Early economic evaluation of emerging health technologies: protocol of a systematic review

Background The concept of early health technology assessment, discussed well over a decade, has now been collaboratively implemented by industry, government, and academia to select and expedite the development of emerging technologies that may address the needs of patients and health systems. Early economic evaluation is essential to assess the value of emerging technologies, but empirical data to inform the current practice of early evaluation is limited. We propose a systematic review of early economic evaluation studies in order to better understand the current practice. Methods/design This protocol describes a systematic review of economic evaluation studies of regulated health technologies in which the evaluation is conducted prior to regulatory approval and when the technology effectiveness is not well established. Included studies must report an economic evaluation, defined as the comparative analysis of alternatives with respect to their associated costs and health consequences, and must evaluate some regulated health technology such as pharmaceuticals, biologics, high-risk medical devices, or biomarkers. We will conduct the literature search on multiple databases, including MEDLINE, EMBASE, the Centre for Reviews and Dissemination Databases, and EconLit. Additional citations will be identified via scanning reference lists and author searching. We suspect that many early economic evaluation studies are unpublished, especially those conducted for internal use only. Additionally, we use a chain-referral sampling approach to identify authors of unpublished studies who work in technology discovery and development, starting out with our contact lists and authors who published relevant studies. Citation screening and full-text review will be conducted by pairs of reviewers. Abstracted data will include those related to the decision context and decision problem of the early evaluation, evaluation methods (e.g., data sources, methods, and assumptions used to identify, measure, and value the likely effectiveness and the costs and consequences of the new technology, handling of uncertainty), and whether the study results adequately address the main study question or objective. Data will be summarized overall and stratified by publication status. Discussion This study is timely to inform early economic evaluation practice, given the international trend in early health technology assessment initiatives. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Pham, Ba’ [verfasserIn] Tu, Hong Anh Thi [verfasserIn] Han, Dolly [verfasserIn] Pechlivanoglou, Petros [verfasserIn] Miller, Fiona [verfasserIn] Rac, Valeria [verfasserIn] Chin, Warren [verfasserIn] Tricco, Andrea C [verfasserIn] Paulden, Mike [verfasserIn] Bielecki, Joanna [verfasserIn] Krahn, Murray [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	Economic Evaluation Health Technology Assessment Early Evaluation Economic Evaluation Study National Health Service Economic Evaluation

Übergeordnetes Werk:	Enthalten in: Systematic Reviews - London : Biomed Central, 2012, 3(2014), 1 vom: 23. Juli
Übergeordnetes Werk:	volume:3 ; year:2014 ; number:1 ; day:23 ; month:07

Links:	Volltext

DOI / URN:	10.1186/2046-4053-3-81

Katalog-ID:	SPR032189699

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520			\|a Background The concept of early health technology assessment, discussed well over a decade, has now been collaboratively implemented by industry, government, and academia to select and expedite the development of emerging technologies that may address the needs of patients and health systems. Early economic evaluation is essential to assess the value of emerging technologies, but empirical data to inform the current practice of early evaluation is limited. We propose a systematic review of early economic evaluation studies in order to better understand the current practice. Methods/design This protocol describes a systematic review of economic evaluation studies of regulated health technologies in which the evaluation is conducted prior to regulatory approval and when the technology effectiveness is not well established. Included studies must report an economic evaluation, defined as the comparative analysis of alternatives with respect to their associated costs and health consequences, and must evaluate some regulated health technology such as pharmaceuticals, biologics, high-risk medical devices, or biomarkers. We will conduct the literature search on multiple databases, including MEDLINE, EMBASE, the Centre for Reviews and Dissemination Databases, and EconLit. Additional citations will be identified via scanning reference lists and author searching. We suspect that many early economic evaluation studies are unpublished, especially those conducted for internal use only. Additionally, we use a chain-referral sampling approach to identify authors of unpublished studies who work in technology discovery and development, starting out with our contact lists and authors who published relevant studies. Citation screening and full-text review will be conducted by pairs of reviewers. Abstracted data will include those related to the decision context and decision problem of the early evaluation, evaluation methods (e.g., data sources, methods, and assumptions used to identify, measure, and value the likely effectiveness and the costs and consequences of the new technology, handling of uncertainty), and whether the study results adequately address the main study question or objective. Data will be summarized overall and stratified by publication status. Discussion This study is timely to inform early economic evaluation practice, given the international trend in early health technology assessment initiatives.
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allfields	10.1186/2046-4053-3-81 doi (DE-627)SPR032189699 (SPR)2046-4053-3-81-e DE-627 ger DE-627 rakwb eng 610 ASE Pham, Ba’ verfasserin aut Early economic evaluation of emerging health technologies: protocol of a systematic review 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The concept of early health technology assessment, discussed well over a decade, has now been collaboratively implemented by industry, government, and academia to select and expedite the development of emerging technologies that may address the needs of patients and health systems. Early economic evaluation is essential to assess the value of emerging technologies, but empirical data to inform the current practice of early evaluation is limited. We propose a systematic review of early economic evaluation studies in order to better understand the current practice. Methods/design This protocol describes a systematic review of economic evaluation studies of regulated health technologies in which the evaluation is conducted prior to regulatory approval and when the technology effectiveness is not well established. Included studies must report an economic evaluation, defined as the comparative analysis of alternatives with respect to their associated costs and health consequences, and must evaluate some regulated health technology such as pharmaceuticals, biologics, high-risk medical devices, or biomarkers. We will conduct the literature search on multiple databases, including MEDLINE, EMBASE, the Centre for Reviews and Dissemination Databases, and EconLit. Additional citations will be identified via scanning reference lists and author searching. We suspect that many early economic evaluation studies are unpublished, especially those conducted for internal use only. Additionally, we use a chain-referral sampling approach to identify authors of unpublished studies who work in technology discovery and development, starting out with our contact lists and authors who published relevant studies. Citation screening and full-text review will be conducted by pairs of reviewers. Abstracted data will include those related to the decision context and decision problem of the early evaluation, evaluation methods (e.g., data sources, methods, and assumptions used to identify, measure, and value the likely effectiveness and the costs and consequences of the new technology, handling of uncertainty), and whether the study results adequately address the main study question or objective. Data will be summarized overall and stratified by publication status. Discussion This study is timely to inform early economic evaluation practice, given the international trend in early health technology assessment initiatives. Economic Evaluation (dpeaa)DE-He213 Health Technology Assessment (dpeaa)DE-He213 Early Evaluation (dpeaa)DE-He213 Economic Evaluation Study (dpeaa)DE-He213 National Health Service Economic Evaluation (dpeaa)DE-He213 Tu, Hong Anh Thi verfasserin aut Han, Dolly verfasserin aut Pechlivanoglou, Petros verfasserin aut Miller, Fiona verfasserin aut Rac, Valeria verfasserin aut Chin, Warren verfasserin aut Tricco, Andrea C verfasserin aut Paulden, Mike verfasserin aut Bielecki, Joanna verfasserin aut Krahn, Murray verfasserin aut Enthalten in Systematic Reviews London : Biomed Central, 2012 3(2014), 1 vom: 23. Juli (DE-627)718627210 (DE-600)2662257-9 2046-4053 nnns volume:3 year:2014 number:1 day:23 month:07 https://dx.doi.org/10.1186/2046-4053-3-81 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2014 1 23 07
spelling	10.1186/2046-4053-3-81 doi (DE-627)SPR032189699 (SPR)2046-4053-3-81-e DE-627 ger DE-627 rakwb eng 610 ASE Pham, Ba’ verfasserin aut Early economic evaluation of emerging health technologies: protocol of a systematic review 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The concept of early health technology assessment, discussed well over a decade, has now been collaboratively implemented by industry, government, and academia to select and expedite the development of emerging technologies that may address the needs of patients and health systems. Early economic evaluation is essential to assess the value of emerging technologies, but empirical data to inform the current practice of early evaluation is limited. We propose a systematic review of early economic evaluation studies in order to better understand the current practice. Methods/design This protocol describes a systematic review of economic evaluation studies of regulated health technologies in which the evaluation is conducted prior to regulatory approval and when the technology effectiveness is not well established. Included studies must report an economic evaluation, defined as the comparative analysis of alternatives with respect to their associated costs and health consequences, and must evaluate some regulated health technology such as pharmaceuticals, biologics, high-risk medical devices, or biomarkers. We will conduct the literature search on multiple databases, including MEDLINE, EMBASE, the Centre for Reviews and Dissemination Databases, and EconLit. Additional citations will be identified via scanning reference lists and author searching. We suspect that many early economic evaluation studies are unpublished, especially those conducted for internal use only. Additionally, we use a chain-referral sampling approach to identify authors of unpublished studies who work in technology discovery and development, starting out with our contact lists and authors who published relevant studies. Citation screening and full-text review will be conducted by pairs of reviewers. Abstracted data will include those related to the decision context and decision problem of the early evaluation, evaluation methods (e.g., data sources, methods, and assumptions used to identify, measure, and value the likely effectiveness and the costs and consequences of the new technology, handling of uncertainty), and whether the study results adequately address the main study question or objective. Data will be summarized overall and stratified by publication status. Discussion This study is timely to inform early economic evaluation practice, given the international trend in early health technology assessment initiatives. Economic Evaluation (dpeaa)DE-He213 Health Technology Assessment (dpeaa)DE-He213 Early Evaluation (dpeaa)DE-He213 Economic Evaluation Study (dpeaa)DE-He213 National Health Service Economic Evaluation (dpeaa)DE-He213 Tu, Hong Anh Thi verfasserin aut Han, Dolly verfasserin aut Pechlivanoglou, Petros verfasserin aut Miller, Fiona verfasserin aut Rac, Valeria verfasserin aut Chin, Warren verfasserin aut Tricco, Andrea C verfasserin aut Paulden, Mike verfasserin aut Bielecki, Joanna verfasserin aut Krahn, Murray verfasserin aut Enthalten in Systematic Reviews London : Biomed Central, 2012 3(2014), 1 vom: 23. Juli (DE-627)718627210 (DE-600)2662257-9 2046-4053 nnns volume:3 year:2014 number:1 day:23 month:07 https://dx.doi.org/10.1186/2046-4053-3-81 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2014 1 23 07
allfields_unstemmed	10.1186/2046-4053-3-81 doi (DE-627)SPR032189699 (SPR)2046-4053-3-81-e DE-627 ger DE-627 rakwb eng 610 ASE Pham, Ba’ verfasserin aut Early economic evaluation of emerging health technologies: protocol of a systematic review 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The concept of early health technology assessment, discussed well over a decade, has now been collaboratively implemented by industry, government, and academia to select and expedite the development of emerging technologies that may address the needs of patients and health systems. Early economic evaluation is essential to assess the value of emerging technologies, but empirical data to inform the current practice of early evaluation is limited. We propose a systematic review of early economic evaluation studies in order to better understand the current practice. Methods/design This protocol describes a systematic review of economic evaluation studies of regulated health technologies in which the evaluation is conducted prior to regulatory approval and when the technology effectiveness is not well established. Included studies must report an economic evaluation, defined as the comparative analysis of alternatives with respect to their associated costs and health consequences, and must evaluate some regulated health technology such as pharmaceuticals, biologics, high-risk medical devices, or biomarkers. We will conduct the literature search on multiple databases, including MEDLINE, EMBASE, the Centre for Reviews and Dissemination Databases, and EconLit. Additional citations will be identified via scanning reference lists and author searching. We suspect that many early economic evaluation studies are unpublished, especially those conducted for internal use only. Additionally, we use a chain-referral sampling approach to identify authors of unpublished studies who work in technology discovery and development, starting out with our contact lists and authors who published relevant studies. Citation screening and full-text review will be conducted by pairs of reviewers. Abstracted data will include those related to the decision context and decision problem of the early evaluation, evaluation methods (e.g., data sources, methods, and assumptions used to identify, measure, and value the likely effectiveness and the costs and consequences of the new technology, handling of uncertainty), and whether the study results adequately address the main study question or objective. Data will be summarized overall and stratified by publication status. Discussion This study is timely to inform early economic evaluation practice, given the international trend in early health technology assessment initiatives. Economic Evaluation (dpeaa)DE-He213 Health Technology Assessment (dpeaa)DE-He213 Early Evaluation (dpeaa)DE-He213 Economic Evaluation Study (dpeaa)DE-He213 National Health Service Economic Evaluation (dpeaa)DE-He213 Tu, Hong Anh Thi verfasserin aut Han, Dolly verfasserin aut Pechlivanoglou, Petros verfasserin aut Miller, Fiona verfasserin aut Rac, Valeria verfasserin aut Chin, Warren verfasserin aut Tricco, Andrea C verfasserin aut Paulden, Mike verfasserin aut Bielecki, Joanna verfasserin aut Krahn, Murray verfasserin aut Enthalten in Systematic Reviews London : Biomed Central, 2012 3(2014), 1 vom: 23. Juli (DE-627)718627210 (DE-600)2662257-9 2046-4053 nnns volume:3 year:2014 number:1 day:23 month:07 https://dx.doi.org/10.1186/2046-4053-3-81 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2014 1 23 07
allfieldsGer	10.1186/2046-4053-3-81 doi (DE-627)SPR032189699 (SPR)2046-4053-3-81-e DE-627 ger DE-627 rakwb eng 610 ASE Pham, Ba’ verfasserin aut Early economic evaluation of emerging health technologies: protocol of a systematic review 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The concept of early health technology assessment, discussed well over a decade, has now been collaboratively implemented by industry, government, and academia to select and expedite the development of emerging technologies that may address the needs of patients and health systems. Early economic evaluation is essential to assess the value of emerging technologies, but empirical data to inform the current practice of early evaluation is limited. We propose a systematic review of early economic evaluation studies in order to better understand the current practice. Methods/design This protocol describes a systematic review of economic evaluation studies of regulated health technologies in which the evaluation is conducted prior to regulatory approval and when the technology effectiveness is not well established. Included studies must report an economic evaluation, defined as the comparative analysis of alternatives with respect to their associated costs and health consequences, and must evaluate some regulated health technology such as pharmaceuticals, biologics, high-risk medical devices, or biomarkers. We will conduct the literature search on multiple databases, including MEDLINE, EMBASE, the Centre for Reviews and Dissemination Databases, and EconLit. Additional citations will be identified via scanning reference lists and author searching. We suspect that many early economic evaluation studies are unpublished, especially those conducted for internal use only. Additionally, we use a chain-referral sampling approach to identify authors of unpublished studies who work in technology discovery and development, starting out with our contact lists and authors who published relevant studies. Citation screening and full-text review will be conducted by pairs of reviewers. Abstracted data will include those related to the decision context and decision problem of the early evaluation, evaluation methods (e.g., data sources, methods, and assumptions used to identify, measure, and value the likely effectiveness and the costs and consequences of the new technology, handling of uncertainty), and whether the study results adequately address the main study question or objective. Data will be summarized overall and stratified by publication status. Discussion This study is timely to inform early economic evaluation practice, given the international trend in early health technology assessment initiatives. Economic Evaluation (dpeaa)DE-He213 Health Technology Assessment (dpeaa)DE-He213 Early Evaluation (dpeaa)DE-He213 Economic Evaluation Study (dpeaa)DE-He213 National Health Service Economic Evaluation (dpeaa)DE-He213 Tu, Hong Anh Thi verfasserin aut Han, Dolly verfasserin aut Pechlivanoglou, Petros verfasserin aut Miller, Fiona verfasserin aut Rac, Valeria verfasserin aut Chin, Warren verfasserin aut Tricco, Andrea C verfasserin aut Paulden, Mike verfasserin aut Bielecki, Joanna verfasserin aut Krahn, Murray verfasserin aut Enthalten in Systematic Reviews London : Biomed Central, 2012 3(2014), 1 vom: 23. Juli (DE-627)718627210 (DE-600)2662257-9 2046-4053 nnns volume:3 year:2014 number:1 day:23 month:07 https://dx.doi.org/10.1186/2046-4053-3-81 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2014 1 23 07
allfieldsSound	10.1186/2046-4053-3-81 doi (DE-627)SPR032189699 (SPR)2046-4053-3-81-e DE-627 ger DE-627 rakwb eng 610 ASE Pham, Ba’ verfasserin aut Early economic evaluation of emerging health technologies: protocol of a systematic review 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The concept of early health technology assessment, discussed well over a decade, has now been collaboratively implemented by industry, government, and academia to select and expedite the development of emerging technologies that may address the needs of patients and health systems. Early economic evaluation is essential to assess the value of emerging technologies, but empirical data to inform the current practice of early evaluation is limited. We propose a systematic review of early economic evaluation studies in order to better understand the current practice. Methods/design This protocol describes a systematic review of economic evaluation studies of regulated health technologies in which the evaluation is conducted prior to regulatory approval and when the technology effectiveness is not well established. Included studies must report an economic evaluation, defined as the comparative analysis of alternatives with respect to their associated costs and health consequences, and must evaluate some regulated health technology such as pharmaceuticals, biologics, high-risk medical devices, or biomarkers. We will conduct the literature search on multiple databases, including MEDLINE, EMBASE, the Centre for Reviews and Dissemination Databases, and EconLit. Additional citations will be identified via scanning reference lists and author searching. We suspect that many early economic evaluation studies are unpublished, especially those conducted for internal use only. Additionally, we use a chain-referral sampling approach to identify authors of unpublished studies who work in technology discovery and development, starting out with our contact lists and authors who published relevant studies. Citation screening and full-text review will be conducted by pairs of reviewers. Abstracted data will include those related to the decision context and decision problem of the early evaluation, evaluation methods (e.g., data sources, methods, and assumptions used to identify, measure, and value the likely effectiveness and the costs and consequences of the new technology, handling of uncertainty), and whether the study results adequately address the main study question or objective. Data will be summarized overall and stratified by publication status. Discussion This study is timely to inform early economic evaluation practice, given the international trend in early health technology assessment initiatives. Economic Evaluation (dpeaa)DE-He213 Health Technology Assessment (dpeaa)DE-He213 Early Evaluation (dpeaa)DE-He213 Economic Evaluation Study (dpeaa)DE-He213 National Health Service Economic Evaluation (dpeaa)DE-He213 Tu, Hong Anh Thi verfasserin aut Han, Dolly verfasserin aut Pechlivanoglou, Petros verfasserin aut Miller, Fiona verfasserin aut Rac, Valeria verfasserin aut Chin, Warren verfasserin aut Tricco, Andrea C verfasserin aut Paulden, Mike verfasserin aut Bielecki, Joanna verfasserin aut Krahn, Murray verfasserin aut Enthalten in Systematic Reviews London : Biomed Central, 2012 3(2014), 1 vom: 23. Juli (DE-627)718627210 (DE-600)2662257-9 2046-4053 nnns volume:3 year:2014 number:1 day:23 month:07 https://dx.doi.org/10.1186/2046-4053-3-81 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2014 1 23 07
language	English
source	Enthalten in Systematic Reviews 3(2014), 1 vom: 23. Juli volume:3 year:2014 number:1 day:23 month:07
sourceStr	Enthalten in Systematic Reviews 3(2014), 1 vom: 23. Juli volume:3 year:2014 number:1 day:23 month:07
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publishDateDaySort_date	2014-07-23T00:00:00Z
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topic_title	610 ASE Early economic evaluation of emerging health technologies: protocol of a systematic review Economic Evaluation (dpeaa)DE-He213 Health Technology Assessment (dpeaa)DE-He213 Early Evaluation (dpeaa)DE-He213 Economic Evaluation Study (dpeaa)DE-He213 National Health Service Economic Evaluation (dpeaa)DE-He213
topic	ddc 610 misc Economic Evaluation misc Health Technology Assessment misc Early Evaluation misc Economic Evaluation Study misc National Health Service Economic Evaluation
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topic_browse	ddc 610 misc Economic Evaluation misc Health Technology Assessment misc Early Evaluation misc Economic Evaluation Study misc National Health Service Economic Evaluation
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title	Early economic evaluation of emerging health technologies: protocol of a systematic review
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title_full	Early economic evaluation of emerging health technologies: protocol of a systematic review
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author_browse	Pham, Ba’ Tu, Hong Anh Thi Han, Dolly Pechlivanoglou, Petros Miller, Fiona Rac, Valeria Chin, Warren Tricco, Andrea C Paulden, Mike Bielecki, Joanna Krahn, Murray
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title_sort	early economic evaluation of emerging health technologies: protocol of a systematic review
title_auth	Early economic evaluation of emerging health technologies: protocol of a systematic review
abstract	Background The concept of early health technology assessment, discussed well over a decade, has now been collaboratively implemented by industry, government, and academia to select and expedite the development of emerging technologies that may address the needs of patients and health systems. Early economic evaluation is essential to assess the value of emerging technologies, but empirical data to inform the current practice of early evaluation is limited. We propose a systematic review of early economic evaluation studies in order to better understand the current practice. Methods/design This protocol describes a systematic review of economic evaluation studies of regulated health technologies in which the evaluation is conducted prior to regulatory approval and when the technology effectiveness is not well established. Included studies must report an economic evaluation, defined as the comparative analysis of alternatives with respect to their associated costs and health consequences, and must evaluate some regulated health technology such as pharmaceuticals, biologics, high-risk medical devices, or biomarkers. We will conduct the literature search on multiple databases, including MEDLINE, EMBASE, the Centre for Reviews and Dissemination Databases, and EconLit. Additional citations will be identified via scanning reference lists and author searching. We suspect that many early economic evaluation studies are unpublished, especially those conducted for internal use only. Additionally, we use a chain-referral sampling approach to identify authors of unpublished studies who work in technology discovery and development, starting out with our contact lists and authors who published relevant studies. Citation screening and full-text review will be conducted by pairs of reviewers. Abstracted data will include those related to the decision context and decision problem of the early evaluation, evaluation methods (e.g., data sources, methods, and assumptions used to identify, measure, and value the likely effectiveness and the costs and consequences of the new technology, handling of uncertainty), and whether the study results adequately address the main study question or objective. Data will be summarized overall and stratified by publication status. Discussion This study is timely to inform early economic evaluation practice, given the international trend in early health technology assessment initiatives.
abstractGer	Background The concept of early health technology assessment, discussed well over a decade, has now been collaboratively implemented by industry, government, and academia to select and expedite the development of emerging technologies that may address the needs of patients and health systems. Early economic evaluation is essential to assess the value of emerging technologies, but empirical data to inform the current practice of early evaluation is limited. We propose a systematic review of early economic evaluation studies in order to better understand the current practice. Methods/design This protocol describes a systematic review of economic evaluation studies of regulated health technologies in which the evaluation is conducted prior to regulatory approval and when the technology effectiveness is not well established. Included studies must report an economic evaluation, defined as the comparative analysis of alternatives with respect to their associated costs and health consequences, and must evaluate some regulated health technology such as pharmaceuticals, biologics, high-risk medical devices, or biomarkers. We will conduct the literature search on multiple databases, including MEDLINE, EMBASE, the Centre for Reviews and Dissemination Databases, and EconLit. Additional citations will be identified via scanning reference lists and author searching. We suspect that many early economic evaluation studies are unpublished, especially those conducted for internal use only. Additionally, we use a chain-referral sampling approach to identify authors of unpublished studies who work in technology discovery and development, starting out with our contact lists and authors who published relevant studies. Citation screening and full-text review will be conducted by pairs of reviewers. Abstracted data will include those related to the decision context and decision problem of the early evaluation, evaluation methods (e.g., data sources, methods, and assumptions used to identify, measure, and value the likely effectiveness and the costs and consequences of the new technology, handling of uncertainty), and whether the study results adequately address the main study question or objective. Data will be summarized overall and stratified by publication status. Discussion This study is timely to inform early economic evaluation practice, given the international trend in early health technology assessment initiatives.
abstract_unstemmed	Background The concept of early health technology assessment, discussed well over a decade, has now been collaboratively implemented by industry, government, and academia to select and expedite the development of emerging technologies that may address the needs of patients and health systems. Early economic evaluation is essential to assess the value of emerging technologies, but empirical data to inform the current practice of early evaluation is limited. We propose a systematic review of early economic evaluation studies in order to better understand the current practice. Methods/design This protocol describes a systematic review of economic evaluation studies of regulated health technologies in which the evaluation is conducted prior to regulatory approval and when the technology effectiveness is not well established. Included studies must report an economic evaluation, defined as the comparative analysis of alternatives with respect to their associated costs and health consequences, and must evaluate some regulated health technology such as pharmaceuticals, biologics, high-risk medical devices, or biomarkers. We will conduct the literature search on multiple databases, including MEDLINE, EMBASE, the Centre for Reviews and Dissemination Databases, and EconLit. Additional citations will be identified via scanning reference lists and author searching. We suspect that many early economic evaluation studies are unpublished, especially those conducted for internal use only. Additionally, we use a chain-referral sampling approach to identify authors of unpublished studies who work in technology discovery and development, starting out with our contact lists and authors who published relevant studies. Citation screening and full-text review will be conducted by pairs of reviewers. Abstracted data will include those related to the decision context and decision problem of the early evaluation, evaluation methods (e.g., data sources, methods, and assumptions used to identify, measure, and value the likely effectiveness and the costs and consequences of the new technology, handling of uncertainty), and whether the study results adequately address the main study question or objective. Data will be summarized overall and stratified by publication status. Discussion This study is timely to inform early economic evaluation practice, given the international trend in early health technology assessment initiatives.
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title_short	Early economic evaluation of emerging health technologies: protocol of a systematic review
url	https://dx.doi.org/10.1186/2046-4053-3-81
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author2	Tu, Hong Anh Thi Han, Dolly Pechlivanoglou, Petros Miller, Fiona Rac, Valeria Chin, Warren Tricco, Andrea C Paulden, Mike Bielecki, Joanna Krahn, Murray
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