Difference in effects of cigarette smoking or alcohol consumption on serum non-high-density lipoprotein cholesterol levels is related to mitochondrial DNA 5178 C/A polymorphism in middle-aged Japanese men: a cross-sectional study

Background Mitochondrial DNA 5178 cytosine/adenosine (Mt5178 C/A) polymorphism is associated with longevity in the Japanese. The purpose of this study is to investigate whether Mt5178 C/A polymorphism modifies the effects of habitual smoking or habitual drinking on serum non-high-density lipoprotein...
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Autor*in:	Kokaze, Akatsuki [verfasserIn] Ishikawa, Mamoru [verfasserIn] Matsunaga, Naomi [verfasserIn] Karita, Kanae [verfasserIn] Yoshida, Masao [verfasserIn] Ohtsu, Tadahiro [verfasserIn] Ochiai, Hirotaka [verfasserIn] Shirasawa, Takako [verfasserIn] Nanri, Hinako [verfasserIn] Hoshino, Hiromi [verfasserIn] Takashima, Yutaka [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	Alcohol consumption Cigarette smoking Longevity Mitochondrial DNA polymorphism Non-HDL cholesterol

Übergeordnetes Werk:	Enthalten in: Journal of physiological anthropology - Kawaguchi : J-STAGE, 2006, 33(2014), 1 vom: 03. Jan.
Übergeordnetes Werk:	volume:33 ; year:2014 ; number:1 ; day:03 ; month:01

Links:	Volltext

DOI / URN:	10.1186/1880-6805-33-1

Katalog-ID:	SPR032853874

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245	1	0	\|a Difference in effects of cigarette smoking or alcohol consumption on serum non-high-density lipoprotein cholesterol levels is related to mitochondrial DNA 5178 C/A polymorphism in middle-aged Japanese men: a cross-sectional study
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520			\|a Background Mitochondrial DNA 5178 cytosine/adenosine (Mt5178 C/A) polymorphism is associated with longevity in the Japanese. The purpose of this study is to investigate whether Mt5178 C/A polymorphism modifies the effects of habitual smoking or habitual drinking on serum non-high-density lipoprotein (non-HDL) cholesterol levels in middle-aged Japanese men. Methods A total of 394 male subjects (age 53.9 ± 7.9 years; mean ± SD) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the joint effects of Mt5178 C/A polymorphism and cigarette smoking or alcohol drinking on serum non-HDL cholesterol levels was conducted. High levels of serum non-HDL cholesterol were defined as serum non-HDL cholesterol levels ≥160 mg/dl or ≥190 mg/dl. Results For men with Mt5178A, cigarette smoking may increase serum non-HDL cholesterol levels (P for trend < 0.001), as well as the risk of high levels of non-HDL cholesterol (serum non-HDL cholesterol levels ≥160 mg/dl, P for trend < 0.001; serum non-HDL cholesterol levels ≥190 mg/dl, P for trend = 0.004). On the other hand, for men with Mt5178C, after adjusting for age and body mass index, alcohol consumption may decrease serum non-HDL cholesterol levels (P for trend = 0.043) and the risk of high levels of non-HDL cholesterol (serum non-HDL cholesterol level ≥160 mg/dl, P for trend = 0.005). Conclusions These gene-environment interactions on serum non-HDL cholesterol levels may contribute to the establishment of individualized prevention of the risk of high levels of serum non-HDL cholesterol.
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650		4	\|a Cigarette smoking \|7 (dpeaa)DE-He213
650		4	\|a Longevity \|7 (dpeaa)DE-He213
650		4	\|a Mitochondrial DNA polymorphism \|7 (dpeaa)DE-He213
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700	1		\|a Hoshino, Hiromi \|e verfasserin \|4 aut
700	1		\|a Takashima, Yutaka \|e verfasserin \|4 aut
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author_variant	a k ak m i mi n m nm k k kk m y my t o to h o ho t s ts h n hn h h hh y t yt
matchkey_str	article:18806805:2014----::ifrnenfetocgrtemknoachlosmtoosrmohgdniyiorticoetrleesseaetmtcodiln57cplm
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allfields	10.1186/1880-6805-33-1 doi (DE-627)SPR032853874 (SPR)1880-6805-33-1-e DE-627 ger DE-627 rakwb eng 610 ASE Kokaze, Akatsuki verfasserin aut Difference in effects of cigarette smoking or alcohol consumption on serum non-high-density lipoprotein cholesterol levels is related to mitochondrial DNA 5178 C/A polymorphism in middle-aged Japanese men: a cross-sectional study 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Mitochondrial DNA 5178 cytosine/adenosine (Mt5178 C/A) polymorphism is associated with longevity in the Japanese. The purpose of this study is to investigate whether Mt5178 C/A polymorphism modifies the effects of habitual smoking or habitual drinking on serum non-high-density lipoprotein (non-HDL) cholesterol levels in middle-aged Japanese men. Methods A total of 394 male subjects (age 53.9 ± 7.9 years; mean ± SD) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the joint effects of Mt5178 C/A polymorphism and cigarette smoking or alcohol drinking on serum non-HDL cholesterol levels was conducted. High levels of serum non-HDL cholesterol were defined as serum non-HDL cholesterol levels ≥160 mg/dl or ≥190 mg/dl. Results For men with Mt5178A, cigarette smoking may increase serum non-HDL cholesterol levels (P for trend < 0.001), as well as the risk of high levels of non-HDL cholesterol (serum non-HDL cholesterol levels ≥160 mg/dl, P for trend < 0.001; serum non-HDL cholesterol levels ≥190 mg/dl, P for trend = 0.004). On the other hand, for men with Mt5178C, after adjusting for age and body mass index, alcohol consumption may decrease serum non-HDL cholesterol levels (P for trend = 0.043) and the risk of high levels of non-HDL cholesterol (serum non-HDL cholesterol level ≥160 mg/dl, P for trend = 0.005). Conclusions These gene-environment interactions on serum non-HDL cholesterol levels may contribute to the establishment of individualized prevention of the risk of high levels of serum non-HDL cholesterol. Alcohol consumption (dpeaa)DE-He213 Cigarette smoking (dpeaa)DE-He213 Longevity (dpeaa)DE-He213 Mitochondrial DNA polymorphism (dpeaa)DE-He213 Non-HDL cholesterol (dpeaa)DE-He213 Ishikawa, Mamoru verfasserin aut Matsunaga, Naomi verfasserin aut Karita, Kanae verfasserin aut Yoshida, Masao verfasserin aut Ohtsu, Tadahiro verfasserin aut Ochiai, Hirotaka verfasserin aut Shirasawa, Takako verfasserin aut Nanri, Hinako verfasserin aut Hoshino, Hiromi verfasserin aut Takashima, Yutaka verfasserin aut Enthalten in Journal of physiological anthropology Kawaguchi : J-STAGE, 2006 33(2014), 1 vom: 03. Jan. (DE-627)516802429 (DE-600)2248082-1 1880-6805 nnns volume:33 year:2014 number:1 day:03 month:01 https://dx.doi.org/10.1186/1880-6805-33-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 33 2014 1 03 01
spelling	10.1186/1880-6805-33-1 doi (DE-627)SPR032853874 (SPR)1880-6805-33-1-e DE-627 ger DE-627 rakwb eng 610 ASE Kokaze, Akatsuki verfasserin aut Difference in effects of cigarette smoking or alcohol consumption on serum non-high-density lipoprotein cholesterol levels is related to mitochondrial DNA 5178 C/A polymorphism in middle-aged Japanese men: a cross-sectional study 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Mitochondrial DNA 5178 cytosine/adenosine (Mt5178 C/A) polymorphism is associated with longevity in the Japanese. The purpose of this study is to investigate whether Mt5178 C/A polymorphism modifies the effects of habitual smoking or habitual drinking on serum non-high-density lipoprotein (non-HDL) cholesterol levels in middle-aged Japanese men. Methods A total of 394 male subjects (age 53.9 ± 7.9 years; mean ± SD) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the joint effects of Mt5178 C/A polymorphism and cigarette smoking or alcohol drinking on serum non-HDL cholesterol levels was conducted. High levels of serum non-HDL cholesterol were defined as serum non-HDL cholesterol levels ≥160 mg/dl or ≥190 mg/dl. Results For men with Mt5178A, cigarette smoking may increase serum non-HDL cholesterol levels (P for trend < 0.001), as well as the risk of high levels of non-HDL cholesterol (serum non-HDL cholesterol levels ≥160 mg/dl, P for trend < 0.001; serum non-HDL cholesterol levels ≥190 mg/dl, P for trend = 0.004). On the other hand, for men with Mt5178C, after adjusting for age and body mass index, alcohol consumption may decrease serum non-HDL cholesterol levels (P for trend = 0.043) and the risk of high levels of non-HDL cholesterol (serum non-HDL cholesterol level ≥160 mg/dl, P for trend = 0.005). Conclusions These gene-environment interactions on serum non-HDL cholesterol levels may contribute to the establishment of individualized prevention of the risk of high levels of serum non-HDL cholesterol. Alcohol consumption (dpeaa)DE-He213 Cigarette smoking (dpeaa)DE-He213 Longevity (dpeaa)DE-He213 Mitochondrial DNA polymorphism (dpeaa)DE-He213 Non-HDL cholesterol (dpeaa)DE-He213 Ishikawa, Mamoru verfasserin aut Matsunaga, Naomi verfasserin aut Karita, Kanae verfasserin aut Yoshida, Masao verfasserin aut Ohtsu, Tadahiro verfasserin aut Ochiai, Hirotaka verfasserin aut Shirasawa, Takako verfasserin aut Nanri, Hinako verfasserin aut Hoshino, Hiromi verfasserin aut Takashima, Yutaka verfasserin aut Enthalten in Journal of physiological anthropology Kawaguchi : J-STAGE, 2006 33(2014), 1 vom: 03. Jan. (DE-627)516802429 (DE-600)2248082-1 1880-6805 nnns volume:33 year:2014 number:1 day:03 month:01 https://dx.doi.org/10.1186/1880-6805-33-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 33 2014 1 03 01
allfields_unstemmed	10.1186/1880-6805-33-1 doi (DE-627)SPR032853874 (SPR)1880-6805-33-1-e DE-627 ger DE-627 rakwb eng 610 ASE Kokaze, Akatsuki verfasserin aut Difference in effects of cigarette smoking or alcohol consumption on serum non-high-density lipoprotein cholesterol levels is related to mitochondrial DNA 5178 C/A polymorphism in middle-aged Japanese men: a cross-sectional study 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Mitochondrial DNA 5178 cytosine/adenosine (Mt5178 C/A) polymorphism is associated with longevity in the Japanese. The purpose of this study is to investigate whether Mt5178 C/A polymorphism modifies the effects of habitual smoking or habitual drinking on serum non-high-density lipoprotein (non-HDL) cholesterol levels in middle-aged Japanese men. Methods A total of 394 male subjects (age 53.9 ± 7.9 years; mean ± SD) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the joint effects of Mt5178 C/A polymorphism and cigarette smoking or alcohol drinking on serum non-HDL cholesterol levels was conducted. High levels of serum non-HDL cholesterol were defined as serum non-HDL cholesterol levels ≥160 mg/dl or ≥190 mg/dl. Results For men with Mt5178A, cigarette smoking may increase serum non-HDL cholesterol levels (P for trend < 0.001), as well as the risk of high levels of non-HDL cholesterol (serum non-HDL cholesterol levels ≥160 mg/dl, P for trend < 0.001; serum non-HDL cholesterol levels ≥190 mg/dl, P for trend = 0.004). On the other hand, for men with Mt5178C, after adjusting for age and body mass index, alcohol consumption may decrease serum non-HDL cholesterol levels (P for trend = 0.043) and the risk of high levels of non-HDL cholesterol (serum non-HDL cholesterol level ≥160 mg/dl, P for trend = 0.005). Conclusions These gene-environment interactions on serum non-HDL cholesterol levels may contribute to the establishment of individualized prevention of the risk of high levels of serum non-HDL cholesterol. Alcohol consumption (dpeaa)DE-He213 Cigarette smoking (dpeaa)DE-He213 Longevity (dpeaa)DE-He213 Mitochondrial DNA polymorphism (dpeaa)DE-He213 Non-HDL cholesterol (dpeaa)DE-He213 Ishikawa, Mamoru verfasserin aut Matsunaga, Naomi verfasserin aut Karita, Kanae verfasserin aut Yoshida, Masao verfasserin aut Ohtsu, Tadahiro verfasserin aut Ochiai, Hirotaka verfasserin aut Shirasawa, Takako verfasserin aut Nanri, Hinako verfasserin aut Hoshino, Hiromi verfasserin aut Takashima, Yutaka verfasserin aut Enthalten in Journal of physiological anthropology Kawaguchi : J-STAGE, 2006 33(2014), 1 vom: 03. Jan. (DE-627)516802429 (DE-600)2248082-1 1880-6805 nnns volume:33 year:2014 number:1 day:03 month:01 https://dx.doi.org/10.1186/1880-6805-33-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 33 2014 1 03 01
allfieldsGer	10.1186/1880-6805-33-1 doi (DE-627)SPR032853874 (SPR)1880-6805-33-1-e DE-627 ger DE-627 rakwb eng 610 ASE Kokaze, Akatsuki verfasserin aut Difference in effects of cigarette smoking or alcohol consumption on serum non-high-density lipoprotein cholesterol levels is related to mitochondrial DNA 5178 C/A polymorphism in middle-aged Japanese men: a cross-sectional study 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Mitochondrial DNA 5178 cytosine/adenosine (Mt5178 C/A) polymorphism is associated with longevity in the Japanese. The purpose of this study is to investigate whether Mt5178 C/A polymorphism modifies the effects of habitual smoking or habitual drinking on serum non-high-density lipoprotein (non-HDL) cholesterol levels in middle-aged Japanese men. Methods A total of 394 male subjects (age 53.9 ± 7.9 years; mean ± SD) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the joint effects of Mt5178 C/A polymorphism and cigarette smoking or alcohol drinking on serum non-HDL cholesterol levels was conducted. High levels of serum non-HDL cholesterol were defined as serum non-HDL cholesterol levels ≥160 mg/dl or ≥190 mg/dl. Results For men with Mt5178A, cigarette smoking may increase serum non-HDL cholesterol levels (P for trend < 0.001), as well as the risk of high levels of non-HDL cholesterol (serum non-HDL cholesterol levels ≥160 mg/dl, P for trend < 0.001; serum non-HDL cholesterol levels ≥190 mg/dl, P for trend = 0.004). On the other hand, for men with Mt5178C, after adjusting for age and body mass index, alcohol consumption may decrease serum non-HDL cholesterol levels (P for trend = 0.043) and the risk of high levels of non-HDL cholesterol (serum non-HDL cholesterol level ≥160 mg/dl, P for trend = 0.005). Conclusions These gene-environment interactions on serum non-HDL cholesterol levels may contribute to the establishment of individualized prevention of the risk of high levels of serum non-HDL cholesterol. Alcohol consumption (dpeaa)DE-He213 Cigarette smoking (dpeaa)DE-He213 Longevity (dpeaa)DE-He213 Mitochondrial DNA polymorphism (dpeaa)DE-He213 Non-HDL cholesterol (dpeaa)DE-He213 Ishikawa, Mamoru verfasserin aut Matsunaga, Naomi verfasserin aut Karita, Kanae verfasserin aut Yoshida, Masao verfasserin aut Ohtsu, Tadahiro verfasserin aut Ochiai, Hirotaka verfasserin aut Shirasawa, Takako verfasserin aut Nanri, Hinako verfasserin aut Hoshino, Hiromi verfasserin aut Takashima, Yutaka verfasserin aut Enthalten in Journal of physiological anthropology Kawaguchi : J-STAGE, 2006 33(2014), 1 vom: 03. Jan. (DE-627)516802429 (DE-600)2248082-1 1880-6805 nnns volume:33 year:2014 number:1 day:03 month:01 https://dx.doi.org/10.1186/1880-6805-33-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 33 2014 1 03 01
allfieldsSound	10.1186/1880-6805-33-1 doi (DE-627)SPR032853874 (SPR)1880-6805-33-1-e DE-627 ger DE-627 rakwb eng 610 ASE Kokaze, Akatsuki verfasserin aut Difference in effects of cigarette smoking or alcohol consumption on serum non-high-density lipoprotein cholesterol levels is related to mitochondrial DNA 5178 C/A polymorphism in middle-aged Japanese men: a cross-sectional study 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Mitochondrial DNA 5178 cytosine/adenosine (Mt5178 C/A) polymorphism is associated with longevity in the Japanese. The purpose of this study is to investigate whether Mt5178 C/A polymorphism modifies the effects of habitual smoking or habitual drinking on serum non-high-density lipoprotein (non-HDL) cholesterol levels in middle-aged Japanese men. Methods A total of 394 male subjects (age 53.9 ± 7.9 years; mean ± SD) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the joint effects of Mt5178 C/A polymorphism and cigarette smoking or alcohol drinking on serum non-HDL cholesterol levels was conducted. High levels of serum non-HDL cholesterol were defined as serum non-HDL cholesterol levels ≥160 mg/dl or ≥190 mg/dl. Results For men with Mt5178A, cigarette smoking may increase serum non-HDL cholesterol levels (P for trend < 0.001), as well as the risk of high levels of non-HDL cholesterol (serum non-HDL cholesterol levels ≥160 mg/dl, P for trend < 0.001; serum non-HDL cholesterol levels ≥190 mg/dl, P for trend = 0.004). On the other hand, for men with Mt5178C, after adjusting for age and body mass index, alcohol consumption may decrease serum non-HDL cholesterol levels (P for trend = 0.043) and the risk of high levels of non-HDL cholesterol (serum non-HDL cholesterol level ≥160 mg/dl, P for trend = 0.005). Conclusions These gene-environment interactions on serum non-HDL cholesterol levels may contribute to the establishment of individualized prevention of the risk of high levels of serum non-HDL cholesterol. Alcohol consumption (dpeaa)DE-He213 Cigarette smoking (dpeaa)DE-He213 Longevity (dpeaa)DE-He213 Mitochondrial DNA polymorphism (dpeaa)DE-He213 Non-HDL cholesterol (dpeaa)DE-He213 Ishikawa, Mamoru verfasserin aut Matsunaga, Naomi verfasserin aut Karita, Kanae verfasserin aut Yoshida, Masao verfasserin aut Ohtsu, Tadahiro verfasserin aut Ochiai, Hirotaka verfasserin aut Shirasawa, Takako verfasserin aut Nanri, Hinako verfasserin aut Hoshino, Hiromi verfasserin aut Takashima, Yutaka verfasserin aut Enthalten in Journal of physiological anthropology Kawaguchi : J-STAGE, 2006 33(2014), 1 vom: 03. Jan. (DE-627)516802429 (DE-600)2248082-1 1880-6805 nnns volume:33 year:2014 number:1 day:03 month:01 https://dx.doi.org/10.1186/1880-6805-33-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 33 2014 1 03 01
language	English
source	Enthalten in Journal of physiological anthropology 33(2014), 1 vom: 03. Jan. volume:33 year:2014 number:1 day:03 month:01
sourceStr	Enthalten in Journal of physiological anthropology 33(2014), 1 vom: 03. Jan. volume:33 year:2014 number:1 day:03 month:01
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Alcohol consumption Cigarette smoking Longevity Mitochondrial DNA polymorphism Non-HDL cholesterol
dewey-raw	610
isfreeaccess_bool	true
container_title	Journal of physiological anthropology
authorswithroles_txt_mv	Kokaze, Akatsuki @@aut@@ Ishikawa, Mamoru @@aut@@ Matsunaga, Naomi @@aut@@ Karita, Kanae @@aut@@ Yoshida, Masao @@aut@@ Ohtsu, Tadahiro @@aut@@ Ochiai, Hirotaka @@aut@@ Shirasawa, Takako @@aut@@ Nanri, Hinako @@aut@@ Hoshino, Hiromi @@aut@@ Takashima, Yutaka @@aut@@
publishDateDaySort_date	2014-01-03T00:00:00Z
hierarchy_top_id	516802429
dewey-sort	3610
id	SPR032853874
language_de	englisch
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The purpose of this study is to investigate whether Mt5178 C/A polymorphism modifies the effects of habitual smoking or habitual drinking on serum non-high-density lipoprotein (non-HDL) cholesterol levels in middle-aged Japanese men. Methods A total of 394 male subjects (age 53.9 ± 7.9 years; mean ± SD) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the joint effects of Mt5178 C/A polymorphism and cigarette smoking or alcohol drinking on serum non-HDL cholesterol levels was conducted. High levels of serum non-HDL cholesterol were defined as serum non-HDL cholesterol levels ≥160 mg/dl or ≥190 mg/dl. Results For men with Mt5178A, cigarette smoking may increase serum non-HDL cholesterol levels (P for trend < 0.001), as well as the risk of high levels of non-HDL cholesterol (serum non-HDL cholesterol levels ≥160 mg/dl, P for trend < 0.001; serum non-HDL cholesterol levels ≥190 mg/dl, P for trend = 0.004). On the other hand, for men with Mt5178C, after adjusting for age and body mass index, alcohol consumption may decrease serum non-HDL cholesterol levels (P for trend = 0.043) and the risk of high levels of non-HDL cholesterol (serum non-HDL cholesterol level ≥160 mg/dl, P for trend = 0.005). 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author	Kokaze, Akatsuki
spellingShingle	Kokaze, Akatsuki ddc 610 misc Alcohol consumption misc Cigarette smoking misc Longevity misc Mitochondrial DNA polymorphism misc Non-HDL cholesterol Difference in effects of cigarette smoking or alcohol consumption on serum non-high-density lipoprotein cholesterol levels is related to mitochondrial DNA 5178 C/A polymorphism in middle-aged Japanese men: a cross-sectional study
authorStr	Kokaze, Akatsuki
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topic_title	610 ASE Difference in effects of cigarette smoking or alcohol consumption on serum non-high-density lipoprotein cholesterol levels is related to mitochondrial DNA 5178 C/A polymorphism in middle-aged Japanese men: a cross-sectional study Alcohol consumption (dpeaa)DE-He213 Cigarette smoking (dpeaa)DE-He213 Longevity (dpeaa)DE-He213 Mitochondrial DNA polymorphism (dpeaa)DE-He213 Non-HDL cholesterol (dpeaa)DE-He213
topic	ddc 610 misc Alcohol consumption misc Cigarette smoking misc Longevity misc Mitochondrial DNA polymorphism misc Non-HDL cholesterol
topic_unstemmed	ddc 610 misc Alcohol consumption misc Cigarette smoking misc Longevity misc Mitochondrial DNA polymorphism misc Non-HDL cholesterol
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title	Difference in effects of cigarette smoking or alcohol consumption on serum non-high-density lipoprotein cholesterol levels is related to mitochondrial DNA 5178 C/A polymorphism in middle-aged Japanese men: a cross-sectional study
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title_full	Difference in effects of cigarette smoking or alcohol consumption on serum non-high-density lipoprotein cholesterol levels is related to mitochondrial DNA 5178 C/A polymorphism in middle-aged Japanese men: a cross-sectional study
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author_browse	Kokaze, Akatsuki Ishikawa, Mamoru Matsunaga, Naomi Karita, Kanae Yoshida, Masao Ohtsu, Tadahiro Ochiai, Hirotaka Shirasawa, Takako Nanri, Hinako Hoshino, Hiromi Takashima, Yutaka
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title_sort	difference in effects of cigarette smoking or alcohol consumption on serum non-high-density lipoprotein cholesterol levels is related to mitochondrial dna 5178 c/a polymorphism in middle-aged japanese men: a cross-sectional study
title_auth	Difference in effects of cigarette smoking or alcohol consumption on serum non-high-density lipoprotein cholesterol levels is related to mitochondrial DNA 5178 C/A polymorphism in middle-aged Japanese men: a cross-sectional study
abstract	Background Mitochondrial DNA 5178 cytosine/adenosine (Mt5178 C/A) polymorphism is associated with longevity in the Japanese. The purpose of this study is to investigate whether Mt5178 C/A polymorphism modifies the effects of habitual smoking or habitual drinking on serum non-high-density lipoprotein (non-HDL) cholesterol levels in middle-aged Japanese men. Methods A total of 394 male subjects (age 53.9 ± 7.9 years; mean ± SD) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the joint effects of Mt5178 C/A polymorphism and cigarette smoking or alcohol drinking on serum non-HDL cholesterol levels was conducted. High levels of serum non-HDL cholesterol were defined as serum non-HDL cholesterol levels ≥160 mg/dl or ≥190 mg/dl. Results For men with Mt5178A, cigarette smoking may increase serum non-HDL cholesterol levels (P for trend < 0.001), as well as the risk of high levels of non-HDL cholesterol (serum non-HDL cholesterol levels ≥160 mg/dl, P for trend < 0.001; serum non-HDL cholesterol levels ≥190 mg/dl, P for trend = 0.004). On the other hand, for men with Mt5178C, after adjusting for age and body mass index, alcohol consumption may decrease serum non-HDL cholesterol levels (P for trend = 0.043) and the risk of high levels of non-HDL cholesterol (serum non-HDL cholesterol level ≥160 mg/dl, P for trend = 0.005). Conclusions These gene-environment interactions on serum non-HDL cholesterol levels may contribute to the establishment of individualized prevention of the risk of high levels of serum non-HDL cholesterol.
abstractGer	Background Mitochondrial DNA 5178 cytosine/adenosine (Mt5178 C/A) polymorphism is associated with longevity in the Japanese. The purpose of this study is to investigate whether Mt5178 C/A polymorphism modifies the effects of habitual smoking or habitual drinking on serum non-high-density lipoprotein (non-HDL) cholesterol levels in middle-aged Japanese men. Methods A total of 394 male subjects (age 53.9 ± 7.9 years; mean ± SD) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the joint effects of Mt5178 C/A polymorphism and cigarette smoking or alcohol drinking on serum non-HDL cholesterol levels was conducted. High levels of serum non-HDL cholesterol were defined as serum non-HDL cholesterol levels ≥160 mg/dl or ≥190 mg/dl. Results For men with Mt5178A, cigarette smoking may increase serum non-HDL cholesterol levels (P for trend < 0.001), as well as the risk of high levels of non-HDL cholesterol (serum non-HDL cholesterol levels ≥160 mg/dl, P for trend < 0.001; serum non-HDL cholesterol levels ≥190 mg/dl, P for trend = 0.004). On the other hand, for men with Mt5178C, after adjusting for age and body mass index, alcohol consumption may decrease serum non-HDL cholesterol levels (P for trend = 0.043) and the risk of high levels of non-HDL cholesterol (serum non-HDL cholesterol level ≥160 mg/dl, P for trend = 0.005). Conclusions These gene-environment interactions on serum non-HDL cholesterol levels may contribute to the establishment of individualized prevention of the risk of high levels of serum non-HDL cholesterol.
abstract_unstemmed	Background Mitochondrial DNA 5178 cytosine/adenosine (Mt5178 C/A) polymorphism is associated with longevity in the Japanese. The purpose of this study is to investigate whether Mt5178 C/A polymorphism modifies the effects of habitual smoking or habitual drinking on serum non-high-density lipoprotein (non-HDL) cholesterol levels in middle-aged Japanese men. Methods A total of 394 male subjects (age 53.9 ± 7.9 years; mean ± SD) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the joint effects of Mt5178 C/A polymorphism and cigarette smoking or alcohol drinking on serum non-HDL cholesterol levels was conducted. High levels of serum non-HDL cholesterol were defined as serum non-HDL cholesterol levels ≥160 mg/dl or ≥190 mg/dl. Results For men with Mt5178A, cigarette smoking may increase serum non-HDL cholesterol levels (P for trend < 0.001), as well as the risk of high levels of non-HDL cholesterol (serum non-HDL cholesterol levels ≥160 mg/dl, P for trend < 0.001; serum non-HDL cholesterol levels ≥190 mg/dl, P for trend = 0.004). On the other hand, for men with Mt5178C, after adjusting for age and body mass index, alcohol consumption may decrease serum non-HDL cholesterol levels (P for trend = 0.043) and the risk of high levels of non-HDL cholesterol (serum non-HDL cholesterol level ≥160 mg/dl, P for trend = 0.005). Conclusions These gene-environment interactions on serum non-HDL cholesterol levels may contribute to the establishment of individualized prevention of the risk of high levels of serum non-HDL cholesterol.
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title_short	Difference in effects of cigarette smoking or alcohol consumption on serum non-high-density lipoprotein cholesterol levels is related to mitochondrial DNA 5178 C/A polymorphism in middle-aged Japanese men: a cross-sectional study
url	https://dx.doi.org/10.1186/1880-6805-33-1
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author2	Ishikawa, Mamoru Matsunaga, Naomi Karita, Kanae Yoshida, Masao Ohtsu, Tadahiro Ochiai, Hirotaka Shirasawa, Takako Nanri, Hinako Hoshino, Hiromi Takashima, Yutaka
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The purpose of this study is to investigate whether Mt5178 C/A polymorphism modifies the effects of habitual smoking or habitual drinking on serum non-high-density lipoprotein (non-HDL) cholesterol levels in middle-aged Japanese men. Methods A total of 394 male subjects (age 53.9 ± 7.9 years; mean ± SD) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the joint effects of Mt5178 C/A polymorphism and cigarette smoking or alcohol drinking on serum non-HDL cholesterol levels was conducted. High levels of serum non-HDL cholesterol were defined as serum non-HDL cholesterol levels ≥160 mg/dl or ≥190 mg/dl. 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Difference in effects of cigarette smoking or alcohol consumption on serum non-high-density lipoprotein cholesterol levels is related to mitochondrial DNA 5178 C/A polymorphism in middle-aged Japanese men: a cross-sectional study

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