Conjugated polyelectrolyte-$ Ag^{+} $ fluorescent switch for biothiol sensing
Abstract A new “off-on” switch for sensitive and selective fluorescence detection of biothiols[glutathione(GSH), cysteine(Cys) and homocysteine(Hcy)] was developed based on an anionic conjugated polyelectrolyte(CPE), pyridyl-functionalized poly(phenylene ethynylene)(P1). The fluorescence of P1 can b...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Xiao, Yi [verfasserIn] Li, Sha [verfasserIn] Huang, Hong-mei [verfasserIn] Zhang, Ye [verfasserIn] Xue, Zun-zun [verfasserIn] Tang, Xue-yan [verfasserIn] He, Xiao-xiao [verfasserIn] Wang, Ke-min [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Chemical Research in Chinese Universities - Jilin University and The Editorial Department of Chemical Research in Chinese Universities, 2012, 29(2013), 5 vom: 06. Sept., Seite 845-849 |
|---|---|
| Übergeordnetes Werk: |
volume:29 ; year:2013 ; number:5 ; day:06 ; month:09 ; pages:845-849 |
| Links: |
|---|
| DOI / URN: |
10.1007/s40242-013-3180-x |
|---|
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SPR03290990X |
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| 520 | |a Abstract A new “off-on” switch for sensitive and selective fluorescence detection of biothiols[glutathione(GSH), cysteine(Cys) and homocysteine(Hcy)] was developed based on an anionic conjugated polyelectrolyte(CPE), pyridyl-functionalized poly(phenylene ethynylene)(P1). The fluorescence of P1 can be significantly quenched by $ Ag^{+} $ due to complexation-mediated interpolymer aggregation. Furthermore, biothiols can efficiently recover the fluorescence intensity of P1 as a result of the stronger binding between thiol group and $ Ag^{+} $, which dissociates P1 from the P1/$ Ag^{+} $ complex and disrupts interpolymer aggregation. Under optimum conditions, a good linear relationship in a range of 100–4200 nmol/L is obtained for GSH with a detection limit of 80 nmol/L(S/N=3). As a result of specific interaction between the thiol group and $ Ag^{+} $, the proposed method shows a high selectivity for biothiols. In addition, the CPE-based fluorescence “off-on” switch has been used to quantitatively detect total biothiols in cell lysates. | ||
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| 700 | 1 | |a Wang, Ke-min |e verfasserin |4 aut | |
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10.1007/s40242-013-3180-x doi (DE-627)SPR03290990X (SPR)s40242-013-3180-x-e DE-627 ger DE-627 rakwb eng Xiao, Yi verfasserin aut Conjugated polyelectrolyte-$ Ag^{+} $ fluorescent switch for biothiol sensing 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract A new “off-on” switch for sensitive and selective fluorescence detection of biothiols[glutathione(GSH), cysteine(Cys) and homocysteine(Hcy)] was developed based on an anionic conjugated polyelectrolyte(CPE), pyridyl-functionalized poly(phenylene ethynylene)(P1). The fluorescence of P1 can be significantly quenched by $ Ag^{+} $ due to complexation-mediated interpolymer aggregation. Furthermore, biothiols can efficiently recover the fluorescence intensity of P1 as a result of the stronger binding between thiol group and $ Ag^{+} $, which dissociates P1 from the P1/$ Ag^{+} $ complex and disrupts interpolymer aggregation. Under optimum conditions, a good linear relationship in a range of 100–4200 nmol/L is obtained for GSH with a detection limit of 80 nmol/L(S/N=3). As a result of specific interaction between the thiol group and $ Ag^{+} $, the proposed method shows a high selectivity for biothiols. In addition, the CPE-based fluorescence “off-on” switch has been used to quantitatively detect total biothiols in cell lysates. Fluorescent switch (dpeaa)DE-He213 Biothiol (dpeaa)DE-He213 Silver(I) (dpeaa)DE-He213 Conjugated polyelectrolyte (dpeaa)DE-He213 Li, Sha verfasserin aut Huang, Hong-mei verfasserin aut Zhang, Ye verfasserin aut Xue, Zun-zun verfasserin aut Tang, Xue-yan verfasserin aut He, Xiao-xiao verfasserin aut Wang, Ke-min verfasserin aut Enthalten in Chemical Research in Chinese Universities Jilin University and The Editorial Department of Chemical Research in Chinese Universities, 2012 29(2013), 5 vom: 06. Sept., Seite 845-849 (DE-627)SPR03290777X nnns volume:29 year:2013 number:5 day:06 month:09 pages:845-849 https://dx.doi.org/10.1007/s40242-013-3180-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 29 2013 5 06 09 845-849 |
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10.1007/s40242-013-3180-x doi (DE-627)SPR03290990X (SPR)s40242-013-3180-x-e DE-627 ger DE-627 rakwb eng Xiao, Yi verfasserin aut Conjugated polyelectrolyte-$ Ag^{+} $ fluorescent switch for biothiol sensing 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract A new “off-on” switch for sensitive and selective fluorescence detection of biothiols[glutathione(GSH), cysteine(Cys) and homocysteine(Hcy)] was developed based on an anionic conjugated polyelectrolyte(CPE), pyridyl-functionalized poly(phenylene ethynylene)(P1). The fluorescence of P1 can be significantly quenched by $ Ag^{+} $ due to complexation-mediated interpolymer aggregation. Furthermore, biothiols can efficiently recover the fluorescence intensity of P1 as a result of the stronger binding between thiol group and $ Ag^{+} $, which dissociates P1 from the P1/$ Ag^{+} $ complex and disrupts interpolymer aggregation. Under optimum conditions, a good linear relationship in a range of 100–4200 nmol/L is obtained for GSH with a detection limit of 80 nmol/L(S/N=3). As a result of specific interaction between the thiol group and $ Ag^{+} $, the proposed method shows a high selectivity for biothiols. In addition, the CPE-based fluorescence “off-on” switch has been used to quantitatively detect total biothiols in cell lysates. Fluorescent switch (dpeaa)DE-He213 Biothiol (dpeaa)DE-He213 Silver(I) (dpeaa)DE-He213 Conjugated polyelectrolyte (dpeaa)DE-He213 Li, Sha verfasserin aut Huang, Hong-mei verfasserin aut Zhang, Ye verfasserin aut Xue, Zun-zun verfasserin aut Tang, Xue-yan verfasserin aut He, Xiao-xiao verfasserin aut Wang, Ke-min verfasserin aut Enthalten in Chemical Research in Chinese Universities Jilin University and The Editorial Department of Chemical Research in Chinese Universities, 2012 29(2013), 5 vom: 06. Sept., Seite 845-849 (DE-627)SPR03290777X nnns volume:29 year:2013 number:5 day:06 month:09 pages:845-849 https://dx.doi.org/10.1007/s40242-013-3180-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 29 2013 5 06 09 845-849 |
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10.1007/s40242-013-3180-x doi (DE-627)SPR03290990X (SPR)s40242-013-3180-x-e DE-627 ger DE-627 rakwb eng Xiao, Yi verfasserin aut Conjugated polyelectrolyte-$ Ag^{+} $ fluorescent switch for biothiol sensing 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract A new “off-on” switch for sensitive and selective fluorescence detection of biothiols[glutathione(GSH), cysteine(Cys) and homocysteine(Hcy)] was developed based on an anionic conjugated polyelectrolyte(CPE), pyridyl-functionalized poly(phenylene ethynylene)(P1). The fluorescence of P1 can be significantly quenched by $ Ag^{+} $ due to complexation-mediated interpolymer aggregation. Furthermore, biothiols can efficiently recover the fluorescence intensity of P1 as a result of the stronger binding between thiol group and $ Ag^{+} $, which dissociates P1 from the P1/$ Ag^{+} $ complex and disrupts interpolymer aggregation. Under optimum conditions, a good linear relationship in a range of 100–4200 nmol/L is obtained for GSH with a detection limit of 80 nmol/L(S/N=3). As a result of specific interaction between the thiol group and $ Ag^{+} $, the proposed method shows a high selectivity for biothiols. In addition, the CPE-based fluorescence “off-on” switch has been used to quantitatively detect total biothiols in cell lysates. Fluorescent switch (dpeaa)DE-He213 Biothiol (dpeaa)DE-He213 Silver(I) (dpeaa)DE-He213 Conjugated polyelectrolyte (dpeaa)DE-He213 Li, Sha verfasserin aut Huang, Hong-mei verfasserin aut Zhang, Ye verfasserin aut Xue, Zun-zun verfasserin aut Tang, Xue-yan verfasserin aut He, Xiao-xiao verfasserin aut Wang, Ke-min verfasserin aut Enthalten in Chemical Research in Chinese Universities Jilin University and The Editorial Department of Chemical Research in Chinese Universities, 2012 29(2013), 5 vom: 06. Sept., Seite 845-849 (DE-627)SPR03290777X nnns volume:29 year:2013 number:5 day:06 month:09 pages:845-849 https://dx.doi.org/10.1007/s40242-013-3180-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 29 2013 5 06 09 845-849 |
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10.1007/s40242-013-3180-x doi (DE-627)SPR03290990X (SPR)s40242-013-3180-x-e DE-627 ger DE-627 rakwb eng Xiao, Yi verfasserin aut Conjugated polyelectrolyte-$ Ag^{+} $ fluorescent switch for biothiol sensing 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract A new “off-on” switch for sensitive and selective fluorescence detection of biothiols[glutathione(GSH), cysteine(Cys) and homocysteine(Hcy)] was developed based on an anionic conjugated polyelectrolyte(CPE), pyridyl-functionalized poly(phenylene ethynylene)(P1). The fluorescence of P1 can be significantly quenched by $ Ag^{+} $ due to complexation-mediated interpolymer aggregation. Furthermore, biothiols can efficiently recover the fluorescence intensity of P1 as a result of the stronger binding between thiol group and $ Ag^{+} $, which dissociates P1 from the P1/$ Ag^{+} $ complex and disrupts interpolymer aggregation. Under optimum conditions, a good linear relationship in a range of 100–4200 nmol/L is obtained for GSH with a detection limit of 80 nmol/L(S/N=3). As a result of specific interaction between the thiol group and $ Ag^{+} $, the proposed method shows a high selectivity for biothiols. In addition, the CPE-based fluorescence “off-on” switch has been used to quantitatively detect total biothiols in cell lysates. Fluorescent switch (dpeaa)DE-He213 Biothiol (dpeaa)DE-He213 Silver(I) (dpeaa)DE-He213 Conjugated polyelectrolyte (dpeaa)DE-He213 Li, Sha verfasserin aut Huang, Hong-mei verfasserin aut Zhang, Ye verfasserin aut Xue, Zun-zun verfasserin aut Tang, Xue-yan verfasserin aut He, Xiao-xiao verfasserin aut Wang, Ke-min verfasserin aut Enthalten in Chemical Research in Chinese Universities Jilin University and The Editorial Department of Chemical Research in Chinese Universities, 2012 29(2013), 5 vom: 06. Sept., Seite 845-849 (DE-627)SPR03290777X nnns volume:29 year:2013 number:5 day:06 month:09 pages:845-849 https://dx.doi.org/10.1007/s40242-013-3180-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 29 2013 5 06 09 845-849 |
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10.1007/s40242-013-3180-x doi (DE-627)SPR03290990X (SPR)s40242-013-3180-x-e DE-627 ger DE-627 rakwb eng Xiao, Yi verfasserin aut Conjugated polyelectrolyte-$ Ag^{+} $ fluorescent switch for biothiol sensing 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract A new “off-on” switch for sensitive and selective fluorescence detection of biothiols[glutathione(GSH), cysteine(Cys) and homocysteine(Hcy)] was developed based on an anionic conjugated polyelectrolyte(CPE), pyridyl-functionalized poly(phenylene ethynylene)(P1). The fluorescence of P1 can be significantly quenched by $ Ag^{+} $ due to complexation-mediated interpolymer aggregation. Furthermore, biothiols can efficiently recover the fluorescence intensity of P1 as a result of the stronger binding between thiol group and $ Ag^{+} $, which dissociates P1 from the P1/$ Ag^{+} $ complex and disrupts interpolymer aggregation. Under optimum conditions, a good linear relationship in a range of 100–4200 nmol/L is obtained for GSH with a detection limit of 80 nmol/L(S/N=3). As a result of specific interaction between the thiol group and $ Ag^{+} $, the proposed method shows a high selectivity for biothiols. In addition, the CPE-based fluorescence “off-on” switch has been used to quantitatively detect total biothiols in cell lysates. Fluorescent switch (dpeaa)DE-He213 Biothiol (dpeaa)DE-He213 Silver(I) (dpeaa)DE-He213 Conjugated polyelectrolyte (dpeaa)DE-He213 Li, Sha verfasserin aut Huang, Hong-mei verfasserin aut Zhang, Ye verfasserin aut Xue, Zun-zun verfasserin aut Tang, Xue-yan verfasserin aut He, Xiao-xiao verfasserin aut Wang, Ke-min verfasserin aut Enthalten in Chemical Research in Chinese Universities Jilin University and The Editorial Department of Chemical Research in Chinese Universities, 2012 29(2013), 5 vom: 06. Sept., Seite 845-849 (DE-627)SPR03290777X nnns volume:29 year:2013 number:5 day:06 month:09 pages:845-849 https://dx.doi.org/10.1007/s40242-013-3180-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 29 2013 5 06 09 845-849 |
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Xiao, Yi Li, Sha Huang, Hong-mei Zhang, Ye Xue, Zun-zun Tang, Xue-yan He, Xiao-xiao Wang, Ke-min |
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29 |
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Elektronische Aufsätze |
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Xiao, Yi |
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10.1007/s40242-013-3180-x |
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verfasserin |
| title_sort |
conjugated polyelectrolyte-$ ag^{+} $ fluorescent switch for biothiol sensing |
| title_auth |
Conjugated polyelectrolyte-$ Ag^{+} $ fluorescent switch for biothiol sensing |
| abstract |
Abstract A new “off-on” switch for sensitive and selective fluorescence detection of biothiols[glutathione(GSH), cysteine(Cys) and homocysteine(Hcy)] was developed based on an anionic conjugated polyelectrolyte(CPE), pyridyl-functionalized poly(phenylene ethynylene)(P1). The fluorescence of P1 can be significantly quenched by $ Ag^{+} $ due to complexation-mediated interpolymer aggregation. Furthermore, biothiols can efficiently recover the fluorescence intensity of P1 as a result of the stronger binding between thiol group and $ Ag^{+} $, which dissociates P1 from the P1/$ Ag^{+} $ complex and disrupts interpolymer aggregation. Under optimum conditions, a good linear relationship in a range of 100–4200 nmol/L is obtained for GSH with a detection limit of 80 nmol/L(S/N=3). As a result of specific interaction between the thiol group and $ Ag^{+} $, the proposed method shows a high selectivity for biothiols. In addition, the CPE-based fluorescence “off-on” switch has been used to quantitatively detect total biothiols in cell lysates. |
| abstractGer |
Abstract A new “off-on” switch for sensitive and selective fluorescence detection of biothiols[glutathione(GSH), cysteine(Cys) and homocysteine(Hcy)] was developed based on an anionic conjugated polyelectrolyte(CPE), pyridyl-functionalized poly(phenylene ethynylene)(P1). The fluorescence of P1 can be significantly quenched by $ Ag^{+} $ due to complexation-mediated interpolymer aggregation. Furthermore, biothiols can efficiently recover the fluorescence intensity of P1 as a result of the stronger binding between thiol group and $ Ag^{+} $, which dissociates P1 from the P1/$ Ag^{+} $ complex and disrupts interpolymer aggregation. Under optimum conditions, a good linear relationship in a range of 100–4200 nmol/L is obtained for GSH with a detection limit of 80 nmol/L(S/N=3). As a result of specific interaction between the thiol group and $ Ag^{+} $, the proposed method shows a high selectivity for biothiols. In addition, the CPE-based fluorescence “off-on” switch has been used to quantitatively detect total biothiols in cell lysates. |
| abstract_unstemmed |
Abstract A new “off-on” switch for sensitive and selective fluorescence detection of biothiols[glutathione(GSH), cysteine(Cys) and homocysteine(Hcy)] was developed based on an anionic conjugated polyelectrolyte(CPE), pyridyl-functionalized poly(phenylene ethynylene)(P1). The fluorescence of P1 can be significantly quenched by $ Ag^{+} $ due to complexation-mediated interpolymer aggregation. Furthermore, biothiols can efficiently recover the fluorescence intensity of P1 as a result of the stronger binding between thiol group and $ Ag^{+} $, which dissociates P1 from the P1/$ Ag^{+} $ complex and disrupts interpolymer aggregation. Under optimum conditions, a good linear relationship in a range of 100–4200 nmol/L is obtained for GSH with a detection limit of 80 nmol/L(S/N=3). As a result of specific interaction between the thiol group and $ Ag^{+} $, the proposed method shows a high selectivity for biothiols. In addition, the CPE-based fluorescence “off-on” switch has been used to quantitatively detect total biothiols in cell lysates. |
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GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA |
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5 |
| title_short |
Conjugated polyelectrolyte-$ Ag^{+} $ fluorescent switch for biothiol sensing |
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https://dx.doi.org/10.1007/s40242-013-3180-x |
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Li, Sha Huang, Hong-mei Zhang, Ye Xue, Zun-zun Tang, Xue-yan He, Xiao-xiao Wang, Ke-min |
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Li, Sha Huang, Hong-mei Zhang, Ye Xue, Zun-zun Tang, Xue-yan He, Xiao-xiao Wang, Ke-min |
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2024-07-03T15:24:39.502Z |
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