Association of Trypanosoma vivax in extracellular sites with central nervous system lesions and changes in cerebrospinal fluid in experimentally infected goats

Abstract Changes in cerebrospinal fluid (CSF) and anatomical and histopathological central nervous system (CNS) lesions were evaluated, and the presence of Trypanosoma vivax in CNS tissues was investigated through PCR. Twelve adult male goats were divided into three groups (G): G1, infected with T....
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Batista, Jael S [verfasserIn] Rodrigues, Carla MF [verfasserIn] García, Herakles A [verfasserIn] Bezerra, Francisco SB [verfasserIn] Olinda, Robério G [verfasserIn] Teixeira, Marta MG [verfasserIn] Soto-Blanco, Benito [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2011

Schlagwörter:	Meningoencephalitis Bruxism Central Nervous System Tissue Central Nervous System Lesion Cerebellar White Matter

Übergeordnetes Werk:	Enthalten in: Veterinary research - London : BioMed Central, 1993, 42(2011), 1 vom: 11. Mai
Übergeordnetes Werk:	volume:42 ; year:2011 ; number:1 ; day:11 ; month:05

Links:	Volltext

DOI / URN:	10.1186/1297-9716-42-63

Katalog-ID:	SPR031814506

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allfields	10.1186/1297-9716-42-63 doi (DE-627)SPR031814506 (SPR)1297-9716-42-63-e DE-627 ger DE-627 rakwb eng 630 640 ASE 46.00 bkl Batista, Jael S verfasserin aut Association of Trypanosoma vivax in extracellular sites with central nervous system lesions and changes in cerebrospinal fluid in experimentally infected goats 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Changes in cerebrospinal fluid (CSF) and anatomical and histopathological central nervous system (CNS) lesions were evaluated, and the presence of Trypanosoma vivax in CNS tissues was investigated through PCR. Twelve adult male goats were divided into three groups (G): G1, infected with T. vivax and evaluated during the acute phase; G2, infected goats evaluated during the chronic phase; and G3, consisting of non-infected goats. Each goat from G1 and G2 was infected with 1.25 × $ 10^{5} $ trypomastigotes. Cerebrospinal fluid (CSF) analysis and investigation of T. vivax was performed at the $ 15^{th} $ day post-infection (dpi) in G1 goats and on the fifth day after the manifestation of nervous system infection signs in G2 goats. All goats were necropsied, and CNS fragments from G1 and G2 goats were evaluated by PCR for the determination of T. vivax. Hyperthermia, anemia and parasitemia were observed from the fifth dpi for G1 and G2, with the highest parasitemia peak between the seventh and $ 21^{st} $ dpi. Nervous system infection signs were observed in three G2 goats between the $ 30^{th} $ and $ 35^{th} $ dpi. CSF analysis revealed the presence of T. vivax for G2. Meningitis and meningoencephalitis were diagnosed in G2. PCR were positive for T. vivax in all the samples tested. In conclusion, T. vivax may reach the nervous tissue resulting in immune response from the host, which is the cause of progressive clinical and pathological manifestations of the CNS in experimentally infected goats. Meningoencephalitis (dpeaa)DE-He213 Bruxism (dpeaa)DE-He213 Central Nervous System Tissue (dpeaa)DE-He213 Central Nervous System Lesion (dpeaa)DE-He213 Cerebellar White Matter (dpeaa)DE-He213 Rodrigues, Carla MF verfasserin aut García, Herakles A verfasserin aut Bezerra, Francisco SB verfasserin aut Olinda, Robério G verfasserin aut Teixeira, Marta MG verfasserin aut Soto-Blanco, Benito verfasserin aut Enthalten in Veterinary research London : BioMed Central, 1993 42(2011), 1 vom: 11. Mai (DE-627)312853653 (DE-600)2012391-7 1297-9716 nnns volume:42 year:2011 number:1 day:11 month:05 https://dx.doi.org/10.1186/1297-9716-42-63 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 46.00 ASE AR 42 2011 1 11 05
spelling	10.1186/1297-9716-42-63 doi (DE-627)SPR031814506 (SPR)1297-9716-42-63-e DE-627 ger DE-627 rakwb eng 630 640 ASE 46.00 bkl Batista, Jael S verfasserin aut Association of Trypanosoma vivax in extracellular sites with central nervous system lesions and changes in cerebrospinal fluid in experimentally infected goats 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Changes in cerebrospinal fluid (CSF) and anatomical and histopathological central nervous system (CNS) lesions were evaluated, and the presence of Trypanosoma vivax in CNS tissues was investigated through PCR. Twelve adult male goats were divided into three groups (G): G1, infected with T. vivax and evaluated during the acute phase; G2, infected goats evaluated during the chronic phase; and G3, consisting of non-infected goats. Each goat from G1 and G2 was infected with 1.25 × $ 10^{5} $ trypomastigotes. Cerebrospinal fluid (CSF) analysis and investigation of T. vivax was performed at the $ 15^{th} $ day post-infection (dpi) in G1 goats and on the fifth day after the manifestation of nervous system infection signs in G2 goats. All goats were necropsied, and CNS fragments from G1 and G2 goats were evaluated by PCR for the determination of T. vivax. Hyperthermia, anemia and parasitemia were observed from the fifth dpi for G1 and G2, with the highest parasitemia peak between the seventh and $ 21^{st} $ dpi. Nervous system infection signs were observed in three G2 goats between the $ 30^{th} $ and $ 35^{th} $ dpi. CSF analysis revealed the presence of T. vivax for G2. Meningitis and meningoencephalitis were diagnosed in G2. PCR were positive for T. vivax in all the samples tested. In conclusion, T. vivax may reach the nervous tissue resulting in immune response from the host, which is the cause of progressive clinical and pathological manifestations of the CNS in experimentally infected goats. Meningoencephalitis (dpeaa)DE-He213 Bruxism (dpeaa)DE-He213 Central Nervous System Tissue (dpeaa)DE-He213 Central Nervous System Lesion (dpeaa)DE-He213 Cerebellar White Matter (dpeaa)DE-He213 Rodrigues, Carla MF verfasserin aut García, Herakles A verfasserin aut Bezerra, Francisco SB verfasserin aut Olinda, Robério G verfasserin aut Teixeira, Marta MG verfasserin aut Soto-Blanco, Benito verfasserin aut Enthalten in Veterinary research London : BioMed Central, 1993 42(2011), 1 vom: 11. Mai (DE-627)312853653 (DE-600)2012391-7 1297-9716 nnns volume:42 year:2011 number:1 day:11 month:05 https://dx.doi.org/10.1186/1297-9716-42-63 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 46.00 ASE AR 42 2011 1 11 05
allfields_unstemmed	10.1186/1297-9716-42-63 doi (DE-627)SPR031814506 (SPR)1297-9716-42-63-e DE-627 ger DE-627 rakwb eng 630 640 ASE 46.00 bkl Batista, Jael S verfasserin aut Association of Trypanosoma vivax in extracellular sites with central nervous system lesions and changes in cerebrospinal fluid in experimentally infected goats 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Changes in cerebrospinal fluid (CSF) and anatomical and histopathological central nervous system (CNS) lesions were evaluated, and the presence of Trypanosoma vivax in CNS tissues was investigated through PCR. Twelve adult male goats were divided into three groups (G): G1, infected with T. vivax and evaluated during the acute phase; G2, infected goats evaluated during the chronic phase; and G3, consisting of non-infected goats. Each goat from G1 and G2 was infected with 1.25 × $ 10^{5} $ trypomastigotes. Cerebrospinal fluid (CSF) analysis and investigation of T. vivax was performed at the $ 15^{th} $ day post-infection (dpi) in G1 goats and on the fifth day after the manifestation of nervous system infection signs in G2 goats. All goats were necropsied, and CNS fragments from G1 and G2 goats were evaluated by PCR for the determination of T. vivax. Hyperthermia, anemia and parasitemia were observed from the fifth dpi for G1 and G2, with the highest parasitemia peak between the seventh and $ 21^{st} $ dpi. Nervous system infection signs were observed in three G2 goats between the $ 30^{th} $ and $ 35^{th} $ dpi. CSF analysis revealed the presence of T. vivax for G2. Meningitis and meningoencephalitis were diagnosed in G2. PCR were positive for T. vivax in all the samples tested. In conclusion, T. vivax may reach the nervous tissue resulting in immune response from the host, which is the cause of progressive clinical and pathological manifestations of the CNS in experimentally infected goats. Meningoencephalitis (dpeaa)DE-He213 Bruxism (dpeaa)DE-He213 Central Nervous System Tissue (dpeaa)DE-He213 Central Nervous System Lesion (dpeaa)DE-He213 Cerebellar White Matter (dpeaa)DE-He213 Rodrigues, Carla MF verfasserin aut García, Herakles A verfasserin aut Bezerra, Francisco SB verfasserin aut Olinda, Robério G verfasserin aut Teixeira, Marta MG verfasserin aut Soto-Blanco, Benito verfasserin aut Enthalten in Veterinary research London : BioMed Central, 1993 42(2011), 1 vom: 11. Mai (DE-627)312853653 (DE-600)2012391-7 1297-9716 nnns volume:42 year:2011 number:1 day:11 month:05 https://dx.doi.org/10.1186/1297-9716-42-63 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 46.00 ASE AR 42 2011 1 11 05
allfieldsGer	10.1186/1297-9716-42-63 doi (DE-627)SPR031814506 (SPR)1297-9716-42-63-e DE-627 ger DE-627 rakwb eng 630 640 ASE 46.00 bkl Batista, Jael S verfasserin aut Association of Trypanosoma vivax in extracellular sites with central nervous system lesions and changes in cerebrospinal fluid in experimentally infected goats 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Changes in cerebrospinal fluid (CSF) and anatomical and histopathological central nervous system (CNS) lesions were evaluated, and the presence of Trypanosoma vivax in CNS tissues was investigated through PCR. Twelve adult male goats were divided into three groups (G): G1, infected with T. vivax and evaluated during the acute phase; G2, infected goats evaluated during the chronic phase; and G3, consisting of non-infected goats. Each goat from G1 and G2 was infected with 1.25 × $ 10^{5} $ trypomastigotes. Cerebrospinal fluid (CSF) analysis and investigation of T. vivax was performed at the $ 15^{th} $ day post-infection (dpi) in G1 goats and on the fifth day after the manifestation of nervous system infection signs in G2 goats. All goats were necropsied, and CNS fragments from G1 and G2 goats were evaluated by PCR for the determination of T. vivax. Hyperthermia, anemia and parasitemia were observed from the fifth dpi for G1 and G2, with the highest parasitemia peak between the seventh and $ 21^{st} $ dpi. Nervous system infection signs were observed in three G2 goats between the $ 30^{th} $ and $ 35^{th} $ dpi. CSF analysis revealed the presence of T. vivax for G2. Meningitis and meningoencephalitis were diagnosed in G2. PCR were positive for T. vivax in all the samples tested. In conclusion, T. vivax may reach the nervous tissue resulting in immune response from the host, which is the cause of progressive clinical and pathological manifestations of the CNS in experimentally infected goats. Meningoencephalitis (dpeaa)DE-He213 Bruxism (dpeaa)DE-He213 Central Nervous System Tissue (dpeaa)DE-He213 Central Nervous System Lesion (dpeaa)DE-He213 Cerebellar White Matter (dpeaa)DE-He213 Rodrigues, Carla MF verfasserin aut García, Herakles A verfasserin aut Bezerra, Francisco SB verfasserin aut Olinda, Robério G verfasserin aut Teixeira, Marta MG verfasserin aut Soto-Blanco, Benito verfasserin aut Enthalten in Veterinary research London : BioMed Central, 1993 42(2011), 1 vom: 11. Mai (DE-627)312853653 (DE-600)2012391-7 1297-9716 nnns volume:42 year:2011 number:1 day:11 month:05 https://dx.doi.org/10.1186/1297-9716-42-63 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 46.00 ASE AR 42 2011 1 11 05
allfieldsSound	10.1186/1297-9716-42-63 doi (DE-627)SPR031814506 (SPR)1297-9716-42-63-e DE-627 ger DE-627 rakwb eng 630 640 ASE 46.00 bkl Batista, Jael S verfasserin aut Association of Trypanosoma vivax in extracellular sites with central nervous system lesions and changes in cerebrospinal fluid in experimentally infected goats 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Changes in cerebrospinal fluid (CSF) and anatomical and histopathological central nervous system (CNS) lesions were evaluated, and the presence of Trypanosoma vivax in CNS tissues was investigated through PCR. Twelve adult male goats were divided into three groups (G): G1, infected with T. vivax and evaluated during the acute phase; G2, infected goats evaluated during the chronic phase; and G3, consisting of non-infected goats. Each goat from G1 and G2 was infected with 1.25 × $ 10^{5} $ trypomastigotes. Cerebrospinal fluid (CSF) analysis and investigation of T. vivax was performed at the $ 15^{th} $ day post-infection (dpi) in G1 goats and on the fifth day after the manifestation of nervous system infection signs in G2 goats. All goats were necropsied, and CNS fragments from G1 and G2 goats were evaluated by PCR for the determination of T. vivax. Hyperthermia, anemia and parasitemia were observed from the fifth dpi for G1 and G2, with the highest parasitemia peak between the seventh and $ 21^{st} $ dpi. Nervous system infection signs were observed in three G2 goats between the $ 30^{th} $ and $ 35^{th} $ dpi. CSF analysis revealed the presence of T. vivax for G2. Meningitis and meningoencephalitis were diagnosed in G2. PCR were positive for T. vivax in all the samples tested. In conclusion, T. vivax may reach the nervous tissue resulting in immune response from the host, which is the cause of progressive clinical and pathological manifestations of the CNS in experimentally infected goats. Meningoencephalitis (dpeaa)DE-He213 Bruxism (dpeaa)DE-He213 Central Nervous System Tissue (dpeaa)DE-He213 Central Nervous System Lesion (dpeaa)DE-He213 Cerebellar White Matter (dpeaa)DE-He213 Rodrigues, Carla MF verfasserin aut García, Herakles A verfasserin aut Bezerra, Francisco SB verfasserin aut Olinda, Robério G verfasserin aut Teixeira, Marta MG verfasserin aut Soto-Blanco, Benito verfasserin aut Enthalten in Veterinary research London : BioMed Central, 1993 42(2011), 1 vom: 11. Mai (DE-627)312853653 (DE-600)2012391-7 1297-9716 nnns volume:42 year:2011 number:1 day:11 month:05 https://dx.doi.org/10.1186/1297-9716-42-63 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 46.00 ASE AR 42 2011 1 11 05
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author	Batista, Jael S
spellingShingle	Batista, Jael S ddc 630 bkl 46.00 misc Meningoencephalitis misc Bruxism misc Central Nervous System Tissue misc Central Nervous System Lesion misc Cerebellar White Matter Association of Trypanosoma vivax in extracellular sites with central nervous system lesions and changes in cerebrospinal fluid in experimentally infected goats
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topic_title	630 640 ASE 46.00 bkl Association of Trypanosoma vivax in extracellular sites with central nervous system lesions and changes in cerebrospinal fluid in experimentally infected goats Meningoencephalitis (dpeaa)DE-He213 Bruxism (dpeaa)DE-He213 Central Nervous System Tissue (dpeaa)DE-He213 Central Nervous System Lesion (dpeaa)DE-He213 Cerebellar White Matter (dpeaa)DE-He213
topic	ddc 630 bkl 46.00 misc Meningoencephalitis misc Bruxism misc Central Nervous System Tissue misc Central Nervous System Lesion misc Cerebellar White Matter
topic_unstemmed	ddc 630 bkl 46.00 misc Meningoencephalitis misc Bruxism misc Central Nervous System Tissue misc Central Nervous System Lesion misc Cerebellar White Matter
topic_browse	ddc 630 bkl 46.00 misc Meningoencephalitis misc Bruxism misc Central Nervous System Tissue misc Central Nervous System Lesion misc Cerebellar White Matter
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title	Association of Trypanosoma vivax in extracellular sites with central nervous system lesions and changes in cerebrospinal fluid in experimentally infected goats
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title_full	Association of Trypanosoma vivax in extracellular sites with central nervous system lesions and changes in cerebrospinal fluid in experimentally infected goats
author_sort	Batista, Jael S
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author_browse	Batista, Jael S Rodrigues, Carla MF García, Herakles A Bezerra, Francisco SB Olinda, Robério G Teixeira, Marta MG Soto-Blanco, Benito
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title_sort	association of trypanosoma vivax in extracellular sites with central nervous system lesions and changes in cerebrospinal fluid in experimentally infected goats
title_auth	Association of Trypanosoma vivax in extracellular sites with central nervous system lesions and changes in cerebrospinal fluid in experimentally infected goats
abstract	Abstract Changes in cerebrospinal fluid (CSF) and anatomical and histopathological central nervous system (CNS) lesions were evaluated, and the presence of Trypanosoma vivax in CNS tissues was investigated through PCR. Twelve adult male goats were divided into three groups (G): G1, infected with T. vivax and evaluated during the acute phase; G2, infected goats evaluated during the chronic phase; and G3, consisting of non-infected goats. Each goat from G1 and G2 was infected with 1.25 × $ 10^{5} $ trypomastigotes. Cerebrospinal fluid (CSF) analysis and investigation of T. vivax was performed at the $ 15^{th} $ day post-infection (dpi) in G1 goats and on the fifth day after the manifestation of nervous system infection signs in G2 goats. All goats were necropsied, and CNS fragments from G1 and G2 goats were evaluated by PCR for the determination of T. vivax. Hyperthermia, anemia and parasitemia were observed from the fifth dpi for G1 and G2, with the highest parasitemia peak between the seventh and $ 21^{st} $ dpi. Nervous system infection signs were observed in three G2 goats between the $ 30^{th} $ and $ 35^{th} $ dpi. CSF analysis revealed the presence of T. vivax for G2. Meningitis and meningoencephalitis were diagnosed in G2. PCR were positive for T. vivax in all the samples tested. In conclusion, T. vivax may reach the nervous tissue resulting in immune response from the host, which is the cause of progressive clinical and pathological manifestations of the CNS in experimentally infected goats.
abstractGer	Abstract Changes in cerebrospinal fluid (CSF) and anatomical and histopathological central nervous system (CNS) lesions were evaluated, and the presence of Trypanosoma vivax in CNS tissues was investigated through PCR. Twelve adult male goats were divided into three groups (G): G1, infected with T. vivax and evaluated during the acute phase; G2, infected goats evaluated during the chronic phase; and G3, consisting of non-infected goats. Each goat from G1 and G2 was infected with 1.25 × $ 10^{5} $ trypomastigotes. Cerebrospinal fluid (CSF) analysis and investigation of T. vivax was performed at the $ 15^{th} $ day post-infection (dpi) in G1 goats and on the fifth day after the manifestation of nervous system infection signs in G2 goats. All goats were necropsied, and CNS fragments from G1 and G2 goats were evaluated by PCR for the determination of T. vivax. Hyperthermia, anemia and parasitemia were observed from the fifth dpi for G1 and G2, with the highest parasitemia peak between the seventh and $ 21^{st} $ dpi. Nervous system infection signs were observed in three G2 goats between the $ 30^{th} $ and $ 35^{th} $ dpi. CSF analysis revealed the presence of T. vivax for G2. Meningitis and meningoencephalitis were diagnosed in G2. PCR were positive for T. vivax in all the samples tested. In conclusion, T. vivax may reach the nervous tissue resulting in immune response from the host, which is the cause of progressive clinical and pathological manifestations of the CNS in experimentally infected goats.
abstract_unstemmed	Abstract Changes in cerebrospinal fluid (CSF) and anatomical and histopathological central nervous system (CNS) lesions were evaluated, and the presence of Trypanosoma vivax in CNS tissues was investigated through PCR. Twelve adult male goats were divided into three groups (G): G1, infected with T. vivax and evaluated during the acute phase; G2, infected goats evaluated during the chronic phase; and G3, consisting of non-infected goats. Each goat from G1 and G2 was infected with 1.25 × $ 10^{5} $ trypomastigotes. Cerebrospinal fluid (CSF) analysis and investigation of T. vivax was performed at the $ 15^{th} $ day post-infection (dpi) in G1 goats and on the fifth day after the manifestation of nervous system infection signs in G2 goats. All goats were necropsied, and CNS fragments from G1 and G2 goats were evaluated by PCR for the determination of T. vivax. Hyperthermia, anemia and parasitemia were observed from the fifth dpi for G1 and G2, with the highest parasitemia peak between the seventh and $ 21^{st} $ dpi. Nervous system infection signs were observed in three G2 goats between the $ 30^{th} $ and $ 35^{th} $ dpi. CSF analysis revealed the presence of T. vivax for G2. Meningitis and meningoencephalitis were diagnosed in G2. PCR were positive for T. vivax in all the samples tested. In conclusion, T. vivax may reach the nervous tissue resulting in immune response from the host, which is the cause of progressive clinical and pathological manifestations of the CNS in experimentally infected goats.
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title_short	Association of Trypanosoma vivax in extracellular sites with central nervous system lesions and changes in cerebrospinal fluid in experimentally infected goats
url	https://dx.doi.org/10.1186/1297-9716-42-63
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author2	Rodrigues, Carla MF García, Herakles A Bezerra, Francisco SB Olinda, Robério G Teixeira, Marta MG Soto-Blanco, Benito
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up_date	2024-07-04T01:21:43.242Z
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Twelve adult male goats were divided into three groups (G): G1, infected with T. vivax and evaluated during the acute phase; G2, infected goats evaluated during the chronic phase; and G3, consisting of non-infected goats. Each goat from G1 and G2 was infected with 1.25 × $ 10^{5} $ trypomastigotes. Cerebrospinal fluid (CSF) analysis and investigation of T. vivax was performed at the $ 15^{th} $ day post-infection (dpi) in G1 goats and on the fifth day after the manifestation of nervous system infection signs in G2 goats. All goats were necropsied, and CNS fragments from G1 and G2 goats were evaluated by PCR for the determination of T. vivax. Hyperthermia, anemia and parasitemia were observed from the fifth dpi for G1 and G2, with the highest parasitemia peak between the seventh and $ 21^{st} $ dpi. Nervous system infection signs were observed in three G2 goats between the $ 30^{th} $ and $ 35^{th} $ dpi. CSF analysis revealed the presence of T. vivax for G2. Meningitis and meningoencephalitis were diagnosed in G2. PCR were positive for T. vivax in all the samples tested. 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Association of Trypanosoma vivax in extracellular sites with central nervous system lesions and changes in cerebrospinal fluid in experimentally infected goats

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