Association study in naturally infected helminth layers shows evidence for influence of interferon-gamma gene variants on Ascaridia galli worm burden

Abstract Single nucleotide polymorphisms (SNPs) in the genes for interleukin-4, -13 and interferon-gamma, and 21 additional SNPs which previously had been significantly associated with immune traits in the chicken, were genotyped in white and brown layer hens and analyzed for their association with...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Lühken, Gesine [verfasserIn] Gauly, Matthias [verfasserIn] Kaufmann, Falko [verfasserIn] Erhardt, Georg [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2011

Schlagwörter:	Single Nucleotide Polymorphism Minor Allele Frequency Single Nucleotide Polymorphism Genotype Immune Trait Total Worm Burden

Übergeordnetes Werk:	Enthalten in: Veterinary research - London : BioMed Central, 1993, 42(2011), 1 vom: 12. Juli
Übergeordnetes Werk:	volume:42 ; year:2011 ; number:1 ; day:12 ; month:07

Links:	Volltext

DOI / URN:	10.1186/1297-9716-42-84

Katalog-ID:	SPR031814743

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520			\|a Abstract Single nucleotide polymorphisms (SNPs) in the genes for interleukin-4, -13 and interferon-gamma, and 21 additional SNPs which previously had been significantly associated with immune traits in the chicken, were genotyped in white and brown layer hens and analyzed for their association with helminth burden following natural infections. A nucleotide substitution located upstream of the promoter of the interferon-gamma gene was significantly associated with the log transformed number of Ascaridia galli in the brown layer line (genotype CC: 6.4 ± 1.0 worms; genotype CT: 11.7 ± 2.2 worms). Therefore, IFNG seems to be a promising candidate gene for further studies on helminth resistance in the chicken.
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allfields	10.1186/1297-9716-42-84 doi (DE-627)SPR031814743 (SPR)1297-9716-42-84-e DE-627 ger DE-627 rakwb eng 630 640 ASE 46.00 bkl Lühken, Gesine verfasserin aut Association study in naturally infected helminth layers shows evidence for influence of interferon-gamma gene variants on Ascaridia galli worm burden 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Single nucleotide polymorphisms (SNPs) in the genes for interleukin-4, -13 and interferon-gamma, and 21 additional SNPs which previously had been significantly associated with immune traits in the chicken, were genotyped in white and brown layer hens and analyzed for their association with helminth burden following natural infections. A nucleotide substitution located upstream of the promoter of the interferon-gamma gene was significantly associated with the log transformed number of Ascaridia galli in the brown layer line (genotype CC: 6.4 ± 1.0 worms; genotype CT: 11.7 ± 2.2 worms). Therefore, IFNG seems to be a promising candidate gene for further studies on helminth resistance in the chicken. Single Nucleotide Polymorphism (dpeaa)DE-He213 Minor Allele Frequency (dpeaa)DE-He213 Single Nucleotide Polymorphism Genotype (dpeaa)DE-He213 Immune Trait (dpeaa)DE-He213 Total Worm Burden (dpeaa)DE-He213 Gauly, Matthias verfasserin aut Kaufmann, Falko verfasserin aut Erhardt, Georg verfasserin aut Enthalten in Veterinary research London : BioMed Central, 1993 42(2011), 1 vom: 12. Juli (DE-627)312853653 (DE-600)2012391-7 1297-9716 nnns volume:42 year:2011 number:1 day:12 month:07 https://dx.doi.org/10.1186/1297-9716-42-84 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 46.00 ASE AR 42 2011 1 12 07
spelling	10.1186/1297-9716-42-84 doi (DE-627)SPR031814743 (SPR)1297-9716-42-84-e DE-627 ger DE-627 rakwb eng 630 640 ASE 46.00 bkl Lühken, Gesine verfasserin aut Association study in naturally infected helminth layers shows evidence for influence of interferon-gamma gene variants on Ascaridia galli worm burden 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Single nucleotide polymorphisms (SNPs) in the genes for interleukin-4, -13 and interferon-gamma, and 21 additional SNPs which previously had been significantly associated with immune traits in the chicken, were genotyped in white and brown layer hens and analyzed for their association with helminth burden following natural infections. A nucleotide substitution located upstream of the promoter of the interferon-gamma gene was significantly associated with the log transformed number of Ascaridia galli in the brown layer line (genotype CC: 6.4 ± 1.0 worms; genotype CT: 11.7 ± 2.2 worms). Therefore, IFNG seems to be a promising candidate gene for further studies on helminth resistance in the chicken. Single Nucleotide Polymorphism (dpeaa)DE-He213 Minor Allele Frequency (dpeaa)DE-He213 Single Nucleotide Polymorphism Genotype (dpeaa)DE-He213 Immune Trait (dpeaa)DE-He213 Total Worm Burden (dpeaa)DE-He213 Gauly, Matthias verfasserin aut Kaufmann, Falko verfasserin aut Erhardt, Georg verfasserin aut Enthalten in Veterinary research London : BioMed Central, 1993 42(2011), 1 vom: 12. Juli (DE-627)312853653 (DE-600)2012391-7 1297-9716 nnns volume:42 year:2011 number:1 day:12 month:07 https://dx.doi.org/10.1186/1297-9716-42-84 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 46.00 ASE AR 42 2011 1 12 07
allfields_unstemmed	10.1186/1297-9716-42-84 doi (DE-627)SPR031814743 (SPR)1297-9716-42-84-e DE-627 ger DE-627 rakwb eng 630 640 ASE 46.00 bkl Lühken, Gesine verfasserin aut Association study in naturally infected helminth layers shows evidence for influence of interferon-gamma gene variants on Ascaridia galli worm burden 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Single nucleotide polymorphisms (SNPs) in the genes for interleukin-4, -13 and interferon-gamma, and 21 additional SNPs which previously had been significantly associated with immune traits in the chicken, were genotyped in white and brown layer hens and analyzed for their association with helminth burden following natural infections. A nucleotide substitution located upstream of the promoter of the interferon-gamma gene was significantly associated with the log transformed number of Ascaridia galli in the brown layer line (genotype CC: 6.4 ± 1.0 worms; genotype CT: 11.7 ± 2.2 worms). Therefore, IFNG seems to be a promising candidate gene for further studies on helminth resistance in the chicken. Single Nucleotide Polymorphism (dpeaa)DE-He213 Minor Allele Frequency (dpeaa)DE-He213 Single Nucleotide Polymorphism Genotype (dpeaa)DE-He213 Immune Trait (dpeaa)DE-He213 Total Worm Burden (dpeaa)DE-He213 Gauly, Matthias verfasserin aut Kaufmann, Falko verfasserin aut Erhardt, Georg verfasserin aut Enthalten in Veterinary research London : BioMed Central, 1993 42(2011), 1 vom: 12. Juli (DE-627)312853653 (DE-600)2012391-7 1297-9716 nnns volume:42 year:2011 number:1 day:12 month:07 https://dx.doi.org/10.1186/1297-9716-42-84 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 46.00 ASE AR 42 2011 1 12 07
allfieldsGer	10.1186/1297-9716-42-84 doi (DE-627)SPR031814743 (SPR)1297-9716-42-84-e DE-627 ger DE-627 rakwb eng 630 640 ASE 46.00 bkl Lühken, Gesine verfasserin aut Association study in naturally infected helminth layers shows evidence for influence of interferon-gamma gene variants on Ascaridia galli worm burden 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Single nucleotide polymorphisms (SNPs) in the genes for interleukin-4, -13 and interferon-gamma, and 21 additional SNPs which previously had been significantly associated with immune traits in the chicken, were genotyped in white and brown layer hens and analyzed for their association with helminth burden following natural infections. A nucleotide substitution located upstream of the promoter of the interferon-gamma gene was significantly associated with the log transformed number of Ascaridia galli in the brown layer line (genotype CC: 6.4 ± 1.0 worms; genotype CT: 11.7 ± 2.2 worms). Therefore, IFNG seems to be a promising candidate gene for further studies on helminth resistance in the chicken. Single Nucleotide Polymorphism (dpeaa)DE-He213 Minor Allele Frequency (dpeaa)DE-He213 Single Nucleotide Polymorphism Genotype (dpeaa)DE-He213 Immune Trait (dpeaa)DE-He213 Total Worm Burden (dpeaa)DE-He213 Gauly, Matthias verfasserin aut Kaufmann, Falko verfasserin aut Erhardt, Georg verfasserin aut Enthalten in Veterinary research London : BioMed Central, 1993 42(2011), 1 vom: 12. Juli (DE-627)312853653 (DE-600)2012391-7 1297-9716 nnns volume:42 year:2011 number:1 day:12 month:07 https://dx.doi.org/10.1186/1297-9716-42-84 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 46.00 ASE AR 42 2011 1 12 07
allfieldsSound	10.1186/1297-9716-42-84 doi (DE-627)SPR031814743 (SPR)1297-9716-42-84-e DE-627 ger DE-627 rakwb eng 630 640 ASE 46.00 bkl Lühken, Gesine verfasserin aut Association study in naturally infected helminth layers shows evidence for influence of interferon-gamma gene variants on Ascaridia galli worm burden 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Single nucleotide polymorphisms (SNPs) in the genes for interleukin-4, -13 and interferon-gamma, and 21 additional SNPs which previously had been significantly associated with immune traits in the chicken, were genotyped in white and brown layer hens and analyzed for their association with helminth burden following natural infections. A nucleotide substitution located upstream of the promoter of the interferon-gamma gene was significantly associated with the log transformed number of Ascaridia galli in the brown layer line (genotype CC: 6.4 ± 1.0 worms; genotype CT: 11.7 ± 2.2 worms). Therefore, IFNG seems to be a promising candidate gene for further studies on helminth resistance in the chicken. Single Nucleotide Polymorphism (dpeaa)DE-He213 Minor Allele Frequency (dpeaa)DE-He213 Single Nucleotide Polymorphism Genotype (dpeaa)DE-He213 Immune Trait (dpeaa)DE-He213 Total Worm Burden (dpeaa)DE-He213 Gauly, Matthias verfasserin aut Kaufmann, Falko verfasserin aut Erhardt, Georg verfasserin aut Enthalten in Veterinary research London : BioMed Central, 1993 42(2011), 1 vom: 12. Juli (DE-627)312853653 (DE-600)2012391-7 1297-9716 nnns volume:42 year:2011 number:1 day:12 month:07 https://dx.doi.org/10.1186/1297-9716-42-84 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 46.00 ASE AR 42 2011 1 12 07
language	English
source	Enthalten in Veterinary research 42(2011), 1 vom: 12. Juli volume:42 year:2011 number:1 day:12 month:07
sourceStr	Enthalten in Veterinary research 42(2011), 1 vom: 12. Juli volume:42 year:2011 number:1 day:12 month:07
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Single Nucleotide Polymorphism Minor Allele Frequency Single Nucleotide Polymorphism Genotype Immune Trait Total Worm Burden
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container_title	Veterinary research
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author	Lühken, Gesine
spellingShingle	Lühken, Gesine ddc 630 bkl 46.00 misc Single Nucleotide Polymorphism misc Minor Allele Frequency misc Single Nucleotide Polymorphism Genotype misc Immune Trait misc Total Worm Burden Association study in naturally infected helminth layers shows evidence for influence of interferon-gamma gene variants on Ascaridia galli worm burden
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topic_title	630 640 ASE 46.00 bkl Association study in naturally infected helminth layers shows evidence for influence of interferon-gamma gene variants on Ascaridia galli worm burden Single Nucleotide Polymorphism (dpeaa)DE-He213 Minor Allele Frequency (dpeaa)DE-He213 Single Nucleotide Polymorphism Genotype (dpeaa)DE-He213 Immune Trait (dpeaa)DE-He213 Total Worm Burden (dpeaa)DE-He213
topic	ddc 630 bkl 46.00 misc Single Nucleotide Polymorphism misc Minor Allele Frequency misc Single Nucleotide Polymorphism Genotype misc Immune Trait misc Total Worm Burden
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title	Association study in naturally infected helminth layers shows evidence for influence of interferon-gamma gene variants on Ascaridia galli worm burden
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title_full	Association study in naturally infected helminth layers shows evidence for influence of interferon-gamma gene variants on Ascaridia galli worm burden
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title_sort	association study in naturally infected helminth layers shows evidence for influence of interferon-gamma gene variants on ascaridia galli worm burden
title_auth	Association study in naturally infected helminth layers shows evidence for influence of interferon-gamma gene variants on Ascaridia galli worm burden
abstract	Abstract Single nucleotide polymorphisms (SNPs) in the genes for interleukin-4, -13 and interferon-gamma, and 21 additional SNPs which previously had been significantly associated with immune traits in the chicken, were genotyped in white and brown layer hens and analyzed for their association with helminth burden following natural infections. A nucleotide substitution located upstream of the promoter of the interferon-gamma gene was significantly associated with the log transformed number of Ascaridia galli in the brown layer line (genotype CC: 6.4 ± 1.0 worms; genotype CT: 11.7 ± 2.2 worms). Therefore, IFNG seems to be a promising candidate gene for further studies on helminth resistance in the chicken.
abstractGer	Abstract Single nucleotide polymorphisms (SNPs) in the genes for interleukin-4, -13 and interferon-gamma, and 21 additional SNPs which previously had been significantly associated with immune traits in the chicken, were genotyped in white and brown layer hens and analyzed for their association with helminth burden following natural infections. A nucleotide substitution located upstream of the promoter of the interferon-gamma gene was significantly associated with the log transformed number of Ascaridia galli in the brown layer line (genotype CC: 6.4 ± 1.0 worms; genotype CT: 11.7 ± 2.2 worms). Therefore, IFNG seems to be a promising candidate gene for further studies on helminth resistance in the chicken.
abstract_unstemmed	Abstract Single nucleotide polymorphisms (SNPs) in the genes for interleukin-4, -13 and interferon-gamma, and 21 additional SNPs which previously had been significantly associated with immune traits in the chicken, were genotyped in white and brown layer hens and analyzed for their association with helminth burden following natural infections. A nucleotide substitution located upstream of the promoter of the interferon-gamma gene was significantly associated with the log transformed number of Ascaridia galli in the brown layer line (genotype CC: 6.4 ± 1.0 worms; genotype CT: 11.7 ± 2.2 worms). Therefore, IFNG seems to be a promising candidate gene for further studies on helminth resistance in the chicken.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
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title_short	Association study in naturally infected helminth layers shows evidence for influence of interferon-gamma gene variants on Ascaridia galli worm burden
url	https://dx.doi.org/10.1186/1297-9716-42-84
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up_date	2024-07-04T01:21:46.859Z
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Association study in naturally infected helminth layers shows evidence for influence of interferon-gamma gene variants on Ascaridia galli worm burden

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