Involvement of free radicals in breast cancer

Abstract Researchers have recently shown an increased interest in free radicals and their role in the tumor microenvironment. Free radicals are molecules with high instability and reactivity due to the presence of an odd number of electrons in the outermost orbit of their atoms. Free radicals includ...
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Gespeichert in:

Autor*in:	Ríos-Arrabal, Sandra [verfasserIn] Artacho-Cordón, Francisco [verfasserIn] León, Josefa [verfasserIn] Román-Marinetto, Elisa [verfasserIn] del Mar Salinas-Asensio, María [verfasserIn] Calvente, Irene [verfasserIn] Núñez, Maria Isabel [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	Reactive Oxygen Species Free Radical Reactive Oxygen Species Production Reactive Nitrogen Species Total Antioxidant State

Übergeordnetes Werk:	Enthalten in: SpringerPlus - London : Biomed Central, 2012, 2(2013), 1 vom: 27. Aug.
Übergeordnetes Werk:	volume:2 ; year:2013 ; number:1 ; day:27 ; month:08

Links:	Volltext

DOI / URN:	10.1186/2193-1801-2-404

Katalog-ID:	SPR032751451

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allfields	10.1186/2193-1801-2-404 doi (DE-627)SPR032751451 (SPR)2193-1801-2-404-e DE-627 ger DE-627 rakwb eng 600 ASE Ríos-Arrabal, Sandra verfasserin aut Involvement of free radicals in breast cancer 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Researchers have recently shown an increased interest in free radicals and their role in the tumor microenvironment. Free radicals are molecules with high instability and reactivity due to the presence of an odd number of electrons in the outermost orbit of their atoms. Free radicals include reactive oxygen and nitrogen species, which are key players in the initiation and progression of tumor cells and enhance their metastatic potential. In fact, they are now considered a hallmark of cancer. However, both reactive species may contribute to improve the outcomes of radiotherapy in cancer patients. Besides, high levels of reactive oxygen species may be indicators of genotoxic damage in non-irradiated normal tissues. The purpose of this article is to review recent research on free radicals and carcinogenesis in order to understand the pathways that contribute to tumor malignancy. This review outlines the involvement of free radicals in relevant cellular events, including their effects on genetic instability through (growth factors and tumor suppressor genes, their enhancement of mitogenic signals, and their participation in cell remodeling, proliferation, senescence, apoptosis, and autophagy processes; the possible relationship between free radicals and inflammation is also explored. This knowledge is crucial for evaluating the relevance of free radicals as therapeutic targets in cancer. Reactive Oxygen Species (dpeaa)DE-He213 Free Radical (dpeaa)DE-He213 Reactive Oxygen Species Production (dpeaa)DE-He213 Reactive Nitrogen Species (dpeaa)DE-He213 Total Antioxidant State (dpeaa)DE-He213 Artacho-Cordón, Francisco verfasserin aut León, Josefa verfasserin aut Román-Marinetto, Elisa verfasserin aut del Mar Salinas-Asensio, María verfasserin aut Calvente, Irene verfasserin aut Núñez, Maria Isabel verfasserin aut Enthalten in SpringerPlus London : Biomed Central, 2012 2(2013), 1 vom: 27. Aug. (DE-627)718615298 (DE-600)2661116-8 2193-1801 nnns volume:2 year:2013 number:1 day:27 month:08 https://dx.doi.org/10.1186/2193-1801-2-404 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2013 1 27 08
spelling	10.1186/2193-1801-2-404 doi (DE-627)SPR032751451 (SPR)2193-1801-2-404-e DE-627 ger DE-627 rakwb eng 600 ASE Ríos-Arrabal, Sandra verfasserin aut Involvement of free radicals in breast cancer 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Researchers have recently shown an increased interest in free radicals and their role in the tumor microenvironment. Free radicals are molecules with high instability and reactivity due to the presence of an odd number of electrons in the outermost orbit of their atoms. Free radicals include reactive oxygen and nitrogen species, which are key players in the initiation and progression of tumor cells and enhance their metastatic potential. In fact, they are now considered a hallmark of cancer. However, both reactive species may contribute to improve the outcomes of radiotherapy in cancer patients. Besides, high levels of reactive oxygen species may be indicators of genotoxic damage in non-irradiated normal tissues. The purpose of this article is to review recent research on free radicals and carcinogenesis in order to understand the pathways that contribute to tumor malignancy. This review outlines the involvement of free radicals in relevant cellular events, including their effects on genetic instability through (growth factors and tumor suppressor genes, their enhancement of mitogenic signals, and their participation in cell remodeling, proliferation, senescence, apoptosis, and autophagy processes; the possible relationship between free radicals and inflammation is also explored. This knowledge is crucial for evaluating the relevance of free radicals as therapeutic targets in cancer. Reactive Oxygen Species (dpeaa)DE-He213 Free Radical (dpeaa)DE-He213 Reactive Oxygen Species Production (dpeaa)DE-He213 Reactive Nitrogen Species (dpeaa)DE-He213 Total Antioxidant State (dpeaa)DE-He213 Artacho-Cordón, Francisco verfasserin aut León, Josefa verfasserin aut Román-Marinetto, Elisa verfasserin aut del Mar Salinas-Asensio, María verfasserin aut Calvente, Irene verfasserin aut Núñez, Maria Isabel verfasserin aut Enthalten in SpringerPlus London : Biomed Central, 2012 2(2013), 1 vom: 27. Aug. (DE-627)718615298 (DE-600)2661116-8 2193-1801 nnns volume:2 year:2013 number:1 day:27 month:08 https://dx.doi.org/10.1186/2193-1801-2-404 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2013 1 27 08
allfields_unstemmed	10.1186/2193-1801-2-404 doi (DE-627)SPR032751451 (SPR)2193-1801-2-404-e DE-627 ger DE-627 rakwb eng 600 ASE Ríos-Arrabal, Sandra verfasserin aut Involvement of free radicals in breast cancer 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Researchers have recently shown an increased interest in free radicals and their role in the tumor microenvironment. Free radicals are molecules with high instability and reactivity due to the presence of an odd number of electrons in the outermost orbit of their atoms. Free radicals include reactive oxygen and nitrogen species, which are key players in the initiation and progression of tumor cells and enhance their metastatic potential. In fact, they are now considered a hallmark of cancer. However, both reactive species may contribute to improve the outcomes of radiotherapy in cancer patients. Besides, high levels of reactive oxygen species may be indicators of genotoxic damage in non-irradiated normal tissues. The purpose of this article is to review recent research on free radicals and carcinogenesis in order to understand the pathways that contribute to tumor malignancy. This review outlines the involvement of free radicals in relevant cellular events, including their effects on genetic instability through (growth factors and tumor suppressor genes, their enhancement of mitogenic signals, and their participation in cell remodeling, proliferation, senescence, apoptosis, and autophagy processes; the possible relationship between free radicals and inflammation is also explored. This knowledge is crucial for evaluating the relevance of free radicals as therapeutic targets in cancer. Reactive Oxygen Species (dpeaa)DE-He213 Free Radical (dpeaa)DE-He213 Reactive Oxygen Species Production (dpeaa)DE-He213 Reactive Nitrogen Species (dpeaa)DE-He213 Total Antioxidant State (dpeaa)DE-He213 Artacho-Cordón, Francisco verfasserin aut León, Josefa verfasserin aut Román-Marinetto, Elisa verfasserin aut del Mar Salinas-Asensio, María verfasserin aut Calvente, Irene verfasserin aut Núñez, Maria Isabel verfasserin aut Enthalten in SpringerPlus London : Biomed Central, 2012 2(2013), 1 vom: 27. Aug. (DE-627)718615298 (DE-600)2661116-8 2193-1801 nnns volume:2 year:2013 number:1 day:27 month:08 https://dx.doi.org/10.1186/2193-1801-2-404 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2013 1 27 08
allfieldsGer	10.1186/2193-1801-2-404 doi (DE-627)SPR032751451 (SPR)2193-1801-2-404-e DE-627 ger DE-627 rakwb eng 600 ASE Ríos-Arrabal, Sandra verfasserin aut Involvement of free radicals in breast cancer 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Researchers have recently shown an increased interest in free radicals and their role in the tumor microenvironment. Free radicals are molecules with high instability and reactivity due to the presence of an odd number of electrons in the outermost orbit of their atoms. Free radicals include reactive oxygen and nitrogen species, which are key players in the initiation and progression of tumor cells and enhance their metastatic potential. In fact, they are now considered a hallmark of cancer. However, both reactive species may contribute to improve the outcomes of radiotherapy in cancer patients. Besides, high levels of reactive oxygen species may be indicators of genotoxic damage in non-irradiated normal tissues. The purpose of this article is to review recent research on free radicals and carcinogenesis in order to understand the pathways that contribute to tumor malignancy. This review outlines the involvement of free radicals in relevant cellular events, including their effects on genetic instability through (growth factors and tumor suppressor genes, their enhancement of mitogenic signals, and their participation in cell remodeling, proliferation, senescence, apoptosis, and autophagy processes; the possible relationship between free radicals and inflammation is also explored. This knowledge is crucial for evaluating the relevance of free radicals as therapeutic targets in cancer. Reactive Oxygen Species (dpeaa)DE-He213 Free Radical (dpeaa)DE-He213 Reactive Oxygen Species Production (dpeaa)DE-He213 Reactive Nitrogen Species (dpeaa)DE-He213 Total Antioxidant State (dpeaa)DE-He213 Artacho-Cordón, Francisco verfasserin aut León, Josefa verfasserin aut Román-Marinetto, Elisa verfasserin aut del Mar Salinas-Asensio, María verfasserin aut Calvente, Irene verfasserin aut Núñez, Maria Isabel verfasserin aut Enthalten in SpringerPlus London : Biomed Central, 2012 2(2013), 1 vom: 27. Aug. (DE-627)718615298 (DE-600)2661116-8 2193-1801 nnns volume:2 year:2013 number:1 day:27 month:08 https://dx.doi.org/10.1186/2193-1801-2-404 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2013 1 27 08
allfieldsSound	10.1186/2193-1801-2-404 doi (DE-627)SPR032751451 (SPR)2193-1801-2-404-e DE-627 ger DE-627 rakwb eng 600 ASE Ríos-Arrabal, Sandra verfasserin aut Involvement of free radicals in breast cancer 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Researchers have recently shown an increased interest in free radicals and their role in the tumor microenvironment. Free radicals are molecules with high instability and reactivity due to the presence of an odd number of electrons in the outermost orbit of their atoms. Free radicals include reactive oxygen and nitrogen species, which are key players in the initiation and progression of tumor cells and enhance their metastatic potential. In fact, they are now considered a hallmark of cancer. However, both reactive species may contribute to improve the outcomes of radiotherapy in cancer patients. Besides, high levels of reactive oxygen species may be indicators of genotoxic damage in non-irradiated normal tissues. The purpose of this article is to review recent research on free radicals and carcinogenesis in order to understand the pathways that contribute to tumor malignancy. This review outlines the involvement of free radicals in relevant cellular events, including their effects on genetic instability through (growth factors and tumor suppressor genes, their enhancement of mitogenic signals, and their participation in cell remodeling, proliferation, senescence, apoptosis, and autophagy processes; the possible relationship between free radicals and inflammation is also explored. This knowledge is crucial for evaluating the relevance of free radicals as therapeutic targets in cancer. Reactive Oxygen Species (dpeaa)DE-He213 Free Radical (dpeaa)DE-He213 Reactive Oxygen Species Production (dpeaa)DE-He213 Reactive Nitrogen Species (dpeaa)DE-He213 Total Antioxidant State (dpeaa)DE-He213 Artacho-Cordón, Francisco verfasserin aut León, Josefa verfasserin aut Román-Marinetto, Elisa verfasserin aut del Mar Salinas-Asensio, María verfasserin aut Calvente, Irene verfasserin aut Núñez, Maria Isabel verfasserin aut Enthalten in SpringerPlus London : Biomed Central, 2012 2(2013), 1 vom: 27. Aug. (DE-627)718615298 (DE-600)2661116-8 2193-1801 nnns volume:2 year:2013 number:1 day:27 month:08 https://dx.doi.org/10.1186/2193-1801-2-404 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2013 1 27 08
language	English
source	Enthalten in SpringerPlus 2(2013), 1 vom: 27. Aug. volume:2 year:2013 number:1 day:27 month:08
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topic_facet	Reactive Oxygen Species Free Radical Reactive Oxygen Species Production Reactive Nitrogen Species Total Antioxidant State
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container_title	SpringerPlus
authorswithroles_txt_mv	Ríos-Arrabal, Sandra @@aut@@ Artacho-Cordón, Francisco @@aut@@ León, Josefa @@aut@@ Román-Marinetto, Elisa @@aut@@ del Mar Salinas-Asensio, María @@aut@@ Calvente, Irene @@aut@@ Núñez, Maria Isabel @@aut@@
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author	Ríos-Arrabal, Sandra
spellingShingle	Ríos-Arrabal, Sandra ddc 600 misc Reactive Oxygen Species misc Free Radical misc Reactive Oxygen Species Production misc Reactive Nitrogen Species misc Total Antioxidant State Involvement of free radicals in breast cancer
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title	Involvement of free radicals in breast cancer
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title_full	Involvement of free radicals in breast cancer
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title_sort	involvement of free radicals in breast cancer
title_auth	Involvement of free radicals in breast cancer
abstract	Abstract Researchers have recently shown an increased interest in free radicals and their role in the tumor microenvironment. Free radicals are molecules with high instability and reactivity due to the presence of an odd number of electrons in the outermost orbit of their atoms. Free radicals include reactive oxygen and nitrogen species, which are key players in the initiation and progression of tumor cells and enhance their metastatic potential. In fact, they are now considered a hallmark of cancer. However, both reactive species may contribute to improve the outcomes of radiotherapy in cancer patients. Besides, high levels of reactive oxygen species may be indicators of genotoxic damage in non-irradiated normal tissues. The purpose of this article is to review recent research on free radicals and carcinogenesis in order to understand the pathways that contribute to tumor malignancy. This review outlines the involvement of free radicals in relevant cellular events, including their effects on genetic instability through (growth factors and tumor suppressor genes, their enhancement of mitogenic signals, and their participation in cell remodeling, proliferation, senescence, apoptosis, and autophagy processes; the possible relationship between free radicals and inflammation is also explored. This knowledge is crucial for evaluating the relevance of free radicals as therapeutic targets in cancer.
abstractGer	Abstract Researchers have recently shown an increased interest in free radicals and their role in the tumor microenvironment. Free radicals are molecules with high instability and reactivity due to the presence of an odd number of electrons in the outermost orbit of their atoms. Free radicals include reactive oxygen and nitrogen species, which are key players in the initiation and progression of tumor cells and enhance their metastatic potential. In fact, they are now considered a hallmark of cancer. However, both reactive species may contribute to improve the outcomes of radiotherapy in cancer patients. Besides, high levels of reactive oxygen species may be indicators of genotoxic damage in non-irradiated normal tissues. The purpose of this article is to review recent research on free radicals and carcinogenesis in order to understand the pathways that contribute to tumor malignancy. This review outlines the involvement of free radicals in relevant cellular events, including their effects on genetic instability through (growth factors and tumor suppressor genes, their enhancement of mitogenic signals, and their participation in cell remodeling, proliferation, senescence, apoptosis, and autophagy processes; the possible relationship between free radicals and inflammation is also explored. This knowledge is crucial for evaluating the relevance of free radicals as therapeutic targets in cancer.
abstract_unstemmed	Abstract Researchers have recently shown an increased interest in free radicals and their role in the tumor microenvironment. Free radicals are molecules with high instability and reactivity due to the presence of an odd number of electrons in the outermost orbit of their atoms. Free radicals include reactive oxygen and nitrogen species, which are key players in the initiation and progression of tumor cells and enhance their metastatic potential. In fact, they are now considered a hallmark of cancer. However, both reactive species may contribute to improve the outcomes of radiotherapy in cancer patients. Besides, high levels of reactive oxygen species may be indicators of genotoxic damage in non-irradiated normal tissues. The purpose of this article is to review recent research on free radicals and carcinogenesis in order to understand the pathways that contribute to tumor malignancy. This review outlines the involvement of free radicals in relevant cellular events, including their effects on genetic instability through (growth factors and tumor suppressor genes, their enhancement of mitogenic signals, and their participation in cell remodeling, proliferation, senescence, apoptosis, and autophagy processes; the possible relationship between free radicals and inflammation is also explored. This knowledge is crucial for evaluating the relevance of free radicals as therapeutic targets in cancer.
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title_short	Involvement of free radicals in breast cancer
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Involvement of free radicals in breast cancer

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