Defining the Incidence and Associated Morbidity and Mortality of Severe Respiratory Syncytial Virus Infection Among Children with Chronic Diseases

Introduction REGAL (RSV Evidence—a Geographical Archive of the Literature) has provided a comprehensive review of the published evidence in the field of respiratory syncytial virus (RSV) in Western countries over the last 20 years. This review covers the risk and burden of RSV infection in children...
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Autor*in:	Manzoni, Paolo [verfasserIn] Figueras-Aloy, Josep [verfasserIn] Simões, Eric A. F. [verfasserIn] Checchia, Paul A. [verfasserIn] Fauroux, Brigitte [verfasserIn] Bont, Louis [verfasserIn] Paes, Bosco [verfasserIn] Carbonell-Estrany, Xavier [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	Bronchiolitis Comorbidity Congenital malformation Cystic fibrosis Down syndrome Immunocompromised Neuromuscular impairment Outcomes Respiratory syncytial virus lower respiratory tract infection Transplant

Übergeordnetes Werk:	Enthalten in: Infectious diseases and therapy - Heidelberg : Springer, 2012, 6(2017), 3 vom: 26. Juni, Seite 383-411
Übergeordnetes Werk:	volume:6 ; year:2017 ; number:3 ; day:26 ; month:06 ; pages:383-411

Links:	Volltext

DOI / URN:	10.1007/s40121-017-0160-3

Katalog-ID:	SPR032879881

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520			\|a Introduction REGAL (RSV Evidence—a Geographical Archive of the Literature) has provided a comprehensive review of the published evidence in the field of respiratory syncytial virus (RSV) in Western countries over the last 20 years. This review covers the risk and burden of RSV infection in children with underlying medical conditions or chronic diseases (excluding prematurity and congenital heart disease). Methods A systematic review of publications between January 1, 1995 and December 31, 2015 across PubMed, Embase, The Cochrane Library, and Clinicaltrials.gov was supplemented by papers identified by the authors through March 2017. Studies reporting data for hospital visits/admissions for RSV infection as well as studies reporting RSV-associated morbidity and mortality were included. Study quality and strength of evidence (SOE) were graded. Results A total of 2703 studies were identified and 58 were included. Down syndrome, irrespective of prematurity and congenital heart disease (moderate SOE), immunocompromised children (low SOE), cystic fibrosis (low SOE), and neurologic conditions (low SOE) were associated with a significantly increased risk of RSV hospitalization. A number of other congenital malformations and chronic conditions were also associated with severe RSV disease (low SOE). In general, pre-existing disease was also a predisposing factor for RSV-related mortality (low SOE). Conclusion Severe RSV infection in infants and young children with underlying medical conditions or chronic diseases poses a significant health burden. Further studies are needed to fully quantify the epidemiology, burden and outcomes in these populations, in particular RSV-attributable mortality.
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allfields	10.1007/s40121-017-0160-3 doi (DE-627)SPR032879881 (SPR)s40121-017-0160-3-e DE-627 ger DE-627 rakwb eng 610 ASE Manzoni, Paolo verfasserin aut Defining the Incidence and Associated Morbidity and Mortality of Severe Respiratory Syncytial Virus Infection Among Children with Chronic Diseases 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction REGAL (RSV Evidence—a Geographical Archive of the Literature) has provided a comprehensive review of the published evidence in the field of respiratory syncytial virus (RSV) in Western countries over the last 20 years. This review covers the risk and burden of RSV infection in children with underlying medical conditions or chronic diseases (excluding prematurity and congenital heart disease). Methods A systematic review of publications between January 1, 1995 and December 31, 2015 across PubMed, Embase, The Cochrane Library, and Clinicaltrials.gov was supplemented by papers identified by the authors through March 2017. Studies reporting data for hospital visits/admissions for RSV infection as well as studies reporting RSV-associated morbidity and mortality were included. Study quality and strength of evidence (SOE) were graded. Results A total of 2703 studies were identified and 58 were included. Down syndrome, irrespective of prematurity and congenital heart disease (moderate SOE), immunocompromised children (low SOE), cystic fibrosis (low SOE), and neurologic conditions (low SOE) were associated with a significantly increased risk of RSV hospitalization. A number of other congenital malformations and chronic conditions were also associated with severe RSV disease (low SOE). In general, pre-existing disease was also a predisposing factor for RSV-related mortality (low SOE). Conclusion Severe RSV infection in infants and young children with underlying medical conditions or chronic diseases poses a significant health burden. Further studies are needed to fully quantify the epidemiology, burden and outcomes in these populations, in particular RSV-attributable mortality. Bronchiolitis (dpeaa)DE-He213 Comorbidity (dpeaa)DE-He213 Congenital malformation (dpeaa)DE-He213 Cystic fibrosis (dpeaa)DE-He213 Down syndrome (dpeaa)DE-He213 Immunocompromised (dpeaa)DE-He213 Neuromuscular impairment (dpeaa)DE-He213 Outcomes (dpeaa)DE-He213 Respiratory syncytial virus lower respiratory tract infection (dpeaa)DE-He213 Transplant (dpeaa)DE-He213 Figueras-Aloy, Josep verfasserin aut Simões, Eric A. F. verfasserin aut Checchia, Paul A. verfasserin aut Fauroux, Brigitte verfasserin aut Bont, Louis verfasserin aut Paes, Bosco verfasserin aut Carbonell-Estrany, Xavier verfasserin aut Enthalten in Infectious diseases and therapy Heidelberg : Springer, 2012 6(2017), 3 vom: 26. Juni, Seite 383-411 (DE-627)735690766 (DE-600)2701611-0 2193-6382 nnns volume:6 year:2017 number:3 day:26 month:06 pages:383-411 https://dx.doi.org/10.1007/s40121-017-0160-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2017 3 26 06 383-411
spelling	10.1007/s40121-017-0160-3 doi (DE-627)SPR032879881 (SPR)s40121-017-0160-3-e DE-627 ger DE-627 rakwb eng 610 ASE Manzoni, Paolo verfasserin aut Defining the Incidence and Associated Morbidity and Mortality of Severe Respiratory Syncytial Virus Infection Among Children with Chronic Diseases 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction REGAL (RSV Evidence—a Geographical Archive of the Literature) has provided a comprehensive review of the published evidence in the field of respiratory syncytial virus (RSV) in Western countries over the last 20 years. This review covers the risk and burden of RSV infection in children with underlying medical conditions or chronic diseases (excluding prematurity and congenital heart disease). Methods A systematic review of publications between January 1, 1995 and December 31, 2015 across PubMed, Embase, The Cochrane Library, and Clinicaltrials.gov was supplemented by papers identified by the authors through March 2017. Studies reporting data for hospital visits/admissions for RSV infection as well as studies reporting RSV-associated morbidity and mortality were included. Study quality and strength of evidence (SOE) were graded. Results A total of 2703 studies were identified and 58 were included. Down syndrome, irrespective of prematurity and congenital heart disease (moderate SOE), immunocompromised children (low SOE), cystic fibrosis (low SOE), and neurologic conditions (low SOE) were associated with a significantly increased risk of RSV hospitalization. A number of other congenital malformations and chronic conditions were also associated with severe RSV disease (low SOE). In general, pre-existing disease was also a predisposing factor for RSV-related mortality (low SOE). Conclusion Severe RSV infection in infants and young children with underlying medical conditions or chronic diseases poses a significant health burden. Further studies are needed to fully quantify the epidemiology, burden and outcomes in these populations, in particular RSV-attributable mortality. Bronchiolitis (dpeaa)DE-He213 Comorbidity (dpeaa)DE-He213 Congenital malformation (dpeaa)DE-He213 Cystic fibrosis (dpeaa)DE-He213 Down syndrome (dpeaa)DE-He213 Immunocompromised (dpeaa)DE-He213 Neuromuscular impairment (dpeaa)DE-He213 Outcomes (dpeaa)DE-He213 Respiratory syncytial virus lower respiratory tract infection (dpeaa)DE-He213 Transplant (dpeaa)DE-He213 Figueras-Aloy, Josep verfasserin aut Simões, Eric A. F. verfasserin aut Checchia, Paul A. verfasserin aut Fauroux, Brigitte verfasserin aut Bont, Louis verfasserin aut Paes, Bosco verfasserin aut Carbonell-Estrany, Xavier verfasserin aut Enthalten in Infectious diseases and therapy Heidelberg : Springer, 2012 6(2017), 3 vom: 26. Juni, Seite 383-411 (DE-627)735690766 (DE-600)2701611-0 2193-6382 nnns volume:6 year:2017 number:3 day:26 month:06 pages:383-411 https://dx.doi.org/10.1007/s40121-017-0160-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2017 3 26 06 383-411
allfields_unstemmed	10.1007/s40121-017-0160-3 doi (DE-627)SPR032879881 (SPR)s40121-017-0160-3-e DE-627 ger DE-627 rakwb eng 610 ASE Manzoni, Paolo verfasserin aut Defining the Incidence and Associated Morbidity and Mortality of Severe Respiratory Syncytial Virus Infection Among Children with Chronic Diseases 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction REGAL (RSV Evidence—a Geographical Archive of the Literature) has provided a comprehensive review of the published evidence in the field of respiratory syncytial virus (RSV) in Western countries over the last 20 years. This review covers the risk and burden of RSV infection in children with underlying medical conditions or chronic diseases (excluding prematurity and congenital heart disease). Methods A systematic review of publications between January 1, 1995 and December 31, 2015 across PubMed, Embase, The Cochrane Library, and Clinicaltrials.gov was supplemented by papers identified by the authors through March 2017. Studies reporting data for hospital visits/admissions for RSV infection as well as studies reporting RSV-associated morbidity and mortality were included. Study quality and strength of evidence (SOE) were graded. Results A total of 2703 studies were identified and 58 were included. Down syndrome, irrespective of prematurity and congenital heart disease (moderate SOE), immunocompromised children (low SOE), cystic fibrosis (low SOE), and neurologic conditions (low SOE) were associated with a significantly increased risk of RSV hospitalization. A number of other congenital malformations and chronic conditions were also associated with severe RSV disease (low SOE). In general, pre-existing disease was also a predisposing factor for RSV-related mortality (low SOE). Conclusion Severe RSV infection in infants and young children with underlying medical conditions or chronic diseases poses a significant health burden. Further studies are needed to fully quantify the epidemiology, burden and outcomes in these populations, in particular RSV-attributable mortality. Bronchiolitis (dpeaa)DE-He213 Comorbidity (dpeaa)DE-He213 Congenital malformation (dpeaa)DE-He213 Cystic fibrosis (dpeaa)DE-He213 Down syndrome (dpeaa)DE-He213 Immunocompromised (dpeaa)DE-He213 Neuromuscular impairment (dpeaa)DE-He213 Outcomes (dpeaa)DE-He213 Respiratory syncytial virus lower respiratory tract infection (dpeaa)DE-He213 Transplant (dpeaa)DE-He213 Figueras-Aloy, Josep verfasserin aut Simões, Eric A. F. verfasserin aut Checchia, Paul A. verfasserin aut Fauroux, Brigitte verfasserin aut Bont, Louis verfasserin aut Paes, Bosco verfasserin aut Carbonell-Estrany, Xavier verfasserin aut Enthalten in Infectious diseases and therapy Heidelberg : Springer, 2012 6(2017), 3 vom: 26. Juni, Seite 383-411 (DE-627)735690766 (DE-600)2701611-0 2193-6382 nnns volume:6 year:2017 number:3 day:26 month:06 pages:383-411 https://dx.doi.org/10.1007/s40121-017-0160-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2017 3 26 06 383-411
allfieldsGer	10.1007/s40121-017-0160-3 doi (DE-627)SPR032879881 (SPR)s40121-017-0160-3-e DE-627 ger DE-627 rakwb eng 610 ASE Manzoni, Paolo verfasserin aut Defining the Incidence and Associated Morbidity and Mortality of Severe Respiratory Syncytial Virus Infection Among Children with Chronic Diseases 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction REGAL (RSV Evidence—a Geographical Archive of the Literature) has provided a comprehensive review of the published evidence in the field of respiratory syncytial virus (RSV) in Western countries over the last 20 years. This review covers the risk and burden of RSV infection in children with underlying medical conditions or chronic diseases (excluding prematurity and congenital heart disease). Methods A systematic review of publications between January 1, 1995 and December 31, 2015 across PubMed, Embase, The Cochrane Library, and Clinicaltrials.gov was supplemented by papers identified by the authors through March 2017. Studies reporting data for hospital visits/admissions for RSV infection as well as studies reporting RSV-associated morbidity and mortality were included. Study quality and strength of evidence (SOE) were graded. Results A total of 2703 studies were identified and 58 were included. Down syndrome, irrespective of prematurity and congenital heart disease (moderate SOE), immunocompromised children (low SOE), cystic fibrosis (low SOE), and neurologic conditions (low SOE) were associated with a significantly increased risk of RSV hospitalization. A number of other congenital malformations and chronic conditions were also associated with severe RSV disease (low SOE). In general, pre-existing disease was also a predisposing factor for RSV-related mortality (low SOE). Conclusion Severe RSV infection in infants and young children with underlying medical conditions or chronic diseases poses a significant health burden. Further studies are needed to fully quantify the epidemiology, burden and outcomes in these populations, in particular RSV-attributable mortality. Bronchiolitis (dpeaa)DE-He213 Comorbidity (dpeaa)DE-He213 Congenital malformation (dpeaa)DE-He213 Cystic fibrosis (dpeaa)DE-He213 Down syndrome (dpeaa)DE-He213 Immunocompromised (dpeaa)DE-He213 Neuromuscular impairment (dpeaa)DE-He213 Outcomes (dpeaa)DE-He213 Respiratory syncytial virus lower respiratory tract infection (dpeaa)DE-He213 Transplant (dpeaa)DE-He213 Figueras-Aloy, Josep verfasserin aut Simões, Eric A. F. verfasserin aut Checchia, Paul A. verfasserin aut Fauroux, Brigitte verfasserin aut Bont, Louis verfasserin aut Paes, Bosco verfasserin aut Carbonell-Estrany, Xavier verfasserin aut Enthalten in Infectious diseases and therapy Heidelberg : Springer, 2012 6(2017), 3 vom: 26. Juni, Seite 383-411 (DE-627)735690766 (DE-600)2701611-0 2193-6382 nnns volume:6 year:2017 number:3 day:26 month:06 pages:383-411 https://dx.doi.org/10.1007/s40121-017-0160-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2017 3 26 06 383-411
allfieldsSound	10.1007/s40121-017-0160-3 doi (DE-627)SPR032879881 (SPR)s40121-017-0160-3-e DE-627 ger DE-627 rakwb eng 610 ASE Manzoni, Paolo verfasserin aut Defining the Incidence and Associated Morbidity and Mortality of Severe Respiratory Syncytial Virus Infection Among Children with Chronic Diseases 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction REGAL (RSV Evidence—a Geographical Archive of the Literature) has provided a comprehensive review of the published evidence in the field of respiratory syncytial virus (RSV) in Western countries over the last 20 years. This review covers the risk and burden of RSV infection in children with underlying medical conditions or chronic diseases (excluding prematurity and congenital heart disease). Methods A systematic review of publications between January 1, 1995 and December 31, 2015 across PubMed, Embase, The Cochrane Library, and Clinicaltrials.gov was supplemented by papers identified by the authors through March 2017. Studies reporting data for hospital visits/admissions for RSV infection as well as studies reporting RSV-associated morbidity and mortality were included. Study quality and strength of evidence (SOE) were graded. Results A total of 2703 studies were identified and 58 were included. Down syndrome, irrespective of prematurity and congenital heart disease (moderate SOE), immunocompromised children (low SOE), cystic fibrosis (low SOE), and neurologic conditions (low SOE) were associated with a significantly increased risk of RSV hospitalization. A number of other congenital malformations and chronic conditions were also associated with severe RSV disease (low SOE). In general, pre-existing disease was also a predisposing factor for RSV-related mortality (low SOE). Conclusion Severe RSV infection in infants and young children with underlying medical conditions or chronic diseases poses a significant health burden. Further studies are needed to fully quantify the epidemiology, burden and outcomes in these populations, in particular RSV-attributable mortality. Bronchiolitis (dpeaa)DE-He213 Comorbidity (dpeaa)DE-He213 Congenital malformation (dpeaa)DE-He213 Cystic fibrosis (dpeaa)DE-He213 Down syndrome (dpeaa)DE-He213 Immunocompromised (dpeaa)DE-He213 Neuromuscular impairment (dpeaa)DE-He213 Outcomes (dpeaa)DE-He213 Respiratory syncytial virus lower respiratory tract infection (dpeaa)DE-He213 Transplant (dpeaa)DE-He213 Figueras-Aloy, Josep verfasserin aut Simões, Eric A. F. verfasserin aut Checchia, Paul A. verfasserin aut Fauroux, Brigitte verfasserin aut Bont, Louis verfasserin aut Paes, Bosco verfasserin aut Carbonell-Estrany, Xavier verfasserin aut Enthalten in Infectious diseases and therapy Heidelberg : Springer, 2012 6(2017), 3 vom: 26. Juni, Seite 383-411 (DE-627)735690766 (DE-600)2701611-0 2193-6382 nnns volume:6 year:2017 number:3 day:26 month:06 pages:383-411 https://dx.doi.org/10.1007/s40121-017-0160-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2017 3 26 06 383-411
language	English
source	Enthalten in Infectious diseases and therapy 6(2017), 3 vom: 26. Juni, Seite 383-411 volume:6 year:2017 number:3 day:26 month:06 pages:383-411
sourceStr	Enthalten in Infectious diseases and therapy 6(2017), 3 vom: 26. Juni, Seite 383-411 volume:6 year:2017 number:3 day:26 month:06 pages:383-411
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Bronchiolitis Comorbidity Congenital malformation Cystic fibrosis Down syndrome Immunocompromised Neuromuscular impairment Outcomes Respiratory syncytial virus lower respiratory tract infection Transplant
dewey-raw	610
isfreeaccess_bool	true
container_title	Infectious diseases and therapy
authorswithroles_txt_mv	Manzoni, Paolo @@aut@@ Figueras-Aloy, Josep @@aut@@ Simões, Eric A. F. @@aut@@ Checchia, Paul A. @@aut@@ Fauroux, Brigitte @@aut@@ Bont, Louis @@aut@@ Paes, Bosco @@aut@@ Carbonell-Estrany, Xavier @@aut@@
publishDateDaySort_date	2017-06-26T00:00:00Z
hierarchy_top_id	735690766
dewey-sort	3610
id	SPR032879881
language_de	englisch
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A number of other congenital malformations and chronic conditions were also associated with severe RSV disease (low SOE). In general, pre-existing disease was also a predisposing factor for RSV-related mortality (low SOE). Conclusion Severe RSV infection in infants and young children with underlying medical conditions or chronic diseases poses a significant health burden. 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author	Manzoni, Paolo
spellingShingle	Manzoni, Paolo ddc 610 misc Bronchiolitis misc Comorbidity misc Congenital malformation misc Cystic fibrosis misc Down syndrome misc Immunocompromised misc Neuromuscular impairment misc Outcomes misc Respiratory syncytial virus lower respiratory tract infection misc Transplant Defining the Incidence and Associated Morbidity and Mortality of Severe Respiratory Syncytial Virus Infection Among Children with Chronic Diseases
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topic_title	610 ASE Defining the Incidence and Associated Morbidity and Mortality of Severe Respiratory Syncytial Virus Infection Among Children with Chronic Diseases Bronchiolitis (dpeaa)DE-He213 Comorbidity (dpeaa)DE-He213 Congenital malformation (dpeaa)DE-He213 Cystic fibrosis (dpeaa)DE-He213 Down syndrome (dpeaa)DE-He213 Immunocompromised (dpeaa)DE-He213 Neuromuscular impairment (dpeaa)DE-He213 Outcomes (dpeaa)DE-He213 Respiratory syncytial virus lower respiratory tract infection (dpeaa)DE-He213 Transplant (dpeaa)DE-He213
topic	ddc 610 misc Bronchiolitis misc Comorbidity misc Congenital malformation misc Cystic fibrosis misc Down syndrome misc Immunocompromised misc Neuromuscular impairment misc Outcomes misc Respiratory syncytial virus lower respiratory tract infection misc Transplant
topic_unstemmed	ddc 610 misc Bronchiolitis misc Comorbidity misc Congenital malformation misc Cystic fibrosis misc Down syndrome misc Immunocompromised misc Neuromuscular impairment misc Outcomes misc Respiratory syncytial virus lower respiratory tract infection misc Transplant
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title	Defining the Incidence and Associated Morbidity and Mortality of Severe Respiratory Syncytial Virus Infection Among Children with Chronic Diseases
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title_full	Defining the Incidence and Associated Morbidity and Mortality of Severe Respiratory Syncytial Virus Infection Among Children with Chronic Diseases
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author_browse	Manzoni, Paolo Figueras-Aloy, Josep Simões, Eric A. F. Checchia, Paul A. Fauroux, Brigitte Bont, Louis Paes, Bosco Carbonell-Estrany, Xavier
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title_sort	defining the incidence and associated morbidity and mortality of severe respiratory syncytial virus infection among children with chronic diseases
title_auth	Defining the Incidence and Associated Morbidity and Mortality of Severe Respiratory Syncytial Virus Infection Among Children with Chronic Diseases
abstract	Introduction REGAL (RSV Evidence—a Geographical Archive of the Literature) has provided a comprehensive review of the published evidence in the field of respiratory syncytial virus (RSV) in Western countries over the last 20 years. This review covers the risk and burden of RSV infection in children with underlying medical conditions or chronic diseases (excluding prematurity and congenital heart disease). Methods A systematic review of publications between January 1, 1995 and December 31, 2015 across PubMed, Embase, The Cochrane Library, and Clinicaltrials.gov was supplemented by papers identified by the authors through March 2017. Studies reporting data for hospital visits/admissions for RSV infection as well as studies reporting RSV-associated morbidity and mortality were included. Study quality and strength of evidence (SOE) were graded. Results A total of 2703 studies were identified and 58 were included. Down syndrome, irrespective of prematurity and congenital heart disease (moderate SOE), immunocompromised children (low SOE), cystic fibrosis (low SOE), and neurologic conditions (low SOE) were associated with a significantly increased risk of RSV hospitalization. A number of other congenital malformations and chronic conditions were also associated with severe RSV disease (low SOE). In general, pre-existing disease was also a predisposing factor for RSV-related mortality (low SOE). Conclusion Severe RSV infection in infants and young children with underlying medical conditions or chronic diseases poses a significant health burden. Further studies are needed to fully quantify the epidemiology, burden and outcomes in these populations, in particular RSV-attributable mortality.
abstractGer	Introduction REGAL (RSV Evidence—a Geographical Archive of the Literature) has provided a comprehensive review of the published evidence in the field of respiratory syncytial virus (RSV) in Western countries over the last 20 years. This review covers the risk and burden of RSV infection in children with underlying medical conditions or chronic diseases (excluding prematurity and congenital heart disease). Methods A systematic review of publications between January 1, 1995 and December 31, 2015 across PubMed, Embase, The Cochrane Library, and Clinicaltrials.gov was supplemented by papers identified by the authors through March 2017. Studies reporting data for hospital visits/admissions for RSV infection as well as studies reporting RSV-associated morbidity and mortality were included. Study quality and strength of evidence (SOE) were graded. Results A total of 2703 studies were identified and 58 were included. Down syndrome, irrespective of prematurity and congenital heart disease (moderate SOE), immunocompromised children (low SOE), cystic fibrosis (low SOE), and neurologic conditions (low SOE) were associated with a significantly increased risk of RSV hospitalization. A number of other congenital malformations and chronic conditions were also associated with severe RSV disease (low SOE). In general, pre-existing disease was also a predisposing factor for RSV-related mortality (low SOE). Conclusion Severe RSV infection in infants and young children with underlying medical conditions or chronic diseases poses a significant health burden. Further studies are needed to fully quantify the epidemiology, burden and outcomes in these populations, in particular RSV-attributable mortality.
abstract_unstemmed	Introduction REGAL (RSV Evidence—a Geographical Archive of the Literature) has provided a comprehensive review of the published evidence in the field of respiratory syncytial virus (RSV) in Western countries over the last 20 years. This review covers the risk and burden of RSV infection in children with underlying medical conditions or chronic diseases (excluding prematurity and congenital heart disease). Methods A systematic review of publications between January 1, 1995 and December 31, 2015 across PubMed, Embase, The Cochrane Library, and Clinicaltrials.gov was supplemented by papers identified by the authors through March 2017. Studies reporting data for hospital visits/admissions for RSV infection as well as studies reporting RSV-associated morbidity and mortality were included. Study quality and strength of evidence (SOE) were graded. Results A total of 2703 studies were identified and 58 were included. Down syndrome, irrespective of prematurity and congenital heart disease (moderate SOE), immunocompromised children (low SOE), cystic fibrosis (low SOE), and neurologic conditions (low SOE) were associated with a significantly increased risk of RSV hospitalization. A number of other congenital malformations and chronic conditions were also associated with severe RSV disease (low SOE). In general, pre-existing disease was also a predisposing factor for RSV-related mortality (low SOE). Conclusion Severe RSV infection in infants and young children with underlying medical conditions or chronic diseases poses a significant health burden. Further studies are needed to fully quantify the epidemiology, burden and outcomes in these populations, in particular RSV-attributable mortality.
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title_short	Defining the Incidence and Associated Morbidity and Mortality of Severe Respiratory Syncytial Virus Infection Among Children with Chronic Diseases
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author2	Figueras-Aloy, Josep Simões, Eric A. F. Checchia, Paul A. Fauroux, Brigitte Bont, Louis Paes, Bosco Carbonell-Estrany, Xavier
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Defining the Incidence and Associated Morbidity and Mortality of Severe Respiratory Syncytial Virus Infection Among Children with Chronic Diseases

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