Efficacy of vitamin D supplementation in depression in adults: a systematic review protocol

Background The role of vitamin D in management of depression is unclear. Results from observational and emerging randomized controlled trials (RCTs) investigating the efficacy of vitamin D in depression lack consistency - with some suggesting a positive association while others show a negative or in...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Li, Guowei [verfasserIn] Mbuagbaw, Lawrence [verfasserIn] Samaan, Zainab [verfasserIn] Zhang, Shiyuan [verfasserIn] Adachi, Jonathan D [verfasserIn] Papaioannou, Alexandra [verfasserIn] Thabane, Lehana [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	Vitamin D Depression Randomized controlled trial Adults Efficacy Systematic review protocol

Übergeordnetes Werk:	Enthalten in: Systematic Reviews - London : Biomed Central, 2012, 2(2013), 1 vom: 08. Aug.
Übergeordnetes Werk:	volume:2 ; year:2013 ; number:1 ; day:08 ; month:08

Links:	Volltext

DOI / URN:	10.1186/2046-4053-2-64

Katalog-ID:	SPR032287828

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520			\|a Background The role of vitamin D in management of depression is unclear. Results from observational and emerging randomized controlled trials (RCTs) investigating the efficacy of vitamin D in depression lack consistency - with some suggesting a positive association while others show a negative or inconclusive association. Methods/Design The primary aim of this study is to conduct a systematic review of RCTs to assess the effect of oral vitamin D supplementation versus placebo on depression symptoms measured by scales and the proportion of patients with symptomatic improvement according to the authors’ original definition. Secondary aims include assessing the change in quality of life, adverse events and treatment discontinuation. We will conduct the systematic review and meta-analysis according to the recommendations of the Cochrane Handbook for Systematic Reviews of Interventions. We will search the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (1966 to present), EMBASE (1980 to present), CINAHL (1982 to present), PsychINFO (1967 to present) and ClinicalTrials.gov. Unpublished work will be identified by searching two major conferences: the International Vitamin Conference, the Anxiety Disorders and Depression Conference, while grey literature will be acquired by contacting authors of included studies. We will use the random-effects meta-analysis to synthesize the data by pooling the results of included studies. Discussion The results of this systematic review will be helpful in clarifying the efficacy of vitamin D supplementation and providing evidence to establish guidelines for implementation of vitamin D for depression in general practice and other relevant settings. Study registration Unique identifier: CRD42013003849.
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allfields	10.1186/2046-4053-2-64 doi (DE-627)SPR032287828 (SPR)2046-4053-2-64-e DE-627 ger DE-627 rakwb eng 610 ASE Li, Guowei verfasserin aut Efficacy of vitamin D supplementation in depression in adults: a systematic review protocol 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The role of vitamin D in management of depression is unclear. Results from observational and emerging randomized controlled trials (RCTs) investigating the efficacy of vitamin D in depression lack consistency - with some suggesting a positive association while others show a negative or inconclusive association. Methods/Design The primary aim of this study is to conduct a systematic review of RCTs to assess the effect of oral vitamin D supplementation versus placebo on depression symptoms measured by scales and the proportion of patients with symptomatic improvement according to the authors’ original definition. Secondary aims include assessing the change in quality of life, adverse events and treatment discontinuation. We will conduct the systematic review and meta-analysis according to the recommendations of the Cochrane Handbook for Systematic Reviews of Interventions. We will search the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (1966 to present), EMBASE (1980 to present), CINAHL (1982 to present), PsychINFO (1967 to present) and ClinicalTrials.gov. Unpublished work will be identified by searching two major conferences: the International Vitamin Conference, the Anxiety Disorders and Depression Conference, while grey literature will be acquired by contacting authors of included studies. We will use the random-effects meta-analysis to synthesize the data by pooling the results of included studies. Discussion The results of this systematic review will be helpful in clarifying the efficacy of vitamin D supplementation and providing evidence to establish guidelines for implementation of vitamin D for depression in general practice and other relevant settings. Study registration Unique identifier: CRD42013003849. Vitamin D (dpeaa)DE-He213 Depression (dpeaa)DE-He213 Randomized controlled trial (dpeaa)DE-He213 Adults (dpeaa)DE-He213 Efficacy (dpeaa)DE-He213 Systematic review protocol (dpeaa)DE-He213 Mbuagbaw, Lawrence verfasserin aut Samaan, Zainab verfasserin aut Zhang, Shiyuan verfasserin aut Adachi, Jonathan D verfasserin aut Papaioannou, Alexandra verfasserin aut Thabane, Lehana verfasserin aut Enthalten in Systematic Reviews London : Biomed Central, 2012 2(2013), 1 vom: 08. Aug. (DE-627)718627210 (DE-600)2662257-9 2046-4053 nnns volume:2 year:2013 number:1 day:08 month:08 https://dx.doi.org/10.1186/2046-4053-2-64 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2013 1 08 08
spelling	10.1186/2046-4053-2-64 doi (DE-627)SPR032287828 (SPR)2046-4053-2-64-e DE-627 ger DE-627 rakwb eng 610 ASE Li, Guowei verfasserin aut Efficacy of vitamin D supplementation in depression in adults: a systematic review protocol 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The role of vitamin D in management of depression is unclear. Results from observational and emerging randomized controlled trials (RCTs) investigating the efficacy of vitamin D in depression lack consistency - with some suggesting a positive association while others show a negative or inconclusive association. Methods/Design The primary aim of this study is to conduct a systematic review of RCTs to assess the effect of oral vitamin D supplementation versus placebo on depression symptoms measured by scales and the proportion of patients with symptomatic improvement according to the authors’ original definition. Secondary aims include assessing the change in quality of life, adverse events and treatment discontinuation. We will conduct the systematic review and meta-analysis according to the recommendations of the Cochrane Handbook for Systematic Reviews of Interventions. We will search the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (1966 to present), EMBASE (1980 to present), CINAHL (1982 to present), PsychINFO (1967 to present) and ClinicalTrials.gov. Unpublished work will be identified by searching two major conferences: the International Vitamin Conference, the Anxiety Disorders and Depression Conference, while grey literature will be acquired by contacting authors of included studies. We will use the random-effects meta-analysis to synthesize the data by pooling the results of included studies. Discussion The results of this systematic review will be helpful in clarifying the efficacy of vitamin D supplementation and providing evidence to establish guidelines for implementation of vitamin D for depression in general practice and other relevant settings. Study registration Unique identifier: CRD42013003849. Vitamin D (dpeaa)DE-He213 Depression (dpeaa)DE-He213 Randomized controlled trial (dpeaa)DE-He213 Adults (dpeaa)DE-He213 Efficacy (dpeaa)DE-He213 Systematic review protocol (dpeaa)DE-He213 Mbuagbaw, Lawrence verfasserin aut Samaan, Zainab verfasserin aut Zhang, Shiyuan verfasserin aut Adachi, Jonathan D verfasserin aut Papaioannou, Alexandra verfasserin aut Thabane, Lehana verfasserin aut Enthalten in Systematic Reviews London : Biomed Central, 2012 2(2013), 1 vom: 08. Aug. (DE-627)718627210 (DE-600)2662257-9 2046-4053 nnns volume:2 year:2013 number:1 day:08 month:08 https://dx.doi.org/10.1186/2046-4053-2-64 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2013 1 08 08
allfields_unstemmed	10.1186/2046-4053-2-64 doi (DE-627)SPR032287828 (SPR)2046-4053-2-64-e DE-627 ger DE-627 rakwb eng 610 ASE Li, Guowei verfasserin aut Efficacy of vitamin D supplementation in depression in adults: a systematic review protocol 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The role of vitamin D in management of depression is unclear. Results from observational and emerging randomized controlled trials (RCTs) investigating the efficacy of vitamin D in depression lack consistency - with some suggesting a positive association while others show a negative or inconclusive association. Methods/Design The primary aim of this study is to conduct a systematic review of RCTs to assess the effect of oral vitamin D supplementation versus placebo on depression symptoms measured by scales and the proportion of patients with symptomatic improvement according to the authors’ original definition. Secondary aims include assessing the change in quality of life, adverse events and treatment discontinuation. We will conduct the systematic review and meta-analysis according to the recommendations of the Cochrane Handbook for Systematic Reviews of Interventions. We will search the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (1966 to present), EMBASE (1980 to present), CINAHL (1982 to present), PsychINFO (1967 to present) and ClinicalTrials.gov. Unpublished work will be identified by searching two major conferences: the International Vitamin Conference, the Anxiety Disorders and Depression Conference, while grey literature will be acquired by contacting authors of included studies. We will use the random-effects meta-analysis to synthesize the data by pooling the results of included studies. Discussion The results of this systematic review will be helpful in clarifying the efficacy of vitamin D supplementation and providing evidence to establish guidelines for implementation of vitamin D for depression in general practice and other relevant settings. Study registration Unique identifier: CRD42013003849. Vitamin D (dpeaa)DE-He213 Depression (dpeaa)DE-He213 Randomized controlled trial (dpeaa)DE-He213 Adults (dpeaa)DE-He213 Efficacy (dpeaa)DE-He213 Systematic review protocol (dpeaa)DE-He213 Mbuagbaw, Lawrence verfasserin aut Samaan, Zainab verfasserin aut Zhang, Shiyuan verfasserin aut Adachi, Jonathan D verfasserin aut Papaioannou, Alexandra verfasserin aut Thabane, Lehana verfasserin aut Enthalten in Systematic Reviews London : Biomed Central, 2012 2(2013), 1 vom: 08. Aug. (DE-627)718627210 (DE-600)2662257-9 2046-4053 nnns volume:2 year:2013 number:1 day:08 month:08 https://dx.doi.org/10.1186/2046-4053-2-64 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2013 1 08 08
allfieldsGer	10.1186/2046-4053-2-64 doi (DE-627)SPR032287828 (SPR)2046-4053-2-64-e DE-627 ger DE-627 rakwb eng 610 ASE Li, Guowei verfasserin aut Efficacy of vitamin D supplementation in depression in adults: a systematic review protocol 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The role of vitamin D in management of depression is unclear. Results from observational and emerging randomized controlled trials (RCTs) investigating the efficacy of vitamin D in depression lack consistency - with some suggesting a positive association while others show a negative or inconclusive association. Methods/Design The primary aim of this study is to conduct a systematic review of RCTs to assess the effect of oral vitamin D supplementation versus placebo on depression symptoms measured by scales and the proportion of patients with symptomatic improvement according to the authors’ original definition. Secondary aims include assessing the change in quality of life, adverse events and treatment discontinuation. We will conduct the systematic review and meta-analysis according to the recommendations of the Cochrane Handbook for Systematic Reviews of Interventions. We will search the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (1966 to present), EMBASE (1980 to present), CINAHL (1982 to present), PsychINFO (1967 to present) and ClinicalTrials.gov. Unpublished work will be identified by searching two major conferences: the International Vitamin Conference, the Anxiety Disorders and Depression Conference, while grey literature will be acquired by contacting authors of included studies. We will use the random-effects meta-analysis to synthesize the data by pooling the results of included studies. Discussion The results of this systematic review will be helpful in clarifying the efficacy of vitamin D supplementation and providing evidence to establish guidelines for implementation of vitamin D for depression in general practice and other relevant settings. Study registration Unique identifier: CRD42013003849. Vitamin D (dpeaa)DE-He213 Depression (dpeaa)DE-He213 Randomized controlled trial (dpeaa)DE-He213 Adults (dpeaa)DE-He213 Efficacy (dpeaa)DE-He213 Systematic review protocol (dpeaa)DE-He213 Mbuagbaw, Lawrence verfasserin aut Samaan, Zainab verfasserin aut Zhang, Shiyuan verfasserin aut Adachi, Jonathan D verfasserin aut Papaioannou, Alexandra verfasserin aut Thabane, Lehana verfasserin aut Enthalten in Systematic Reviews London : Biomed Central, 2012 2(2013), 1 vom: 08. Aug. (DE-627)718627210 (DE-600)2662257-9 2046-4053 nnns volume:2 year:2013 number:1 day:08 month:08 https://dx.doi.org/10.1186/2046-4053-2-64 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2013 1 08 08
allfieldsSound	10.1186/2046-4053-2-64 doi (DE-627)SPR032287828 (SPR)2046-4053-2-64-e DE-627 ger DE-627 rakwb eng 610 ASE Li, Guowei verfasserin aut Efficacy of vitamin D supplementation in depression in adults: a systematic review protocol 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The role of vitamin D in management of depression is unclear. Results from observational and emerging randomized controlled trials (RCTs) investigating the efficacy of vitamin D in depression lack consistency - with some suggesting a positive association while others show a negative or inconclusive association. Methods/Design The primary aim of this study is to conduct a systematic review of RCTs to assess the effect of oral vitamin D supplementation versus placebo on depression symptoms measured by scales and the proportion of patients with symptomatic improvement according to the authors’ original definition. Secondary aims include assessing the change in quality of life, adverse events and treatment discontinuation. We will conduct the systematic review and meta-analysis according to the recommendations of the Cochrane Handbook for Systematic Reviews of Interventions. We will search the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (1966 to present), EMBASE (1980 to present), CINAHL (1982 to present), PsychINFO (1967 to present) and ClinicalTrials.gov. Unpublished work will be identified by searching two major conferences: the International Vitamin Conference, the Anxiety Disorders and Depression Conference, while grey literature will be acquired by contacting authors of included studies. We will use the random-effects meta-analysis to synthesize the data by pooling the results of included studies. Discussion The results of this systematic review will be helpful in clarifying the efficacy of vitamin D supplementation and providing evidence to establish guidelines for implementation of vitamin D for depression in general practice and other relevant settings. Study registration Unique identifier: CRD42013003849. Vitamin D (dpeaa)DE-He213 Depression (dpeaa)DE-He213 Randomized controlled trial (dpeaa)DE-He213 Adults (dpeaa)DE-He213 Efficacy (dpeaa)DE-He213 Systematic review protocol (dpeaa)DE-He213 Mbuagbaw, Lawrence verfasserin aut Samaan, Zainab verfasserin aut Zhang, Shiyuan verfasserin aut Adachi, Jonathan D verfasserin aut Papaioannou, Alexandra verfasserin aut Thabane, Lehana verfasserin aut Enthalten in Systematic Reviews London : Biomed Central, 2012 2(2013), 1 vom: 08. Aug. (DE-627)718627210 (DE-600)2662257-9 2046-4053 nnns volume:2 year:2013 number:1 day:08 month:08 https://dx.doi.org/10.1186/2046-4053-2-64 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2013 1 08 08
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author	Li, Guowei
spellingShingle	Li, Guowei ddc 610 misc Vitamin D misc Depression misc Randomized controlled trial misc Adults misc Efficacy misc Systematic review protocol Efficacy of vitamin D supplementation in depression in adults: a systematic review protocol
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topic_title	610 ASE Efficacy of vitamin D supplementation in depression in adults: a systematic review protocol Vitamin D (dpeaa)DE-He213 Depression (dpeaa)DE-He213 Randomized controlled trial (dpeaa)DE-He213 Adults (dpeaa)DE-He213 Efficacy (dpeaa)DE-He213 Systematic review protocol (dpeaa)DE-He213
topic	ddc 610 misc Vitamin D misc Depression misc Randomized controlled trial misc Adults misc Efficacy misc Systematic review protocol
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title	Efficacy of vitamin D supplementation in depression in adults: a systematic review protocol
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title_full	Efficacy of vitamin D supplementation in depression in adults: a systematic review protocol
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author_browse	Li, Guowei Mbuagbaw, Lawrence Samaan, Zainab Zhang, Shiyuan Adachi, Jonathan D Papaioannou, Alexandra Thabane, Lehana
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title_sort	efficacy of vitamin d supplementation in depression in adults: a systematic review protocol
title_auth	Efficacy of vitamin D supplementation in depression in adults: a systematic review protocol
abstract	Background The role of vitamin D in management of depression is unclear. Results from observational and emerging randomized controlled trials (RCTs) investigating the efficacy of vitamin D in depression lack consistency - with some suggesting a positive association while others show a negative or inconclusive association. Methods/Design The primary aim of this study is to conduct a systematic review of RCTs to assess the effect of oral vitamin D supplementation versus placebo on depression symptoms measured by scales and the proportion of patients with symptomatic improvement according to the authors’ original definition. Secondary aims include assessing the change in quality of life, adverse events and treatment discontinuation. We will conduct the systematic review and meta-analysis according to the recommendations of the Cochrane Handbook for Systematic Reviews of Interventions. We will search the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (1966 to present), EMBASE (1980 to present), CINAHL (1982 to present), PsychINFO (1967 to present) and ClinicalTrials.gov. Unpublished work will be identified by searching two major conferences: the International Vitamin Conference, the Anxiety Disorders and Depression Conference, while grey literature will be acquired by contacting authors of included studies. We will use the random-effects meta-analysis to synthesize the data by pooling the results of included studies. Discussion The results of this systematic review will be helpful in clarifying the efficacy of vitamin D supplementation and providing evidence to establish guidelines for implementation of vitamin D for depression in general practice and other relevant settings. Study registration Unique identifier: CRD42013003849.
abstractGer	Background The role of vitamin D in management of depression is unclear. Results from observational and emerging randomized controlled trials (RCTs) investigating the efficacy of vitamin D in depression lack consistency - with some suggesting a positive association while others show a negative or inconclusive association. Methods/Design The primary aim of this study is to conduct a systematic review of RCTs to assess the effect of oral vitamin D supplementation versus placebo on depression symptoms measured by scales and the proportion of patients with symptomatic improvement according to the authors’ original definition. Secondary aims include assessing the change in quality of life, adverse events and treatment discontinuation. We will conduct the systematic review and meta-analysis according to the recommendations of the Cochrane Handbook for Systematic Reviews of Interventions. We will search the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (1966 to present), EMBASE (1980 to present), CINAHL (1982 to present), PsychINFO (1967 to present) and ClinicalTrials.gov. Unpublished work will be identified by searching two major conferences: the International Vitamin Conference, the Anxiety Disorders and Depression Conference, while grey literature will be acquired by contacting authors of included studies. We will use the random-effects meta-analysis to synthesize the data by pooling the results of included studies. Discussion The results of this systematic review will be helpful in clarifying the efficacy of vitamin D supplementation and providing evidence to establish guidelines for implementation of vitamin D for depression in general practice and other relevant settings. Study registration Unique identifier: CRD42013003849.
abstract_unstemmed	Background The role of vitamin D in management of depression is unclear. Results from observational and emerging randomized controlled trials (RCTs) investigating the efficacy of vitamin D in depression lack consistency - with some suggesting a positive association while others show a negative or inconclusive association. Methods/Design The primary aim of this study is to conduct a systematic review of RCTs to assess the effect of oral vitamin D supplementation versus placebo on depression symptoms measured by scales and the proportion of patients with symptomatic improvement according to the authors’ original definition. Secondary aims include assessing the change in quality of life, adverse events and treatment discontinuation. We will conduct the systematic review and meta-analysis according to the recommendations of the Cochrane Handbook for Systematic Reviews of Interventions. We will search the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (1966 to present), EMBASE (1980 to present), CINAHL (1982 to present), PsychINFO (1967 to present) and ClinicalTrials.gov. Unpublished work will be identified by searching two major conferences: the International Vitamin Conference, the Anxiety Disorders and Depression Conference, while grey literature will be acquired by contacting authors of included studies. We will use the random-effects meta-analysis to synthesize the data by pooling the results of included studies. Discussion The results of this systematic review will be helpful in clarifying the efficacy of vitamin D supplementation and providing evidence to establish guidelines for implementation of vitamin D for depression in general practice and other relevant settings. Study registration Unique identifier: CRD42013003849.
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title_short	Efficacy of vitamin D supplementation in depression in adults: a systematic review protocol
url	https://dx.doi.org/10.1186/2046-4053-2-64
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author2	Mbuagbaw, Lawrence Samaan, Zainab Zhang, Shiyuan Adachi, Jonathan D Papaioannou, Alexandra Thabane, Lehana
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We will search the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (1966 to present), EMBASE (1980 to present), CINAHL (1982 to present), PsychINFO (1967 to present) and ClinicalTrials.gov. Unpublished work will be identified by searching two major conferences: the International Vitamin Conference, the Anxiety Disorders and Depression Conference, while grey literature will be acquired by contacting authors of included studies. We will use the random-effects meta-analysis to synthesize the data by pooling the results of included studies. Discussion The results of this systematic review will be helpful in clarifying the efficacy of vitamin D supplementation and providing evidence to establish guidelines for implementation of vitamin D for depression in general practice and other relevant settings. 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Efficacy of vitamin D supplementation in depression in adults: a systematic review protocol

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