Formulation development and pharmacological evaluation of fixed dose combination of Bombyx mori coccon shell extract, Flaxseed oil and coenzyme Q10 against doxorubicin induced cardiomyopathy in rats

Abstract The present study aims at formulation development and pharmacological evaluation of fixed dose combination of Bombyx mori (Abresham) extract, Flaxseed oil and coenzyme Q10 (CoQ10) against doxorubicin induced myocardial toxicity in rats. Formulation (emulsion) was prepared using dry gum meth...
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Autor*in:	Tarique, Mohammad [verfasserIn] Ahsan, Farogh [verfasserIn] Akhtar, Juber [verfasserIn] Khan, Mohammad Irfan [verfasserIn] Khalid, Mohammad [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Coenzyme Q10 Doxorubicin Flaxseed oil Myocardial infarction Cardiomyopathy

Übergeordnetes Werk:	Enthalten in: Oriental pharmacy and experimental medicine - Dordrecht : Springer, 2011, 19(2019), 4 vom: 16. März, Seite 469-483
Übergeordnetes Werk:	volume:19 ; year:2019 ; number:4 ; day:16 ; month:03 ; pages:469-483

Links:	Volltext

DOI / URN:	10.1007/s13596-019-00360-6

Katalog-ID:	SPR031907040

Internformat


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520			\|a Abstract The present study aims at formulation development and pharmacological evaluation of fixed dose combination of Bombyx mori (Abresham) extract, Flaxseed oil and coenzyme Q10 (CoQ10) against doxorubicin induced myocardial toxicity in rats. Formulation (emulsion) was prepared using dry gum method (continental method), by using pestle and mortar. The formulation was characterized by performing stability studies which includes flocculation and creaming, cracking, phase inversion and accelerated studies (temperature and light). In-vivo pharmacological evaluation of Bombyx mori coccon shell extract, Flaxseed oil, CoQ10 and its fixed dose combination (FDC) were then performed. Results obtained indicates that developed FDC and extract, Oil, CoQ10 passed all stability tests and significantly prevented drug induced increase in serum levels of AST, ALT, LDH, Creatinine and lipid profile (TC, LDL, VLDL and TG) and increases the levels of HDL and antioxidant parameters—SOD, GSH and CAT (in heart tissue). It also lowered the doxorubicin induced increase in heart weight due to hypertrophy. These results were also confirmed by histopathology. The results of this study strongly indicate the cardioprotective effect of fixed dose combination of BME, Flaxseed oil and CoQ10 against doxorubicin induced myocardial toxicity.
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650		4	\|a Doxorubicin \|7 (dpeaa)DE-He213
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700	1		\|a Khalid, Mohammad \|e verfasserin \|4 aut
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publishDate	2019
allfields	10.1007/s13596-019-00360-6 doi (DE-627)SPR031907040 (SPR)s13596-019-00360-6-e DE-627 ger DE-627 rakwb eng 610 ASE Tarique, Mohammad verfasserin aut Formulation development and pharmacological evaluation of fixed dose combination of Bombyx mori coccon shell extract, Flaxseed oil and coenzyme Q10 against doxorubicin induced cardiomyopathy in rats 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The present study aims at formulation development and pharmacological evaluation of fixed dose combination of Bombyx mori (Abresham) extract, Flaxseed oil and coenzyme Q10 (CoQ10) against doxorubicin induced myocardial toxicity in rats. Formulation (emulsion) was prepared using dry gum method (continental method), by using pestle and mortar. The formulation was characterized by performing stability studies which includes flocculation and creaming, cracking, phase inversion and accelerated studies (temperature and light). In-vivo pharmacological evaluation of Bombyx mori coccon shell extract, Flaxseed oil, CoQ10 and its fixed dose combination (FDC) were then performed. Results obtained indicates that developed FDC and extract, Oil, CoQ10 passed all stability tests and significantly prevented drug induced increase in serum levels of AST, ALT, LDH, Creatinine and lipid profile (TC, LDL, VLDL and TG) and increases the levels of HDL and antioxidant parameters—SOD, GSH and CAT (in heart tissue). It also lowered the doxorubicin induced increase in heart weight due to hypertrophy. These results were also confirmed by histopathology. The results of this study strongly indicate the cardioprotective effect of fixed dose combination of BME, Flaxseed oil and CoQ10 against doxorubicin induced myocardial toxicity. Coenzyme Q10 (dpeaa)DE-He213 Doxorubicin (dpeaa)DE-He213 Flaxseed oil (dpeaa)DE-He213 Myocardial infarction (dpeaa)DE-He213 Cardiomyopathy (dpeaa)DE-He213 Ahsan, Farogh verfasserin aut Akhtar, Juber verfasserin aut Khan, Mohammad Irfan verfasserin aut Khalid, Mohammad verfasserin aut Enthalten in Oriental pharmacy and experimental medicine Dordrecht : Springer, 2011 19(2019), 4 vom: 16. März, Seite 469-483 (DE-627)689127340 (DE-600)2655275-9 2211-1069 nnns volume:19 year:2019 number:4 day:16 month:03 pages:469-483 https://dx.doi.org/10.1007/s13596-019-00360-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 19 2019 4 16 03 469-483
spelling	10.1007/s13596-019-00360-6 doi (DE-627)SPR031907040 (SPR)s13596-019-00360-6-e DE-627 ger DE-627 rakwb eng 610 ASE Tarique, Mohammad verfasserin aut Formulation development and pharmacological evaluation of fixed dose combination of Bombyx mori coccon shell extract, Flaxseed oil and coenzyme Q10 against doxorubicin induced cardiomyopathy in rats 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The present study aims at formulation development and pharmacological evaluation of fixed dose combination of Bombyx mori (Abresham) extract, Flaxseed oil and coenzyme Q10 (CoQ10) against doxorubicin induced myocardial toxicity in rats. Formulation (emulsion) was prepared using dry gum method (continental method), by using pestle and mortar. The formulation was characterized by performing stability studies which includes flocculation and creaming, cracking, phase inversion and accelerated studies (temperature and light). In-vivo pharmacological evaluation of Bombyx mori coccon shell extract, Flaxseed oil, CoQ10 and its fixed dose combination (FDC) were then performed. Results obtained indicates that developed FDC and extract, Oil, CoQ10 passed all stability tests and significantly prevented drug induced increase in serum levels of AST, ALT, LDH, Creatinine and lipid profile (TC, LDL, VLDL and TG) and increases the levels of HDL and antioxidant parameters—SOD, GSH and CAT (in heart tissue). It also lowered the doxorubicin induced increase in heart weight due to hypertrophy. These results were also confirmed by histopathology. The results of this study strongly indicate the cardioprotective effect of fixed dose combination of BME, Flaxseed oil and CoQ10 against doxorubicin induced myocardial toxicity. Coenzyme Q10 (dpeaa)DE-He213 Doxorubicin (dpeaa)DE-He213 Flaxseed oil (dpeaa)DE-He213 Myocardial infarction (dpeaa)DE-He213 Cardiomyopathy (dpeaa)DE-He213 Ahsan, Farogh verfasserin aut Akhtar, Juber verfasserin aut Khan, Mohammad Irfan verfasserin aut Khalid, Mohammad verfasserin aut Enthalten in Oriental pharmacy and experimental medicine Dordrecht : Springer, 2011 19(2019), 4 vom: 16. März, Seite 469-483 (DE-627)689127340 (DE-600)2655275-9 2211-1069 nnns volume:19 year:2019 number:4 day:16 month:03 pages:469-483 https://dx.doi.org/10.1007/s13596-019-00360-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 19 2019 4 16 03 469-483
allfields_unstemmed	10.1007/s13596-019-00360-6 doi (DE-627)SPR031907040 (SPR)s13596-019-00360-6-e DE-627 ger DE-627 rakwb eng 610 ASE Tarique, Mohammad verfasserin aut Formulation development and pharmacological evaluation of fixed dose combination of Bombyx mori coccon shell extract, Flaxseed oil and coenzyme Q10 against doxorubicin induced cardiomyopathy in rats 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The present study aims at formulation development and pharmacological evaluation of fixed dose combination of Bombyx mori (Abresham) extract, Flaxseed oil and coenzyme Q10 (CoQ10) against doxorubicin induced myocardial toxicity in rats. Formulation (emulsion) was prepared using dry gum method (continental method), by using pestle and mortar. The formulation was characterized by performing stability studies which includes flocculation and creaming, cracking, phase inversion and accelerated studies (temperature and light). In-vivo pharmacological evaluation of Bombyx mori coccon shell extract, Flaxseed oil, CoQ10 and its fixed dose combination (FDC) were then performed. Results obtained indicates that developed FDC and extract, Oil, CoQ10 passed all stability tests and significantly prevented drug induced increase in serum levels of AST, ALT, LDH, Creatinine and lipid profile (TC, LDL, VLDL and TG) and increases the levels of HDL and antioxidant parameters—SOD, GSH and CAT (in heart tissue). It also lowered the doxorubicin induced increase in heart weight due to hypertrophy. These results were also confirmed by histopathology. The results of this study strongly indicate the cardioprotective effect of fixed dose combination of BME, Flaxseed oil and CoQ10 against doxorubicin induced myocardial toxicity. Coenzyme Q10 (dpeaa)DE-He213 Doxorubicin (dpeaa)DE-He213 Flaxseed oil (dpeaa)DE-He213 Myocardial infarction (dpeaa)DE-He213 Cardiomyopathy (dpeaa)DE-He213 Ahsan, Farogh verfasserin aut Akhtar, Juber verfasserin aut Khan, Mohammad Irfan verfasserin aut Khalid, Mohammad verfasserin aut Enthalten in Oriental pharmacy and experimental medicine Dordrecht : Springer, 2011 19(2019), 4 vom: 16. März, Seite 469-483 (DE-627)689127340 (DE-600)2655275-9 2211-1069 nnns volume:19 year:2019 number:4 day:16 month:03 pages:469-483 https://dx.doi.org/10.1007/s13596-019-00360-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 19 2019 4 16 03 469-483
allfieldsGer	10.1007/s13596-019-00360-6 doi (DE-627)SPR031907040 (SPR)s13596-019-00360-6-e DE-627 ger DE-627 rakwb eng 610 ASE Tarique, Mohammad verfasserin aut Formulation development and pharmacological evaluation of fixed dose combination of Bombyx mori coccon shell extract, Flaxseed oil and coenzyme Q10 against doxorubicin induced cardiomyopathy in rats 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The present study aims at formulation development and pharmacological evaluation of fixed dose combination of Bombyx mori (Abresham) extract, Flaxseed oil and coenzyme Q10 (CoQ10) against doxorubicin induced myocardial toxicity in rats. Formulation (emulsion) was prepared using dry gum method (continental method), by using pestle and mortar. The formulation was characterized by performing stability studies which includes flocculation and creaming, cracking, phase inversion and accelerated studies (temperature and light). In-vivo pharmacological evaluation of Bombyx mori coccon shell extract, Flaxseed oil, CoQ10 and its fixed dose combination (FDC) were then performed. Results obtained indicates that developed FDC and extract, Oil, CoQ10 passed all stability tests and significantly prevented drug induced increase in serum levels of AST, ALT, LDH, Creatinine and lipid profile (TC, LDL, VLDL and TG) and increases the levels of HDL and antioxidant parameters—SOD, GSH and CAT (in heart tissue). It also lowered the doxorubicin induced increase in heart weight due to hypertrophy. These results were also confirmed by histopathology. The results of this study strongly indicate the cardioprotective effect of fixed dose combination of BME, Flaxseed oil and CoQ10 against doxorubicin induced myocardial toxicity. Coenzyme Q10 (dpeaa)DE-He213 Doxorubicin (dpeaa)DE-He213 Flaxseed oil (dpeaa)DE-He213 Myocardial infarction (dpeaa)DE-He213 Cardiomyopathy (dpeaa)DE-He213 Ahsan, Farogh verfasserin aut Akhtar, Juber verfasserin aut Khan, Mohammad Irfan verfasserin aut Khalid, Mohammad verfasserin aut Enthalten in Oriental pharmacy and experimental medicine Dordrecht : Springer, 2011 19(2019), 4 vom: 16. März, Seite 469-483 (DE-627)689127340 (DE-600)2655275-9 2211-1069 nnns volume:19 year:2019 number:4 day:16 month:03 pages:469-483 https://dx.doi.org/10.1007/s13596-019-00360-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 19 2019 4 16 03 469-483
allfieldsSound	10.1007/s13596-019-00360-6 doi (DE-627)SPR031907040 (SPR)s13596-019-00360-6-e DE-627 ger DE-627 rakwb eng 610 ASE Tarique, Mohammad verfasserin aut Formulation development and pharmacological evaluation of fixed dose combination of Bombyx mori coccon shell extract, Flaxseed oil and coenzyme Q10 against doxorubicin induced cardiomyopathy in rats 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The present study aims at formulation development and pharmacological evaluation of fixed dose combination of Bombyx mori (Abresham) extract, Flaxseed oil and coenzyme Q10 (CoQ10) against doxorubicin induced myocardial toxicity in rats. Formulation (emulsion) was prepared using dry gum method (continental method), by using pestle and mortar. The formulation was characterized by performing stability studies which includes flocculation and creaming, cracking, phase inversion and accelerated studies (temperature and light). In-vivo pharmacological evaluation of Bombyx mori coccon shell extract, Flaxseed oil, CoQ10 and its fixed dose combination (FDC) were then performed. Results obtained indicates that developed FDC and extract, Oil, CoQ10 passed all stability tests and significantly prevented drug induced increase in serum levels of AST, ALT, LDH, Creatinine and lipid profile (TC, LDL, VLDL and TG) and increases the levels of HDL and antioxidant parameters—SOD, GSH and CAT (in heart tissue). It also lowered the doxorubicin induced increase in heart weight due to hypertrophy. These results were also confirmed by histopathology. The results of this study strongly indicate the cardioprotective effect of fixed dose combination of BME, Flaxseed oil and CoQ10 against doxorubicin induced myocardial toxicity. Coenzyme Q10 (dpeaa)DE-He213 Doxorubicin (dpeaa)DE-He213 Flaxseed oil (dpeaa)DE-He213 Myocardial infarction (dpeaa)DE-He213 Cardiomyopathy (dpeaa)DE-He213 Ahsan, Farogh verfasserin aut Akhtar, Juber verfasserin aut Khan, Mohammad Irfan verfasserin aut Khalid, Mohammad verfasserin aut Enthalten in Oriental pharmacy and experimental medicine Dordrecht : Springer, 2011 19(2019), 4 vom: 16. März, Seite 469-483 (DE-627)689127340 (DE-600)2655275-9 2211-1069 nnns volume:19 year:2019 number:4 day:16 month:03 pages:469-483 https://dx.doi.org/10.1007/s13596-019-00360-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 19 2019 4 16 03 469-483
language	English
source	Enthalten in Oriental pharmacy and experimental medicine 19(2019), 4 vom: 16. März, Seite 469-483 volume:19 year:2019 number:4 day:16 month:03 pages:469-483
sourceStr	Enthalten in Oriental pharmacy and experimental medicine 19(2019), 4 vom: 16. März, Seite 469-483 volume:19 year:2019 number:4 day:16 month:03 pages:469-483
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Coenzyme Q10 Doxorubicin Flaxseed oil Myocardial infarction Cardiomyopathy
dewey-raw	610
isfreeaccess_bool	false
container_title	Oriental pharmacy and experimental medicine
authorswithroles_txt_mv	Tarique, Mohammad @@aut@@ Ahsan, Farogh @@aut@@ Akhtar, Juber @@aut@@ Khan, Mohammad Irfan @@aut@@ Khalid, Mohammad @@aut@@
publishDateDaySort_date	2019-03-16T00:00:00Z
hierarchy_top_id	689127340
dewey-sort	3610
id	SPR031907040
language_de	englisch
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author	Tarique, Mohammad
spellingShingle	Tarique, Mohammad ddc 610 misc Coenzyme Q10 misc Doxorubicin misc Flaxseed oil misc Myocardial infarction misc Cardiomyopathy Formulation development and pharmacological evaluation of fixed dose combination of Bombyx mori coccon shell extract, Flaxseed oil and coenzyme Q10 against doxorubicin induced cardiomyopathy in rats
authorStr	Tarique, Mohammad
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topic_title	610 ASE Formulation development and pharmacological evaluation of fixed dose combination of Bombyx mori coccon shell extract, Flaxseed oil and coenzyme Q10 against doxorubicin induced cardiomyopathy in rats Coenzyme Q10 (dpeaa)DE-He213 Doxorubicin (dpeaa)DE-He213 Flaxseed oil (dpeaa)DE-He213 Myocardial infarction (dpeaa)DE-He213 Cardiomyopathy (dpeaa)DE-He213
topic	ddc 610 misc Coenzyme Q10 misc Doxorubicin misc Flaxseed oil misc Myocardial infarction misc Cardiomyopathy
topic_unstemmed	ddc 610 misc Coenzyme Q10 misc Doxorubicin misc Flaxseed oil misc Myocardial infarction misc Cardiomyopathy
topic_browse	ddc 610 misc Coenzyme Q10 misc Doxorubicin misc Flaxseed oil misc Myocardial infarction misc Cardiomyopathy
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title	Formulation development and pharmacological evaluation of fixed dose combination of Bombyx mori coccon shell extract, Flaxseed oil and coenzyme Q10 against doxorubicin induced cardiomyopathy in rats
ctrlnum	(DE-627)SPR031907040 (SPR)s13596-019-00360-6-e
title_full	Formulation development and pharmacological evaluation of fixed dose combination of Bombyx mori coccon shell extract, Flaxseed oil and coenzyme Q10 against doxorubicin induced cardiomyopathy in rats
author_sort	Tarique, Mohammad
journal	Oriental pharmacy and experimental medicine
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author_browse	Tarique, Mohammad Ahsan, Farogh Akhtar, Juber Khan, Mohammad Irfan Khalid, Mohammad
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title_sort	formulation development and pharmacological evaluation of fixed dose combination of bombyx mori coccon shell extract, flaxseed oil and coenzyme q10 against doxorubicin induced cardiomyopathy in rats
title_auth	Formulation development and pharmacological evaluation of fixed dose combination of Bombyx mori coccon shell extract, Flaxseed oil and coenzyme Q10 against doxorubicin induced cardiomyopathy in rats
abstract	Abstract The present study aims at formulation development and pharmacological evaluation of fixed dose combination of Bombyx mori (Abresham) extract, Flaxseed oil and coenzyme Q10 (CoQ10) against doxorubicin induced myocardial toxicity in rats. Formulation (emulsion) was prepared using dry gum method (continental method), by using pestle and mortar. The formulation was characterized by performing stability studies which includes flocculation and creaming, cracking, phase inversion and accelerated studies (temperature and light). In-vivo pharmacological evaluation of Bombyx mori coccon shell extract, Flaxseed oil, CoQ10 and its fixed dose combination (FDC) were then performed. Results obtained indicates that developed FDC and extract, Oil, CoQ10 passed all stability tests and significantly prevented drug induced increase in serum levels of AST, ALT, LDH, Creatinine and lipid profile (TC, LDL, VLDL and TG) and increases the levels of HDL and antioxidant parameters—SOD, GSH and CAT (in heart tissue). It also lowered the doxorubicin induced increase in heart weight due to hypertrophy. These results were also confirmed by histopathology. The results of this study strongly indicate the cardioprotective effect of fixed dose combination of BME, Flaxseed oil and CoQ10 against doxorubicin induced myocardial toxicity.
abstractGer	Abstract The present study aims at formulation development and pharmacological evaluation of fixed dose combination of Bombyx mori (Abresham) extract, Flaxseed oil and coenzyme Q10 (CoQ10) against doxorubicin induced myocardial toxicity in rats. Formulation (emulsion) was prepared using dry gum method (continental method), by using pestle and mortar. The formulation was characterized by performing stability studies which includes flocculation and creaming, cracking, phase inversion and accelerated studies (temperature and light). In-vivo pharmacological evaluation of Bombyx mori coccon shell extract, Flaxseed oil, CoQ10 and its fixed dose combination (FDC) were then performed. Results obtained indicates that developed FDC and extract, Oil, CoQ10 passed all stability tests and significantly prevented drug induced increase in serum levels of AST, ALT, LDH, Creatinine and lipid profile (TC, LDL, VLDL and TG) and increases the levels of HDL and antioxidant parameters—SOD, GSH and CAT (in heart tissue). It also lowered the doxorubicin induced increase in heart weight due to hypertrophy. These results were also confirmed by histopathology. The results of this study strongly indicate the cardioprotective effect of fixed dose combination of BME, Flaxseed oil and CoQ10 against doxorubicin induced myocardial toxicity.
abstract_unstemmed	Abstract The present study aims at formulation development and pharmacological evaluation of fixed dose combination of Bombyx mori (Abresham) extract, Flaxseed oil and coenzyme Q10 (CoQ10) against doxorubicin induced myocardial toxicity in rats. Formulation (emulsion) was prepared using dry gum method (continental method), by using pestle and mortar. The formulation was characterized by performing stability studies which includes flocculation and creaming, cracking, phase inversion and accelerated studies (temperature and light). In-vivo pharmacological evaluation of Bombyx mori coccon shell extract, Flaxseed oil, CoQ10 and its fixed dose combination (FDC) were then performed. Results obtained indicates that developed FDC and extract, Oil, CoQ10 passed all stability tests and significantly prevented drug induced increase in serum levels of AST, ALT, LDH, Creatinine and lipid profile (TC, LDL, VLDL and TG) and increases the levels of HDL and antioxidant parameters—SOD, GSH and CAT (in heart tissue). It also lowered the doxorubicin induced increase in heart weight due to hypertrophy. These results were also confirmed by histopathology. The results of this study strongly indicate the cardioprotective effect of fixed dose combination of BME, Flaxseed oil and CoQ10 against doxorubicin induced myocardial toxicity.
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title_short	Formulation development and pharmacological evaluation of fixed dose combination of Bombyx mori coccon shell extract, Flaxseed oil and coenzyme Q10 against doxorubicin induced cardiomyopathy in rats
url	https://dx.doi.org/10.1007/s13596-019-00360-6
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author2	Ahsan, Farogh Akhtar, Juber Khan, Mohammad Irfan Khalid, Mohammad
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up_date	2024-07-04T01:46:48.038Z
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Formulation (emulsion) was prepared using dry gum method (continental method), by using pestle and mortar. The formulation was characterized by performing stability studies which includes flocculation and creaming, cracking, phase inversion and accelerated studies (temperature and light). In-vivo pharmacological evaluation of Bombyx mori coccon shell extract, Flaxseed oil, CoQ10 and its fixed dose combination (FDC) were then performed. Results obtained indicates that developed FDC and extract, Oil, CoQ10 passed all stability tests and significantly prevented drug induced increase in serum levels of AST, ALT, LDH, Creatinine and lipid profile (TC, LDL, VLDL and TG) and increases the levels of HDL and antioxidant parameters—SOD, GSH and CAT (in heart tissue). It also lowered the doxorubicin induced increase in heart weight due to hypertrophy. These results were also confirmed by histopathology. 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Formulation development and pharmacological evaluation of fixed dose combination of Bombyx mori coccon shell extract, Flaxseed oil and coenzyme Q10 against doxorubicin induced cardiomyopathy in rats

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