Schmallenberg virus challenge models in cattle: infectious serum or culture-grown virus?
Abstract Schmallenberg virus (SBV), discovered in Europe in 2011, causes mild transient disease in adult ruminants, but fetal infection can lead to severe malformation in cattle, sheep and goats. To elucidate the pathogenesis of this novel orthobunyavirus, considerable efforts are required. A reliab...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Wernike, Kerstin [verfasserIn] Eschbaumer, Michael [verfasserIn] Breithaupt, Angele [verfasserIn] Hoffmann, Bernd [verfasserIn] Beer, Martin [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2012 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Veterinary research - London : BioMed Central, 1993, 43(2012), 1 vom: 11. Dez. |
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| Übergeordnetes Werk: |
volume:43 ; year:2012 ; number:1 ; day:11 ; month:12 |
| Links: |
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| DOI / URN: |
10.1186/1297-9716-43-84 |
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SPR031815812 |
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| 520 | |a Abstract Schmallenberg virus (SBV), discovered in Europe in 2011, causes mild transient disease in adult ruminants, but fetal infection can lead to severe malformation in cattle, sheep and goats. To elucidate the pathogenesis of this novel orthobunyavirus, considerable efforts are required. A reliable and standardized infection model is essential for in vivo studies. In the present study, two groups of four cattle were inoculated with either serum passaged in cattle only or cell culture-grown virus. The replication of culture-grown SBV in cattle was reduced compared to virus inoculated via infectious serum. In a second experiment, the infectious serum was titrated in calves; the tested batch contained $ 10^{2.83} $ infectious doses per mL. Hence, serum-borne virus that was only passaged in the natural host is a suitable option for a standardized SBV infection model. | ||
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10.1186/1297-9716-43-84 doi (DE-627)SPR031815812 (SPR)1297-9716-43-84-e DE-627 ger DE-627 rakwb eng 630 640 ASE 46.00 bkl Wernike, Kerstin verfasserin aut Schmallenberg virus challenge models in cattle: infectious serum or culture-grown virus? 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Schmallenberg virus (SBV), discovered in Europe in 2011, causes mild transient disease in adult ruminants, but fetal infection can lead to severe malformation in cattle, sheep and goats. To elucidate the pathogenesis of this novel orthobunyavirus, considerable efforts are required. A reliable and standardized infection model is essential for in vivo studies. In the present study, two groups of four cattle were inoculated with either serum passaged in cattle only or cell culture-grown virus. The replication of culture-grown SBV in cattle was reduced compared to virus inoculated via infectious serum. In a second experiment, the infectious serum was titrated in calves; the tested batch contained $ 10^{2.83} $ infectious doses per mL. Hence, serum-borne virus that was only passaged in the natural host is a suitable option for a standardized SBV infection model. Rift Valley Fever (dpeaa)DE-He213 Rift Valley Fever Virus (dpeaa)DE-He213 Baby Hamster Kidney Cell (dpeaa)DE-He213 Undiluted Serum (dpeaa)DE-He213 Epizootic Hemorrhagic Disease Virus (dpeaa)DE-He213 Eschbaumer, Michael verfasserin aut Breithaupt, Angele verfasserin aut Hoffmann, Bernd verfasserin aut Beer, Martin verfasserin aut Enthalten in Veterinary research London : BioMed Central, 1993 43(2012), 1 vom: 11. Dez. (DE-627)312853653 (DE-600)2012391-7 1297-9716 nnns volume:43 year:2012 number:1 day:11 month:12 https://dx.doi.org/10.1186/1297-9716-43-84 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 46.00 ASE AR 43 2012 1 11 12 |
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10.1186/1297-9716-43-84 doi (DE-627)SPR031815812 (SPR)1297-9716-43-84-e DE-627 ger DE-627 rakwb eng 630 640 ASE 46.00 bkl Wernike, Kerstin verfasserin aut Schmallenberg virus challenge models in cattle: infectious serum or culture-grown virus? 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Schmallenberg virus (SBV), discovered in Europe in 2011, causes mild transient disease in adult ruminants, but fetal infection can lead to severe malformation in cattle, sheep and goats. To elucidate the pathogenesis of this novel orthobunyavirus, considerable efforts are required. A reliable and standardized infection model is essential for in vivo studies. In the present study, two groups of four cattle were inoculated with either serum passaged in cattle only or cell culture-grown virus. The replication of culture-grown SBV in cattle was reduced compared to virus inoculated via infectious serum. In a second experiment, the infectious serum was titrated in calves; the tested batch contained $ 10^{2.83} $ infectious doses per mL. Hence, serum-borne virus that was only passaged in the natural host is a suitable option for a standardized SBV infection model. Rift Valley Fever (dpeaa)DE-He213 Rift Valley Fever Virus (dpeaa)DE-He213 Baby Hamster Kidney Cell (dpeaa)DE-He213 Undiluted Serum (dpeaa)DE-He213 Epizootic Hemorrhagic Disease Virus (dpeaa)DE-He213 Eschbaumer, Michael verfasserin aut Breithaupt, Angele verfasserin aut Hoffmann, Bernd verfasserin aut Beer, Martin verfasserin aut Enthalten in Veterinary research London : BioMed Central, 1993 43(2012), 1 vom: 11. Dez. (DE-627)312853653 (DE-600)2012391-7 1297-9716 nnns volume:43 year:2012 number:1 day:11 month:12 https://dx.doi.org/10.1186/1297-9716-43-84 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 46.00 ASE AR 43 2012 1 11 12 |
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10.1186/1297-9716-43-84 doi (DE-627)SPR031815812 (SPR)1297-9716-43-84-e DE-627 ger DE-627 rakwb eng 630 640 ASE 46.00 bkl Wernike, Kerstin verfasserin aut Schmallenberg virus challenge models in cattle: infectious serum or culture-grown virus? 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Schmallenberg virus (SBV), discovered in Europe in 2011, causes mild transient disease in adult ruminants, but fetal infection can lead to severe malformation in cattle, sheep and goats. To elucidate the pathogenesis of this novel orthobunyavirus, considerable efforts are required. A reliable and standardized infection model is essential for in vivo studies. In the present study, two groups of four cattle were inoculated with either serum passaged in cattle only or cell culture-grown virus. The replication of culture-grown SBV in cattle was reduced compared to virus inoculated via infectious serum. In a second experiment, the infectious serum was titrated in calves; the tested batch contained $ 10^{2.83} $ infectious doses per mL. Hence, serum-borne virus that was only passaged in the natural host is a suitable option for a standardized SBV infection model. Rift Valley Fever (dpeaa)DE-He213 Rift Valley Fever Virus (dpeaa)DE-He213 Baby Hamster Kidney Cell (dpeaa)DE-He213 Undiluted Serum (dpeaa)DE-He213 Epizootic Hemorrhagic Disease Virus (dpeaa)DE-He213 Eschbaumer, Michael verfasserin aut Breithaupt, Angele verfasserin aut Hoffmann, Bernd verfasserin aut Beer, Martin verfasserin aut Enthalten in Veterinary research London : BioMed Central, 1993 43(2012), 1 vom: 11. Dez. (DE-627)312853653 (DE-600)2012391-7 1297-9716 nnns volume:43 year:2012 number:1 day:11 month:12 https://dx.doi.org/10.1186/1297-9716-43-84 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 46.00 ASE AR 43 2012 1 11 12 |
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10.1186/1297-9716-43-84 doi (DE-627)SPR031815812 (SPR)1297-9716-43-84-e DE-627 ger DE-627 rakwb eng 630 640 ASE 46.00 bkl Wernike, Kerstin verfasserin aut Schmallenberg virus challenge models in cattle: infectious serum or culture-grown virus? 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Schmallenberg virus (SBV), discovered in Europe in 2011, causes mild transient disease in adult ruminants, but fetal infection can lead to severe malformation in cattle, sheep and goats. To elucidate the pathogenesis of this novel orthobunyavirus, considerable efforts are required. A reliable and standardized infection model is essential for in vivo studies. In the present study, two groups of four cattle were inoculated with either serum passaged in cattle only or cell culture-grown virus. The replication of culture-grown SBV in cattle was reduced compared to virus inoculated via infectious serum. In a second experiment, the infectious serum was titrated in calves; the tested batch contained $ 10^{2.83} $ infectious doses per mL. Hence, serum-borne virus that was only passaged in the natural host is a suitable option for a standardized SBV infection model. Rift Valley Fever (dpeaa)DE-He213 Rift Valley Fever Virus (dpeaa)DE-He213 Baby Hamster Kidney Cell (dpeaa)DE-He213 Undiluted Serum (dpeaa)DE-He213 Epizootic Hemorrhagic Disease Virus (dpeaa)DE-He213 Eschbaumer, Michael verfasserin aut Breithaupt, Angele verfasserin aut Hoffmann, Bernd verfasserin aut Beer, Martin verfasserin aut Enthalten in Veterinary research London : BioMed Central, 1993 43(2012), 1 vom: 11. Dez. (DE-627)312853653 (DE-600)2012391-7 1297-9716 nnns volume:43 year:2012 number:1 day:11 month:12 https://dx.doi.org/10.1186/1297-9716-43-84 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 46.00 ASE AR 43 2012 1 11 12 |
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10.1186/1297-9716-43-84 doi (DE-627)SPR031815812 (SPR)1297-9716-43-84-e DE-627 ger DE-627 rakwb eng 630 640 ASE 46.00 bkl Wernike, Kerstin verfasserin aut Schmallenberg virus challenge models in cattle: infectious serum or culture-grown virus? 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Schmallenberg virus (SBV), discovered in Europe in 2011, causes mild transient disease in adult ruminants, but fetal infection can lead to severe malformation in cattle, sheep and goats. To elucidate the pathogenesis of this novel orthobunyavirus, considerable efforts are required. A reliable and standardized infection model is essential for in vivo studies. In the present study, two groups of four cattle were inoculated with either serum passaged in cattle only or cell culture-grown virus. The replication of culture-grown SBV in cattle was reduced compared to virus inoculated via infectious serum. In a second experiment, the infectious serum was titrated in calves; the tested batch contained $ 10^{2.83} $ infectious doses per mL. Hence, serum-borne virus that was only passaged in the natural host is a suitable option for a standardized SBV infection model. Rift Valley Fever (dpeaa)DE-He213 Rift Valley Fever Virus (dpeaa)DE-He213 Baby Hamster Kidney Cell (dpeaa)DE-He213 Undiluted Serum (dpeaa)DE-He213 Epizootic Hemorrhagic Disease Virus (dpeaa)DE-He213 Eschbaumer, Michael verfasserin aut Breithaupt, Angele verfasserin aut Hoffmann, Bernd verfasserin aut Beer, Martin verfasserin aut Enthalten in Veterinary research London : BioMed Central, 1993 43(2012), 1 vom: 11. Dez. (DE-627)312853653 (DE-600)2012391-7 1297-9716 nnns volume:43 year:2012 number:1 day:11 month:12 https://dx.doi.org/10.1186/1297-9716-43-84 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 46.00 ASE AR 43 2012 1 11 12 |
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Wernike, Kerstin |
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schmallenberg virus challenge models in cattle: infectious serum or culture-grown virus? |
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Schmallenberg virus challenge models in cattle: infectious serum or culture-grown virus? |
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Abstract Schmallenberg virus (SBV), discovered in Europe in 2011, causes mild transient disease in adult ruminants, but fetal infection can lead to severe malformation in cattle, sheep and goats. To elucidate the pathogenesis of this novel orthobunyavirus, considerable efforts are required. A reliable and standardized infection model is essential for in vivo studies. In the present study, two groups of four cattle were inoculated with either serum passaged in cattle only or cell culture-grown virus. The replication of culture-grown SBV in cattle was reduced compared to virus inoculated via infectious serum. In a second experiment, the infectious serum was titrated in calves; the tested batch contained $ 10^{2.83} $ infectious doses per mL. Hence, serum-borne virus that was only passaged in the natural host is a suitable option for a standardized SBV infection model. |
| abstractGer |
Abstract Schmallenberg virus (SBV), discovered in Europe in 2011, causes mild transient disease in adult ruminants, but fetal infection can lead to severe malformation in cattle, sheep and goats. To elucidate the pathogenesis of this novel orthobunyavirus, considerable efforts are required. A reliable and standardized infection model is essential for in vivo studies. In the present study, two groups of four cattle were inoculated with either serum passaged in cattle only or cell culture-grown virus. The replication of culture-grown SBV in cattle was reduced compared to virus inoculated via infectious serum. In a second experiment, the infectious serum was titrated in calves; the tested batch contained $ 10^{2.83} $ infectious doses per mL. Hence, serum-borne virus that was only passaged in the natural host is a suitable option for a standardized SBV infection model. |
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Abstract Schmallenberg virus (SBV), discovered in Europe in 2011, causes mild transient disease in adult ruminants, but fetal infection can lead to severe malformation in cattle, sheep and goats. To elucidate the pathogenesis of this novel orthobunyavirus, considerable efforts are required. A reliable and standardized infection model is essential for in vivo studies. In the present study, two groups of four cattle were inoculated with either serum passaged in cattle only or cell culture-grown virus. The replication of culture-grown SBV in cattle was reduced compared to virus inoculated via infectious serum. In a second experiment, the infectious serum was titrated in calves; the tested batch contained $ 10^{2.83} $ infectious doses per mL. Hence, serum-borne virus that was only passaged in the natural host is a suitable option for a standardized SBV infection model. |
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