Cingulum bundle white matter in MAG-knockout mice

Abstract Myelin associated glycoprotein (MAG) is an oligodendrocyte-derived gene whose expression is decreased in schizophrenia. Several measures of white matter integrity appear abnormal in schizophrenia, specifically in the anterior cingulate gyrus. We studied mice lacking MAG as a potential model...
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Autor*in:	Segal, Devorah [verfasserIn] Carpenter, David [verfasserIn] Höistad, Malin [verfasserIn] Haroutunian, Vahram [verfasserIn] Tang, Cheuk Y. [verfasserIn] Hof, Patrick R. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2010

Schlagwörter:	MAG Cingulum bundle Stereology DTI Schizophrenia Mouse model

Übergeordnetes Werk:	Enthalten in: Translational Neuroscience - Berlin : Springer, 2010, 1(2010), 2 vom: Juni, Seite 131-138
Übergeordnetes Werk:	volume:1 ; year:2010 ; number:2 ; month:06 ; pages:131-138

Links:	Volltext

DOI / URN:	10.2478/v10134-010-0019-6

Katalog-ID:	SPR032090358

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520			\|a Abstract Myelin associated glycoprotein (MAG) is an oligodendrocyte-derived gene whose expression is decreased in schizophrenia. Several measures of white matter integrity appear abnormal in schizophrenia, specifically in the anterior cingulate gyrus. We studied mice lacking MAG as a potential model of dysmyelination. Using the stereological “Space Balls” method, we estimated myelinated fiber length density in the cingulum bundle in adult knockout and control mice. We performed diffusion anisotropy imaging in these animals, measuring fractional anisotropy (FA) in a region of the cingulum bundle. We found no differences in cingulum myelinated fiber length density between the two groups, although we did note an age-related decrease regardless of genotype. No differences were noted in FA either, but an age-related decrease was seen as well. These findings imply that MAG dysfunction alone is not sufficient to cause the white matter alterations seen in schizophrenia.
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allfields	10.2478/v10134-010-0019-6 doi (DE-627)SPR032090358 (SPR)v10134-010-0019-6-e DE-627 ger DE-627 rakwb eng 610 570 ASE Segal, Devorah verfasserin aut Cingulum bundle white matter in MAG-knockout mice 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Myelin associated glycoprotein (MAG) is an oligodendrocyte-derived gene whose expression is decreased in schizophrenia. Several measures of white matter integrity appear abnormal in schizophrenia, specifically in the anterior cingulate gyrus. We studied mice lacking MAG as a potential model of dysmyelination. Using the stereological “Space Balls” method, we estimated myelinated fiber length density in the cingulum bundle in adult knockout and control mice. We performed diffusion anisotropy imaging in these animals, measuring fractional anisotropy (FA) in a region of the cingulum bundle. We found no differences in cingulum myelinated fiber length density between the two groups, although we did note an age-related decrease regardless of genotype. No differences were noted in FA either, but an age-related decrease was seen as well. These findings imply that MAG dysfunction alone is not sufficient to cause the white matter alterations seen in schizophrenia. MAG (dpeaa)DE-He213 Cingulum bundle (dpeaa)DE-He213 Stereology (dpeaa)DE-He213 DTI (dpeaa)DE-He213 Schizophrenia (dpeaa)DE-He213 Mouse model (dpeaa)DE-He213 Carpenter, David verfasserin aut Höistad, Malin verfasserin aut Haroutunian, Vahram verfasserin aut Tang, Cheuk Y. verfasserin aut Hof, Patrick R. verfasserin aut Enthalten in Translational Neuroscience Berlin : Springer, 2010 1(2010), 2 vom: Juni, Seite 131-138 (DE-627)640087507 (DE-600)2581219-1 2081-6936 nnns volume:1 year:2010 number:2 month:06 pages:131-138 https://dx.doi.org/10.2478/v10134-010-0019-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2014 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2010 2 06 131-138
spelling	10.2478/v10134-010-0019-6 doi (DE-627)SPR032090358 (SPR)v10134-010-0019-6-e DE-627 ger DE-627 rakwb eng 610 570 ASE Segal, Devorah verfasserin aut Cingulum bundle white matter in MAG-knockout mice 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Myelin associated glycoprotein (MAG) is an oligodendrocyte-derived gene whose expression is decreased in schizophrenia. Several measures of white matter integrity appear abnormal in schizophrenia, specifically in the anterior cingulate gyrus. We studied mice lacking MAG as a potential model of dysmyelination. Using the stereological “Space Balls” method, we estimated myelinated fiber length density in the cingulum bundle in adult knockout and control mice. We performed diffusion anisotropy imaging in these animals, measuring fractional anisotropy (FA) in a region of the cingulum bundle. We found no differences in cingulum myelinated fiber length density between the two groups, although we did note an age-related decrease regardless of genotype. No differences were noted in FA either, but an age-related decrease was seen as well. These findings imply that MAG dysfunction alone is not sufficient to cause the white matter alterations seen in schizophrenia. MAG (dpeaa)DE-He213 Cingulum bundle (dpeaa)DE-He213 Stereology (dpeaa)DE-He213 DTI (dpeaa)DE-He213 Schizophrenia (dpeaa)DE-He213 Mouse model (dpeaa)DE-He213 Carpenter, David verfasserin aut Höistad, Malin verfasserin aut Haroutunian, Vahram verfasserin aut Tang, Cheuk Y. verfasserin aut Hof, Patrick R. verfasserin aut Enthalten in Translational Neuroscience Berlin : Springer, 2010 1(2010), 2 vom: Juni, Seite 131-138 (DE-627)640087507 (DE-600)2581219-1 2081-6936 nnns volume:1 year:2010 number:2 month:06 pages:131-138 https://dx.doi.org/10.2478/v10134-010-0019-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2014 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2010 2 06 131-138
allfields_unstemmed	10.2478/v10134-010-0019-6 doi (DE-627)SPR032090358 (SPR)v10134-010-0019-6-e DE-627 ger DE-627 rakwb eng 610 570 ASE Segal, Devorah verfasserin aut Cingulum bundle white matter in MAG-knockout mice 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Myelin associated glycoprotein (MAG) is an oligodendrocyte-derived gene whose expression is decreased in schizophrenia. Several measures of white matter integrity appear abnormal in schizophrenia, specifically in the anterior cingulate gyrus. We studied mice lacking MAG as a potential model of dysmyelination. Using the stereological “Space Balls” method, we estimated myelinated fiber length density in the cingulum bundle in adult knockout and control mice. We performed diffusion anisotropy imaging in these animals, measuring fractional anisotropy (FA) in a region of the cingulum bundle. We found no differences in cingulum myelinated fiber length density between the two groups, although we did note an age-related decrease regardless of genotype. No differences were noted in FA either, but an age-related decrease was seen as well. These findings imply that MAG dysfunction alone is not sufficient to cause the white matter alterations seen in schizophrenia. MAG (dpeaa)DE-He213 Cingulum bundle (dpeaa)DE-He213 Stereology (dpeaa)DE-He213 DTI (dpeaa)DE-He213 Schizophrenia (dpeaa)DE-He213 Mouse model (dpeaa)DE-He213 Carpenter, David verfasserin aut Höistad, Malin verfasserin aut Haroutunian, Vahram verfasserin aut Tang, Cheuk Y. verfasserin aut Hof, Patrick R. verfasserin aut Enthalten in Translational Neuroscience Berlin : Springer, 2010 1(2010), 2 vom: Juni, Seite 131-138 (DE-627)640087507 (DE-600)2581219-1 2081-6936 nnns volume:1 year:2010 number:2 month:06 pages:131-138 https://dx.doi.org/10.2478/v10134-010-0019-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2014 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2010 2 06 131-138
allfieldsGer	10.2478/v10134-010-0019-6 doi (DE-627)SPR032090358 (SPR)v10134-010-0019-6-e DE-627 ger DE-627 rakwb eng 610 570 ASE Segal, Devorah verfasserin aut Cingulum bundle white matter in MAG-knockout mice 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Myelin associated glycoprotein (MAG) is an oligodendrocyte-derived gene whose expression is decreased in schizophrenia. Several measures of white matter integrity appear abnormal in schizophrenia, specifically in the anterior cingulate gyrus. We studied mice lacking MAG as a potential model of dysmyelination. Using the stereological “Space Balls” method, we estimated myelinated fiber length density in the cingulum bundle in adult knockout and control mice. We performed diffusion anisotropy imaging in these animals, measuring fractional anisotropy (FA) in a region of the cingulum bundle. We found no differences in cingulum myelinated fiber length density between the two groups, although we did note an age-related decrease regardless of genotype. No differences were noted in FA either, but an age-related decrease was seen as well. These findings imply that MAG dysfunction alone is not sufficient to cause the white matter alterations seen in schizophrenia. MAG (dpeaa)DE-He213 Cingulum bundle (dpeaa)DE-He213 Stereology (dpeaa)DE-He213 DTI (dpeaa)DE-He213 Schizophrenia (dpeaa)DE-He213 Mouse model (dpeaa)DE-He213 Carpenter, David verfasserin aut Höistad, Malin verfasserin aut Haroutunian, Vahram verfasserin aut Tang, Cheuk Y. verfasserin aut Hof, Patrick R. verfasserin aut Enthalten in Translational Neuroscience Berlin : Springer, 2010 1(2010), 2 vom: Juni, Seite 131-138 (DE-627)640087507 (DE-600)2581219-1 2081-6936 nnns volume:1 year:2010 number:2 month:06 pages:131-138 https://dx.doi.org/10.2478/v10134-010-0019-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2014 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2010 2 06 131-138
allfieldsSound	10.2478/v10134-010-0019-6 doi (DE-627)SPR032090358 (SPR)v10134-010-0019-6-e DE-627 ger DE-627 rakwb eng 610 570 ASE Segal, Devorah verfasserin aut Cingulum bundle white matter in MAG-knockout mice 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Myelin associated glycoprotein (MAG) is an oligodendrocyte-derived gene whose expression is decreased in schizophrenia. Several measures of white matter integrity appear abnormal in schizophrenia, specifically in the anterior cingulate gyrus. We studied mice lacking MAG as a potential model of dysmyelination. Using the stereological “Space Balls” method, we estimated myelinated fiber length density in the cingulum bundle in adult knockout and control mice. We performed diffusion anisotropy imaging in these animals, measuring fractional anisotropy (FA) in a region of the cingulum bundle. We found no differences in cingulum myelinated fiber length density between the two groups, although we did note an age-related decrease regardless of genotype. No differences were noted in FA either, but an age-related decrease was seen as well. These findings imply that MAG dysfunction alone is not sufficient to cause the white matter alterations seen in schizophrenia. MAG (dpeaa)DE-He213 Cingulum bundle (dpeaa)DE-He213 Stereology (dpeaa)DE-He213 DTI (dpeaa)DE-He213 Schizophrenia (dpeaa)DE-He213 Mouse model (dpeaa)DE-He213 Carpenter, David verfasserin aut Höistad, Malin verfasserin aut Haroutunian, Vahram verfasserin aut Tang, Cheuk Y. verfasserin aut Hof, Patrick R. verfasserin aut Enthalten in Translational Neuroscience Berlin : Springer, 2010 1(2010), 2 vom: Juni, Seite 131-138 (DE-627)640087507 (DE-600)2581219-1 2081-6936 nnns volume:1 year:2010 number:2 month:06 pages:131-138 https://dx.doi.org/10.2478/v10134-010-0019-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2014 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2010 2 06 131-138
language	English
source	Enthalten in Translational Neuroscience 1(2010), 2 vom: Juni, Seite 131-138 volume:1 year:2010 number:2 month:06 pages:131-138
sourceStr	Enthalten in Translational Neuroscience 1(2010), 2 vom: Juni, Seite 131-138 volume:1 year:2010 number:2 month:06 pages:131-138
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institution	findex.gbv.de
topic_facet	MAG Cingulum bundle Stereology DTI Schizophrenia Mouse model
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container_title	Translational Neuroscience
authorswithroles_txt_mv	Segal, Devorah @@aut@@ Carpenter, David @@aut@@ Höistad, Malin @@aut@@ Haroutunian, Vahram @@aut@@ Tang, Cheuk Y. @@aut@@ Hof, Patrick R. @@aut@@
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title	Cingulum bundle white matter in MAG-knockout mice
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title_full	Cingulum bundle white matter in MAG-knockout mice
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title_sort	cingulum bundle white matter in mag-knockout mice
title_auth	Cingulum bundle white matter in MAG-knockout mice
abstract	Abstract Myelin associated glycoprotein (MAG) is an oligodendrocyte-derived gene whose expression is decreased in schizophrenia. Several measures of white matter integrity appear abnormal in schizophrenia, specifically in the anterior cingulate gyrus. We studied mice lacking MAG as a potential model of dysmyelination. Using the stereological “Space Balls” method, we estimated myelinated fiber length density in the cingulum bundle in adult knockout and control mice. We performed diffusion anisotropy imaging in these animals, measuring fractional anisotropy (FA) in a region of the cingulum bundle. We found no differences in cingulum myelinated fiber length density between the two groups, although we did note an age-related decrease regardless of genotype. No differences were noted in FA either, but an age-related decrease was seen as well. These findings imply that MAG dysfunction alone is not sufficient to cause the white matter alterations seen in schizophrenia.
abstractGer	Abstract Myelin associated glycoprotein (MAG) is an oligodendrocyte-derived gene whose expression is decreased in schizophrenia. Several measures of white matter integrity appear abnormal in schizophrenia, specifically in the anterior cingulate gyrus. We studied mice lacking MAG as a potential model of dysmyelination. Using the stereological “Space Balls” method, we estimated myelinated fiber length density in the cingulum bundle in adult knockout and control mice. We performed diffusion anisotropy imaging in these animals, measuring fractional anisotropy (FA) in a region of the cingulum bundle. We found no differences in cingulum myelinated fiber length density between the two groups, although we did note an age-related decrease regardless of genotype. No differences were noted in FA either, but an age-related decrease was seen as well. These findings imply that MAG dysfunction alone is not sufficient to cause the white matter alterations seen in schizophrenia.
abstract_unstemmed	Abstract Myelin associated glycoprotein (MAG) is an oligodendrocyte-derived gene whose expression is decreased in schizophrenia. Several measures of white matter integrity appear abnormal in schizophrenia, specifically in the anterior cingulate gyrus. We studied mice lacking MAG as a potential model of dysmyelination. Using the stereological “Space Balls” method, we estimated myelinated fiber length density in the cingulum bundle in adult knockout and control mice. We performed diffusion anisotropy imaging in these animals, measuring fractional anisotropy (FA) in a region of the cingulum bundle. We found no differences in cingulum myelinated fiber length density between the two groups, although we did note an age-related decrease regardless of genotype. No differences were noted in FA either, but an age-related decrease was seen as well. These findings imply that MAG dysfunction alone is not sufficient to cause the white matter alterations seen in schizophrenia.
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title_short	Cingulum bundle white matter in MAG-knockout mice
url	https://dx.doi.org/10.2478/v10134-010-0019-6
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author2	Carpenter, David Höistad, Malin Haroutunian, Vahram Tang, Cheuk Y. Hof, Patrick R.
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up_date	2024-07-04T02:24:22.919Z
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