Assessment of renal hemodynamic toxicity of fluid challenge with 0.9% NaCl compared to balanced crystalloid ($ PlasmaLyte^{®} $) in a rat model with severe sepsis
Background According to international guidelines, volume expansion with crystalloids is the first-line treatment for hemodynamic management in patients with severe sepsis or septic shock. Compared to balanced crystalloids, 0.9% sodium chloride (0.9% NaCl) induces hyperchloremia and metabolic acidosi...
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| Autor*in: |
Olivier, Pierre-Yves [verfasserIn] Beloncle, François [verfasserIn] Seegers, Valérie [verfasserIn] Tabka, Maher [verfasserIn] Renou de La Bourdonnaye, Mathilde [verfasserIn] Mercat, Alain [verfasserIn] Cales, Paul [verfasserIn] Henrion, Daniel [verfasserIn] Radermacher, Peter [verfasserIn] Piquilloud, Lise [verfasserIn] Lerolle, Nicolas [verfasserIn] Asfar, Pierre [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Übergeordnetes Werk: |
Enthalten in: Annals of intensive care - Heidelberg : Springer, 2011, 7(2017), 1 vom: 14. Juni |
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| Übergeordnetes Werk: |
volume:7 ; year:2017 ; number:1 ; day:14 ; month:06 |
| Links: |
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| DOI / URN: |
10.1186/s13613-017-0286-1 |
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| Katalog-ID: |
SPR031930514 |
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| 245 | 1 | 0 | |a Assessment of renal hemodynamic toxicity of fluid challenge with 0.9% NaCl compared to balanced crystalloid ($ PlasmaLyte^{®} $) in a rat model with severe sepsis |
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| 520 | |a Background According to international guidelines, volume expansion with crystalloids is the first-line treatment for hemodynamic management in patients with severe sepsis or septic shock. Compared to balanced crystalloids, 0.9% sodium chloride (0.9% NaCl) induces hyperchloremia and metabolic acidosis and may alter renal hemodynamics and function. We compared the effects of 0.9% NaCl to a less chloride-concentrated fluid, $ PlasmaLyte^{®} $ (PL) in targeted fluid resuscitation in a randomized, double-blind controlled study in an experimental model of severe sepsis in rats. Results A sepsis with hypotension was induced by cecal ligature and puncture (CLP) in 40 male Wistar rats (20 for each crystalloid). Rats received fluid resuscitation over a period of 200 min for a targeted mean arterial pressure of 90 mm Hg. Animals received similar volumes of 0.9% NaCl or PL. Unlike PL-resuscitated rats, 0.9% NaCl-resuscitated rats experienced hyperchloremia and metabolic acidosis, whereas systemic hemodynamics, renal hemodynamics and renal function were not significantly different between both groups. Conclusion In our model of rats with severe sepsis resuscitated with large amounts of crystalloids, 0.9% NaCl-induced hyperchloremic acidosis, but balanced crystalloid did not improve systemic and renal hemodynamics or renal function. | ||
| 650 | 4 | |a Sepsis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Shock |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Acute kidney injury |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Hemodynamics |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Microcirculation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Sodium chloride |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a PlasmaLyte |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Crystalloid |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Balanced crystalloid |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Beloncle, François |e verfasserin |4 aut | |
| 700 | 1 | |a Seegers, Valérie |e verfasserin |4 aut | |
| 700 | 1 | |a Tabka, Maher |e verfasserin |4 aut | |
| 700 | 1 | |a Renou de La Bourdonnaye, Mathilde |e verfasserin |4 aut | |
| 700 | 1 | |a Mercat, Alain |e verfasserin |4 aut | |
| 700 | 1 | |a Cales, Paul |e verfasserin |4 aut | |
| 700 | 1 | |a Henrion, Daniel |e verfasserin |4 aut | |
| 700 | 1 | |a Radermacher, Peter |e verfasserin |4 aut | |
| 700 | 1 | |a Piquilloud, Lise |e verfasserin |4 aut | |
| 700 | 1 | |a Lerolle, Nicolas |e verfasserin |4 aut | |
| 700 | 1 | |a Asfar, Pierre |e verfasserin |4 aut | |
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10.1186/s13613-017-0286-1 doi (DE-627)SPR031930514 (SPR)s13613-017-0286-1-e DE-627 ger DE-627 rakwb eng 610 ASE Olivier, Pierre-Yves verfasserin aut Assessment of renal hemodynamic toxicity of fluid challenge with 0.9% NaCl compared to balanced crystalloid ($ PlasmaLyte^{®} $) in a rat model with severe sepsis 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background According to international guidelines, volume expansion with crystalloids is the first-line treatment for hemodynamic management in patients with severe sepsis or septic shock. Compared to balanced crystalloids, 0.9% sodium chloride (0.9% NaCl) induces hyperchloremia and metabolic acidosis and may alter renal hemodynamics and function. We compared the effects of 0.9% NaCl to a less chloride-concentrated fluid, $ PlasmaLyte^{®} $ (PL) in targeted fluid resuscitation in a randomized, double-blind controlled study in an experimental model of severe sepsis in rats. Results A sepsis with hypotension was induced by cecal ligature and puncture (CLP) in 40 male Wistar rats (20 for each crystalloid). Rats received fluid resuscitation over a period of 200 min for a targeted mean arterial pressure of 90 mm Hg. Animals received similar volumes of 0.9% NaCl or PL. Unlike PL-resuscitated rats, 0.9% NaCl-resuscitated rats experienced hyperchloremia and metabolic acidosis, whereas systemic hemodynamics, renal hemodynamics and renal function were not significantly different between both groups. Conclusion In our model of rats with severe sepsis resuscitated with large amounts of crystalloids, 0.9% NaCl-induced hyperchloremic acidosis, but balanced crystalloid did not improve systemic and renal hemodynamics or renal function. Sepsis (dpeaa)DE-He213 Shock (dpeaa)DE-He213 Acute kidney injury (dpeaa)DE-He213 Hemodynamics (dpeaa)DE-He213 Microcirculation (dpeaa)DE-He213 Sodium chloride (dpeaa)DE-He213 PlasmaLyte (dpeaa)DE-He213 Crystalloid (dpeaa)DE-He213 Balanced crystalloid (dpeaa)DE-He213 Beloncle, François verfasserin aut Seegers, Valérie verfasserin aut Tabka, Maher verfasserin aut Renou de La Bourdonnaye, Mathilde verfasserin aut Mercat, Alain verfasserin aut Cales, Paul verfasserin aut Henrion, Daniel verfasserin aut Radermacher, Peter verfasserin aut Piquilloud, Lise verfasserin aut Lerolle, Nicolas verfasserin aut Asfar, Pierre verfasserin aut Enthalten in Annals of intensive care Heidelberg : Springer, 2011 7(2017), 1 vom: 14. Juni (DE-627)664260918 (DE-600)2617094-2 2110-5820 nnns volume:7 year:2017 number:1 day:14 month:06 https://dx.doi.org/10.1186/s13613-017-0286-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2017 1 14 06 |
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10.1186/s13613-017-0286-1 doi (DE-627)SPR031930514 (SPR)s13613-017-0286-1-e DE-627 ger DE-627 rakwb eng 610 ASE Olivier, Pierre-Yves verfasserin aut Assessment of renal hemodynamic toxicity of fluid challenge with 0.9% NaCl compared to balanced crystalloid ($ PlasmaLyte^{®} $) in a rat model with severe sepsis 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background According to international guidelines, volume expansion with crystalloids is the first-line treatment for hemodynamic management in patients with severe sepsis or septic shock. Compared to balanced crystalloids, 0.9% sodium chloride (0.9% NaCl) induces hyperchloremia and metabolic acidosis and may alter renal hemodynamics and function. We compared the effects of 0.9% NaCl to a less chloride-concentrated fluid, $ PlasmaLyte^{®} $ (PL) in targeted fluid resuscitation in a randomized, double-blind controlled study in an experimental model of severe sepsis in rats. Results A sepsis with hypotension was induced by cecal ligature and puncture (CLP) in 40 male Wistar rats (20 for each crystalloid). Rats received fluid resuscitation over a period of 200 min for a targeted mean arterial pressure of 90 mm Hg. Animals received similar volumes of 0.9% NaCl or PL. Unlike PL-resuscitated rats, 0.9% NaCl-resuscitated rats experienced hyperchloremia and metabolic acidosis, whereas systemic hemodynamics, renal hemodynamics and renal function were not significantly different between both groups. Conclusion In our model of rats with severe sepsis resuscitated with large amounts of crystalloids, 0.9% NaCl-induced hyperchloremic acidosis, but balanced crystalloid did not improve systemic and renal hemodynamics or renal function. Sepsis (dpeaa)DE-He213 Shock (dpeaa)DE-He213 Acute kidney injury (dpeaa)DE-He213 Hemodynamics (dpeaa)DE-He213 Microcirculation (dpeaa)DE-He213 Sodium chloride (dpeaa)DE-He213 PlasmaLyte (dpeaa)DE-He213 Crystalloid (dpeaa)DE-He213 Balanced crystalloid (dpeaa)DE-He213 Beloncle, François verfasserin aut Seegers, Valérie verfasserin aut Tabka, Maher verfasserin aut Renou de La Bourdonnaye, Mathilde verfasserin aut Mercat, Alain verfasserin aut Cales, Paul verfasserin aut Henrion, Daniel verfasserin aut Radermacher, Peter verfasserin aut Piquilloud, Lise verfasserin aut Lerolle, Nicolas verfasserin aut Asfar, Pierre verfasserin aut Enthalten in Annals of intensive care Heidelberg : Springer, 2011 7(2017), 1 vom: 14. Juni (DE-627)664260918 (DE-600)2617094-2 2110-5820 nnns volume:7 year:2017 number:1 day:14 month:06 https://dx.doi.org/10.1186/s13613-017-0286-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2017 1 14 06 |
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10.1186/s13613-017-0286-1 doi (DE-627)SPR031930514 (SPR)s13613-017-0286-1-e DE-627 ger DE-627 rakwb eng 610 ASE Olivier, Pierre-Yves verfasserin aut Assessment of renal hemodynamic toxicity of fluid challenge with 0.9% NaCl compared to balanced crystalloid ($ PlasmaLyte^{®} $) in a rat model with severe sepsis 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background According to international guidelines, volume expansion with crystalloids is the first-line treatment for hemodynamic management in patients with severe sepsis or septic shock. Compared to balanced crystalloids, 0.9% sodium chloride (0.9% NaCl) induces hyperchloremia and metabolic acidosis and may alter renal hemodynamics and function. We compared the effects of 0.9% NaCl to a less chloride-concentrated fluid, $ PlasmaLyte^{®} $ (PL) in targeted fluid resuscitation in a randomized, double-blind controlled study in an experimental model of severe sepsis in rats. Results A sepsis with hypotension was induced by cecal ligature and puncture (CLP) in 40 male Wistar rats (20 for each crystalloid). Rats received fluid resuscitation over a period of 200 min for a targeted mean arterial pressure of 90 mm Hg. Animals received similar volumes of 0.9% NaCl or PL. Unlike PL-resuscitated rats, 0.9% NaCl-resuscitated rats experienced hyperchloremia and metabolic acidosis, whereas systemic hemodynamics, renal hemodynamics and renal function were not significantly different between both groups. Conclusion In our model of rats with severe sepsis resuscitated with large amounts of crystalloids, 0.9% NaCl-induced hyperchloremic acidosis, but balanced crystalloid did not improve systemic and renal hemodynamics or renal function. Sepsis (dpeaa)DE-He213 Shock (dpeaa)DE-He213 Acute kidney injury (dpeaa)DE-He213 Hemodynamics (dpeaa)DE-He213 Microcirculation (dpeaa)DE-He213 Sodium chloride (dpeaa)DE-He213 PlasmaLyte (dpeaa)DE-He213 Crystalloid (dpeaa)DE-He213 Balanced crystalloid (dpeaa)DE-He213 Beloncle, François verfasserin aut Seegers, Valérie verfasserin aut Tabka, Maher verfasserin aut Renou de La Bourdonnaye, Mathilde verfasserin aut Mercat, Alain verfasserin aut Cales, Paul verfasserin aut Henrion, Daniel verfasserin aut Radermacher, Peter verfasserin aut Piquilloud, Lise verfasserin aut Lerolle, Nicolas verfasserin aut Asfar, Pierre verfasserin aut Enthalten in Annals of intensive care Heidelberg : Springer, 2011 7(2017), 1 vom: 14. Juni (DE-627)664260918 (DE-600)2617094-2 2110-5820 nnns volume:7 year:2017 number:1 day:14 month:06 https://dx.doi.org/10.1186/s13613-017-0286-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2017 1 14 06 |
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10.1186/s13613-017-0286-1 doi (DE-627)SPR031930514 (SPR)s13613-017-0286-1-e DE-627 ger DE-627 rakwb eng 610 ASE Olivier, Pierre-Yves verfasserin aut Assessment of renal hemodynamic toxicity of fluid challenge with 0.9% NaCl compared to balanced crystalloid ($ PlasmaLyte^{®} $) in a rat model with severe sepsis 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background According to international guidelines, volume expansion with crystalloids is the first-line treatment for hemodynamic management in patients with severe sepsis or septic shock. Compared to balanced crystalloids, 0.9% sodium chloride (0.9% NaCl) induces hyperchloremia and metabolic acidosis and may alter renal hemodynamics and function. We compared the effects of 0.9% NaCl to a less chloride-concentrated fluid, $ PlasmaLyte^{®} $ (PL) in targeted fluid resuscitation in a randomized, double-blind controlled study in an experimental model of severe sepsis in rats. Results A sepsis with hypotension was induced by cecal ligature and puncture (CLP) in 40 male Wistar rats (20 for each crystalloid). Rats received fluid resuscitation over a period of 200 min for a targeted mean arterial pressure of 90 mm Hg. Animals received similar volumes of 0.9% NaCl or PL. Unlike PL-resuscitated rats, 0.9% NaCl-resuscitated rats experienced hyperchloremia and metabolic acidosis, whereas systemic hemodynamics, renal hemodynamics and renal function were not significantly different between both groups. Conclusion In our model of rats with severe sepsis resuscitated with large amounts of crystalloids, 0.9% NaCl-induced hyperchloremic acidosis, but balanced crystalloid did not improve systemic and renal hemodynamics or renal function. Sepsis (dpeaa)DE-He213 Shock (dpeaa)DE-He213 Acute kidney injury (dpeaa)DE-He213 Hemodynamics (dpeaa)DE-He213 Microcirculation (dpeaa)DE-He213 Sodium chloride (dpeaa)DE-He213 PlasmaLyte (dpeaa)DE-He213 Crystalloid (dpeaa)DE-He213 Balanced crystalloid (dpeaa)DE-He213 Beloncle, François verfasserin aut Seegers, Valérie verfasserin aut Tabka, Maher verfasserin aut Renou de La Bourdonnaye, Mathilde verfasserin aut Mercat, Alain verfasserin aut Cales, Paul verfasserin aut Henrion, Daniel verfasserin aut Radermacher, Peter verfasserin aut Piquilloud, Lise verfasserin aut Lerolle, Nicolas verfasserin aut Asfar, Pierre verfasserin aut Enthalten in Annals of intensive care Heidelberg : Springer, 2011 7(2017), 1 vom: 14. Juni (DE-627)664260918 (DE-600)2617094-2 2110-5820 nnns volume:7 year:2017 number:1 day:14 month:06 https://dx.doi.org/10.1186/s13613-017-0286-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2017 1 14 06 |
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10.1186/s13613-017-0286-1 doi (DE-627)SPR031930514 (SPR)s13613-017-0286-1-e DE-627 ger DE-627 rakwb eng 610 ASE Olivier, Pierre-Yves verfasserin aut Assessment of renal hemodynamic toxicity of fluid challenge with 0.9% NaCl compared to balanced crystalloid ($ PlasmaLyte^{®} $) in a rat model with severe sepsis 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background According to international guidelines, volume expansion with crystalloids is the first-line treatment for hemodynamic management in patients with severe sepsis or septic shock. Compared to balanced crystalloids, 0.9% sodium chloride (0.9% NaCl) induces hyperchloremia and metabolic acidosis and may alter renal hemodynamics and function. We compared the effects of 0.9% NaCl to a less chloride-concentrated fluid, $ PlasmaLyte^{®} $ (PL) in targeted fluid resuscitation in a randomized, double-blind controlled study in an experimental model of severe sepsis in rats. Results A sepsis with hypotension was induced by cecal ligature and puncture (CLP) in 40 male Wistar rats (20 for each crystalloid). Rats received fluid resuscitation over a period of 200 min for a targeted mean arterial pressure of 90 mm Hg. Animals received similar volumes of 0.9% NaCl or PL. Unlike PL-resuscitated rats, 0.9% NaCl-resuscitated rats experienced hyperchloremia and metabolic acidosis, whereas systemic hemodynamics, renal hemodynamics and renal function were not significantly different between both groups. Conclusion In our model of rats with severe sepsis resuscitated with large amounts of crystalloids, 0.9% NaCl-induced hyperchloremic acidosis, but balanced crystalloid did not improve systemic and renal hemodynamics or renal function. Sepsis (dpeaa)DE-He213 Shock (dpeaa)DE-He213 Acute kidney injury (dpeaa)DE-He213 Hemodynamics (dpeaa)DE-He213 Microcirculation (dpeaa)DE-He213 Sodium chloride (dpeaa)DE-He213 PlasmaLyte (dpeaa)DE-He213 Crystalloid (dpeaa)DE-He213 Balanced crystalloid (dpeaa)DE-He213 Beloncle, François verfasserin aut Seegers, Valérie verfasserin aut Tabka, Maher verfasserin aut Renou de La Bourdonnaye, Mathilde verfasserin aut Mercat, Alain verfasserin aut Cales, Paul verfasserin aut Henrion, Daniel verfasserin aut Radermacher, Peter verfasserin aut Piquilloud, Lise verfasserin aut Lerolle, Nicolas verfasserin aut Asfar, Pierre verfasserin aut Enthalten in Annals of intensive care Heidelberg : Springer, 2011 7(2017), 1 vom: 14. Juni (DE-627)664260918 (DE-600)2617094-2 2110-5820 nnns volume:7 year:2017 number:1 day:14 month:06 https://dx.doi.org/10.1186/s13613-017-0286-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2017 1 14 06 |
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Olivier, Pierre-Yves Beloncle, François Seegers, Valérie Tabka, Maher Renou de La Bourdonnaye, Mathilde Mercat, Alain Cales, Paul Henrion, Daniel Radermacher, Peter Piquilloud, Lise Lerolle, Nicolas Asfar, Pierre |
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assessment of renal hemodynamic toxicity of fluid challenge with 0.9% nacl compared to balanced crystalloid ($ plasmalyte^{®} $) in a rat model with severe sepsis |
| title_auth |
Assessment of renal hemodynamic toxicity of fluid challenge with 0.9% NaCl compared to balanced crystalloid ($ PlasmaLyte^{®} $) in a rat model with severe sepsis |
| abstract |
Background According to international guidelines, volume expansion with crystalloids is the first-line treatment for hemodynamic management in patients with severe sepsis or septic shock. Compared to balanced crystalloids, 0.9% sodium chloride (0.9% NaCl) induces hyperchloremia and metabolic acidosis and may alter renal hemodynamics and function. We compared the effects of 0.9% NaCl to a less chloride-concentrated fluid, $ PlasmaLyte^{®} $ (PL) in targeted fluid resuscitation in a randomized, double-blind controlled study in an experimental model of severe sepsis in rats. Results A sepsis with hypotension was induced by cecal ligature and puncture (CLP) in 40 male Wistar rats (20 for each crystalloid). Rats received fluid resuscitation over a period of 200 min for a targeted mean arterial pressure of 90 mm Hg. Animals received similar volumes of 0.9% NaCl or PL. Unlike PL-resuscitated rats, 0.9% NaCl-resuscitated rats experienced hyperchloremia and metabolic acidosis, whereas systemic hemodynamics, renal hemodynamics and renal function were not significantly different between both groups. Conclusion In our model of rats with severe sepsis resuscitated with large amounts of crystalloids, 0.9% NaCl-induced hyperchloremic acidosis, but balanced crystalloid did not improve systemic and renal hemodynamics or renal function. |
| abstractGer |
Background According to international guidelines, volume expansion with crystalloids is the first-line treatment for hemodynamic management in patients with severe sepsis or septic shock. Compared to balanced crystalloids, 0.9% sodium chloride (0.9% NaCl) induces hyperchloremia and metabolic acidosis and may alter renal hemodynamics and function. We compared the effects of 0.9% NaCl to a less chloride-concentrated fluid, $ PlasmaLyte^{®} $ (PL) in targeted fluid resuscitation in a randomized, double-blind controlled study in an experimental model of severe sepsis in rats. Results A sepsis with hypotension was induced by cecal ligature and puncture (CLP) in 40 male Wistar rats (20 for each crystalloid). Rats received fluid resuscitation over a period of 200 min for a targeted mean arterial pressure of 90 mm Hg. Animals received similar volumes of 0.9% NaCl or PL. Unlike PL-resuscitated rats, 0.9% NaCl-resuscitated rats experienced hyperchloremia and metabolic acidosis, whereas systemic hemodynamics, renal hemodynamics and renal function were not significantly different between both groups. Conclusion In our model of rats with severe sepsis resuscitated with large amounts of crystalloids, 0.9% NaCl-induced hyperchloremic acidosis, but balanced crystalloid did not improve systemic and renal hemodynamics or renal function. |
| abstract_unstemmed |
Background According to international guidelines, volume expansion with crystalloids is the first-line treatment for hemodynamic management in patients with severe sepsis or septic shock. Compared to balanced crystalloids, 0.9% sodium chloride (0.9% NaCl) induces hyperchloremia and metabolic acidosis and may alter renal hemodynamics and function. We compared the effects of 0.9% NaCl to a less chloride-concentrated fluid, $ PlasmaLyte^{®} $ (PL) in targeted fluid resuscitation in a randomized, double-blind controlled study in an experimental model of severe sepsis in rats. Results A sepsis with hypotension was induced by cecal ligature and puncture (CLP) in 40 male Wistar rats (20 for each crystalloid). Rats received fluid resuscitation over a period of 200 min for a targeted mean arterial pressure of 90 mm Hg. Animals received similar volumes of 0.9% NaCl or PL. Unlike PL-resuscitated rats, 0.9% NaCl-resuscitated rats experienced hyperchloremia and metabolic acidosis, whereas systemic hemodynamics, renal hemodynamics and renal function were not significantly different between both groups. Conclusion In our model of rats with severe sepsis resuscitated with large amounts of crystalloids, 0.9% NaCl-induced hyperchloremic acidosis, but balanced crystalloid did not improve systemic and renal hemodynamics or renal function. |
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Assessment of renal hemodynamic toxicity of fluid challenge with 0.9% NaCl compared to balanced crystalloid ($ PlasmaLyte^{®} $) in a rat model with severe sepsis |
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Beloncle, François Seegers, Valérie Tabka, Maher Renou de La Bourdonnaye, Mathilde Mercat, Alain Cales, Paul Henrion, Daniel Radermacher, Peter Piquilloud, Lise Lerolle, Nicolas Asfar, Pierre |
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