Combining radiotherapy and immunotherapy for prostate cancer: two decades of research from preclinical to clinical trials

Abstract The combination of radiation therapy and immunotherapy is a novel therapeutic approach for prostate cancer. Preclinical evidence has shown that ionizing radiation can have immunostimulatory effects. Ionizing radiation can also affect the tumor microenvironment, enhance infiltration of activ...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Huang, Ying [verfasserIn] Chen, Wei [verfasserIn] Teh, Bin S. [verfasserIn] Butler, E. Brian [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Radiotherapy Immunotherapy Abscopal effect Prostate cancer

Übergeordnetes Werk:	Enthalten in: Journal of radiation oncology - Berlin : Springer, 2012, 4(2015), 4 vom: Dez., Seite 365-375
Übergeordnetes Werk:	volume:4 ; year:2015 ; number:4 ; month:12 ; pages:365-375

Links:	Volltext

DOI / URN:	10.1007/s13566-015-0240-5

Katalog-ID:	SPR031811566

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allfields	10.1007/s13566-015-0240-5 doi (DE-627)SPR031811566 (SPR)s13566-015-0240-5-e DE-627 ger DE-627 rakwb eng 610 ASE Huang, Ying verfasserin aut Combining radiotherapy and immunotherapy for prostate cancer: two decades of research from preclinical to clinical trials 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The combination of radiation therapy and immunotherapy is a novel therapeutic approach for prostate cancer. Preclinical evidence has shown that ionizing radiation can have immunostimulatory effects. Ionizing radiation can also affect the tumor microenvironment, enhance infiltration of activated T cells, and trigger an inflammatory process. Together, the combined radio-immunotherapy can enhance cancer cell kill and stimulate the host immune system, providing improved local and systemic control as well as prolongation of survival. The goal of combining radiation therapy with immunotherapy is also to improve cancer cure without an increase in treatment-related toxicity. The combined approach offers a new paradigm, whereby two local therapies, i.e., radiotherapy and in situ immunotherapy, are combined to elicit both local and systemic effects. Herein, we review the rationale for combining radiation and different immunotherapies, the interactions between tumors and the immune system, as well as immunological and abscopal effects of ionizing radiation. The preclinical and clinical trials of combined radiation therapy and immunotherapy for prostate cancer are reviewed. This combined approach holds promise in the management of prostate cancer. Radiotherapy (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 Abscopal effect (dpeaa)DE-He213 Prostate cancer (dpeaa)DE-He213 Chen, Wei verfasserin aut Teh, Bin S. verfasserin aut Butler, E. Brian verfasserin aut Enthalten in Journal of radiation oncology Berlin : Springer, 2012 4(2015), 4 vom: Dez., Seite 365-375 (DE-627)718611233 (DE-600)2660511-9 1948-7908 nnns volume:4 year:2015 number:4 month:12 pages:365-375 https://dx.doi.org/10.1007/s13566-015-0240-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 4 2015 4 12 365-375
spelling	10.1007/s13566-015-0240-5 doi (DE-627)SPR031811566 (SPR)s13566-015-0240-5-e DE-627 ger DE-627 rakwb eng 610 ASE Huang, Ying verfasserin aut Combining radiotherapy and immunotherapy for prostate cancer: two decades of research from preclinical to clinical trials 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The combination of radiation therapy and immunotherapy is a novel therapeutic approach for prostate cancer. Preclinical evidence has shown that ionizing radiation can have immunostimulatory effects. Ionizing radiation can also affect the tumor microenvironment, enhance infiltration of activated T cells, and trigger an inflammatory process. Together, the combined radio-immunotherapy can enhance cancer cell kill and stimulate the host immune system, providing improved local and systemic control as well as prolongation of survival. The goal of combining radiation therapy with immunotherapy is also to improve cancer cure without an increase in treatment-related toxicity. The combined approach offers a new paradigm, whereby two local therapies, i.e., radiotherapy and in situ immunotherapy, are combined to elicit both local and systemic effects. Herein, we review the rationale for combining radiation and different immunotherapies, the interactions between tumors and the immune system, as well as immunological and abscopal effects of ionizing radiation. The preclinical and clinical trials of combined radiation therapy and immunotherapy for prostate cancer are reviewed. This combined approach holds promise in the management of prostate cancer. Radiotherapy (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 Abscopal effect (dpeaa)DE-He213 Prostate cancer (dpeaa)DE-He213 Chen, Wei verfasserin aut Teh, Bin S. verfasserin aut Butler, E. Brian verfasserin aut Enthalten in Journal of radiation oncology Berlin : Springer, 2012 4(2015), 4 vom: Dez., Seite 365-375 (DE-627)718611233 (DE-600)2660511-9 1948-7908 nnns volume:4 year:2015 number:4 month:12 pages:365-375 https://dx.doi.org/10.1007/s13566-015-0240-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 4 2015 4 12 365-375
allfields_unstemmed	10.1007/s13566-015-0240-5 doi (DE-627)SPR031811566 (SPR)s13566-015-0240-5-e DE-627 ger DE-627 rakwb eng 610 ASE Huang, Ying verfasserin aut Combining radiotherapy and immunotherapy for prostate cancer: two decades of research from preclinical to clinical trials 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The combination of radiation therapy and immunotherapy is a novel therapeutic approach for prostate cancer. Preclinical evidence has shown that ionizing radiation can have immunostimulatory effects. Ionizing radiation can also affect the tumor microenvironment, enhance infiltration of activated T cells, and trigger an inflammatory process. Together, the combined radio-immunotherapy can enhance cancer cell kill and stimulate the host immune system, providing improved local and systemic control as well as prolongation of survival. The goal of combining radiation therapy with immunotherapy is also to improve cancer cure without an increase in treatment-related toxicity. The combined approach offers a new paradigm, whereby two local therapies, i.e., radiotherapy and in situ immunotherapy, are combined to elicit both local and systemic effects. Herein, we review the rationale for combining radiation and different immunotherapies, the interactions between tumors and the immune system, as well as immunological and abscopal effects of ionizing radiation. The preclinical and clinical trials of combined radiation therapy and immunotherapy for prostate cancer are reviewed. This combined approach holds promise in the management of prostate cancer. Radiotherapy (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 Abscopal effect (dpeaa)DE-He213 Prostate cancer (dpeaa)DE-He213 Chen, Wei verfasserin aut Teh, Bin S. verfasserin aut Butler, E. Brian verfasserin aut Enthalten in Journal of radiation oncology Berlin : Springer, 2012 4(2015), 4 vom: Dez., Seite 365-375 (DE-627)718611233 (DE-600)2660511-9 1948-7908 nnns volume:4 year:2015 number:4 month:12 pages:365-375 https://dx.doi.org/10.1007/s13566-015-0240-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 4 2015 4 12 365-375
allfieldsGer	10.1007/s13566-015-0240-5 doi (DE-627)SPR031811566 (SPR)s13566-015-0240-5-e DE-627 ger DE-627 rakwb eng 610 ASE Huang, Ying verfasserin aut Combining radiotherapy and immunotherapy for prostate cancer: two decades of research from preclinical to clinical trials 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The combination of radiation therapy and immunotherapy is a novel therapeutic approach for prostate cancer. Preclinical evidence has shown that ionizing radiation can have immunostimulatory effects. Ionizing radiation can also affect the tumor microenvironment, enhance infiltration of activated T cells, and trigger an inflammatory process. Together, the combined radio-immunotherapy can enhance cancer cell kill and stimulate the host immune system, providing improved local and systemic control as well as prolongation of survival. The goal of combining radiation therapy with immunotherapy is also to improve cancer cure without an increase in treatment-related toxicity. The combined approach offers a new paradigm, whereby two local therapies, i.e., radiotherapy and in situ immunotherapy, are combined to elicit both local and systemic effects. Herein, we review the rationale for combining radiation and different immunotherapies, the interactions between tumors and the immune system, as well as immunological and abscopal effects of ionizing radiation. The preclinical and clinical trials of combined radiation therapy and immunotherapy for prostate cancer are reviewed. This combined approach holds promise in the management of prostate cancer. Radiotherapy (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 Abscopal effect (dpeaa)DE-He213 Prostate cancer (dpeaa)DE-He213 Chen, Wei verfasserin aut Teh, Bin S. verfasserin aut Butler, E. Brian verfasserin aut Enthalten in Journal of radiation oncology Berlin : Springer, 2012 4(2015), 4 vom: Dez., Seite 365-375 (DE-627)718611233 (DE-600)2660511-9 1948-7908 nnns volume:4 year:2015 number:4 month:12 pages:365-375 https://dx.doi.org/10.1007/s13566-015-0240-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 4 2015 4 12 365-375
allfieldsSound	10.1007/s13566-015-0240-5 doi (DE-627)SPR031811566 (SPR)s13566-015-0240-5-e DE-627 ger DE-627 rakwb eng 610 ASE Huang, Ying verfasserin aut Combining radiotherapy and immunotherapy for prostate cancer: two decades of research from preclinical to clinical trials 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The combination of radiation therapy and immunotherapy is a novel therapeutic approach for prostate cancer. Preclinical evidence has shown that ionizing radiation can have immunostimulatory effects. Ionizing radiation can also affect the tumor microenvironment, enhance infiltration of activated T cells, and trigger an inflammatory process. Together, the combined radio-immunotherapy can enhance cancer cell kill and stimulate the host immune system, providing improved local and systemic control as well as prolongation of survival. The goal of combining radiation therapy with immunotherapy is also to improve cancer cure without an increase in treatment-related toxicity. The combined approach offers a new paradigm, whereby two local therapies, i.e., radiotherapy and in situ immunotherapy, are combined to elicit both local and systemic effects. Herein, we review the rationale for combining radiation and different immunotherapies, the interactions between tumors and the immune system, as well as immunological and abscopal effects of ionizing radiation. The preclinical and clinical trials of combined radiation therapy and immunotherapy for prostate cancer are reviewed. This combined approach holds promise in the management of prostate cancer. Radiotherapy (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 Abscopal effect (dpeaa)DE-He213 Prostate cancer (dpeaa)DE-He213 Chen, Wei verfasserin aut Teh, Bin S. verfasserin aut Butler, E. Brian verfasserin aut Enthalten in Journal of radiation oncology Berlin : Springer, 2012 4(2015), 4 vom: Dez., Seite 365-375 (DE-627)718611233 (DE-600)2660511-9 1948-7908 nnns volume:4 year:2015 number:4 month:12 pages:365-375 https://dx.doi.org/10.1007/s13566-015-0240-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 4 2015 4 12 365-375
language	English
source	Enthalten in Journal of radiation oncology 4(2015), 4 vom: Dez., Seite 365-375 volume:4 year:2015 number:4 month:12 pages:365-375
sourceStr	Enthalten in Journal of radiation oncology 4(2015), 4 vom: Dez., Seite 365-375 volume:4 year:2015 number:4 month:12 pages:365-375
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Radiotherapy Immunotherapy Abscopal effect Prostate cancer
dewey-raw	610
isfreeaccess_bool	false
container_title	Journal of radiation oncology
authorswithroles_txt_mv	Huang, Ying @@aut@@ Chen, Wei @@aut@@ Teh, Bin S. @@aut@@ Butler, E. Brian @@aut@@
publishDateDaySort_date	2015-12-01T00:00:00Z
hierarchy_top_id	718611233
dewey-sort	3610
id	SPR031811566
language_de	englisch
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author	Huang, Ying
spellingShingle	Huang, Ying ddc 610 misc Radiotherapy misc Immunotherapy misc Abscopal effect misc Prostate cancer Combining radiotherapy and immunotherapy for prostate cancer: two decades of research from preclinical to clinical trials
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topic_title	610 ASE Combining radiotherapy and immunotherapy for prostate cancer: two decades of research from preclinical to clinical trials Radiotherapy (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 Abscopal effect (dpeaa)DE-He213 Prostate cancer (dpeaa)DE-He213
topic	ddc 610 misc Radiotherapy misc Immunotherapy misc Abscopal effect misc Prostate cancer
topic_unstemmed	ddc 610 misc Radiotherapy misc Immunotherapy misc Abscopal effect misc Prostate cancer
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title	Combining radiotherapy and immunotherapy for prostate cancer: two decades of research from preclinical to clinical trials
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title_full	Combining radiotherapy and immunotherapy for prostate cancer: two decades of research from preclinical to clinical trials
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author_browse	Huang, Ying Chen, Wei Teh, Bin S. Butler, E. Brian
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title_sort	combining radiotherapy and immunotherapy for prostate cancer: two decades of research from preclinical to clinical trials
title_auth	Combining radiotherapy and immunotherapy for prostate cancer: two decades of research from preclinical to clinical trials
abstract	Abstract The combination of radiation therapy and immunotherapy is a novel therapeutic approach for prostate cancer. Preclinical evidence has shown that ionizing radiation can have immunostimulatory effects. Ionizing radiation can also affect the tumor microenvironment, enhance infiltration of activated T cells, and trigger an inflammatory process. Together, the combined radio-immunotherapy can enhance cancer cell kill and stimulate the host immune system, providing improved local and systemic control as well as prolongation of survival. The goal of combining radiation therapy with immunotherapy is also to improve cancer cure without an increase in treatment-related toxicity. The combined approach offers a new paradigm, whereby two local therapies, i.e., radiotherapy and in situ immunotherapy, are combined to elicit both local and systemic effects. Herein, we review the rationale for combining radiation and different immunotherapies, the interactions between tumors and the immune system, as well as immunological and abscopal effects of ionizing radiation. The preclinical and clinical trials of combined radiation therapy and immunotherapy for prostate cancer are reviewed. This combined approach holds promise in the management of prostate cancer.
abstractGer	Abstract The combination of radiation therapy and immunotherapy is a novel therapeutic approach for prostate cancer. Preclinical evidence has shown that ionizing radiation can have immunostimulatory effects. Ionizing radiation can also affect the tumor microenvironment, enhance infiltration of activated T cells, and trigger an inflammatory process. Together, the combined radio-immunotherapy can enhance cancer cell kill and stimulate the host immune system, providing improved local and systemic control as well as prolongation of survival. The goal of combining radiation therapy with immunotherapy is also to improve cancer cure without an increase in treatment-related toxicity. The combined approach offers a new paradigm, whereby two local therapies, i.e., radiotherapy and in situ immunotherapy, are combined to elicit both local and systemic effects. Herein, we review the rationale for combining radiation and different immunotherapies, the interactions between tumors and the immune system, as well as immunological and abscopal effects of ionizing radiation. The preclinical and clinical trials of combined radiation therapy and immunotherapy for prostate cancer are reviewed. This combined approach holds promise in the management of prostate cancer.
abstract_unstemmed	Abstract The combination of radiation therapy and immunotherapy is a novel therapeutic approach for prostate cancer. Preclinical evidence has shown that ionizing radiation can have immunostimulatory effects. Ionizing radiation can also affect the tumor microenvironment, enhance infiltration of activated T cells, and trigger an inflammatory process. Together, the combined radio-immunotherapy can enhance cancer cell kill and stimulate the host immune system, providing improved local and systemic control as well as prolongation of survival. The goal of combining radiation therapy with immunotherapy is also to improve cancer cure without an increase in treatment-related toxicity. The combined approach offers a new paradigm, whereby two local therapies, i.e., radiotherapy and in situ immunotherapy, are combined to elicit both local and systemic effects. Herein, we review the rationale for combining radiation and different immunotherapies, the interactions between tumors and the immune system, as well as immunological and abscopal effects of ionizing radiation. The preclinical and clinical trials of combined radiation therapy and immunotherapy for prostate cancer are reviewed. This combined approach holds promise in the management of prostate cancer.
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title_short	Combining radiotherapy and immunotherapy for prostate cancer: two decades of research from preclinical to clinical trials
url	https://dx.doi.org/10.1007/s13566-015-0240-5
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author2	Chen, Wei Teh, Bin S. Butler, E. Brian
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doi_str	10.1007/s13566-015-0240-5
up_date	2024-07-04T01:20:48.475Z
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