Antiplasmodial and antioxidant activities of chloroform extract of Ganoderma lucidum fruit body in Plasmodium berghei-infected mice

Abstract From our previous study extract of the fruit bodies of Ganoderma lucidum possessed promising curative potential against Plasmodium berghei in mice. Thus, we hypothesized that infection with chloroquine-sensitive Plasmodium berghei together with crude chloroform extract (CCE) of G. lucidum,...
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Autor*in:	Oluba, Olarewaju M. [verfasserIn] Josiah, Sunday J. [verfasserIn] Adebisi, Kayode E. [verfasserIn] Ojeaburu, Sam I. [verfasserIn] Chukwu Onyeneke, E. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	Chloroform extract Medicinal mushroom , oxidative stress

Übergeordnetes Werk:	Enthalten in: Oriental pharmacy and experimental medicine - Dordrecht : Springer, 2011, 17(2017), 4 vom: 24. Okt., Seite 389-395
Übergeordnetes Werk:	volume:17 ; year:2017 ; number:4 ; day:24 ; month:10 ; pages:389-395

Links:	Volltext

DOI / URN:	10.1007/s13596-017-0288-4

Katalog-ID:	SPR031906133

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245	1	0	\|a Antiplasmodial and antioxidant activities of chloroform extract of Ganoderma lucidum fruit body in Plasmodium berghei-infected mice
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520			\|a Abstract From our previous study extract of the fruit bodies of Ganoderma lucidum possessed promising curative potential against Plasmodium berghei in mice. Thus, we hypothesized that infection with chloroquine-sensitive Plasmodium berghei together with crude chloroform extract (CCE) of G. lucidum, at 250 mg/kg body weight would enhance various aspects of antiplasmodial activities in mice. Mice were treated with CCE or chloroquine (CQ) for seventy-two hours prior to infection with P. berghei and monitored closely until signs of death were observed in untreated mice and then sacrificed. Parasitaemia, hepatic function, and oxidative stress markers analyses were performed at the end of the experiment. CCE-treated mice displayed lower parasitemia compared with untreated mice. Plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltranspeptidase (γ-GT) activities; and the erythrocyte malondialdehyde (MDA) level were significantly (p<0.0001) lower in the extract and CQ-treated mice. Erythrocyte antioxidant enzymes (GPx, GST, SOD and G6PDH) activities were significantly (p<0.0001) higher in CCE-treated mice compared with CQ-treated and untreated control. Though chloroquine treatment reduced parasitemia and MDA considerably compared with extract, there was reduced production of the antioxidant defense enzymes. This study shows that CCE of G. lucidum reduces parasitemia and improves the attendant consequences of Plasmodium berghei-malarial infection in mice.
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700	1		\|a Adebisi, Kayode E. \|e verfasserin \|4 aut
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700	1		\|a Chukwu Onyeneke, E. \|e verfasserin \|4 aut
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912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_120
912			\|a GBV_ILN_138
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_171
912			\|a GBV_ILN_187
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
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912			\|a GBV_ILN_250
912			\|a GBV_ILN_281
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_370
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912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
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912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2031
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2037
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2039
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2057
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2070
912			\|a GBV_ILN_2086
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2093
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2107
912			\|a GBV_ILN_2108
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2111
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912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2116
912			\|a GBV_ILN_2118
912			\|a GBV_ILN_2119
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author_variant	o m o om omo s j j sj sjj k e a ke kea s i o si sio o e c oe oec
matchkey_str	article:22111069:2017----::nilsoilnatoiatciiisfhooomxrcogndrauiufutoy
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publishDate	2017
allfields	10.1007/s13596-017-0288-4 doi (DE-627)SPR031906133 (SPR)s13596-017-0288-4-e DE-627 ger DE-627 rakwb eng 610 ASE Oluba, Olarewaju M. verfasserin aut Antiplasmodial and antioxidant activities of chloroform extract of Ganoderma lucidum fruit body in Plasmodium berghei-infected mice 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract From our previous study extract of the fruit bodies of Ganoderma lucidum possessed promising curative potential against Plasmodium berghei in mice. Thus, we hypothesized that infection with chloroquine-sensitive Plasmodium berghei together with crude chloroform extract (CCE) of G. lucidum, at 250 mg/kg body weight would enhance various aspects of antiplasmodial activities in mice. Mice were treated with CCE or chloroquine (CQ) for seventy-two hours prior to infection with P. berghei and monitored closely until signs of death were observed in untreated mice and then sacrificed. Parasitaemia, hepatic function, and oxidative stress markers analyses were performed at the end of the experiment. CCE-treated mice displayed lower parasitemia compared with untreated mice. Plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltranspeptidase (γ-GT) activities; and the erythrocyte malondialdehyde (MDA) level were significantly (p<0.0001) lower in the extract and CQ-treated mice. Erythrocyte antioxidant enzymes (GPx, GST, SOD and G6PDH) activities were significantly (p<0.0001) higher in CCE-treated mice compared with CQ-treated and untreated control. Though chloroquine treatment reduced parasitemia and MDA considerably compared with extract, there was reduced production of the antioxidant defense enzymes. This study shows that CCE of G. lucidum reduces parasitemia and improves the attendant consequences of Plasmodium berghei-malarial infection in mice. Chloroform extract (dpeaa)DE-He213 Medicinal mushroom (dpeaa)DE-He213 , oxidative stress (dpeaa)DE-He213 Josiah, Sunday J. verfasserin aut Adebisi, Kayode E. verfasserin aut Ojeaburu, Sam I. verfasserin aut Chukwu Onyeneke, E. verfasserin aut Enthalten in Oriental pharmacy and experimental medicine Dordrecht : Springer, 2011 17(2017), 4 vom: 24. Okt., Seite 389-395 (DE-627)689127340 (DE-600)2655275-9 2211-1069 nnns volume:17 year:2017 number:4 day:24 month:10 pages:389-395 https://dx.doi.org/10.1007/s13596-017-0288-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 17 2017 4 24 10 389-395
spelling	10.1007/s13596-017-0288-4 doi (DE-627)SPR031906133 (SPR)s13596-017-0288-4-e DE-627 ger DE-627 rakwb eng 610 ASE Oluba, Olarewaju M. verfasserin aut Antiplasmodial and antioxidant activities of chloroform extract of Ganoderma lucidum fruit body in Plasmodium berghei-infected mice 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract From our previous study extract of the fruit bodies of Ganoderma lucidum possessed promising curative potential against Plasmodium berghei in mice. Thus, we hypothesized that infection with chloroquine-sensitive Plasmodium berghei together with crude chloroform extract (CCE) of G. lucidum, at 250 mg/kg body weight would enhance various aspects of antiplasmodial activities in mice. Mice were treated with CCE or chloroquine (CQ) for seventy-two hours prior to infection with P. berghei and monitored closely until signs of death were observed in untreated mice and then sacrificed. Parasitaemia, hepatic function, and oxidative stress markers analyses were performed at the end of the experiment. CCE-treated mice displayed lower parasitemia compared with untreated mice. Plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltranspeptidase (γ-GT) activities; and the erythrocyte malondialdehyde (MDA) level were significantly (p<0.0001) lower in the extract and CQ-treated mice. Erythrocyte antioxidant enzymes (GPx, GST, SOD and G6PDH) activities were significantly (p<0.0001) higher in CCE-treated mice compared with CQ-treated and untreated control. Though chloroquine treatment reduced parasitemia and MDA considerably compared with extract, there was reduced production of the antioxidant defense enzymes. This study shows that CCE of G. lucidum reduces parasitemia and improves the attendant consequences of Plasmodium berghei-malarial infection in mice. Chloroform extract (dpeaa)DE-He213 Medicinal mushroom (dpeaa)DE-He213 , oxidative stress (dpeaa)DE-He213 Josiah, Sunday J. verfasserin aut Adebisi, Kayode E. verfasserin aut Ojeaburu, Sam I. verfasserin aut Chukwu Onyeneke, E. verfasserin aut Enthalten in Oriental pharmacy and experimental medicine Dordrecht : Springer, 2011 17(2017), 4 vom: 24. Okt., Seite 389-395 (DE-627)689127340 (DE-600)2655275-9 2211-1069 nnns volume:17 year:2017 number:4 day:24 month:10 pages:389-395 https://dx.doi.org/10.1007/s13596-017-0288-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 17 2017 4 24 10 389-395
allfields_unstemmed	10.1007/s13596-017-0288-4 doi (DE-627)SPR031906133 (SPR)s13596-017-0288-4-e DE-627 ger DE-627 rakwb eng 610 ASE Oluba, Olarewaju M. verfasserin aut Antiplasmodial and antioxidant activities of chloroform extract of Ganoderma lucidum fruit body in Plasmodium berghei-infected mice 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract From our previous study extract of the fruit bodies of Ganoderma lucidum possessed promising curative potential against Plasmodium berghei in mice. Thus, we hypothesized that infection with chloroquine-sensitive Plasmodium berghei together with crude chloroform extract (CCE) of G. lucidum, at 250 mg/kg body weight would enhance various aspects of antiplasmodial activities in mice. Mice were treated with CCE or chloroquine (CQ) for seventy-two hours prior to infection with P. berghei and monitored closely until signs of death were observed in untreated mice and then sacrificed. Parasitaemia, hepatic function, and oxidative stress markers analyses were performed at the end of the experiment. CCE-treated mice displayed lower parasitemia compared with untreated mice. Plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltranspeptidase (γ-GT) activities; and the erythrocyte malondialdehyde (MDA) level were significantly (p<0.0001) lower in the extract and CQ-treated mice. Erythrocyte antioxidant enzymes (GPx, GST, SOD and G6PDH) activities were significantly (p<0.0001) higher in CCE-treated mice compared with CQ-treated and untreated control. Though chloroquine treatment reduced parasitemia and MDA considerably compared with extract, there was reduced production of the antioxidant defense enzymes. This study shows that CCE of G. lucidum reduces parasitemia and improves the attendant consequences of Plasmodium berghei-malarial infection in mice. Chloroform extract (dpeaa)DE-He213 Medicinal mushroom (dpeaa)DE-He213 , oxidative stress (dpeaa)DE-He213 Josiah, Sunday J. verfasserin aut Adebisi, Kayode E. verfasserin aut Ojeaburu, Sam I. verfasserin aut Chukwu Onyeneke, E. verfasserin aut Enthalten in Oriental pharmacy and experimental medicine Dordrecht : Springer, 2011 17(2017), 4 vom: 24. Okt., Seite 389-395 (DE-627)689127340 (DE-600)2655275-9 2211-1069 nnns volume:17 year:2017 number:4 day:24 month:10 pages:389-395 https://dx.doi.org/10.1007/s13596-017-0288-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 17 2017 4 24 10 389-395
allfieldsGer	10.1007/s13596-017-0288-4 doi (DE-627)SPR031906133 (SPR)s13596-017-0288-4-e DE-627 ger DE-627 rakwb eng 610 ASE Oluba, Olarewaju M. verfasserin aut Antiplasmodial and antioxidant activities of chloroform extract of Ganoderma lucidum fruit body in Plasmodium berghei-infected mice 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract From our previous study extract of the fruit bodies of Ganoderma lucidum possessed promising curative potential against Plasmodium berghei in mice. Thus, we hypothesized that infection with chloroquine-sensitive Plasmodium berghei together with crude chloroform extract (CCE) of G. lucidum, at 250 mg/kg body weight would enhance various aspects of antiplasmodial activities in mice. Mice were treated with CCE or chloroquine (CQ) for seventy-two hours prior to infection with P. berghei and monitored closely until signs of death were observed in untreated mice and then sacrificed. Parasitaemia, hepatic function, and oxidative stress markers analyses were performed at the end of the experiment. CCE-treated mice displayed lower parasitemia compared with untreated mice. Plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltranspeptidase (γ-GT) activities; and the erythrocyte malondialdehyde (MDA) level were significantly (p<0.0001) lower in the extract and CQ-treated mice. Erythrocyte antioxidant enzymes (GPx, GST, SOD and G6PDH) activities were significantly (p<0.0001) higher in CCE-treated mice compared with CQ-treated and untreated control. Though chloroquine treatment reduced parasitemia and MDA considerably compared with extract, there was reduced production of the antioxidant defense enzymes. This study shows that CCE of G. lucidum reduces parasitemia and improves the attendant consequences of Plasmodium berghei-malarial infection in mice. Chloroform extract (dpeaa)DE-He213 Medicinal mushroom (dpeaa)DE-He213 , oxidative stress (dpeaa)DE-He213 Josiah, Sunday J. verfasserin aut Adebisi, Kayode E. verfasserin aut Ojeaburu, Sam I. verfasserin aut Chukwu Onyeneke, E. verfasserin aut Enthalten in Oriental pharmacy and experimental medicine Dordrecht : Springer, 2011 17(2017), 4 vom: 24. Okt., Seite 389-395 (DE-627)689127340 (DE-600)2655275-9 2211-1069 nnns volume:17 year:2017 number:4 day:24 month:10 pages:389-395 https://dx.doi.org/10.1007/s13596-017-0288-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 17 2017 4 24 10 389-395
allfieldsSound	10.1007/s13596-017-0288-4 doi (DE-627)SPR031906133 (SPR)s13596-017-0288-4-e DE-627 ger DE-627 rakwb eng 610 ASE Oluba, Olarewaju M. verfasserin aut Antiplasmodial and antioxidant activities of chloroform extract of Ganoderma lucidum fruit body in Plasmodium berghei-infected mice 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract From our previous study extract of the fruit bodies of Ganoderma lucidum possessed promising curative potential against Plasmodium berghei in mice. Thus, we hypothesized that infection with chloroquine-sensitive Plasmodium berghei together with crude chloroform extract (CCE) of G. lucidum, at 250 mg/kg body weight would enhance various aspects of antiplasmodial activities in mice. Mice were treated with CCE or chloroquine (CQ) for seventy-two hours prior to infection with P. berghei and monitored closely until signs of death were observed in untreated mice and then sacrificed. Parasitaemia, hepatic function, and oxidative stress markers analyses were performed at the end of the experiment. CCE-treated mice displayed lower parasitemia compared with untreated mice. Plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltranspeptidase (γ-GT) activities; and the erythrocyte malondialdehyde (MDA) level were significantly (p<0.0001) lower in the extract and CQ-treated mice. Erythrocyte antioxidant enzymes (GPx, GST, SOD and G6PDH) activities were significantly (p<0.0001) higher in CCE-treated mice compared with CQ-treated and untreated control. Though chloroquine treatment reduced parasitemia and MDA considerably compared with extract, there was reduced production of the antioxidant defense enzymes. This study shows that CCE of G. lucidum reduces parasitemia and improves the attendant consequences of Plasmodium berghei-malarial infection in mice. Chloroform extract (dpeaa)DE-He213 Medicinal mushroom (dpeaa)DE-He213 , oxidative stress (dpeaa)DE-He213 Josiah, Sunday J. verfasserin aut Adebisi, Kayode E. verfasserin aut Ojeaburu, Sam I. verfasserin aut Chukwu Onyeneke, E. verfasserin aut Enthalten in Oriental pharmacy and experimental medicine Dordrecht : Springer, 2011 17(2017), 4 vom: 24. Okt., Seite 389-395 (DE-627)689127340 (DE-600)2655275-9 2211-1069 nnns volume:17 year:2017 number:4 day:24 month:10 pages:389-395 https://dx.doi.org/10.1007/s13596-017-0288-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 17 2017 4 24 10 389-395
language	English
source	Enthalten in Oriental pharmacy and experimental medicine 17(2017), 4 vom: 24. Okt., Seite 389-395 volume:17 year:2017 number:4 day:24 month:10 pages:389-395
sourceStr	Enthalten in Oriental pharmacy and experimental medicine 17(2017), 4 vom: 24. Okt., Seite 389-395 volume:17 year:2017 number:4 day:24 month:10 pages:389-395
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Chloroform extract Medicinal mushroom , oxidative stress
dewey-raw	610
isfreeaccess_bool	false
container_title	Oriental pharmacy and experimental medicine
authorswithroles_txt_mv	Oluba, Olarewaju M. @@aut@@ Josiah, Sunday J. @@aut@@ Adebisi, Kayode E. @@aut@@ Ojeaburu, Sam I. @@aut@@ Chukwu Onyeneke, E. @@aut@@
publishDateDaySort_date	2017-10-24T00:00:00Z
hierarchy_top_id	689127340
dewey-sort	3610
id	SPR031906133
language_de	englisch
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author	Oluba, Olarewaju M.
spellingShingle	Oluba, Olarewaju M. ddc 610 misc Chloroform extract misc Medicinal mushroom misc , oxidative stress Antiplasmodial and antioxidant activities of chloroform extract of Ganoderma lucidum fruit body in Plasmodium berghei-infected mice
authorStr	Oluba, Olarewaju M.
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topic_title	610 ASE Antiplasmodial and antioxidant activities of chloroform extract of Ganoderma lucidum fruit body in Plasmodium berghei-infected mice Chloroform extract (dpeaa)DE-He213 Medicinal mushroom (dpeaa)DE-He213 , oxidative stress (dpeaa)DE-He213
topic	ddc 610 misc Chloroform extract misc Medicinal mushroom misc , oxidative stress
topic_unstemmed	ddc 610 misc Chloroform extract misc Medicinal mushroom misc , oxidative stress
topic_browse	ddc 610 misc Chloroform extract misc Medicinal mushroom misc , oxidative stress
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title	Antiplasmodial and antioxidant activities of chloroform extract of Ganoderma lucidum fruit body in Plasmodium berghei-infected mice
ctrlnum	(DE-627)SPR031906133 (SPR)s13596-017-0288-4-e
title_full	Antiplasmodial and antioxidant activities of chloroform extract of Ganoderma lucidum fruit body in Plasmodium berghei-infected mice
author_sort	Oluba, Olarewaju M.
journal	Oriental pharmacy and experimental medicine
journalStr	Oriental pharmacy and experimental medicine
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author_browse	Oluba, Olarewaju M. Josiah, Sunday J. Adebisi, Kayode E. Ojeaburu, Sam I. Chukwu Onyeneke, E.
container_volume	17
class	610 ASE
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author-letter	Oluba, Olarewaju M.
doi_str_mv	10.1007/s13596-017-0288-4
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title_sort	antiplasmodial and antioxidant activities of chloroform extract of ganoderma lucidum fruit body in plasmodium berghei-infected mice
title_auth	Antiplasmodial and antioxidant activities of chloroform extract of Ganoderma lucidum fruit body in Plasmodium berghei-infected mice
abstract	Abstract From our previous study extract of the fruit bodies of Ganoderma lucidum possessed promising curative potential against Plasmodium berghei in mice. Thus, we hypothesized that infection with chloroquine-sensitive Plasmodium berghei together with crude chloroform extract (CCE) of G. lucidum, at 250 mg/kg body weight would enhance various aspects of antiplasmodial activities in mice. Mice were treated with CCE or chloroquine (CQ) for seventy-two hours prior to infection with P. berghei and monitored closely until signs of death were observed in untreated mice and then sacrificed. Parasitaemia, hepatic function, and oxidative stress markers analyses were performed at the end of the experiment. CCE-treated mice displayed lower parasitemia compared with untreated mice. Plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltranspeptidase (γ-GT) activities; and the erythrocyte malondialdehyde (MDA) level were significantly (p<0.0001) lower in the extract and CQ-treated mice. Erythrocyte antioxidant enzymes (GPx, GST, SOD and G6PDH) activities were significantly (p<0.0001) higher in CCE-treated mice compared with CQ-treated and untreated control. Though chloroquine treatment reduced parasitemia and MDA considerably compared with extract, there was reduced production of the antioxidant defense enzymes. This study shows that CCE of G. lucidum reduces parasitemia and improves the attendant consequences of Plasmodium berghei-malarial infection in mice.
abstractGer	Abstract From our previous study extract of the fruit bodies of Ganoderma lucidum possessed promising curative potential against Plasmodium berghei in mice. Thus, we hypothesized that infection with chloroquine-sensitive Plasmodium berghei together with crude chloroform extract (CCE) of G. lucidum, at 250 mg/kg body weight would enhance various aspects of antiplasmodial activities in mice. Mice were treated with CCE or chloroquine (CQ) for seventy-two hours prior to infection with P. berghei and monitored closely until signs of death were observed in untreated mice and then sacrificed. Parasitaemia, hepatic function, and oxidative stress markers analyses were performed at the end of the experiment. CCE-treated mice displayed lower parasitemia compared with untreated mice. Plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltranspeptidase (γ-GT) activities; and the erythrocyte malondialdehyde (MDA) level were significantly (p<0.0001) lower in the extract and CQ-treated mice. Erythrocyte antioxidant enzymes (GPx, GST, SOD and G6PDH) activities were significantly (p<0.0001) higher in CCE-treated mice compared with CQ-treated and untreated control. Though chloroquine treatment reduced parasitemia and MDA considerably compared with extract, there was reduced production of the antioxidant defense enzymes. This study shows that CCE of G. lucidum reduces parasitemia and improves the attendant consequences of Plasmodium berghei-malarial infection in mice.
abstract_unstemmed	Abstract From our previous study extract of the fruit bodies of Ganoderma lucidum possessed promising curative potential against Plasmodium berghei in mice. Thus, we hypothesized that infection with chloroquine-sensitive Plasmodium berghei together with crude chloroform extract (CCE) of G. lucidum, at 250 mg/kg body weight would enhance various aspects of antiplasmodial activities in mice. Mice were treated with CCE or chloroquine (CQ) for seventy-two hours prior to infection with P. berghei and monitored closely until signs of death were observed in untreated mice and then sacrificed. Parasitaemia, hepatic function, and oxidative stress markers analyses were performed at the end of the experiment. CCE-treated mice displayed lower parasitemia compared with untreated mice. Plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltranspeptidase (γ-GT) activities; and the erythrocyte malondialdehyde (MDA) level were significantly (p<0.0001) lower in the extract and CQ-treated mice. Erythrocyte antioxidant enzymes (GPx, GST, SOD and G6PDH) activities were significantly (p<0.0001) higher in CCE-treated mice compared with CQ-treated and untreated control. Though chloroquine treatment reduced parasitemia and MDA considerably compared with extract, there was reduced production of the antioxidant defense enzymes. This study shows that CCE of G. lucidum reduces parasitemia and improves the attendant consequences of Plasmodium berghei-malarial infection in mice.
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title_short	Antiplasmodial and antioxidant activities of chloroform extract of Ganoderma lucidum fruit body in Plasmodium berghei-infected mice
url	https://dx.doi.org/10.1007/s13596-017-0288-4
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author2	Josiah, Sunday J. Adebisi, Kayode E. Ojeaburu, Sam I. Chukwu Onyeneke, E.
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up_date	2024-07-04T01:46:31.406Z
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Thus, we hypothesized that infection with chloroquine-sensitive Plasmodium berghei together with crude chloroform extract (CCE) of G. lucidum, at 250 mg/kg body weight would enhance various aspects of antiplasmodial activities in mice. Mice were treated with CCE or chloroquine (CQ) for seventy-two hours prior to infection with P. berghei and monitored closely until signs of death were observed in untreated mice and then sacrificed. Parasitaemia, hepatic function, and oxidative stress markers analyses were performed at the end of the experiment. CCE-treated mice displayed lower parasitemia compared with untreated mice. Plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltranspeptidase (γ-GT) activities; and the erythrocyte malondialdehyde (MDA) level were significantly (p<0.0001) lower in the extract and CQ-treated mice. Erythrocyte antioxidant enzymes (GPx, GST, SOD and G6PDH) activities were significantly (p<0.0001) higher in CCE-treated mice compared with CQ-treated and untreated control. Though chloroquine treatment reduced parasitemia and MDA considerably compared with extract, there was reduced production of the antioxidant defense enzymes. 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Antiplasmodial and antioxidant activities of chloroform extract of Ganoderma lucidum fruit body in Plasmodium berghei-infected mice

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