Anti-Ischaemic Efficacy of Amlodipine vs Nifedipine in the Treatment of Patients with Stable Exertional Angina
Summary The anti-ischaemic effects of amlodipine were compared with those of sustained release nifedipine in 53 patients with exertional angina. After a 1-week drug washout phase, patients were randomised to receive amlodipine (5mg once daily) or sustained release nifedipine (20mg twice daily). Afte...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Pandolfo, Luciano [verfasserIn] Pajes, Giuseppe [verfasserIn] Zardi, Domenico [verfasserIn] Giorgi, Gabriele [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1997 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Clinical drug investigation - Berlin [u.a.] : Springer, 1989, 13(1997), Suppl 1 vom: Juni, Seite 113-118 |
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| Übergeordnetes Werk: |
volume:13 ; year:1997 ; number:Suppl 1 ; month:06 ; pages:113-118 |
| Links: |
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| DOI / URN: |
10.2165/00044011-199700131-00020 |
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| Katalog-ID: |
SPR033003971 |
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| 100 | 1 | |a Pandolfo, Luciano |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Anti-Ischaemic Efficacy of Amlodipine vs Nifedipine in the Treatment of Patients with Stable Exertional Angina |
| 264 | 1 | |c 1997 | |
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| 520 | |a Summary The anti-ischaemic effects of amlodipine were compared with those of sustained release nifedipine in 53 patients with exertional angina. After a 1-week drug washout phase, patients were randomised to receive amlodipine (5mg once daily) or sustained release nifedipine (20mg twice daily). After 2 weeks of treatment, initial doses were doubled if there was inadequate control of symptoms in the absence of adverse events. Compared with nifedipine, amlodipine was associated with greater reductions in the frequency of angina and nitrate use and a lower incidence of adverse effects (ankle oedema, palpitations). In dynamic stress tests, amlodipine recipients showed a greater increase (over baseline) in the rate-pressure product (systolic blood pressure × heart rate) at ischaemic threshold than those treated with nifedipine, thus suggesting a superior improvement in exercise tolerance. In conclusion, amlodipine shows superior antianginal efficacy to nifedipine with a lower incidence of adverse effects. | ||
| 650 | 4 | |a Nifedipine |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Amlodipine |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Drug Invest |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Amlodipine Group |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Exertional Angina |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Pajes, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Zardi, Domenico |e verfasserin |4 aut | |
| 700 | 1 | |a Giorgi, Gabriele |e verfasserin |4 aut | |
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10.2165/00044011-199700131-00020 doi (DE-627)SPR033003971 (SPR)00044011-199700131-00020-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Pandolfo, Luciano verfasserin aut Anti-Ischaemic Efficacy of Amlodipine vs Nifedipine in the Treatment of Patients with Stable Exertional Angina 1997 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary The anti-ischaemic effects of amlodipine were compared with those of sustained release nifedipine in 53 patients with exertional angina. After a 1-week drug washout phase, patients were randomised to receive amlodipine (5mg once daily) or sustained release nifedipine (20mg twice daily). After 2 weeks of treatment, initial doses were doubled if there was inadequate control of symptoms in the absence of adverse events. Compared with nifedipine, amlodipine was associated with greater reductions in the frequency of angina and nitrate use and a lower incidence of adverse effects (ankle oedema, palpitations). In dynamic stress tests, amlodipine recipients showed a greater increase (over baseline) in the rate-pressure product (systolic blood pressure × heart rate) at ischaemic threshold than those treated with nifedipine, thus suggesting a superior improvement in exercise tolerance. In conclusion, amlodipine shows superior antianginal efficacy to nifedipine with a lower incidence of adverse effects. Nifedipine (dpeaa)DE-He213 Amlodipine (dpeaa)DE-He213 Drug Invest (dpeaa)DE-He213 Amlodipine Group (dpeaa)DE-He213 Exertional Angina (dpeaa)DE-He213 Pajes, Giuseppe verfasserin aut Zardi, Domenico verfasserin aut Giorgi, Gabriele verfasserin aut Enthalten in Clinical drug investigation Berlin [u.a.] : Springer, 1989 13(1997), Suppl 1 vom: Juni, Seite 113-118 (DE-627)327645083 (DE-600)2043793-6 1179-1918 nnns volume:13 year:1997 number:Suppl 1 month:06 pages:113-118 https://dx.doi.org/10.2165/00044011-199700131-00020 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 13 1997 Suppl 1 06 113-118 |
| spelling |
10.2165/00044011-199700131-00020 doi (DE-627)SPR033003971 (SPR)00044011-199700131-00020-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Pandolfo, Luciano verfasserin aut Anti-Ischaemic Efficacy of Amlodipine vs Nifedipine in the Treatment of Patients with Stable Exertional Angina 1997 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary The anti-ischaemic effects of amlodipine were compared with those of sustained release nifedipine in 53 patients with exertional angina. After a 1-week drug washout phase, patients were randomised to receive amlodipine (5mg once daily) or sustained release nifedipine (20mg twice daily). After 2 weeks of treatment, initial doses were doubled if there was inadequate control of symptoms in the absence of adverse events. Compared with nifedipine, amlodipine was associated with greater reductions in the frequency of angina and nitrate use and a lower incidence of adverse effects (ankle oedema, palpitations). In dynamic stress tests, amlodipine recipients showed a greater increase (over baseline) in the rate-pressure product (systolic blood pressure × heart rate) at ischaemic threshold than those treated with nifedipine, thus suggesting a superior improvement in exercise tolerance. In conclusion, amlodipine shows superior antianginal efficacy to nifedipine with a lower incidence of adverse effects. Nifedipine (dpeaa)DE-He213 Amlodipine (dpeaa)DE-He213 Drug Invest (dpeaa)DE-He213 Amlodipine Group (dpeaa)DE-He213 Exertional Angina (dpeaa)DE-He213 Pajes, Giuseppe verfasserin aut Zardi, Domenico verfasserin aut Giorgi, Gabriele verfasserin aut Enthalten in Clinical drug investigation Berlin [u.a.] : Springer, 1989 13(1997), Suppl 1 vom: Juni, Seite 113-118 (DE-627)327645083 (DE-600)2043793-6 1179-1918 nnns volume:13 year:1997 number:Suppl 1 month:06 pages:113-118 https://dx.doi.org/10.2165/00044011-199700131-00020 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 13 1997 Suppl 1 06 113-118 |
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10.2165/00044011-199700131-00020 doi (DE-627)SPR033003971 (SPR)00044011-199700131-00020-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Pandolfo, Luciano verfasserin aut Anti-Ischaemic Efficacy of Amlodipine vs Nifedipine in the Treatment of Patients with Stable Exertional Angina 1997 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary The anti-ischaemic effects of amlodipine were compared with those of sustained release nifedipine in 53 patients with exertional angina. After a 1-week drug washout phase, patients were randomised to receive amlodipine (5mg once daily) or sustained release nifedipine (20mg twice daily). After 2 weeks of treatment, initial doses were doubled if there was inadequate control of symptoms in the absence of adverse events. Compared with nifedipine, amlodipine was associated with greater reductions in the frequency of angina and nitrate use and a lower incidence of adverse effects (ankle oedema, palpitations). In dynamic stress tests, amlodipine recipients showed a greater increase (over baseline) in the rate-pressure product (systolic blood pressure × heart rate) at ischaemic threshold than those treated with nifedipine, thus suggesting a superior improvement in exercise tolerance. In conclusion, amlodipine shows superior antianginal efficacy to nifedipine with a lower incidence of adverse effects. Nifedipine (dpeaa)DE-He213 Amlodipine (dpeaa)DE-He213 Drug Invest (dpeaa)DE-He213 Amlodipine Group (dpeaa)DE-He213 Exertional Angina (dpeaa)DE-He213 Pajes, Giuseppe verfasserin aut Zardi, Domenico verfasserin aut Giorgi, Gabriele verfasserin aut Enthalten in Clinical drug investigation Berlin [u.a.] : Springer, 1989 13(1997), Suppl 1 vom: Juni, Seite 113-118 (DE-627)327645083 (DE-600)2043793-6 1179-1918 nnns volume:13 year:1997 number:Suppl 1 month:06 pages:113-118 https://dx.doi.org/10.2165/00044011-199700131-00020 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 13 1997 Suppl 1 06 113-118 |
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10.2165/00044011-199700131-00020 doi (DE-627)SPR033003971 (SPR)00044011-199700131-00020-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Pandolfo, Luciano verfasserin aut Anti-Ischaemic Efficacy of Amlodipine vs Nifedipine in the Treatment of Patients with Stable Exertional Angina 1997 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary The anti-ischaemic effects of amlodipine were compared with those of sustained release nifedipine in 53 patients with exertional angina. After a 1-week drug washout phase, patients were randomised to receive amlodipine (5mg once daily) or sustained release nifedipine (20mg twice daily). After 2 weeks of treatment, initial doses were doubled if there was inadequate control of symptoms in the absence of adverse events. Compared with nifedipine, amlodipine was associated with greater reductions in the frequency of angina and nitrate use and a lower incidence of adverse effects (ankle oedema, palpitations). In dynamic stress tests, amlodipine recipients showed a greater increase (over baseline) in the rate-pressure product (systolic blood pressure × heart rate) at ischaemic threshold than those treated with nifedipine, thus suggesting a superior improvement in exercise tolerance. In conclusion, amlodipine shows superior antianginal efficacy to nifedipine with a lower incidence of adverse effects. Nifedipine (dpeaa)DE-He213 Amlodipine (dpeaa)DE-He213 Drug Invest (dpeaa)DE-He213 Amlodipine Group (dpeaa)DE-He213 Exertional Angina (dpeaa)DE-He213 Pajes, Giuseppe verfasserin aut Zardi, Domenico verfasserin aut Giorgi, Gabriele verfasserin aut Enthalten in Clinical drug investigation Berlin [u.a.] : Springer, 1989 13(1997), Suppl 1 vom: Juni, Seite 113-118 (DE-627)327645083 (DE-600)2043793-6 1179-1918 nnns volume:13 year:1997 number:Suppl 1 month:06 pages:113-118 https://dx.doi.org/10.2165/00044011-199700131-00020 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 13 1997 Suppl 1 06 113-118 |
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10.2165/00044011-199700131-00020 doi (DE-627)SPR033003971 (SPR)00044011-199700131-00020-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Pandolfo, Luciano verfasserin aut Anti-Ischaemic Efficacy of Amlodipine vs Nifedipine in the Treatment of Patients with Stable Exertional Angina 1997 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary The anti-ischaemic effects of amlodipine were compared with those of sustained release nifedipine in 53 patients with exertional angina. After a 1-week drug washout phase, patients were randomised to receive amlodipine (5mg once daily) or sustained release nifedipine (20mg twice daily). After 2 weeks of treatment, initial doses were doubled if there was inadequate control of symptoms in the absence of adverse events. Compared with nifedipine, amlodipine was associated with greater reductions in the frequency of angina and nitrate use and a lower incidence of adverse effects (ankle oedema, palpitations). In dynamic stress tests, amlodipine recipients showed a greater increase (over baseline) in the rate-pressure product (systolic blood pressure × heart rate) at ischaemic threshold than those treated with nifedipine, thus suggesting a superior improvement in exercise tolerance. In conclusion, amlodipine shows superior antianginal efficacy to nifedipine with a lower incidence of adverse effects. Nifedipine (dpeaa)DE-He213 Amlodipine (dpeaa)DE-He213 Drug Invest (dpeaa)DE-He213 Amlodipine Group (dpeaa)DE-He213 Exertional Angina (dpeaa)DE-He213 Pajes, Giuseppe verfasserin aut Zardi, Domenico verfasserin aut Giorgi, Gabriele verfasserin aut Enthalten in Clinical drug investigation Berlin [u.a.] : Springer, 1989 13(1997), Suppl 1 vom: Juni, Seite 113-118 (DE-627)327645083 (DE-600)2043793-6 1179-1918 nnns volume:13 year:1997 number:Suppl 1 month:06 pages:113-118 https://dx.doi.org/10.2165/00044011-199700131-00020 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 13 1997 Suppl 1 06 113-118 |
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English |
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Enthalten in Clinical drug investigation 13(1997), Suppl 1 vom: Juni, Seite 113-118 volume:13 year:1997 number:Suppl 1 month:06 pages:113-118 |
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Enthalten in Clinical drug investigation 13(1997), Suppl 1 vom: Juni, Seite 113-118 volume:13 year:1997 number:Suppl 1 month:06 pages:113-118 |
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Nifedipine Amlodipine Drug Invest Amlodipine Group Exertional Angina |
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Clinical drug investigation |
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Pandolfo, Luciano @@aut@@ Pajes, Giuseppe @@aut@@ Zardi, Domenico @@aut@@ Giorgi, Gabriele @@aut@@ |
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1997-06-01T00:00:00Z |
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327645083 |
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Pandolfo, Luciano |
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Pandolfo, Luciano ddc 610 bkl 44.40 misc Nifedipine misc Amlodipine misc Drug Invest misc Amlodipine Group misc Exertional Angina Anti-Ischaemic Efficacy of Amlodipine vs Nifedipine in the Treatment of Patients with Stable Exertional Angina |
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610 ASE 44.40 bkl Anti-Ischaemic Efficacy of Amlodipine vs Nifedipine in the Treatment of Patients with Stable Exertional Angina Nifedipine (dpeaa)DE-He213 Amlodipine (dpeaa)DE-He213 Drug Invest (dpeaa)DE-He213 Amlodipine Group (dpeaa)DE-He213 Exertional Angina (dpeaa)DE-He213 |
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Anti-Ischaemic Efficacy of Amlodipine vs Nifedipine in the Treatment of Patients with Stable Exertional Angina |
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Anti-Ischaemic Efficacy of Amlodipine vs Nifedipine in the Treatment of Patients with Stable Exertional Angina |
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anti-ischaemic efficacy of amlodipine vs nifedipine in the treatment of patients with stable exertional angina |
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Anti-Ischaemic Efficacy of Amlodipine vs Nifedipine in the Treatment of Patients with Stable Exertional Angina |
| abstract |
Summary The anti-ischaemic effects of amlodipine were compared with those of sustained release nifedipine in 53 patients with exertional angina. After a 1-week drug washout phase, patients were randomised to receive amlodipine (5mg once daily) or sustained release nifedipine (20mg twice daily). After 2 weeks of treatment, initial doses were doubled if there was inadequate control of symptoms in the absence of adverse events. Compared with nifedipine, amlodipine was associated with greater reductions in the frequency of angina and nitrate use and a lower incidence of adverse effects (ankle oedema, palpitations). In dynamic stress tests, amlodipine recipients showed a greater increase (over baseline) in the rate-pressure product (systolic blood pressure × heart rate) at ischaemic threshold than those treated with nifedipine, thus suggesting a superior improvement in exercise tolerance. In conclusion, amlodipine shows superior antianginal efficacy to nifedipine with a lower incidence of adverse effects. |
| abstractGer |
Summary The anti-ischaemic effects of amlodipine were compared with those of sustained release nifedipine in 53 patients with exertional angina. After a 1-week drug washout phase, patients were randomised to receive amlodipine (5mg once daily) or sustained release nifedipine (20mg twice daily). After 2 weeks of treatment, initial doses were doubled if there was inadequate control of symptoms in the absence of adverse events. Compared with nifedipine, amlodipine was associated with greater reductions in the frequency of angina and nitrate use and a lower incidence of adverse effects (ankle oedema, palpitations). In dynamic stress tests, amlodipine recipients showed a greater increase (over baseline) in the rate-pressure product (systolic blood pressure × heart rate) at ischaemic threshold than those treated with nifedipine, thus suggesting a superior improvement in exercise tolerance. In conclusion, amlodipine shows superior antianginal efficacy to nifedipine with a lower incidence of adverse effects. |
| abstract_unstemmed |
Summary The anti-ischaemic effects of amlodipine were compared with those of sustained release nifedipine in 53 patients with exertional angina. After a 1-week drug washout phase, patients were randomised to receive amlodipine (5mg once daily) or sustained release nifedipine (20mg twice daily). After 2 weeks of treatment, initial doses were doubled if there was inadequate control of symptoms in the absence of adverse events. Compared with nifedipine, amlodipine was associated with greater reductions in the frequency of angina and nitrate use and a lower incidence of adverse effects (ankle oedema, palpitations). In dynamic stress tests, amlodipine recipients showed a greater increase (over baseline) in the rate-pressure product (systolic blood pressure × heart rate) at ischaemic threshold than those treated with nifedipine, thus suggesting a superior improvement in exercise tolerance. In conclusion, amlodipine shows superior antianginal efficacy to nifedipine with a lower incidence of adverse effects. |
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Suppl 1 |
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Anti-Ischaemic Efficacy of Amlodipine vs Nifedipine in the Treatment of Patients with Stable Exertional Angina |
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https://dx.doi.org/10.2165/00044011-199700131-00020 |
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Pajes, Giuseppe Zardi, Domenico Giorgi, Gabriele |
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10.2165/00044011-199700131-00020 |
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2024-07-03T15:58:59.335Z |
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code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">13</subfield><subfield code="j">1997</subfield><subfield code="e">Suppl 1</subfield><subfield code="c">06</subfield><subfield code="h">113-118</subfield></datafield></record></collection>
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| score |
7.398429 |