Metastatic neuroendocrine carcinoma of the colon: response to standard colorectal therapy

Abstract Colorectal neuroendocrine carcinoma (NEC) is a rare disease. There are no prospective randomized studies evaluating the best approach for these patients. Colorectal NEC is frequently treated in a similar way to small-cell cancers, because of its histologic appearance. We report a case of me...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Acevedo, Francisco [verfasserIn] Otarola, Claudia [verfasserIn] Valbuena, Jose [verfasserIn] Garrido, Marcelo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Schlagwörter:	Colorectal Neuroendocrine Neoplastic Therapy

Übergeordnetes Werk:	Enthalten in: International Cancer Conference journal - Tokyo : Springer Japan, 2012, 2(2012), 1 vom: 15. Nov., Seite 56-61
Übergeordnetes Werk:	volume:2 ; year:2012 ; number:1 ; day:15 ; month:11 ; pages:56-61

Links:	Volltext

DOI / URN:	10.1007/s13691-012-0065-7

Katalog-ID:	SPR032176635

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allfields	10.1007/s13691-012-0065-7 doi (DE-627)SPR032176635 (SPR)s13691-012-0065-7-e DE-627 ger DE-627 rakwb eng 610 ASE Acevedo, Francisco verfasserin aut Metastatic neuroendocrine carcinoma of the colon: response to standard colorectal therapy 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Colorectal neuroendocrine carcinoma (NEC) is a rare disease. There are no prospective randomized studies evaluating the best approach for these patients. Colorectal NEC is frequently treated in a similar way to small-cell cancers, because of its histologic appearance. We report a case of metastatic colorectal NEC which was treated with standard chemotherapy for metastatic colonic adenocarcinoma, including biological agents. A 47-year-old woman, with an unremarkable past medical history, presented to the emergency room complaining of a five-day history of abdominal distension, diffuse crampy pain, and vomiting. An abdominal computed tomography scan showed an obstructive tumor in the descending colon associated with multiple focal hepatic lesions. On the same day, she underwent an emergency laparotomy. A histologic examination revealed a tumor composed of malignant small and medium-sized cells with scant cytoplasm and immunoreactivity to chromogranin and synaptophysin consistent with a diagnosis of NEC. Six out of 20 excised lymph nodes were compromised, and a biopsy of the hepatic lesion showed similar features to the primary tumor. She later received palliative chemotherapy with 5-fluorouracil/leucovorin plus oxaliplatin (FOLFOX) and bevacizumab every other week, completing six cycles. At the end of the treatment she showed clinical improvement and partial response by imaging studies without significant toxicities. We emphasize the report on the treatment received by this patient and the need for further investigation on this matter. Colorectal (dpeaa)DE-He213 Neuroendocrine (dpeaa)DE-He213 Neoplastic (dpeaa)DE-He213 Therapy (dpeaa)DE-He213 Otarola, Claudia verfasserin aut Valbuena, Jose verfasserin aut Garrido, Marcelo verfasserin aut Enthalten in International Cancer Conference journal Tokyo : Springer Japan, 2012 2(2012), 1 vom: 15. Nov., Seite 56-61 (DE-627)71861111X (DE-600)2660498-X 2192-3183 nnns volume:2 year:2012 number:1 day:15 month:11 pages:56-61 https://dx.doi.org/10.1007/s13691-012-0065-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 2 2012 1 15 11 56-61
spelling	10.1007/s13691-012-0065-7 doi (DE-627)SPR032176635 (SPR)s13691-012-0065-7-e DE-627 ger DE-627 rakwb eng 610 ASE Acevedo, Francisco verfasserin aut Metastatic neuroendocrine carcinoma of the colon: response to standard colorectal therapy 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Colorectal neuroendocrine carcinoma (NEC) is a rare disease. There are no prospective randomized studies evaluating the best approach for these patients. Colorectal NEC is frequently treated in a similar way to small-cell cancers, because of its histologic appearance. We report a case of metastatic colorectal NEC which was treated with standard chemotherapy for metastatic colonic adenocarcinoma, including biological agents. A 47-year-old woman, with an unremarkable past medical history, presented to the emergency room complaining of a five-day history of abdominal distension, diffuse crampy pain, and vomiting. An abdominal computed tomography scan showed an obstructive tumor in the descending colon associated with multiple focal hepatic lesions. On the same day, she underwent an emergency laparotomy. A histologic examination revealed a tumor composed of malignant small and medium-sized cells with scant cytoplasm and immunoreactivity to chromogranin and synaptophysin consistent with a diagnosis of NEC. Six out of 20 excised lymph nodes were compromised, and a biopsy of the hepatic lesion showed similar features to the primary tumor. She later received palliative chemotherapy with 5-fluorouracil/leucovorin plus oxaliplatin (FOLFOX) and bevacizumab every other week, completing six cycles. At the end of the treatment she showed clinical improvement and partial response by imaging studies without significant toxicities. We emphasize the report on the treatment received by this patient and the need for further investigation on this matter. Colorectal (dpeaa)DE-He213 Neuroendocrine (dpeaa)DE-He213 Neoplastic (dpeaa)DE-He213 Therapy (dpeaa)DE-He213 Otarola, Claudia verfasserin aut Valbuena, Jose verfasserin aut Garrido, Marcelo verfasserin aut Enthalten in International Cancer Conference journal Tokyo : Springer Japan, 2012 2(2012), 1 vom: 15. Nov., Seite 56-61 (DE-627)71861111X (DE-600)2660498-X 2192-3183 nnns volume:2 year:2012 number:1 day:15 month:11 pages:56-61 https://dx.doi.org/10.1007/s13691-012-0065-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 2 2012 1 15 11 56-61
allfields_unstemmed	10.1007/s13691-012-0065-7 doi (DE-627)SPR032176635 (SPR)s13691-012-0065-7-e DE-627 ger DE-627 rakwb eng 610 ASE Acevedo, Francisco verfasserin aut Metastatic neuroendocrine carcinoma of the colon: response to standard colorectal therapy 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Colorectal neuroendocrine carcinoma (NEC) is a rare disease. There are no prospective randomized studies evaluating the best approach for these patients. Colorectal NEC is frequently treated in a similar way to small-cell cancers, because of its histologic appearance. We report a case of metastatic colorectal NEC which was treated with standard chemotherapy for metastatic colonic adenocarcinoma, including biological agents. A 47-year-old woman, with an unremarkable past medical history, presented to the emergency room complaining of a five-day history of abdominal distension, diffuse crampy pain, and vomiting. An abdominal computed tomography scan showed an obstructive tumor in the descending colon associated with multiple focal hepatic lesions. On the same day, she underwent an emergency laparotomy. A histologic examination revealed a tumor composed of malignant small and medium-sized cells with scant cytoplasm and immunoreactivity to chromogranin and synaptophysin consistent with a diagnosis of NEC. Six out of 20 excised lymph nodes were compromised, and a biopsy of the hepatic lesion showed similar features to the primary tumor. She later received palliative chemotherapy with 5-fluorouracil/leucovorin plus oxaliplatin (FOLFOX) and bevacizumab every other week, completing six cycles. At the end of the treatment she showed clinical improvement and partial response by imaging studies without significant toxicities. We emphasize the report on the treatment received by this patient and the need for further investigation on this matter. Colorectal (dpeaa)DE-He213 Neuroendocrine (dpeaa)DE-He213 Neoplastic (dpeaa)DE-He213 Therapy (dpeaa)DE-He213 Otarola, Claudia verfasserin aut Valbuena, Jose verfasserin aut Garrido, Marcelo verfasserin aut Enthalten in International Cancer Conference journal Tokyo : Springer Japan, 2012 2(2012), 1 vom: 15. Nov., Seite 56-61 (DE-627)71861111X (DE-600)2660498-X 2192-3183 nnns volume:2 year:2012 number:1 day:15 month:11 pages:56-61 https://dx.doi.org/10.1007/s13691-012-0065-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 2 2012 1 15 11 56-61
allfieldsGer	10.1007/s13691-012-0065-7 doi (DE-627)SPR032176635 (SPR)s13691-012-0065-7-e DE-627 ger DE-627 rakwb eng 610 ASE Acevedo, Francisco verfasserin aut Metastatic neuroendocrine carcinoma of the colon: response to standard colorectal therapy 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Colorectal neuroendocrine carcinoma (NEC) is a rare disease. There are no prospective randomized studies evaluating the best approach for these patients. Colorectal NEC is frequently treated in a similar way to small-cell cancers, because of its histologic appearance. We report a case of metastatic colorectal NEC which was treated with standard chemotherapy for metastatic colonic adenocarcinoma, including biological agents. A 47-year-old woman, with an unremarkable past medical history, presented to the emergency room complaining of a five-day history of abdominal distension, diffuse crampy pain, and vomiting. An abdominal computed tomography scan showed an obstructive tumor in the descending colon associated with multiple focal hepatic lesions. On the same day, she underwent an emergency laparotomy. A histologic examination revealed a tumor composed of malignant small and medium-sized cells with scant cytoplasm and immunoreactivity to chromogranin and synaptophysin consistent with a diagnosis of NEC. Six out of 20 excised lymph nodes were compromised, and a biopsy of the hepatic lesion showed similar features to the primary tumor. She later received palliative chemotherapy with 5-fluorouracil/leucovorin plus oxaliplatin (FOLFOX) and bevacizumab every other week, completing six cycles. At the end of the treatment she showed clinical improvement and partial response by imaging studies without significant toxicities. We emphasize the report on the treatment received by this patient and the need for further investigation on this matter. Colorectal (dpeaa)DE-He213 Neuroendocrine (dpeaa)DE-He213 Neoplastic (dpeaa)DE-He213 Therapy (dpeaa)DE-He213 Otarola, Claudia verfasserin aut Valbuena, Jose verfasserin aut Garrido, Marcelo verfasserin aut Enthalten in International Cancer Conference journal Tokyo : Springer Japan, 2012 2(2012), 1 vom: 15. Nov., Seite 56-61 (DE-627)71861111X (DE-600)2660498-X 2192-3183 nnns volume:2 year:2012 number:1 day:15 month:11 pages:56-61 https://dx.doi.org/10.1007/s13691-012-0065-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 2 2012 1 15 11 56-61
allfieldsSound	10.1007/s13691-012-0065-7 doi (DE-627)SPR032176635 (SPR)s13691-012-0065-7-e DE-627 ger DE-627 rakwb eng 610 ASE Acevedo, Francisco verfasserin aut Metastatic neuroendocrine carcinoma of the colon: response to standard colorectal therapy 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Colorectal neuroendocrine carcinoma (NEC) is a rare disease. There are no prospective randomized studies evaluating the best approach for these patients. Colorectal NEC is frequently treated in a similar way to small-cell cancers, because of its histologic appearance. We report a case of metastatic colorectal NEC which was treated with standard chemotherapy for metastatic colonic adenocarcinoma, including biological agents. A 47-year-old woman, with an unremarkable past medical history, presented to the emergency room complaining of a five-day history of abdominal distension, diffuse crampy pain, and vomiting. An abdominal computed tomography scan showed an obstructive tumor in the descending colon associated with multiple focal hepatic lesions. On the same day, she underwent an emergency laparotomy. A histologic examination revealed a tumor composed of malignant small and medium-sized cells with scant cytoplasm and immunoreactivity to chromogranin and synaptophysin consistent with a diagnosis of NEC. Six out of 20 excised lymph nodes were compromised, and a biopsy of the hepatic lesion showed similar features to the primary tumor. She later received palliative chemotherapy with 5-fluorouracil/leucovorin plus oxaliplatin (FOLFOX) and bevacizumab every other week, completing six cycles. At the end of the treatment she showed clinical improvement and partial response by imaging studies without significant toxicities. We emphasize the report on the treatment received by this patient and the need for further investigation on this matter. Colorectal (dpeaa)DE-He213 Neuroendocrine (dpeaa)DE-He213 Neoplastic (dpeaa)DE-He213 Therapy (dpeaa)DE-He213 Otarola, Claudia verfasserin aut Valbuena, Jose verfasserin aut Garrido, Marcelo verfasserin aut Enthalten in International Cancer Conference journal Tokyo : Springer Japan, 2012 2(2012), 1 vom: 15. Nov., Seite 56-61 (DE-627)71861111X (DE-600)2660498-X 2192-3183 nnns volume:2 year:2012 number:1 day:15 month:11 pages:56-61 https://dx.doi.org/10.1007/s13691-012-0065-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 2 2012 1 15 11 56-61
language	English
source	Enthalten in International Cancer Conference journal 2(2012), 1 vom: 15. Nov., Seite 56-61 volume:2 year:2012 number:1 day:15 month:11 pages:56-61
sourceStr	Enthalten in International Cancer Conference journal 2(2012), 1 vom: 15. Nov., Seite 56-61 volume:2 year:2012 number:1 day:15 month:11 pages:56-61
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Colorectal Neuroendocrine Neoplastic Therapy
dewey-raw	610
isfreeaccess_bool	false
container_title	International Cancer Conference journal
authorswithroles_txt_mv	Acevedo, Francisco @@aut@@ Otarola, Claudia @@aut@@ Valbuena, Jose @@aut@@ Garrido, Marcelo @@aut@@
publishDateDaySort_date	2012-11-15T00:00:00Z
hierarchy_top_id	71861111X
dewey-sort	3610
id	SPR032176635
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR032176635</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519193309.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201007s2012 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s13691-012-0065-7</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR032176635</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s13691-012-0065-7-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Acevedo, Francisco</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Metastatic neuroendocrine carcinoma of the colon: response to standard colorectal therapy</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2012</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Colorectal neuroendocrine carcinoma (NEC) is a rare disease. 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Six out of 20 excised lymph nodes were compromised, and a biopsy of the hepatic lesion showed similar features to the primary tumor. She later received palliative chemotherapy with 5-fluorouracil/leucovorin plus oxaliplatin (FOLFOX) and bevacizumab every other week, completing six cycles. At the end of the treatment she showed clinical improvement and partial response by imaging studies without significant toxicities. 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author	Acevedo, Francisco
spellingShingle	Acevedo, Francisco ddc 610 misc Colorectal misc Neuroendocrine misc Neoplastic misc Therapy Metastatic neuroendocrine carcinoma of the colon: response to standard colorectal therapy
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topic_title	610 ASE Metastatic neuroendocrine carcinoma of the colon: response to standard colorectal therapy Colorectal (dpeaa)DE-He213 Neuroendocrine (dpeaa)DE-He213 Neoplastic (dpeaa)DE-He213 Therapy (dpeaa)DE-He213
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title	Metastatic neuroendocrine carcinoma of the colon: response to standard colorectal therapy
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title_full	Metastatic neuroendocrine carcinoma of the colon: response to standard colorectal therapy
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author_browse	Acevedo, Francisco Otarola, Claudia Valbuena, Jose Garrido, Marcelo
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title_sort	metastatic neuroendocrine carcinoma of the colon: response to standard colorectal therapy
title_auth	Metastatic neuroendocrine carcinoma of the colon: response to standard colorectal therapy
abstract	Abstract Colorectal neuroendocrine carcinoma (NEC) is a rare disease. There are no prospective randomized studies evaluating the best approach for these patients. Colorectal NEC is frequently treated in a similar way to small-cell cancers, because of its histologic appearance. We report a case of metastatic colorectal NEC which was treated with standard chemotherapy for metastatic colonic adenocarcinoma, including biological agents. A 47-year-old woman, with an unremarkable past medical history, presented to the emergency room complaining of a five-day history of abdominal distension, diffuse crampy pain, and vomiting. An abdominal computed tomography scan showed an obstructive tumor in the descending colon associated with multiple focal hepatic lesions. On the same day, she underwent an emergency laparotomy. A histologic examination revealed a tumor composed of malignant small and medium-sized cells with scant cytoplasm and immunoreactivity to chromogranin and synaptophysin consistent with a diagnosis of NEC. Six out of 20 excised lymph nodes were compromised, and a biopsy of the hepatic lesion showed similar features to the primary tumor. She later received palliative chemotherapy with 5-fluorouracil/leucovorin plus oxaliplatin (FOLFOX) and bevacizumab every other week, completing six cycles. At the end of the treatment she showed clinical improvement and partial response by imaging studies without significant toxicities. We emphasize the report on the treatment received by this patient and the need for further investigation on this matter.
abstractGer	Abstract Colorectal neuroendocrine carcinoma (NEC) is a rare disease. There are no prospective randomized studies evaluating the best approach for these patients. Colorectal NEC is frequently treated in a similar way to small-cell cancers, because of its histologic appearance. We report a case of metastatic colorectal NEC which was treated with standard chemotherapy for metastatic colonic adenocarcinoma, including biological agents. A 47-year-old woman, with an unremarkable past medical history, presented to the emergency room complaining of a five-day history of abdominal distension, diffuse crampy pain, and vomiting. An abdominal computed tomography scan showed an obstructive tumor in the descending colon associated with multiple focal hepatic lesions. On the same day, she underwent an emergency laparotomy. A histologic examination revealed a tumor composed of malignant small and medium-sized cells with scant cytoplasm and immunoreactivity to chromogranin and synaptophysin consistent with a diagnosis of NEC. Six out of 20 excised lymph nodes were compromised, and a biopsy of the hepatic lesion showed similar features to the primary tumor. She later received palliative chemotherapy with 5-fluorouracil/leucovorin plus oxaliplatin (FOLFOX) and bevacizumab every other week, completing six cycles. At the end of the treatment she showed clinical improvement and partial response by imaging studies without significant toxicities. We emphasize the report on the treatment received by this patient and the need for further investigation on this matter.
abstract_unstemmed	Abstract Colorectal neuroendocrine carcinoma (NEC) is a rare disease. There are no prospective randomized studies evaluating the best approach for these patients. Colorectal NEC is frequently treated in a similar way to small-cell cancers, because of its histologic appearance. We report a case of metastatic colorectal NEC which was treated with standard chemotherapy for metastatic colonic adenocarcinoma, including biological agents. A 47-year-old woman, with an unremarkable past medical history, presented to the emergency room complaining of a five-day history of abdominal distension, diffuse crampy pain, and vomiting. An abdominal computed tomography scan showed an obstructive tumor in the descending colon associated with multiple focal hepatic lesions. On the same day, she underwent an emergency laparotomy. A histologic examination revealed a tumor composed of malignant small and medium-sized cells with scant cytoplasm and immunoreactivity to chromogranin and synaptophysin consistent with a diagnosis of NEC. Six out of 20 excised lymph nodes were compromised, and a biopsy of the hepatic lesion showed similar features to the primary tumor. She later received palliative chemotherapy with 5-fluorouracil/leucovorin plus oxaliplatin (FOLFOX) and bevacizumab every other week, completing six cycles. At the end of the treatment she showed clinical improvement and partial response by imaging studies without significant toxicities. We emphasize the report on the treatment received by this patient and the need for further investigation on this matter.
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container_issue	1
title_short	Metastatic neuroendocrine carcinoma of the colon: response to standard colorectal therapy
url	https://dx.doi.org/10.1007/s13691-012-0065-7
remote_bool	true
author2	Otarola, Claudia Valbuena, Jose Garrido, Marcelo
author2Str	Otarola, Claudia Valbuena, Jose Garrido, Marcelo
ppnlink	71861111X
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isOA_txt	false
hochschulschrift_bool	false
doi_str	10.1007/s13691-012-0065-7
up_date	2024-07-04T02:38:42.101Z
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Metastatic neuroendocrine carcinoma of the colon: response to standard colorectal therapy

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