Osteosarcoma follow-up: chest X-ray or computed tomography?

Background In patients with relapsed osteosarcoma, the surgical excision of all metastases, defined as second complete remission (CR-2), is the factor that mainly influences post-relapse survival (PRS). Currently a validated follow-up policy for osteosarcoma is not available, both chest X-ray and co...
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Autor*in:	Paioli, Anna [verfasserIn] Rocca, Michele [verfasserIn] Cevolani, Luca [verfasserIn] Rimondi, Eugenio [verfasserIn] Vanel, Daniel [verfasserIn] Palmerini, Emanuela [verfasserIn] Cesari, Marilena [verfasserIn] Longhi, Alessandra [verfasserIn] Eraldo, Abate Massimo [verfasserIn] Marchesi, Emanuela [verfasserIn] Picci, Piero [verfasserIn] Ferrari, Stefano [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	Osteosarcoma Follow-up Chest X-ray Chest computed tomography

Übergeordnetes Werk:	Enthalten in: Clinical Sarcoma Research - London : BioMed Central, 2011, 7(2017), 1 vom: 14. Feb.
Übergeordnetes Werk:	volume:7 ; year:2017 ; number:1 ; day:14 ; month:02

Links:	Volltext

DOI / URN:	10.1186/s13569-017-0067-5

Katalog-ID:	SPR031839584

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520			\|a Background In patients with relapsed osteosarcoma, the surgical excision of all metastases, defined as second complete remission (CR-2), is the factor that mainly influences post-relapse survival (PRS). Currently a validated follow-up policy for osteosarcoma is not available, both chest X-ray and computed tomography (CT) are suggested for lung surveillance. The purpose of this study is to evaluate whether the type of imaging technique used for chest surveillance, chest X-ray or CT, influenced the rate of CR-2 and prognosis in patients with recurrent osteosarcoma. Methods Patients up to 40 years with extremity osteosarcoma enrolled in consecutive clinical trials and treated at the Rizzoli Institute from 1986 to 2009 were identified. Only patients who had lung metastases alone as first pattern of recurrence were considered for the analysis. The rate of CR-2, overall survival (OS) and PRS were the end-points of the study. Results The median follow-up was 47 months (1–300), 215 patients were eligible. Lung metastases were detected by chest X-ray in 100 (47%) patients, by CT in 112 (52%) and by symptoms in 3 (1%). CR-2 rate was 60% for patients followed by X-rays and 88% for those followed by CT (p < .0001). 5-year PRS was 30% (95% CI 21–39) in the X-ray group and 49% (95% CI 39–59) in the CT group (p = .0004). 5-year OS was 35% (95% CI 26–44) in the X-ray group and 60% (95% CI 51–70) in the CT group (p = .004). Conclusions A follow-up strategy with chest CT leads to a higher rate of CR-2 and significantly improves PRS and OS in osteosarcoma, compared to chest X-ray.
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allfields	10.1186/s13569-017-0067-5 doi (DE-627)SPR031839584 (SPR)s13569-017-0067-5-e DE-627 ger DE-627 rakwb eng 610 ASE Paioli, Anna verfasserin aut Osteosarcoma follow-up: chest X-ray or computed tomography? 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background In patients with relapsed osteosarcoma, the surgical excision of all metastases, defined as second complete remission (CR-2), is the factor that mainly influences post-relapse survival (PRS). Currently a validated follow-up policy for osteosarcoma is not available, both chest X-ray and computed tomography (CT) are suggested for lung surveillance. The purpose of this study is to evaluate whether the type of imaging technique used for chest surveillance, chest X-ray or CT, influenced the rate of CR-2 and prognosis in patients with recurrent osteosarcoma. Methods Patients up to 40 years with extremity osteosarcoma enrolled in consecutive clinical trials and treated at the Rizzoli Institute from 1986 to 2009 were identified. Only patients who had lung metastases alone as first pattern of recurrence were considered for the analysis. The rate of CR-2, overall survival (OS) and PRS were the end-points of the study. Results The median follow-up was 47 months (1–300), 215 patients were eligible. Lung metastases were detected by chest X-ray in 100 (47%) patients, by CT in 112 (52%) and by symptoms in 3 (1%). CR-2 rate was 60% for patients followed by X-rays and 88% for those followed by CT (p < .0001). 5-year PRS was 30% (95% CI 21–39) in the X-ray group and 49% (95% CI 39–59) in the CT group (p = .0004). 5-year OS was 35% (95% CI 26–44) in the X-ray group and 60% (95% CI 51–70) in the CT group (p = .004). Conclusions A follow-up strategy with chest CT leads to a higher rate of CR-2 and significantly improves PRS and OS in osteosarcoma, compared to chest X-ray. Osteosarcoma (dpeaa)DE-He213 Follow-up (dpeaa)DE-He213 Chest X-ray (dpeaa)DE-He213 Chest computed tomography (dpeaa)DE-He213 Rocca, Michele verfasserin aut Cevolani, Luca verfasserin aut Rimondi, Eugenio verfasserin aut Vanel, Daniel verfasserin aut Palmerini, Emanuela verfasserin aut Cesari, Marilena verfasserin aut Longhi, Alessandra verfasserin aut Eraldo, Abate Massimo verfasserin aut Marchesi, Emanuela verfasserin aut Picci, Piero verfasserin aut Ferrari, Stefano verfasserin aut Enthalten in Clinical Sarcoma Research London : BioMed Central, 2011 7(2017), 1 vom: 14. Feb. (DE-627)666217785 (DE-600)2623217-0 2045-3329 nnns volume:7 year:2017 number:1 day:14 month:02 https://dx.doi.org/10.1186/s13569-017-0067-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2017 1 14 02
spelling	10.1186/s13569-017-0067-5 doi (DE-627)SPR031839584 (SPR)s13569-017-0067-5-e DE-627 ger DE-627 rakwb eng 610 ASE Paioli, Anna verfasserin aut Osteosarcoma follow-up: chest X-ray or computed tomography? 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background In patients with relapsed osteosarcoma, the surgical excision of all metastases, defined as second complete remission (CR-2), is the factor that mainly influences post-relapse survival (PRS). Currently a validated follow-up policy for osteosarcoma is not available, both chest X-ray and computed tomography (CT) are suggested for lung surveillance. The purpose of this study is to evaluate whether the type of imaging technique used for chest surveillance, chest X-ray or CT, influenced the rate of CR-2 and prognosis in patients with recurrent osteosarcoma. Methods Patients up to 40 years with extremity osteosarcoma enrolled in consecutive clinical trials and treated at the Rizzoli Institute from 1986 to 2009 were identified. Only patients who had lung metastases alone as first pattern of recurrence were considered for the analysis. The rate of CR-2, overall survival (OS) and PRS were the end-points of the study. Results The median follow-up was 47 months (1–300), 215 patients were eligible. Lung metastases were detected by chest X-ray in 100 (47%) patients, by CT in 112 (52%) and by symptoms in 3 (1%). CR-2 rate was 60% for patients followed by X-rays and 88% for those followed by CT (p < .0001). 5-year PRS was 30% (95% CI 21–39) in the X-ray group and 49% (95% CI 39–59) in the CT group (p = .0004). 5-year OS was 35% (95% CI 26–44) in the X-ray group and 60% (95% CI 51–70) in the CT group (p = .004). Conclusions A follow-up strategy with chest CT leads to a higher rate of CR-2 and significantly improves PRS and OS in osteosarcoma, compared to chest X-ray. Osteosarcoma (dpeaa)DE-He213 Follow-up (dpeaa)DE-He213 Chest X-ray (dpeaa)DE-He213 Chest computed tomography (dpeaa)DE-He213 Rocca, Michele verfasserin aut Cevolani, Luca verfasserin aut Rimondi, Eugenio verfasserin aut Vanel, Daniel verfasserin aut Palmerini, Emanuela verfasserin aut Cesari, Marilena verfasserin aut Longhi, Alessandra verfasserin aut Eraldo, Abate Massimo verfasserin aut Marchesi, Emanuela verfasserin aut Picci, Piero verfasserin aut Ferrari, Stefano verfasserin aut Enthalten in Clinical Sarcoma Research London : BioMed Central, 2011 7(2017), 1 vom: 14. Feb. (DE-627)666217785 (DE-600)2623217-0 2045-3329 nnns volume:7 year:2017 number:1 day:14 month:02 https://dx.doi.org/10.1186/s13569-017-0067-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2017 1 14 02
allfields_unstemmed	10.1186/s13569-017-0067-5 doi (DE-627)SPR031839584 (SPR)s13569-017-0067-5-e DE-627 ger DE-627 rakwb eng 610 ASE Paioli, Anna verfasserin aut Osteosarcoma follow-up: chest X-ray or computed tomography? 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background In patients with relapsed osteosarcoma, the surgical excision of all metastases, defined as second complete remission (CR-2), is the factor that mainly influences post-relapse survival (PRS). Currently a validated follow-up policy for osteosarcoma is not available, both chest X-ray and computed tomography (CT) are suggested for lung surveillance. The purpose of this study is to evaluate whether the type of imaging technique used for chest surveillance, chest X-ray or CT, influenced the rate of CR-2 and prognosis in patients with recurrent osteosarcoma. Methods Patients up to 40 years with extremity osteosarcoma enrolled in consecutive clinical trials and treated at the Rizzoli Institute from 1986 to 2009 were identified. Only patients who had lung metastases alone as first pattern of recurrence were considered for the analysis. The rate of CR-2, overall survival (OS) and PRS were the end-points of the study. Results The median follow-up was 47 months (1–300), 215 patients were eligible. Lung metastases were detected by chest X-ray in 100 (47%) patients, by CT in 112 (52%) and by symptoms in 3 (1%). CR-2 rate was 60% for patients followed by X-rays and 88% for those followed by CT (p < .0001). 5-year PRS was 30% (95% CI 21–39) in the X-ray group and 49% (95% CI 39–59) in the CT group (p = .0004). 5-year OS was 35% (95% CI 26–44) in the X-ray group and 60% (95% CI 51–70) in the CT group (p = .004). Conclusions A follow-up strategy with chest CT leads to a higher rate of CR-2 and significantly improves PRS and OS in osteosarcoma, compared to chest X-ray. Osteosarcoma (dpeaa)DE-He213 Follow-up (dpeaa)DE-He213 Chest X-ray (dpeaa)DE-He213 Chest computed tomography (dpeaa)DE-He213 Rocca, Michele verfasserin aut Cevolani, Luca verfasserin aut Rimondi, Eugenio verfasserin aut Vanel, Daniel verfasserin aut Palmerini, Emanuela verfasserin aut Cesari, Marilena verfasserin aut Longhi, Alessandra verfasserin aut Eraldo, Abate Massimo verfasserin aut Marchesi, Emanuela verfasserin aut Picci, Piero verfasserin aut Ferrari, Stefano verfasserin aut Enthalten in Clinical Sarcoma Research London : BioMed Central, 2011 7(2017), 1 vom: 14. Feb. (DE-627)666217785 (DE-600)2623217-0 2045-3329 nnns volume:7 year:2017 number:1 day:14 month:02 https://dx.doi.org/10.1186/s13569-017-0067-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2017 1 14 02
allfieldsGer	10.1186/s13569-017-0067-5 doi (DE-627)SPR031839584 (SPR)s13569-017-0067-5-e DE-627 ger DE-627 rakwb eng 610 ASE Paioli, Anna verfasserin aut Osteosarcoma follow-up: chest X-ray or computed tomography? 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background In patients with relapsed osteosarcoma, the surgical excision of all metastases, defined as second complete remission (CR-2), is the factor that mainly influences post-relapse survival (PRS). Currently a validated follow-up policy for osteosarcoma is not available, both chest X-ray and computed tomography (CT) are suggested for lung surveillance. The purpose of this study is to evaluate whether the type of imaging technique used for chest surveillance, chest X-ray or CT, influenced the rate of CR-2 and prognosis in patients with recurrent osteosarcoma. Methods Patients up to 40 years with extremity osteosarcoma enrolled in consecutive clinical trials and treated at the Rizzoli Institute from 1986 to 2009 were identified. Only patients who had lung metastases alone as first pattern of recurrence were considered for the analysis. The rate of CR-2, overall survival (OS) and PRS were the end-points of the study. Results The median follow-up was 47 months (1–300), 215 patients were eligible. Lung metastases were detected by chest X-ray in 100 (47%) patients, by CT in 112 (52%) and by symptoms in 3 (1%). CR-2 rate was 60% for patients followed by X-rays and 88% for those followed by CT (p < .0001). 5-year PRS was 30% (95% CI 21–39) in the X-ray group and 49% (95% CI 39–59) in the CT group (p = .0004). 5-year OS was 35% (95% CI 26–44) in the X-ray group and 60% (95% CI 51–70) in the CT group (p = .004). Conclusions A follow-up strategy with chest CT leads to a higher rate of CR-2 and significantly improves PRS and OS in osteosarcoma, compared to chest X-ray. Osteosarcoma (dpeaa)DE-He213 Follow-up (dpeaa)DE-He213 Chest X-ray (dpeaa)DE-He213 Chest computed tomography (dpeaa)DE-He213 Rocca, Michele verfasserin aut Cevolani, Luca verfasserin aut Rimondi, Eugenio verfasserin aut Vanel, Daniel verfasserin aut Palmerini, Emanuela verfasserin aut Cesari, Marilena verfasserin aut Longhi, Alessandra verfasserin aut Eraldo, Abate Massimo verfasserin aut Marchesi, Emanuela verfasserin aut Picci, Piero verfasserin aut Ferrari, Stefano verfasserin aut Enthalten in Clinical Sarcoma Research London : BioMed Central, 2011 7(2017), 1 vom: 14. Feb. (DE-627)666217785 (DE-600)2623217-0 2045-3329 nnns volume:7 year:2017 number:1 day:14 month:02 https://dx.doi.org/10.1186/s13569-017-0067-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2017 1 14 02
allfieldsSound	10.1186/s13569-017-0067-5 doi (DE-627)SPR031839584 (SPR)s13569-017-0067-5-e DE-627 ger DE-627 rakwb eng 610 ASE Paioli, Anna verfasserin aut Osteosarcoma follow-up: chest X-ray or computed tomography? 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background In patients with relapsed osteosarcoma, the surgical excision of all metastases, defined as second complete remission (CR-2), is the factor that mainly influences post-relapse survival (PRS). Currently a validated follow-up policy for osteosarcoma is not available, both chest X-ray and computed tomography (CT) are suggested for lung surveillance. The purpose of this study is to evaluate whether the type of imaging technique used for chest surveillance, chest X-ray or CT, influenced the rate of CR-2 and prognosis in patients with recurrent osteosarcoma. Methods Patients up to 40 years with extremity osteosarcoma enrolled in consecutive clinical trials and treated at the Rizzoli Institute from 1986 to 2009 were identified. Only patients who had lung metastases alone as first pattern of recurrence were considered for the analysis. The rate of CR-2, overall survival (OS) and PRS were the end-points of the study. Results The median follow-up was 47 months (1–300), 215 patients were eligible. Lung metastases were detected by chest X-ray in 100 (47%) patients, by CT in 112 (52%) and by symptoms in 3 (1%). CR-2 rate was 60% for patients followed by X-rays and 88% for those followed by CT (p < .0001). 5-year PRS was 30% (95% CI 21–39) in the X-ray group and 49% (95% CI 39–59) in the CT group (p = .0004). 5-year OS was 35% (95% CI 26–44) in the X-ray group and 60% (95% CI 51–70) in the CT group (p = .004). Conclusions A follow-up strategy with chest CT leads to a higher rate of CR-2 and significantly improves PRS and OS in osteosarcoma, compared to chest X-ray. Osteosarcoma (dpeaa)DE-He213 Follow-up (dpeaa)DE-He213 Chest X-ray (dpeaa)DE-He213 Chest computed tomography (dpeaa)DE-He213 Rocca, Michele verfasserin aut Cevolani, Luca verfasserin aut Rimondi, Eugenio verfasserin aut Vanel, Daniel verfasserin aut Palmerini, Emanuela verfasserin aut Cesari, Marilena verfasserin aut Longhi, Alessandra verfasserin aut Eraldo, Abate Massimo verfasserin aut Marchesi, Emanuela verfasserin aut Picci, Piero verfasserin aut Ferrari, Stefano verfasserin aut Enthalten in Clinical Sarcoma Research London : BioMed Central, 2011 7(2017), 1 vom: 14. Feb. (DE-627)666217785 (DE-600)2623217-0 2045-3329 nnns volume:7 year:2017 number:1 day:14 month:02 https://dx.doi.org/10.1186/s13569-017-0067-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2017 1 14 02
language	English
source	Enthalten in Clinical Sarcoma Research 7(2017), 1 vom: 14. Feb. volume:7 year:2017 number:1 day:14 month:02
sourceStr	Enthalten in Clinical Sarcoma Research 7(2017), 1 vom: 14. Feb. volume:7 year:2017 number:1 day:14 month:02
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Osteosarcoma Follow-up Chest X-ray Chest computed tomography
dewey-raw	610
isfreeaccess_bool	true
container_title	Clinical Sarcoma Research
authorswithroles_txt_mv	Paioli, Anna @@aut@@ Rocca, Michele @@aut@@ Cevolani, Luca @@aut@@ Rimondi, Eugenio @@aut@@ Vanel, Daniel @@aut@@ Palmerini, Emanuela @@aut@@ Cesari, Marilena @@aut@@ Longhi, Alessandra @@aut@@ Eraldo, Abate Massimo @@aut@@ Marchesi, Emanuela @@aut@@ Picci, Piero @@aut@@ Ferrari, Stefano @@aut@@
publishDateDaySort_date	2017-02-14T00:00:00Z
hierarchy_top_id	666217785
dewey-sort	3610
id	SPR031839584
language_de	englisch
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CR-2 rate was 60% for patients followed by X-rays and 88% for those followed by CT (p < .0001). 5-year PRS was 30% (95% CI 21–39) in the X-ray group and 49% (95% CI 39–59) in the CT group (p = .0004). 5-year OS was 35% (95% CI 26–44) in the X-ray group and 60% (95% CI 51–70) in the CT group (p = .004). 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author	Paioli, Anna
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topic_title	610 ASE Osteosarcoma follow-up: chest X-ray or computed tomography? Osteosarcoma (dpeaa)DE-He213 Follow-up (dpeaa)DE-He213 Chest X-ray (dpeaa)DE-He213 Chest computed tomography (dpeaa)DE-He213
topic	ddc 610 misc Osteosarcoma misc Follow-up misc Chest X-ray misc Chest computed tomography
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title	Osteosarcoma follow-up: chest X-ray or computed tomography?
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title_full	Osteosarcoma follow-up: chest X-ray or computed tomography?
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author_browse	Paioli, Anna Rocca, Michele Cevolani, Luca Rimondi, Eugenio Vanel, Daniel Palmerini, Emanuela Cesari, Marilena Longhi, Alessandra Eraldo, Abate Massimo Marchesi, Emanuela Picci, Piero Ferrari, Stefano
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title_sort	osteosarcoma follow-up: chest x-ray or computed tomography?
title_auth	Osteosarcoma follow-up: chest X-ray or computed tomography?
abstract	Background In patients with relapsed osteosarcoma, the surgical excision of all metastases, defined as second complete remission (CR-2), is the factor that mainly influences post-relapse survival (PRS). Currently a validated follow-up policy for osteosarcoma is not available, both chest X-ray and computed tomography (CT) are suggested for lung surveillance. The purpose of this study is to evaluate whether the type of imaging technique used for chest surveillance, chest X-ray or CT, influenced the rate of CR-2 and prognosis in patients with recurrent osteosarcoma. Methods Patients up to 40 years with extremity osteosarcoma enrolled in consecutive clinical trials and treated at the Rizzoli Institute from 1986 to 2009 were identified. Only patients who had lung metastases alone as first pattern of recurrence were considered for the analysis. The rate of CR-2, overall survival (OS) and PRS were the end-points of the study. Results The median follow-up was 47 months (1–300), 215 patients were eligible. Lung metastases were detected by chest X-ray in 100 (47%) patients, by CT in 112 (52%) and by symptoms in 3 (1%). CR-2 rate was 60% for patients followed by X-rays and 88% for those followed by CT (p < .0001). 5-year PRS was 30% (95% CI 21–39) in the X-ray group and 49% (95% CI 39–59) in the CT group (p = .0004). 5-year OS was 35% (95% CI 26–44) in the X-ray group and 60% (95% CI 51–70) in the CT group (p = .004). Conclusions A follow-up strategy with chest CT leads to a higher rate of CR-2 and significantly improves PRS and OS in osteosarcoma, compared to chest X-ray.
abstractGer	Background In patients with relapsed osteosarcoma, the surgical excision of all metastases, defined as second complete remission (CR-2), is the factor that mainly influences post-relapse survival (PRS). Currently a validated follow-up policy for osteosarcoma is not available, both chest X-ray and computed tomography (CT) are suggested for lung surveillance. The purpose of this study is to evaluate whether the type of imaging technique used for chest surveillance, chest X-ray or CT, influenced the rate of CR-2 and prognosis in patients with recurrent osteosarcoma. Methods Patients up to 40 years with extremity osteosarcoma enrolled in consecutive clinical trials and treated at the Rizzoli Institute from 1986 to 2009 were identified. Only patients who had lung metastases alone as first pattern of recurrence were considered for the analysis. The rate of CR-2, overall survival (OS) and PRS were the end-points of the study. Results The median follow-up was 47 months (1–300), 215 patients were eligible. Lung metastases were detected by chest X-ray in 100 (47%) patients, by CT in 112 (52%) and by symptoms in 3 (1%). CR-2 rate was 60% for patients followed by X-rays and 88% for those followed by CT (p < .0001). 5-year PRS was 30% (95% CI 21–39) in the X-ray group and 49% (95% CI 39–59) in the CT group (p = .0004). 5-year OS was 35% (95% CI 26–44) in the X-ray group and 60% (95% CI 51–70) in the CT group (p = .004). Conclusions A follow-up strategy with chest CT leads to a higher rate of CR-2 and significantly improves PRS and OS in osteosarcoma, compared to chest X-ray.
abstract_unstemmed	Background In patients with relapsed osteosarcoma, the surgical excision of all metastases, defined as second complete remission (CR-2), is the factor that mainly influences post-relapse survival (PRS). Currently a validated follow-up policy for osteosarcoma is not available, both chest X-ray and computed tomography (CT) are suggested for lung surveillance. The purpose of this study is to evaluate whether the type of imaging technique used for chest surveillance, chest X-ray or CT, influenced the rate of CR-2 and prognosis in patients with recurrent osteosarcoma. Methods Patients up to 40 years with extremity osteosarcoma enrolled in consecutive clinical trials and treated at the Rizzoli Institute from 1986 to 2009 were identified. Only patients who had lung metastases alone as first pattern of recurrence were considered for the analysis. The rate of CR-2, overall survival (OS) and PRS were the end-points of the study. Results The median follow-up was 47 months (1–300), 215 patients were eligible. Lung metastases were detected by chest X-ray in 100 (47%) patients, by CT in 112 (52%) and by symptoms in 3 (1%). CR-2 rate was 60% for patients followed by X-rays and 88% for those followed by CT (p < .0001). 5-year PRS was 30% (95% CI 21–39) in the X-ray group and 49% (95% CI 39–59) in the CT group (p = .0004). 5-year OS was 35% (95% CI 26–44) in the X-ray group and 60% (95% CI 51–70) in the CT group (p = .004). Conclusions A follow-up strategy with chest CT leads to a higher rate of CR-2 and significantly improves PRS and OS in osteosarcoma, compared to chest X-ray.
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title_short	Osteosarcoma follow-up: chest X-ray or computed tomography?
url	https://dx.doi.org/10.1186/s13569-017-0067-5
remote_bool	true
author2	Rocca, Michele Cevolani, Luca Rimondi, Eugenio Vanel, Daniel Palmerini, Emanuela Cesari, Marilena Longhi, Alessandra Eraldo, Abate Massimo Marchesi, Emanuela Picci, Piero Ferrari, Stefano
author2Str	Rocca, Michele Cevolani, Luca Rimondi, Eugenio Vanel, Daniel Palmerini, Emanuela Cesari, Marilena Longhi, Alessandra Eraldo, Abate Massimo Marchesi, Emanuela Picci, Piero Ferrari, Stefano
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up_date	2024-07-04T01:28:15.838Z
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