Synthesis, Characterization, Hydrolytic Degradation and Mathematical Modeling of Poly[bis(2(2-methoxyethoxyethoxy diethylamino)phosphazene]
Abstract The use of polymer-based polyphosphazene is increasing in biomedical industry due to their degradable nature, and their specific role can further be tailored by substituting the chloro groups in the linear precursor with suitable nucleophiles. In this study, we aimed to synthesize a novel d...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Amin, Abid M. [verfasserIn] Intisar, Azeem [verfasserIn] Hussain, Habib [verfasserIn] Ali, Zulfiqar [verfasserIn] Naz, Asma [verfasserIn] Hussain, Shabbir [verfasserIn] Shahzady, Tanzeela G. [verfasserIn] Waqas, Muhammad [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2019 |
|---|
| Schlagwörter: |
|---|
| Übergeordnetes Werk: |
Enthalten in: The Arabian journal for science and engineering - Berlin : Springer, 2011, 45(2019), 1 vom: 10. Dez., Seite 241-247 |
|---|---|
| Übergeordnetes Werk: |
volume:45 ; year:2019 ; number:1 ; day:10 ; month:12 ; pages:241-247 |
| Links: |
|---|
| DOI / URN: |
10.1007/s13369-019-04278-8 |
|---|
| Katalog-ID: |
SPR03207736X |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | SPR03207736X | ||
| 003 | DE-627 | ||
| 005 | 20230519142235.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 201007s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s13369-019-04278-8 |2 doi | |
| 035 | |a (DE-627)SPR03207736X | ||
| 035 | |a (SPR)s13369-019-04278-8-e | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 600 |a 500 |q ASE |
| 084 | |a 31.00 |2 bkl | ||
| 100 | 1 | |a Amin, Abid M. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Synthesis, Characterization, Hydrolytic Degradation and Mathematical Modeling of Poly[bis(2(2-methoxyethoxyethoxy diethylamino)phosphazene] |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Abstract The use of polymer-based polyphosphazene is increasing in biomedical industry due to their degradable nature, and their specific role can further be tailored by substituting the chloro groups in the linear precursor with suitable nucleophiles. In this study, we aimed to synthesize a novel degradable polymer based on polyphosphazene by derivatizing the linear poly(dichlorophosphazene) precursor with diethyl amine and 2-(2-methoxyethoxy)ethanol. The structure of the synthesized polymer, poly[bis(2(2-methoxyethoxyethoxy diethylamino)phosphazene] (PMEEDEAP) was elucidated with 1H NMR and 31P NMR. The molar mass distribution and molecular weight of the synthesized polymers were assessed by employing GPC. The hydrolytic degradation, in vitro, of the polymer was carried out in phosphate-buffered saline (PBS) with pH ~ 7.0 and at 37 °C. The polymer showed a weight loss of 95% in 5 weeks. Current studies showed that the synthesized degradable polymer may further be subjected to in vivo studies and employed as a potential candidate for biomedical applications, i.e., controlled-drug delivery and tissue engineering. In addition, the experimental data were analyzed by graphical and statistical methods, and it was found that the weight loss of PMEEDEAP is linear function of time, i.e., %$ w_{t} = - 1 \times 10^{-3} \;t_{{\text{hr}}} + 1.068. %$ The value of the coefficient of determination (R2) is found to be 0.978, which indicates that the workability of the model is good. | ||
| 650 | 4 | |a Polyphosphazenes |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Synthesis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Properties |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Hydrolytic degradation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Mathematical model |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Intisar, Azeem |e verfasserin |4 aut | |
| 700 | 1 | |a Hussain, Habib |e verfasserin |4 aut | |
| 700 | 1 | |a Ali, Zulfiqar |e verfasserin |4 aut | |
| 700 | 1 | |a Naz, Asma |e verfasserin |4 aut | |
| 700 | 1 | |a Hussain, Shabbir |e verfasserin |4 aut | |
| 700 | 1 | |a Shahzady, Tanzeela G. |e verfasserin |4 aut | |
| 700 | 1 | |a Waqas, Muhammad |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The Arabian journal for science and engineering |d Berlin : Springer, 2011 |g 45(2019), 1 vom: 10. Dez., Seite 241-247 |w (DE-627)588780731 |w (DE-600)2471504-9 |x 2191-4281 |7 nnns |
| 773 | 1 | 8 | |g volume:45 |g year:2019 |g number:1 |g day:10 |g month:12 |g pages:241-247 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1007/s13369-019-04278-8 |z lizenzpflichtig |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_SPRINGER | ||
| 912 | |a SSG-OLC-PHA | ||
| 912 | |a GBV_ILN_11 | ||
| 912 | |a GBV_ILN_20 | ||
| 912 | |a GBV_ILN_22 | ||
| 912 | |a GBV_ILN_23 | ||
| 912 | |a GBV_ILN_24 | ||
| 912 | |a GBV_ILN_31 | ||
| 912 | |a GBV_ILN_32 | ||
| 912 | |a GBV_ILN_39 | ||
| 912 | |a GBV_ILN_40 | ||
| 912 | |a GBV_ILN_60 | ||
| 912 | |a GBV_ILN_62 | ||
| 912 | |a GBV_ILN_63 | ||
| 912 | |a GBV_ILN_65 | ||
| 912 | |a GBV_ILN_69 | ||
| 912 | |a GBV_ILN_70 | ||
| 912 | |a GBV_ILN_73 | ||
| 912 | |a GBV_ILN_74 | ||
| 912 | |a GBV_ILN_90 | ||
| 912 | |a GBV_ILN_95 | ||
| 912 | |a GBV_ILN_100 | ||
| 912 | |a GBV_ILN_105 | ||
| 912 | |a GBV_ILN_110 | ||
| 912 | |a GBV_ILN_120 | ||
| 912 | |a GBV_ILN_138 | ||
| 912 | |a GBV_ILN_150 | ||
| 912 | |a GBV_ILN_151 | ||
| 912 | |a GBV_ILN_152 | ||
| 912 | |a GBV_ILN_161 | ||
| 912 | |a GBV_ILN_170 | ||
| 912 | |a GBV_ILN_171 | ||
| 912 | |a GBV_ILN_187 | ||
| 912 | |a GBV_ILN_213 | ||
| 912 | |a GBV_ILN_224 | ||
| 912 | |a GBV_ILN_230 | ||
| 912 | |a GBV_ILN_250 | ||
| 912 | |a GBV_ILN_281 | ||
| 912 | |a GBV_ILN_285 | ||
| 912 | |a GBV_ILN_293 | ||
| 912 | |a GBV_ILN_370 | ||
| 912 | |a GBV_ILN_602 | ||
| 912 | |a GBV_ILN_636 | ||
| 912 | |a GBV_ILN_702 | ||
| 912 | |a GBV_ILN_2001 | ||
| 912 | |a GBV_ILN_2003 | ||
| 912 | |a GBV_ILN_2004 | ||
| 912 | |a GBV_ILN_2005 | ||
| 912 | |a GBV_ILN_2006 | ||
| 912 | |a GBV_ILN_2007 | ||
| 912 | |a GBV_ILN_2008 | ||
| 912 | |a GBV_ILN_2009 | ||
| 912 | |a GBV_ILN_2010 | ||
| 912 | |a GBV_ILN_2011 | ||
| 912 | |a GBV_ILN_2014 | ||
| 912 | |a GBV_ILN_2015 | ||
| 912 | |a GBV_ILN_2020 | ||
| 912 | |a GBV_ILN_2021 | ||
| 912 | |a GBV_ILN_2025 | ||
| 912 | |a GBV_ILN_2026 | ||
| 912 | |a GBV_ILN_2027 | ||
| 912 | |a GBV_ILN_2031 | ||
| 912 | |a GBV_ILN_2034 | ||
| 912 | |a GBV_ILN_2037 | ||
| 912 | |a GBV_ILN_2038 | ||
| 912 | |a GBV_ILN_2039 | ||
| 912 | |a GBV_ILN_2044 | ||
| 912 | |a GBV_ILN_2048 | ||
| 912 | |a GBV_ILN_2049 | ||
| 912 | |a GBV_ILN_2050 | ||
| 912 | |a GBV_ILN_2055 | ||
| 912 | |a GBV_ILN_2057 | ||
| 912 | |a GBV_ILN_2059 | ||
| 912 | |a GBV_ILN_2061 | ||
| 912 | |a GBV_ILN_2064 | ||
| 912 | |a GBV_ILN_2065 | ||
| 912 | |a GBV_ILN_2068 | ||
| 912 | |a GBV_ILN_2070 | ||
| 912 | |a GBV_ILN_2086 | ||
| 912 | |a GBV_ILN_2088 | ||
| 912 | |a GBV_ILN_2093 | ||
| 912 | |a GBV_ILN_2106 | ||
| 912 | |a GBV_ILN_2107 | ||
| 912 | |a GBV_ILN_2108 | ||
| 912 | |a GBV_ILN_2110 | ||
| 912 | |a GBV_ILN_2111 | ||
| 912 | |a GBV_ILN_2112 | ||
| 912 | |a GBV_ILN_2113 | ||
| 912 | |a GBV_ILN_2116 | ||
| 912 | |a GBV_ILN_2118 | ||
| 912 | |a GBV_ILN_2119 | ||
| 912 | |a GBV_ILN_2122 | ||
| 912 | |a GBV_ILN_2129 | ||
| 912 | |a GBV_ILN_2143 | ||
| 912 | |a GBV_ILN_2144 | ||
| 912 | |a GBV_ILN_2147 | ||
| 912 | |a GBV_ILN_2148 | ||
| 912 | |a GBV_ILN_2152 | ||
| 912 | |a GBV_ILN_2153 | ||
| 912 | |a GBV_ILN_2188 | ||
| 912 | |a GBV_ILN_2232 | ||
| 912 | |a GBV_ILN_2336 | ||
| 912 | |a GBV_ILN_2446 | ||
| 912 | |a GBV_ILN_2470 | ||
| 912 | |a GBV_ILN_2472 | ||
| 912 | |a GBV_ILN_2507 | ||
| 912 | |a GBV_ILN_2522 | ||
| 912 | |a GBV_ILN_2548 | ||
| 912 | |a GBV_ILN_4035 | ||
| 912 | |a GBV_ILN_4037 | ||
| 912 | |a GBV_ILN_4046 | ||
| 912 | |a GBV_ILN_4112 | ||
| 912 | |a GBV_ILN_4125 | ||
| 912 | |a GBV_ILN_4242 | ||
| 912 | |a GBV_ILN_4246 | ||
| 912 | |a GBV_ILN_4249 | ||
| 912 | |a GBV_ILN_4251 | ||
| 912 | |a GBV_ILN_4305 | ||
| 912 | |a GBV_ILN_4306 | ||
| 912 | |a GBV_ILN_4307 | ||
| 912 | |a GBV_ILN_4313 | ||
| 912 | |a GBV_ILN_4322 | ||
| 912 | |a GBV_ILN_4323 | ||
| 912 | |a GBV_ILN_4324 | ||
| 912 | |a GBV_ILN_4325 | ||
| 912 | |a GBV_ILN_4326 | ||
| 912 | |a GBV_ILN_4333 | ||
| 912 | |a GBV_ILN_4334 | ||
| 912 | |a GBV_ILN_4335 | ||
| 912 | |a GBV_ILN_4336 | ||
| 912 | |a GBV_ILN_4338 | ||
| 912 | |a GBV_ILN_4393 | ||
| 912 | |a GBV_ILN_4700 | ||
| 936 | b | k | |a 31.00 |q ASE |
| 951 | |a AR | ||
| 952 | |d 45 |j 2019 |e 1 |b 10 |c 12 |h 241-247 | ||
| author_variant |
a m a am ama a i ai h h hh z a za a n an s h sh t g s tg tgs m w mw |
|---|---|
| matchkey_str |
article:21914281:2019----::yteicaatrztohdoyidgaainnmteaiamdlnoplbs2ehxeh |
| hierarchy_sort_str |
2019 |
| bklnumber |
31.00 |
| publishDate |
2019 |
| allfields |
10.1007/s13369-019-04278-8 doi (DE-627)SPR03207736X (SPR)s13369-019-04278-8-e DE-627 ger DE-627 rakwb eng 600 500 ASE 31.00 bkl Amin, Abid M. verfasserin aut Synthesis, Characterization, Hydrolytic Degradation and Mathematical Modeling of Poly[bis(2(2-methoxyethoxyethoxy diethylamino)phosphazene] 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The use of polymer-based polyphosphazene is increasing in biomedical industry due to their degradable nature, and their specific role can further be tailored by substituting the chloro groups in the linear precursor with suitable nucleophiles. In this study, we aimed to synthesize a novel degradable polymer based on polyphosphazene by derivatizing the linear poly(dichlorophosphazene) precursor with diethyl amine and 2-(2-methoxyethoxy)ethanol. The structure of the synthesized polymer, poly[bis(2(2-methoxyethoxyethoxy diethylamino)phosphazene] (PMEEDEAP) was elucidated with 1H NMR and 31P NMR. The molar mass distribution and molecular weight of the synthesized polymers were assessed by employing GPC. The hydrolytic degradation, in vitro, of the polymer was carried out in phosphate-buffered saline (PBS) with pH ~ 7.0 and at 37 °C. The polymer showed a weight loss of 95% in 5 weeks. Current studies showed that the synthesized degradable polymer may further be subjected to in vivo studies and employed as a potential candidate for biomedical applications, i.e., controlled-drug delivery and tissue engineering. In addition, the experimental data were analyzed by graphical and statistical methods, and it was found that the weight loss of PMEEDEAP is linear function of time, i.e., %$ w_{t} = - 1 \times 10^{-3} \;t_{{\text{hr}}} + 1.068. %$ The value of the coefficient of determination (R2) is found to be 0.978, which indicates that the workability of the model is good. Polyphosphazenes (dpeaa)DE-He213 Synthesis (dpeaa)DE-He213 Properties (dpeaa)DE-He213 Hydrolytic degradation (dpeaa)DE-He213 Mathematical model (dpeaa)DE-He213 Intisar, Azeem verfasserin aut Hussain, Habib verfasserin aut Ali, Zulfiqar verfasserin aut Naz, Asma verfasserin aut Hussain, Shabbir verfasserin aut Shahzady, Tanzeela G. verfasserin aut Waqas, Muhammad verfasserin aut Enthalten in The Arabian journal for science and engineering Berlin : Springer, 2011 45(2019), 1 vom: 10. Dez., Seite 241-247 (DE-627)588780731 (DE-600)2471504-9 2191-4281 nnns volume:45 year:2019 number:1 day:10 month:12 pages:241-247 https://dx.doi.org/10.1007/s13369-019-04278-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 31.00 ASE AR 45 2019 1 10 12 241-247 |
| spelling |
10.1007/s13369-019-04278-8 doi (DE-627)SPR03207736X (SPR)s13369-019-04278-8-e DE-627 ger DE-627 rakwb eng 600 500 ASE 31.00 bkl Amin, Abid M. verfasserin aut Synthesis, Characterization, Hydrolytic Degradation and Mathematical Modeling of Poly[bis(2(2-methoxyethoxyethoxy diethylamino)phosphazene] 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The use of polymer-based polyphosphazene is increasing in biomedical industry due to their degradable nature, and their specific role can further be tailored by substituting the chloro groups in the linear precursor with suitable nucleophiles. In this study, we aimed to synthesize a novel degradable polymer based on polyphosphazene by derivatizing the linear poly(dichlorophosphazene) precursor with diethyl amine and 2-(2-methoxyethoxy)ethanol. The structure of the synthesized polymer, poly[bis(2(2-methoxyethoxyethoxy diethylamino)phosphazene] (PMEEDEAP) was elucidated with 1H NMR and 31P NMR. The molar mass distribution and molecular weight of the synthesized polymers were assessed by employing GPC. The hydrolytic degradation, in vitro, of the polymer was carried out in phosphate-buffered saline (PBS) with pH ~ 7.0 and at 37 °C. The polymer showed a weight loss of 95% in 5 weeks. Current studies showed that the synthesized degradable polymer may further be subjected to in vivo studies and employed as a potential candidate for biomedical applications, i.e., controlled-drug delivery and tissue engineering. In addition, the experimental data were analyzed by graphical and statistical methods, and it was found that the weight loss of PMEEDEAP is linear function of time, i.e., %$ w_{t} = - 1 \times 10^{-3} \;t_{{\text{hr}}} + 1.068. %$ The value of the coefficient of determination (R2) is found to be 0.978, which indicates that the workability of the model is good. Polyphosphazenes (dpeaa)DE-He213 Synthesis (dpeaa)DE-He213 Properties (dpeaa)DE-He213 Hydrolytic degradation (dpeaa)DE-He213 Mathematical model (dpeaa)DE-He213 Intisar, Azeem verfasserin aut Hussain, Habib verfasserin aut Ali, Zulfiqar verfasserin aut Naz, Asma verfasserin aut Hussain, Shabbir verfasserin aut Shahzady, Tanzeela G. verfasserin aut Waqas, Muhammad verfasserin aut Enthalten in The Arabian journal for science and engineering Berlin : Springer, 2011 45(2019), 1 vom: 10. Dez., Seite 241-247 (DE-627)588780731 (DE-600)2471504-9 2191-4281 nnns volume:45 year:2019 number:1 day:10 month:12 pages:241-247 https://dx.doi.org/10.1007/s13369-019-04278-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 31.00 ASE AR 45 2019 1 10 12 241-247 |
| allfields_unstemmed |
10.1007/s13369-019-04278-8 doi (DE-627)SPR03207736X (SPR)s13369-019-04278-8-e DE-627 ger DE-627 rakwb eng 600 500 ASE 31.00 bkl Amin, Abid M. verfasserin aut Synthesis, Characterization, Hydrolytic Degradation and Mathematical Modeling of Poly[bis(2(2-methoxyethoxyethoxy diethylamino)phosphazene] 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The use of polymer-based polyphosphazene is increasing in biomedical industry due to their degradable nature, and their specific role can further be tailored by substituting the chloro groups in the linear precursor with suitable nucleophiles. In this study, we aimed to synthesize a novel degradable polymer based on polyphosphazene by derivatizing the linear poly(dichlorophosphazene) precursor with diethyl amine and 2-(2-methoxyethoxy)ethanol. The structure of the synthesized polymer, poly[bis(2(2-methoxyethoxyethoxy diethylamino)phosphazene] (PMEEDEAP) was elucidated with 1H NMR and 31P NMR. The molar mass distribution and molecular weight of the synthesized polymers were assessed by employing GPC. The hydrolytic degradation, in vitro, of the polymer was carried out in phosphate-buffered saline (PBS) with pH ~ 7.0 and at 37 °C. The polymer showed a weight loss of 95% in 5 weeks. Current studies showed that the synthesized degradable polymer may further be subjected to in vivo studies and employed as a potential candidate for biomedical applications, i.e., controlled-drug delivery and tissue engineering. In addition, the experimental data were analyzed by graphical and statistical methods, and it was found that the weight loss of PMEEDEAP is linear function of time, i.e., %$ w_{t} = - 1 \times 10^{-3} \;t_{{\text{hr}}} + 1.068. %$ The value of the coefficient of determination (R2) is found to be 0.978, which indicates that the workability of the model is good. Polyphosphazenes (dpeaa)DE-He213 Synthesis (dpeaa)DE-He213 Properties (dpeaa)DE-He213 Hydrolytic degradation (dpeaa)DE-He213 Mathematical model (dpeaa)DE-He213 Intisar, Azeem verfasserin aut Hussain, Habib verfasserin aut Ali, Zulfiqar verfasserin aut Naz, Asma verfasserin aut Hussain, Shabbir verfasserin aut Shahzady, Tanzeela G. verfasserin aut Waqas, Muhammad verfasserin aut Enthalten in The Arabian journal for science and engineering Berlin : Springer, 2011 45(2019), 1 vom: 10. Dez., Seite 241-247 (DE-627)588780731 (DE-600)2471504-9 2191-4281 nnns volume:45 year:2019 number:1 day:10 month:12 pages:241-247 https://dx.doi.org/10.1007/s13369-019-04278-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 31.00 ASE AR 45 2019 1 10 12 241-247 |
| allfieldsGer |
10.1007/s13369-019-04278-8 doi (DE-627)SPR03207736X (SPR)s13369-019-04278-8-e DE-627 ger DE-627 rakwb eng 600 500 ASE 31.00 bkl Amin, Abid M. verfasserin aut Synthesis, Characterization, Hydrolytic Degradation and Mathematical Modeling of Poly[bis(2(2-methoxyethoxyethoxy diethylamino)phosphazene] 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The use of polymer-based polyphosphazene is increasing in biomedical industry due to their degradable nature, and their specific role can further be tailored by substituting the chloro groups in the linear precursor with suitable nucleophiles. In this study, we aimed to synthesize a novel degradable polymer based on polyphosphazene by derivatizing the linear poly(dichlorophosphazene) precursor with diethyl amine and 2-(2-methoxyethoxy)ethanol. The structure of the synthesized polymer, poly[bis(2(2-methoxyethoxyethoxy diethylamino)phosphazene] (PMEEDEAP) was elucidated with 1H NMR and 31P NMR. The molar mass distribution and molecular weight of the synthesized polymers were assessed by employing GPC. The hydrolytic degradation, in vitro, of the polymer was carried out in phosphate-buffered saline (PBS) with pH ~ 7.0 and at 37 °C. The polymer showed a weight loss of 95% in 5 weeks. Current studies showed that the synthesized degradable polymer may further be subjected to in vivo studies and employed as a potential candidate for biomedical applications, i.e., controlled-drug delivery and tissue engineering. In addition, the experimental data were analyzed by graphical and statistical methods, and it was found that the weight loss of PMEEDEAP is linear function of time, i.e., %$ w_{t} = - 1 \times 10^{-3} \;t_{{\text{hr}}} + 1.068. %$ The value of the coefficient of determination (R2) is found to be 0.978, which indicates that the workability of the model is good. Polyphosphazenes (dpeaa)DE-He213 Synthesis (dpeaa)DE-He213 Properties (dpeaa)DE-He213 Hydrolytic degradation (dpeaa)DE-He213 Mathematical model (dpeaa)DE-He213 Intisar, Azeem verfasserin aut Hussain, Habib verfasserin aut Ali, Zulfiqar verfasserin aut Naz, Asma verfasserin aut Hussain, Shabbir verfasserin aut Shahzady, Tanzeela G. verfasserin aut Waqas, Muhammad verfasserin aut Enthalten in The Arabian journal for science and engineering Berlin : Springer, 2011 45(2019), 1 vom: 10. Dez., Seite 241-247 (DE-627)588780731 (DE-600)2471504-9 2191-4281 nnns volume:45 year:2019 number:1 day:10 month:12 pages:241-247 https://dx.doi.org/10.1007/s13369-019-04278-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 31.00 ASE AR 45 2019 1 10 12 241-247 |
| allfieldsSound |
10.1007/s13369-019-04278-8 doi (DE-627)SPR03207736X (SPR)s13369-019-04278-8-e DE-627 ger DE-627 rakwb eng 600 500 ASE 31.00 bkl Amin, Abid M. verfasserin aut Synthesis, Characterization, Hydrolytic Degradation and Mathematical Modeling of Poly[bis(2(2-methoxyethoxyethoxy diethylamino)phosphazene] 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The use of polymer-based polyphosphazene is increasing in biomedical industry due to their degradable nature, and their specific role can further be tailored by substituting the chloro groups in the linear precursor with suitable nucleophiles. In this study, we aimed to synthesize a novel degradable polymer based on polyphosphazene by derivatizing the linear poly(dichlorophosphazene) precursor with diethyl amine and 2-(2-methoxyethoxy)ethanol. The structure of the synthesized polymer, poly[bis(2(2-methoxyethoxyethoxy diethylamino)phosphazene] (PMEEDEAP) was elucidated with 1H NMR and 31P NMR. The molar mass distribution and molecular weight of the synthesized polymers were assessed by employing GPC. The hydrolytic degradation, in vitro, of the polymer was carried out in phosphate-buffered saline (PBS) with pH ~ 7.0 and at 37 °C. The polymer showed a weight loss of 95% in 5 weeks. Current studies showed that the synthesized degradable polymer may further be subjected to in vivo studies and employed as a potential candidate for biomedical applications, i.e., controlled-drug delivery and tissue engineering. In addition, the experimental data were analyzed by graphical and statistical methods, and it was found that the weight loss of PMEEDEAP is linear function of time, i.e., %$ w_{t} = - 1 \times 10^{-3} \;t_{{\text{hr}}} + 1.068. %$ The value of the coefficient of determination (R2) is found to be 0.978, which indicates that the workability of the model is good. Polyphosphazenes (dpeaa)DE-He213 Synthesis (dpeaa)DE-He213 Properties (dpeaa)DE-He213 Hydrolytic degradation (dpeaa)DE-He213 Mathematical model (dpeaa)DE-He213 Intisar, Azeem verfasserin aut Hussain, Habib verfasserin aut Ali, Zulfiqar verfasserin aut Naz, Asma verfasserin aut Hussain, Shabbir verfasserin aut Shahzady, Tanzeela G. verfasserin aut Waqas, Muhammad verfasserin aut Enthalten in The Arabian journal for science and engineering Berlin : Springer, 2011 45(2019), 1 vom: 10. Dez., Seite 241-247 (DE-627)588780731 (DE-600)2471504-9 2191-4281 nnns volume:45 year:2019 number:1 day:10 month:12 pages:241-247 https://dx.doi.org/10.1007/s13369-019-04278-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 31.00 ASE AR 45 2019 1 10 12 241-247 |
| language |
English |
| source |
Enthalten in The Arabian journal for science and engineering 45(2019), 1 vom: 10. Dez., Seite 241-247 volume:45 year:2019 number:1 day:10 month:12 pages:241-247 |
| sourceStr |
Enthalten in The Arabian journal for science and engineering 45(2019), 1 vom: 10. Dez., Seite 241-247 volume:45 year:2019 number:1 day:10 month:12 pages:241-247 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| topic_facet |
Polyphosphazenes Synthesis Properties Hydrolytic degradation Mathematical model |
| dewey-raw |
600 |
| isfreeaccess_bool |
false |
| container_title |
The Arabian journal for science and engineering |
| authorswithroles_txt_mv |
Amin, Abid M. @@aut@@ Intisar, Azeem @@aut@@ Hussain, Habib @@aut@@ Ali, Zulfiqar @@aut@@ Naz, Asma @@aut@@ Hussain, Shabbir @@aut@@ Shahzady, Tanzeela G. @@aut@@ Waqas, Muhammad @@aut@@ |
| publishDateDaySort_date |
2019-12-10T00:00:00Z |
| hierarchy_top_id |
588780731 |
| dewey-sort |
3600 |
| id |
SPR03207736X |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR03207736X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519142235.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201007s2019 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s13369-019-04278-8</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR03207736X</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s13369-019-04278-8-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">600</subfield><subfield code="a">500</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">31.00</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Amin, Abid M.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Synthesis, Characterization, Hydrolytic Degradation and Mathematical Modeling of Poly[bis(2(2-methoxyethoxyethoxy diethylamino)phosphazene]</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract The use of polymer-based polyphosphazene is increasing in biomedical industry due to their degradable nature, and their specific role can further be tailored by substituting the chloro groups in the linear precursor with suitable nucleophiles. In this study, we aimed to synthesize a novel degradable polymer based on polyphosphazene by derivatizing the linear poly(dichlorophosphazene) precursor with diethyl amine and 2-(2-methoxyethoxy)ethanol. The structure of the synthesized polymer, poly[bis(2(2-methoxyethoxyethoxy diethylamino)phosphazene] (PMEEDEAP) was elucidated with 1H NMR and 31P NMR. The molar mass distribution and molecular weight of the synthesized polymers were assessed by employing GPC. The hydrolytic degradation, in vitro, of the polymer was carried out in phosphate-buffered saline (PBS) with pH ~ 7.0 and at 37 °C. The polymer showed a weight loss of 95% in 5 weeks. Current studies showed that the synthesized degradable polymer may further be subjected to in vivo studies and employed as a potential candidate for biomedical applications, i.e., controlled-drug delivery and tissue engineering. In addition, the experimental data were analyzed by graphical and statistical methods, and it was found that the weight loss of PMEEDEAP is linear function of time, i.e., %$ w_{t} = - 1 \times 10^{-3} \;t_{{\text{hr}}} + 1.068. %$ The value of the coefficient of determination (R2) is found to be 0.978, which indicates that the workability of the model is good.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Polyphosphazenes</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Synthesis</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Properties</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Hydrolytic degradation</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mathematical model</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Intisar, Azeem</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hussain, Habib</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ali, Zulfiqar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Naz, Asma</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hussain, Shabbir</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Shahzady, Tanzeela G.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Waqas, Muhammad</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">The Arabian journal for science and engineering</subfield><subfield code="d">Berlin : Springer, 2011</subfield><subfield code="g">45(2019), 1 vom: 10. Dez., Seite 241-247</subfield><subfield code="w">(DE-627)588780731</subfield><subfield code="w">(DE-600)2471504-9</subfield><subfield code="x">2191-4281</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:45</subfield><subfield code="g">year:2019</subfield><subfield code="g">number:1</subfield><subfield code="g">day:10</subfield><subfield code="g">month:12</subfield><subfield code="g">pages:241-247</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1007/s13369-019-04278-8</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_11</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_32</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_90</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_100</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_120</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_138</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_150</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_152</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_171</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_187</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_224</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_250</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_281</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_370</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_636</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_702</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2001</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2003</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2004</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2006</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2007</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2008</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2010</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2011</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2015</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2020</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2021</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2025</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2026</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2027</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2031</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2034</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2038</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2039</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2044</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2048</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2049</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2050</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2057</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2059</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2061</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2064</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2065</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2068</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2070</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2086</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2088</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2093</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2106</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2107</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2108</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2111</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2113</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2116</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2118</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2119</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2122</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2129</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2143</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2144</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2147</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2148</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2152</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2153</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2188</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2232</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2336</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2446</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2470</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2472</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2507</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2522</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2548</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4035</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4046</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4242</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4246</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4251</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4326</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4333</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4334</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4335</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4336</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4393</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">31.00</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">45</subfield><subfield code="j">2019</subfield><subfield code="e">1</subfield><subfield code="b">10</subfield><subfield code="c">12</subfield><subfield code="h">241-247</subfield></datafield></record></collection>
|
| author |
Amin, Abid M. |
| spellingShingle |
Amin, Abid M. ddc 600 bkl 31.00 misc Polyphosphazenes misc Synthesis misc Properties misc Hydrolytic degradation misc Mathematical model Synthesis, Characterization, Hydrolytic Degradation and Mathematical Modeling of Poly[bis(2(2-methoxyethoxyethoxy diethylamino)phosphazene] |
| authorStr |
Amin, Abid M. |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)588780731 |
| format |
electronic Article |
| dewey-ones |
600 - Technology 500 - Natural sciences & mathematics |
| delete_txt_mv |
keep |
| author_role |
aut aut aut aut aut aut aut aut |
| collection |
springer |
| remote_str |
true |
| illustrated |
Not Illustrated |
| issn |
2191-4281 |
| topic_title |
600 500 ASE 31.00 bkl Synthesis, Characterization, Hydrolytic Degradation and Mathematical Modeling of Poly[bis(2(2-methoxyethoxyethoxy diethylamino)phosphazene] Polyphosphazenes (dpeaa)DE-He213 Synthesis (dpeaa)DE-He213 Properties (dpeaa)DE-He213 Hydrolytic degradation (dpeaa)DE-He213 Mathematical model (dpeaa)DE-He213 |
| topic |
ddc 600 bkl 31.00 misc Polyphosphazenes misc Synthesis misc Properties misc Hydrolytic degradation misc Mathematical model |
| topic_unstemmed |
ddc 600 bkl 31.00 misc Polyphosphazenes misc Synthesis misc Properties misc Hydrolytic degradation misc Mathematical model |
| topic_browse |
ddc 600 bkl 31.00 misc Polyphosphazenes misc Synthesis misc Properties misc Hydrolytic degradation misc Mathematical model |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
cr |
| hierarchy_parent_title |
The Arabian journal for science and engineering |
| hierarchy_parent_id |
588780731 |
| dewey-tens |
600 - Technology 500 - Science |
| hierarchy_top_title |
The Arabian journal for science and engineering |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)588780731 (DE-600)2471504-9 |
| title |
Synthesis, Characterization, Hydrolytic Degradation and Mathematical Modeling of Poly[bis(2(2-methoxyethoxyethoxy diethylamino)phosphazene] |
| ctrlnum |
(DE-627)SPR03207736X (SPR)s13369-019-04278-8-e |
| title_full |
Synthesis, Characterization, Hydrolytic Degradation and Mathematical Modeling of Poly[bis(2(2-methoxyethoxyethoxy diethylamino)phosphazene] |
| author_sort |
Amin, Abid M. |
| journal |
The Arabian journal for science and engineering |
| journalStr |
The Arabian journal for science and engineering |
| lang_code |
eng |
| isOA_bool |
false |
| dewey-hundreds |
600 - Technology 500 - Science |
| recordtype |
marc |
| publishDateSort |
2019 |
| contenttype_str_mv |
txt |
| container_start_page |
241 |
| author_browse |
Amin, Abid M. Intisar, Azeem Hussain, Habib Ali, Zulfiqar Naz, Asma Hussain, Shabbir Shahzady, Tanzeela G. Waqas, Muhammad |
| container_volume |
45 |
| class |
600 500 ASE 31.00 bkl |
| format_se |
Elektronische Aufsätze |
| author-letter |
Amin, Abid M. |
| doi_str_mv |
10.1007/s13369-019-04278-8 |
| dewey-full |
600 500 |
| author2-role |
verfasserin |
| title_sort |
synthesis, characterization, hydrolytic degradation and mathematical modeling of poly[bis(2(2-methoxyethoxyethoxy diethylamino)phosphazene] |
| title_auth |
Synthesis, Characterization, Hydrolytic Degradation and Mathematical Modeling of Poly[bis(2(2-methoxyethoxyethoxy diethylamino)phosphazene] |
| abstract |
Abstract The use of polymer-based polyphosphazene is increasing in biomedical industry due to their degradable nature, and their specific role can further be tailored by substituting the chloro groups in the linear precursor with suitable nucleophiles. In this study, we aimed to synthesize a novel degradable polymer based on polyphosphazene by derivatizing the linear poly(dichlorophosphazene) precursor with diethyl amine and 2-(2-methoxyethoxy)ethanol. The structure of the synthesized polymer, poly[bis(2(2-methoxyethoxyethoxy diethylamino)phosphazene] (PMEEDEAP) was elucidated with 1H NMR and 31P NMR. The molar mass distribution and molecular weight of the synthesized polymers were assessed by employing GPC. The hydrolytic degradation, in vitro, of the polymer was carried out in phosphate-buffered saline (PBS) with pH ~ 7.0 and at 37 °C. The polymer showed a weight loss of 95% in 5 weeks. Current studies showed that the synthesized degradable polymer may further be subjected to in vivo studies and employed as a potential candidate for biomedical applications, i.e., controlled-drug delivery and tissue engineering. In addition, the experimental data were analyzed by graphical and statistical methods, and it was found that the weight loss of PMEEDEAP is linear function of time, i.e., %$ w_{t} = - 1 \times 10^{-3} \;t_{{\text{hr}}} + 1.068. %$ The value of the coefficient of determination (R2) is found to be 0.978, which indicates that the workability of the model is good. |
| abstractGer |
Abstract The use of polymer-based polyphosphazene is increasing in biomedical industry due to their degradable nature, and their specific role can further be tailored by substituting the chloro groups in the linear precursor with suitable nucleophiles. In this study, we aimed to synthesize a novel degradable polymer based on polyphosphazene by derivatizing the linear poly(dichlorophosphazene) precursor with diethyl amine and 2-(2-methoxyethoxy)ethanol. The structure of the synthesized polymer, poly[bis(2(2-methoxyethoxyethoxy diethylamino)phosphazene] (PMEEDEAP) was elucidated with 1H NMR and 31P NMR. The molar mass distribution and molecular weight of the synthesized polymers were assessed by employing GPC. The hydrolytic degradation, in vitro, of the polymer was carried out in phosphate-buffered saline (PBS) with pH ~ 7.0 and at 37 °C. The polymer showed a weight loss of 95% in 5 weeks. Current studies showed that the synthesized degradable polymer may further be subjected to in vivo studies and employed as a potential candidate for biomedical applications, i.e., controlled-drug delivery and tissue engineering. In addition, the experimental data were analyzed by graphical and statistical methods, and it was found that the weight loss of PMEEDEAP is linear function of time, i.e., %$ w_{t} = - 1 \times 10^{-3} \;t_{{\text{hr}}} + 1.068. %$ The value of the coefficient of determination (R2) is found to be 0.978, which indicates that the workability of the model is good. |
| abstract_unstemmed |
Abstract The use of polymer-based polyphosphazene is increasing in biomedical industry due to their degradable nature, and their specific role can further be tailored by substituting the chloro groups in the linear precursor with suitable nucleophiles. In this study, we aimed to synthesize a novel degradable polymer based on polyphosphazene by derivatizing the linear poly(dichlorophosphazene) precursor with diethyl amine and 2-(2-methoxyethoxy)ethanol. The structure of the synthesized polymer, poly[bis(2(2-methoxyethoxyethoxy diethylamino)phosphazene] (PMEEDEAP) was elucidated with 1H NMR and 31P NMR. The molar mass distribution and molecular weight of the synthesized polymers were assessed by employing GPC. The hydrolytic degradation, in vitro, of the polymer was carried out in phosphate-buffered saline (PBS) with pH ~ 7.0 and at 37 °C. The polymer showed a weight loss of 95% in 5 weeks. Current studies showed that the synthesized degradable polymer may further be subjected to in vivo studies and employed as a potential candidate for biomedical applications, i.e., controlled-drug delivery and tissue engineering. In addition, the experimental data were analyzed by graphical and statistical methods, and it was found that the weight loss of PMEEDEAP is linear function of time, i.e., %$ w_{t} = - 1 \times 10^{-3} \;t_{{\text{hr}}} + 1.068. %$ The value of the coefficient of determination (R2) is found to be 0.978, which indicates that the workability of the model is good. |
| collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 |
| container_issue |
1 |
| title_short |
Synthesis, Characterization, Hydrolytic Degradation and Mathematical Modeling of Poly[bis(2(2-methoxyethoxyethoxy diethylamino)phosphazene] |
| url |
https://dx.doi.org/10.1007/s13369-019-04278-8 |
| remote_bool |
true |
| author2 |
Intisar, Azeem Hussain, Habib Ali, Zulfiqar Naz, Asma Hussain, Shabbir Shahzady, Tanzeela G. Waqas, Muhammad |
| author2Str |
Intisar, Azeem Hussain, Habib Ali, Zulfiqar Naz, Asma Hussain, Shabbir Shahzady, Tanzeela G. Waqas, Muhammad |
| ppnlink |
588780731 |
| mediatype_str_mv |
c |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| doi_str |
10.1007/s13369-019-04278-8 |
| up_date |
2024-07-04T02:21:55.979Z |
| _version_ |
1803613336745541632 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR03207736X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519142235.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201007s2019 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s13369-019-04278-8</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR03207736X</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s13369-019-04278-8-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">600</subfield><subfield code="a">500</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">31.00</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Amin, Abid M.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Synthesis, Characterization, Hydrolytic Degradation and Mathematical Modeling of Poly[bis(2(2-methoxyethoxyethoxy diethylamino)phosphazene]</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract The use of polymer-based polyphosphazene is increasing in biomedical industry due to their degradable nature, and their specific role can further be tailored by substituting the chloro groups in the linear precursor with suitable nucleophiles. In this study, we aimed to synthesize a novel degradable polymer based on polyphosphazene by derivatizing the linear poly(dichlorophosphazene) precursor with diethyl amine and 2-(2-methoxyethoxy)ethanol. The structure of the synthesized polymer, poly[bis(2(2-methoxyethoxyethoxy diethylamino)phosphazene] (PMEEDEAP) was elucidated with 1H NMR and 31P NMR. The molar mass distribution and molecular weight of the synthesized polymers were assessed by employing GPC. The hydrolytic degradation, in vitro, of the polymer was carried out in phosphate-buffered saline (PBS) with pH ~ 7.0 and at 37 °C. The polymer showed a weight loss of 95% in 5 weeks. Current studies showed that the synthesized degradable polymer may further be subjected to in vivo studies and employed as a potential candidate for biomedical applications, i.e., controlled-drug delivery and tissue engineering. In addition, the experimental data were analyzed by graphical and statistical methods, and it was found that the weight loss of PMEEDEAP is linear function of time, i.e., %$ w_{t} = - 1 \times 10^{-3} \;t_{{\text{hr}}} + 1.068. %$ The value of the coefficient of determination (R2) is found to be 0.978, which indicates that the workability of the model is good.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Polyphosphazenes</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Synthesis</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Properties</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Hydrolytic degradation</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mathematical model</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Intisar, Azeem</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hussain, Habib</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ali, Zulfiqar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Naz, Asma</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hussain, Shabbir</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Shahzady, Tanzeela G.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Waqas, Muhammad</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">The Arabian journal for science and engineering</subfield><subfield code="d">Berlin : Springer, 2011</subfield><subfield code="g">45(2019), 1 vom: 10. Dez., Seite 241-247</subfield><subfield code="w">(DE-627)588780731</subfield><subfield code="w">(DE-600)2471504-9</subfield><subfield code="x">2191-4281</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:45</subfield><subfield code="g">year:2019</subfield><subfield code="g">number:1</subfield><subfield code="g">day:10</subfield><subfield code="g">month:12</subfield><subfield code="g">pages:241-247</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1007/s13369-019-04278-8</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_11</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_32</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_90</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_100</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_120</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_138</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_150</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_152</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_171</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_187</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_224</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_250</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_281</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_370</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_636</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_702</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2001</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2003</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2004</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2006</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2007</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2008</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2010</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2011</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2015</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2020</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2021</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2025</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2026</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2027</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2031</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2034</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2038</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2039</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2044</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2048</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2049</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2050</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2057</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2059</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2061</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2064</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2065</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2068</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2070</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2086</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2088</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2093</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2106</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2107</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2108</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2111</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2113</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2116</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2118</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2119</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2122</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2129</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2143</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2144</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2147</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2148</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2152</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2153</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2188</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2232</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2336</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2446</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2470</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2472</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2507</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2522</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2548</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4035</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4046</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4242</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4246</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4251</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4326</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4333</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4334</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4335</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4336</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4393</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">31.00</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">45</subfield><subfield code="j">2019</subfield><subfield code="e">1</subfield><subfield code="b">10</subfield><subfield code="c">12</subfield><subfield code="h">241-247</subfield></datafield></record></collection>
|
| score |
7.400832 |