Longevity-associated mitochondrial DNA 5178 C/A polymorphism modulates the effects of coffee consumption on erythrocytic parameters in Japanese men: an exploratory cross-sectional analysis
Background Mitochondrial DNA 5178 cytosine/adenine (Mt5178 C/A) polymorphism reportedly modulates the effects of coffee consumption on the risk of hypertension, dyslipidemia and abnormal glucose tolerance. The objective of this analysis was to investigate whether Mt5178 C/A polymorphism modifies the...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Kokaze, Akatsuki [verfasserIn] Ishikawa, Mamoru [verfasserIn] Matsunaga, Naomi [verfasserIn] Karita, Kanae [verfasserIn] Yoshida, Masao [verfasserIn] Ohtsu, Tadahiro [verfasserIn] Ochiai, Hirotaka [verfasserIn] Shirasawa, Takako [verfasserIn] Nanri, Hinako [verfasserIn] Saga, Nobuyuki [verfasserIn] Ohtsu, Iichiro [verfasserIn] Hoshino, Hiromi [verfasserIn] Takashima, Yutaka [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Schlagwörter: |
Mitochondrial DNA polymorphism |
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| Übergeordnetes Werk: |
Enthalten in: Journal of physiological anthropology - Kawaguchi : J-STAGE, 2006, 33(2014), 1 vom: 20. Dez. |
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| Übergeordnetes Werk: |
volume:33 ; year:2014 ; number:1 ; day:20 ; month:12 |
| Links: |
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| DOI / URN: |
10.1186/1880-6805-33-37 |
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| Katalog-ID: |
SPR03285384X |
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| 245 | 1 | 0 | |a Longevity-associated mitochondrial DNA 5178 C/A polymorphism modulates the effects of coffee consumption on erythrocytic parameters in Japanese men: an exploratory cross-sectional analysis |
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| 520 | |a Background Mitochondrial DNA 5178 cytosine/adenine (Mt5178 C/A) polymorphism reportedly modulates the effects of coffee consumption on the risk of hypertension, dyslipidemia and abnormal glucose tolerance. The objective of this analysis was to investigate whether Mt5178 C/A polymorphism modifies the effects of coffee consumption on erythrocytic parameters in male Japanese health check-up examinees. Methods A total of 436 men (mean age ± standard deviation, 54.1 ± 7.8 years) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, an exploratory cross-sectional analysis assessing the joint effects of Mt5178 C/A polymorphism and coffee consumption on red blood cell counts, hematocrit and hemoglobin was conducted. Results For Mt5178C genotypic men, after adjustment for age, body mass index, alcohol consumption, habitual smoking and green tea consumption, coffee consumption significantly decreased red blood cell counts (P for trend = 0.022) and hemoglobin (P for trend = 0.035). The risk of anemia, defined as hemoglobin of <14 g/dL, after the aforementioned adjustment, appeared to depend on coffee consumption (P for trend = 0.078), and the adjusted odds ratio for anemia was significantly higher in men who consumed ≥4 cups of coffee per day than in those who consumed <1 cup per day (odds ratio = 3.771, 95% confidence interval: 1.088 to 13.06, P = 0.036). For Mt5178A genotypic men, coffee consumption possibly reduced the risk of anemia (P for trend = 0.049). However, after the aforementioned adjustment, the statistical significance disappeared (P for trend = 0.137). Conclusions This exploratory cross-sectional analysis suggests that Mt5178 C/A polymorphism modulates the effects of coffee consumption on erythrocytic parameters and the risk of anemia in male Japanese health check-up examinees. | ||
| 650 | 4 | |a Anemia |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Coffee consumption |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Hemoglobin |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Mitochondrial DNA polymorphism |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Personalized preventive medicine |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Red blood cell |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Ishikawa, Mamoru |e verfasserin |4 aut | |
| 700 | 1 | |a Matsunaga, Naomi |e verfasserin |4 aut | |
| 700 | 1 | |a Karita, Kanae |e verfasserin |4 aut | |
| 700 | 1 | |a Yoshida, Masao |e verfasserin |4 aut | |
| 700 | 1 | |a Ohtsu, Tadahiro |e verfasserin |4 aut | |
| 700 | 1 | |a Ochiai, Hirotaka |e verfasserin |4 aut | |
| 700 | 1 | |a Shirasawa, Takako |e verfasserin |4 aut | |
| 700 | 1 | |a Nanri, Hinako |e verfasserin |4 aut | |
| 700 | 1 | |a Saga, Nobuyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Ohtsu, Iichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Hoshino, Hiromi |e verfasserin |4 aut | |
| 700 | 1 | |a Takashima, Yutaka |e verfasserin |4 aut | |
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10.1186/1880-6805-33-37 doi (DE-627)SPR03285384X (SPR)1880-6805-33-37-e DE-627 ger DE-627 rakwb eng 610 ASE Kokaze, Akatsuki verfasserin aut Longevity-associated mitochondrial DNA 5178 C/A polymorphism modulates the effects of coffee consumption on erythrocytic parameters in Japanese men: an exploratory cross-sectional analysis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Mitochondrial DNA 5178 cytosine/adenine (Mt5178 C/A) polymorphism reportedly modulates the effects of coffee consumption on the risk of hypertension, dyslipidemia and abnormal glucose tolerance. The objective of this analysis was to investigate whether Mt5178 C/A polymorphism modifies the effects of coffee consumption on erythrocytic parameters in male Japanese health check-up examinees. Methods A total of 436 men (mean age ± standard deviation, 54.1 ± 7.8 years) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, an exploratory cross-sectional analysis assessing the joint effects of Mt5178 C/A polymorphism and coffee consumption on red blood cell counts, hematocrit and hemoglobin was conducted. Results For Mt5178C genotypic men, after adjustment for age, body mass index, alcohol consumption, habitual smoking and green tea consumption, coffee consumption significantly decreased red blood cell counts (P for trend = 0.022) and hemoglobin (P for trend = 0.035). The risk of anemia, defined as hemoglobin of <14 g/dL, after the aforementioned adjustment, appeared to depend on coffee consumption (P for trend = 0.078), and the adjusted odds ratio for anemia was significantly higher in men who consumed ≥4 cups of coffee per day than in those who consumed <1 cup per day (odds ratio = 3.771, 95% confidence interval: 1.088 to 13.06, P = 0.036). For Mt5178A genotypic men, coffee consumption possibly reduced the risk of anemia (P for trend = 0.049). However, after the aforementioned adjustment, the statistical significance disappeared (P for trend = 0.137). Conclusions This exploratory cross-sectional analysis suggests that Mt5178 C/A polymorphism modulates the effects of coffee consumption on erythrocytic parameters and the risk of anemia in male Japanese health check-up examinees. Anemia (dpeaa)DE-He213 Coffee consumption (dpeaa)DE-He213 Hemoglobin (dpeaa)DE-He213 Mitochondrial DNA polymorphism (dpeaa)DE-He213 Personalized preventive medicine (dpeaa)DE-He213 Red blood cell (dpeaa)DE-He213 Ishikawa, Mamoru verfasserin aut Matsunaga, Naomi verfasserin aut Karita, Kanae verfasserin aut Yoshida, Masao verfasserin aut Ohtsu, Tadahiro verfasserin aut Ochiai, Hirotaka verfasserin aut Shirasawa, Takako verfasserin aut Nanri, Hinako verfasserin aut Saga, Nobuyuki verfasserin aut Ohtsu, Iichiro verfasserin aut Hoshino, Hiromi verfasserin aut Takashima, Yutaka verfasserin aut Enthalten in Journal of physiological anthropology Kawaguchi : J-STAGE, 2006 33(2014), 1 vom: 20. Dez. (DE-627)516802429 (DE-600)2248082-1 1880-6805 nnns volume:33 year:2014 number:1 day:20 month:12 https://dx.doi.org/10.1186/1880-6805-33-37 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 33 2014 1 20 12 |
| spelling |
10.1186/1880-6805-33-37 doi (DE-627)SPR03285384X (SPR)1880-6805-33-37-e DE-627 ger DE-627 rakwb eng 610 ASE Kokaze, Akatsuki verfasserin aut Longevity-associated mitochondrial DNA 5178 C/A polymorphism modulates the effects of coffee consumption on erythrocytic parameters in Japanese men: an exploratory cross-sectional analysis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Mitochondrial DNA 5178 cytosine/adenine (Mt5178 C/A) polymorphism reportedly modulates the effects of coffee consumption on the risk of hypertension, dyslipidemia and abnormal glucose tolerance. The objective of this analysis was to investigate whether Mt5178 C/A polymorphism modifies the effects of coffee consumption on erythrocytic parameters in male Japanese health check-up examinees. Methods A total of 436 men (mean age ± standard deviation, 54.1 ± 7.8 years) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, an exploratory cross-sectional analysis assessing the joint effects of Mt5178 C/A polymorphism and coffee consumption on red blood cell counts, hematocrit and hemoglobin was conducted. Results For Mt5178C genotypic men, after adjustment for age, body mass index, alcohol consumption, habitual smoking and green tea consumption, coffee consumption significantly decreased red blood cell counts (P for trend = 0.022) and hemoglobin (P for trend = 0.035). The risk of anemia, defined as hemoglobin of <14 g/dL, after the aforementioned adjustment, appeared to depend on coffee consumption (P for trend = 0.078), and the adjusted odds ratio for anemia was significantly higher in men who consumed ≥4 cups of coffee per day than in those who consumed <1 cup per day (odds ratio = 3.771, 95% confidence interval: 1.088 to 13.06, P = 0.036). For Mt5178A genotypic men, coffee consumption possibly reduced the risk of anemia (P for trend = 0.049). However, after the aforementioned adjustment, the statistical significance disappeared (P for trend = 0.137). Conclusions This exploratory cross-sectional analysis suggests that Mt5178 C/A polymorphism modulates the effects of coffee consumption on erythrocytic parameters and the risk of anemia in male Japanese health check-up examinees. Anemia (dpeaa)DE-He213 Coffee consumption (dpeaa)DE-He213 Hemoglobin (dpeaa)DE-He213 Mitochondrial DNA polymorphism (dpeaa)DE-He213 Personalized preventive medicine (dpeaa)DE-He213 Red blood cell (dpeaa)DE-He213 Ishikawa, Mamoru verfasserin aut Matsunaga, Naomi verfasserin aut Karita, Kanae verfasserin aut Yoshida, Masao verfasserin aut Ohtsu, Tadahiro verfasserin aut Ochiai, Hirotaka verfasserin aut Shirasawa, Takako verfasserin aut Nanri, Hinako verfasserin aut Saga, Nobuyuki verfasserin aut Ohtsu, Iichiro verfasserin aut Hoshino, Hiromi verfasserin aut Takashima, Yutaka verfasserin aut Enthalten in Journal of physiological anthropology Kawaguchi : J-STAGE, 2006 33(2014), 1 vom: 20. Dez. (DE-627)516802429 (DE-600)2248082-1 1880-6805 nnns volume:33 year:2014 number:1 day:20 month:12 https://dx.doi.org/10.1186/1880-6805-33-37 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 33 2014 1 20 12 |
| allfields_unstemmed |
10.1186/1880-6805-33-37 doi (DE-627)SPR03285384X (SPR)1880-6805-33-37-e DE-627 ger DE-627 rakwb eng 610 ASE Kokaze, Akatsuki verfasserin aut Longevity-associated mitochondrial DNA 5178 C/A polymorphism modulates the effects of coffee consumption on erythrocytic parameters in Japanese men: an exploratory cross-sectional analysis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Mitochondrial DNA 5178 cytosine/adenine (Mt5178 C/A) polymorphism reportedly modulates the effects of coffee consumption on the risk of hypertension, dyslipidemia and abnormal glucose tolerance. The objective of this analysis was to investigate whether Mt5178 C/A polymorphism modifies the effects of coffee consumption on erythrocytic parameters in male Japanese health check-up examinees. Methods A total of 436 men (mean age ± standard deviation, 54.1 ± 7.8 years) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, an exploratory cross-sectional analysis assessing the joint effects of Mt5178 C/A polymorphism and coffee consumption on red blood cell counts, hematocrit and hemoglobin was conducted. Results For Mt5178C genotypic men, after adjustment for age, body mass index, alcohol consumption, habitual smoking and green tea consumption, coffee consumption significantly decreased red blood cell counts (P for trend = 0.022) and hemoglobin (P for trend = 0.035). The risk of anemia, defined as hemoglobin of <14 g/dL, after the aforementioned adjustment, appeared to depend on coffee consumption (P for trend = 0.078), and the adjusted odds ratio for anemia was significantly higher in men who consumed ≥4 cups of coffee per day than in those who consumed <1 cup per day (odds ratio = 3.771, 95% confidence interval: 1.088 to 13.06, P = 0.036). For Mt5178A genotypic men, coffee consumption possibly reduced the risk of anemia (P for trend = 0.049). However, after the aforementioned adjustment, the statistical significance disappeared (P for trend = 0.137). Conclusions This exploratory cross-sectional analysis suggests that Mt5178 C/A polymorphism modulates the effects of coffee consumption on erythrocytic parameters and the risk of anemia in male Japanese health check-up examinees. Anemia (dpeaa)DE-He213 Coffee consumption (dpeaa)DE-He213 Hemoglobin (dpeaa)DE-He213 Mitochondrial DNA polymorphism (dpeaa)DE-He213 Personalized preventive medicine (dpeaa)DE-He213 Red blood cell (dpeaa)DE-He213 Ishikawa, Mamoru verfasserin aut Matsunaga, Naomi verfasserin aut Karita, Kanae verfasserin aut Yoshida, Masao verfasserin aut Ohtsu, Tadahiro verfasserin aut Ochiai, Hirotaka verfasserin aut Shirasawa, Takako verfasserin aut Nanri, Hinako verfasserin aut Saga, Nobuyuki verfasserin aut Ohtsu, Iichiro verfasserin aut Hoshino, Hiromi verfasserin aut Takashima, Yutaka verfasserin aut Enthalten in Journal of physiological anthropology Kawaguchi : J-STAGE, 2006 33(2014), 1 vom: 20. Dez. (DE-627)516802429 (DE-600)2248082-1 1880-6805 nnns volume:33 year:2014 number:1 day:20 month:12 https://dx.doi.org/10.1186/1880-6805-33-37 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 33 2014 1 20 12 |
| allfieldsGer |
10.1186/1880-6805-33-37 doi (DE-627)SPR03285384X (SPR)1880-6805-33-37-e DE-627 ger DE-627 rakwb eng 610 ASE Kokaze, Akatsuki verfasserin aut Longevity-associated mitochondrial DNA 5178 C/A polymorphism modulates the effects of coffee consumption on erythrocytic parameters in Japanese men: an exploratory cross-sectional analysis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Mitochondrial DNA 5178 cytosine/adenine (Mt5178 C/A) polymorphism reportedly modulates the effects of coffee consumption on the risk of hypertension, dyslipidemia and abnormal glucose tolerance. The objective of this analysis was to investigate whether Mt5178 C/A polymorphism modifies the effects of coffee consumption on erythrocytic parameters in male Japanese health check-up examinees. Methods A total of 436 men (mean age ± standard deviation, 54.1 ± 7.8 years) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, an exploratory cross-sectional analysis assessing the joint effects of Mt5178 C/A polymorphism and coffee consumption on red blood cell counts, hematocrit and hemoglobin was conducted. Results For Mt5178C genotypic men, after adjustment for age, body mass index, alcohol consumption, habitual smoking and green tea consumption, coffee consumption significantly decreased red blood cell counts (P for trend = 0.022) and hemoglobin (P for trend = 0.035). The risk of anemia, defined as hemoglobin of <14 g/dL, after the aforementioned adjustment, appeared to depend on coffee consumption (P for trend = 0.078), and the adjusted odds ratio for anemia was significantly higher in men who consumed ≥4 cups of coffee per day than in those who consumed <1 cup per day (odds ratio = 3.771, 95% confidence interval: 1.088 to 13.06, P = 0.036). For Mt5178A genotypic men, coffee consumption possibly reduced the risk of anemia (P for trend = 0.049). However, after the aforementioned adjustment, the statistical significance disappeared (P for trend = 0.137). Conclusions This exploratory cross-sectional analysis suggests that Mt5178 C/A polymorphism modulates the effects of coffee consumption on erythrocytic parameters and the risk of anemia in male Japanese health check-up examinees. Anemia (dpeaa)DE-He213 Coffee consumption (dpeaa)DE-He213 Hemoglobin (dpeaa)DE-He213 Mitochondrial DNA polymorphism (dpeaa)DE-He213 Personalized preventive medicine (dpeaa)DE-He213 Red blood cell (dpeaa)DE-He213 Ishikawa, Mamoru verfasserin aut Matsunaga, Naomi verfasserin aut Karita, Kanae verfasserin aut Yoshida, Masao verfasserin aut Ohtsu, Tadahiro verfasserin aut Ochiai, Hirotaka verfasserin aut Shirasawa, Takako verfasserin aut Nanri, Hinako verfasserin aut Saga, Nobuyuki verfasserin aut Ohtsu, Iichiro verfasserin aut Hoshino, Hiromi verfasserin aut Takashima, Yutaka verfasserin aut Enthalten in Journal of physiological anthropology Kawaguchi : J-STAGE, 2006 33(2014), 1 vom: 20. Dez. (DE-627)516802429 (DE-600)2248082-1 1880-6805 nnns volume:33 year:2014 number:1 day:20 month:12 https://dx.doi.org/10.1186/1880-6805-33-37 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 33 2014 1 20 12 |
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10.1186/1880-6805-33-37 doi (DE-627)SPR03285384X (SPR)1880-6805-33-37-e DE-627 ger DE-627 rakwb eng 610 ASE Kokaze, Akatsuki verfasserin aut Longevity-associated mitochondrial DNA 5178 C/A polymorphism modulates the effects of coffee consumption on erythrocytic parameters in Japanese men: an exploratory cross-sectional analysis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Mitochondrial DNA 5178 cytosine/adenine (Mt5178 C/A) polymorphism reportedly modulates the effects of coffee consumption on the risk of hypertension, dyslipidemia and abnormal glucose tolerance. The objective of this analysis was to investigate whether Mt5178 C/A polymorphism modifies the effects of coffee consumption on erythrocytic parameters in male Japanese health check-up examinees. Methods A total of 436 men (mean age ± standard deviation, 54.1 ± 7.8 years) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, an exploratory cross-sectional analysis assessing the joint effects of Mt5178 C/A polymorphism and coffee consumption on red blood cell counts, hematocrit and hemoglobin was conducted. Results For Mt5178C genotypic men, after adjustment for age, body mass index, alcohol consumption, habitual smoking and green tea consumption, coffee consumption significantly decreased red blood cell counts (P for trend = 0.022) and hemoglobin (P for trend = 0.035). The risk of anemia, defined as hemoglobin of <14 g/dL, after the aforementioned adjustment, appeared to depend on coffee consumption (P for trend = 0.078), and the adjusted odds ratio for anemia was significantly higher in men who consumed ≥4 cups of coffee per day than in those who consumed <1 cup per day (odds ratio = 3.771, 95% confidence interval: 1.088 to 13.06, P = 0.036). For Mt5178A genotypic men, coffee consumption possibly reduced the risk of anemia (P for trend = 0.049). However, after the aforementioned adjustment, the statistical significance disappeared (P for trend = 0.137). Conclusions This exploratory cross-sectional analysis suggests that Mt5178 C/A polymorphism modulates the effects of coffee consumption on erythrocytic parameters and the risk of anemia in male Japanese health check-up examinees. Anemia (dpeaa)DE-He213 Coffee consumption (dpeaa)DE-He213 Hemoglobin (dpeaa)DE-He213 Mitochondrial DNA polymorphism (dpeaa)DE-He213 Personalized preventive medicine (dpeaa)DE-He213 Red blood cell (dpeaa)DE-He213 Ishikawa, Mamoru verfasserin aut Matsunaga, Naomi verfasserin aut Karita, Kanae verfasserin aut Yoshida, Masao verfasserin aut Ohtsu, Tadahiro verfasserin aut Ochiai, Hirotaka verfasserin aut Shirasawa, Takako verfasserin aut Nanri, Hinako verfasserin aut Saga, Nobuyuki verfasserin aut Ohtsu, Iichiro verfasserin aut Hoshino, Hiromi verfasserin aut Takashima, Yutaka verfasserin aut Enthalten in Journal of physiological anthropology Kawaguchi : J-STAGE, 2006 33(2014), 1 vom: 20. Dez. (DE-627)516802429 (DE-600)2248082-1 1880-6805 nnns volume:33 year:2014 number:1 day:20 month:12 https://dx.doi.org/10.1186/1880-6805-33-37 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 33 2014 1 20 12 |
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The objective of this analysis was to investigate whether Mt5178 C/A polymorphism modifies the effects of coffee consumption on erythrocytic parameters in male Japanese health check-up examinees. Methods A total of 436 men (mean age ± standard deviation, 54.1 ± 7.8 years) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, an exploratory cross-sectional analysis assessing the joint effects of Mt5178 C/A polymorphism and coffee consumption on red blood cell counts, hematocrit and hemoglobin was conducted. Results For Mt5178C genotypic men, after adjustment for age, body mass index, alcohol consumption, habitual smoking and green tea consumption, coffee consumption significantly decreased red blood cell counts (P for trend = 0.022) and hemoglobin (P for trend = 0.035). The risk of anemia, defined as hemoglobin of <14 g/dL, after the aforementioned adjustment, appeared to depend on coffee consumption (P for trend = 0.078), and the adjusted odds ratio for anemia was significantly higher in men who consumed ≥4 cups of coffee per day than in those who consumed <1 cup per day (odds ratio = 3.771, 95% confidence interval: 1.088 to 13.06, P = 0.036). For Mt5178A genotypic men, coffee consumption possibly reduced the risk of anemia (P for trend = 0.049). However, after the aforementioned adjustment, the statistical significance disappeared (P for trend = 0.137). 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Kokaze, Akatsuki Ishikawa, Mamoru Matsunaga, Naomi Karita, Kanae Yoshida, Masao Ohtsu, Tadahiro Ochiai, Hirotaka Shirasawa, Takako Nanri, Hinako Saga, Nobuyuki Ohtsu, Iichiro Hoshino, Hiromi Takashima, Yutaka |
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longevity-associated mitochondrial dna 5178 c/a polymorphism modulates the effects of coffee consumption on erythrocytic parameters in japanese men: an exploratory cross-sectional analysis |
| title_auth |
Longevity-associated mitochondrial DNA 5178 C/A polymorphism modulates the effects of coffee consumption on erythrocytic parameters in Japanese men: an exploratory cross-sectional analysis |
| abstract |
Background Mitochondrial DNA 5178 cytosine/adenine (Mt5178 C/A) polymorphism reportedly modulates the effects of coffee consumption on the risk of hypertension, dyslipidemia and abnormal glucose tolerance. The objective of this analysis was to investigate whether Mt5178 C/A polymorphism modifies the effects of coffee consumption on erythrocytic parameters in male Japanese health check-up examinees. Methods A total of 436 men (mean age ± standard deviation, 54.1 ± 7.8 years) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, an exploratory cross-sectional analysis assessing the joint effects of Mt5178 C/A polymorphism and coffee consumption on red blood cell counts, hematocrit and hemoglobin was conducted. Results For Mt5178C genotypic men, after adjustment for age, body mass index, alcohol consumption, habitual smoking and green tea consumption, coffee consumption significantly decreased red blood cell counts (P for trend = 0.022) and hemoglobin (P for trend = 0.035). The risk of anemia, defined as hemoglobin of <14 g/dL, after the aforementioned adjustment, appeared to depend on coffee consumption (P for trend = 0.078), and the adjusted odds ratio for anemia was significantly higher in men who consumed ≥4 cups of coffee per day than in those who consumed <1 cup per day (odds ratio = 3.771, 95% confidence interval: 1.088 to 13.06, P = 0.036). For Mt5178A genotypic men, coffee consumption possibly reduced the risk of anemia (P for trend = 0.049). However, after the aforementioned adjustment, the statistical significance disappeared (P for trend = 0.137). Conclusions This exploratory cross-sectional analysis suggests that Mt5178 C/A polymorphism modulates the effects of coffee consumption on erythrocytic parameters and the risk of anemia in male Japanese health check-up examinees. |
| abstractGer |
Background Mitochondrial DNA 5178 cytosine/adenine (Mt5178 C/A) polymorphism reportedly modulates the effects of coffee consumption on the risk of hypertension, dyslipidemia and abnormal glucose tolerance. The objective of this analysis was to investigate whether Mt5178 C/A polymorphism modifies the effects of coffee consumption on erythrocytic parameters in male Japanese health check-up examinees. Methods A total of 436 men (mean age ± standard deviation, 54.1 ± 7.8 years) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, an exploratory cross-sectional analysis assessing the joint effects of Mt5178 C/A polymorphism and coffee consumption on red blood cell counts, hematocrit and hemoglobin was conducted. Results For Mt5178C genotypic men, after adjustment for age, body mass index, alcohol consumption, habitual smoking and green tea consumption, coffee consumption significantly decreased red blood cell counts (P for trend = 0.022) and hemoglobin (P for trend = 0.035). The risk of anemia, defined as hemoglobin of <14 g/dL, after the aforementioned adjustment, appeared to depend on coffee consumption (P for trend = 0.078), and the adjusted odds ratio for anemia was significantly higher in men who consumed ≥4 cups of coffee per day than in those who consumed <1 cup per day (odds ratio = 3.771, 95% confidence interval: 1.088 to 13.06, P = 0.036). For Mt5178A genotypic men, coffee consumption possibly reduced the risk of anemia (P for trend = 0.049). However, after the aforementioned adjustment, the statistical significance disappeared (P for trend = 0.137). Conclusions This exploratory cross-sectional analysis suggests that Mt5178 C/A polymorphism modulates the effects of coffee consumption on erythrocytic parameters and the risk of anemia in male Japanese health check-up examinees. |
| abstract_unstemmed |
Background Mitochondrial DNA 5178 cytosine/adenine (Mt5178 C/A) polymorphism reportedly modulates the effects of coffee consumption on the risk of hypertension, dyslipidemia and abnormal glucose tolerance. The objective of this analysis was to investigate whether Mt5178 C/A polymorphism modifies the effects of coffee consumption on erythrocytic parameters in male Japanese health check-up examinees. Methods A total of 436 men (mean age ± standard deviation, 54.1 ± 7.8 years) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, an exploratory cross-sectional analysis assessing the joint effects of Mt5178 C/A polymorphism and coffee consumption on red blood cell counts, hematocrit and hemoglobin was conducted. Results For Mt5178C genotypic men, after adjustment for age, body mass index, alcohol consumption, habitual smoking and green tea consumption, coffee consumption significantly decreased red blood cell counts (P for trend = 0.022) and hemoglobin (P for trend = 0.035). The risk of anemia, defined as hemoglobin of <14 g/dL, after the aforementioned adjustment, appeared to depend on coffee consumption (P for trend = 0.078), and the adjusted odds ratio for anemia was significantly higher in men who consumed ≥4 cups of coffee per day than in those who consumed <1 cup per day (odds ratio = 3.771, 95% confidence interval: 1.088 to 13.06, P = 0.036). For Mt5178A genotypic men, coffee consumption possibly reduced the risk of anemia (P for trend = 0.049). However, after the aforementioned adjustment, the statistical significance disappeared (P for trend = 0.137). Conclusions This exploratory cross-sectional analysis suggests that Mt5178 C/A polymorphism modulates the effects of coffee consumption on erythrocytic parameters and the risk of anemia in male Japanese health check-up examinees. |
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Longevity-associated mitochondrial DNA 5178 C/A polymorphism modulates the effects of coffee consumption on erythrocytic parameters in Japanese men: an exploratory cross-sectional analysis |
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Ishikawa, Mamoru Matsunaga, Naomi Karita, Kanae Yoshida, Masao Ohtsu, Tadahiro Ochiai, Hirotaka Shirasawa, Takako Nanri, Hinako Saga, Nobuyuki Ohtsu, Iichiro Hoshino, Hiromi Takashima, Yutaka |
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Ishikawa, Mamoru Matsunaga, Naomi Karita, Kanae Yoshida, Masao Ohtsu, Tadahiro Ochiai, Hirotaka Shirasawa, Takako Nanri, Hinako Saga, Nobuyuki Ohtsu, Iichiro Hoshino, Hiromi Takashima, Yutaka |
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