Cancer risk in HIV-infected individuals on HAART is largely attributed to oncogenic infections and state of immunocompetence

Objectives To estimate the cancer risk of HIV-infected patients in the HAART era with respect to a general reference population and to determine risk factors for malignancy. Methods Long term (1996-2009) cancer incidence of the Bonn single centre HIV cohort was compared to the incidence of the refer...
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Autor*in:	Vogel, M [verfasserIn] Friedrich, O [verfasserIn] Lüchters, G [verfasserIn] Holleczek, B [verfasserIn] Wasmuth, JC [verfasserIn] Anadol, E [verfasserIn] Schwarze-Zander, C [verfasserIn] Nattermann, J [verfasserIn] Oldenburg, J [verfasserIn] Sauerbruch, T [verfasserIn] Rockstroh, JK [verfasserIn] Spengler, U [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2011

Schlagwörter:	Lymphoma Carcinoma HIV CD4-T cells HAART

Übergeordnetes Werk:	Enthalten in: European journal of medical research - London : BioMed Central, 2000, 16(2011), 3 vom: 28. März
Übergeordnetes Werk:	volume:16 ; year:2011 ; number:3 ; day:28 ; month:03

Links:	Volltext

DOI / URN:	10.1186/2047-783X-16-3-101

Katalog-ID:	SPR03259299X

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520			\|a Objectives To estimate the cancer risk of HIV-infected patients in the HAART era with respect to a general reference population and to determine risk factors for malignancy. Methods Long term (1996-2009) cancer incidence of the Bonn single centre HIV cohort was compared to the incidence of the reference population of Saarland using standardized incidence ratios (SIR). Poisson regression analysis was used to identify predictors of cancer risk. Results 1,476 patients entered the cohort, enabling 8,772 person years of observation. 121 tumours in 114 patients, 7 in-situ and 114 invasive cancers, were identified. Malignancies associated with infectious agents such as Kaposi sarcoma (SIRs: male: 5,683; female: 277), non-Hodgkin lymphoma (SIRs male: 35; female: 18), anal cancer (SIRs male: 88; female: 115) as well a cervical carcinoma (SIR female: 4) and Hodgkin's disease (SIR male: 39) and liver cancer (SIR male: 18) were substantially more frequent in HIV-infected patients than in the general population (p < 0.001, each), whereas all other types of cancer were not increased. Poisson regression identified HAART (incidence rate ratio IRR (95% CI): 0.28 (0.19-0.41), p < 0.001), CD4 count (IRR per 100 cells/μl increase: 0.66 (0.57-0.76), p < 0.001), hepatitis B (IRR: 2.15 (1.10-4.20), p = 0.046) and age (IRR per 10 year increase: 1.23 (1.03 - 1.46), p = 0.023) as independent predictors for the occurrence of any type of cancer. Conclusions HAART and preserved CD4 cells preferentially reduce the risk of malignancies associated with oncogenic infections.
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700	1		\|a Sauerbruch, T \|e verfasserin \|4 aut
700	1		\|a Rockstroh, JK \|e verfasserin \|4 aut
700	1		\|a Spengler, U \|e verfasserin \|4 aut
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allfields	10.1186/2047-783X-16-3-101 doi (DE-627)SPR03259299X (SPR)2047-783X-16-3-101-e DE-627 ger DE-627 rakwb eng 610 ASE Vogel, M verfasserin aut Cancer risk in HIV-infected individuals on HAART is largely attributed to oncogenic infections and state of immunocompetence 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives To estimate the cancer risk of HIV-infected patients in the HAART era with respect to a general reference population and to determine risk factors for malignancy. Methods Long term (1996-2009) cancer incidence of the Bonn single centre HIV cohort was compared to the incidence of the reference population of Saarland using standardized incidence ratios (SIR). Poisson regression analysis was used to identify predictors of cancer risk. Results 1,476 patients entered the cohort, enabling 8,772 person years of observation. 121 tumours in 114 patients, 7 in-situ and 114 invasive cancers, were identified. Malignancies associated with infectious agents such as Kaposi sarcoma (SIRs: male: 5,683; female: 277), non-Hodgkin lymphoma (SIRs male: 35; female: 18), anal cancer (SIRs male: 88; female: 115) as well a cervical carcinoma (SIR female: 4) and Hodgkin's disease (SIR male: 39) and liver cancer (SIR male: 18) were substantially more frequent in HIV-infected patients than in the general population (p < 0.001, each), whereas all other types of cancer were not increased. Poisson regression identified HAART (incidence rate ratio IRR (95% CI): 0.28 (0.19-0.41), p < 0.001), CD4 count (IRR per 100 cells/μl increase: 0.66 (0.57-0.76), p < 0.001), hepatitis B (IRR: 2.15 (1.10-4.20), p = 0.046) and age (IRR per 10 year increase: 1.23 (1.03 - 1.46), p = 0.023) as independent predictors for the occurrence of any type of cancer. Conclusions HAART and preserved CD4 cells preferentially reduce the risk of malignancies associated with oncogenic infections. Lymphoma (dpeaa)DE-He213 Carcinoma (dpeaa)DE-He213 HIV (dpeaa)DE-He213 CD4-T cells (dpeaa)DE-He213 HAART (dpeaa)DE-He213 Friedrich, O verfasserin aut Lüchters, G verfasserin aut Holleczek, B verfasserin aut Wasmuth, JC verfasserin aut Anadol, E verfasserin aut Schwarze-Zander, C verfasserin aut Nattermann, J verfasserin aut Oldenburg, J verfasserin aut Sauerbruch, T verfasserin aut Rockstroh, JK verfasserin aut Spengler, U verfasserin aut Enthalten in European journal of medical research London : BioMed Central, 2000 16(2011), 3 vom: 28. März (DE-627)375977775 (DE-600)2129989-4 2047-783X nnns volume:16 year:2011 number:3 day:28 month:03 https://dx.doi.org/10.1186/2047-783X-16-3-101 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2011 3 28 03
spelling	10.1186/2047-783X-16-3-101 doi (DE-627)SPR03259299X (SPR)2047-783X-16-3-101-e DE-627 ger DE-627 rakwb eng 610 ASE Vogel, M verfasserin aut Cancer risk in HIV-infected individuals on HAART is largely attributed to oncogenic infections and state of immunocompetence 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives To estimate the cancer risk of HIV-infected patients in the HAART era with respect to a general reference population and to determine risk factors for malignancy. Methods Long term (1996-2009) cancer incidence of the Bonn single centre HIV cohort was compared to the incidence of the reference population of Saarland using standardized incidence ratios (SIR). Poisson regression analysis was used to identify predictors of cancer risk. Results 1,476 patients entered the cohort, enabling 8,772 person years of observation. 121 tumours in 114 patients, 7 in-situ and 114 invasive cancers, were identified. Malignancies associated with infectious agents such as Kaposi sarcoma (SIRs: male: 5,683; female: 277), non-Hodgkin lymphoma (SIRs male: 35; female: 18), anal cancer (SIRs male: 88; female: 115) as well a cervical carcinoma (SIR female: 4) and Hodgkin's disease (SIR male: 39) and liver cancer (SIR male: 18) were substantially more frequent in HIV-infected patients than in the general population (p < 0.001, each), whereas all other types of cancer were not increased. Poisson regression identified HAART (incidence rate ratio IRR (95% CI): 0.28 (0.19-0.41), p < 0.001), CD4 count (IRR per 100 cells/μl increase: 0.66 (0.57-0.76), p < 0.001), hepatitis B (IRR: 2.15 (1.10-4.20), p = 0.046) and age (IRR per 10 year increase: 1.23 (1.03 - 1.46), p = 0.023) as independent predictors for the occurrence of any type of cancer. Conclusions HAART and preserved CD4 cells preferentially reduce the risk of malignancies associated with oncogenic infections. Lymphoma (dpeaa)DE-He213 Carcinoma (dpeaa)DE-He213 HIV (dpeaa)DE-He213 CD4-T cells (dpeaa)DE-He213 HAART (dpeaa)DE-He213 Friedrich, O verfasserin aut Lüchters, G verfasserin aut Holleczek, B verfasserin aut Wasmuth, JC verfasserin aut Anadol, E verfasserin aut Schwarze-Zander, C verfasserin aut Nattermann, J verfasserin aut Oldenburg, J verfasserin aut Sauerbruch, T verfasserin aut Rockstroh, JK verfasserin aut Spengler, U verfasserin aut Enthalten in European journal of medical research London : BioMed Central, 2000 16(2011), 3 vom: 28. März (DE-627)375977775 (DE-600)2129989-4 2047-783X nnns volume:16 year:2011 number:3 day:28 month:03 https://dx.doi.org/10.1186/2047-783X-16-3-101 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2011 3 28 03
allfields_unstemmed	10.1186/2047-783X-16-3-101 doi (DE-627)SPR03259299X (SPR)2047-783X-16-3-101-e DE-627 ger DE-627 rakwb eng 610 ASE Vogel, M verfasserin aut Cancer risk in HIV-infected individuals on HAART is largely attributed to oncogenic infections and state of immunocompetence 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives To estimate the cancer risk of HIV-infected patients in the HAART era with respect to a general reference population and to determine risk factors for malignancy. Methods Long term (1996-2009) cancer incidence of the Bonn single centre HIV cohort was compared to the incidence of the reference population of Saarland using standardized incidence ratios (SIR). Poisson regression analysis was used to identify predictors of cancer risk. Results 1,476 patients entered the cohort, enabling 8,772 person years of observation. 121 tumours in 114 patients, 7 in-situ and 114 invasive cancers, were identified. Malignancies associated with infectious agents such as Kaposi sarcoma (SIRs: male: 5,683; female: 277), non-Hodgkin lymphoma (SIRs male: 35; female: 18), anal cancer (SIRs male: 88; female: 115) as well a cervical carcinoma (SIR female: 4) and Hodgkin's disease (SIR male: 39) and liver cancer (SIR male: 18) were substantially more frequent in HIV-infected patients than in the general population (p < 0.001, each), whereas all other types of cancer were not increased. Poisson regression identified HAART (incidence rate ratio IRR (95% CI): 0.28 (0.19-0.41), p < 0.001), CD4 count (IRR per 100 cells/μl increase: 0.66 (0.57-0.76), p < 0.001), hepatitis B (IRR: 2.15 (1.10-4.20), p = 0.046) and age (IRR per 10 year increase: 1.23 (1.03 - 1.46), p = 0.023) as independent predictors for the occurrence of any type of cancer. Conclusions HAART and preserved CD4 cells preferentially reduce the risk of malignancies associated with oncogenic infections. Lymphoma (dpeaa)DE-He213 Carcinoma (dpeaa)DE-He213 HIV (dpeaa)DE-He213 CD4-T cells (dpeaa)DE-He213 HAART (dpeaa)DE-He213 Friedrich, O verfasserin aut Lüchters, G verfasserin aut Holleczek, B verfasserin aut Wasmuth, JC verfasserin aut Anadol, E verfasserin aut Schwarze-Zander, C verfasserin aut Nattermann, J verfasserin aut Oldenburg, J verfasserin aut Sauerbruch, T verfasserin aut Rockstroh, JK verfasserin aut Spengler, U verfasserin aut Enthalten in European journal of medical research London : BioMed Central, 2000 16(2011), 3 vom: 28. März (DE-627)375977775 (DE-600)2129989-4 2047-783X nnns volume:16 year:2011 number:3 day:28 month:03 https://dx.doi.org/10.1186/2047-783X-16-3-101 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2011 3 28 03
allfieldsGer	10.1186/2047-783X-16-3-101 doi (DE-627)SPR03259299X (SPR)2047-783X-16-3-101-e DE-627 ger DE-627 rakwb eng 610 ASE Vogel, M verfasserin aut Cancer risk in HIV-infected individuals on HAART is largely attributed to oncogenic infections and state of immunocompetence 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives To estimate the cancer risk of HIV-infected patients in the HAART era with respect to a general reference population and to determine risk factors for malignancy. Methods Long term (1996-2009) cancer incidence of the Bonn single centre HIV cohort was compared to the incidence of the reference population of Saarland using standardized incidence ratios (SIR). Poisson regression analysis was used to identify predictors of cancer risk. Results 1,476 patients entered the cohort, enabling 8,772 person years of observation. 121 tumours in 114 patients, 7 in-situ and 114 invasive cancers, were identified. Malignancies associated with infectious agents such as Kaposi sarcoma (SIRs: male: 5,683; female: 277), non-Hodgkin lymphoma (SIRs male: 35; female: 18), anal cancer (SIRs male: 88; female: 115) as well a cervical carcinoma (SIR female: 4) and Hodgkin's disease (SIR male: 39) and liver cancer (SIR male: 18) were substantially more frequent in HIV-infected patients than in the general population (p < 0.001, each), whereas all other types of cancer were not increased. Poisson regression identified HAART (incidence rate ratio IRR (95% CI): 0.28 (0.19-0.41), p < 0.001), CD4 count (IRR per 100 cells/μl increase: 0.66 (0.57-0.76), p < 0.001), hepatitis B (IRR: 2.15 (1.10-4.20), p = 0.046) and age (IRR per 10 year increase: 1.23 (1.03 - 1.46), p = 0.023) as independent predictors for the occurrence of any type of cancer. Conclusions HAART and preserved CD4 cells preferentially reduce the risk of malignancies associated with oncogenic infections. Lymphoma (dpeaa)DE-He213 Carcinoma (dpeaa)DE-He213 HIV (dpeaa)DE-He213 CD4-T cells (dpeaa)DE-He213 HAART (dpeaa)DE-He213 Friedrich, O verfasserin aut Lüchters, G verfasserin aut Holleczek, B verfasserin aut Wasmuth, JC verfasserin aut Anadol, E verfasserin aut Schwarze-Zander, C verfasserin aut Nattermann, J verfasserin aut Oldenburg, J verfasserin aut Sauerbruch, T verfasserin aut Rockstroh, JK verfasserin aut Spengler, U verfasserin aut Enthalten in European journal of medical research London : BioMed Central, 2000 16(2011), 3 vom: 28. März (DE-627)375977775 (DE-600)2129989-4 2047-783X nnns volume:16 year:2011 number:3 day:28 month:03 https://dx.doi.org/10.1186/2047-783X-16-3-101 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2011 3 28 03
allfieldsSound	10.1186/2047-783X-16-3-101 doi (DE-627)SPR03259299X (SPR)2047-783X-16-3-101-e DE-627 ger DE-627 rakwb eng 610 ASE Vogel, M verfasserin aut Cancer risk in HIV-infected individuals on HAART is largely attributed to oncogenic infections and state of immunocompetence 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives To estimate the cancer risk of HIV-infected patients in the HAART era with respect to a general reference population and to determine risk factors for malignancy. Methods Long term (1996-2009) cancer incidence of the Bonn single centre HIV cohort was compared to the incidence of the reference population of Saarland using standardized incidence ratios (SIR). Poisson regression analysis was used to identify predictors of cancer risk. Results 1,476 patients entered the cohort, enabling 8,772 person years of observation. 121 tumours in 114 patients, 7 in-situ and 114 invasive cancers, were identified. Malignancies associated with infectious agents such as Kaposi sarcoma (SIRs: male: 5,683; female: 277), non-Hodgkin lymphoma (SIRs male: 35; female: 18), anal cancer (SIRs male: 88; female: 115) as well a cervical carcinoma (SIR female: 4) and Hodgkin's disease (SIR male: 39) and liver cancer (SIR male: 18) were substantially more frequent in HIV-infected patients than in the general population (p < 0.001, each), whereas all other types of cancer were not increased. Poisson regression identified HAART (incidence rate ratio IRR (95% CI): 0.28 (0.19-0.41), p < 0.001), CD4 count (IRR per 100 cells/μl increase: 0.66 (0.57-0.76), p < 0.001), hepatitis B (IRR: 2.15 (1.10-4.20), p = 0.046) and age (IRR per 10 year increase: 1.23 (1.03 - 1.46), p = 0.023) as independent predictors for the occurrence of any type of cancer. Conclusions HAART and preserved CD4 cells preferentially reduce the risk of malignancies associated with oncogenic infections. Lymphoma (dpeaa)DE-He213 Carcinoma (dpeaa)DE-He213 HIV (dpeaa)DE-He213 CD4-T cells (dpeaa)DE-He213 HAART (dpeaa)DE-He213 Friedrich, O verfasserin aut Lüchters, G verfasserin aut Holleczek, B verfasserin aut Wasmuth, JC verfasserin aut Anadol, E verfasserin aut Schwarze-Zander, C verfasserin aut Nattermann, J verfasserin aut Oldenburg, J verfasserin aut Sauerbruch, T verfasserin aut Rockstroh, JK verfasserin aut Spengler, U verfasserin aut Enthalten in European journal of medical research London : BioMed Central, 2000 16(2011), 3 vom: 28. März (DE-627)375977775 (DE-600)2129989-4 2047-783X nnns volume:16 year:2011 number:3 day:28 month:03 https://dx.doi.org/10.1186/2047-783X-16-3-101 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2011 3 28 03
language	English
source	Enthalten in European journal of medical research 16(2011), 3 vom: 28. März volume:16 year:2011 number:3 day:28 month:03
sourceStr	Enthalten in European journal of medical research 16(2011), 3 vom: 28. März volume:16 year:2011 number:3 day:28 month:03
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Lymphoma Carcinoma HIV CD4-T cells HAART
dewey-raw	610
isfreeaccess_bool	false
container_title	European journal of medical research
authorswithroles_txt_mv	Vogel, M @@aut@@ Friedrich, O @@aut@@ Lüchters, G @@aut@@ Holleczek, B @@aut@@ Wasmuth, JC @@aut@@ Anadol, E @@aut@@ Schwarze-Zander, C @@aut@@ Nattermann, J @@aut@@ Oldenburg, J @@aut@@ Sauerbruch, T @@aut@@ Rockstroh, JK @@aut@@ Spengler, U @@aut@@
publishDateDaySort_date	2011-03-28T00:00:00Z
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author	Vogel, M
spellingShingle	Vogel, M ddc 610 misc Lymphoma misc Carcinoma misc HIV misc CD4-T cells misc HAART Cancer risk in HIV-infected individuals on HAART is largely attributed to oncogenic infections and state of immunocompetence
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topic_title	610 ASE Cancer risk in HIV-infected individuals on HAART is largely attributed to oncogenic infections and state of immunocompetence Lymphoma (dpeaa)DE-He213 Carcinoma (dpeaa)DE-He213 HIV (dpeaa)DE-He213 CD4-T cells (dpeaa)DE-He213 HAART (dpeaa)DE-He213
topic	ddc 610 misc Lymphoma misc Carcinoma misc HIV misc CD4-T cells misc HAART
topic_unstemmed	ddc 610 misc Lymphoma misc Carcinoma misc HIV misc CD4-T cells misc HAART
topic_browse	ddc 610 misc Lymphoma misc Carcinoma misc HIV misc CD4-T cells misc HAART
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title	Cancer risk in HIV-infected individuals on HAART is largely attributed to oncogenic infections and state of immunocompetence
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title_full	Cancer risk in HIV-infected individuals on HAART is largely attributed to oncogenic infections and state of immunocompetence
author_sort	Vogel, M
journal	European journal of medical research
journalStr	European journal of medical research
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author_browse	Vogel, M Friedrich, O Lüchters, G Holleczek, B Wasmuth, JC Anadol, E Schwarze-Zander, C Nattermann, J Oldenburg, J Sauerbruch, T Rockstroh, JK Spengler, U
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author-letter	Vogel, M
doi_str_mv	10.1186/2047-783X-16-3-101
dewey-full	610
author2-role	verfasserin
title_sort	cancer risk in hiv-infected individuals on haart is largely attributed to oncogenic infections and state of immunocompetence
title_auth	Cancer risk in HIV-infected individuals on HAART is largely attributed to oncogenic infections and state of immunocompetence
abstract	Objectives To estimate the cancer risk of HIV-infected patients in the HAART era with respect to a general reference population and to determine risk factors for malignancy. Methods Long term (1996-2009) cancer incidence of the Bonn single centre HIV cohort was compared to the incidence of the reference population of Saarland using standardized incidence ratios (SIR). Poisson regression analysis was used to identify predictors of cancer risk. Results 1,476 patients entered the cohort, enabling 8,772 person years of observation. 121 tumours in 114 patients, 7 in-situ and 114 invasive cancers, were identified. Malignancies associated with infectious agents such as Kaposi sarcoma (SIRs: male: 5,683; female: 277), non-Hodgkin lymphoma (SIRs male: 35; female: 18), anal cancer (SIRs male: 88; female: 115) as well a cervical carcinoma (SIR female: 4) and Hodgkin's disease (SIR male: 39) and liver cancer (SIR male: 18) were substantially more frequent in HIV-infected patients than in the general population (p < 0.001, each), whereas all other types of cancer were not increased. Poisson regression identified HAART (incidence rate ratio IRR (95% CI): 0.28 (0.19-0.41), p < 0.001), CD4 count (IRR per 100 cells/μl increase: 0.66 (0.57-0.76), p < 0.001), hepatitis B (IRR: 2.15 (1.10-4.20), p = 0.046) and age (IRR per 10 year increase: 1.23 (1.03 - 1.46), p = 0.023) as independent predictors for the occurrence of any type of cancer. Conclusions HAART and preserved CD4 cells preferentially reduce the risk of malignancies associated with oncogenic infections.
abstractGer	Objectives To estimate the cancer risk of HIV-infected patients in the HAART era with respect to a general reference population and to determine risk factors for malignancy. Methods Long term (1996-2009) cancer incidence of the Bonn single centre HIV cohort was compared to the incidence of the reference population of Saarland using standardized incidence ratios (SIR). Poisson regression analysis was used to identify predictors of cancer risk. Results 1,476 patients entered the cohort, enabling 8,772 person years of observation. 121 tumours in 114 patients, 7 in-situ and 114 invasive cancers, were identified. Malignancies associated with infectious agents such as Kaposi sarcoma (SIRs: male: 5,683; female: 277), non-Hodgkin lymphoma (SIRs male: 35; female: 18), anal cancer (SIRs male: 88; female: 115) as well a cervical carcinoma (SIR female: 4) and Hodgkin's disease (SIR male: 39) and liver cancer (SIR male: 18) were substantially more frequent in HIV-infected patients than in the general population (p < 0.001, each), whereas all other types of cancer were not increased. Poisson regression identified HAART (incidence rate ratio IRR (95% CI): 0.28 (0.19-0.41), p < 0.001), CD4 count (IRR per 100 cells/μl increase: 0.66 (0.57-0.76), p < 0.001), hepatitis B (IRR: 2.15 (1.10-4.20), p = 0.046) and age (IRR per 10 year increase: 1.23 (1.03 - 1.46), p = 0.023) as independent predictors for the occurrence of any type of cancer. Conclusions HAART and preserved CD4 cells preferentially reduce the risk of malignancies associated with oncogenic infections.
abstract_unstemmed	Objectives To estimate the cancer risk of HIV-infected patients in the HAART era with respect to a general reference population and to determine risk factors for malignancy. Methods Long term (1996-2009) cancer incidence of the Bonn single centre HIV cohort was compared to the incidence of the reference population of Saarland using standardized incidence ratios (SIR). Poisson regression analysis was used to identify predictors of cancer risk. Results 1,476 patients entered the cohort, enabling 8,772 person years of observation. 121 tumours in 114 patients, 7 in-situ and 114 invasive cancers, were identified. Malignancies associated with infectious agents such as Kaposi sarcoma (SIRs: male: 5,683; female: 277), non-Hodgkin lymphoma (SIRs male: 35; female: 18), anal cancer (SIRs male: 88; female: 115) as well a cervical carcinoma (SIR female: 4) and Hodgkin's disease (SIR male: 39) and liver cancer (SIR male: 18) were substantially more frequent in HIV-infected patients than in the general population (p < 0.001, each), whereas all other types of cancer were not increased. Poisson regression identified HAART (incidence rate ratio IRR (95% CI): 0.28 (0.19-0.41), p < 0.001), CD4 count (IRR per 100 cells/μl increase: 0.66 (0.57-0.76), p < 0.001), hepatitis B (IRR: 2.15 (1.10-4.20), p = 0.046) and age (IRR per 10 year increase: 1.23 (1.03 - 1.46), p = 0.023) as independent predictors for the occurrence of any type of cancer. Conclusions HAART and preserved CD4 cells preferentially reduce the risk of malignancies associated with oncogenic infections.
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container_issue	3
title_short	Cancer risk in HIV-infected individuals on HAART is largely attributed to oncogenic infections and state of immunocompetence
url	https://dx.doi.org/10.1186/2047-783X-16-3-101
remote_bool	true
author2	Friedrich, O Lüchters, G Holleczek, B Wasmuth, JC Anadol, E Schwarze-Zander, C Nattermann, J Oldenburg, J Sauerbruch, T Rockstroh, JK Spengler, U
author2Str	Friedrich, O Lüchters, G Holleczek, B Wasmuth, JC Anadol, E Schwarze-Zander, C Nattermann, J Oldenburg, J Sauerbruch, T Rockstroh, JK Spengler, U
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up_date	2024-07-03T13:43:20.455Z
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