Losartan
Abstract ▴ Losartan binds selectively to the angiotensin II subtype 1 receptor, blocking the activity of angiotensin II. ▴ Losartan 50–100 mg/day was compared with atenolol 50–100 mg/ day in patients with essential hypertension and left ventricular hypertrophy (LVH) [n = 9193] in the randomized, dou...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Waugh, John [verfasserIn] Keating, Gillian M. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2003 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: American journal of cardiovascular drugs - Cham : Springer, 2001, 3(2003), 5 vom: Sept., Seite 371-377 |
|---|---|
| Übergeordnetes Werk: |
volume:3 ; year:2003 ; number:5 ; month:09 ; pages:371-377 |
| Links: |
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| DOI / URN: |
10.2165/00129784-200303050-00008 |
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| Katalog-ID: |
SPR032945450 |
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| 520 | |a Abstract ▴ Losartan binds selectively to the angiotensin II subtype 1 receptor, blocking the activity of angiotensin II. ▴ Losartan 50–100 mg/day was compared with atenolol 50–100 mg/ day in patients with essential hypertension and left ventricular hypertrophy (LVH) [n = 9193] in the randomized, double-blind Losartan Intervention For Endpoint reduction in hypertension (LIFE) study. Two substudies compared these drugs in patients with diabetes mellitus (n = 1195) or isolated systolic hypertension (ISH) [n = 1326]. ▴ The target BP (‘140/90mm Hg) was achieved in ≈45% of losartan and atenolol recipients in the LIFE study. Significant regression of LVH occurred with losartan versus atenolol in the LIFE study, as well as in the diabetes mellitus and ISH substudies. ▴ In the LIFE study, although BP reduction was similar for the two treatments, the risk of a cardiovascular event (the composite of cardiovascular death, stroke, and myocardial infarction; primary endpoint), stroke, or new-onset diabetes mellitus was significantly lower with losartan than with atenolol. ▴ Losartan was generally well tolerated in patients with hypertension and LVH in the LIFE study. Significantly fewer losartan than atenolol recipients discontinued treatment because of adverse events, drug-related adverse events, or serious, drug-related adverse events. | ||
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| 650 | 4 | |a Left Ventricular Hypertrophy |7 (dpeaa)DE-He213 | |
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| 650 | 4 | |a Adjusted Relative Risk |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Isolate Systolic Hypertension |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Keating, Gillian M. |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t American journal of cardiovascular drugs |d Cham : Springer, 2001 |g 3(2003), 5 vom: Sept., Seite 371-377 |w (DE-627)327643943 |w (DE-600)2043647-6 |x 1179-187X |7 nnns |
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| 952 | |d 3 |j 2003 |e 5 |c 09 |h 371-377 | ||
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2003 |
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2003 |
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10.2165/00129784-200303050-00008 doi (DE-627)SPR032945450 (SPR)00129784-200303050-00008-e DE-627 ger DE-627 rakwb eng 610 ASE Waugh, John verfasserin aut Losartan 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract ▴ Losartan binds selectively to the angiotensin II subtype 1 receptor, blocking the activity of angiotensin II. ▴ Losartan 50–100 mg/day was compared with atenolol 50–100 mg/ day in patients with essential hypertension and left ventricular hypertrophy (LVH) [n = 9193] in the randomized, double-blind Losartan Intervention For Endpoint reduction in hypertension (LIFE) study. Two substudies compared these drugs in patients with diabetes mellitus (n = 1195) or isolated systolic hypertension (ISH) [n = 1326]. ▴ The target BP (‘140/90mm Hg) was achieved in ≈45% of losartan and atenolol recipients in the LIFE study. Significant regression of LVH occurred with losartan versus atenolol in the LIFE study, as well as in the diabetes mellitus and ISH substudies. ▴ In the LIFE study, although BP reduction was similar for the two treatments, the risk of a cardiovascular event (the composite of cardiovascular death, stroke, and myocardial infarction; primary endpoint), stroke, or new-onset diabetes mellitus was significantly lower with losartan than with atenolol. ▴ Losartan was generally well tolerated in patients with hypertension and LVH in the LIFE study. Significantly fewer losartan than atenolol recipients discontinued treatment because of adverse events, drug-related adverse events, or serious, drug-related adverse events. Atenolol (dpeaa)DE-He213 Left Ventricular Hypertrophy (dpeaa)DE-He213 Losartan (dpeaa)DE-He213 Adjusted Relative Risk (dpeaa)DE-He213 Isolate Systolic Hypertension (dpeaa)DE-He213 Keating, Gillian M. verfasserin aut Enthalten in American journal of cardiovascular drugs Cham : Springer, 2001 3(2003), 5 vom: Sept., Seite 371-377 (DE-627)327643943 (DE-600)2043647-6 1179-187X nnns volume:3 year:2003 number:5 month:09 pages:371-377 https://dx.doi.org/10.2165/00129784-200303050-00008 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 3 2003 5 09 371-377 |
| spelling |
10.2165/00129784-200303050-00008 doi (DE-627)SPR032945450 (SPR)00129784-200303050-00008-e DE-627 ger DE-627 rakwb eng 610 ASE Waugh, John verfasserin aut Losartan 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract ▴ Losartan binds selectively to the angiotensin II subtype 1 receptor, blocking the activity of angiotensin II. ▴ Losartan 50–100 mg/day was compared with atenolol 50–100 mg/ day in patients with essential hypertension and left ventricular hypertrophy (LVH) [n = 9193] in the randomized, double-blind Losartan Intervention For Endpoint reduction in hypertension (LIFE) study. Two substudies compared these drugs in patients with diabetes mellitus (n = 1195) or isolated systolic hypertension (ISH) [n = 1326]. ▴ The target BP (‘140/90mm Hg) was achieved in ≈45% of losartan and atenolol recipients in the LIFE study. Significant regression of LVH occurred with losartan versus atenolol in the LIFE study, as well as in the diabetes mellitus and ISH substudies. ▴ In the LIFE study, although BP reduction was similar for the two treatments, the risk of a cardiovascular event (the composite of cardiovascular death, stroke, and myocardial infarction; primary endpoint), stroke, or new-onset diabetes mellitus was significantly lower with losartan than with atenolol. ▴ Losartan was generally well tolerated in patients with hypertension and LVH in the LIFE study. Significantly fewer losartan than atenolol recipients discontinued treatment because of adverse events, drug-related adverse events, or serious, drug-related adverse events. Atenolol (dpeaa)DE-He213 Left Ventricular Hypertrophy (dpeaa)DE-He213 Losartan (dpeaa)DE-He213 Adjusted Relative Risk (dpeaa)DE-He213 Isolate Systolic Hypertension (dpeaa)DE-He213 Keating, Gillian M. verfasserin aut Enthalten in American journal of cardiovascular drugs Cham : Springer, 2001 3(2003), 5 vom: Sept., Seite 371-377 (DE-627)327643943 (DE-600)2043647-6 1179-187X nnns volume:3 year:2003 number:5 month:09 pages:371-377 https://dx.doi.org/10.2165/00129784-200303050-00008 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 3 2003 5 09 371-377 |
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10.2165/00129784-200303050-00008 doi (DE-627)SPR032945450 (SPR)00129784-200303050-00008-e DE-627 ger DE-627 rakwb eng 610 ASE Waugh, John verfasserin aut Losartan 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract ▴ Losartan binds selectively to the angiotensin II subtype 1 receptor, blocking the activity of angiotensin II. ▴ Losartan 50–100 mg/day was compared with atenolol 50–100 mg/ day in patients with essential hypertension and left ventricular hypertrophy (LVH) [n = 9193] in the randomized, double-blind Losartan Intervention For Endpoint reduction in hypertension (LIFE) study. Two substudies compared these drugs in patients with diabetes mellitus (n = 1195) or isolated systolic hypertension (ISH) [n = 1326]. ▴ The target BP (‘140/90mm Hg) was achieved in ≈45% of losartan and atenolol recipients in the LIFE study. Significant regression of LVH occurred with losartan versus atenolol in the LIFE study, as well as in the diabetes mellitus and ISH substudies. ▴ In the LIFE study, although BP reduction was similar for the two treatments, the risk of a cardiovascular event (the composite of cardiovascular death, stroke, and myocardial infarction; primary endpoint), stroke, or new-onset diabetes mellitus was significantly lower with losartan than with atenolol. ▴ Losartan was generally well tolerated in patients with hypertension and LVH in the LIFE study. Significantly fewer losartan than atenolol recipients discontinued treatment because of adverse events, drug-related adverse events, or serious, drug-related adverse events. Atenolol (dpeaa)DE-He213 Left Ventricular Hypertrophy (dpeaa)DE-He213 Losartan (dpeaa)DE-He213 Adjusted Relative Risk (dpeaa)DE-He213 Isolate Systolic Hypertension (dpeaa)DE-He213 Keating, Gillian M. verfasserin aut Enthalten in American journal of cardiovascular drugs Cham : Springer, 2001 3(2003), 5 vom: Sept., Seite 371-377 (DE-627)327643943 (DE-600)2043647-6 1179-187X nnns volume:3 year:2003 number:5 month:09 pages:371-377 https://dx.doi.org/10.2165/00129784-200303050-00008 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 3 2003 5 09 371-377 |
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10.2165/00129784-200303050-00008 doi (DE-627)SPR032945450 (SPR)00129784-200303050-00008-e DE-627 ger DE-627 rakwb eng 610 ASE Waugh, John verfasserin aut Losartan 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract ▴ Losartan binds selectively to the angiotensin II subtype 1 receptor, blocking the activity of angiotensin II. ▴ Losartan 50–100 mg/day was compared with atenolol 50–100 mg/ day in patients with essential hypertension and left ventricular hypertrophy (LVH) [n = 9193] in the randomized, double-blind Losartan Intervention For Endpoint reduction in hypertension (LIFE) study. Two substudies compared these drugs in patients with diabetes mellitus (n = 1195) or isolated systolic hypertension (ISH) [n = 1326]. ▴ The target BP (‘140/90mm Hg) was achieved in ≈45% of losartan and atenolol recipients in the LIFE study. Significant regression of LVH occurred with losartan versus atenolol in the LIFE study, as well as in the diabetes mellitus and ISH substudies. ▴ In the LIFE study, although BP reduction was similar for the two treatments, the risk of a cardiovascular event (the composite of cardiovascular death, stroke, and myocardial infarction; primary endpoint), stroke, or new-onset diabetes mellitus was significantly lower with losartan than with atenolol. ▴ Losartan was generally well tolerated in patients with hypertension and LVH in the LIFE study. Significantly fewer losartan than atenolol recipients discontinued treatment because of adverse events, drug-related adverse events, or serious, drug-related adverse events. Atenolol (dpeaa)DE-He213 Left Ventricular Hypertrophy (dpeaa)DE-He213 Losartan (dpeaa)DE-He213 Adjusted Relative Risk (dpeaa)DE-He213 Isolate Systolic Hypertension (dpeaa)DE-He213 Keating, Gillian M. verfasserin aut Enthalten in American journal of cardiovascular drugs Cham : Springer, 2001 3(2003), 5 vom: Sept., Seite 371-377 (DE-627)327643943 (DE-600)2043647-6 1179-187X nnns volume:3 year:2003 number:5 month:09 pages:371-377 https://dx.doi.org/10.2165/00129784-200303050-00008 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 3 2003 5 09 371-377 |
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Enthalten in American journal of cardiovascular drugs 3(2003), 5 vom: Sept., Seite 371-377 volume:3 year:2003 number:5 month:09 pages:371-377 |
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Atenolol Left Ventricular Hypertrophy Losartan Adjusted Relative Risk Isolate Systolic Hypertension |
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Waugh, John @@aut@@ Keating, Gillian M. @@aut@@ |
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Waugh, John |
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Waugh, John ddc 610 misc Atenolol misc Left Ventricular Hypertrophy misc Losartan misc Adjusted Relative Risk misc Isolate Systolic Hypertension Losartan |
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610 ASE Losartan Atenolol (dpeaa)DE-He213 Left Ventricular Hypertrophy (dpeaa)DE-He213 Losartan (dpeaa)DE-He213 Adjusted Relative Risk (dpeaa)DE-He213 Isolate Systolic Hypertension (dpeaa)DE-He213 |
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ddc 610 misc Atenolol misc Left Ventricular Hypertrophy misc Losartan misc Adjusted Relative Risk misc Isolate Systolic Hypertension |
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| abstract |
Abstract ▴ Losartan binds selectively to the angiotensin II subtype 1 receptor, blocking the activity of angiotensin II. ▴ Losartan 50–100 mg/day was compared with atenolol 50–100 mg/ day in patients with essential hypertension and left ventricular hypertrophy (LVH) [n = 9193] in the randomized, double-blind Losartan Intervention For Endpoint reduction in hypertension (LIFE) study. Two substudies compared these drugs in patients with diabetes mellitus (n = 1195) or isolated systolic hypertension (ISH) [n = 1326]. ▴ The target BP (‘140/90mm Hg) was achieved in ≈45% of losartan and atenolol recipients in the LIFE study. Significant regression of LVH occurred with losartan versus atenolol in the LIFE study, as well as in the diabetes mellitus and ISH substudies. ▴ In the LIFE study, although BP reduction was similar for the two treatments, the risk of a cardiovascular event (the composite of cardiovascular death, stroke, and myocardial infarction; primary endpoint), stroke, or new-onset diabetes mellitus was significantly lower with losartan than with atenolol. ▴ Losartan was generally well tolerated in patients with hypertension and LVH in the LIFE study. Significantly fewer losartan than atenolol recipients discontinued treatment because of adverse events, drug-related adverse events, or serious, drug-related adverse events. |
| abstractGer |
Abstract ▴ Losartan binds selectively to the angiotensin II subtype 1 receptor, blocking the activity of angiotensin II. ▴ Losartan 50–100 mg/day was compared with atenolol 50–100 mg/ day in patients with essential hypertension and left ventricular hypertrophy (LVH) [n = 9193] in the randomized, double-blind Losartan Intervention For Endpoint reduction in hypertension (LIFE) study. Two substudies compared these drugs in patients with diabetes mellitus (n = 1195) or isolated systolic hypertension (ISH) [n = 1326]. ▴ The target BP (‘140/90mm Hg) was achieved in ≈45% of losartan and atenolol recipients in the LIFE study. Significant regression of LVH occurred with losartan versus atenolol in the LIFE study, as well as in the diabetes mellitus and ISH substudies. ▴ In the LIFE study, although BP reduction was similar for the two treatments, the risk of a cardiovascular event (the composite of cardiovascular death, stroke, and myocardial infarction; primary endpoint), stroke, or new-onset diabetes mellitus was significantly lower with losartan than with atenolol. ▴ Losartan was generally well tolerated in patients with hypertension and LVH in the LIFE study. Significantly fewer losartan than atenolol recipients discontinued treatment because of adverse events, drug-related adverse events, or serious, drug-related adverse events. |
| abstract_unstemmed |
Abstract ▴ Losartan binds selectively to the angiotensin II subtype 1 receptor, blocking the activity of angiotensin II. ▴ Losartan 50–100 mg/day was compared with atenolol 50–100 mg/ day in patients with essential hypertension and left ventricular hypertrophy (LVH) [n = 9193] in the randomized, double-blind Losartan Intervention For Endpoint reduction in hypertension (LIFE) study. Two substudies compared these drugs in patients with diabetes mellitus (n = 1195) or isolated systolic hypertension (ISH) [n = 1326]. ▴ The target BP (‘140/90mm Hg) was achieved in ≈45% of losartan and atenolol recipients in the LIFE study. Significant regression of LVH occurred with losartan versus atenolol in the LIFE study, as well as in the diabetes mellitus and ISH substudies. ▴ In the LIFE study, although BP reduction was similar for the two treatments, the risk of a cardiovascular event (the composite of cardiovascular death, stroke, and myocardial infarction; primary endpoint), stroke, or new-onset diabetes mellitus was significantly lower with losartan than with atenolol. ▴ Losartan was generally well tolerated in patients with hypertension and LVH in the LIFE study. Significantly fewer losartan than atenolol recipients discontinued treatment because of adverse events, drug-related adverse events, or serious, drug-related adverse events. |
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