Medial prefrontal cortex serotonin 1A and 2A receptor binding interacts to predict threat-related amygdala reactivity

Background The amygdala and medial prefrontal cortex (mPFC) comprise a key corticolimbic circuit that helps shape individual differences in sensitivity to threat and the related risk for psychopathology. Although serotonin (5-HT) is known to be a key modulator of this circuit, the specific receptors...
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Gespeichert in:

Autor*in:	Fisher, Patrick M [verfasserIn] Price, Julie C [verfasserIn] Meltzer, Carolyn C [verfasserIn] Moses-Kolko, Eydie L [verfasserIn] Becker, Carl [verfasserIn] Berga, Sarah L [verfasserIn] Hariri, Ahmad R [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2011

Schlagwörter:	Positron Emission Tomography Glutamatergic Neuron Amygdala Reactivity Serotonergic Modulation Positron Emission Tomography Technique

Übergeordnetes Werk:	Enthalten in: Biology of mood & anxiety disorders - London : BioMed Central, 2011, 1(2011), 1 vom: 27. Sept.
Übergeordnetes Werk:	volume:1 ; year:2011 ; number:1 ; day:27 ; month:09

Links:	Volltext

DOI / URN:	10.1186/2045-5380-1-2

Katalog-ID:	SPR031871437

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520			\|a Background The amygdala and medial prefrontal cortex (mPFC) comprise a key corticolimbic circuit that helps shape individual differences in sensitivity to threat and the related risk for psychopathology. Although serotonin (5-HT) is known to be a key modulator of this circuit, the specific receptors mediating this modulation are unclear. The colocalization of 5-$ HT_{1A} $ and 5-$ HT_{2A} $ receptors on mPFC glutamatergic neurons suggests that their functional interactions may mediate 5-HT effects on this circuit through top-down regulation of amygdala reactivity. Using a multimodal neuroimaging strategy in 39 healthy volunteers, we determined whether threat-related amygdala reactivity, assessed with blood oxygen level-dependent functional magnetic resonance imaging, was significantly predicted by the interaction between mPFC 5-$ HT_{1A} $ and 5-$ HT_{2A} $ receptor levels, assessed by positron emission tomography. Results 5-$ HT_{1A} $ binding in the mPFC significantly moderated an inverse correlation between mPFC 5-$ HT_{2A} $ binding and threat-related amygdala reactivity. Specifically, mPFC 5-$ HT_{2A} $ binding was significantly inversely correlated with amygdala reactivity only when mPFC 5-$ HT_{1A} $ binding was relatively low. Conclusions Our findings provide evidence that 5-$ HT_{1A} $ and 5-$ HT_{2A} $ receptors interact to shape serotonergic modulation of a functional circuit between the amygdala and mPFC. The effect of the interaction between mPFC 5-$ HT_{1A} $ and 5-$ HT_{2A} $ binding and amygdala reactivity is consistent with the colocalization of these receptors on glutamatergic neurons in the mPFC.
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allfields	10.1186/2045-5380-1-2 doi (DE-627)SPR031871437 (SPR)2045-5380-1-2-e DE-627 ger DE-627 rakwb eng 610 ASE Fisher, Patrick M verfasserin aut Medial prefrontal cortex serotonin 1A and 2A receptor binding interacts to predict threat-related amygdala reactivity 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The amygdala and medial prefrontal cortex (mPFC) comprise a key corticolimbic circuit that helps shape individual differences in sensitivity to threat and the related risk for psychopathology. Although serotonin (5-HT) is known to be a key modulator of this circuit, the specific receptors mediating this modulation are unclear. The colocalization of 5-$ HT_{1A} $ and 5-$ HT_{2A} $ receptors on mPFC glutamatergic neurons suggests that their functional interactions may mediate 5-HT effects on this circuit through top-down regulation of amygdala reactivity. Using a multimodal neuroimaging strategy in 39 healthy volunteers, we determined whether threat-related amygdala reactivity, assessed with blood oxygen level-dependent functional magnetic resonance imaging, was significantly predicted by the interaction between mPFC 5-$ HT_{1A} $ and 5-$ HT_{2A} $ receptor levels, assessed by positron emission tomography. Results 5-$ HT_{1A} $ binding in the mPFC significantly moderated an inverse correlation between mPFC 5-$ HT_{2A} $ binding and threat-related amygdala reactivity. Specifically, mPFC 5-$ HT_{2A} $ binding was significantly inversely correlated with amygdala reactivity only when mPFC 5-$ HT_{1A} $ binding was relatively low. Conclusions Our findings provide evidence that 5-$ HT_{1A} $ and 5-$ HT_{2A} $ receptors interact to shape serotonergic modulation of a functional circuit between the amygdala and mPFC. The effect of the interaction between mPFC 5-$ HT_{1A} $ and 5-$ HT_{2A} $ binding and amygdala reactivity is consistent with the colocalization of these receptors on glutamatergic neurons in the mPFC. Positron Emission Tomography (dpeaa)DE-He213 Glutamatergic Neuron (dpeaa)DE-He213 Amygdala Reactivity (dpeaa)DE-He213 Serotonergic Modulation (dpeaa)DE-He213 Positron Emission Tomography Technique (dpeaa)DE-He213 Price, Julie C verfasserin aut Meltzer, Carolyn C verfasserin aut Moses-Kolko, Eydie L verfasserin aut Becker, Carl verfasserin aut Berga, Sarah L verfasserin aut Hariri, Ahmad R verfasserin aut Enthalten in Biology of mood & anxiety disorders London : BioMed Central, 2011 1(2011), 1 vom: 27. Sept. (DE-627)687718074 (DE-600)2651986-0 2045-5380 nnns volume:1 year:2011 number:1 day:27 month:09 https://dx.doi.org/10.1186/2045-5380-1-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2011 1 27 09
spelling	10.1186/2045-5380-1-2 doi (DE-627)SPR031871437 (SPR)2045-5380-1-2-e DE-627 ger DE-627 rakwb eng 610 ASE Fisher, Patrick M verfasserin aut Medial prefrontal cortex serotonin 1A and 2A receptor binding interacts to predict threat-related amygdala reactivity 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The amygdala and medial prefrontal cortex (mPFC) comprise a key corticolimbic circuit that helps shape individual differences in sensitivity to threat and the related risk for psychopathology. Although serotonin (5-HT) is known to be a key modulator of this circuit, the specific receptors mediating this modulation are unclear. The colocalization of 5-$ HT_{1A} $ and 5-$ HT_{2A} $ receptors on mPFC glutamatergic neurons suggests that their functional interactions may mediate 5-HT effects on this circuit through top-down regulation of amygdala reactivity. Using a multimodal neuroimaging strategy in 39 healthy volunteers, we determined whether threat-related amygdala reactivity, assessed with blood oxygen level-dependent functional magnetic resonance imaging, was significantly predicted by the interaction between mPFC 5-$ HT_{1A} $ and 5-$ HT_{2A} $ receptor levels, assessed by positron emission tomography. Results 5-$ HT_{1A} $ binding in the mPFC significantly moderated an inverse correlation between mPFC 5-$ HT_{2A} $ binding and threat-related amygdala reactivity. Specifically, mPFC 5-$ HT_{2A} $ binding was significantly inversely correlated with amygdala reactivity only when mPFC 5-$ HT_{1A} $ binding was relatively low. Conclusions Our findings provide evidence that 5-$ HT_{1A} $ and 5-$ HT_{2A} $ receptors interact to shape serotonergic modulation of a functional circuit between the amygdala and mPFC. The effect of the interaction between mPFC 5-$ HT_{1A} $ and 5-$ HT_{2A} $ binding and amygdala reactivity is consistent with the colocalization of these receptors on glutamatergic neurons in the mPFC. Positron Emission Tomography (dpeaa)DE-He213 Glutamatergic Neuron (dpeaa)DE-He213 Amygdala Reactivity (dpeaa)DE-He213 Serotonergic Modulation (dpeaa)DE-He213 Positron Emission Tomography Technique (dpeaa)DE-He213 Price, Julie C verfasserin aut Meltzer, Carolyn C verfasserin aut Moses-Kolko, Eydie L verfasserin aut Becker, Carl verfasserin aut Berga, Sarah L verfasserin aut Hariri, Ahmad R verfasserin aut Enthalten in Biology of mood & anxiety disorders London : BioMed Central, 2011 1(2011), 1 vom: 27. Sept. (DE-627)687718074 (DE-600)2651986-0 2045-5380 nnns volume:1 year:2011 number:1 day:27 month:09 https://dx.doi.org/10.1186/2045-5380-1-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2011 1 27 09
allfields_unstemmed	10.1186/2045-5380-1-2 doi (DE-627)SPR031871437 (SPR)2045-5380-1-2-e DE-627 ger DE-627 rakwb eng 610 ASE Fisher, Patrick M verfasserin aut Medial prefrontal cortex serotonin 1A and 2A receptor binding interacts to predict threat-related amygdala reactivity 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The amygdala and medial prefrontal cortex (mPFC) comprise a key corticolimbic circuit that helps shape individual differences in sensitivity to threat and the related risk for psychopathology. Although serotonin (5-HT) is known to be a key modulator of this circuit, the specific receptors mediating this modulation are unclear. The colocalization of 5-$ HT_{1A} $ and 5-$ HT_{2A} $ receptors on mPFC glutamatergic neurons suggests that their functional interactions may mediate 5-HT effects on this circuit through top-down regulation of amygdala reactivity. Using a multimodal neuroimaging strategy in 39 healthy volunteers, we determined whether threat-related amygdala reactivity, assessed with blood oxygen level-dependent functional magnetic resonance imaging, was significantly predicted by the interaction between mPFC 5-$ HT_{1A} $ and 5-$ HT_{2A} $ receptor levels, assessed by positron emission tomography. Results 5-$ HT_{1A} $ binding in the mPFC significantly moderated an inverse correlation between mPFC 5-$ HT_{2A} $ binding and threat-related amygdala reactivity. Specifically, mPFC 5-$ HT_{2A} $ binding was significantly inversely correlated with amygdala reactivity only when mPFC 5-$ HT_{1A} $ binding was relatively low. Conclusions Our findings provide evidence that 5-$ HT_{1A} $ and 5-$ HT_{2A} $ receptors interact to shape serotonergic modulation of a functional circuit between the amygdala and mPFC. The effect of the interaction between mPFC 5-$ HT_{1A} $ and 5-$ HT_{2A} $ binding and amygdala reactivity is consistent with the colocalization of these receptors on glutamatergic neurons in the mPFC. Positron Emission Tomography (dpeaa)DE-He213 Glutamatergic Neuron (dpeaa)DE-He213 Amygdala Reactivity (dpeaa)DE-He213 Serotonergic Modulation (dpeaa)DE-He213 Positron Emission Tomography Technique (dpeaa)DE-He213 Price, Julie C verfasserin aut Meltzer, Carolyn C verfasserin aut Moses-Kolko, Eydie L verfasserin aut Becker, Carl verfasserin aut Berga, Sarah L verfasserin aut Hariri, Ahmad R verfasserin aut Enthalten in Biology of mood & anxiety disorders London : BioMed Central, 2011 1(2011), 1 vom: 27. Sept. (DE-627)687718074 (DE-600)2651986-0 2045-5380 nnns volume:1 year:2011 number:1 day:27 month:09 https://dx.doi.org/10.1186/2045-5380-1-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2011 1 27 09
allfieldsGer	10.1186/2045-5380-1-2 doi (DE-627)SPR031871437 (SPR)2045-5380-1-2-e DE-627 ger DE-627 rakwb eng 610 ASE Fisher, Patrick M verfasserin aut Medial prefrontal cortex serotonin 1A and 2A receptor binding interacts to predict threat-related amygdala reactivity 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The amygdala and medial prefrontal cortex (mPFC) comprise a key corticolimbic circuit that helps shape individual differences in sensitivity to threat and the related risk for psychopathology. Although serotonin (5-HT) is known to be a key modulator of this circuit, the specific receptors mediating this modulation are unclear. The colocalization of 5-$ HT_{1A} $ and 5-$ HT_{2A} $ receptors on mPFC glutamatergic neurons suggests that their functional interactions may mediate 5-HT effects on this circuit through top-down regulation of amygdala reactivity. Using a multimodal neuroimaging strategy in 39 healthy volunteers, we determined whether threat-related amygdala reactivity, assessed with blood oxygen level-dependent functional magnetic resonance imaging, was significantly predicted by the interaction between mPFC 5-$ HT_{1A} $ and 5-$ HT_{2A} $ receptor levels, assessed by positron emission tomography. Results 5-$ HT_{1A} $ binding in the mPFC significantly moderated an inverse correlation between mPFC 5-$ HT_{2A} $ binding and threat-related amygdala reactivity. Specifically, mPFC 5-$ HT_{2A} $ binding was significantly inversely correlated with amygdala reactivity only when mPFC 5-$ HT_{1A} $ binding was relatively low. Conclusions Our findings provide evidence that 5-$ HT_{1A} $ and 5-$ HT_{2A} $ receptors interact to shape serotonergic modulation of a functional circuit between the amygdala and mPFC. The effect of the interaction between mPFC 5-$ HT_{1A} $ and 5-$ HT_{2A} $ binding and amygdala reactivity is consistent with the colocalization of these receptors on glutamatergic neurons in the mPFC. Positron Emission Tomography (dpeaa)DE-He213 Glutamatergic Neuron (dpeaa)DE-He213 Amygdala Reactivity (dpeaa)DE-He213 Serotonergic Modulation (dpeaa)DE-He213 Positron Emission Tomography Technique (dpeaa)DE-He213 Price, Julie C verfasserin aut Meltzer, Carolyn C verfasserin aut Moses-Kolko, Eydie L verfasserin aut Becker, Carl verfasserin aut Berga, Sarah L verfasserin aut Hariri, Ahmad R verfasserin aut Enthalten in Biology of mood & anxiety disorders London : BioMed Central, 2011 1(2011), 1 vom: 27. Sept. (DE-627)687718074 (DE-600)2651986-0 2045-5380 nnns volume:1 year:2011 number:1 day:27 month:09 https://dx.doi.org/10.1186/2045-5380-1-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2011 1 27 09
allfieldsSound	10.1186/2045-5380-1-2 doi (DE-627)SPR031871437 (SPR)2045-5380-1-2-e DE-627 ger DE-627 rakwb eng 610 ASE Fisher, Patrick M verfasserin aut Medial prefrontal cortex serotonin 1A and 2A receptor binding interacts to predict threat-related amygdala reactivity 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The amygdala and medial prefrontal cortex (mPFC) comprise a key corticolimbic circuit that helps shape individual differences in sensitivity to threat and the related risk for psychopathology. Although serotonin (5-HT) is known to be a key modulator of this circuit, the specific receptors mediating this modulation are unclear. The colocalization of 5-$ HT_{1A} $ and 5-$ HT_{2A} $ receptors on mPFC glutamatergic neurons suggests that their functional interactions may mediate 5-HT effects on this circuit through top-down regulation of amygdala reactivity. Using a multimodal neuroimaging strategy in 39 healthy volunteers, we determined whether threat-related amygdala reactivity, assessed with blood oxygen level-dependent functional magnetic resonance imaging, was significantly predicted by the interaction between mPFC 5-$ HT_{1A} $ and 5-$ HT_{2A} $ receptor levels, assessed by positron emission tomography. Results 5-$ HT_{1A} $ binding in the mPFC significantly moderated an inverse correlation between mPFC 5-$ HT_{2A} $ binding and threat-related amygdala reactivity. Specifically, mPFC 5-$ HT_{2A} $ binding was significantly inversely correlated with amygdala reactivity only when mPFC 5-$ HT_{1A} $ binding was relatively low. Conclusions Our findings provide evidence that 5-$ HT_{1A} $ and 5-$ HT_{2A} $ receptors interact to shape serotonergic modulation of a functional circuit between the amygdala and mPFC. The effect of the interaction between mPFC 5-$ HT_{1A} $ and 5-$ HT_{2A} $ binding and amygdala reactivity is consistent with the colocalization of these receptors on glutamatergic neurons in the mPFC. Positron Emission Tomography (dpeaa)DE-He213 Glutamatergic Neuron (dpeaa)DE-He213 Amygdala Reactivity (dpeaa)DE-He213 Serotonergic Modulation (dpeaa)DE-He213 Positron Emission Tomography Technique (dpeaa)DE-He213 Price, Julie C verfasserin aut Meltzer, Carolyn C verfasserin aut Moses-Kolko, Eydie L verfasserin aut Becker, Carl verfasserin aut Berga, Sarah L verfasserin aut Hariri, Ahmad R verfasserin aut Enthalten in Biology of mood & anxiety disorders London : BioMed Central, 2011 1(2011), 1 vom: 27. Sept. (DE-627)687718074 (DE-600)2651986-0 2045-5380 nnns volume:1 year:2011 number:1 day:27 month:09 https://dx.doi.org/10.1186/2045-5380-1-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2011 1 27 09
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Although serotonin (5-HT) is known to be a key modulator of this circuit, the specific receptors mediating this modulation are unclear. The colocalization of 5-$ HT_{1A} $ and 5-$ HT_{2A} $ receptors on mPFC glutamatergic neurons suggests that their functional interactions may mediate 5-HT effects on this circuit through top-down regulation of amygdala reactivity. Using a multimodal neuroimaging strategy in 39 healthy volunteers, we determined whether threat-related amygdala reactivity, assessed with blood oxygen level-dependent functional magnetic resonance imaging, was significantly predicted by the interaction between mPFC 5-$ HT_{1A} $ and 5-$ HT_{2A} $ receptor levels, assessed by positron emission tomography. Results 5-$ HT_{1A} $ binding in the mPFC significantly moderated an inverse correlation between mPFC 5-$ HT_{2A} $ binding and threat-related amygdala reactivity. Specifically, mPFC 5-$ HT_{2A} $ binding was significantly inversely correlated with amygdala reactivity only when mPFC 5-$ HT_{1A} $ binding was relatively low. Conclusions Our findings provide evidence that 5-$ HT_{1A} $ and 5-$ HT_{2A} $ receptors interact to shape serotonergic modulation of a functional circuit between the amygdala and mPFC. 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author	Fisher, Patrick M
spellingShingle	Fisher, Patrick M ddc 610 misc Positron Emission Tomography misc Glutamatergic Neuron misc Amygdala Reactivity misc Serotonergic Modulation misc Positron Emission Tomography Technique Medial prefrontal cortex serotonin 1A and 2A receptor binding interacts to predict threat-related amygdala reactivity
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topic_title	610 ASE Medial prefrontal cortex serotonin 1A and 2A receptor binding interacts to predict threat-related amygdala reactivity Positron Emission Tomography (dpeaa)DE-He213 Glutamatergic Neuron (dpeaa)DE-He213 Amygdala Reactivity (dpeaa)DE-He213 Serotonergic Modulation (dpeaa)DE-He213 Positron Emission Tomography Technique (dpeaa)DE-He213
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title	Medial prefrontal cortex serotonin 1A and 2A receptor binding interacts to predict threat-related amygdala reactivity
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title_full	Medial prefrontal cortex serotonin 1A and 2A receptor binding interacts to predict threat-related amygdala reactivity
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title_sort	medial prefrontal cortex serotonin 1a and 2a receptor binding interacts to predict threat-related amygdala reactivity
title_auth	Medial prefrontal cortex serotonin 1A and 2A receptor binding interacts to predict threat-related amygdala reactivity
abstract	Background The amygdala and medial prefrontal cortex (mPFC) comprise a key corticolimbic circuit that helps shape individual differences in sensitivity to threat and the related risk for psychopathology. Although serotonin (5-HT) is known to be a key modulator of this circuit, the specific receptors mediating this modulation are unclear. The colocalization of 5-$ HT_{1A} $ and 5-$ HT_{2A} $ receptors on mPFC glutamatergic neurons suggests that their functional interactions may mediate 5-HT effects on this circuit through top-down regulation of amygdala reactivity. Using a multimodal neuroimaging strategy in 39 healthy volunteers, we determined whether threat-related amygdala reactivity, assessed with blood oxygen level-dependent functional magnetic resonance imaging, was significantly predicted by the interaction between mPFC 5-$ HT_{1A} $ and 5-$ HT_{2A} $ receptor levels, assessed by positron emission tomography. Results 5-$ HT_{1A} $ binding in the mPFC significantly moderated an inverse correlation between mPFC 5-$ HT_{2A} $ binding and threat-related amygdala reactivity. Specifically, mPFC 5-$ HT_{2A} $ binding was significantly inversely correlated with amygdala reactivity only when mPFC 5-$ HT_{1A} $ binding was relatively low. Conclusions Our findings provide evidence that 5-$ HT_{1A} $ and 5-$ HT_{2A} $ receptors interact to shape serotonergic modulation of a functional circuit between the amygdala and mPFC. The effect of the interaction between mPFC 5-$ HT_{1A} $ and 5-$ HT_{2A} $ binding and amygdala reactivity is consistent with the colocalization of these receptors on glutamatergic neurons in the mPFC.
abstractGer	Background The amygdala and medial prefrontal cortex (mPFC) comprise a key corticolimbic circuit that helps shape individual differences in sensitivity to threat and the related risk for psychopathology. Although serotonin (5-HT) is known to be a key modulator of this circuit, the specific receptors mediating this modulation are unclear. The colocalization of 5-$ HT_{1A} $ and 5-$ HT_{2A} $ receptors on mPFC glutamatergic neurons suggests that their functional interactions may mediate 5-HT effects on this circuit through top-down regulation of amygdala reactivity. Using a multimodal neuroimaging strategy in 39 healthy volunteers, we determined whether threat-related amygdala reactivity, assessed with blood oxygen level-dependent functional magnetic resonance imaging, was significantly predicted by the interaction between mPFC 5-$ HT_{1A} $ and 5-$ HT_{2A} $ receptor levels, assessed by positron emission tomography. Results 5-$ HT_{1A} $ binding in the mPFC significantly moderated an inverse correlation between mPFC 5-$ HT_{2A} $ binding and threat-related amygdala reactivity. Specifically, mPFC 5-$ HT_{2A} $ binding was significantly inversely correlated with amygdala reactivity only when mPFC 5-$ HT_{1A} $ binding was relatively low. Conclusions Our findings provide evidence that 5-$ HT_{1A} $ and 5-$ HT_{2A} $ receptors interact to shape serotonergic modulation of a functional circuit between the amygdala and mPFC. The effect of the interaction between mPFC 5-$ HT_{1A} $ and 5-$ HT_{2A} $ binding and amygdala reactivity is consistent with the colocalization of these receptors on glutamatergic neurons in the mPFC.
abstract_unstemmed	Background The amygdala and medial prefrontal cortex (mPFC) comprise a key corticolimbic circuit that helps shape individual differences in sensitivity to threat and the related risk for psychopathology. Although serotonin (5-HT) is known to be a key modulator of this circuit, the specific receptors mediating this modulation are unclear. The colocalization of 5-$ HT_{1A} $ and 5-$ HT_{2A} $ receptors on mPFC glutamatergic neurons suggests that their functional interactions may mediate 5-HT effects on this circuit through top-down regulation of amygdala reactivity. Using a multimodal neuroimaging strategy in 39 healthy volunteers, we determined whether threat-related amygdala reactivity, assessed with blood oxygen level-dependent functional magnetic resonance imaging, was significantly predicted by the interaction between mPFC 5-$ HT_{1A} $ and 5-$ HT_{2A} $ receptor levels, assessed by positron emission tomography. Results 5-$ HT_{1A} $ binding in the mPFC significantly moderated an inverse correlation between mPFC 5-$ HT_{2A} $ binding and threat-related amygdala reactivity. Specifically, mPFC 5-$ HT_{2A} $ binding was significantly inversely correlated with amygdala reactivity only when mPFC 5-$ HT_{1A} $ binding was relatively low. Conclusions Our findings provide evidence that 5-$ HT_{1A} $ and 5-$ HT_{2A} $ receptors interact to shape serotonergic modulation of a functional circuit between the amygdala and mPFC. The effect of the interaction between mPFC 5-$ HT_{1A} $ and 5-$ HT_{2A} $ binding and amygdala reactivity is consistent with the colocalization of these receptors on glutamatergic neurons in the mPFC.
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title_short	Medial prefrontal cortex serotonin 1A and 2A receptor binding interacts to predict threat-related amygdala reactivity
url	https://dx.doi.org/10.1186/2045-5380-1-2
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author2	Price, Julie C Meltzer, Carolyn C Moses-Kolko, Eydie L Becker, Carl Berga, Sarah L Hariri, Ahmad R
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Although serotonin (5-HT) is known to be a key modulator of this circuit, the specific receptors mediating this modulation are unclear. The colocalization of 5-$ HT_{1A} $ and 5-$ HT_{2A} $ receptors on mPFC glutamatergic neurons suggests that their functional interactions may mediate 5-HT effects on this circuit through top-down regulation of amygdala reactivity. Using a multimodal neuroimaging strategy in 39 healthy volunteers, we determined whether threat-related amygdala reactivity, assessed with blood oxygen level-dependent functional magnetic resonance imaging, was significantly predicted by the interaction between mPFC 5-$ HT_{1A} $ and 5-$ HT_{2A} $ receptor levels, assessed by positron emission tomography. Results 5-$ HT_{1A} $ binding in the mPFC significantly moderated an inverse correlation between mPFC 5-$ HT_{2A} $ binding and threat-related amygdala reactivity. Specifically, mPFC 5-$ HT_{2A} $ binding was significantly inversely correlated with amygdala reactivity only when mPFC 5-$ HT_{1A} $ binding was relatively low. Conclusions Our findings provide evidence that 5-$ HT_{1A} $ and 5-$ HT_{2A} $ receptors interact to shape serotonergic modulation of a functional circuit between the amygdala and mPFC. 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Medial prefrontal cortex serotonin 1A and 2A receptor binding interacts to predict threat-related amygdala reactivity

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