High-dose intravenous immunoglobulin therapy for eosinophilic granulomatosis with polyangiitis
Background Regulatory T ($ T_{reg} $) cells are implicated in the development and progression of eosinophilic granulomatosis with polyangiitis (EGPA). We previously showed beneficial effects of intravenous immunoglobulin (IVIG) therapy combined with corticosteroid and immunosuppressant treatment on...
Ausführliche Beschreibung
Autor*in: |
Tsurikisawa, Naomi [verfasserIn] Saito, Hiroshi [verfasserIn] Oshikata, Chiyako [verfasserIn] Tsuburai, Takahiro [verfasserIn] Akiyama, Kazuo [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2014 |
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Übergeordnetes Werk: |
Enthalten in: Clinical and translational allergy - Hoboken, NJ : Wiley, 2011, 4(2014), 1 vom: 12. Dez. |
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Übergeordnetes Werk: |
volume:4 ; year:2014 ; number:1 ; day:12 ; month:12 |
Links: |
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DOI / URN: |
10.1186/2045-7022-4-38 |
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Katalog-ID: |
SPR031914748 |
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520 | |a Background Regulatory T ($ T_{reg} $) cells are implicated in the development and progression of eosinophilic granulomatosis with polyangiitis (EGPA). We previously showed beneficial effects of intravenous immunoglobulin (IVIG) therapy combined with corticosteroid and immunosuppressant treatment on clinical symptoms, including mononeuritis multiplex and cardiac dysfunction, and $ T_{reg} $ cell frequency, during EGPA. Whether the timing of administration (during initial treatment or at relapse after remission) or previous treatment affects the clinical and immunologic efficacy of IVIG is unknown. We evaluated whether the frequency of $ T_{reg} $ cells varied depending on when IVIG was provided relative to the start of conventional therapy for EGPA. Methods The patient population for this retrospective analysis comprised 17 patients with severe mononeuritis multiplex or heart failure whose EGPA did not respond to corticosteroids combined with immunosuppressant therapy. Ten patients first received IVIG during initial treatment, whereas the remaining 7 patients first received IVIG on relapse after remission. We measured the percentage of $ T_{reg} $ cells, defined as $ FOXP3^{+} %$ CD4^{+} $ T cells, present before the first round of IVIG and at 1 month after the last IVIG treatment. Results $ FOXP3^{+} %$ CD4^{+} $ T cells were increased in patients who required only a single course of IVIG to achieve remission compared with those who needed two or more courses. The dosage of prednisolone at initial IVIG was inversely correlated with the ratio of the number of $ FOXP3^{+} %$ CD4^{+} $ T cells before IVIG and that at 1 month thereafter. Conclusion Patients with severe EGPA who receive IVIG after nonresponse to high-dose prednisolone during initial treatment may need multiple courses of IVIG to achieve remission. An increase in the frequency of $ T_{reg} $ cells after IVIG may predict the need for additional IVIG in EGPA. | ||
650 | 4 | |a Eosinophilic granulomatosis with polyangiitis |7 (dpeaa)DE-He213 | |
650 | 4 | |a Churg–Strauss syndrome |7 (dpeaa)DE-He213 | |
650 | 4 | |a Intravenous immunoglobulin |7 (dpeaa)DE-He213 | |
650 | 4 | |a Regulatory T cells |7 (dpeaa)DE-He213 | |
650 | 4 | |a IgG |7 (dpeaa)DE-He213 | |
700 | 1 | |a Saito, Hiroshi |e verfasserin |4 aut | |
700 | 1 | |a Oshikata, Chiyako |e verfasserin |4 aut | |
700 | 1 | |a Tsuburai, Takahiro |e verfasserin |4 aut | |
700 | 1 | |a Akiyama, Kazuo |e verfasserin |4 aut | |
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10.1186/2045-7022-4-38 doi (DE-627)SPR031914748 (SPR)2045-7022-4-38-e DE-627 ger DE-627 rakwb eng 610 ASE Tsurikisawa, Naomi verfasserin aut High-dose intravenous immunoglobulin therapy for eosinophilic granulomatosis with polyangiitis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Regulatory T ($ T_{reg} $) cells are implicated in the development and progression of eosinophilic granulomatosis with polyangiitis (EGPA). We previously showed beneficial effects of intravenous immunoglobulin (IVIG) therapy combined with corticosteroid and immunosuppressant treatment on clinical symptoms, including mononeuritis multiplex and cardiac dysfunction, and $ T_{reg} $ cell frequency, during EGPA. Whether the timing of administration (during initial treatment or at relapse after remission) or previous treatment affects the clinical and immunologic efficacy of IVIG is unknown. We evaluated whether the frequency of $ T_{reg} $ cells varied depending on when IVIG was provided relative to the start of conventional therapy for EGPA. Methods The patient population for this retrospective analysis comprised 17 patients with severe mononeuritis multiplex or heart failure whose EGPA did not respond to corticosteroids combined with immunosuppressant therapy. Ten patients first received IVIG during initial treatment, whereas the remaining 7 patients first received IVIG on relapse after remission. We measured the percentage of $ T_{reg} $ cells, defined as $ FOXP3^{+} %$ CD4^{+} $ T cells, present before the first round of IVIG and at 1 month after the last IVIG treatment. Results $ FOXP3^{+} %$ CD4^{+} $ T cells were increased in patients who required only a single course of IVIG to achieve remission compared with those who needed two or more courses. The dosage of prednisolone at initial IVIG was inversely correlated with the ratio of the number of $ FOXP3^{+} %$ CD4^{+} $ T cells before IVIG and that at 1 month thereafter. Conclusion Patients with severe EGPA who receive IVIG after nonresponse to high-dose prednisolone during initial treatment may need multiple courses of IVIG to achieve remission. An increase in the frequency of $ T_{reg} $ cells after IVIG may predict the need for additional IVIG in EGPA. Eosinophilic granulomatosis with polyangiitis (dpeaa)DE-He213 Churg–Strauss syndrome (dpeaa)DE-He213 Intravenous immunoglobulin (dpeaa)DE-He213 Regulatory T cells (dpeaa)DE-He213 IgG (dpeaa)DE-He213 Saito, Hiroshi verfasserin aut Oshikata, Chiyako verfasserin aut Tsuburai, Takahiro verfasserin aut Akiyama, Kazuo verfasserin aut Enthalten in Clinical and translational allergy Hoboken, NJ : Wiley, 2011 4(2014), 1 vom: 12. Dez. (DE-627)669883573 (DE-600)2630865-4 2045-7022 nnns volume:4 year:2014 number:1 day:12 month:12 https://dx.doi.org/10.1186/2045-7022-4-38 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2014 1 12 12 |
spelling |
10.1186/2045-7022-4-38 doi (DE-627)SPR031914748 (SPR)2045-7022-4-38-e DE-627 ger DE-627 rakwb eng 610 ASE Tsurikisawa, Naomi verfasserin aut High-dose intravenous immunoglobulin therapy for eosinophilic granulomatosis with polyangiitis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Regulatory T ($ T_{reg} $) cells are implicated in the development and progression of eosinophilic granulomatosis with polyangiitis (EGPA). We previously showed beneficial effects of intravenous immunoglobulin (IVIG) therapy combined with corticosteroid and immunosuppressant treatment on clinical symptoms, including mononeuritis multiplex and cardiac dysfunction, and $ T_{reg} $ cell frequency, during EGPA. Whether the timing of administration (during initial treatment or at relapse after remission) or previous treatment affects the clinical and immunologic efficacy of IVIG is unknown. We evaluated whether the frequency of $ T_{reg} $ cells varied depending on when IVIG was provided relative to the start of conventional therapy for EGPA. Methods The patient population for this retrospective analysis comprised 17 patients with severe mononeuritis multiplex or heart failure whose EGPA did not respond to corticosteroids combined with immunosuppressant therapy. Ten patients first received IVIG during initial treatment, whereas the remaining 7 patients first received IVIG on relapse after remission. We measured the percentage of $ T_{reg} $ cells, defined as $ FOXP3^{+} %$ CD4^{+} $ T cells, present before the first round of IVIG and at 1 month after the last IVIG treatment. Results $ FOXP3^{+} %$ CD4^{+} $ T cells were increased in patients who required only a single course of IVIG to achieve remission compared with those who needed two or more courses. The dosage of prednisolone at initial IVIG was inversely correlated with the ratio of the number of $ FOXP3^{+} %$ CD4^{+} $ T cells before IVIG and that at 1 month thereafter. Conclusion Patients with severe EGPA who receive IVIG after nonresponse to high-dose prednisolone during initial treatment may need multiple courses of IVIG to achieve remission. An increase in the frequency of $ T_{reg} $ cells after IVIG may predict the need for additional IVIG in EGPA. Eosinophilic granulomatosis with polyangiitis (dpeaa)DE-He213 Churg–Strauss syndrome (dpeaa)DE-He213 Intravenous immunoglobulin (dpeaa)DE-He213 Regulatory T cells (dpeaa)DE-He213 IgG (dpeaa)DE-He213 Saito, Hiroshi verfasserin aut Oshikata, Chiyako verfasserin aut Tsuburai, Takahiro verfasserin aut Akiyama, Kazuo verfasserin aut Enthalten in Clinical and translational allergy Hoboken, NJ : Wiley, 2011 4(2014), 1 vom: 12. Dez. (DE-627)669883573 (DE-600)2630865-4 2045-7022 nnns volume:4 year:2014 number:1 day:12 month:12 https://dx.doi.org/10.1186/2045-7022-4-38 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2014 1 12 12 |
allfields_unstemmed |
10.1186/2045-7022-4-38 doi (DE-627)SPR031914748 (SPR)2045-7022-4-38-e DE-627 ger DE-627 rakwb eng 610 ASE Tsurikisawa, Naomi verfasserin aut High-dose intravenous immunoglobulin therapy for eosinophilic granulomatosis with polyangiitis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Regulatory T ($ T_{reg} $) cells are implicated in the development and progression of eosinophilic granulomatosis with polyangiitis (EGPA). We previously showed beneficial effects of intravenous immunoglobulin (IVIG) therapy combined with corticosteroid and immunosuppressant treatment on clinical symptoms, including mononeuritis multiplex and cardiac dysfunction, and $ T_{reg} $ cell frequency, during EGPA. Whether the timing of administration (during initial treatment or at relapse after remission) or previous treatment affects the clinical and immunologic efficacy of IVIG is unknown. We evaluated whether the frequency of $ T_{reg} $ cells varied depending on when IVIG was provided relative to the start of conventional therapy for EGPA. Methods The patient population for this retrospective analysis comprised 17 patients with severe mononeuritis multiplex or heart failure whose EGPA did not respond to corticosteroids combined with immunosuppressant therapy. Ten patients first received IVIG during initial treatment, whereas the remaining 7 patients first received IVIG on relapse after remission. We measured the percentage of $ T_{reg} $ cells, defined as $ FOXP3^{+} %$ CD4^{+} $ T cells, present before the first round of IVIG and at 1 month after the last IVIG treatment. Results $ FOXP3^{+} %$ CD4^{+} $ T cells were increased in patients who required only a single course of IVIG to achieve remission compared with those who needed two or more courses. The dosage of prednisolone at initial IVIG was inversely correlated with the ratio of the number of $ FOXP3^{+} %$ CD4^{+} $ T cells before IVIG and that at 1 month thereafter. Conclusion Patients with severe EGPA who receive IVIG after nonresponse to high-dose prednisolone during initial treatment may need multiple courses of IVIG to achieve remission. An increase in the frequency of $ T_{reg} $ cells after IVIG may predict the need for additional IVIG in EGPA. Eosinophilic granulomatosis with polyangiitis (dpeaa)DE-He213 Churg–Strauss syndrome (dpeaa)DE-He213 Intravenous immunoglobulin (dpeaa)DE-He213 Regulatory T cells (dpeaa)DE-He213 IgG (dpeaa)DE-He213 Saito, Hiroshi verfasserin aut Oshikata, Chiyako verfasserin aut Tsuburai, Takahiro verfasserin aut Akiyama, Kazuo verfasserin aut Enthalten in Clinical and translational allergy Hoboken, NJ : Wiley, 2011 4(2014), 1 vom: 12. Dez. (DE-627)669883573 (DE-600)2630865-4 2045-7022 nnns volume:4 year:2014 number:1 day:12 month:12 https://dx.doi.org/10.1186/2045-7022-4-38 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2014 1 12 12 |
allfieldsGer |
10.1186/2045-7022-4-38 doi (DE-627)SPR031914748 (SPR)2045-7022-4-38-e DE-627 ger DE-627 rakwb eng 610 ASE Tsurikisawa, Naomi verfasserin aut High-dose intravenous immunoglobulin therapy for eosinophilic granulomatosis with polyangiitis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Regulatory T ($ T_{reg} $) cells are implicated in the development and progression of eosinophilic granulomatosis with polyangiitis (EGPA). We previously showed beneficial effects of intravenous immunoglobulin (IVIG) therapy combined with corticosteroid and immunosuppressant treatment on clinical symptoms, including mononeuritis multiplex and cardiac dysfunction, and $ T_{reg} $ cell frequency, during EGPA. Whether the timing of administration (during initial treatment or at relapse after remission) or previous treatment affects the clinical and immunologic efficacy of IVIG is unknown. We evaluated whether the frequency of $ T_{reg} $ cells varied depending on when IVIG was provided relative to the start of conventional therapy for EGPA. Methods The patient population for this retrospective analysis comprised 17 patients with severe mononeuritis multiplex or heart failure whose EGPA did not respond to corticosteroids combined with immunosuppressant therapy. Ten patients first received IVIG during initial treatment, whereas the remaining 7 patients first received IVIG on relapse after remission. We measured the percentage of $ T_{reg} $ cells, defined as $ FOXP3^{+} %$ CD4^{+} $ T cells, present before the first round of IVIG and at 1 month after the last IVIG treatment. Results $ FOXP3^{+} %$ CD4^{+} $ T cells were increased in patients who required only a single course of IVIG to achieve remission compared with those who needed two or more courses. The dosage of prednisolone at initial IVIG was inversely correlated with the ratio of the number of $ FOXP3^{+} %$ CD4^{+} $ T cells before IVIG and that at 1 month thereafter. Conclusion Patients with severe EGPA who receive IVIG after nonresponse to high-dose prednisolone during initial treatment may need multiple courses of IVIG to achieve remission. An increase in the frequency of $ T_{reg} $ cells after IVIG may predict the need for additional IVIG in EGPA. Eosinophilic granulomatosis with polyangiitis (dpeaa)DE-He213 Churg–Strauss syndrome (dpeaa)DE-He213 Intravenous immunoglobulin (dpeaa)DE-He213 Regulatory T cells (dpeaa)DE-He213 IgG (dpeaa)DE-He213 Saito, Hiroshi verfasserin aut Oshikata, Chiyako verfasserin aut Tsuburai, Takahiro verfasserin aut Akiyama, Kazuo verfasserin aut Enthalten in Clinical and translational allergy Hoboken, NJ : Wiley, 2011 4(2014), 1 vom: 12. Dez. (DE-627)669883573 (DE-600)2630865-4 2045-7022 nnns volume:4 year:2014 number:1 day:12 month:12 https://dx.doi.org/10.1186/2045-7022-4-38 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2014 1 12 12 |
allfieldsSound |
10.1186/2045-7022-4-38 doi (DE-627)SPR031914748 (SPR)2045-7022-4-38-e DE-627 ger DE-627 rakwb eng 610 ASE Tsurikisawa, Naomi verfasserin aut High-dose intravenous immunoglobulin therapy for eosinophilic granulomatosis with polyangiitis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Regulatory T ($ T_{reg} $) cells are implicated in the development and progression of eosinophilic granulomatosis with polyangiitis (EGPA). We previously showed beneficial effects of intravenous immunoglobulin (IVIG) therapy combined with corticosteroid and immunosuppressant treatment on clinical symptoms, including mononeuritis multiplex and cardiac dysfunction, and $ T_{reg} $ cell frequency, during EGPA. Whether the timing of administration (during initial treatment or at relapse after remission) or previous treatment affects the clinical and immunologic efficacy of IVIG is unknown. We evaluated whether the frequency of $ T_{reg} $ cells varied depending on when IVIG was provided relative to the start of conventional therapy for EGPA. Methods The patient population for this retrospective analysis comprised 17 patients with severe mononeuritis multiplex or heart failure whose EGPA did not respond to corticosteroids combined with immunosuppressant therapy. Ten patients first received IVIG during initial treatment, whereas the remaining 7 patients first received IVIG on relapse after remission. We measured the percentage of $ T_{reg} $ cells, defined as $ FOXP3^{+} %$ CD4^{+} $ T cells, present before the first round of IVIG and at 1 month after the last IVIG treatment. Results $ FOXP3^{+} %$ CD4^{+} $ T cells were increased in patients who required only a single course of IVIG to achieve remission compared with those who needed two or more courses. The dosage of prednisolone at initial IVIG was inversely correlated with the ratio of the number of $ FOXP3^{+} %$ CD4^{+} $ T cells before IVIG and that at 1 month thereafter. Conclusion Patients with severe EGPA who receive IVIG after nonresponse to high-dose prednisolone during initial treatment may need multiple courses of IVIG to achieve remission. An increase in the frequency of $ T_{reg} $ cells after IVIG may predict the need for additional IVIG in EGPA. Eosinophilic granulomatosis with polyangiitis (dpeaa)DE-He213 Churg–Strauss syndrome (dpeaa)DE-He213 Intravenous immunoglobulin (dpeaa)DE-He213 Regulatory T cells (dpeaa)DE-He213 IgG (dpeaa)DE-He213 Saito, Hiroshi verfasserin aut Oshikata, Chiyako verfasserin aut Tsuburai, Takahiro verfasserin aut Akiyama, Kazuo verfasserin aut Enthalten in Clinical and translational allergy Hoboken, NJ : Wiley, 2011 4(2014), 1 vom: 12. Dez. (DE-627)669883573 (DE-600)2630865-4 2045-7022 nnns volume:4 year:2014 number:1 day:12 month:12 https://dx.doi.org/10.1186/2045-7022-4-38 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2014 1 12 12 |
language |
English |
source |
Enthalten in Clinical and translational allergy 4(2014), 1 vom: 12. Dez. volume:4 year:2014 number:1 day:12 month:12 |
sourceStr |
Enthalten in Clinical and translational allergy 4(2014), 1 vom: 12. Dez. volume:4 year:2014 number:1 day:12 month:12 |
format_phy_str_mv |
Article |
institution |
findex.gbv.de |
topic_facet |
Eosinophilic granulomatosis with polyangiitis Churg–Strauss syndrome Intravenous immunoglobulin Regulatory T cells IgG |
dewey-raw |
610 |
isfreeaccess_bool |
true |
container_title |
Clinical and translational allergy |
authorswithroles_txt_mv |
Tsurikisawa, Naomi @@aut@@ Saito, Hiroshi @@aut@@ Oshikata, Chiyako @@aut@@ Tsuburai, Takahiro @@aut@@ Akiyama, Kazuo @@aut@@ |
publishDateDaySort_date |
2014-12-12T00:00:00Z |
hierarchy_top_id |
669883573 |
dewey-sort |
3610 |
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SPR031914748 |
language_de |
englisch |
fullrecord |
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We previously showed beneficial effects of intravenous immunoglobulin (IVIG) therapy combined with corticosteroid and immunosuppressant treatment on clinical symptoms, including mononeuritis multiplex and cardiac dysfunction, and $ T_{reg} $ cell frequency, during EGPA. Whether the timing of administration (during initial treatment or at relapse after remission) or previous treatment affects the clinical and immunologic efficacy of IVIG is unknown. We evaluated whether the frequency of $ T_{reg} $ cells varied depending on when IVIG was provided relative to the start of conventional therapy for EGPA. Methods The patient population for this retrospective analysis comprised 17 patients with severe mononeuritis multiplex or heart failure whose EGPA did not respond to corticosteroids combined with immunosuppressant therapy. Ten patients first received IVIG during initial treatment, whereas the remaining 7 patients first received IVIG on relapse after remission. We measured the percentage of $ T_{reg} $ cells, defined as $ FOXP3^{+} %$ CD4^{+} $ T cells, present before the first round of IVIG and at 1 month after the last IVIG treatment. Results $ FOXP3^{+} %$ CD4^{+} $ T cells were increased in patients who required only a single course of IVIG to achieve remission compared with those who needed two or more courses. The dosage of prednisolone at initial IVIG was inversely correlated with the ratio of the number of $ FOXP3^{+} %$ CD4^{+} $ T cells before IVIG and that at 1 month thereafter. Conclusion Patients with severe EGPA who receive IVIG after nonresponse to high-dose prednisolone during initial treatment may need multiple courses of IVIG to achieve remission. 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Tsurikisawa, Naomi |
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Tsurikisawa, Naomi ddc 610 misc Eosinophilic granulomatosis with polyangiitis misc Churg–Strauss syndrome misc Intravenous immunoglobulin misc Regulatory T cells misc IgG High-dose intravenous immunoglobulin therapy for eosinophilic granulomatosis with polyangiitis |
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610 ASE High-dose intravenous immunoglobulin therapy for eosinophilic granulomatosis with polyangiitis Eosinophilic granulomatosis with polyangiitis (dpeaa)DE-He213 Churg–Strauss syndrome (dpeaa)DE-He213 Intravenous immunoglobulin (dpeaa)DE-He213 Regulatory T cells (dpeaa)DE-He213 IgG (dpeaa)DE-He213 |
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ddc 610 misc Eosinophilic granulomatosis with polyangiitis misc Churg–Strauss syndrome misc Intravenous immunoglobulin misc Regulatory T cells misc IgG |
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High-dose intravenous immunoglobulin therapy for eosinophilic granulomatosis with polyangiitis |
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High-dose intravenous immunoglobulin therapy for eosinophilic granulomatosis with polyangiitis |
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Tsurikisawa, Naomi Saito, Hiroshi Oshikata, Chiyako Tsuburai, Takahiro Akiyama, Kazuo |
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high-dose intravenous immunoglobulin therapy for eosinophilic granulomatosis with polyangiitis |
title_auth |
High-dose intravenous immunoglobulin therapy for eosinophilic granulomatosis with polyangiitis |
abstract |
Background Regulatory T ($ T_{reg} $) cells are implicated in the development and progression of eosinophilic granulomatosis with polyangiitis (EGPA). We previously showed beneficial effects of intravenous immunoglobulin (IVIG) therapy combined with corticosteroid and immunosuppressant treatment on clinical symptoms, including mononeuritis multiplex and cardiac dysfunction, and $ T_{reg} $ cell frequency, during EGPA. Whether the timing of administration (during initial treatment or at relapse after remission) or previous treatment affects the clinical and immunologic efficacy of IVIG is unknown. We evaluated whether the frequency of $ T_{reg} $ cells varied depending on when IVIG was provided relative to the start of conventional therapy for EGPA. Methods The patient population for this retrospective analysis comprised 17 patients with severe mononeuritis multiplex or heart failure whose EGPA did not respond to corticosteroids combined with immunosuppressant therapy. Ten patients first received IVIG during initial treatment, whereas the remaining 7 patients first received IVIG on relapse after remission. We measured the percentage of $ T_{reg} $ cells, defined as $ FOXP3^{+} %$ CD4^{+} $ T cells, present before the first round of IVIG and at 1 month after the last IVIG treatment. Results $ FOXP3^{+} %$ CD4^{+} $ T cells were increased in patients who required only a single course of IVIG to achieve remission compared with those who needed two or more courses. The dosage of prednisolone at initial IVIG was inversely correlated with the ratio of the number of $ FOXP3^{+} %$ CD4^{+} $ T cells before IVIG and that at 1 month thereafter. Conclusion Patients with severe EGPA who receive IVIG after nonresponse to high-dose prednisolone during initial treatment may need multiple courses of IVIG to achieve remission. An increase in the frequency of $ T_{reg} $ cells after IVIG may predict the need for additional IVIG in EGPA. |
abstractGer |
Background Regulatory T ($ T_{reg} $) cells are implicated in the development and progression of eosinophilic granulomatosis with polyangiitis (EGPA). We previously showed beneficial effects of intravenous immunoglobulin (IVIG) therapy combined with corticosteroid and immunosuppressant treatment on clinical symptoms, including mononeuritis multiplex and cardiac dysfunction, and $ T_{reg} $ cell frequency, during EGPA. Whether the timing of administration (during initial treatment or at relapse after remission) or previous treatment affects the clinical and immunologic efficacy of IVIG is unknown. We evaluated whether the frequency of $ T_{reg} $ cells varied depending on when IVIG was provided relative to the start of conventional therapy for EGPA. Methods The patient population for this retrospective analysis comprised 17 patients with severe mononeuritis multiplex or heart failure whose EGPA did not respond to corticosteroids combined with immunosuppressant therapy. Ten patients first received IVIG during initial treatment, whereas the remaining 7 patients first received IVIG on relapse after remission. We measured the percentage of $ T_{reg} $ cells, defined as $ FOXP3^{+} %$ CD4^{+} $ T cells, present before the first round of IVIG and at 1 month after the last IVIG treatment. Results $ FOXP3^{+} %$ CD4^{+} $ T cells were increased in patients who required only a single course of IVIG to achieve remission compared with those who needed two or more courses. The dosage of prednisolone at initial IVIG was inversely correlated with the ratio of the number of $ FOXP3^{+} %$ CD4^{+} $ T cells before IVIG and that at 1 month thereafter. Conclusion Patients with severe EGPA who receive IVIG after nonresponse to high-dose prednisolone during initial treatment may need multiple courses of IVIG to achieve remission. An increase in the frequency of $ T_{reg} $ cells after IVIG may predict the need for additional IVIG in EGPA. |
abstract_unstemmed |
Background Regulatory T ($ T_{reg} $) cells are implicated in the development and progression of eosinophilic granulomatosis with polyangiitis (EGPA). We previously showed beneficial effects of intravenous immunoglobulin (IVIG) therapy combined with corticosteroid and immunosuppressant treatment on clinical symptoms, including mononeuritis multiplex and cardiac dysfunction, and $ T_{reg} $ cell frequency, during EGPA. Whether the timing of administration (during initial treatment or at relapse after remission) or previous treatment affects the clinical and immunologic efficacy of IVIG is unknown. We evaluated whether the frequency of $ T_{reg} $ cells varied depending on when IVIG was provided relative to the start of conventional therapy for EGPA. Methods The patient population for this retrospective analysis comprised 17 patients with severe mononeuritis multiplex or heart failure whose EGPA did not respond to corticosteroids combined with immunosuppressant therapy. Ten patients first received IVIG during initial treatment, whereas the remaining 7 patients first received IVIG on relapse after remission. We measured the percentage of $ T_{reg} $ cells, defined as $ FOXP3^{+} %$ CD4^{+} $ T cells, present before the first round of IVIG and at 1 month after the last IVIG treatment. Results $ FOXP3^{+} %$ CD4^{+} $ T cells were increased in patients who required only a single course of IVIG to achieve remission compared with those who needed two or more courses. The dosage of prednisolone at initial IVIG was inversely correlated with the ratio of the number of $ FOXP3^{+} %$ CD4^{+} $ T cells before IVIG and that at 1 month thereafter. Conclusion Patients with severe EGPA who receive IVIG after nonresponse to high-dose prednisolone during initial treatment may need multiple courses of IVIG to achieve remission. An increase in the frequency of $ T_{reg} $ cells after IVIG may predict the need for additional IVIG in EGPA. |
collection_details |
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High-dose intravenous immunoglobulin therapy for eosinophilic granulomatosis with polyangiitis |
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https://dx.doi.org/10.1186/2045-7022-4-38 |
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Saito, Hiroshi Oshikata, Chiyako Tsuburai, Takahiro Akiyama, Kazuo |
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We measured the percentage of $ T_{reg} $ cells, defined as $ FOXP3^{+} %$ CD4^{+} $ T cells, present before the first round of IVIG and at 1 month after the last IVIG treatment. Results $ FOXP3^{+} %$ CD4^{+} $ T cells were increased in patients who required only a single course of IVIG to achieve remission compared with those who needed two or more courses. The dosage of prednisolone at initial IVIG was inversely correlated with the ratio of the number of $ FOXP3^{+} %$ CD4^{+} $ T cells before IVIG and that at 1 month thereafter. Conclusion Patients with severe EGPA who receive IVIG after nonresponse to high-dose prednisolone during initial treatment may need multiple courses of IVIG to achieve remission. 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