Description of the interaction between Candida albicans and macrophages by mixed and quantitative proteome analysis without isolation
Abstract Candida albicans is an opportunistic pathogen that causes fatal diseases in immunocompromised hosts. Host resistance against C. albicans relies on ingestion of the pathogen by macrophages. Analysis of the escaping behavior of C. albicans from macrophages is required to understand the onset...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Kitahara, Nao [verfasserIn] Morisaka, Hironobu [verfasserIn] Aoki, Wataru [verfasserIn] Takeda, Yumiko [verfasserIn] Shibasaki, Seiji [verfasserIn] Kuroda, Kouichi [verfasserIn] Ueda, Mitsuyoshi [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: AMB express - Heidelberg : Springer, 2011, 5(2015), 1 vom: 16. Juli |
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| Übergeordnetes Werk: |
volume:5 ; year:2015 ; number:1 ; day:16 ; month:07 |
| Links: |
|---|
| DOI / URN: |
10.1186/s13568-015-0127-2 |
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| Katalog-ID: |
SPR031828817 |
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| 520 | |a Abstract Candida albicans is an opportunistic pathogen that causes fatal diseases in immunocompromised hosts. Host resistance against C. albicans relies on ingestion of the pathogen by macrophages. Analysis of the escaping behavior of C. albicans from macrophages is required to understand the onset of systemic candidiasis. In this study, native interactions of C. albicans with macrophages were investigated by proteome analysis using high efficiency of long monolithic silica capillary column. Using this system, we developed a method of “mixed and quantitative proteome analysis” in which C. albicans and macrophages were simultaneously analyzed by nanoLC–MS/MS without the need to isolate the two individual living cells. Two hundred twenty-seven proteins from C. albicans and five proteins from macrophages were identified as candidate interaction-specific molecules. C. albicans seemed to produce glucose through a β-oxidation pathway, a glyoxylate cycle, and gluconeogenesis for escape from macrophages. Up-regulation of stress-related and candidate pathogenic proteins in C. albicans indicated how C. albicans endured the harsh environment inside the macrophages. Down-regulation of apoptosis-associated protein NOA1- and chaperone HSPA1A-syntheses in macrophage indicated that C. albicans was able to escape from macrophages in part by suppressing the production of these macrophage proteins. | ||
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| 650 | 4 | |a Chaperone |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Morisaka, Hironobu |e verfasserin |4 aut | |
| 700 | 1 | |a Aoki, Wataru |e verfasserin |4 aut | |
| 700 | 1 | |a Takeda, Yumiko |e verfasserin |4 aut | |
| 700 | 1 | |a Shibasaki, Seiji |e verfasserin |4 aut | |
| 700 | 1 | |a Kuroda, Kouichi |e verfasserin |4 aut | |
| 700 | 1 | |a Ueda, Mitsuyoshi |e verfasserin |4 aut | |
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10.1186/s13568-015-0127-2 doi (DE-627)SPR031828817 (SPR)s13568-015-0127-2-e DE-627 ger DE-627 rakwb eng 570 ASE 58.30 bkl Kitahara, Nao verfasserin aut Description of the interaction between Candida albicans and macrophages by mixed and quantitative proteome analysis without isolation 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Candida albicans is an opportunistic pathogen that causes fatal diseases in immunocompromised hosts. Host resistance against C. albicans relies on ingestion of the pathogen by macrophages. Analysis of the escaping behavior of C. albicans from macrophages is required to understand the onset of systemic candidiasis. In this study, native interactions of C. albicans with macrophages were investigated by proteome analysis using high efficiency of long monolithic silica capillary column. Using this system, we developed a method of “mixed and quantitative proteome analysis” in which C. albicans and macrophages were simultaneously analyzed by nanoLC–MS/MS without the need to isolate the two individual living cells. Two hundred twenty-seven proteins from C. albicans and five proteins from macrophages were identified as candidate interaction-specific molecules. C. albicans seemed to produce glucose through a β-oxidation pathway, a glyoxylate cycle, and gluconeogenesis for escape from macrophages. Up-regulation of stress-related and candidate pathogenic proteins in C. albicans indicated how C. albicans endured the harsh environment inside the macrophages. Down-regulation of apoptosis-associated protein NOA1- and chaperone HSPA1A-syntheses in macrophage indicated that C. albicans was able to escape from macrophages in part by suppressing the production of these macrophage proteins. Macrophage (dpeaa)DE-He213 Mixed proteome analysis (dpeaa)DE-He213 Quantitative proteome analysis (dpeaa)DE-He213 Apoptosis (dpeaa)DE-He213 Chaperone (dpeaa)DE-He213 Morisaka, Hironobu verfasserin aut Aoki, Wataru verfasserin aut Takeda, Yumiko verfasserin aut Shibasaki, Seiji verfasserin aut Kuroda, Kouichi verfasserin aut Ueda, Mitsuyoshi verfasserin aut Enthalten in AMB express Heidelberg : Springer, 2011 5(2015), 1 vom: 16. Juli (DE-627)665672926 (DE-600)2621432-5 2191-0855 nnns volume:5 year:2015 number:1 day:16 month:07 https://dx.doi.org/10.1186/s13568-015-0127-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 58.30 ASE AR 5 2015 1 16 07 |
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10.1186/s13568-015-0127-2 doi (DE-627)SPR031828817 (SPR)s13568-015-0127-2-e DE-627 ger DE-627 rakwb eng 570 ASE 58.30 bkl Kitahara, Nao verfasserin aut Description of the interaction between Candida albicans and macrophages by mixed and quantitative proteome analysis without isolation 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Candida albicans is an opportunistic pathogen that causes fatal diseases in immunocompromised hosts. Host resistance against C. albicans relies on ingestion of the pathogen by macrophages. Analysis of the escaping behavior of C. albicans from macrophages is required to understand the onset of systemic candidiasis. In this study, native interactions of C. albicans with macrophages were investigated by proteome analysis using high efficiency of long monolithic silica capillary column. Using this system, we developed a method of “mixed and quantitative proteome analysis” in which C. albicans and macrophages were simultaneously analyzed by nanoLC–MS/MS without the need to isolate the two individual living cells. Two hundred twenty-seven proteins from C. albicans and five proteins from macrophages were identified as candidate interaction-specific molecules. C. albicans seemed to produce glucose through a β-oxidation pathway, a glyoxylate cycle, and gluconeogenesis for escape from macrophages. Up-regulation of stress-related and candidate pathogenic proteins in C. albicans indicated how C. albicans endured the harsh environment inside the macrophages. Down-regulation of apoptosis-associated protein NOA1- and chaperone HSPA1A-syntheses in macrophage indicated that C. albicans was able to escape from macrophages in part by suppressing the production of these macrophage proteins. Macrophage (dpeaa)DE-He213 Mixed proteome analysis (dpeaa)DE-He213 Quantitative proteome analysis (dpeaa)DE-He213 Apoptosis (dpeaa)DE-He213 Chaperone (dpeaa)DE-He213 Morisaka, Hironobu verfasserin aut Aoki, Wataru verfasserin aut Takeda, Yumiko verfasserin aut Shibasaki, Seiji verfasserin aut Kuroda, Kouichi verfasserin aut Ueda, Mitsuyoshi verfasserin aut Enthalten in AMB express Heidelberg : Springer, 2011 5(2015), 1 vom: 16. Juli (DE-627)665672926 (DE-600)2621432-5 2191-0855 nnns volume:5 year:2015 number:1 day:16 month:07 https://dx.doi.org/10.1186/s13568-015-0127-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 58.30 ASE AR 5 2015 1 16 07 |
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10.1186/s13568-015-0127-2 doi (DE-627)SPR031828817 (SPR)s13568-015-0127-2-e DE-627 ger DE-627 rakwb eng 570 ASE 58.30 bkl Kitahara, Nao verfasserin aut Description of the interaction between Candida albicans and macrophages by mixed and quantitative proteome analysis without isolation 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Candida albicans is an opportunistic pathogen that causes fatal diseases in immunocompromised hosts. Host resistance against C. albicans relies on ingestion of the pathogen by macrophages. Analysis of the escaping behavior of C. albicans from macrophages is required to understand the onset of systemic candidiasis. In this study, native interactions of C. albicans with macrophages were investigated by proteome analysis using high efficiency of long monolithic silica capillary column. Using this system, we developed a method of “mixed and quantitative proteome analysis” in which C. albicans and macrophages were simultaneously analyzed by nanoLC–MS/MS without the need to isolate the two individual living cells. Two hundred twenty-seven proteins from C. albicans and five proteins from macrophages were identified as candidate interaction-specific molecules. C. albicans seemed to produce glucose through a β-oxidation pathway, a glyoxylate cycle, and gluconeogenesis for escape from macrophages. Up-regulation of stress-related and candidate pathogenic proteins in C. albicans indicated how C. albicans endured the harsh environment inside the macrophages. Down-regulation of apoptosis-associated protein NOA1- and chaperone HSPA1A-syntheses in macrophage indicated that C. albicans was able to escape from macrophages in part by suppressing the production of these macrophage proteins. Macrophage (dpeaa)DE-He213 Mixed proteome analysis (dpeaa)DE-He213 Quantitative proteome analysis (dpeaa)DE-He213 Apoptosis (dpeaa)DE-He213 Chaperone (dpeaa)DE-He213 Morisaka, Hironobu verfasserin aut Aoki, Wataru verfasserin aut Takeda, Yumiko verfasserin aut Shibasaki, Seiji verfasserin aut Kuroda, Kouichi verfasserin aut Ueda, Mitsuyoshi verfasserin aut Enthalten in AMB express Heidelberg : Springer, 2011 5(2015), 1 vom: 16. Juli (DE-627)665672926 (DE-600)2621432-5 2191-0855 nnns volume:5 year:2015 number:1 day:16 month:07 https://dx.doi.org/10.1186/s13568-015-0127-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 58.30 ASE AR 5 2015 1 16 07 |
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10.1186/s13568-015-0127-2 doi (DE-627)SPR031828817 (SPR)s13568-015-0127-2-e DE-627 ger DE-627 rakwb eng 570 ASE 58.30 bkl Kitahara, Nao verfasserin aut Description of the interaction between Candida albicans and macrophages by mixed and quantitative proteome analysis without isolation 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Candida albicans is an opportunistic pathogen that causes fatal diseases in immunocompromised hosts. Host resistance against C. albicans relies on ingestion of the pathogen by macrophages. Analysis of the escaping behavior of C. albicans from macrophages is required to understand the onset of systemic candidiasis. In this study, native interactions of C. albicans with macrophages were investigated by proteome analysis using high efficiency of long monolithic silica capillary column. Using this system, we developed a method of “mixed and quantitative proteome analysis” in which C. albicans and macrophages were simultaneously analyzed by nanoLC–MS/MS without the need to isolate the two individual living cells. Two hundred twenty-seven proteins from C. albicans and five proteins from macrophages were identified as candidate interaction-specific molecules. C. albicans seemed to produce glucose through a β-oxidation pathway, a glyoxylate cycle, and gluconeogenesis for escape from macrophages. Up-regulation of stress-related and candidate pathogenic proteins in C. albicans indicated how C. albicans endured the harsh environment inside the macrophages. Down-regulation of apoptosis-associated protein NOA1- and chaperone HSPA1A-syntheses in macrophage indicated that C. albicans was able to escape from macrophages in part by suppressing the production of these macrophage proteins. Macrophage (dpeaa)DE-He213 Mixed proteome analysis (dpeaa)DE-He213 Quantitative proteome analysis (dpeaa)DE-He213 Apoptosis (dpeaa)DE-He213 Chaperone (dpeaa)DE-He213 Morisaka, Hironobu verfasserin aut Aoki, Wataru verfasserin aut Takeda, Yumiko verfasserin aut Shibasaki, Seiji verfasserin aut Kuroda, Kouichi verfasserin aut Ueda, Mitsuyoshi verfasserin aut Enthalten in AMB express Heidelberg : Springer, 2011 5(2015), 1 vom: 16. Juli (DE-627)665672926 (DE-600)2621432-5 2191-0855 nnns volume:5 year:2015 number:1 day:16 month:07 https://dx.doi.org/10.1186/s13568-015-0127-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 58.30 ASE AR 5 2015 1 16 07 |
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10.1186/s13568-015-0127-2 doi (DE-627)SPR031828817 (SPR)s13568-015-0127-2-e DE-627 ger DE-627 rakwb eng 570 ASE 58.30 bkl Kitahara, Nao verfasserin aut Description of the interaction between Candida albicans and macrophages by mixed and quantitative proteome analysis without isolation 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Candida albicans is an opportunistic pathogen that causes fatal diseases in immunocompromised hosts. Host resistance against C. albicans relies on ingestion of the pathogen by macrophages. Analysis of the escaping behavior of C. albicans from macrophages is required to understand the onset of systemic candidiasis. In this study, native interactions of C. albicans with macrophages were investigated by proteome analysis using high efficiency of long monolithic silica capillary column. Using this system, we developed a method of “mixed and quantitative proteome analysis” in which C. albicans and macrophages were simultaneously analyzed by nanoLC–MS/MS without the need to isolate the two individual living cells. Two hundred twenty-seven proteins from C. albicans and five proteins from macrophages were identified as candidate interaction-specific molecules. C. albicans seemed to produce glucose through a β-oxidation pathway, a glyoxylate cycle, and gluconeogenesis for escape from macrophages. Up-regulation of stress-related and candidate pathogenic proteins in C. albicans indicated how C. albicans endured the harsh environment inside the macrophages. Down-regulation of apoptosis-associated protein NOA1- and chaperone HSPA1A-syntheses in macrophage indicated that C. albicans was able to escape from macrophages in part by suppressing the production of these macrophage proteins. Macrophage (dpeaa)DE-He213 Mixed proteome analysis (dpeaa)DE-He213 Quantitative proteome analysis (dpeaa)DE-He213 Apoptosis (dpeaa)DE-He213 Chaperone (dpeaa)DE-He213 Morisaka, Hironobu verfasserin aut Aoki, Wataru verfasserin aut Takeda, Yumiko verfasserin aut Shibasaki, Seiji verfasserin aut Kuroda, Kouichi verfasserin aut Ueda, Mitsuyoshi verfasserin aut Enthalten in AMB express Heidelberg : Springer, 2011 5(2015), 1 vom: 16. Juli (DE-627)665672926 (DE-600)2621432-5 2191-0855 nnns volume:5 year:2015 number:1 day:16 month:07 https://dx.doi.org/10.1186/s13568-015-0127-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 58.30 ASE AR 5 2015 1 16 07 |
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Kitahara, Nao @@aut@@ Morisaka, Hironobu @@aut@@ Aoki, Wataru @@aut@@ Takeda, Yumiko @@aut@@ Shibasaki, Seiji @@aut@@ Kuroda, Kouichi @@aut@@ Ueda, Mitsuyoshi @@aut@@ |
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Description of the interaction between Candida albicans and macrophages by mixed and quantitative proteome analysis without isolation |
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Abstract Candida albicans is an opportunistic pathogen that causes fatal diseases in immunocompromised hosts. Host resistance against C. albicans relies on ingestion of the pathogen by macrophages. Analysis of the escaping behavior of C. albicans from macrophages is required to understand the onset of systemic candidiasis. In this study, native interactions of C. albicans with macrophages were investigated by proteome analysis using high efficiency of long monolithic silica capillary column. Using this system, we developed a method of “mixed and quantitative proteome analysis” in which C. albicans and macrophages were simultaneously analyzed by nanoLC–MS/MS without the need to isolate the two individual living cells. Two hundred twenty-seven proteins from C. albicans and five proteins from macrophages were identified as candidate interaction-specific molecules. C. albicans seemed to produce glucose through a β-oxidation pathway, a glyoxylate cycle, and gluconeogenesis for escape from macrophages. Up-regulation of stress-related and candidate pathogenic proteins in C. albicans indicated how C. albicans endured the harsh environment inside the macrophages. Down-regulation of apoptosis-associated protein NOA1- and chaperone HSPA1A-syntheses in macrophage indicated that C. albicans was able to escape from macrophages in part by suppressing the production of these macrophage proteins. |
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Abstract Candida albicans is an opportunistic pathogen that causes fatal diseases in immunocompromised hosts. Host resistance against C. albicans relies on ingestion of the pathogen by macrophages. Analysis of the escaping behavior of C. albicans from macrophages is required to understand the onset of systemic candidiasis. In this study, native interactions of C. albicans with macrophages were investigated by proteome analysis using high efficiency of long monolithic silica capillary column. Using this system, we developed a method of “mixed and quantitative proteome analysis” in which C. albicans and macrophages were simultaneously analyzed by nanoLC–MS/MS without the need to isolate the two individual living cells. Two hundred twenty-seven proteins from C. albicans and five proteins from macrophages were identified as candidate interaction-specific molecules. C. albicans seemed to produce glucose through a β-oxidation pathway, a glyoxylate cycle, and gluconeogenesis for escape from macrophages. Up-regulation of stress-related and candidate pathogenic proteins in C. albicans indicated how C. albicans endured the harsh environment inside the macrophages. Down-regulation of apoptosis-associated protein NOA1- and chaperone HSPA1A-syntheses in macrophage indicated that C. albicans was able to escape from macrophages in part by suppressing the production of these macrophage proteins. |
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Abstract Candida albicans is an opportunistic pathogen that causes fatal diseases in immunocompromised hosts. Host resistance against C. albicans relies on ingestion of the pathogen by macrophages. Analysis of the escaping behavior of C. albicans from macrophages is required to understand the onset of systemic candidiasis. In this study, native interactions of C. albicans with macrophages were investigated by proteome analysis using high efficiency of long monolithic silica capillary column. Using this system, we developed a method of “mixed and quantitative proteome analysis” in which C. albicans and macrophages were simultaneously analyzed by nanoLC–MS/MS without the need to isolate the two individual living cells. Two hundred twenty-seven proteins from C. albicans and five proteins from macrophages were identified as candidate interaction-specific molecules. C. albicans seemed to produce glucose through a β-oxidation pathway, a glyoxylate cycle, and gluconeogenesis for escape from macrophages. Up-regulation of stress-related and candidate pathogenic proteins in C. albicans indicated how C. albicans endured the harsh environment inside the macrophages. Down-regulation of apoptosis-associated protein NOA1- and chaperone HSPA1A-syntheses in macrophage indicated that C. albicans was able to escape from macrophages in part by suppressing the production of these macrophage proteins. |
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