Successful third-line chemotherapy for an adult with recurrent medulloblastoma

Abstract Medulloblastoma is a rare tumor in adults. There is no standard treatment, and extrapolation of treatment results from the pediatric population is flawed by differences in behavior of the tumor and in tolerance of treatment at different ages. In this case report, a patient with medulloblast...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	De Vos, Filip Yves [verfasserIn] Kaal, Suzanne E. [verfasserIn] Wesseling, Pieter [verfasserIn] Gijtenbeek, Johanna M. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	Adult medulloblastoma Recurrent Chemotherapy

Übergeordnetes Werk:	Enthalten in: International Cancer Conference journal - Tokyo : Springer Japan, 2012, 3(2013), 1 vom: 28. Mai, Seite 32-37
Übergeordnetes Werk:	volume:3 ; year:2013 ; number:1 ; day:28 ; month:05 ; pages:32-37

Links:	Volltext

DOI / URN:	10.1007/s13691-013-0111-0

Katalog-ID:	SPR03217716X

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520			\|a Abstract Medulloblastoma is a rare tumor in adults. There is no standard treatment, and extrapolation of treatment results from the pediatric population is flawed by differences in behavior of the tumor and in tolerance of treatment at different ages. In this case report, a patient with medulloblastoma and leptomeningeal metastases after standard chemoradiotherapy had rapid progressive disease after second-line temozolomide. However, partial response was achieved with third-line etoposide and carboplatin. Treatment choice should be based on toxicity management and the patient’s history to obtain higher efficacy, as in our case.
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allfields	10.1007/s13691-013-0111-0 doi (DE-627)SPR03217716X (SPR)s13691-013-0111-0-e DE-627 ger DE-627 rakwb eng 610 ASE De Vos, Filip Yves verfasserin aut Successful third-line chemotherapy for an adult with recurrent medulloblastoma 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Medulloblastoma is a rare tumor in adults. There is no standard treatment, and extrapolation of treatment results from the pediatric population is flawed by differences in behavior of the tumor and in tolerance of treatment at different ages. In this case report, a patient with medulloblastoma and leptomeningeal metastases after standard chemoradiotherapy had rapid progressive disease after second-line temozolomide. However, partial response was achieved with third-line etoposide and carboplatin. Treatment choice should be based on toxicity management and the patient’s history to obtain higher efficacy, as in our case. Adult medulloblastoma (dpeaa)DE-He213 Recurrent (dpeaa)DE-He213 Chemotherapy (dpeaa)DE-He213 Kaal, Suzanne E. verfasserin aut Wesseling, Pieter verfasserin aut Gijtenbeek, Johanna M. verfasserin aut Enthalten in International Cancer Conference journal Tokyo : Springer Japan, 2012 3(2013), 1 vom: 28. Mai, Seite 32-37 (DE-627)71861111X (DE-600)2660498-X 2192-3183 nnns volume:3 year:2013 number:1 day:28 month:05 pages:32-37 https://dx.doi.org/10.1007/s13691-013-0111-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 3 2013 1 28 05 32-37
spelling	10.1007/s13691-013-0111-0 doi (DE-627)SPR03217716X (SPR)s13691-013-0111-0-e DE-627 ger DE-627 rakwb eng 610 ASE De Vos, Filip Yves verfasserin aut Successful third-line chemotherapy for an adult with recurrent medulloblastoma 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Medulloblastoma is a rare tumor in adults. There is no standard treatment, and extrapolation of treatment results from the pediatric population is flawed by differences in behavior of the tumor and in tolerance of treatment at different ages. In this case report, a patient with medulloblastoma and leptomeningeal metastases after standard chemoradiotherapy had rapid progressive disease after second-line temozolomide. However, partial response was achieved with third-line etoposide and carboplatin. Treatment choice should be based on toxicity management and the patient’s history to obtain higher efficacy, as in our case. Adult medulloblastoma (dpeaa)DE-He213 Recurrent (dpeaa)DE-He213 Chemotherapy (dpeaa)DE-He213 Kaal, Suzanne E. verfasserin aut Wesseling, Pieter verfasserin aut Gijtenbeek, Johanna M. verfasserin aut Enthalten in International Cancer Conference journal Tokyo : Springer Japan, 2012 3(2013), 1 vom: 28. Mai, Seite 32-37 (DE-627)71861111X (DE-600)2660498-X 2192-3183 nnns volume:3 year:2013 number:1 day:28 month:05 pages:32-37 https://dx.doi.org/10.1007/s13691-013-0111-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 3 2013 1 28 05 32-37
allfields_unstemmed	10.1007/s13691-013-0111-0 doi (DE-627)SPR03217716X (SPR)s13691-013-0111-0-e DE-627 ger DE-627 rakwb eng 610 ASE De Vos, Filip Yves verfasserin aut Successful third-line chemotherapy for an adult with recurrent medulloblastoma 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Medulloblastoma is a rare tumor in adults. There is no standard treatment, and extrapolation of treatment results from the pediatric population is flawed by differences in behavior of the tumor and in tolerance of treatment at different ages. In this case report, a patient with medulloblastoma and leptomeningeal metastases after standard chemoradiotherapy had rapid progressive disease after second-line temozolomide. However, partial response was achieved with third-line etoposide and carboplatin. Treatment choice should be based on toxicity management and the patient’s history to obtain higher efficacy, as in our case. Adult medulloblastoma (dpeaa)DE-He213 Recurrent (dpeaa)DE-He213 Chemotherapy (dpeaa)DE-He213 Kaal, Suzanne E. verfasserin aut Wesseling, Pieter verfasserin aut Gijtenbeek, Johanna M. verfasserin aut Enthalten in International Cancer Conference journal Tokyo : Springer Japan, 2012 3(2013), 1 vom: 28. Mai, Seite 32-37 (DE-627)71861111X (DE-600)2660498-X 2192-3183 nnns volume:3 year:2013 number:1 day:28 month:05 pages:32-37 https://dx.doi.org/10.1007/s13691-013-0111-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 3 2013 1 28 05 32-37
allfieldsGer	10.1007/s13691-013-0111-0 doi (DE-627)SPR03217716X (SPR)s13691-013-0111-0-e DE-627 ger DE-627 rakwb eng 610 ASE De Vos, Filip Yves verfasserin aut Successful third-line chemotherapy for an adult with recurrent medulloblastoma 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Medulloblastoma is a rare tumor in adults. There is no standard treatment, and extrapolation of treatment results from the pediatric population is flawed by differences in behavior of the tumor and in tolerance of treatment at different ages. In this case report, a patient with medulloblastoma and leptomeningeal metastases after standard chemoradiotherapy had rapid progressive disease after second-line temozolomide. However, partial response was achieved with third-line etoposide and carboplatin. Treatment choice should be based on toxicity management and the patient’s history to obtain higher efficacy, as in our case. Adult medulloblastoma (dpeaa)DE-He213 Recurrent (dpeaa)DE-He213 Chemotherapy (dpeaa)DE-He213 Kaal, Suzanne E. verfasserin aut Wesseling, Pieter verfasserin aut Gijtenbeek, Johanna M. verfasserin aut Enthalten in International Cancer Conference journal Tokyo : Springer Japan, 2012 3(2013), 1 vom: 28. Mai, Seite 32-37 (DE-627)71861111X (DE-600)2660498-X 2192-3183 nnns volume:3 year:2013 number:1 day:28 month:05 pages:32-37 https://dx.doi.org/10.1007/s13691-013-0111-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 3 2013 1 28 05 32-37
allfieldsSound	10.1007/s13691-013-0111-0 doi (DE-627)SPR03217716X (SPR)s13691-013-0111-0-e DE-627 ger DE-627 rakwb eng 610 ASE De Vos, Filip Yves verfasserin aut Successful third-line chemotherapy for an adult with recurrent medulloblastoma 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Medulloblastoma is a rare tumor in adults. There is no standard treatment, and extrapolation of treatment results from the pediatric population is flawed by differences in behavior of the tumor and in tolerance of treatment at different ages. In this case report, a patient with medulloblastoma and leptomeningeal metastases after standard chemoradiotherapy had rapid progressive disease after second-line temozolomide. However, partial response was achieved with third-line etoposide and carboplatin. Treatment choice should be based on toxicity management and the patient’s history to obtain higher efficacy, as in our case. Adult medulloblastoma (dpeaa)DE-He213 Recurrent (dpeaa)DE-He213 Chemotherapy (dpeaa)DE-He213 Kaal, Suzanne E. verfasserin aut Wesseling, Pieter verfasserin aut Gijtenbeek, Johanna M. verfasserin aut Enthalten in International Cancer Conference journal Tokyo : Springer Japan, 2012 3(2013), 1 vom: 28. Mai, Seite 32-37 (DE-627)71861111X (DE-600)2660498-X 2192-3183 nnns volume:3 year:2013 number:1 day:28 month:05 pages:32-37 https://dx.doi.org/10.1007/s13691-013-0111-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 3 2013 1 28 05 32-37
language	English
source	Enthalten in International Cancer Conference journal 3(2013), 1 vom: 28. Mai, Seite 32-37 volume:3 year:2013 number:1 day:28 month:05 pages:32-37
sourceStr	Enthalten in International Cancer Conference journal 3(2013), 1 vom: 28. Mai, Seite 32-37 volume:3 year:2013 number:1 day:28 month:05 pages:32-37
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Adult medulloblastoma Recurrent Chemotherapy
dewey-raw	610
isfreeaccess_bool	false
container_title	International Cancer Conference journal
authorswithroles_txt_mv	De Vos, Filip Yves @@aut@@ Kaal, Suzanne E. @@aut@@ Wesseling, Pieter @@aut@@ Gijtenbeek, Johanna M. @@aut@@
publishDateDaySort_date	2013-05-28T00:00:00Z
hierarchy_top_id	71861111X
dewey-sort	3610
id	SPR03217716X
language_de	englisch
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author	De Vos, Filip Yves
spellingShingle	De Vos, Filip Yves ddc 610 misc Adult medulloblastoma misc Recurrent misc Chemotherapy Successful third-line chemotherapy for an adult with recurrent medulloblastoma
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topic_title	610 ASE Successful third-line chemotherapy for an adult with recurrent medulloblastoma Adult medulloblastoma (dpeaa)DE-He213 Recurrent (dpeaa)DE-He213 Chemotherapy (dpeaa)DE-He213
topic	ddc 610 misc Adult medulloblastoma misc Recurrent misc Chemotherapy
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title	Successful third-line chemotherapy for an adult with recurrent medulloblastoma
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title_full	Successful third-line chemotherapy for an adult with recurrent medulloblastoma
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author_browse	De Vos, Filip Yves Kaal, Suzanne E. Wesseling, Pieter Gijtenbeek, Johanna M.
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title_sort	successful third-line chemotherapy for an adult with recurrent medulloblastoma
title_auth	Successful third-line chemotherapy for an adult with recurrent medulloblastoma
abstract	Abstract Medulloblastoma is a rare tumor in adults. There is no standard treatment, and extrapolation of treatment results from the pediatric population is flawed by differences in behavior of the tumor and in tolerance of treatment at different ages. In this case report, a patient with medulloblastoma and leptomeningeal metastases after standard chemoradiotherapy had rapid progressive disease after second-line temozolomide. However, partial response was achieved with third-line etoposide and carboplatin. Treatment choice should be based on toxicity management and the patient’s history to obtain higher efficacy, as in our case.
abstractGer	Abstract Medulloblastoma is a rare tumor in adults. There is no standard treatment, and extrapolation of treatment results from the pediatric population is flawed by differences in behavior of the tumor and in tolerance of treatment at different ages. In this case report, a patient with medulloblastoma and leptomeningeal metastases after standard chemoradiotherapy had rapid progressive disease after second-line temozolomide. However, partial response was achieved with third-line etoposide and carboplatin. Treatment choice should be based on toxicity management and the patient’s history to obtain higher efficacy, as in our case.
abstract_unstemmed	Abstract Medulloblastoma is a rare tumor in adults. There is no standard treatment, and extrapolation of treatment results from the pediatric population is flawed by differences in behavior of the tumor and in tolerance of treatment at different ages. In this case report, a patient with medulloblastoma and leptomeningeal metastases after standard chemoradiotherapy had rapid progressive disease after second-line temozolomide. However, partial response was achieved with third-line etoposide and carboplatin. Treatment choice should be based on toxicity management and the patient’s history to obtain higher efficacy, as in our case.
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title_short	Successful third-line chemotherapy for an adult with recurrent medulloblastoma
url	https://dx.doi.org/10.1007/s13691-013-0111-0
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author2	Kaal, Suzanne E. Wesseling, Pieter Gijtenbeek, Johanna M.
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up_date	2024-07-04T02:38:49.663Z
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Successful third-line chemotherapy for an adult with recurrent medulloblastoma

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