmentation, nuclear condensation and membrane blebbing. Increased expression of caspase-9, caspase-3 and Bax genes, along with down-regulation of Bcl-2 gene was also seen. Arrest of cells at $ G_{0} $/G1 phase by flow cytometric analysis could be attributed to up-regulated expression of inhibitors of cell cycle progression i.e. p16, p21 and p27 in aqueous extract treated cells. GC analysis revealed the presence of various chemicals possessing medicinal properties which could be responsible for the effects seen on the cancer cells. Our findings, for the first time suggest that the aqueous extract of wheatgrass represents a potential plant based anti-cancer agent.
abstract_unstemmed	Abstract Four different extracts of wheatgrass i.e. hexane, chloroform, methanol and aqueous were used to evaluate the anti-cancer potential on COLO-205 cells. Aqueous extract demonstrated maximum anti-cancer activities with significant inhibition on growth of COLO-205 cells. Anti-proliferative capabilities were also enhanced, as observed from clonogenic survival and in vitro wound scratch assay. Increased apoptotic hallmarks were evidenced in aqueous extract treated cells such as, DNA fragmentation, nuclear condensation and membrane blebbing. Increased expression of caspase-9, caspase-3 and Bax genes, along with down-regulation of Bcl-2 gene was also seen. Arrest of cells at $ G_{0} $/G1 phase by flow cytometric analysis could be attributed to up-regulated expression of inhibitors of cell cycle progression i.e. p16, p21 and p27 in aqueous extract treated cells. GC analysis revealed the presence of various chemicals possessing medicinal properties which could be responsible for the effects seen on the cancer cells. Our findings, for the first time suggest that the aqueous extract of wheatgrass represents a potential plant based anti-cancer agent.
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container_issue	1
title_short	Mitochondrial pathway mediated apoptosis and cell cycle arrest triggered by aqueous extract of wheatgrass in colon cancer colo-205 cells
url	https://dx.doi.org/10.1007/s13562-015-0309-7
remote_bool	true
author2	Tandon, Simran
author2Str	Tandon, Simran
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doi_str	10.1007/s13562-015-0309-7
up_date	2024-07-04T01:18:35.998Z
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Mitochondrial pathway mediated apoptosis and cell cycle arrest triggered by aqueous extract of wheatgrass in colon cancer colo-205 cells

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