Peak nasal inspiratory flow as outcome for provocation studies in allergen exposure chambers: a $ GA^{2} $LEN study
Background The $ GA^{2} $LEN chamber has been developed as a novel mobile allergen exposure chamber (AEC) allowing standardized multicenter trials in allergy. Hitherto, subjective nasal symptom scores have been the most often used outcome parameter, but in standardized modern trials objective parame...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Boelke, Georg [verfasserIn] Berger, Uwe [verfasserIn] Bergmann, Karl-Christian [verfasserIn] Bindslev-Jensen, Carsten [verfasserIn] Bousquet, Jean [verfasserIn] Gildemeister, Julia [verfasserIn] Jutel, Marek [verfasserIn] Pfaar, Oliver [verfasserIn] Sehlinger, Torsten [verfasserIn] Zuberbier, Torsten [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Schlagwörter: |
Allergen exposure chamber (AEC) |
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| Übergeordnetes Werk: |
Enthalten in: Clinical and translational allergy - Hoboken, NJ : Wiley, 2011, 7(2017), 1 vom: 17. Sept. |
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| Übergeordnetes Werk: |
volume:7 ; year:2017 ; number:1 ; day:17 ; month:09 |
| Links: |
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| DOI / URN: |
10.1186/s13601-017-0169-4 |
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| Katalog-ID: |
SPR031923399 |
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| 245 | 1 | 0 | |a Peak nasal inspiratory flow as outcome for provocation studies in allergen exposure chambers: a $ GA^{2} $LEN study |
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| 520 | |a Background The $ GA^{2} $LEN chamber has been developed as a novel mobile allergen exposure chamber (AEC) allowing standardized multicenter trials in allergy. Hitherto, subjective nasal symptom scores have been the most often used outcome parameter, but in standardized modern trials objective parameters are preferred. Despite its practicability, the objective parameter peak nasal inspiratory flow (PNIF) has been rarely used for allergy trials in the setting of allergen exposure chambers. This study aims to evaluate PNIF as an outcome parameter for provocation studies in AECs. Methods In a randomized controlled blinded setting subjects suffering from allergic rhinitis were exposed to grass pollen, birch pollen, house dust mite and/or placebo in the $ GA^{2} $LEN chamber. Different allergen concentrations were used to evaluate symptom severities. Patients had to perform PNIF before and every 30 min during a challenge using a portable PNIF meter. Results 86 subjects participated in 203 challenges, altogether. House dust mite provocations caused the greatest reduction in PNIF values, followed by grass pollen and birch pollen. Provocations with every allergen or pollen concentration led to a significant decrease (p < 0.05) in PNIF compared to baseline. Furthermore, positive correlations were obtained between PNIF and peak expiratory flow, height and weight, and inverse correlations between PNIF and total nasal symptom score, nasal congestion score and visual analog scale of overall subjective symptoms. Conclusion PNIF is a helpful and feasible tool for conducting provocation trials with allergens, especially grass pollen and house dust mite, in an AEC. | ||
| 650 | 4 | |a Allergen exposure chamber (AEC) |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Allergy trial |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a GA |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a LEN chamber |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Peak nasal inspiratory flow (PNIF) |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Provocation study |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Berger, Uwe |e verfasserin |4 aut | |
| 700 | 1 | |a Bergmann, Karl-Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Bindslev-Jensen, Carsten |e verfasserin |4 aut | |
| 700 | 1 | |a Bousquet, Jean |e verfasserin |4 aut | |
| 700 | 1 | |a Gildemeister, Julia |e verfasserin |4 aut | |
| 700 | 1 | |a Jutel, Marek |e verfasserin |4 aut | |
| 700 | 1 | |a Pfaar, Oliver |e verfasserin |4 aut | |
| 700 | 1 | |a Sehlinger, Torsten |e verfasserin |4 aut | |
| 700 | 1 | |a Zuberbier, Torsten |e verfasserin |4 aut | |
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10.1186/s13601-017-0169-4 doi (DE-627)SPR031923399 (SPR)s13601-017-0169-4-e DE-627 ger DE-627 rakwb eng 610 ASE Boelke, Georg verfasserin aut Peak nasal inspiratory flow as outcome for provocation studies in allergen exposure chambers: a $ GA^{2} $LEN study 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The $ GA^{2} $LEN chamber has been developed as a novel mobile allergen exposure chamber (AEC) allowing standardized multicenter trials in allergy. Hitherto, subjective nasal symptom scores have been the most often used outcome parameter, but in standardized modern trials objective parameters are preferred. Despite its practicability, the objective parameter peak nasal inspiratory flow (PNIF) has been rarely used for allergy trials in the setting of allergen exposure chambers. This study aims to evaluate PNIF as an outcome parameter for provocation studies in AECs. Methods In a randomized controlled blinded setting subjects suffering from allergic rhinitis were exposed to grass pollen, birch pollen, house dust mite and/or placebo in the $ GA^{2} $LEN chamber. Different allergen concentrations were used to evaluate symptom severities. Patients had to perform PNIF before and every 30 min during a challenge using a portable PNIF meter. Results 86 subjects participated in 203 challenges, altogether. House dust mite provocations caused the greatest reduction in PNIF values, followed by grass pollen and birch pollen. Provocations with every allergen or pollen concentration led to a significant decrease (p < 0.05) in PNIF compared to baseline. Furthermore, positive correlations were obtained between PNIF and peak expiratory flow, height and weight, and inverse correlations between PNIF and total nasal symptom score, nasal congestion score and visual analog scale of overall subjective symptoms. Conclusion PNIF is a helpful and feasible tool for conducting provocation trials with allergens, especially grass pollen and house dust mite, in an AEC. Allergen exposure chamber (AEC) (dpeaa)DE-He213 Allergy trial (dpeaa)DE-He213 GA (dpeaa)DE-He213 LEN chamber (dpeaa)DE-He213 Peak nasal inspiratory flow (PNIF) (dpeaa)DE-He213 Provocation study (dpeaa)DE-He213 Berger, Uwe verfasserin aut Bergmann, Karl-Christian verfasserin aut Bindslev-Jensen, Carsten verfasserin aut Bousquet, Jean verfasserin aut Gildemeister, Julia verfasserin aut Jutel, Marek verfasserin aut Pfaar, Oliver verfasserin aut Sehlinger, Torsten verfasserin aut Zuberbier, Torsten verfasserin aut Enthalten in Clinical and translational allergy Hoboken, NJ : Wiley, 2011 7(2017), 1 vom: 17. Sept. (DE-627)669883573 (DE-600)2630865-4 2045-7022 nnns volume:7 year:2017 number:1 day:17 month:09 https://dx.doi.org/10.1186/s13601-017-0169-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2017 1 17 09 |
| spelling |
10.1186/s13601-017-0169-4 doi (DE-627)SPR031923399 (SPR)s13601-017-0169-4-e DE-627 ger DE-627 rakwb eng 610 ASE Boelke, Georg verfasserin aut Peak nasal inspiratory flow as outcome for provocation studies in allergen exposure chambers: a $ GA^{2} $LEN study 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The $ GA^{2} $LEN chamber has been developed as a novel mobile allergen exposure chamber (AEC) allowing standardized multicenter trials in allergy. Hitherto, subjective nasal symptom scores have been the most often used outcome parameter, but in standardized modern trials objective parameters are preferred. Despite its practicability, the objective parameter peak nasal inspiratory flow (PNIF) has been rarely used for allergy trials in the setting of allergen exposure chambers. This study aims to evaluate PNIF as an outcome parameter for provocation studies in AECs. Methods In a randomized controlled blinded setting subjects suffering from allergic rhinitis were exposed to grass pollen, birch pollen, house dust mite and/or placebo in the $ GA^{2} $LEN chamber. Different allergen concentrations were used to evaluate symptom severities. Patients had to perform PNIF before and every 30 min during a challenge using a portable PNIF meter. Results 86 subjects participated in 203 challenges, altogether. House dust mite provocations caused the greatest reduction in PNIF values, followed by grass pollen and birch pollen. Provocations with every allergen or pollen concentration led to a significant decrease (p < 0.05) in PNIF compared to baseline. Furthermore, positive correlations were obtained between PNIF and peak expiratory flow, height and weight, and inverse correlations between PNIF and total nasal symptom score, nasal congestion score and visual analog scale of overall subjective symptoms. Conclusion PNIF is a helpful and feasible tool for conducting provocation trials with allergens, especially grass pollen and house dust mite, in an AEC. Allergen exposure chamber (AEC) (dpeaa)DE-He213 Allergy trial (dpeaa)DE-He213 GA (dpeaa)DE-He213 LEN chamber (dpeaa)DE-He213 Peak nasal inspiratory flow (PNIF) (dpeaa)DE-He213 Provocation study (dpeaa)DE-He213 Berger, Uwe verfasserin aut Bergmann, Karl-Christian verfasserin aut Bindslev-Jensen, Carsten verfasserin aut Bousquet, Jean verfasserin aut Gildemeister, Julia verfasserin aut Jutel, Marek verfasserin aut Pfaar, Oliver verfasserin aut Sehlinger, Torsten verfasserin aut Zuberbier, Torsten verfasserin aut Enthalten in Clinical and translational allergy Hoboken, NJ : Wiley, 2011 7(2017), 1 vom: 17. Sept. (DE-627)669883573 (DE-600)2630865-4 2045-7022 nnns volume:7 year:2017 number:1 day:17 month:09 https://dx.doi.org/10.1186/s13601-017-0169-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2017 1 17 09 |
| allfields_unstemmed |
10.1186/s13601-017-0169-4 doi (DE-627)SPR031923399 (SPR)s13601-017-0169-4-e DE-627 ger DE-627 rakwb eng 610 ASE Boelke, Georg verfasserin aut Peak nasal inspiratory flow as outcome for provocation studies in allergen exposure chambers: a $ GA^{2} $LEN study 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The $ GA^{2} $LEN chamber has been developed as a novel mobile allergen exposure chamber (AEC) allowing standardized multicenter trials in allergy. Hitherto, subjective nasal symptom scores have been the most often used outcome parameter, but in standardized modern trials objective parameters are preferred. Despite its practicability, the objective parameter peak nasal inspiratory flow (PNIF) has been rarely used for allergy trials in the setting of allergen exposure chambers. This study aims to evaluate PNIF as an outcome parameter for provocation studies in AECs. Methods In a randomized controlled blinded setting subjects suffering from allergic rhinitis were exposed to grass pollen, birch pollen, house dust mite and/or placebo in the $ GA^{2} $LEN chamber. Different allergen concentrations were used to evaluate symptom severities. Patients had to perform PNIF before and every 30 min during a challenge using a portable PNIF meter. Results 86 subjects participated in 203 challenges, altogether. House dust mite provocations caused the greatest reduction in PNIF values, followed by grass pollen and birch pollen. Provocations with every allergen or pollen concentration led to a significant decrease (p < 0.05) in PNIF compared to baseline. Furthermore, positive correlations were obtained between PNIF and peak expiratory flow, height and weight, and inverse correlations between PNIF and total nasal symptom score, nasal congestion score and visual analog scale of overall subjective symptoms. Conclusion PNIF is a helpful and feasible tool for conducting provocation trials with allergens, especially grass pollen and house dust mite, in an AEC. Allergen exposure chamber (AEC) (dpeaa)DE-He213 Allergy trial (dpeaa)DE-He213 GA (dpeaa)DE-He213 LEN chamber (dpeaa)DE-He213 Peak nasal inspiratory flow (PNIF) (dpeaa)DE-He213 Provocation study (dpeaa)DE-He213 Berger, Uwe verfasserin aut Bergmann, Karl-Christian verfasserin aut Bindslev-Jensen, Carsten verfasserin aut Bousquet, Jean verfasserin aut Gildemeister, Julia verfasserin aut Jutel, Marek verfasserin aut Pfaar, Oliver verfasserin aut Sehlinger, Torsten verfasserin aut Zuberbier, Torsten verfasserin aut Enthalten in Clinical and translational allergy Hoboken, NJ : Wiley, 2011 7(2017), 1 vom: 17. Sept. (DE-627)669883573 (DE-600)2630865-4 2045-7022 nnns volume:7 year:2017 number:1 day:17 month:09 https://dx.doi.org/10.1186/s13601-017-0169-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2017 1 17 09 |
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10.1186/s13601-017-0169-4 doi (DE-627)SPR031923399 (SPR)s13601-017-0169-4-e DE-627 ger DE-627 rakwb eng 610 ASE Boelke, Georg verfasserin aut Peak nasal inspiratory flow as outcome for provocation studies in allergen exposure chambers: a $ GA^{2} $LEN study 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The $ GA^{2} $LEN chamber has been developed as a novel mobile allergen exposure chamber (AEC) allowing standardized multicenter trials in allergy. Hitherto, subjective nasal symptom scores have been the most often used outcome parameter, but in standardized modern trials objective parameters are preferred. Despite its practicability, the objective parameter peak nasal inspiratory flow (PNIF) has been rarely used for allergy trials in the setting of allergen exposure chambers. This study aims to evaluate PNIF as an outcome parameter for provocation studies in AECs. Methods In a randomized controlled blinded setting subjects suffering from allergic rhinitis were exposed to grass pollen, birch pollen, house dust mite and/or placebo in the $ GA^{2} $LEN chamber. Different allergen concentrations were used to evaluate symptom severities. Patients had to perform PNIF before and every 30 min during a challenge using a portable PNIF meter. Results 86 subjects participated in 203 challenges, altogether. House dust mite provocations caused the greatest reduction in PNIF values, followed by grass pollen and birch pollen. Provocations with every allergen or pollen concentration led to a significant decrease (p < 0.05) in PNIF compared to baseline. Furthermore, positive correlations were obtained between PNIF and peak expiratory flow, height and weight, and inverse correlations between PNIF and total nasal symptom score, nasal congestion score and visual analog scale of overall subjective symptoms. Conclusion PNIF is a helpful and feasible tool for conducting provocation trials with allergens, especially grass pollen and house dust mite, in an AEC. Allergen exposure chamber (AEC) (dpeaa)DE-He213 Allergy trial (dpeaa)DE-He213 GA (dpeaa)DE-He213 LEN chamber (dpeaa)DE-He213 Peak nasal inspiratory flow (PNIF) (dpeaa)DE-He213 Provocation study (dpeaa)DE-He213 Berger, Uwe verfasserin aut Bergmann, Karl-Christian verfasserin aut Bindslev-Jensen, Carsten verfasserin aut Bousquet, Jean verfasserin aut Gildemeister, Julia verfasserin aut Jutel, Marek verfasserin aut Pfaar, Oliver verfasserin aut Sehlinger, Torsten verfasserin aut Zuberbier, Torsten verfasserin aut Enthalten in Clinical and translational allergy Hoboken, NJ : Wiley, 2011 7(2017), 1 vom: 17. Sept. (DE-627)669883573 (DE-600)2630865-4 2045-7022 nnns volume:7 year:2017 number:1 day:17 month:09 https://dx.doi.org/10.1186/s13601-017-0169-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2017 1 17 09 |
| allfieldsSound |
10.1186/s13601-017-0169-4 doi (DE-627)SPR031923399 (SPR)s13601-017-0169-4-e DE-627 ger DE-627 rakwb eng 610 ASE Boelke, Georg verfasserin aut Peak nasal inspiratory flow as outcome for provocation studies in allergen exposure chambers: a $ GA^{2} $LEN study 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The $ GA^{2} $LEN chamber has been developed as a novel mobile allergen exposure chamber (AEC) allowing standardized multicenter trials in allergy. Hitherto, subjective nasal symptom scores have been the most often used outcome parameter, but in standardized modern trials objective parameters are preferred. Despite its practicability, the objective parameter peak nasal inspiratory flow (PNIF) has been rarely used for allergy trials in the setting of allergen exposure chambers. This study aims to evaluate PNIF as an outcome parameter for provocation studies in AECs. Methods In a randomized controlled blinded setting subjects suffering from allergic rhinitis were exposed to grass pollen, birch pollen, house dust mite and/or placebo in the $ GA^{2} $LEN chamber. Different allergen concentrations were used to evaluate symptom severities. Patients had to perform PNIF before and every 30 min during a challenge using a portable PNIF meter. Results 86 subjects participated in 203 challenges, altogether. House dust mite provocations caused the greatest reduction in PNIF values, followed by grass pollen and birch pollen. Provocations with every allergen or pollen concentration led to a significant decrease (p < 0.05) in PNIF compared to baseline. Furthermore, positive correlations were obtained between PNIF and peak expiratory flow, height and weight, and inverse correlations between PNIF and total nasal symptom score, nasal congestion score and visual analog scale of overall subjective symptoms. Conclusion PNIF is a helpful and feasible tool for conducting provocation trials with allergens, especially grass pollen and house dust mite, in an AEC. Allergen exposure chamber (AEC) (dpeaa)DE-He213 Allergy trial (dpeaa)DE-He213 GA (dpeaa)DE-He213 LEN chamber (dpeaa)DE-He213 Peak nasal inspiratory flow (PNIF) (dpeaa)DE-He213 Provocation study (dpeaa)DE-He213 Berger, Uwe verfasserin aut Bergmann, Karl-Christian verfasserin aut Bindslev-Jensen, Carsten verfasserin aut Bousquet, Jean verfasserin aut Gildemeister, Julia verfasserin aut Jutel, Marek verfasserin aut Pfaar, Oliver verfasserin aut Sehlinger, Torsten verfasserin aut Zuberbier, Torsten verfasserin aut Enthalten in Clinical and translational allergy Hoboken, NJ : Wiley, 2011 7(2017), 1 vom: 17. Sept. (DE-627)669883573 (DE-600)2630865-4 2045-7022 nnns volume:7 year:2017 number:1 day:17 month:09 https://dx.doi.org/10.1186/s13601-017-0169-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2017 1 17 09 |
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Enthalten in Clinical and translational allergy 7(2017), 1 vom: 17. Sept. volume:7 year:2017 number:1 day:17 month:09 |
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Allergen exposure chamber (AEC) Allergy trial GA LEN chamber Peak nasal inspiratory flow (PNIF) Provocation study |
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Boelke, Georg @@aut@@ Berger, Uwe @@aut@@ Bergmann, Karl-Christian @@aut@@ Bindslev-Jensen, Carsten @@aut@@ Bousquet, Jean @@aut@@ Gildemeister, Julia @@aut@@ Jutel, Marek @@aut@@ Pfaar, Oliver @@aut@@ Sehlinger, Torsten @@aut@@ Zuberbier, Torsten @@aut@@ |
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Boelke, Georg |
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Boelke, Georg ddc 610 misc Allergen exposure chamber (AEC) misc Allergy trial misc GA misc LEN chamber misc Peak nasal inspiratory flow (PNIF) misc Provocation study Peak nasal inspiratory flow as outcome for provocation studies in allergen exposure chambers: a $ GA^{2} $LEN study |
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610 ASE Peak nasal inspiratory flow as outcome for provocation studies in allergen exposure chambers: a $ GA^{2} $LEN study Allergen exposure chamber (AEC) (dpeaa)DE-He213 Allergy trial (dpeaa)DE-He213 GA (dpeaa)DE-He213 LEN chamber (dpeaa)DE-He213 Peak nasal inspiratory flow (PNIF) (dpeaa)DE-He213 Provocation study (dpeaa)DE-He213 |
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ddc 610 misc Allergen exposure chamber (AEC) misc Allergy trial misc GA misc LEN chamber misc Peak nasal inspiratory flow (PNIF) misc Provocation study |
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ddc 610 misc Allergen exposure chamber (AEC) misc Allergy trial misc GA misc LEN chamber misc Peak nasal inspiratory flow (PNIF) misc Provocation study |
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ddc 610 misc Allergen exposure chamber (AEC) misc Allergy trial misc GA misc LEN chamber misc Peak nasal inspiratory flow (PNIF) misc Provocation study |
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Clinical and translational allergy |
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Clinical and translational allergy |
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Peak nasal inspiratory flow as outcome for provocation studies in allergen exposure chambers: a $ GA^{2} $LEN study |
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Peak nasal inspiratory flow as outcome for provocation studies in allergen exposure chambers: a $ GA^{2} $LEN study |
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Boelke, Georg |
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Clinical and translational allergy |
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Clinical and translational allergy |
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eng |
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600 - Technology |
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2017 |
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Boelke, Georg Berger, Uwe Bergmann, Karl-Christian Bindslev-Jensen, Carsten Bousquet, Jean Gildemeister, Julia Jutel, Marek Pfaar, Oliver Sehlinger, Torsten Zuberbier, Torsten |
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peak nasal inspiratory flow as outcome for provocation studies in allergen exposure chambers: a $ ga^{2} $len study |
| title_auth |
Peak nasal inspiratory flow as outcome for provocation studies in allergen exposure chambers: a $ GA^{2} $LEN study |
| abstract |
Background The $ GA^{2} $LEN chamber has been developed as a novel mobile allergen exposure chamber (AEC) allowing standardized multicenter trials in allergy. Hitherto, subjective nasal symptom scores have been the most often used outcome parameter, but in standardized modern trials objective parameters are preferred. Despite its practicability, the objective parameter peak nasal inspiratory flow (PNIF) has been rarely used for allergy trials in the setting of allergen exposure chambers. This study aims to evaluate PNIF as an outcome parameter for provocation studies in AECs. Methods In a randomized controlled blinded setting subjects suffering from allergic rhinitis were exposed to grass pollen, birch pollen, house dust mite and/or placebo in the $ GA^{2} $LEN chamber. Different allergen concentrations were used to evaluate symptom severities. Patients had to perform PNIF before and every 30 min during a challenge using a portable PNIF meter. Results 86 subjects participated in 203 challenges, altogether. House dust mite provocations caused the greatest reduction in PNIF values, followed by grass pollen and birch pollen. Provocations with every allergen or pollen concentration led to a significant decrease (p < 0.05) in PNIF compared to baseline. Furthermore, positive correlations were obtained between PNIF and peak expiratory flow, height and weight, and inverse correlations between PNIF and total nasal symptom score, nasal congestion score and visual analog scale of overall subjective symptoms. Conclusion PNIF is a helpful and feasible tool for conducting provocation trials with allergens, especially grass pollen and house dust mite, in an AEC. |
| abstractGer |
Background The $ GA^{2} $LEN chamber has been developed as a novel mobile allergen exposure chamber (AEC) allowing standardized multicenter trials in allergy. Hitherto, subjective nasal symptom scores have been the most often used outcome parameter, but in standardized modern trials objective parameters are preferred. Despite its practicability, the objective parameter peak nasal inspiratory flow (PNIF) has been rarely used for allergy trials in the setting of allergen exposure chambers. This study aims to evaluate PNIF as an outcome parameter for provocation studies in AECs. Methods In a randomized controlled blinded setting subjects suffering from allergic rhinitis were exposed to grass pollen, birch pollen, house dust mite and/or placebo in the $ GA^{2} $LEN chamber. Different allergen concentrations were used to evaluate symptom severities. Patients had to perform PNIF before and every 30 min during a challenge using a portable PNIF meter. Results 86 subjects participated in 203 challenges, altogether. House dust mite provocations caused the greatest reduction in PNIF values, followed by grass pollen and birch pollen. Provocations with every allergen or pollen concentration led to a significant decrease (p < 0.05) in PNIF compared to baseline. Furthermore, positive correlations were obtained between PNIF and peak expiratory flow, height and weight, and inverse correlations between PNIF and total nasal symptom score, nasal congestion score and visual analog scale of overall subjective symptoms. Conclusion PNIF is a helpful and feasible tool for conducting provocation trials with allergens, especially grass pollen and house dust mite, in an AEC. |
| abstract_unstemmed |
Background The $ GA^{2} $LEN chamber has been developed as a novel mobile allergen exposure chamber (AEC) allowing standardized multicenter trials in allergy. Hitherto, subjective nasal symptom scores have been the most often used outcome parameter, but in standardized modern trials objective parameters are preferred. Despite its practicability, the objective parameter peak nasal inspiratory flow (PNIF) has been rarely used for allergy trials in the setting of allergen exposure chambers. This study aims to evaluate PNIF as an outcome parameter for provocation studies in AECs. Methods In a randomized controlled blinded setting subjects suffering from allergic rhinitis were exposed to grass pollen, birch pollen, house dust mite and/or placebo in the $ GA^{2} $LEN chamber. Different allergen concentrations were used to evaluate symptom severities. Patients had to perform PNIF before and every 30 min during a challenge using a portable PNIF meter. Results 86 subjects participated in 203 challenges, altogether. House dust mite provocations caused the greatest reduction in PNIF values, followed by grass pollen and birch pollen. Provocations with every allergen or pollen concentration led to a significant decrease (p < 0.05) in PNIF compared to baseline. Furthermore, positive correlations were obtained between PNIF and peak expiratory flow, height and weight, and inverse correlations between PNIF and total nasal symptom score, nasal congestion score and visual analog scale of overall subjective symptoms. Conclusion PNIF is a helpful and feasible tool for conducting provocation trials with allergens, especially grass pollen and house dust mite, in an AEC. |
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Peak nasal inspiratory flow as outcome for provocation studies in allergen exposure chambers: a $ GA^{2} $LEN study |
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Berger, Uwe Bergmann, Karl-Christian Bindslev-Jensen, Carsten Bousquet, Jean Gildemeister, Julia Jutel, Marek Pfaar, Oliver Sehlinger, Torsten Zuberbier, Torsten |
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Berger, Uwe Bergmann, Karl-Christian Bindslev-Jensen, Carsten Bousquet, Jean Gildemeister, Julia Jutel, Marek Pfaar, Oliver Sehlinger, Torsten Zuberbier, Torsten |
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2024-07-04T01:50:48.053Z |
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Hitherto, subjective nasal symptom scores have been the most often used outcome parameter, but in standardized modern trials objective parameters are preferred. Despite its practicability, the objective parameter peak nasal inspiratory flow (PNIF) has been rarely used for allergy trials in the setting of allergen exposure chambers. This study aims to evaluate PNIF as an outcome parameter for provocation studies in AECs. Methods In a randomized controlled blinded setting subjects suffering from allergic rhinitis were exposed to grass pollen, birch pollen, house dust mite and/or placebo in the $ GA^{2} $LEN chamber. Different allergen concentrations were used to evaluate symptom severities. Patients had to perform PNIF before and every 30 min during a challenge using a portable PNIF meter. Results 86 subjects participated in 203 challenges, altogether. House dust mite provocations caused the greatest reduction in PNIF values, followed by grass pollen and birch pollen. Provocations with every allergen or pollen concentration led to a significant decrease (p < 0.05) in PNIF compared to baseline. Furthermore, positive correlations were obtained between PNIF and peak expiratory flow, height and weight, and inverse correlations between PNIF and total nasal symptom score, nasal congestion score and visual analog scale of overall subjective symptoms. 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