Recurrent glioblastoma: a single-institution experience with reirradiation and temozolomide
Background Glioblastoma is an aggressive disease with poor prognosis. Outcomes following recurrences are dismal despite the use of multimodality treatment. Surgery is usually not a viable option, and even in those who do undergo surgery, adjuvant radiation therapy with or without concurrent chemothe...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Kataria, Tejinder [verfasserIn] Gupta, Deepak [verfasserIn] Gupta, Ratika [verfasserIn] Goyal, Shikha [verfasserIn] Bisht, Shyam Singh [verfasserIn] Basu, Trinanjan [verfasserIn] Abhishek, Ashu [verfasserIn] Narang, Kushal [verfasserIn] Banerjee, Susovan [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Übergeordnetes Werk: |
Enthalten in: Journal of radiation oncology - Berlin : Springer, 2012, 6(2017), 2 vom: 22. Apr., Seite 133-141 |
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| Übergeordnetes Werk: |
volume:6 ; year:2017 ; number:2 ; day:22 ; month:04 ; pages:133-141 |
| Links: |
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| DOI / URN: |
10.1007/s13566-017-0307-6 |
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| Katalog-ID: |
SPR031812392 |
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| 245 | 1 | 0 | |a Recurrent glioblastoma: a single-institution experience with reirradiation and temozolomide |
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| 520 | |a Background Glioblastoma is an aggressive disease with poor prognosis. Outcomes following recurrences are dismal despite the use of multimodality treatment. Surgery is usually not a viable option, and even in those who do undergo surgery, adjuvant radiation therapy with or without concurrent chemotherapy may be viable options depending on several factors such as performance status, disease volume, and time since prior therapy. We intended to assess the efficacy of high precision reirradiation with temozolomide as a salvage modality in patients with recurrent glioblastoma. Methods Twenty-five patients with recurrent glioblastoma who received reirradiation (with or without concurrent temozolomide) for recurrence at our department between 2010 and 2015 were included in this retrospective analysis. Treatment decisions are taken following recommendations of multidisciplinary tumor board. Treatment details were noted from respective case records. Survival time was calculated using Kaplan-Meier method. Univariate and multivariate analyses were performed using Cox regression analysis. Results Eighteen men and seven women with a mean age of 52 years (range, 20–65 years) received reirradiation during the given period. Median Karnofsky Performance Score (KPS) was 70% (range, 40–90). Twelve patients underwent surgery before reirradiation, while 13 patients were deemed inoperable and direct taken for reirradiation. The reirradiation methods included stereotactic radiosurgery (2), hypofractionated stereotactic radiation therapy (15–40 Gy in 3–5 fractions; 14 patients), or conventionally fractionated stereotactic radiation therapy (45–54 Gy in 25–27 fractions; 9 patients). Patients who received conventional fractionated radiation also received concurrent temozolomide at 75 mg/$ m^{2} $. All patients completed the planned course of radiation therapy and also received adjuvant temozolomide. MGMT methylation status was available for 15 patients; 7 had MGMT methylated while 8 had non-methylated tumors. Median follow-up from recurrence was 12 months (range, 1–47.8 months). Median overall survival (OS) from recurrence was 15.2 months (95% confidence interval [CI], 10–20.33 months). None of the factors analyzed (age, sex, gross tumor volume at time of recurrence, KPS, MGMT, time of recurrence) were significant for outcomes. No grade 3 or above acute or late complications were noted following reirradiation. Conclusions Our results suggest that reirradiation with high precision radiotherapy along with temozolomide is an effective option in patients with recurrent glioblastoma. | ||
| 650 | 4 | |a Recurrent glioblastoma |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Reirradiation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Temozolomide |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Gupta, Deepak |e verfasserin |4 aut | |
| 700 | 1 | |a Gupta, Ratika |e verfasserin |4 aut | |
| 700 | 1 | |a Goyal, Shikha |e verfasserin |4 aut | |
| 700 | 1 | |a Bisht, Shyam Singh |e verfasserin |4 aut | |
| 700 | 1 | |a Basu, Trinanjan |e verfasserin |4 aut | |
| 700 | 1 | |a Abhishek, Ashu |e verfasserin |4 aut | |
| 700 | 1 | |a Narang, Kushal |e verfasserin |4 aut | |
| 700 | 1 | |a Banerjee, Susovan |e verfasserin |4 aut | |
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10.1007/s13566-017-0307-6 doi (DE-627)SPR031812392 (SPR)s13566-017-0307-6-e DE-627 ger DE-627 rakwb eng 610 ASE Kataria, Tejinder verfasserin aut Recurrent glioblastoma: a single-institution experience with reirradiation and temozolomide 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Glioblastoma is an aggressive disease with poor prognosis. Outcomes following recurrences are dismal despite the use of multimodality treatment. Surgery is usually not a viable option, and even in those who do undergo surgery, adjuvant radiation therapy with or without concurrent chemotherapy may be viable options depending on several factors such as performance status, disease volume, and time since prior therapy. We intended to assess the efficacy of high precision reirradiation with temozolomide as a salvage modality in patients with recurrent glioblastoma. Methods Twenty-five patients with recurrent glioblastoma who received reirradiation (with or without concurrent temozolomide) for recurrence at our department between 2010 and 2015 were included in this retrospective analysis. Treatment decisions are taken following recommendations of multidisciplinary tumor board. Treatment details were noted from respective case records. Survival time was calculated using Kaplan-Meier method. Univariate and multivariate analyses were performed using Cox regression analysis. Results Eighteen men and seven women with a mean age of 52 years (range, 20–65 years) received reirradiation during the given period. Median Karnofsky Performance Score (KPS) was 70% (range, 40–90). Twelve patients underwent surgery before reirradiation, while 13 patients were deemed inoperable and direct taken for reirradiation. The reirradiation methods included stereotactic radiosurgery (2), hypofractionated stereotactic radiation therapy (15–40 Gy in 3–5 fractions; 14 patients), or conventionally fractionated stereotactic radiation therapy (45–54 Gy in 25–27 fractions; 9 patients). Patients who received conventional fractionated radiation also received concurrent temozolomide at 75 mg/$ m^{2} $. All patients completed the planned course of radiation therapy and also received adjuvant temozolomide. MGMT methylation status was available for 15 patients; 7 had MGMT methylated while 8 had non-methylated tumors. Median follow-up from recurrence was 12 months (range, 1–47.8 months). Median overall survival (OS) from recurrence was 15.2 months (95% confidence interval [CI], 10–20.33 months). None of the factors analyzed (age, sex, gross tumor volume at time of recurrence, KPS, MGMT, time of recurrence) were significant for outcomes. No grade 3 or above acute or late complications were noted following reirradiation. Conclusions Our results suggest that reirradiation with high precision radiotherapy along with temozolomide is an effective option in patients with recurrent glioblastoma. Recurrent glioblastoma (dpeaa)DE-He213 Reirradiation (dpeaa)DE-He213 Temozolomide (dpeaa)DE-He213 Gupta, Deepak verfasserin aut Gupta, Ratika verfasserin aut Goyal, Shikha verfasserin aut Bisht, Shyam Singh verfasserin aut Basu, Trinanjan verfasserin aut Abhishek, Ashu verfasserin aut Narang, Kushal verfasserin aut Banerjee, Susovan verfasserin aut Enthalten in Journal of radiation oncology Berlin : Springer, 2012 6(2017), 2 vom: 22. Apr., Seite 133-141 (DE-627)718611233 (DE-600)2660511-9 1948-7908 nnns volume:6 year:2017 number:2 day:22 month:04 pages:133-141 https://dx.doi.org/10.1007/s13566-017-0307-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 6 2017 2 22 04 133-141 |
| spelling |
10.1007/s13566-017-0307-6 doi (DE-627)SPR031812392 (SPR)s13566-017-0307-6-e DE-627 ger DE-627 rakwb eng 610 ASE Kataria, Tejinder verfasserin aut Recurrent glioblastoma: a single-institution experience with reirradiation and temozolomide 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Glioblastoma is an aggressive disease with poor prognosis. Outcomes following recurrences are dismal despite the use of multimodality treatment. Surgery is usually not a viable option, and even in those who do undergo surgery, adjuvant radiation therapy with or without concurrent chemotherapy may be viable options depending on several factors such as performance status, disease volume, and time since prior therapy. We intended to assess the efficacy of high precision reirradiation with temozolomide as a salvage modality in patients with recurrent glioblastoma. Methods Twenty-five patients with recurrent glioblastoma who received reirradiation (with or without concurrent temozolomide) for recurrence at our department between 2010 and 2015 were included in this retrospective analysis. Treatment decisions are taken following recommendations of multidisciplinary tumor board. Treatment details were noted from respective case records. Survival time was calculated using Kaplan-Meier method. Univariate and multivariate analyses were performed using Cox regression analysis. Results Eighteen men and seven women with a mean age of 52 years (range, 20–65 years) received reirradiation during the given period. Median Karnofsky Performance Score (KPS) was 70% (range, 40–90). Twelve patients underwent surgery before reirradiation, while 13 patients were deemed inoperable and direct taken for reirradiation. The reirradiation methods included stereotactic radiosurgery (2), hypofractionated stereotactic radiation therapy (15–40 Gy in 3–5 fractions; 14 patients), or conventionally fractionated stereotactic radiation therapy (45–54 Gy in 25–27 fractions; 9 patients). Patients who received conventional fractionated radiation also received concurrent temozolomide at 75 mg/$ m^{2} $. All patients completed the planned course of radiation therapy and also received adjuvant temozolomide. MGMT methylation status was available for 15 patients; 7 had MGMT methylated while 8 had non-methylated tumors. Median follow-up from recurrence was 12 months (range, 1–47.8 months). Median overall survival (OS) from recurrence was 15.2 months (95% confidence interval [CI], 10–20.33 months). None of the factors analyzed (age, sex, gross tumor volume at time of recurrence, KPS, MGMT, time of recurrence) were significant for outcomes. No grade 3 or above acute or late complications were noted following reirradiation. Conclusions Our results suggest that reirradiation with high precision radiotherapy along with temozolomide is an effective option in patients with recurrent glioblastoma. Recurrent glioblastoma (dpeaa)DE-He213 Reirradiation (dpeaa)DE-He213 Temozolomide (dpeaa)DE-He213 Gupta, Deepak verfasserin aut Gupta, Ratika verfasserin aut Goyal, Shikha verfasserin aut Bisht, Shyam Singh verfasserin aut Basu, Trinanjan verfasserin aut Abhishek, Ashu verfasserin aut Narang, Kushal verfasserin aut Banerjee, Susovan verfasserin aut Enthalten in Journal of radiation oncology Berlin : Springer, 2012 6(2017), 2 vom: 22. Apr., Seite 133-141 (DE-627)718611233 (DE-600)2660511-9 1948-7908 nnns volume:6 year:2017 number:2 day:22 month:04 pages:133-141 https://dx.doi.org/10.1007/s13566-017-0307-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 6 2017 2 22 04 133-141 |
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10.1007/s13566-017-0307-6 doi (DE-627)SPR031812392 (SPR)s13566-017-0307-6-e DE-627 ger DE-627 rakwb eng 610 ASE Kataria, Tejinder verfasserin aut Recurrent glioblastoma: a single-institution experience with reirradiation and temozolomide 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Glioblastoma is an aggressive disease with poor prognosis. Outcomes following recurrences are dismal despite the use of multimodality treatment. Surgery is usually not a viable option, and even in those who do undergo surgery, adjuvant radiation therapy with or without concurrent chemotherapy may be viable options depending on several factors such as performance status, disease volume, and time since prior therapy. We intended to assess the efficacy of high precision reirradiation with temozolomide as a salvage modality in patients with recurrent glioblastoma. Methods Twenty-five patients with recurrent glioblastoma who received reirradiation (with or without concurrent temozolomide) for recurrence at our department between 2010 and 2015 were included in this retrospective analysis. Treatment decisions are taken following recommendations of multidisciplinary tumor board. Treatment details were noted from respective case records. Survival time was calculated using Kaplan-Meier method. Univariate and multivariate analyses were performed using Cox regression analysis. Results Eighteen men and seven women with a mean age of 52 years (range, 20–65 years) received reirradiation during the given period. Median Karnofsky Performance Score (KPS) was 70% (range, 40–90). Twelve patients underwent surgery before reirradiation, while 13 patients were deemed inoperable and direct taken for reirradiation. The reirradiation methods included stereotactic radiosurgery (2), hypofractionated stereotactic radiation therapy (15–40 Gy in 3–5 fractions; 14 patients), or conventionally fractionated stereotactic radiation therapy (45–54 Gy in 25–27 fractions; 9 patients). Patients who received conventional fractionated radiation also received concurrent temozolomide at 75 mg/$ m^{2} $. All patients completed the planned course of radiation therapy and also received adjuvant temozolomide. MGMT methylation status was available for 15 patients; 7 had MGMT methylated while 8 had non-methylated tumors. Median follow-up from recurrence was 12 months (range, 1–47.8 months). Median overall survival (OS) from recurrence was 15.2 months (95% confidence interval [CI], 10–20.33 months). None of the factors analyzed (age, sex, gross tumor volume at time of recurrence, KPS, MGMT, time of recurrence) were significant for outcomes. No grade 3 or above acute or late complications were noted following reirradiation. Conclusions Our results suggest that reirradiation with high precision radiotherapy along with temozolomide is an effective option in patients with recurrent glioblastoma. Recurrent glioblastoma (dpeaa)DE-He213 Reirradiation (dpeaa)DE-He213 Temozolomide (dpeaa)DE-He213 Gupta, Deepak verfasserin aut Gupta, Ratika verfasserin aut Goyal, Shikha verfasserin aut Bisht, Shyam Singh verfasserin aut Basu, Trinanjan verfasserin aut Abhishek, Ashu verfasserin aut Narang, Kushal verfasserin aut Banerjee, Susovan verfasserin aut Enthalten in Journal of radiation oncology Berlin : Springer, 2012 6(2017), 2 vom: 22. Apr., Seite 133-141 (DE-627)718611233 (DE-600)2660511-9 1948-7908 nnns volume:6 year:2017 number:2 day:22 month:04 pages:133-141 https://dx.doi.org/10.1007/s13566-017-0307-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 6 2017 2 22 04 133-141 |
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10.1007/s13566-017-0307-6 doi (DE-627)SPR031812392 (SPR)s13566-017-0307-6-e DE-627 ger DE-627 rakwb eng 610 ASE Kataria, Tejinder verfasserin aut Recurrent glioblastoma: a single-institution experience with reirradiation and temozolomide 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Glioblastoma is an aggressive disease with poor prognosis. Outcomes following recurrences are dismal despite the use of multimodality treatment. Surgery is usually not a viable option, and even in those who do undergo surgery, adjuvant radiation therapy with or without concurrent chemotherapy may be viable options depending on several factors such as performance status, disease volume, and time since prior therapy. We intended to assess the efficacy of high precision reirradiation with temozolomide as a salvage modality in patients with recurrent glioblastoma. Methods Twenty-five patients with recurrent glioblastoma who received reirradiation (with or without concurrent temozolomide) for recurrence at our department between 2010 and 2015 were included in this retrospective analysis. Treatment decisions are taken following recommendations of multidisciplinary tumor board. Treatment details were noted from respective case records. Survival time was calculated using Kaplan-Meier method. Univariate and multivariate analyses were performed using Cox regression analysis. Results Eighteen men and seven women with a mean age of 52 years (range, 20–65 years) received reirradiation during the given period. Median Karnofsky Performance Score (KPS) was 70% (range, 40–90). Twelve patients underwent surgery before reirradiation, while 13 patients were deemed inoperable and direct taken for reirradiation. The reirradiation methods included stereotactic radiosurgery (2), hypofractionated stereotactic radiation therapy (15–40 Gy in 3–5 fractions; 14 patients), or conventionally fractionated stereotactic radiation therapy (45–54 Gy in 25–27 fractions; 9 patients). Patients who received conventional fractionated radiation also received concurrent temozolomide at 75 mg/$ m^{2} $. All patients completed the planned course of radiation therapy and also received adjuvant temozolomide. MGMT methylation status was available for 15 patients; 7 had MGMT methylated while 8 had non-methylated tumors. Median follow-up from recurrence was 12 months (range, 1–47.8 months). Median overall survival (OS) from recurrence was 15.2 months (95% confidence interval [CI], 10–20.33 months). None of the factors analyzed (age, sex, gross tumor volume at time of recurrence, KPS, MGMT, time of recurrence) were significant for outcomes. No grade 3 or above acute or late complications were noted following reirradiation. Conclusions Our results suggest that reirradiation with high precision radiotherapy along with temozolomide is an effective option in patients with recurrent glioblastoma. Recurrent glioblastoma (dpeaa)DE-He213 Reirradiation (dpeaa)DE-He213 Temozolomide (dpeaa)DE-He213 Gupta, Deepak verfasserin aut Gupta, Ratika verfasserin aut Goyal, Shikha verfasserin aut Bisht, Shyam Singh verfasserin aut Basu, Trinanjan verfasserin aut Abhishek, Ashu verfasserin aut Narang, Kushal verfasserin aut Banerjee, Susovan verfasserin aut Enthalten in Journal of radiation oncology Berlin : Springer, 2012 6(2017), 2 vom: 22. Apr., Seite 133-141 (DE-627)718611233 (DE-600)2660511-9 1948-7908 nnns volume:6 year:2017 number:2 day:22 month:04 pages:133-141 https://dx.doi.org/10.1007/s13566-017-0307-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 6 2017 2 22 04 133-141 |
| allfieldsSound |
10.1007/s13566-017-0307-6 doi (DE-627)SPR031812392 (SPR)s13566-017-0307-6-e DE-627 ger DE-627 rakwb eng 610 ASE Kataria, Tejinder verfasserin aut Recurrent glioblastoma: a single-institution experience with reirradiation and temozolomide 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Glioblastoma is an aggressive disease with poor prognosis. Outcomes following recurrences are dismal despite the use of multimodality treatment. Surgery is usually not a viable option, and even in those who do undergo surgery, adjuvant radiation therapy with or without concurrent chemotherapy may be viable options depending on several factors such as performance status, disease volume, and time since prior therapy. We intended to assess the efficacy of high precision reirradiation with temozolomide as a salvage modality in patients with recurrent glioblastoma. Methods Twenty-five patients with recurrent glioblastoma who received reirradiation (with or without concurrent temozolomide) for recurrence at our department between 2010 and 2015 were included in this retrospective analysis. Treatment decisions are taken following recommendations of multidisciplinary tumor board. Treatment details were noted from respective case records. Survival time was calculated using Kaplan-Meier method. Univariate and multivariate analyses were performed using Cox regression analysis. Results Eighteen men and seven women with a mean age of 52 years (range, 20–65 years) received reirradiation during the given period. Median Karnofsky Performance Score (KPS) was 70% (range, 40–90). Twelve patients underwent surgery before reirradiation, while 13 patients were deemed inoperable and direct taken for reirradiation. The reirradiation methods included stereotactic radiosurgery (2), hypofractionated stereotactic radiation therapy (15–40 Gy in 3–5 fractions; 14 patients), or conventionally fractionated stereotactic radiation therapy (45–54 Gy in 25–27 fractions; 9 patients). Patients who received conventional fractionated radiation also received concurrent temozolomide at 75 mg/$ m^{2} $. All patients completed the planned course of radiation therapy and also received adjuvant temozolomide. MGMT methylation status was available for 15 patients; 7 had MGMT methylated while 8 had non-methylated tumors. Median follow-up from recurrence was 12 months (range, 1–47.8 months). Median overall survival (OS) from recurrence was 15.2 months (95% confidence interval [CI], 10–20.33 months). None of the factors analyzed (age, sex, gross tumor volume at time of recurrence, KPS, MGMT, time of recurrence) were significant for outcomes. No grade 3 or above acute or late complications were noted following reirradiation. Conclusions Our results suggest that reirradiation with high precision radiotherapy along with temozolomide is an effective option in patients with recurrent glioblastoma. Recurrent glioblastoma (dpeaa)DE-He213 Reirradiation (dpeaa)DE-He213 Temozolomide (dpeaa)DE-He213 Gupta, Deepak verfasserin aut Gupta, Ratika verfasserin aut Goyal, Shikha verfasserin aut Bisht, Shyam Singh verfasserin aut Basu, Trinanjan verfasserin aut Abhishek, Ashu verfasserin aut Narang, Kushal verfasserin aut Banerjee, Susovan verfasserin aut Enthalten in Journal of radiation oncology Berlin : Springer, 2012 6(2017), 2 vom: 22. Apr., Seite 133-141 (DE-627)718611233 (DE-600)2660511-9 1948-7908 nnns volume:6 year:2017 number:2 day:22 month:04 pages:133-141 https://dx.doi.org/10.1007/s13566-017-0307-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 6 2017 2 22 04 133-141 |
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Enthalten in Journal of radiation oncology 6(2017), 2 vom: 22. Apr., Seite 133-141 volume:6 year:2017 number:2 day:22 month:04 pages:133-141 |
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Enthalten in Journal of radiation oncology 6(2017), 2 vom: 22. Apr., Seite 133-141 volume:6 year:2017 number:2 day:22 month:04 pages:133-141 |
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Recurrent glioblastoma Reirradiation Temozolomide |
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Kataria, Tejinder @@aut@@ Gupta, Deepak @@aut@@ Gupta, Ratika @@aut@@ Goyal, Shikha @@aut@@ Bisht, Shyam Singh @@aut@@ Basu, Trinanjan @@aut@@ Abhishek, Ashu @@aut@@ Narang, Kushal @@aut@@ Banerjee, Susovan @@aut@@ |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR031812392</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519141841.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201007s2017 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s13566-017-0307-6</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR031812392</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s13566-017-0307-6-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Kataria, Tejinder</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Recurrent glioblastoma: a single-institution experience with reirradiation and temozolomide</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2017</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Glioblastoma is an aggressive disease with poor prognosis. Outcomes following recurrences are dismal despite the use of multimodality treatment. Surgery is usually not a viable option, and even in those who do undergo surgery, adjuvant radiation therapy with or without concurrent chemotherapy may be viable options depending on several factors such as performance status, disease volume, and time since prior therapy. We intended to assess the efficacy of high precision reirradiation with temozolomide as a salvage modality in patients with recurrent glioblastoma. Methods Twenty-five patients with recurrent glioblastoma who received reirradiation (with or without concurrent temozolomide) for recurrence at our department between 2010 and 2015 were included in this retrospective analysis. Treatment decisions are taken following recommendations of multidisciplinary tumor board. Treatment details were noted from respective case records. Survival time was calculated using Kaplan-Meier method. Univariate and multivariate analyses were performed using Cox regression analysis. Results Eighteen men and seven women with a mean age of 52 years (range, 20–65 years) received reirradiation during the given period. Median Karnofsky Performance Score (KPS) was 70% (range, 40–90). Twelve patients underwent surgery before reirradiation, while 13 patients were deemed inoperable and direct taken for reirradiation. The reirradiation methods included stereotactic radiosurgery (2), hypofractionated stereotactic radiation therapy (15–40 Gy in 3–5 fractions; 14 patients), or conventionally fractionated stereotactic radiation therapy (45–54 Gy in 25–27 fractions; 9 patients). Patients who received conventional fractionated radiation also received concurrent temozolomide at 75 mg/$ m^{2} $. All patients completed the planned course of radiation therapy and also received adjuvant temozolomide. MGMT methylation status was available for 15 patients; 7 had MGMT methylated while 8 had non-methylated tumors. Median follow-up from recurrence was 12 months (range, 1–47.8 months). Median overall survival (OS) from recurrence was 15.2 months (95% confidence interval [CI], 10–20.33 months). None of the factors analyzed (age, sex, gross tumor volume at time of recurrence, KPS, MGMT, time of recurrence) were significant for outcomes. No grade 3 or above acute or late complications were noted following reirradiation. 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Kataria, Tejinder |
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recurrent glioblastoma: a single-institution experience with reirradiation and temozolomide |
| title_auth |
Recurrent glioblastoma: a single-institution experience with reirradiation and temozolomide |
| abstract |
Background Glioblastoma is an aggressive disease with poor prognosis. Outcomes following recurrences are dismal despite the use of multimodality treatment. Surgery is usually not a viable option, and even in those who do undergo surgery, adjuvant radiation therapy with or without concurrent chemotherapy may be viable options depending on several factors such as performance status, disease volume, and time since prior therapy. We intended to assess the efficacy of high precision reirradiation with temozolomide as a salvage modality in patients with recurrent glioblastoma. Methods Twenty-five patients with recurrent glioblastoma who received reirradiation (with or without concurrent temozolomide) for recurrence at our department between 2010 and 2015 were included in this retrospective analysis. Treatment decisions are taken following recommendations of multidisciplinary tumor board. Treatment details were noted from respective case records. Survival time was calculated using Kaplan-Meier method. Univariate and multivariate analyses were performed using Cox regression analysis. Results Eighteen men and seven women with a mean age of 52 years (range, 20–65 years) received reirradiation during the given period. Median Karnofsky Performance Score (KPS) was 70% (range, 40–90). Twelve patients underwent surgery before reirradiation, while 13 patients were deemed inoperable and direct taken for reirradiation. The reirradiation methods included stereotactic radiosurgery (2), hypofractionated stereotactic radiation therapy (15–40 Gy in 3–5 fractions; 14 patients), or conventionally fractionated stereotactic radiation therapy (45–54 Gy in 25–27 fractions; 9 patients). Patients who received conventional fractionated radiation also received concurrent temozolomide at 75 mg/$ m^{2} $. All patients completed the planned course of radiation therapy and also received adjuvant temozolomide. MGMT methylation status was available for 15 patients; 7 had MGMT methylated while 8 had non-methylated tumors. Median follow-up from recurrence was 12 months (range, 1–47.8 months). Median overall survival (OS) from recurrence was 15.2 months (95% confidence interval [CI], 10–20.33 months). None of the factors analyzed (age, sex, gross tumor volume at time of recurrence, KPS, MGMT, time of recurrence) were significant for outcomes. No grade 3 or above acute or late complications were noted following reirradiation. Conclusions Our results suggest that reirradiation with high precision radiotherapy along with temozolomide is an effective option in patients with recurrent glioblastoma. |
| abstractGer |
Background Glioblastoma is an aggressive disease with poor prognosis. Outcomes following recurrences are dismal despite the use of multimodality treatment. Surgery is usually not a viable option, and even in those who do undergo surgery, adjuvant radiation therapy with or without concurrent chemotherapy may be viable options depending on several factors such as performance status, disease volume, and time since prior therapy. We intended to assess the efficacy of high precision reirradiation with temozolomide as a salvage modality in patients with recurrent glioblastoma. Methods Twenty-five patients with recurrent glioblastoma who received reirradiation (with or without concurrent temozolomide) for recurrence at our department between 2010 and 2015 were included in this retrospective analysis. Treatment decisions are taken following recommendations of multidisciplinary tumor board. Treatment details were noted from respective case records. Survival time was calculated using Kaplan-Meier method. Univariate and multivariate analyses were performed using Cox regression analysis. Results Eighteen men and seven women with a mean age of 52 years (range, 20–65 years) received reirradiation during the given period. Median Karnofsky Performance Score (KPS) was 70% (range, 40–90). Twelve patients underwent surgery before reirradiation, while 13 patients were deemed inoperable and direct taken for reirradiation. The reirradiation methods included stereotactic radiosurgery (2), hypofractionated stereotactic radiation therapy (15–40 Gy in 3–5 fractions; 14 patients), or conventionally fractionated stereotactic radiation therapy (45–54 Gy in 25–27 fractions; 9 patients). Patients who received conventional fractionated radiation also received concurrent temozolomide at 75 mg/$ m^{2} $. All patients completed the planned course of radiation therapy and also received adjuvant temozolomide. MGMT methylation status was available for 15 patients; 7 had MGMT methylated while 8 had non-methylated tumors. Median follow-up from recurrence was 12 months (range, 1–47.8 months). Median overall survival (OS) from recurrence was 15.2 months (95% confidence interval [CI], 10–20.33 months). None of the factors analyzed (age, sex, gross tumor volume at time of recurrence, KPS, MGMT, time of recurrence) were significant for outcomes. No grade 3 or above acute or late complications were noted following reirradiation. Conclusions Our results suggest that reirradiation with high precision radiotherapy along with temozolomide is an effective option in patients with recurrent glioblastoma. |
| abstract_unstemmed |
Background Glioblastoma is an aggressive disease with poor prognosis. Outcomes following recurrences are dismal despite the use of multimodality treatment. Surgery is usually not a viable option, and even in those who do undergo surgery, adjuvant radiation therapy with or without concurrent chemotherapy may be viable options depending on several factors such as performance status, disease volume, and time since prior therapy. We intended to assess the efficacy of high precision reirradiation with temozolomide as a salvage modality in patients with recurrent glioblastoma. Methods Twenty-five patients with recurrent glioblastoma who received reirradiation (with or without concurrent temozolomide) for recurrence at our department between 2010 and 2015 were included in this retrospective analysis. Treatment decisions are taken following recommendations of multidisciplinary tumor board. Treatment details were noted from respective case records. Survival time was calculated using Kaplan-Meier method. Univariate and multivariate analyses were performed using Cox regression analysis. Results Eighteen men and seven women with a mean age of 52 years (range, 20–65 years) received reirradiation during the given period. Median Karnofsky Performance Score (KPS) was 70% (range, 40–90). Twelve patients underwent surgery before reirradiation, while 13 patients were deemed inoperable and direct taken for reirradiation. The reirradiation methods included stereotactic radiosurgery (2), hypofractionated stereotactic radiation therapy (15–40 Gy in 3–5 fractions; 14 patients), or conventionally fractionated stereotactic radiation therapy (45–54 Gy in 25–27 fractions; 9 patients). Patients who received conventional fractionated radiation also received concurrent temozolomide at 75 mg/$ m^{2} $. All patients completed the planned course of radiation therapy and also received adjuvant temozolomide. MGMT methylation status was available for 15 patients; 7 had MGMT methylated while 8 had non-methylated tumors. Median follow-up from recurrence was 12 months (range, 1–47.8 months). Median overall survival (OS) from recurrence was 15.2 months (95% confidence interval [CI], 10–20.33 months). None of the factors analyzed (age, sex, gross tumor volume at time of recurrence, KPS, MGMT, time of recurrence) were significant for outcomes. No grade 3 or above acute or late complications were noted following reirradiation. Conclusions Our results suggest that reirradiation with high precision radiotherapy along with temozolomide is an effective option in patients with recurrent glioblastoma. |
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Recurrent glioblastoma: a single-institution experience with reirradiation and temozolomide |
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Gupta, Deepak Gupta, Ratika Goyal, Shikha Bisht, Shyam Singh Basu, Trinanjan Abhishek, Ashu Narang, Kushal Banerjee, Susovan |
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Gupta, Deepak Gupta, Ratika Goyal, Shikha Bisht, Shyam Singh Basu, Trinanjan Abhishek, Ashu Narang, Kushal Banerjee, Susovan |
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10.1007/s13566-017-0307-6 |
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| score |
7.397456 |