Cetirizine, Oxatomide, Ketotifen and Placebo
Summary At 1-week intervals, 12 healthy volunteers received oral cetirizine 10mg, oxatomide 30mg, ketotifen 1mg or placebo under randomised double-blind crossover conditions. Wheal and flare were induced by skin prick tests using histamine 100 and 500 g/L before, and 4, 8 and 24 hours after, drug in...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Coulie, P. J. [verfasserIn] Ghys, L. [verfasserIn] Rihoux, J. -P. [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
1991 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Clinical drug investigation - Berlin [u.a.] : Springer, 1989, 3(1991), 5 vom: Okt., Seite 324-327 |
|---|---|
| Übergeordnetes Werk: |
volume:3 ; year:1991 ; number:5 ; month:10 ; pages:324-327 |
| Links: |
|---|
| DOI / URN: |
10.1007/BF03259746 |
|---|
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SPR032995725 |
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| 520 | |a Summary At 1-week intervals, 12 healthy volunteers received oral cetirizine 10mg, oxatomide 30mg, ketotifen 1mg or placebo under randomised double-blind crossover conditions. Wheal and flare were induced by skin prick tests using histamine 100 and 500 g/L before, and 4, 8 and 24 hours after, drug ingestion. At each session volunteers recorded levels of pruritus and sedation on two 10cm visual analogue scales. Cetirizine was significantly more potent than oxatomide (p = 0.0001), ketotifen (p = 0.0002) or placebo (p = 0.0001) in the inhibition of wheals, with similar results for flare (p = 0.0007, 0.0001 and 0.0002, respectively). Relief from pruritus was significantly better with cetirizine than with oxatomide (p = 0.003) or ketotifen (p = 0.002). Cetirizine was slightly better than placebo in relieving pruritus, but this was not statistically significant. Oxatomide and ketotifen were clearly more sedative than cetirizine (p = 0.05 and p = 0.0006, respectively), which was not significantly different from placebo. In conclusion, cetirizine appeared to be better in reducing histamine-induced wheal, flare and pruritus compared with ketotifen and oxatomide, and had less sedative effect. | ||
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10.1007/BF03259746 doi (DE-627)SPR032995725 (SPR)BF03259746-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Coulie, P. J. verfasserin aut Cetirizine, Oxatomide, Ketotifen and Placebo 1991 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary At 1-week intervals, 12 healthy volunteers received oral cetirizine 10mg, oxatomide 30mg, ketotifen 1mg or placebo under randomised double-blind crossover conditions. Wheal and flare were induced by skin prick tests using histamine 100 and 500 g/L before, and 4, 8 and 24 hours after, drug ingestion. At each session volunteers recorded levels of pruritus and sedation on two 10cm visual analogue scales. Cetirizine was significantly more potent than oxatomide (p = 0.0001), ketotifen (p = 0.0002) or placebo (p = 0.0001) in the inhibition of wheals, with similar results for flare (p = 0.0007, 0.0001 and 0.0002, respectively). Relief from pruritus was significantly better with cetirizine than with oxatomide (p = 0.003) or ketotifen (p = 0.002). Cetirizine was slightly better than placebo in relieving pruritus, but this was not statistically significant. Oxatomide and ketotifen were clearly more sedative than cetirizine (p = 0.05 and p = 0.0006, respectively), which was not significantly different from placebo. In conclusion, cetirizine appeared to be better in reducing histamine-induced wheal, flare and pruritus compared with ketotifen and oxatomide, and had less sedative effect. Histamine (dpeaa)DE-He213 Skin Prick Test (dpeaa)DE-He213 Terfenadine (dpeaa)DE-He213 Cetirizine (dpeaa)DE-He213 Loratadine (dpeaa)DE-He213 Ghys, L. verfasserin aut Rihoux, J. -P. verfasserin aut Enthalten in Clinical drug investigation Berlin [u.a.] : Springer, 1989 3(1991), 5 vom: Okt., Seite 324-327 (DE-627)327645083 (DE-600)2043793-6 1179-1918 nnns volume:3 year:1991 number:5 month:10 pages:324-327 https://dx.doi.org/10.1007/BF03259746 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_702 GBV_ILN_2190 44.40 ASE AR 3 1991 5 10 324-327 |
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10.1007/BF03259746 doi (DE-627)SPR032995725 (SPR)BF03259746-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Coulie, P. J. verfasserin aut Cetirizine, Oxatomide, Ketotifen and Placebo 1991 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary At 1-week intervals, 12 healthy volunteers received oral cetirizine 10mg, oxatomide 30mg, ketotifen 1mg or placebo under randomised double-blind crossover conditions. Wheal and flare were induced by skin prick tests using histamine 100 and 500 g/L before, and 4, 8 and 24 hours after, drug ingestion. At each session volunteers recorded levels of pruritus and sedation on two 10cm visual analogue scales. Cetirizine was significantly more potent than oxatomide (p = 0.0001), ketotifen (p = 0.0002) or placebo (p = 0.0001) in the inhibition of wheals, with similar results for flare (p = 0.0007, 0.0001 and 0.0002, respectively). Relief from pruritus was significantly better with cetirizine than with oxatomide (p = 0.003) or ketotifen (p = 0.002). Cetirizine was slightly better than placebo in relieving pruritus, but this was not statistically significant. Oxatomide and ketotifen were clearly more sedative than cetirizine (p = 0.05 and p = 0.0006, respectively), which was not significantly different from placebo. In conclusion, cetirizine appeared to be better in reducing histamine-induced wheal, flare and pruritus compared with ketotifen and oxatomide, and had less sedative effect. Histamine (dpeaa)DE-He213 Skin Prick Test (dpeaa)DE-He213 Terfenadine (dpeaa)DE-He213 Cetirizine (dpeaa)DE-He213 Loratadine (dpeaa)DE-He213 Ghys, L. verfasserin aut Rihoux, J. -P. verfasserin aut Enthalten in Clinical drug investigation Berlin [u.a.] : Springer, 1989 3(1991), 5 vom: Okt., Seite 324-327 (DE-627)327645083 (DE-600)2043793-6 1179-1918 nnns volume:3 year:1991 number:5 month:10 pages:324-327 https://dx.doi.org/10.1007/BF03259746 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_702 GBV_ILN_2190 44.40 ASE AR 3 1991 5 10 324-327 |
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10.1007/BF03259746 doi (DE-627)SPR032995725 (SPR)BF03259746-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Coulie, P. J. verfasserin aut Cetirizine, Oxatomide, Ketotifen and Placebo 1991 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary At 1-week intervals, 12 healthy volunteers received oral cetirizine 10mg, oxatomide 30mg, ketotifen 1mg or placebo under randomised double-blind crossover conditions. Wheal and flare were induced by skin prick tests using histamine 100 and 500 g/L before, and 4, 8 and 24 hours after, drug ingestion. At each session volunteers recorded levels of pruritus and sedation on two 10cm visual analogue scales. Cetirizine was significantly more potent than oxatomide (p = 0.0001), ketotifen (p = 0.0002) or placebo (p = 0.0001) in the inhibition of wheals, with similar results for flare (p = 0.0007, 0.0001 and 0.0002, respectively). Relief from pruritus was significantly better with cetirizine than with oxatomide (p = 0.003) or ketotifen (p = 0.002). Cetirizine was slightly better than placebo in relieving pruritus, but this was not statistically significant. Oxatomide and ketotifen were clearly more sedative than cetirizine (p = 0.05 and p = 0.0006, respectively), which was not significantly different from placebo. In conclusion, cetirizine appeared to be better in reducing histamine-induced wheal, flare and pruritus compared with ketotifen and oxatomide, and had less sedative effect. Histamine (dpeaa)DE-He213 Skin Prick Test (dpeaa)DE-He213 Terfenadine (dpeaa)DE-He213 Cetirizine (dpeaa)DE-He213 Loratadine (dpeaa)DE-He213 Ghys, L. verfasserin aut Rihoux, J. -P. verfasserin aut Enthalten in Clinical drug investigation Berlin [u.a.] : Springer, 1989 3(1991), 5 vom: Okt., Seite 324-327 (DE-627)327645083 (DE-600)2043793-6 1179-1918 nnns volume:3 year:1991 number:5 month:10 pages:324-327 https://dx.doi.org/10.1007/BF03259746 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_702 GBV_ILN_2190 44.40 ASE AR 3 1991 5 10 324-327 |
| allfieldsGer |
10.1007/BF03259746 doi (DE-627)SPR032995725 (SPR)BF03259746-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Coulie, P. J. verfasserin aut Cetirizine, Oxatomide, Ketotifen and Placebo 1991 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary At 1-week intervals, 12 healthy volunteers received oral cetirizine 10mg, oxatomide 30mg, ketotifen 1mg or placebo under randomised double-blind crossover conditions. Wheal and flare were induced by skin prick tests using histamine 100 and 500 g/L before, and 4, 8 and 24 hours after, drug ingestion. At each session volunteers recorded levels of pruritus and sedation on two 10cm visual analogue scales. Cetirizine was significantly more potent than oxatomide (p = 0.0001), ketotifen (p = 0.0002) or placebo (p = 0.0001) in the inhibition of wheals, with similar results for flare (p = 0.0007, 0.0001 and 0.0002, respectively). Relief from pruritus was significantly better with cetirizine than with oxatomide (p = 0.003) or ketotifen (p = 0.002). Cetirizine was slightly better than placebo in relieving pruritus, but this was not statistically significant. Oxatomide and ketotifen were clearly more sedative than cetirizine (p = 0.05 and p = 0.0006, respectively), which was not significantly different from placebo. In conclusion, cetirizine appeared to be better in reducing histamine-induced wheal, flare and pruritus compared with ketotifen and oxatomide, and had less sedative effect. Histamine (dpeaa)DE-He213 Skin Prick Test (dpeaa)DE-He213 Terfenadine (dpeaa)DE-He213 Cetirizine (dpeaa)DE-He213 Loratadine (dpeaa)DE-He213 Ghys, L. verfasserin aut Rihoux, J. -P. verfasserin aut Enthalten in Clinical drug investigation Berlin [u.a.] : Springer, 1989 3(1991), 5 vom: Okt., Seite 324-327 (DE-627)327645083 (DE-600)2043793-6 1179-1918 nnns volume:3 year:1991 number:5 month:10 pages:324-327 https://dx.doi.org/10.1007/BF03259746 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_702 GBV_ILN_2190 44.40 ASE AR 3 1991 5 10 324-327 |
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10.1007/BF03259746 doi (DE-627)SPR032995725 (SPR)BF03259746-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Coulie, P. J. verfasserin aut Cetirizine, Oxatomide, Ketotifen and Placebo 1991 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary At 1-week intervals, 12 healthy volunteers received oral cetirizine 10mg, oxatomide 30mg, ketotifen 1mg or placebo under randomised double-blind crossover conditions. Wheal and flare were induced by skin prick tests using histamine 100 and 500 g/L before, and 4, 8 and 24 hours after, drug ingestion. At each session volunteers recorded levels of pruritus and sedation on two 10cm visual analogue scales. Cetirizine was significantly more potent than oxatomide (p = 0.0001), ketotifen (p = 0.0002) or placebo (p = 0.0001) in the inhibition of wheals, with similar results for flare (p = 0.0007, 0.0001 and 0.0002, respectively). Relief from pruritus was significantly better with cetirizine than with oxatomide (p = 0.003) or ketotifen (p = 0.002). Cetirizine was slightly better than placebo in relieving pruritus, but this was not statistically significant. Oxatomide and ketotifen were clearly more sedative than cetirizine (p = 0.05 and p = 0.0006, respectively), which was not significantly different from placebo. In conclusion, cetirizine appeared to be better in reducing histamine-induced wheal, flare and pruritus compared with ketotifen and oxatomide, and had less sedative effect. Histamine (dpeaa)DE-He213 Skin Prick Test (dpeaa)DE-He213 Terfenadine (dpeaa)DE-He213 Cetirizine (dpeaa)DE-He213 Loratadine (dpeaa)DE-He213 Ghys, L. verfasserin aut Rihoux, J. -P. verfasserin aut Enthalten in Clinical drug investigation Berlin [u.a.] : Springer, 1989 3(1991), 5 vom: Okt., Seite 324-327 (DE-627)327645083 (DE-600)2043793-6 1179-1918 nnns volume:3 year:1991 number:5 month:10 pages:324-327 https://dx.doi.org/10.1007/BF03259746 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_702 GBV_ILN_2190 44.40 ASE AR 3 1991 5 10 324-327 |
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Coulie, P. J. |
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Clinical drug investigation |
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Cetirizine, Oxatomide, Ketotifen and Placebo |
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Cetirizine, Oxatomide, Ketotifen and Placebo |
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Coulie, P. J. |
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Clinical drug investigation |
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1991 |
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Coulie, P. J. Ghys, L. Rihoux, J. -P. |
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Coulie, P. J. |
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10.1007/BF03259746 |
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610 |
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cetirizine, oxatomide, ketotifen and placebo |
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Cetirizine, Oxatomide, Ketotifen and Placebo |
| abstract |
Summary At 1-week intervals, 12 healthy volunteers received oral cetirizine 10mg, oxatomide 30mg, ketotifen 1mg or placebo under randomised double-blind crossover conditions. Wheal and flare were induced by skin prick tests using histamine 100 and 500 g/L before, and 4, 8 and 24 hours after, drug ingestion. At each session volunteers recorded levels of pruritus and sedation on two 10cm visual analogue scales. Cetirizine was significantly more potent than oxatomide (p = 0.0001), ketotifen (p = 0.0002) or placebo (p = 0.0001) in the inhibition of wheals, with similar results for flare (p = 0.0007, 0.0001 and 0.0002, respectively). Relief from pruritus was significantly better with cetirizine than with oxatomide (p = 0.003) or ketotifen (p = 0.002). Cetirizine was slightly better than placebo in relieving pruritus, but this was not statistically significant. Oxatomide and ketotifen were clearly more sedative than cetirizine (p = 0.05 and p = 0.0006, respectively), which was not significantly different from placebo. In conclusion, cetirizine appeared to be better in reducing histamine-induced wheal, flare and pruritus compared with ketotifen and oxatomide, and had less sedative effect. |
| abstractGer |
Summary At 1-week intervals, 12 healthy volunteers received oral cetirizine 10mg, oxatomide 30mg, ketotifen 1mg or placebo under randomised double-blind crossover conditions. Wheal and flare were induced by skin prick tests using histamine 100 and 500 g/L before, and 4, 8 and 24 hours after, drug ingestion. At each session volunteers recorded levels of pruritus and sedation on two 10cm visual analogue scales. Cetirizine was significantly more potent than oxatomide (p = 0.0001), ketotifen (p = 0.0002) or placebo (p = 0.0001) in the inhibition of wheals, with similar results for flare (p = 0.0007, 0.0001 and 0.0002, respectively). Relief from pruritus was significantly better with cetirizine than with oxatomide (p = 0.003) or ketotifen (p = 0.002). Cetirizine was slightly better than placebo in relieving pruritus, but this was not statistically significant. Oxatomide and ketotifen were clearly more sedative than cetirizine (p = 0.05 and p = 0.0006, respectively), which was not significantly different from placebo. In conclusion, cetirizine appeared to be better in reducing histamine-induced wheal, flare and pruritus compared with ketotifen and oxatomide, and had less sedative effect. |
| abstract_unstemmed |
Summary At 1-week intervals, 12 healthy volunteers received oral cetirizine 10mg, oxatomide 30mg, ketotifen 1mg or placebo under randomised double-blind crossover conditions. Wheal and flare were induced by skin prick tests using histamine 100 and 500 g/L before, and 4, 8 and 24 hours after, drug ingestion. At each session volunteers recorded levels of pruritus and sedation on two 10cm visual analogue scales. Cetirizine was significantly more potent than oxatomide (p = 0.0001), ketotifen (p = 0.0002) or placebo (p = 0.0001) in the inhibition of wheals, with similar results for flare (p = 0.0007, 0.0001 and 0.0002, respectively). Relief from pruritus was significantly better with cetirizine than with oxatomide (p = 0.003) or ketotifen (p = 0.002). Cetirizine was slightly better than placebo in relieving pruritus, but this was not statistically significant. Oxatomide and ketotifen were clearly more sedative than cetirizine (p = 0.05 and p = 0.0006, respectively), which was not significantly different from placebo. In conclusion, cetirizine appeared to be better in reducing histamine-induced wheal, flare and pruritus compared with ketotifen and oxatomide, and had less sedative effect. |
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Cetirizine, Oxatomide, Ketotifen and Placebo |
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