Combination of EZH2 inhibitor and BET inhibitor for treatment of diffuse intrinsic pontine glioma

Background Diffuse intrinsic pontine glioma is an infiltrative, often high-grade glioma of the brainstem that is not amenable to surgical resection. The current treatment of DIPG by radiation therapy showed dramatically improvement of patient’s condition, however, the tumor recurs rapidly. More and...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Zhang, Yaqin [verfasserIn] Dong, Weijie [verfasserIn] Zhu, Junying [verfasserIn] Wang, Lizhu [verfasserIn] Wu, Xinjian [verfasserIn] Shan, Hong [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	DIPG EZH2 inhibitor BET inhibitor Epigenetics Tumor therapy

Übergeordnetes Werk:	Enthalten in: Cell & bioscience - London : BioMed Central, 2011, 7(2017), 1 vom: 30. Okt.
Übergeordnetes Werk:	volume:7 ; year:2017 ; number:1 ; day:30 ; month:10

Links:	Volltext

DOI / URN:	10.1186/s13578-017-0184-0

Katalog-ID:	SPR031854834

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520			\|a Background Diffuse intrinsic pontine glioma is an infiltrative, often high-grade glioma of the brainstem that is not amenable to surgical resection. The current treatment of DIPG by radiation therapy showed dramatically improvement of patient’s condition, however, the tumor recurs rapidly. More and more studies are focused on the genetic and epigenetic drivers of DIPGs, which may provide more and more novel therapy target for DIPG. EZH2 has been proved to be a potential therapeutic target for H3K27M-mutant pediatric gliomas recently. Meanwhile, BET family protein is a hot target in many different types of cancers, including DIPG. In this study, we performed the treatment of both EZH2 and BET inhibitor for DIPG cells. Results The combination of these two inhibitors exhibited better inhibition of the tumor growth both in vitro and in vivo compared to use the inhibitor individually. This inhibition was performed by blocking the proliferation and promoting the cell apoptosis. Meanwhile, combination treatment of these two inhibitors would also affect the epigenetic markers which were abnormal in the tumors of the certain set of genes. Conclusion Thus we provided a novel therapy strategy for clinical treatment of DIPG.
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allfields	10.1186/s13578-017-0184-0 doi (DE-627)SPR031854834 (SPR)s13578-017-0184-0-e DE-627 ger DE-627 rakwb eng 050 ASE Zhang, Yaqin verfasserin aut Combination of EZH2 inhibitor and BET inhibitor for treatment of diffuse intrinsic pontine glioma 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Diffuse intrinsic pontine glioma is an infiltrative, often high-grade glioma of the brainstem that is not amenable to surgical resection. The current treatment of DIPG by radiation therapy showed dramatically improvement of patient’s condition, however, the tumor recurs rapidly. More and more studies are focused on the genetic and epigenetic drivers of DIPGs, which may provide more and more novel therapy target for DIPG. EZH2 has been proved to be a potential therapeutic target for H3K27M-mutant pediatric gliomas recently. Meanwhile, BET family protein is a hot target in many different types of cancers, including DIPG. In this study, we performed the treatment of both EZH2 and BET inhibitor for DIPG cells. Results The combination of these two inhibitors exhibited better inhibition of the tumor growth both in vitro and in vivo compared to use the inhibitor individually. This inhibition was performed by blocking the proliferation and promoting the cell apoptosis. Meanwhile, combination treatment of these two inhibitors would also affect the epigenetic markers which were abnormal in the tumors of the certain set of genes. Conclusion Thus we provided a novel therapy strategy for clinical treatment of DIPG. DIPG (dpeaa)DE-He213 EZH2 inhibitor (dpeaa)DE-He213 BET inhibitor (dpeaa)DE-He213 Epigenetics (dpeaa)DE-He213 Tumor therapy (dpeaa)DE-He213 Dong, Weijie verfasserin aut Zhu, Junying verfasserin aut Wang, Lizhu verfasserin aut Wu, Xinjian verfasserin aut Shan, Hong verfasserin aut Enthalten in Cell & bioscience London : BioMed Central, 2011 7(2017), 1 vom: 30. Okt. (DE-627)646079387 (DE-600)2593367-X 2045-3701 nnns volume:7 year:2017 number:1 day:30 month:10 https://dx.doi.org/10.1186/s13578-017-0184-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2017 1 30 10
spelling	10.1186/s13578-017-0184-0 doi (DE-627)SPR031854834 (SPR)s13578-017-0184-0-e DE-627 ger DE-627 rakwb eng 050 ASE Zhang, Yaqin verfasserin aut Combination of EZH2 inhibitor and BET inhibitor for treatment of diffuse intrinsic pontine glioma 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Diffuse intrinsic pontine glioma is an infiltrative, often high-grade glioma of the brainstem that is not amenable to surgical resection. The current treatment of DIPG by radiation therapy showed dramatically improvement of patient’s condition, however, the tumor recurs rapidly. More and more studies are focused on the genetic and epigenetic drivers of DIPGs, which may provide more and more novel therapy target for DIPG. EZH2 has been proved to be a potential therapeutic target for H3K27M-mutant pediatric gliomas recently. Meanwhile, BET family protein is a hot target in many different types of cancers, including DIPG. In this study, we performed the treatment of both EZH2 and BET inhibitor for DIPG cells. Results The combination of these two inhibitors exhibited better inhibition of the tumor growth both in vitro and in vivo compared to use the inhibitor individually. This inhibition was performed by blocking the proliferation and promoting the cell apoptosis. Meanwhile, combination treatment of these two inhibitors would also affect the epigenetic markers which were abnormal in the tumors of the certain set of genes. Conclusion Thus we provided a novel therapy strategy for clinical treatment of DIPG. DIPG (dpeaa)DE-He213 EZH2 inhibitor (dpeaa)DE-He213 BET inhibitor (dpeaa)DE-He213 Epigenetics (dpeaa)DE-He213 Tumor therapy (dpeaa)DE-He213 Dong, Weijie verfasserin aut Zhu, Junying verfasserin aut Wang, Lizhu verfasserin aut Wu, Xinjian verfasserin aut Shan, Hong verfasserin aut Enthalten in Cell & bioscience London : BioMed Central, 2011 7(2017), 1 vom: 30. Okt. (DE-627)646079387 (DE-600)2593367-X 2045-3701 nnns volume:7 year:2017 number:1 day:30 month:10 https://dx.doi.org/10.1186/s13578-017-0184-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2017 1 30 10
allfields_unstemmed	10.1186/s13578-017-0184-0 doi (DE-627)SPR031854834 (SPR)s13578-017-0184-0-e DE-627 ger DE-627 rakwb eng 050 ASE Zhang, Yaqin verfasserin aut Combination of EZH2 inhibitor and BET inhibitor for treatment of diffuse intrinsic pontine glioma 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Diffuse intrinsic pontine glioma is an infiltrative, often high-grade glioma of the brainstem that is not amenable to surgical resection. The current treatment of DIPG by radiation therapy showed dramatically improvement of patient’s condition, however, the tumor recurs rapidly. More and more studies are focused on the genetic and epigenetic drivers of DIPGs, which may provide more and more novel therapy target for DIPG. EZH2 has been proved to be a potential therapeutic target for H3K27M-mutant pediatric gliomas recently. Meanwhile, BET family protein is a hot target in many different types of cancers, including DIPG. In this study, we performed the treatment of both EZH2 and BET inhibitor for DIPG cells. Results The combination of these two inhibitors exhibited better inhibition of the tumor growth both in vitro and in vivo compared to use the inhibitor individually. This inhibition was performed by blocking the proliferation and promoting the cell apoptosis. Meanwhile, combination treatment of these two inhibitors would also affect the epigenetic markers which were abnormal in the tumors of the certain set of genes. Conclusion Thus we provided a novel therapy strategy for clinical treatment of DIPG. DIPG (dpeaa)DE-He213 EZH2 inhibitor (dpeaa)DE-He213 BET inhibitor (dpeaa)DE-He213 Epigenetics (dpeaa)DE-He213 Tumor therapy (dpeaa)DE-He213 Dong, Weijie verfasserin aut Zhu, Junying verfasserin aut Wang, Lizhu verfasserin aut Wu, Xinjian verfasserin aut Shan, Hong verfasserin aut Enthalten in Cell & bioscience London : BioMed Central, 2011 7(2017), 1 vom: 30. Okt. (DE-627)646079387 (DE-600)2593367-X 2045-3701 nnns volume:7 year:2017 number:1 day:30 month:10 https://dx.doi.org/10.1186/s13578-017-0184-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2017 1 30 10
allfieldsGer	10.1186/s13578-017-0184-0 doi (DE-627)SPR031854834 (SPR)s13578-017-0184-0-e DE-627 ger DE-627 rakwb eng 050 ASE Zhang, Yaqin verfasserin aut Combination of EZH2 inhibitor and BET inhibitor for treatment of diffuse intrinsic pontine glioma 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Diffuse intrinsic pontine glioma is an infiltrative, often high-grade glioma of the brainstem that is not amenable to surgical resection. The current treatment of DIPG by radiation therapy showed dramatically improvement of patient’s condition, however, the tumor recurs rapidly. More and more studies are focused on the genetic and epigenetic drivers of DIPGs, which may provide more and more novel therapy target for DIPG. EZH2 has been proved to be a potential therapeutic target for H3K27M-mutant pediatric gliomas recently. Meanwhile, BET family protein is a hot target in many different types of cancers, including DIPG. In this study, we performed the treatment of both EZH2 and BET inhibitor for DIPG cells. Results The combination of these two inhibitors exhibited better inhibition of the tumor growth both in vitro and in vivo compared to use the inhibitor individually. This inhibition was performed by blocking the proliferation and promoting the cell apoptosis. Meanwhile, combination treatment of these two inhibitors would also affect the epigenetic markers which were abnormal in the tumors of the certain set of genes. Conclusion Thus we provided a novel therapy strategy for clinical treatment of DIPG. DIPG (dpeaa)DE-He213 EZH2 inhibitor (dpeaa)DE-He213 BET inhibitor (dpeaa)DE-He213 Epigenetics (dpeaa)DE-He213 Tumor therapy (dpeaa)DE-He213 Dong, Weijie verfasserin aut Zhu, Junying verfasserin aut Wang, Lizhu verfasserin aut Wu, Xinjian verfasserin aut Shan, Hong verfasserin aut Enthalten in Cell & bioscience London : BioMed Central, 2011 7(2017), 1 vom: 30. Okt. (DE-627)646079387 (DE-600)2593367-X 2045-3701 nnns volume:7 year:2017 number:1 day:30 month:10 https://dx.doi.org/10.1186/s13578-017-0184-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2017 1 30 10
allfieldsSound	10.1186/s13578-017-0184-0 doi (DE-627)SPR031854834 (SPR)s13578-017-0184-0-e DE-627 ger DE-627 rakwb eng 050 ASE Zhang, Yaqin verfasserin aut Combination of EZH2 inhibitor and BET inhibitor for treatment of diffuse intrinsic pontine glioma 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Diffuse intrinsic pontine glioma is an infiltrative, often high-grade glioma of the brainstem that is not amenable to surgical resection. The current treatment of DIPG by radiation therapy showed dramatically improvement of patient’s condition, however, the tumor recurs rapidly. More and more studies are focused on the genetic and epigenetic drivers of DIPGs, which may provide more and more novel therapy target for DIPG. EZH2 has been proved to be a potential therapeutic target for H3K27M-mutant pediatric gliomas recently. Meanwhile, BET family protein is a hot target in many different types of cancers, including DIPG. In this study, we performed the treatment of both EZH2 and BET inhibitor for DIPG cells. Results The combination of these two inhibitors exhibited better inhibition of the tumor growth both in vitro and in vivo compared to use the inhibitor individually. This inhibition was performed by blocking the proliferation and promoting the cell apoptosis. Meanwhile, combination treatment of these two inhibitors would also affect the epigenetic markers which were abnormal in the tumors of the certain set of genes. Conclusion Thus we provided a novel therapy strategy for clinical treatment of DIPG. DIPG (dpeaa)DE-He213 EZH2 inhibitor (dpeaa)DE-He213 BET inhibitor (dpeaa)DE-He213 Epigenetics (dpeaa)DE-He213 Tumor therapy (dpeaa)DE-He213 Dong, Weijie verfasserin aut Zhu, Junying verfasserin aut Wang, Lizhu verfasserin aut Wu, Xinjian verfasserin aut Shan, Hong verfasserin aut Enthalten in Cell & bioscience London : BioMed Central, 2011 7(2017), 1 vom: 30. Okt. (DE-627)646079387 (DE-600)2593367-X 2045-3701 nnns volume:7 year:2017 number:1 day:30 month:10 https://dx.doi.org/10.1186/s13578-017-0184-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2017 1 30 10
language	English
source	Enthalten in Cell & bioscience 7(2017), 1 vom: 30. Okt. volume:7 year:2017 number:1 day:30 month:10
sourceStr	Enthalten in Cell & bioscience 7(2017), 1 vom: 30. Okt. volume:7 year:2017 number:1 day:30 month:10
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	DIPG EZH2 inhibitor BET inhibitor Epigenetics Tumor therapy
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container_title	Cell & bioscience
authorswithroles_txt_mv	Zhang, Yaqin @@aut@@ Dong, Weijie @@aut@@ Zhu, Junying @@aut@@ Wang, Lizhu @@aut@@ Wu, Xinjian @@aut@@ Shan, Hong @@aut@@
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The current treatment of DIPG by radiation therapy showed dramatically improvement of patient’s condition, however, the tumor recurs rapidly. More and more studies are focused on the genetic and epigenetic drivers of DIPGs, which may provide more and more novel therapy target for DIPG. EZH2 has been proved to be a potential therapeutic target for H3K27M-mutant pediatric gliomas recently. Meanwhile, BET family protein is a hot target in many different types of cancers, including DIPG. In this study, we performed the treatment of both EZH2 and BET inhibitor for DIPG cells. Results The combination of these two inhibitors exhibited better inhibition of the tumor growth both in vitro and in vivo compared to use the inhibitor individually. This inhibition was performed by blocking the proliferation and promoting the cell apoptosis. Meanwhile, combination treatment of these two inhibitors would also affect the epigenetic markers which were abnormal in the tumors of the certain set of genes. 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author	Zhang, Yaqin
spellingShingle	Zhang, Yaqin ddc 050 misc DIPG misc EZH2 inhibitor misc BET inhibitor misc Epigenetics misc Tumor therapy Combination of EZH2 inhibitor and BET inhibitor for treatment of diffuse intrinsic pontine glioma
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topic_title	050 ASE Combination of EZH2 inhibitor and BET inhibitor for treatment of diffuse intrinsic pontine glioma DIPG (dpeaa)DE-He213 EZH2 inhibitor (dpeaa)DE-He213 BET inhibitor (dpeaa)DE-He213 Epigenetics (dpeaa)DE-He213 Tumor therapy (dpeaa)DE-He213
topic	ddc 050 misc DIPG misc EZH2 inhibitor misc BET inhibitor misc Epigenetics misc Tumor therapy
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title	Combination of EZH2 inhibitor and BET inhibitor for treatment of diffuse intrinsic pontine glioma
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title_full	Combination of EZH2 inhibitor and BET inhibitor for treatment of diffuse intrinsic pontine glioma
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title_sort	combination of ezh2 inhibitor and bet inhibitor for treatment of diffuse intrinsic pontine glioma
title_auth	Combination of EZH2 inhibitor and BET inhibitor for treatment of diffuse intrinsic pontine glioma
abstract	Background Diffuse intrinsic pontine glioma is an infiltrative, often high-grade glioma of the brainstem that is not amenable to surgical resection. The current treatment of DIPG by radiation therapy showed dramatically improvement of patient’s condition, however, the tumor recurs rapidly. More and more studies are focused on the genetic and epigenetic drivers of DIPGs, which may provide more and more novel therapy target for DIPG. EZH2 has been proved to be a potential therapeutic target for H3K27M-mutant pediatric gliomas recently. Meanwhile, BET family protein is a hot target in many different types of cancers, including DIPG. In this study, we performed the treatment of both EZH2 and BET inhibitor for DIPG cells. Results The combination of these two inhibitors exhibited better inhibition of the tumor growth both in vitro and in vivo compared to use the inhibitor individually. This inhibition was performed by blocking the proliferation and promoting the cell apoptosis. Meanwhile, combination treatment of these two inhibitors would also affect the epigenetic markers which were abnormal in the tumors of the certain set of genes. Conclusion Thus we provided a novel therapy strategy for clinical treatment of DIPG.
abstractGer	Background Diffuse intrinsic pontine glioma is an infiltrative, often high-grade glioma of the brainstem that is not amenable to surgical resection. The current treatment of DIPG by radiation therapy showed dramatically improvement of patient’s condition, however, the tumor recurs rapidly. More and more studies are focused on the genetic and epigenetic drivers of DIPGs, which may provide more and more novel therapy target for DIPG. EZH2 has been proved to be a potential therapeutic target for H3K27M-mutant pediatric gliomas recently. Meanwhile, BET family protein is a hot target in many different types of cancers, including DIPG. In this study, we performed the treatment of both EZH2 and BET inhibitor for DIPG cells. Results The combination of these two inhibitors exhibited better inhibition of the tumor growth both in vitro and in vivo compared to use the inhibitor individually. This inhibition was performed by blocking the proliferation and promoting the cell apoptosis. Meanwhile, combination treatment of these two inhibitors would also affect the epigenetic markers which were abnormal in the tumors of the certain set of genes. Conclusion Thus we provided a novel therapy strategy for clinical treatment of DIPG.
abstract_unstemmed	Background Diffuse intrinsic pontine glioma is an infiltrative, often high-grade glioma of the brainstem that is not amenable to surgical resection. The current treatment of DIPG by radiation therapy showed dramatically improvement of patient’s condition, however, the tumor recurs rapidly. More and more studies are focused on the genetic and epigenetic drivers of DIPGs, which may provide more and more novel therapy target for DIPG. EZH2 has been proved to be a potential therapeutic target for H3K27M-mutant pediatric gliomas recently. Meanwhile, BET family protein is a hot target in many different types of cancers, including DIPG. In this study, we performed the treatment of both EZH2 and BET inhibitor for DIPG cells. Results The combination of these two inhibitors exhibited better inhibition of the tumor growth both in vitro and in vivo compared to use the inhibitor individually. This inhibition was performed by blocking the proliferation and promoting the cell apoptosis. Meanwhile, combination treatment of these two inhibitors would also affect the epigenetic markers which were abnormal in the tumors of the certain set of genes. Conclusion Thus we provided a novel therapy strategy for clinical treatment of DIPG.
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title_short	Combination of EZH2 inhibitor and BET inhibitor for treatment of diffuse intrinsic pontine glioma
url	https://dx.doi.org/10.1186/s13578-017-0184-0
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author2	Dong, Weijie Zhu, Junying Wang, Lizhu Wu, Xinjian Shan, Hong
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