A meta-analysis of baseline characteristics in trials on mite allergen avoidance in asthmatics: room for improvement
Background Evidence regarding the clinical effectiveness of mite allergen avoidance for the treatment of asthma is lacking. In previous meta-analyses on mite allergen control, the baseline data were not discussed in detail. This study updates and extends the existing Cochrane review by Gøtzsche and...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
van Boven, Frank E. [verfasserIn] de Jong, Nicolette W. [verfasserIn] Braunstahl, Gert-Jan [verfasserIn] Gerth van Wijk, Roy [verfasserIn] Arends, Lidia R. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Übergeordnetes Werk: |
Enthalten in: Clinical and translational allergy - Hoboken, NJ : Wiley, 2011, 10(2020), 1 vom: 06. Jan. |
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| Übergeordnetes Werk: |
volume:10 ; year:2020 ; number:1 ; day:06 ; month:01 |
| Links: |
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| DOI / URN: |
10.1186/s13601-019-0306-3 |
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| Katalog-ID: |
SPR031924921 |
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| 520 | |a Background Evidence regarding the clinical effectiveness of mite allergen avoidance for the treatment of asthma is lacking. In previous meta-analyses on mite allergen control, the baseline data were not discussed in detail. This study updates and extends the existing Cochrane review by Gøtzsche and Johansen (Cochrane Database of Systematic Reviews, 2008, Art. No: CD001187), with a focus on baseline asthma outcomes and allergen exposures. Methods We used the existing trials in the original Cochrane review and included newly published studies. The baseline data for the mite allergen load from the mattress, the standardized asthma symptom score (ASS), the forced expiratory volume in 1 s percentage of predicted ($ FEV_{1} $ %pred.), and the histamine provocative concentration causing a 20% drop in $ FEV_{1} $ ($ PC_{20} $) were extracted. First, the mean values of the outcomes were calculated. The influence of the mite allergen load was examined with a random-effect meta-regression using the Metafor package in R. Results Forty-five trials were included; 39 trials reported strategies for concurrent bedroom interventions, and 6 trails reported strategies for air purification. The mite allergen load ranged from 0.44 to 24.83 μg/g dust, with a mean of 9.86 μg/g dust (95% CI 5.66 to 14.05 μg/g dust, $ I^{2} $ = 99.8%). All health outcomes showed considerable heterogeneity (standardized ASS mean: 0.13, 95% CI 0.08 to 0.18, $ I^{2} $ = 99.9%; $ FEV_{1} $ %pred. mean: 85.3%, 95% CI 80.5 to 90.1%, $ I^{2} $ = 95.8%; $ PC_{20} $ mean: 1.69 mg/mL, 95% CI 0.86 to 2.52 mg/mL, $ I^{2} $ = 95.6%). The covariate mite allergen load did not significantly influence health outcomes. Discussion This meta-analysis shows that mite avoidance studies are characterized by the inclusion of patients with rather mild to moderate asthma and with varying and sometimes negligible levels of allergen exposure. Future studies should focus on patients with severe asthma and increased levels of allergen exposure. | ||
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| 700 | 1 | |a Braunstahl, Gert-Jan |e verfasserin |4 aut | |
| 700 | 1 | |a Gerth van Wijk, Roy |e verfasserin |4 aut | |
| 700 | 1 | |a Arends, Lidia R. |e verfasserin |4 aut | |
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10.1186/s13601-019-0306-3 doi (DE-627)SPR031924921 (SPR)s13601-019-0306-3-e DE-627 ger DE-627 rakwb eng 610 ASE van Boven, Frank E. verfasserin aut A meta-analysis of baseline characteristics in trials on mite allergen avoidance in asthmatics: room for improvement 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Evidence regarding the clinical effectiveness of mite allergen avoidance for the treatment of asthma is lacking. In previous meta-analyses on mite allergen control, the baseline data were not discussed in detail. This study updates and extends the existing Cochrane review by Gøtzsche and Johansen (Cochrane Database of Systematic Reviews, 2008, Art. No: CD001187), with a focus on baseline asthma outcomes and allergen exposures. Methods We used the existing trials in the original Cochrane review and included newly published studies. The baseline data for the mite allergen load from the mattress, the standardized asthma symptom score (ASS), the forced expiratory volume in 1 s percentage of predicted ($ FEV_{1} $ %pred.), and the histamine provocative concentration causing a 20% drop in $ FEV_{1} $ ($ PC_{20} $) were extracted. First, the mean values of the outcomes were calculated. The influence of the mite allergen load was examined with a random-effect meta-regression using the Metafor package in R. Results Forty-five trials were included; 39 trials reported strategies for concurrent bedroom interventions, and 6 trails reported strategies for air purification. The mite allergen load ranged from 0.44 to 24.83 μg/g dust, with a mean of 9.86 μg/g dust (95% CI 5.66 to 14.05 μg/g dust, $ I^{2} $ = 99.8%). All health outcomes showed considerable heterogeneity (standardized ASS mean: 0.13, 95% CI 0.08 to 0.18, $ I^{2} $ = 99.9%; $ FEV_{1} $ %pred. mean: 85.3%, 95% CI 80.5 to 90.1%, $ I^{2} $ = 95.8%; $ PC_{20} $ mean: 1.69 mg/mL, 95% CI 0.86 to 2.52 mg/mL, $ I^{2} $ = 95.6%). The covariate mite allergen load did not significantly influence health outcomes. Discussion This meta-analysis shows that mite avoidance studies are characterized by the inclusion of patients with rather mild to moderate asthma and with varying and sometimes negligible levels of allergen exposure. Future studies should focus on patients with severe asthma and increased levels of allergen exposure. de Jong, Nicolette W. verfasserin aut Braunstahl, Gert-Jan verfasserin aut Gerth van Wijk, Roy verfasserin aut Arends, Lidia R. verfasserin aut Enthalten in Clinical and translational allergy Hoboken, NJ : Wiley, 2011 10(2020), 1 vom: 06. Jan. (DE-627)669883573 (DE-600)2630865-4 2045-7022 nnns volume:10 year:2020 number:1 day:06 month:01 https://dx.doi.org/10.1186/s13601-019-0306-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 1 06 01 |
| spelling |
10.1186/s13601-019-0306-3 doi (DE-627)SPR031924921 (SPR)s13601-019-0306-3-e DE-627 ger DE-627 rakwb eng 610 ASE van Boven, Frank E. verfasserin aut A meta-analysis of baseline characteristics in trials on mite allergen avoidance in asthmatics: room for improvement 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Evidence regarding the clinical effectiveness of mite allergen avoidance for the treatment of asthma is lacking. In previous meta-analyses on mite allergen control, the baseline data were not discussed in detail. This study updates and extends the existing Cochrane review by Gøtzsche and Johansen (Cochrane Database of Systematic Reviews, 2008, Art. No: CD001187), with a focus on baseline asthma outcomes and allergen exposures. Methods We used the existing trials in the original Cochrane review and included newly published studies. The baseline data for the mite allergen load from the mattress, the standardized asthma symptom score (ASS), the forced expiratory volume in 1 s percentage of predicted ($ FEV_{1} $ %pred.), and the histamine provocative concentration causing a 20% drop in $ FEV_{1} $ ($ PC_{20} $) were extracted. First, the mean values of the outcomes were calculated. The influence of the mite allergen load was examined with a random-effect meta-regression using the Metafor package in R. Results Forty-five trials were included; 39 trials reported strategies for concurrent bedroom interventions, and 6 trails reported strategies for air purification. The mite allergen load ranged from 0.44 to 24.83 μg/g dust, with a mean of 9.86 μg/g dust (95% CI 5.66 to 14.05 μg/g dust, $ I^{2} $ = 99.8%). All health outcomes showed considerable heterogeneity (standardized ASS mean: 0.13, 95% CI 0.08 to 0.18, $ I^{2} $ = 99.9%; $ FEV_{1} $ %pred. mean: 85.3%, 95% CI 80.5 to 90.1%, $ I^{2} $ = 95.8%; $ PC_{20} $ mean: 1.69 mg/mL, 95% CI 0.86 to 2.52 mg/mL, $ I^{2} $ = 95.6%). The covariate mite allergen load did not significantly influence health outcomes. Discussion This meta-analysis shows that mite avoidance studies are characterized by the inclusion of patients with rather mild to moderate asthma and with varying and sometimes negligible levels of allergen exposure. Future studies should focus on patients with severe asthma and increased levels of allergen exposure. de Jong, Nicolette W. verfasserin aut Braunstahl, Gert-Jan verfasserin aut Gerth van Wijk, Roy verfasserin aut Arends, Lidia R. verfasserin aut Enthalten in Clinical and translational allergy Hoboken, NJ : Wiley, 2011 10(2020), 1 vom: 06. Jan. (DE-627)669883573 (DE-600)2630865-4 2045-7022 nnns volume:10 year:2020 number:1 day:06 month:01 https://dx.doi.org/10.1186/s13601-019-0306-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 1 06 01 |
| allfields_unstemmed |
10.1186/s13601-019-0306-3 doi (DE-627)SPR031924921 (SPR)s13601-019-0306-3-e DE-627 ger DE-627 rakwb eng 610 ASE van Boven, Frank E. verfasserin aut A meta-analysis of baseline characteristics in trials on mite allergen avoidance in asthmatics: room for improvement 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Evidence regarding the clinical effectiveness of mite allergen avoidance for the treatment of asthma is lacking. In previous meta-analyses on mite allergen control, the baseline data were not discussed in detail. This study updates and extends the existing Cochrane review by Gøtzsche and Johansen (Cochrane Database of Systematic Reviews, 2008, Art. No: CD001187), with a focus on baseline asthma outcomes and allergen exposures. Methods We used the existing trials in the original Cochrane review and included newly published studies. The baseline data for the mite allergen load from the mattress, the standardized asthma symptom score (ASS), the forced expiratory volume in 1 s percentage of predicted ($ FEV_{1} $ %pred.), and the histamine provocative concentration causing a 20% drop in $ FEV_{1} $ ($ PC_{20} $) were extracted. First, the mean values of the outcomes were calculated. The influence of the mite allergen load was examined with a random-effect meta-regression using the Metafor package in R. Results Forty-five trials were included; 39 trials reported strategies for concurrent bedroom interventions, and 6 trails reported strategies for air purification. The mite allergen load ranged from 0.44 to 24.83 μg/g dust, with a mean of 9.86 μg/g dust (95% CI 5.66 to 14.05 μg/g dust, $ I^{2} $ = 99.8%). All health outcomes showed considerable heterogeneity (standardized ASS mean: 0.13, 95% CI 0.08 to 0.18, $ I^{2} $ = 99.9%; $ FEV_{1} $ %pred. mean: 85.3%, 95% CI 80.5 to 90.1%, $ I^{2} $ = 95.8%; $ PC_{20} $ mean: 1.69 mg/mL, 95% CI 0.86 to 2.52 mg/mL, $ I^{2} $ = 95.6%). The covariate mite allergen load did not significantly influence health outcomes. Discussion This meta-analysis shows that mite avoidance studies are characterized by the inclusion of patients with rather mild to moderate asthma and with varying and sometimes negligible levels of allergen exposure. Future studies should focus on patients with severe asthma and increased levels of allergen exposure. de Jong, Nicolette W. verfasserin aut Braunstahl, Gert-Jan verfasserin aut Gerth van Wijk, Roy verfasserin aut Arends, Lidia R. verfasserin aut Enthalten in Clinical and translational allergy Hoboken, NJ : Wiley, 2011 10(2020), 1 vom: 06. Jan. (DE-627)669883573 (DE-600)2630865-4 2045-7022 nnns volume:10 year:2020 number:1 day:06 month:01 https://dx.doi.org/10.1186/s13601-019-0306-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 1 06 01 |
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10.1186/s13601-019-0306-3 doi (DE-627)SPR031924921 (SPR)s13601-019-0306-3-e DE-627 ger DE-627 rakwb eng 610 ASE van Boven, Frank E. verfasserin aut A meta-analysis of baseline characteristics in trials on mite allergen avoidance in asthmatics: room for improvement 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Evidence regarding the clinical effectiveness of mite allergen avoidance for the treatment of asthma is lacking. In previous meta-analyses on mite allergen control, the baseline data were not discussed in detail. This study updates and extends the existing Cochrane review by Gøtzsche and Johansen (Cochrane Database of Systematic Reviews, 2008, Art. No: CD001187), with a focus on baseline asthma outcomes and allergen exposures. Methods We used the existing trials in the original Cochrane review and included newly published studies. The baseline data for the mite allergen load from the mattress, the standardized asthma symptom score (ASS), the forced expiratory volume in 1 s percentage of predicted ($ FEV_{1} $ %pred.), and the histamine provocative concentration causing a 20% drop in $ FEV_{1} $ ($ PC_{20} $) were extracted. First, the mean values of the outcomes were calculated. The influence of the mite allergen load was examined with a random-effect meta-regression using the Metafor package in R. Results Forty-five trials were included; 39 trials reported strategies for concurrent bedroom interventions, and 6 trails reported strategies for air purification. The mite allergen load ranged from 0.44 to 24.83 μg/g dust, with a mean of 9.86 μg/g dust (95% CI 5.66 to 14.05 μg/g dust, $ I^{2} $ = 99.8%). All health outcomes showed considerable heterogeneity (standardized ASS mean: 0.13, 95% CI 0.08 to 0.18, $ I^{2} $ = 99.9%; $ FEV_{1} $ %pred. mean: 85.3%, 95% CI 80.5 to 90.1%, $ I^{2} $ = 95.8%; $ PC_{20} $ mean: 1.69 mg/mL, 95% CI 0.86 to 2.52 mg/mL, $ I^{2} $ = 95.6%). The covariate mite allergen load did not significantly influence health outcomes. Discussion This meta-analysis shows that mite avoidance studies are characterized by the inclusion of patients with rather mild to moderate asthma and with varying and sometimes negligible levels of allergen exposure. Future studies should focus on patients with severe asthma and increased levels of allergen exposure. de Jong, Nicolette W. verfasserin aut Braunstahl, Gert-Jan verfasserin aut Gerth van Wijk, Roy verfasserin aut Arends, Lidia R. verfasserin aut Enthalten in Clinical and translational allergy Hoboken, NJ : Wiley, 2011 10(2020), 1 vom: 06. Jan. (DE-627)669883573 (DE-600)2630865-4 2045-7022 nnns volume:10 year:2020 number:1 day:06 month:01 https://dx.doi.org/10.1186/s13601-019-0306-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 1 06 01 |
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10.1186/s13601-019-0306-3 doi (DE-627)SPR031924921 (SPR)s13601-019-0306-3-e DE-627 ger DE-627 rakwb eng 610 ASE van Boven, Frank E. verfasserin aut A meta-analysis of baseline characteristics in trials on mite allergen avoidance in asthmatics: room for improvement 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Evidence regarding the clinical effectiveness of mite allergen avoidance for the treatment of asthma is lacking. In previous meta-analyses on mite allergen control, the baseline data were not discussed in detail. This study updates and extends the existing Cochrane review by Gøtzsche and Johansen (Cochrane Database of Systematic Reviews, 2008, Art. No: CD001187), with a focus on baseline asthma outcomes and allergen exposures. Methods We used the existing trials in the original Cochrane review and included newly published studies. The baseline data for the mite allergen load from the mattress, the standardized asthma symptom score (ASS), the forced expiratory volume in 1 s percentage of predicted ($ FEV_{1} $ %pred.), and the histamine provocative concentration causing a 20% drop in $ FEV_{1} $ ($ PC_{20} $) were extracted. First, the mean values of the outcomes were calculated. The influence of the mite allergen load was examined with a random-effect meta-regression using the Metafor package in R. Results Forty-five trials were included; 39 trials reported strategies for concurrent bedroom interventions, and 6 trails reported strategies for air purification. The mite allergen load ranged from 0.44 to 24.83 μg/g dust, with a mean of 9.86 μg/g dust (95% CI 5.66 to 14.05 μg/g dust, $ I^{2} $ = 99.8%). All health outcomes showed considerable heterogeneity (standardized ASS mean: 0.13, 95% CI 0.08 to 0.18, $ I^{2} $ = 99.9%; $ FEV_{1} $ %pred. mean: 85.3%, 95% CI 80.5 to 90.1%, $ I^{2} $ = 95.8%; $ PC_{20} $ mean: 1.69 mg/mL, 95% CI 0.86 to 2.52 mg/mL, $ I^{2} $ = 95.6%). The covariate mite allergen load did not significantly influence health outcomes. Discussion This meta-analysis shows that mite avoidance studies are characterized by the inclusion of patients with rather mild to moderate asthma and with varying and sometimes negligible levels of allergen exposure. Future studies should focus on patients with severe asthma and increased levels of allergen exposure. de Jong, Nicolette W. verfasserin aut Braunstahl, Gert-Jan verfasserin aut Gerth van Wijk, Roy verfasserin aut Arends, Lidia R. verfasserin aut Enthalten in Clinical and translational allergy Hoboken, NJ : Wiley, 2011 10(2020), 1 vom: 06. Jan. (DE-627)669883573 (DE-600)2630865-4 2045-7022 nnns volume:10 year:2020 number:1 day:06 month:01 https://dx.doi.org/10.1186/s13601-019-0306-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020 1 06 01 |
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In previous meta-analyses on mite allergen control, the baseline data were not discussed in detail. This study updates and extends the existing Cochrane review by Gøtzsche and Johansen (Cochrane Database of Systematic Reviews, 2008, Art. No: CD001187), with a focus on baseline asthma outcomes and allergen exposures. Methods We used the existing trials in the original Cochrane review and included newly published studies. The baseline data for the mite allergen load from the mattress, the standardized asthma symptom score (ASS), the forced expiratory volume in 1 s percentage of predicted ($ FEV_{1} $ %pred.), and the histamine provocative concentration causing a 20% drop in $ FEV_{1} $ ($ PC_{20} $) were extracted. First, the mean values of the outcomes were calculated. The influence of the mite allergen load was examined with a random-effect meta-regression using the Metafor package in R. Results Forty-five trials were included; 39 trials reported strategies for concurrent bedroom interventions, and 6 trails reported strategies for air purification. The mite allergen load ranged from 0.44 to 24.83 μg/g dust, with a mean of 9.86 μg/g dust (95% CI 5.66 to 14.05 μg/g dust, $ I^{2} $ = 99.8%). All health outcomes showed considerable heterogeneity (standardized ASS mean: 0.13, 95% CI 0.08 to 0.18, $ I^{2} $ = 99.9%; $ FEV_{1} $ %pred. mean: 85.3%, 95% CI 80.5 to 90.1%, $ I^{2} $ = 95.8%; $ PC_{20} $ mean: 1.69 mg/mL, 95% CI 0.86 to 2.52 mg/mL, $ I^{2} $ = 95.6%). The covariate mite allergen load did not significantly influence health outcomes. Discussion This meta-analysis shows that mite avoidance studies are characterized by the inclusion of patients with rather mild to moderate asthma and with varying and sometimes negligible levels of allergen exposure. 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van Boven, Frank E. ddc 610 A meta-analysis of baseline characteristics in trials on mite allergen avoidance in asthmatics: room for improvement |
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van Boven, Frank E. de Jong, Nicolette W. Braunstahl, Gert-Jan Gerth van Wijk, Roy Arends, Lidia R. |
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meta-analysis of baseline characteristics in trials on mite allergen avoidance in asthmatics: room for improvement |
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A meta-analysis of baseline characteristics in trials on mite allergen avoidance in asthmatics: room for improvement |
| abstract |
Background Evidence regarding the clinical effectiveness of mite allergen avoidance for the treatment of asthma is lacking. In previous meta-analyses on mite allergen control, the baseline data were not discussed in detail. This study updates and extends the existing Cochrane review by Gøtzsche and Johansen (Cochrane Database of Systematic Reviews, 2008, Art. No: CD001187), with a focus on baseline asthma outcomes and allergen exposures. Methods We used the existing trials in the original Cochrane review and included newly published studies. The baseline data for the mite allergen load from the mattress, the standardized asthma symptom score (ASS), the forced expiratory volume in 1 s percentage of predicted ($ FEV_{1} $ %pred.), and the histamine provocative concentration causing a 20% drop in $ FEV_{1} $ ($ PC_{20} $) were extracted. First, the mean values of the outcomes were calculated. The influence of the mite allergen load was examined with a random-effect meta-regression using the Metafor package in R. Results Forty-five trials were included; 39 trials reported strategies for concurrent bedroom interventions, and 6 trails reported strategies for air purification. The mite allergen load ranged from 0.44 to 24.83 μg/g dust, with a mean of 9.86 μg/g dust (95% CI 5.66 to 14.05 μg/g dust, $ I^{2} $ = 99.8%). All health outcomes showed considerable heterogeneity (standardized ASS mean: 0.13, 95% CI 0.08 to 0.18, $ I^{2} $ = 99.9%; $ FEV_{1} $ %pred. mean: 85.3%, 95% CI 80.5 to 90.1%, $ I^{2} $ = 95.8%; $ PC_{20} $ mean: 1.69 mg/mL, 95% CI 0.86 to 2.52 mg/mL, $ I^{2} $ = 95.6%). The covariate mite allergen load did not significantly influence health outcomes. Discussion This meta-analysis shows that mite avoidance studies are characterized by the inclusion of patients with rather mild to moderate asthma and with varying and sometimes negligible levels of allergen exposure. Future studies should focus on patients with severe asthma and increased levels of allergen exposure. |
| abstractGer |
Background Evidence regarding the clinical effectiveness of mite allergen avoidance for the treatment of asthma is lacking. In previous meta-analyses on mite allergen control, the baseline data were not discussed in detail. This study updates and extends the existing Cochrane review by Gøtzsche and Johansen (Cochrane Database of Systematic Reviews, 2008, Art. No: CD001187), with a focus on baseline asthma outcomes and allergen exposures. Methods We used the existing trials in the original Cochrane review and included newly published studies. The baseline data for the mite allergen load from the mattress, the standardized asthma symptom score (ASS), the forced expiratory volume in 1 s percentage of predicted ($ FEV_{1} $ %pred.), and the histamine provocative concentration causing a 20% drop in $ FEV_{1} $ ($ PC_{20} $) were extracted. First, the mean values of the outcomes were calculated. The influence of the mite allergen load was examined with a random-effect meta-regression using the Metafor package in R. Results Forty-five trials were included; 39 trials reported strategies for concurrent bedroom interventions, and 6 trails reported strategies for air purification. The mite allergen load ranged from 0.44 to 24.83 μg/g dust, with a mean of 9.86 μg/g dust (95% CI 5.66 to 14.05 μg/g dust, $ I^{2} $ = 99.8%). All health outcomes showed considerable heterogeneity (standardized ASS mean: 0.13, 95% CI 0.08 to 0.18, $ I^{2} $ = 99.9%; $ FEV_{1} $ %pred. mean: 85.3%, 95% CI 80.5 to 90.1%, $ I^{2} $ = 95.8%; $ PC_{20} $ mean: 1.69 mg/mL, 95% CI 0.86 to 2.52 mg/mL, $ I^{2} $ = 95.6%). The covariate mite allergen load did not significantly influence health outcomes. Discussion This meta-analysis shows that mite avoidance studies are characterized by the inclusion of patients with rather mild to moderate asthma and with varying and sometimes negligible levels of allergen exposure. Future studies should focus on patients with severe asthma and increased levels of allergen exposure. |
| abstract_unstemmed |
Background Evidence regarding the clinical effectiveness of mite allergen avoidance for the treatment of asthma is lacking. In previous meta-analyses on mite allergen control, the baseline data were not discussed in detail. This study updates and extends the existing Cochrane review by Gøtzsche and Johansen (Cochrane Database of Systematic Reviews, 2008, Art. No: CD001187), with a focus on baseline asthma outcomes and allergen exposures. Methods We used the existing trials in the original Cochrane review and included newly published studies. The baseline data for the mite allergen load from the mattress, the standardized asthma symptom score (ASS), the forced expiratory volume in 1 s percentage of predicted ($ FEV_{1} $ %pred.), and the histamine provocative concentration causing a 20% drop in $ FEV_{1} $ ($ PC_{20} $) were extracted. First, the mean values of the outcomes were calculated. The influence of the mite allergen load was examined with a random-effect meta-regression using the Metafor package in R. Results Forty-five trials were included; 39 trials reported strategies for concurrent bedroom interventions, and 6 trails reported strategies for air purification. The mite allergen load ranged from 0.44 to 24.83 μg/g dust, with a mean of 9.86 μg/g dust (95% CI 5.66 to 14.05 μg/g dust, $ I^{2} $ = 99.8%). All health outcomes showed considerable heterogeneity (standardized ASS mean: 0.13, 95% CI 0.08 to 0.18, $ I^{2} $ = 99.9%; $ FEV_{1} $ %pred. mean: 85.3%, 95% CI 80.5 to 90.1%, $ I^{2} $ = 95.8%; $ PC_{20} $ mean: 1.69 mg/mL, 95% CI 0.86 to 2.52 mg/mL, $ I^{2} $ = 95.6%). The covariate mite allergen load did not significantly influence health outcomes. Discussion This meta-analysis shows that mite avoidance studies are characterized by the inclusion of patients with rather mild to moderate asthma and with varying and sometimes negligible levels of allergen exposure. Future studies should focus on patients with severe asthma and increased levels of allergen exposure. |
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Results Forty-five trials were included; 39 trials reported strategies for concurrent bedroom interventions, and 6 trails reported strategies for air purification. The mite allergen load ranged from 0.44 to 24.83 μg/g dust, with a mean of 9.86 μg/g dust (95% CI 5.66 to 14.05 μg/g dust, $ I^{2} $ = 99.8%). All health outcomes showed considerable heterogeneity (standardized ASS mean: 0.13, 95% CI 0.08 to 0.18, $ I^{2} $ = 99.9%; $ FEV_{1} $ %pred. mean: 85.3%, 95% CI 80.5 to 90.1%, $ I^{2} $ = 95.8%; $ PC_{20} $ mean: 1.69 mg/mL, 95% CI 0.86 to 2.52 mg/mL, $ I^{2} $ = 95.6%). The covariate mite allergen load did not significantly influence health outcomes. Discussion This meta-analysis shows that mite avoidance studies are characterized by the inclusion of patients with rather mild to moderate asthma and with varying and sometimes negligible levels of allergen exposure. 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