Function preservation and optimal outcomes—definitive chemoradiotherapy with multi-phase treatment planning for locally advanced sinonasal cancer

Objectives The aim of this study is to review radiotherapy (RT) techniques and outcomes for definitive RT or chemoradiotherapy (CRT) for very locally advanced or unresectable sinonasal cancer (SNC) at a single institution. Methods Between 1998 and 2010, there were 11 patients with very locally advan...
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Autor*in:	Burt, Lindsay M. [verfasserIn] Orlandi, Richard R. [verfasserIn] Hunt, Jason P. [verfasserIn] Buchmann, Luke O. [verfasserIn] Grossman, Kenneth F. [verfasserIn] Monroe, Marcus M. [verfasserIn] Shrieve, Dennis C. [verfasserIn] Hitchcock, Ying J. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Radiation therapy treatment Definitive ChemoRT IMRT Parasinonasal cancer

Übergeordnetes Werk:	Enthalten in: Journal of radiation oncology - Berlin : Springer, 2012, 5(2015), 1 vom: 12. Nov., Seite 47-54
Übergeordnetes Werk:	volume:5 ; year:2015 ; number:1 ; day:12 ; month:11 ; pages:47-54

Links:	Volltext

DOI / URN:	10.1007/s13566-015-0226-3

Katalog-ID:	SPR031811655

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245	1	0	\|a Function preservation and optimal outcomes—definitive chemoradiotherapy with multi-phase treatment planning for locally advanced sinonasal cancer
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520			\|a Objectives The aim of this study is to review radiotherapy (RT) techniques and outcomes for definitive RT or chemoradiotherapy (CRT) for very locally advanced or unresectable sinonasal cancer (SNC) at a single institution. Methods Between 1998 and 2010, there were 11 patients with very locally advanced or unresectable SNCs treated with definitive CRT (8) and RT alone (3) at the University of Utah. CRT was given to stage IVA (5) and stage IVB (3) patients; RT alone was given to stage III (1) and stage IVA (2) patients. All patients were treated with intensity-modulated radiation therapy (IMRT). The median dose was 70.2 Gy (70–72.4 Gy). Most patients underwent two treatment planning phases in order to prevent critical structures from receiving a high dose due to tumor regression and weight loss. The most common chemotherapy was cisplatin 40 mg/$ m^{2} $ given on a weekly basis for 6–7 cycles. A flexible nasal endoscopy with a biopsy was performed 3 months posttreatment to evaluate tumor response. Results With a median follow-up of 41 months (2–114), overall local control was seen in 8 out of 11 (72.7 %) patients. There was 1 (9.1 %) regional recurrence and 2 (18.2 %) distant metastasis. The definitive CRT or RT was well tolerated with only 2 patients experiencing a grade 3 late toxicity. Conclusion Definitive CRT or RT is feasible for very locally advanced or unresectable SNC. Local control is encouraging with acceptable treatment-related complications when treating with the described two-phase IMRT treatment technique.
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650		4	\|a Parasinonasal cancer \|7 (dpeaa)DE-He213
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700	1		\|a Buchmann, Luke O. \|e verfasserin \|4 aut
700	1		\|a Grossman, Kenneth F. \|e verfasserin \|4 aut
700	1		\|a Monroe, Marcus M. \|e verfasserin \|4 aut
700	1		\|a Shrieve, Dennis C. \|e verfasserin \|4 aut
700	1		\|a Hitchcock, Ying J. \|e verfasserin \|4 aut
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allfields	10.1007/s13566-015-0226-3 doi (DE-627)SPR031811655 (SPR)s13566-015-0226-3-e DE-627 ger DE-627 rakwb eng 610 ASE Burt, Lindsay M. verfasserin aut Function preservation and optimal outcomes—definitive chemoradiotherapy with multi-phase treatment planning for locally advanced sinonasal cancer 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives The aim of this study is to review radiotherapy (RT) techniques and outcomes for definitive RT or chemoradiotherapy (CRT) for very locally advanced or unresectable sinonasal cancer (SNC) at a single institution. Methods Between 1998 and 2010, there were 11 patients with very locally advanced or unresectable SNCs treated with definitive CRT (8) and RT alone (3) at the University of Utah. CRT was given to stage IVA (5) and stage IVB (3) patients; RT alone was given to stage III (1) and stage IVA (2) patients. All patients were treated with intensity-modulated radiation therapy (IMRT). The median dose was 70.2 Gy (70–72.4 Gy). Most patients underwent two treatment planning phases in order to prevent critical structures from receiving a high dose due to tumor regression and weight loss. The most common chemotherapy was cisplatin 40 mg/$ m^{2} $ given on a weekly basis for 6–7 cycles. A flexible nasal endoscopy with a biopsy was performed 3 months posttreatment to evaluate tumor response. Results With a median follow-up of 41 months (2–114), overall local control was seen in 8 out of 11 (72.7 %) patients. There was 1 (9.1 %) regional recurrence and 2 (18.2 %) distant metastasis. The definitive CRT or RT was well tolerated with only 2 patients experiencing a grade 3 late toxicity. Conclusion Definitive CRT or RT is feasible for very locally advanced or unresectable SNC. Local control is encouraging with acceptable treatment-related complications when treating with the described two-phase IMRT treatment technique. Radiation therapy treatment (dpeaa)DE-He213 Definitive ChemoRT (dpeaa)DE-He213 IMRT (dpeaa)DE-He213 Parasinonasal cancer (dpeaa)DE-He213 Orlandi, Richard R. verfasserin aut Hunt, Jason P. verfasserin aut Buchmann, Luke O. verfasserin aut Grossman, Kenneth F. verfasserin aut Monroe, Marcus M. verfasserin aut Shrieve, Dennis C. verfasserin aut Hitchcock, Ying J. verfasserin aut Enthalten in Journal of radiation oncology Berlin : Springer, 2012 5(2015), 1 vom: 12. Nov., Seite 47-54 (DE-627)718611233 (DE-600)2660511-9 1948-7908 nnns volume:5 year:2015 number:1 day:12 month:11 pages:47-54 https://dx.doi.org/10.1007/s13566-015-0226-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 5 2015 1 12 11 47-54
spelling	10.1007/s13566-015-0226-3 doi (DE-627)SPR031811655 (SPR)s13566-015-0226-3-e DE-627 ger DE-627 rakwb eng 610 ASE Burt, Lindsay M. verfasserin aut Function preservation and optimal outcomes—definitive chemoradiotherapy with multi-phase treatment planning for locally advanced sinonasal cancer 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives The aim of this study is to review radiotherapy (RT) techniques and outcomes for definitive RT or chemoradiotherapy (CRT) for very locally advanced or unresectable sinonasal cancer (SNC) at a single institution. Methods Between 1998 and 2010, there were 11 patients with very locally advanced or unresectable SNCs treated with definitive CRT (8) and RT alone (3) at the University of Utah. CRT was given to stage IVA (5) and stage IVB (3) patients; RT alone was given to stage III (1) and stage IVA (2) patients. All patients were treated with intensity-modulated radiation therapy (IMRT). The median dose was 70.2 Gy (70–72.4 Gy). Most patients underwent two treatment planning phases in order to prevent critical structures from receiving a high dose due to tumor regression and weight loss. The most common chemotherapy was cisplatin 40 mg/$ m^{2} $ given on a weekly basis for 6–7 cycles. A flexible nasal endoscopy with a biopsy was performed 3 months posttreatment to evaluate tumor response. Results With a median follow-up of 41 months (2–114), overall local control was seen in 8 out of 11 (72.7 %) patients. There was 1 (9.1 %) regional recurrence and 2 (18.2 %) distant metastasis. The definitive CRT or RT was well tolerated with only 2 patients experiencing a grade 3 late toxicity. Conclusion Definitive CRT or RT is feasible for very locally advanced or unresectable SNC. Local control is encouraging with acceptable treatment-related complications when treating with the described two-phase IMRT treatment technique. Radiation therapy treatment (dpeaa)DE-He213 Definitive ChemoRT (dpeaa)DE-He213 IMRT (dpeaa)DE-He213 Parasinonasal cancer (dpeaa)DE-He213 Orlandi, Richard R. verfasserin aut Hunt, Jason P. verfasserin aut Buchmann, Luke O. verfasserin aut Grossman, Kenneth F. verfasserin aut Monroe, Marcus M. verfasserin aut Shrieve, Dennis C. verfasserin aut Hitchcock, Ying J. verfasserin aut Enthalten in Journal of radiation oncology Berlin : Springer, 2012 5(2015), 1 vom: 12. Nov., Seite 47-54 (DE-627)718611233 (DE-600)2660511-9 1948-7908 nnns volume:5 year:2015 number:1 day:12 month:11 pages:47-54 https://dx.doi.org/10.1007/s13566-015-0226-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 5 2015 1 12 11 47-54
allfields_unstemmed	10.1007/s13566-015-0226-3 doi (DE-627)SPR031811655 (SPR)s13566-015-0226-3-e DE-627 ger DE-627 rakwb eng 610 ASE Burt, Lindsay M. verfasserin aut Function preservation and optimal outcomes—definitive chemoradiotherapy with multi-phase treatment planning for locally advanced sinonasal cancer 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives The aim of this study is to review radiotherapy (RT) techniques and outcomes for definitive RT or chemoradiotherapy (CRT) for very locally advanced or unresectable sinonasal cancer (SNC) at a single institution. Methods Between 1998 and 2010, there were 11 patients with very locally advanced or unresectable SNCs treated with definitive CRT (8) and RT alone (3) at the University of Utah. CRT was given to stage IVA (5) and stage IVB (3) patients; RT alone was given to stage III (1) and stage IVA (2) patients. All patients were treated with intensity-modulated radiation therapy (IMRT). The median dose was 70.2 Gy (70–72.4 Gy). Most patients underwent two treatment planning phases in order to prevent critical structures from receiving a high dose due to tumor regression and weight loss. The most common chemotherapy was cisplatin 40 mg/$ m^{2} $ given on a weekly basis for 6–7 cycles. A flexible nasal endoscopy with a biopsy was performed 3 months posttreatment to evaluate tumor response. Results With a median follow-up of 41 months (2–114), overall local control was seen in 8 out of 11 (72.7 %) patients. There was 1 (9.1 %) regional recurrence and 2 (18.2 %) distant metastasis. The definitive CRT or RT was well tolerated with only 2 patients experiencing a grade 3 late toxicity. Conclusion Definitive CRT or RT is feasible for very locally advanced or unresectable SNC. Local control is encouraging with acceptable treatment-related complications when treating with the described two-phase IMRT treatment technique. Radiation therapy treatment (dpeaa)DE-He213 Definitive ChemoRT (dpeaa)DE-He213 IMRT (dpeaa)DE-He213 Parasinonasal cancer (dpeaa)DE-He213 Orlandi, Richard R. verfasserin aut Hunt, Jason P. verfasserin aut Buchmann, Luke O. verfasserin aut Grossman, Kenneth F. verfasserin aut Monroe, Marcus M. verfasserin aut Shrieve, Dennis C. verfasserin aut Hitchcock, Ying J. verfasserin aut Enthalten in Journal of radiation oncology Berlin : Springer, 2012 5(2015), 1 vom: 12. Nov., Seite 47-54 (DE-627)718611233 (DE-600)2660511-9 1948-7908 nnns volume:5 year:2015 number:1 day:12 month:11 pages:47-54 https://dx.doi.org/10.1007/s13566-015-0226-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 5 2015 1 12 11 47-54
allfieldsGer	10.1007/s13566-015-0226-3 doi (DE-627)SPR031811655 (SPR)s13566-015-0226-3-e DE-627 ger DE-627 rakwb eng 610 ASE Burt, Lindsay M. verfasserin aut Function preservation and optimal outcomes—definitive chemoradiotherapy with multi-phase treatment planning for locally advanced sinonasal cancer 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives The aim of this study is to review radiotherapy (RT) techniques and outcomes for definitive RT or chemoradiotherapy (CRT) for very locally advanced or unresectable sinonasal cancer (SNC) at a single institution. Methods Between 1998 and 2010, there were 11 patients with very locally advanced or unresectable SNCs treated with definitive CRT (8) and RT alone (3) at the University of Utah. CRT was given to stage IVA (5) and stage IVB (3) patients; RT alone was given to stage III (1) and stage IVA (2) patients. All patients were treated with intensity-modulated radiation therapy (IMRT). The median dose was 70.2 Gy (70–72.4 Gy). Most patients underwent two treatment planning phases in order to prevent critical structures from receiving a high dose due to tumor regression and weight loss. The most common chemotherapy was cisplatin 40 mg/$ m^{2} $ given on a weekly basis for 6–7 cycles. A flexible nasal endoscopy with a biopsy was performed 3 months posttreatment to evaluate tumor response. Results With a median follow-up of 41 months (2–114), overall local control was seen in 8 out of 11 (72.7 %) patients. There was 1 (9.1 %) regional recurrence and 2 (18.2 %) distant metastasis. The definitive CRT or RT was well tolerated with only 2 patients experiencing a grade 3 late toxicity. Conclusion Definitive CRT or RT is feasible for very locally advanced or unresectable SNC. Local control is encouraging with acceptable treatment-related complications when treating with the described two-phase IMRT treatment technique. Radiation therapy treatment (dpeaa)DE-He213 Definitive ChemoRT (dpeaa)DE-He213 IMRT (dpeaa)DE-He213 Parasinonasal cancer (dpeaa)DE-He213 Orlandi, Richard R. verfasserin aut Hunt, Jason P. verfasserin aut Buchmann, Luke O. verfasserin aut Grossman, Kenneth F. verfasserin aut Monroe, Marcus M. verfasserin aut Shrieve, Dennis C. verfasserin aut Hitchcock, Ying J. verfasserin aut Enthalten in Journal of radiation oncology Berlin : Springer, 2012 5(2015), 1 vom: 12. Nov., Seite 47-54 (DE-627)718611233 (DE-600)2660511-9 1948-7908 nnns volume:5 year:2015 number:1 day:12 month:11 pages:47-54 https://dx.doi.org/10.1007/s13566-015-0226-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 5 2015 1 12 11 47-54
allfieldsSound	10.1007/s13566-015-0226-3 doi (DE-627)SPR031811655 (SPR)s13566-015-0226-3-e DE-627 ger DE-627 rakwb eng 610 ASE Burt, Lindsay M. verfasserin aut Function preservation and optimal outcomes—definitive chemoradiotherapy with multi-phase treatment planning for locally advanced sinonasal cancer 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives The aim of this study is to review radiotherapy (RT) techniques and outcomes for definitive RT or chemoradiotherapy (CRT) for very locally advanced or unresectable sinonasal cancer (SNC) at a single institution. Methods Between 1998 and 2010, there were 11 patients with very locally advanced or unresectable SNCs treated with definitive CRT (8) and RT alone (3) at the University of Utah. CRT was given to stage IVA (5) and stage IVB (3) patients; RT alone was given to stage III (1) and stage IVA (2) patients. All patients were treated with intensity-modulated radiation therapy (IMRT). The median dose was 70.2 Gy (70–72.4 Gy). Most patients underwent two treatment planning phases in order to prevent critical structures from receiving a high dose due to tumor regression and weight loss. The most common chemotherapy was cisplatin 40 mg/$ m^{2} $ given on a weekly basis for 6–7 cycles. A flexible nasal endoscopy with a biopsy was performed 3 months posttreatment to evaluate tumor response. Results With a median follow-up of 41 months (2–114), overall local control was seen in 8 out of 11 (72.7 %) patients. There was 1 (9.1 %) regional recurrence and 2 (18.2 %) distant metastasis. The definitive CRT or RT was well tolerated with only 2 patients experiencing a grade 3 late toxicity. Conclusion Definitive CRT or RT is feasible for very locally advanced or unresectable SNC. Local control is encouraging with acceptable treatment-related complications when treating with the described two-phase IMRT treatment technique. Radiation therapy treatment (dpeaa)DE-He213 Definitive ChemoRT (dpeaa)DE-He213 IMRT (dpeaa)DE-He213 Parasinonasal cancer (dpeaa)DE-He213 Orlandi, Richard R. verfasserin aut Hunt, Jason P. verfasserin aut Buchmann, Luke O. verfasserin aut Grossman, Kenneth F. verfasserin aut Monroe, Marcus M. verfasserin aut Shrieve, Dennis C. verfasserin aut Hitchcock, Ying J. verfasserin aut Enthalten in Journal of radiation oncology Berlin : Springer, 2012 5(2015), 1 vom: 12. Nov., Seite 47-54 (DE-627)718611233 (DE-600)2660511-9 1948-7908 nnns volume:5 year:2015 number:1 day:12 month:11 pages:47-54 https://dx.doi.org/10.1007/s13566-015-0226-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 5 2015 1 12 11 47-54
language	English
source	Enthalten in Journal of radiation oncology 5(2015), 1 vom: 12. Nov., Seite 47-54 volume:5 year:2015 number:1 day:12 month:11 pages:47-54
sourceStr	Enthalten in Journal of radiation oncology 5(2015), 1 vom: 12. Nov., Seite 47-54 volume:5 year:2015 number:1 day:12 month:11 pages:47-54
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Radiation therapy treatment Definitive ChemoRT IMRT Parasinonasal cancer
dewey-raw	610
isfreeaccess_bool	false
container_title	Journal of radiation oncology
authorswithroles_txt_mv	Burt, Lindsay M. @@aut@@ Orlandi, Richard R. @@aut@@ Hunt, Jason P. @@aut@@ Buchmann, Luke O. @@aut@@ Grossman, Kenneth F. @@aut@@ Monroe, Marcus M. @@aut@@ Shrieve, Dennis C. @@aut@@ Hitchcock, Ying J. @@aut@@
publishDateDaySort_date	2015-11-12T00:00:00Z
hierarchy_top_id	718611233
dewey-sort	3610
id	SPR031811655
language_de	englisch
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author	Burt, Lindsay M.
spellingShingle	Burt, Lindsay M. ddc 610 misc Radiation therapy treatment misc Definitive ChemoRT misc IMRT misc Parasinonasal cancer Function preservation and optimal outcomes—definitive chemoradiotherapy with multi-phase treatment planning for locally advanced sinonasal cancer
authorStr	Burt, Lindsay M.
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topic_title	610 ASE Function preservation and optimal outcomes—definitive chemoradiotherapy with multi-phase treatment planning for locally advanced sinonasal cancer Radiation therapy treatment (dpeaa)DE-He213 Definitive ChemoRT (dpeaa)DE-He213 IMRT (dpeaa)DE-He213 Parasinonasal cancer (dpeaa)DE-He213
topic	ddc 610 misc Radiation therapy treatment misc Definitive ChemoRT misc IMRT misc Parasinonasal cancer
topic_unstemmed	ddc 610 misc Radiation therapy treatment misc Definitive ChemoRT misc IMRT misc Parasinonasal cancer
topic_browse	ddc 610 misc Radiation therapy treatment misc Definitive ChemoRT misc IMRT misc Parasinonasal cancer
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title	Function preservation and optimal outcomes—definitive chemoradiotherapy with multi-phase treatment planning for locally advanced sinonasal cancer
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title_full	Function preservation and optimal outcomes—definitive chemoradiotherapy with multi-phase treatment planning for locally advanced sinonasal cancer
author_sort	Burt, Lindsay M.
journal	Journal of radiation oncology
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author_browse	Burt, Lindsay M. Orlandi, Richard R. Hunt, Jason P. Buchmann, Luke O. Grossman, Kenneth F. Monroe, Marcus M. Shrieve, Dennis C. Hitchcock, Ying J.
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class	610 ASE
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author-letter	Burt, Lindsay M.
doi_str_mv	10.1007/s13566-015-0226-3
dewey-full	610
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title_sort	function preservation and optimal outcomes—definitive chemoradiotherapy with multi-phase treatment planning for locally advanced sinonasal cancer
title_auth	Function preservation and optimal outcomes—definitive chemoradiotherapy with multi-phase treatment planning for locally advanced sinonasal cancer
abstract	Objectives The aim of this study is to review radiotherapy (RT) techniques and outcomes for definitive RT or chemoradiotherapy (CRT) for very locally advanced or unresectable sinonasal cancer (SNC) at a single institution. Methods Between 1998 and 2010, there were 11 patients with very locally advanced or unresectable SNCs treated with definitive CRT (8) and RT alone (3) at the University of Utah. CRT was given to stage IVA (5) and stage IVB (3) patients; RT alone was given to stage III (1) and stage IVA (2) patients. All patients were treated with intensity-modulated radiation therapy (IMRT). The median dose was 70.2 Gy (70–72.4 Gy). Most patients underwent two treatment planning phases in order to prevent critical structures from receiving a high dose due to tumor regression and weight loss. The most common chemotherapy was cisplatin 40 mg/$ m^{2} $ given on a weekly basis for 6–7 cycles. A flexible nasal endoscopy with a biopsy was performed 3 months posttreatment to evaluate tumor response. Results With a median follow-up of 41 months (2–114), overall local control was seen in 8 out of 11 (72.7 %) patients. There was 1 (9.1 %) regional recurrence and 2 (18.2 %) distant metastasis. The definitive CRT or RT was well tolerated with only 2 patients experiencing a grade 3 late toxicity. Conclusion Definitive CRT or RT is feasible for very locally advanced or unresectable SNC. Local control is encouraging with acceptable treatment-related complications when treating with the described two-phase IMRT treatment technique.
abstractGer	Objectives The aim of this study is to review radiotherapy (RT) techniques and outcomes for definitive RT or chemoradiotherapy (CRT) for very locally advanced or unresectable sinonasal cancer (SNC) at a single institution. Methods Between 1998 and 2010, there were 11 patients with very locally advanced or unresectable SNCs treated with definitive CRT (8) and RT alone (3) at the University of Utah. CRT was given to stage IVA (5) and stage IVB (3) patients; RT alone was given to stage III (1) and stage IVA (2) patients. All patients were treated with intensity-modulated radiation therapy (IMRT). The median dose was 70.2 Gy (70–72.4 Gy). Most patients underwent two treatment planning phases in order to prevent critical structures from receiving a high dose due to tumor regression and weight loss. The most common chemotherapy was cisplatin 40 mg/$ m^{2} $ given on a weekly basis for 6–7 cycles. A flexible nasal endoscopy with a biopsy was performed 3 months posttreatment to evaluate tumor response. Results With a median follow-up of 41 months (2–114), overall local control was seen in 8 out of 11 (72.7 %) patients. There was 1 (9.1 %) regional recurrence and 2 (18.2 %) distant metastasis. The definitive CRT or RT was well tolerated with only 2 patients experiencing a grade 3 late toxicity. Conclusion Definitive CRT or RT is feasible for very locally advanced or unresectable SNC. Local control is encouraging with acceptable treatment-related complications when treating with the described two-phase IMRT treatment technique.
abstract_unstemmed	Objectives The aim of this study is to review radiotherapy (RT) techniques and outcomes for definitive RT or chemoradiotherapy (CRT) for very locally advanced or unresectable sinonasal cancer (SNC) at a single institution. Methods Between 1998 and 2010, there were 11 patients with very locally advanced or unresectable SNCs treated with definitive CRT (8) and RT alone (3) at the University of Utah. CRT was given to stage IVA (5) and stage IVB (3) patients; RT alone was given to stage III (1) and stage IVA (2) patients. All patients were treated with intensity-modulated radiation therapy (IMRT). The median dose was 70.2 Gy (70–72.4 Gy). Most patients underwent two treatment planning phases in order to prevent critical structures from receiving a high dose due to tumor regression and weight loss. The most common chemotherapy was cisplatin 40 mg/$ m^{2} $ given on a weekly basis for 6–7 cycles. A flexible nasal endoscopy with a biopsy was performed 3 months posttreatment to evaluate tumor response. Results With a median follow-up of 41 months (2–114), overall local control was seen in 8 out of 11 (72.7 %) patients. There was 1 (9.1 %) regional recurrence and 2 (18.2 %) distant metastasis. The definitive CRT or RT was well tolerated with only 2 patients experiencing a grade 3 late toxicity. Conclusion Definitive CRT or RT is feasible for very locally advanced or unresectable SNC. Local control is encouraging with acceptable treatment-related complications when treating with the described two-phase IMRT treatment technique.
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title_short	Function preservation and optimal outcomes—definitive chemoradiotherapy with multi-phase treatment planning for locally advanced sinonasal cancer
url	https://dx.doi.org/10.1007/s13566-015-0226-3
remote_bool	true
author2	Orlandi, Richard R. Hunt, Jason P. Buchmann, Luke O. Grossman, Kenneth F. Monroe, Marcus M. Shrieve, Dennis C. Hitchcock, Ying J.
author2Str	Orlandi, Richard R. Hunt, Jason P. Buchmann, Luke O. Grossman, Kenneth F. Monroe, Marcus M. Shrieve, Dennis C. Hitchcock, Ying J.
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doi_str	10.1007/s13566-015-0226-3
up_date	2024-07-04T01:20:50.059Z
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Methods Between 1998 and 2010, there were 11 patients with very locally advanced or unresectable SNCs treated with definitive CRT (8) and RT alone (3) at the University of Utah. CRT was given to stage IVA (5) and stage IVB (3) patients; RT alone was given to stage III (1) and stage IVA (2) patients. All patients were treated with intensity-modulated radiation therapy (IMRT). The median dose was 70.2 Gy (70–72.4 Gy). Most patients underwent two treatment planning phases in order to prevent critical structures from receiving a high dose due to tumor regression and weight loss. The most common chemotherapy was cisplatin 40 mg/$ m^{2} $ given on a weekly basis for 6–7 cycles. A flexible nasal endoscopy with a biopsy was performed 3 months posttreatment to evaluate tumor response. Results With a median follow-up of 41 months (2–114), overall local control was seen in 8 out of 11 (72.7 %) patients. There was 1 (9.1 %) regional recurrence and 2 (18.2 %) distant metastasis. The definitive CRT or RT was well tolerated with only 2 patients experiencing a grade 3 late toxicity. Conclusion Definitive CRT or RT is feasible for very locally advanced or unresectable SNC. 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Function preservation and optimal outcomes—definitive chemoradiotherapy with multi-phase treatment planning for locally advanced sinonasal cancer

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