FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study

Background Fibroblast growth factor-23 (FGF-23), a novel regulator of mineral metabolism, is markedly elevated in chronic kidney disease and has been associated with poor long-term outcomes. However, whether FGF-23 has an analogous role in acute kidney injury is unknown. The goal of this study was t...
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Autor*in:	Zhang, MaryAnn [verfasserIn] Hsu, Raymond [verfasserIn] Hsu, Chi-yuan [verfasserIn] Kordesch, Kristina [verfasserIn] Nicasio, Erica [verfasserIn] Cortez, Alfredo [verfasserIn] McAlpine, Ian [verfasserIn] Brady, Sandra [verfasserIn] Zhuo, Hanjing [verfasserIn] Kangelaris, Kirsten N [verfasserIn] Stein, John [verfasserIn] Calfee, Carolyn S [verfasserIn] Liu, Kathleen D [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2011

Schlagwörter:	Chronic Kidney Disease Acute Kidney Injury Chronic Kidney Disease Patient Cinacalcet Acute Kidney Injury Patient

Übergeordnetes Werk:	Enthalten in: Annals of intensive care - Heidelberg : Springer, 2011, 1(2011), 1 vom: 14. Juni
Übergeordnetes Werk:	volume:1 ; year:2011 ; number:1 ; day:14 ; month:06

Links:	Volltext

DOI / URN:	10.1186/2110-5820-1-21

Katalog-ID:	SPR031925731

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520			\|a Background Fibroblast growth factor-23 (FGF-23), a novel regulator of mineral metabolism, is markedly elevated in chronic kidney disease and has been associated with poor long-term outcomes. However, whether FGF-23 has an analogous role in acute kidney injury is unknown. The goal of this study was to measure FGF-23 levels in critically ill patients with acute kidney injury to determine whether FGF-23 levels were elevated, as in chronic kidney disease. Methods Plasma FGF-23 and intact parathyroid hormone (PTH) levels were measured in 12 patients with acute kidney injury and 8 control subjects. Results FGF-23 levels were significantly higher in acute kidney injury cases than in critically ill subjects without acute kidney injury, with a median FGF-23 level of 1948 RU/mL (interquartile range (IQR), 437-4369) in cases compared with 252 RU/mL (IQR, 65-533) in controls (p = 0.01). No correlations were observed between FGF-23 and severity of acute kidney injury (defined by the Acute Kidney Injury Network criteria); among patients with acute kidney injury, FGF-23 levels were higher in nonsurvivors than survivors (median levels of 4446 RU/mL (IQR, 3455-5443) versus 544 RU/mL (IQR, 390-1948; p = 0.02). Severe hyperparathyroidism (defined as intact PTH >250 mg/dL) was present in 3 of 12 (25%) of the acute kidney injury subjects versus none of the subjects without acute kidney injury, although this result did not meet statistical significance. Conclusions We provide novel data that demonstrate that FGF-23 levels are elevated in acute kidney injury, suggesting that FGF-23 dysregulation occurs in acute kidney injury as well as chronic kidney disease. Further studies are needed to define the short- and long-term clinical effects of dysregulated mineral metabolism in acute kidney injury patients.
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650		4	\|a Chronic Kidney Disease Patient \|7 (dpeaa)DE-He213
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700	1		\|a Calfee, Carolyn S \|e verfasserin \|4 aut
700	1		\|a Liu, Kathleen D \|e verfasserin \|4 aut
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allfields	10.1186/2110-5820-1-21 doi (DE-627)SPR031925731 (SPR)2110-5820-1-21-e DE-627 ger DE-627 rakwb eng 610 ASE Zhang, MaryAnn verfasserin aut FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Fibroblast growth factor-23 (FGF-23), a novel regulator of mineral metabolism, is markedly elevated in chronic kidney disease and has been associated with poor long-term outcomes. However, whether FGF-23 has an analogous role in acute kidney injury is unknown. The goal of this study was to measure FGF-23 levels in critically ill patients with acute kidney injury to determine whether FGF-23 levels were elevated, as in chronic kidney disease. Methods Plasma FGF-23 and intact parathyroid hormone (PTH) levels were measured in 12 patients with acute kidney injury and 8 control subjects. Results FGF-23 levels were significantly higher in acute kidney injury cases than in critically ill subjects without acute kidney injury, with a median FGF-23 level of 1948 RU/mL (interquartile range (IQR), 437-4369) in cases compared with 252 RU/mL (IQR, 65-533) in controls (p = 0.01). No correlations were observed between FGF-23 and severity of acute kidney injury (defined by the Acute Kidney Injury Network criteria); among patients with acute kidney injury, FGF-23 levels were higher in nonsurvivors than survivors (median levels of 4446 RU/mL (IQR, 3455-5443) versus 544 RU/mL (IQR, 390-1948; p = 0.02). Severe hyperparathyroidism (defined as intact PTH >250 mg/dL) was present in 3 of 12 (25%) of the acute kidney injury subjects versus none of the subjects without acute kidney injury, although this result did not meet statistical significance. Conclusions We provide novel data that demonstrate that FGF-23 levels are elevated in acute kidney injury, suggesting that FGF-23 dysregulation occurs in acute kidney injury as well as chronic kidney disease. Further studies are needed to define the short- and long-term clinical effects of dysregulated mineral metabolism in acute kidney injury patients. Chronic Kidney Disease (dpeaa)DE-He213 Acute Kidney Injury (dpeaa)DE-He213 Chronic Kidney Disease Patient (dpeaa)DE-He213 Cinacalcet (dpeaa)DE-He213 Acute Kidney Injury Patient (dpeaa)DE-He213 Hsu, Raymond verfasserin aut Hsu, Chi-yuan verfasserin aut Kordesch, Kristina verfasserin aut Nicasio, Erica verfasserin aut Cortez, Alfredo verfasserin aut McAlpine, Ian verfasserin aut Brady, Sandra verfasserin aut Zhuo, Hanjing verfasserin aut Kangelaris, Kirsten N verfasserin aut Stein, John verfasserin aut Calfee, Carolyn S verfasserin aut Liu, Kathleen D verfasserin aut Enthalten in Annals of intensive care Heidelberg : Springer, 2011 1(2011), 1 vom: 14. Juni (DE-627)664260918 (DE-600)2617094-2 2110-5820 nnns volume:1 year:2011 number:1 day:14 month:06 https://dx.doi.org/10.1186/2110-5820-1-21 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2011 1 14 06
spelling	10.1186/2110-5820-1-21 doi (DE-627)SPR031925731 (SPR)2110-5820-1-21-e DE-627 ger DE-627 rakwb eng 610 ASE Zhang, MaryAnn verfasserin aut FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Fibroblast growth factor-23 (FGF-23), a novel regulator of mineral metabolism, is markedly elevated in chronic kidney disease and has been associated with poor long-term outcomes. However, whether FGF-23 has an analogous role in acute kidney injury is unknown. The goal of this study was to measure FGF-23 levels in critically ill patients with acute kidney injury to determine whether FGF-23 levels were elevated, as in chronic kidney disease. Methods Plasma FGF-23 and intact parathyroid hormone (PTH) levels were measured in 12 patients with acute kidney injury and 8 control subjects. Results FGF-23 levels were significantly higher in acute kidney injury cases than in critically ill subjects without acute kidney injury, with a median FGF-23 level of 1948 RU/mL (interquartile range (IQR), 437-4369) in cases compared with 252 RU/mL (IQR, 65-533) in controls (p = 0.01). No correlations were observed between FGF-23 and severity of acute kidney injury (defined by the Acute Kidney Injury Network criteria); among patients with acute kidney injury, FGF-23 levels were higher in nonsurvivors than survivors (median levels of 4446 RU/mL (IQR, 3455-5443) versus 544 RU/mL (IQR, 390-1948; p = 0.02). Severe hyperparathyroidism (defined as intact PTH >250 mg/dL) was present in 3 of 12 (25%) of the acute kidney injury subjects versus none of the subjects without acute kidney injury, although this result did not meet statistical significance. Conclusions We provide novel data that demonstrate that FGF-23 levels are elevated in acute kidney injury, suggesting that FGF-23 dysregulation occurs in acute kidney injury as well as chronic kidney disease. Further studies are needed to define the short- and long-term clinical effects of dysregulated mineral metabolism in acute kidney injury patients. Chronic Kidney Disease (dpeaa)DE-He213 Acute Kidney Injury (dpeaa)DE-He213 Chronic Kidney Disease Patient (dpeaa)DE-He213 Cinacalcet (dpeaa)DE-He213 Acute Kidney Injury Patient (dpeaa)DE-He213 Hsu, Raymond verfasserin aut Hsu, Chi-yuan verfasserin aut Kordesch, Kristina verfasserin aut Nicasio, Erica verfasserin aut Cortez, Alfredo verfasserin aut McAlpine, Ian verfasserin aut Brady, Sandra verfasserin aut Zhuo, Hanjing verfasserin aut Kangelaris, Kirsten N verfasserin aut Stein, John verfasserin aut Calfee, Carolyn S verfasserin aut Liu, Kathleen D verfasserin aut Enthalten in Annals of intensive care Heidelberg : Springer, 2011 1(2011), 1 vom: 14. Juni (DE-627)664260918 (DE-600)2617094-2 2110-5820 nnns volume:1 year:2011 number:1 day:14 month:06 https://dx.doi.org/10.1186/2110-5820-1-21 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2011 1 14 06
allfields_unstemmed	10.1186/2110-5820-1-21 doi (DE-627)SPR031925731 (SPR)2110-5820-1-21-e DE-627 ger DE-627 rakwb eng 610 ASE Zhang, MaryAnn verfasserin aut FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Fibroblast growth factor-23 (FGF-23), a novel regulator of mineral metabolism, is markedly elevated in chronic kidney disease and has been associated with poor long-term outcomes. However, whether FGF-23 has an analogous role in acute kidney injury is unknown. The goal of this study was to measure FGF-23 levels in critically ill patients with acute kidney injury to determine whether FGF-23 levels were elevated, as in chronic kidney disease. Methods Plasma FGF-23 and intact parathyroid hormone (PTH) levels were measured in 12 patients with acute kidney injury and 8 control subjects. Results FGF-23 levels were significantly higher in acute kidney injury cases than in critically ill subjects without acute kidney injury, with a median FGF-23 level of 1948 RU/mL (interquartile range (IQR), 437-4369) in cases compared with 252 RU/mL (IQR, 65-533) in controls (p = 0.01). No correlations were observed between FGF-23 and severity of acute kidney injury (defined by the Acute Kidney Injury Network criteria); among patients with acute kidney injury, FGF-23 levels were higher in nonsurvivors than survivors (median levels of 4446 RU/mL (IQR, 3455-5443) versus 544 RU/mL (IQR, 390-1948; p = 0.02). Severe hyperparathyroidism (defined as intact PTH >250 mg/dL) was present in 3 of 12 (25%) of the acute kidney injury subjects versus none of the subjects without acute kidney injury, although this result did not meet statistical significance. Conclusions We provide novel data that demonstrate that FGF-23 levels are elevated in acute kidney injury, suggesting that FGF-23 dysregulation occurs in acute kidney injury as well as chronic kidney disease. Further studies are needed to define the short- and long-term clinical effects of dysregulated mineral metabolism in acute kidney injury patients. Chronic Kidney Disease (dpeaa)DE-He213 Acute Kidney Injury (dpeaa)DE-He213 Chronic Kidney Disease Patient (dpeaa)DE-He213 Cinacalcet (dpeaa)DE-He213 Acute Kidney Injury Patient (dpeaa)DE-He213 Hsu, Raymond verfasserin aut Hsu, Chi-yuan verfasserin aut Kordesch, Kristina verfasserin aut Nicasio, Erica verfasserin aut Cortez, Alfredo verfasserin aut McAlpine, Ian verfasserin aut Brady, Sandra verfasserin aut Zhuo, Hanjing verfasserin aut Kangelaris, Kirsten N verfasserin aut Stein, John verfasserin aut Calfee, Carolyn S verfasserin aut Liu, Kathleen D verfasserin aut Enthalten in Annals of intensive care Heidelberg : Springer, 2011 1(2011), 1 vom: 14. Juni (DE-627)664260918 (DE-600)2617094-2 2110-5820 nnns volume:1 year:2011 number:1 day:14 month:06 https://dx.doi.org/10.1186/2110-5820-1-21 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2011 1 14 06
allfieldsGer	10.1186/2110-5820-1-21 doi (DE-627)SPR031925731 (SPR)2110-5820-1-21-e DE-627 ger DE-627 rakwb eng 610 ASE Zhang, MaryAnn verfasserin aut FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Fibroblast growth factor-23 (FGF-23), a novel regulator of mineral metabolism, is markedly elevated in chronic kidney disease and has been associated with poor long-term outcomes. However, whether FGF-23 has an analogous role in acute kidney injury is unknown. The goal of this study was to measure FGF-23 levels in critically ill patients with acute kidney injury to determine whether FGF-23 levels were elevated, as in chronic kidney disease. Methods Plasma FGF-23 and intact parathyroid hormone (PTH) levels were measured in 12 patients with acute kidney injury and 8 control subjects. Results FGF-23 levels were significantly higher in acute kidney injury cases than in critically ill subjects without acute kidney injury, with a median FGF-23 level of 1948 RU/mL (interquartile range (IQR), 437-4369) in cases compared with 252 RU/mL (IQR, 65-533) in controls (p = 0.01). No correlations were observed between FGF-23 and severity of acute kidney injury (defined by the Acute Kidney Injury Network criteria); among patients with acute kidney injury, FGF-23 levels were higher in nonsurvivors than survivors (median levels of 4446 RU/mL (IQR, 3455-5443) versus 544 RU/mL (IQR, 390-1948; p = 0.02). Severe hyperparathyroidism (defined as intact PTH >250 mg/dL) was present in 3 of 12 (25%) of the acute kidney injury subjects versus none of the subjects without acute kidney injury, although this result did not meet statistical significance. Conclusions We provide novel data that demonstrate that FGF-23 levels are elevated in acute kidney injury, suggesting that FGF-23 dysregulation occurs in acute kidney injury as well as chronic kidney disease. Further studies are needed to define the short- and long-term clinical effects of dysregulated mineral metabolism in acute kidney injury patients. Chronic Kidney Disease (dpeaa)DE-He213 Acute Kidney Injury (dpeaa)DE-He213 Chronic Kidney Disease Patient (dpeaa)DE-He213 Cinacalcet (dpeaa)DE-He213 Acute Kidney Injury Patient (dpeaa)DE-He213 Hsu, Raymond verfasserin aut Hsu, Chi-yuan verfasserin aut Kordesch, Kristina verfasserin aut Nicasio, Erica verfasserin aut Cortez, Alfredo verfasserin aut McAlpine, Ian verfasserin aut Brady, Sandra verfasserin aut Zhuo, Hanjing verfasserin aut Kangelaris, Kirsten N verfasserin aut Stein, John verfasserin aut Calfee, Carolyn S verfasserin aut Liu, Kathleen D verfasserin aut Enthalten in Annals of intensive care Heidelberg : Springer, 2011 1(2011), 1 vom: 14. Juni (DE-627)664260918 (DE-600)2617094-2 2110-5820 nnns volume:1 year:2011 number:1 day:14 month:06 https://dx.doi.org/10.1186/2110-5820-1-21 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2011 1 14 06
allfieldsSound	10.1186/2110-5820-1-21 doi (DE-627)SPR031925731 (SPR)2110-5820-1-21-e DE-627 ger DE-627 rakwb eng 610 ASE Zhang, MaryAnn verfasserin aut FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Fibroblast growth factor-23 (FGF-23), a novel regulator of mineral metabolism, is markedly elevated in chronic kidney disease and has been associated with poor long-term outcomes. However, whether FGF-23 has an analogous role in acute kidney injury is unknown. The goal of this study was to measure FGF-23 levels in critically ill patients with acute kidney injury to determine whether FGF-23 levels were elevated, as in chronic kidney disease. Methods Plasma FGF-23 and intact parathyroid hormone (PTH) levels were measured in 12 patients with acute kidney injury and 8 control subjects. Results FGF-23 levels were significantly higher in acute kidney injury cases than in critically ill subjects without acute kidney injury, with a median FGF-23 level of 1948 RU/mL (interquartile range (IQR), 437-4369) in cases compared with 252 RU/mL (IQR, 65-533) in controls (p = 0.01). No correlations were observed between FGF-23 and severity of acute kidney injury (defined by the Acute Kidney Injury Network criteria); among patients with acute kidney injury, FGF-23 levels were higher in nonsurvivors than survivors (median levels of 4446 RU/mL (IQR, 3455-5443) versus 544 RU/mL (IQR, 390-1948; p = 0.02). Severe hyperparathyroidism (defined as intact PTH >250 mg/dL) was present in 3 of 12 (25%) of the acute kidney injury subjects versus none of the subjects without acute kidney injury, although this result did not meet statistical significance. Conclusions We provide novel data that demonstrate that FGF-23 levels are elevated in acute kidney injury, suggesting that FGF-23 dysregulation occurs in acute kidney injury as well as chronic kidney disease. Further studies are needed to define the short- and long-term clinical effects of dysregulated mineral metabolism in acute kidney injury patients. Chronic Kidney Disease (dpeaa)DE-He213 Acute Kidney Injury (dpeaa)DE-He213 Chronic Kidney Disease Patient (dpeaa)DE-He213 Cinacalcet (dpeaa)DE-He213 Acute Kidney Injury Patient (dpeaa)DE-He213 Hsu, Raymond verfasserin aut Hsu, Chi-yuan verfasserin aut Kordesch, Kristina verfasserin aut Nicasio, Erica verfasserin aut Cortez, Alfredo verfasserin aut McAlpine, Ian verfasserin aut Brady, Sandra verfasserin aut Zhuo, Hanjing verfasserin aut Kangelaris, Kirsten N verfasserin aut Stein, John verfasserin aut Calfee, Carolyn S verfasserin aut Liu, Kathleen D verfasserin aut Enthalten in Annals of intensive care Heidelberg : Springer, 2011 1(2011), 1 vom: 14. Juni (DE-627)664260918 (DE-600)2617094-2 2110-5820 nnns volume:1 year:2011 number:1 day:14 month:06 https://dx.doi.org/10.1186/2110-5820-1-21 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2011 1 14 06
language	English
source	Enthalten in Annals of intensive care 1(2011), 1 vom: 14. Juni volume:1 year:2011 number:1 day:14 month:06
sourceStr	Enthalten in Annals of intensive care 1(2011), 1 vom: 14. Juni volume:1 year:2011 number:1 day:14 month:06
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Chronic Kidney Disease Acute Kidney Injury Chronic Kidney Disease Patient Cinacalcet Acute Kidney Injury Patient
dewey-raw	610
isfreeaccess_bool	false
container_title	Annals of intensive care
authorswithroles_txt_mv	Zhang, MaryAnn @@aut@@ Hsu, Raymond @@aut@@ Hsu, Chi-yuan @@aut@@ Kordesch, Kristina @@aut@@ Nicasio, Erica @@aut@@ Cortez, Alfredo @@aut@@ McAlpine, Ian @@aut@@ Brady, Sandra @@aut@@ Zhuo, Hanjing @@aut@@ Kangelaris, Kirsten N @@aut@@ Stein, John @@aut@@ Calfee, Carolyn S @@aut@@ Liu, Kathleen D @@aut@@
publishDateDaySort_date	2011-06-14T00:00:00Z
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author	Zhang, MaryAnn
spellingShingle	Zhang, MaryAnn ddc 610 misc Chronic Kidney Disease misc Acute Kidney Injury misc Chronic Kidney Disease Patient misc Cinacalcet misc Acute Kidney Injury Patient FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study
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topic_title	610 ASE FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study Chronic Kidney Disease (dpeaa)DE-He213 Acute Kidney Injury (dpeaa)DE-He213 Chronic Kidney Disease Patient (dpeaa)DE-He213 Cinacalcet (dpeaa)DE-He213 Acute Kidney Injury Patient (dpeaa)DE-He213
topic	ddc 610 misc Chronic Kidney Disease misc Acute Kidney Injury misc Chronic Kidney Disease Patient misc Cinacalcet misc Acute Kidney Injury Patient
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title	FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study
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title_full	FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study
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author_browse	Zhang, MaryAnn Hsu, Raymond Hsu, Chi-yuan Kordesch, Kristina Nicasio, Erica Cortez, Alfredo McAlpine, Ian Brady, Sandra Zhuo, Hanjing Kangelaris, Kirsten N Stein, John Calfee, Carolyn S Liu, Kathleen D
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title_sort	fgf-23 and pth levels in patients with acute kidney injury: a cross-sectional case series study
title_auth	FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study
abstract	Background Fibroblast growth factor-23 (FGF-23), a novel regulator of mineral metabolism, is markedly elevated in chronic kidney disease and has been associated with poor long-term outcomes. However, whether FGF-23 has an analogous role in acute kidney injury is unknown. The goal of this study was to measure FGF-23 levels in critically ill patients with acute kidney injury to determine whether FGF-23 levels were elevated, as in chronic kidney disease. Methods Plasma FGF-23 and intact parathyroid hormone (PTH) levels were measured in 12 patients with acute kidney injury and 8 control subjects. Results FGF-23 levels were significantly higher in acute kidney injury cases than in critically ill subjects without acute kidney injury, with a median FGF-23 level of 1948 RU/mL (interquartile range (IQR), 437-4369) in cases compared with 252 RU/mL (IQR, 65-533) in controls (p = 0.01). No correlations were observed between FGF-23 and severity of acute kidney injury (defined by the Acute Kidney Injury Network criteria); among patients with acute kidney injury, FGF-23 levels were higher in nonsurvivors than survivors (median levels of 4446 RU/mL (IQR, 3455-5443) versus 544 RU/mL (IQR, 390-1948; p = 0.02). Severe hyperparathyroidism (defined as intact PTH >250 mg/dL) was present in 3 of 12 (25%) of the acute kidney injury subjects versus none of the subjects without acute kidney injury, although this result did not meet statistical significance. Conclusions We provide novel data that demonstrate that FGF-23 levels are elevated in acute kidney injury, suggesting that FGF-23 dysregulation occurs in acute kidney injury as well as chronic kidney disease. Further studies are needed to define the short- and long-term clinical effects of dysregulated mineral metabolism in acute kidney injury patients.
abstractGer	Background Fibroblast growth factor-23 (FGF-23), a novel regulator of mineral metabolism, is markedly elevated in chronic kidney disease and has been associated with poor long-term outcomes. However, whether FGF-23 has an analogous role in acute kidney injury is unknown. The goal of this study was to measure FGF-23 levels in critically ill patients with acute kidney injury to determine whether FGF-23 levels were elevated, as in chronic kidney disease. Methods Plasma FGF-23 and intact parathyroid hormone (PTH) levels were measured in 12 patients with acute kidney injury and 8 control subjects. Results FGF-23 levels were significantly higher in acute kidney injury cases than in critically ill subjects without acute kidney injury, with a median FGF-23 level of 1948 RU/mL (interquartile range (IQR), 437-4369) in cases compared with 252 RU/mL (IQR, 65-533) in controls (p = 0.01). No correlations were observed between FGF-23 and severity of acute kidney injury (defined by the Acute Kidney Injury Network criteria); among patients with acute kidney injury, FGF-23 levels were higher in nonsurvivors than survivors (median levels of 4446 RU/mL (IQR, 3455-5443) versus 544 RU/mL (IQR, 390-1948; p = 0.02). Severe hyperparathyroidism (defined as intact PTH >250 mg/dL) was present in 3 of 12 (25%) of the acute kidney injury subjects versus none of the subjects without acute kidney injury, although this result did not meet statistical significance. Conclusions We provide novel data that demonstrate that FGF-23 levels are elevated in acute kidney injury, suggesting that FGF-23 dysregulation occurs in acute kidney injury as well as chronic kidney disease. Further studies are needed to define the short- and long-term clinical effects of dysregulated mineral metabolism in acute kidney injury patients.
abstract_unstemmed	Background Fibroblast growth factor-23 (FGF-23), a novel regulator of mineral metabolism, is markedly elevated in chronic kidney disease and has been associated with poor long-term outcomes. However, whether FGF-23 has an analogous role in acute kidney injury is unknown. The goal of this study was to measure FGF-23 levels in critically ill patients with acute kidney injury to determine whether FGF-23 levels were elevated, as in chronic kidney disease. Methods Plasma FGF-23 and intact parathyroid hormone (PTH) levels were measured in 12 patients with acute kidney injury and 8 control subjects. Results FGF-23 levels were significantly higher in acute kidney injury cases than in critically ill subjects without acute kidney injury, with a median FGF-23 level of 1948 RU/mL (interquartile range (IQR), 437-4369) in cases compared with 252 RU/mL (IQR, 65-533) in controls (p = 0.01). No correlations were observed between FGF-23 and severity of acute kidney injury (defined by the Acute Kidney Injury Network criteria); among patients with acute kidney injury, FGF-23 levels were higher in nonsurvivors than survivors (median levels of 4446 RU/mL (IQR, 3455-5443) versus 544 RU/mL (IQR, 390-1948; p = 0.02). Severe hyperparathyroidism (defined as intact PTH >250 mg/dL) was present in 3 of 12 (25%) of the acute kidney injury subjects versus none of the subjects without acute kidney injury, although this result did not meet statistical significance. Conclusions We provide novel data that demonstrate that FGF-23 levels are elevated in acute kidney injury, suggesting that FGF-23 dysregulation occurs in acute kidney injury as well as chronic kidney disease. Further studies are needed to define the short- and long-term clinical effects of dysregulated mineral metabolism in acute kidney injury patients.
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title_short	FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study
url	https://dx.doi.org/10.1186/2110-5820-1-21
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author2	Hsu, Raymond Hsu, Chi-yuan Kordesch, Kristina Nicasio, Erica Cortez, Alfredo McAlpine, Ian Brady, Sandra Zhuo, Hanjing Kangelaris, Kirsten N Stein, John Calfee, Carolyn S Liu, Kathleen D
author2Str	Hsu, Raymond Hsu, Chi-yuan Kordesch, Kristina Nicasio, Erica Cortez, Alfredo McAlpine, Ian Brady, Sandra Zhuo, Hanjing Kangelaris, Kirsten N Stein, John Calfee, Carolyn S Liu, Kathleen D
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