Efficacy and Tolerability of Valsartan Compared with Lisinopril in Patients with Hypertension and Renal Insufficiency
Summary This study compared the efficacy and tolerability of valsartan with an angiotensin converting enzyme inhibitor, lisinopril, in hypertensive patients with renal insufficiency. A total of 188 male and female outpatients with stable renal insufficiency [creatinine clearance ($ CL_{CR} $) 20 to...
Ausführliche Beschreibung
Autor*in: |
Perico, Norberto [verfasserIn] Spormann, D. [verfasserIn] Peruzzi, E. [verfasserIn] Bodin, F. [verfasserIn] Sioufi, Antoine [verfasserIn] Bertocchi, F. [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
1997 |
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Schlagwörter: |
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Übergeordnetes Werk: |
Enthalten in: Clinical drug investigation - Berlin [u.a.] : Springer, 1989, 14(1997), 4 vom: Okt., Seite 252-259 |
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Übergeordnetes Werk: |
volume:14 ; year:1997 ; number:4 ; month:10 ; pages:252-259 |
Links: |
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DOI / URN: |
10.2165/00044011-199714040-00002 |
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Katalog-ID: |
SPR033004447 |
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100 | 1 | |a Perico, Norberto |e verfasserin |4 aut | |
245 | 1 | 0 | |a Efficacy and Tolerability of Valsartan Compared with Lisinopril in Patients with Hypertension and Renal Insufficiency |
264 | 1 | |c 1997 | |
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520 | |a Summary This study compared the efficacy and tolerability of valsartan with an angiotensin converting enzyme inhibitor, lisinopril, in hypertensive patients with renal insufficiency. A total of 188 male and female outpatients with stable renal insufficiency [creatinine clearance ($ CL_{CR} $) 20 to 70 ml/min/1.$ 73m^{2} $] were randomised in a 1:1 ratio to receive valsartan or lisinopril in this single-centre, double-blind 13-week trial. Patients were stratified prior to randomisation according to $ CL_{CR} $ — stratum 1: $ CL_{CR} $ 20 to 30 ml/min/1.$ 73m^{2} $; stratum 2: $ CL_{CR} $ 31 to 70 ml/min/1.$ 73m^{2} $. Stratum 1 patients received once-daily valsartan 40mg or lisinopril 2.5mg for 1 week, increasing to 80mg or 5mg, respectively, for 12 weeks. Stratum 2 patients received once-daily valsartan 40mg for the first week or lisinopril 5mg for 1 week increasing to 80mg or 10mg, respectively, for 12 weeks. In nonresponders, furosemide was added to monotherapy at 9 weeks. For the primary variable, valsartan 80mg once daily and lisinopril 5/1 Omg once daily successfully reduced sitting diastolic blood pressure from baseline at the 9-week monotherapy end-point (adjusted mean changes −7.97mm Hg and −8.75mm Hg, respectively). The adjusted mean difference between the valsartan and lisinopril treatment groups was 0.77mm Hg and was not statistically significant (95% CI: −1.68, 3.23; p = 0.538). There were similar reductions in sitting systolic blood pressure with both treatments, without any statistically significant difference between the two groups (adjusted mean difference at 9-week end-point: 0.61mm Hg; 95% CI: −3.11, 4.32; p = 0.75). The ratio of geometric mean changes from baseline in glomerular filtration rate (GFR) at 9 weeks was 0.92 and 0.93 for valsartan and lisinopril, respectively. The ratio at 9 weeks in GFR between valsartan and lisinopril was 0.99 (95% CI: 0.96, 1.03) and was not statistically significant (p = 0.612). No significant treatment differences were observed for albumin fractional clearance, IgG fractional clearance or 24-hour urinary protein excretion. Four patients (4.3%) on valsartan and 2 patients (2.1%) on lisinopril reported adverse experiences. Dry cough of moderate severity for one of the patients on lisinopril was the only adverse experience considered to be drug related. The results show valsartan to be as effective as lisinopril in lowering blood pressure and to be well tolerated with no deleterious effects on renal function in hypertensive patients with stable renal insufficiency. | ||
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650 | 4 | |a Serum Uric Acid |7 (dpeaa)DE-He213 | |
650 | 4 | |a Valsartan |7 (dpeaa)DE-He213 | |
700 | 1 | |a Spormann, D. |e verfasserin |4 aut | |
700 | 1 | |a Peruzzi, E. |e verfasserin |4 aut | |
700 | 1 | |a Bodin, F. |e verfasserin |4 aut | |
700 | 1 | |a Sioufi, Antoine |e verfasserin |4 aut | |
700 | 1 | |a Bertocchi, F. |e verfasserin |4 aut | |
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1997 |
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10.2165/00044011-199714040-00002 doi (DE-627)SPR033004447 (SPR)00044011-199714040-00002-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Perico, Norberto verfasserin aut Efficacy and Tolerability of Valsartan Compared with Lisinopril in Patients with Hypertension and Renal Insufficiency 1997 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary This study compared the efficacy and tolerability of valsartan with an angiotensin converting enzyme inhibitor, lisinopril, in hypertensive patients with renal insufficiency. A total of 188 male and female outpatients with stable renal insufficiency [creatinine clearance ($ CL_{CR} $) 20 to 70 ml/min/1.$ 73m^{2} $] were randomised in a 1:1 ratio to receive valsartan or lisinopril in this single-centre, double-blind 13-week trial. Patients were stratified prior to randomisation according to $ CL_{CR} $ — stratum 1: $ CL_{CR} $ 20 to 30 ml/min/1.$ 73m^{2} $; stratum 2: $ CL_{CR} $ 31 to 70 ml/min/1.$ 73m^{2} $. Stratum 1 patients received once-daily valsartan 40mg or lisinopril 2.5mg for 1 week, increasing to 80mg or 5mg, respectively, for 12 weeks. Stratum 2 patients received once-daily valsartan 40mg for the first week or lisinopril 5mg for 1 week increasing to 80mg or 10mg, respectively, for 12 weeks. In nonresponders, furosemide was added to monotherapy at 9 weeks. For the primary variable, valsartan 80mg once daily and lisinopril 5/1 Omg once daily successfully reduced sitting diastolic blood pressure from baseline at the 9-week monotherapy end-point (adjusted mean changes −7.97mm Hg and −8.75mm Hg, respectively). The adjusted mean difference between the valsartan and lisinopril treatment groups was 0.77mm Hg and was not statistically significant (95% CI: −1.68, 3.23; p = 0.538). There were similar reductions in sitting systolic blood pressure with both treatments, without any statistically significant difference between the two groups (adjusted mean difference at 9-week end-point: 0.61mm Hg; 95% CI: −3.11, 4.32; p = 0.75). The ratio of geometric mean changes from baseline in glomerular filtration rate (GFR) at 9 weeks was 0.92 and 0.93 for valsartan and lisinopril, respectively. The ratio at 9 weeks in GFR between valsartan and lisinopril was 0.99 (95% CI: 0.96, 1.03) and was not statistically significant (p = 0.612). No significant treatment differences were observed for albumin fractional clearance, IgG fractional clearance or 24-hour urinary protein excretion. Four patients (4.3%) on valsartan and 2 patients (2.1%) on lisinopril reported adverse experiences. Dry cough of moderate severity for one of the patients on lisinopril was the only adverse experience considered to be drug related. The results show valsartan to be as effective as lisinopril in lowering blood pressure and to be well tolerated with no deleterious effects on renal function in hypertensive patients with stable renal insufficiency. Glomerular Filtration Rate (dpeaa)DE-He213 Adis International Limited (dpeaa)DE-He213 Losartan (dpeaa)DE-He213 Serum Uric Acid (dpeaa)DE-He213 Valsartan (dpeaa)DE-He213 Spormann, D. verfasserin aut Peruzzi, E. verfasserin aut Bodin, F. verfasserin aut Sioufi, Antoine verfasserin aut Bertocchi, F. verfasserin aut Enthalten in Clinical drug investigation Berlin [u.a.] : Springer, 1989 14(1997), 4 vom: Okt., Seite 252-259 (DE-627)327645083 (DE-600)2043793-6 1179-1918 nnns volume:14 year:1997 number:4 month:10 pages:252-259 https://dx.doi.org/10.2165/00044011-199714040-00002 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 14 1997 4 10 252-259 |
spelling |
10.2165/00044011-199714040-00002 doi (DE-627)SPR033004447 (SPR)00044011-199714040-00002-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Perico, Norberto verfasserin aut Efficacy and Tolerability of Valsartan Compared with Lisinopril in Patients with Hypertension and Renal Insufficiency 1997 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary This study compared the efficacy and tolerability of valsartan with an angiotensin converting enzyme inhibitor, lisinopril, in hypertensive patients with renal insufficiency. A total of 188 male and female outpatients with stable renal insufficiency [creatinine clearance ($ CL_{CR} $) 20 to 70 ml/min/1.$ 73m^{2} $] were randomised in a 1:1 ratio to receive valsartan or lisinopril in this single-centre, double-blind 13-week trial. Patients were stratified prior to randomisation according to $ CL_{CR} $ — stratum 1: $ CL_{CR} $ 20 to 30 ml/min/1.$ 73m^{2} $; stratum 2: $ CL_{CR} $ 31 to 70 ml/min/1.$ 73m^{2} $. Stratum 1 patients received once-daily valsartan 40mg or lisinopril 2.5mg for 1 week, increasing to 80mg or 5mg, respectively, for 12 weeks. Stratum 2 patients received once-daily valsartan 40mg for the first week or lisinopril 5mg for 1 week increasing to 80mg or 10mg, respectively, for 12 weeks. In nonresponders, furosemide was added to monotherapy at 9 weeks. For the primary variable, valsartan 80mg once daily and lisinopril 5/1 Omg once daily successfully reduced sitting diastolic blood pressure from baseline at the 9-week monotherapy end-point (adjusted mean changes −7.97mm Hg and −8.75mm Hg, respectively). The adjusted mean difference between the valsartan and lisinopril treatment groups was 0.77mm Hg and was not statistically significant (95% CI: −1.68, 3.23; p = 0.538). There were similar reductions in sitting systolic blood pressure with both treatments, without any statistically significant difference between the two groups (adjusted mean difference at 9-week end-point: 0.61mm Hg; 95% CI: −3.11, 4.32; p = 0.75). The ratio of geometric mean changes from baseline in glomerular filtration rate (GFR) at 9 weeks was 0.92 and 0.93 for valsartan and lisinopril, respectively. The ratio at 9 weeks in GFR between valsartan and lisinopril was 0.99 (95% CI: 0.96, 1.03) and was not statistically significant (p = 0.612). No significant treatment differences were observed for albumin fractional clearance, IgG fractional clearance or 24-hour urinary protein excretion. Four patients (4.3%) on valsartan and 2 patients (2.1%) on lisinopril reported adverse experiences. Dry cough of moderate severity for one of the patients on lisinopril was the only adverse experience considered to be drug related. The results show valsartan to be as effective as lisinopril in lowering blood pressure and to be well tolerated with no deleterious effects on renal function in hypertensive patients with stable renal insufficiency. Glomerular Filtration Rate (dpeaa)DE-He213 Adis International Limited (dpeaa)DE-He213 Losartan (dpeaa)DE-He213 Serum Uric Acid (dpeaa)DE-He213 Valsartan (dpeaa)DE-He213 Spormann, D. verfasserin aut Peruzzi, E. verfasserin aut Bodin, F. verfasserin aut Sioufi, Antoine verfasserin aut Bertocchi, F. verfasserin aut Enthalten in Clinical drug investigation Berlin [u.a.] : Springer, 1989 14(1997), 4 vom: Okt., Seite 252-259 (DE-627)327645083 (DE-600)2043793-6 1179-1918 nnns volume:14 year:1997 number:4 month:10 pages:252-259 https://dx.doi.org/10.2165/00044011-199714040-00002 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 14 1997 4 10 252-259 |
allfields_unstemmed |
10.2165/00044011-199714040-00002 doi (DE-627)SPR033004447 (SPR)00044011-199714040-00002-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Perico, Norberto verfasserin aut Efficacy and Tolerability of Valsartan Compared with Lisinopril in Patients with Hypertension and Renal Insufficiency 1997 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary This study compared the efficacy and tolerability of valsartan with an angiotensin converting enzyme inhibitor, lisinopril, in hypertensive patients with renal insufficiency. A total of 188 male and female outpatients with stable renal insufficiency [creatinine clearance ($ CL_{CR} $) 20 to 70 ml/min/1.$ 73m^{2} $] were randomised in a 1:1 ratio to receive valsartan or lisinopril in this single-centre, double-blind 13-week trial. Patients were stratified prior to randomisation according to $ CL_{CR} $ — stratum 1: $ CL_{CR} $ 20 to 30 ml/min/1.$ 73m^{2} $; stratum 2: $ CL_{CR} $ 31 to 70 ml/min/1.$ 73m^{2} $. Stratum 1 patients received once-daily valsartan 40mg or lisinopril 2.5mg for 1 week, increasing to 80mg or 5mg, respectively, for 12 weeks. Stratum 2 patients received once-daily valsartan 40mg for the first week or lisinopril 5mg for 1 week increasing to 80mg or 10mg, respectively, for 12 weeks. In nonresponders, furosemide was added to monotherapy at 9 weeks. For the primary variable, valsartan 80mg once daily and lisinopril 5/1 Omg once daily successfully reduced sitting diastolic blood pressure from baseline at the 9-week monotherapy end-point (adjusted mean changes −7.97mm Hg and −8.75mm Hg, respectively). The adjusted mean difference between the valsartan and lisinopril treatment groups was 0.77mm Hg and was not statistically significant (95% CI: −1.68, 3.23; p = 0.538). There were similar reductions in sitting systolic blood pressure with both treatments, without any statistically significant difference between the two groups (adjusted mean difference at 9-week end-point: 0.61mm Hg; 95% CI: −3.11, 4.32; p = 0.75). The ratio of geometric mean changes from baseline in glomerular filtration rate (GFR) at 9 weeks was 0.92 and 0.93 for valsartan and lisinopril, respectively. The ratio at 9 weeks in GFR between valsartan and lisinopril was 0.99 (95% CI: 0.96, 1.03) and was not statistically significant (p = 0.612). No significant treatment differences were observed for albumin fractional clearance, IgG fractional clearance or 24-hour urinary protein excretion. Four patients (4.3%) on valsartan and 2 patients (2.1%) on lisinopril reported adverse experiences. Dry cough of moderate severity for one of the patients on lisinopril was the only adverse experience considered to be drug related. The results show valsartan to be as effective as lisinopril in lowering blood pressure and to be well tolerated with no deleterious effects on renal function in hypertensive patients with stable renal insufficiency. Glomerular Filtration Rate (dpeaa)DE-He213 Adis International Limited (dpeaa)DE-He213 Losartan (dpeaa)DE-He213 Serum Uric Acid (dpeaa)DE-He213 Valsartan (dpeaa)DE-He213 Spormann, D. verfasserin aut Peruzzi, E. verfasserin aut Bodin, F. verfasserin aut Sioufi, Antoine verfasserin aut Bertocchi, F. verfasserin aut Enthalten in Clinical drug investigation Berlin [u.a.] : Springer, 1989 14(1997), 4 vom: Okt., Seite 252-259 (DE-627)327645083 (DE-600)2043793-6 1179-1918 nnns volume:14 year:1997 number:4 month:10 pages:252-259 https://dx.doi.org/10.2165/00044011-199714040-00002 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 14 1997 4 10 252-259 |
allfieldsGer |
10.2165/00044011-199714040-00002 doi (DE-627)SPR033004447 (SPR)00044011-199714040-00002-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Perico, Norberto verfasserin aut Efficacy and Tolerability of Valsartan Compared with Lisinopril in Patients with Hypertension and Renal Insufficiency 1997 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary This study compared the efficacy and tolerability of valsartan with an angiotensin converting enzyme inhibitor, lisinopril, in hypertensive patients with renal insufficiency. A total of 188 male and female outpatients with stable renal insufficiency [creatinine clearance ($ CL_{CR} $) 20 to 70 ml/min/1.$ 73m^{2} $] were randomised in a 1:1 ratio to receive valsartan or lisinopril in this single-centre, double-blind 13-week trial. Patients were stratified prior to randomisation according to $ CL_{CR} $ — stratum 1: $ CL_{CR} $ 20 to 30 ml/min/1.$ 73m^{2} $; stratum 2: $ CL_{CR} $ 31 to 70 ml/min/1.$ 73m^{2} $. Stratum 1 patients received once-daily valsartan 40mg or lisinopril 2.5mg for 1 week, increasing to 80mg or 5mg, respectively, for 12 weeks. Stratum 2 patients received once-daily valsartan 40mg for the first week or lisinopril 5mg for 1 week increasing to 80mg or 10mg, respectively, for 12 weeks. In nonresponders, furosemide was added to monotherapy at 9 weeks. For the primary variable, valsartan 80mg once daily and lisinopril 5/1 Omg once daily successfully reduced sitting diastolic blood pressure from baseline at the 9-week monotherapy end-point (adjusted mean changes −7.97mm Hg and −8.75mm Hg, respectively). The adjusted mean difference between the valsartan and lisinopril treatment groups was 0.77mm Hg and was not statistically significant (95% CI: −1.68, 3.23; p = 0.538). There were similar reductions in sitting systolic blood pressure with both treatments, without any statistically significant difference between the two groups (adjusted mean difference at 9-week end-point: 0.61mm Hg; 95% CI: −3.11, 4.32; p = 0.75). The ratio of geometric mean changes from baseline in glomerular filtration rate (GFR) at 9 weeks was 0.92 and 0.93 for valsartan and lisinopril, respectively. The ratio at 9 weeks in GFR between valsartan and lisinopril was 0.99 (95% CI: 0.96, 1.03) and was not statistically significant (p = 0.612). No significant treatment differences were observed for albumin fractional clearance, IgG fractional clearance or 24-hour urinary protein excretion. Four patients (4.3%) on valsartan and 2 patients (2.1%) on lisinopril reported adverse experiences. Dry cough of moderate severity for one of the patients on lisinopril was the only adverse experience considered to be drug related. The results show valsartan to be as effective as lisinopril in lowering blood pressure and to be well tolerated with no deleterious effects on renal function in hypertensive patients with stable renal insufficiency. Glomerular Filtration Rate (dpeaa)DE-He213 Adis International Limited (dpeaa)DE-He213 Losartan (dpeaa)DE-He213 Serum Uric Acid (dpeaa)DE-He213 Valsartan (dpeaa)DE-He213 Spormann, D. verfasserin aut Peruzzi, E. verfasserin aut Bodin, F. verfasserin aut Sioufi, Antoine verfasserin aut Bertocchi, F. verfasserin aut Enthalten in Clinical drug investigation Berlin [u.a.] : Springer, 1989 14(1997), 4 vom: Okt., Seite 252-259 (DE-627)327645083 (DE-600)2043793-6 1179-1918 nnns volume:14 year:1997 number:4 month:10 pages:252-259 https://dx.doi.org/10.2165/00044011-199714040-00002 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 14 1997 4 10 252-259 |
allfieldsSound |
10.2165/00044011-199714040-00002 doi (DE-627)SPR033004447 (SPR)00044011-199714040-00002-e DE-627 ger DE-627 rakwb eng 610 ASE 44.40 bkl Perico, Norberto verfasserin aut Efficacy and Tolerability of Valsartan Compared with Lisinopril in Patients with Hypertension and Renal Insufficiency 1997 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary This study compared the efficacy and tolerability of valsartan with an angiotensin converting enzyme inhibitor, lisinopril, in hypertensive patients with renal insufficiency. A total of 188 male and female outpatients with stable renal insufficiency [creatinine clearance ($ CL_{CR} $) 20 to 70 ml/min/1.$ 73m^{2} $] were randomised in a 1:1 ratio to receive valsartan or lisinopril in this single-centre, double-blind 13-week trial. Patients were stratified prior to randomisation according to $ CL_{CR} $ — stratum 1: $ CL_{CR} $ 20 to 30 ml/min/1.$ 73m^{2} $; stratum 2: $ CL_{CR} $ 31 to 70 ml/min/1.$ 73m^{2} $. Stratum 1 patients received once-daily valsartan 40mg or lisinopril 2.5mg for 1 week, increasing to 80mg or 5mg, respectively, for 12 weeks. Stratum 2 patients received once-daily valsartan 40mg for the first week or lisinopril 5mg for 1 week increasing to 80mg or 10mg, respectively, for 12 weeks. In nonresponders, furosemide was added to monotherapy at 9 weeks. For the primary variable, valsartan 80mg once daily and lisinopril 5/1 Omg once daily successfully reduced sitting diastolic blood pressure from baseline at the 9-week monotherapy end-point (adjusted mean changes −7.97mm Hg and −8.75mm Hg, respectively). The adjusted mean difference between the valsartan and lisinopril treatment groups was 0.77mm Hg and was not statistically significant (95% CI: −1.68, 3.23; p = 0.538). There were similar reductions in sitting systolic blood pressure with both treatments, without any statistically significant difference between the two groups (adjusted mean difference at 9-week end-point: 0.61mm Hg; 95% CI: −3.11, 4.32; p = 0.75). The ratio of geometric mean changes from baseline in glomerular filtration rate (GFR) at 9 weeks was 0.92 and 0.93 for valsartan and lisinopril, respectively. The ratio at 9 weeks in GFR between valsartan and lisinopril was 0.99 (95% CI: 0.96, 1.03) and was not statistically significant (p = 0.612). No significant treatment differences were observed for albumin fractional clearance, IgG fractional clearance or 24-hour urinary protein excretion. Four patients (4.3%) on valsartan and 2 patients (2.1%) on lisinopril reported adverse experiences. Dry cough of moderate severity for one of the patients on lisinopril was the only adverse experience considered to be drug related. The results show valsartan to be as effective as lisinopril in lowering blood pressure and to be well tolerated with no deleterious effects on renal function in hypertensive patients with stable renal insufficiency. Glomerular Filtration Rate (dpeaa)DE-He213 Adis International Limited (dpeaa)DE-He213 Losartan (dpeaa)DE-He213 Serum Uric Acid (dpeaa)DE-He213 Valsartan (dpeaa)DE-He213 Spormann, D. verfasserin aut Peruzzi, E. verfasserin aut Bodin, F. verfasserin aut Sioufi, Antoine verfasserin aut Bertocchi, F. verfasserin aut Enthalten in Clinical drug investigation Berlin [u.a.] : Springer, 1989 14(1997), 4 vom: Okt., Seite 252-259 (DE-627)327645083 (DE-600)2043793-6 1179-1918 nnns volume:14 year:1997 number:4 month:10 pages:252-259 https://dx.doi.org/10.2165/00044011-199714040-00002 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-PHA SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.40 ASE AR 14 1997 4 10 252-259 |
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English |
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Enthalten in Clinical drug investigation 14(1997), 4 vom: Okt., Seite 252-259 volume:14 year:1997 number:4 month:10 pages:252-259 |
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Enthalten in Clinical drug investigation 14(1997), 4 vom: Okt., Seite 252-259 volume:14 year:1997 number:4 month:10 pages:252-259 |
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Glomerular Filtration Rate Adis International Limited Losartan Serum Uric Acid Valsartan |
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Perico, Norberto @@aut@@ Spormann, D. @@aut@@ Peruzzi, E. @@aut@@ Bodin, F. @@aut@@ Sioufi, Antoine @@aut@@ Bertocchi, F. @@aut@@ |
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1997-10-01T00:00:00Z |
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A total of 188 male and female outpatients with stable renal insufficiency [creatinine clearance ($ CL_{CR} $) 20 to 70 ml/min/1.$ 73m^{2} $] were randomised in a 1:1 ratio to receive valsartan or lisinopril in this single-centre, double-blind 13-week trial. Patients were stratified prior to randomisation according to $ CL_{CR} $ — stratum 1: $ CL_{CR} $ 20 to 30 ml/min/1.$ 73m^{2} $; stratum 2: $ CL_{CR} $ 31 to 70 ml/min/1.$ 73m^{2} $. Stratum 1 patients received once-daily valsartan 40mg or lisinopril 2.5mg for 1 week, increasing to 80mg or 5mg, respectively, for 12 weeks. Stratum 2 patients received once-daily valsartan 40mg for the first week or lisinopril 5mg for 1 week increasing to 80mg or 10mg, respectively, for 12 weeks. In nonresponders, furosemide was added to monotherapy at 9 weeks. For the primary variable, valsartan 80mg once daily and lisinopril 5/1 Omg once daily successfully reduced sitting diastolic blood pressure from baseline at the 9-week monotherapy end-point (adjusted mean changes −7.97mm Hg and −8.75mm Hg, respectively). The adjusted mean difference between the valsartan and lisinopril treatment groups was 0.77mm Hg and was not statistically significant (95% CI: −1.68, 3.23; p = 0.538). There were similar reductions in sitting systolic blood pressure with both treatments, without any statistically significant difference between the two groups (adjusted mean difference at 9-week end-point: 0.61mm Hg; 95% CI: −3.11, 4.32; p = 0.75). The ratio of geometric mean changes from baseline in glomerular filtration rate (GFR) at 9 weeks was 0.92 and 0.93 for valsartan and lisinopril, respectively. The ratio at 9 weeks in GFR between valsartan and lisinopril was 0.99 (95% CI: 0.96, 1.03) and was not statistically significant (p = 0.612). No significant treatment differences were observed for albumin fractional clearance, IgG fractional clearance or 24-hour urinary protein excretion. Four patients (4.3%) on valsartan and 2 patients (2.1%) on lisinopril reported adverse experiences. Dry cough of moderate severity for one of the patients on lisinopril was the only adverse experience considered to be drug related. The results show valsartan to be as effective as lisinopril in lowering blood pressure and to be well tolerated with no deleterious effects on renal function in hypertensive patients with stable renal insufficiency.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Glomerular Filtration Rate</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Adis International Limited</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Losartan</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Serum Uric Acid</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Valsartan</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield 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Perico, Norberto ddc 610 bkl 44.40 misc Glomerular Filtration Rate misc Adis International Limited misc Losartan misc Serum Uric Acid misc Valsartan Efficacy and Tolerability of Valsartan Compared with Lisinopril in Patients with Hypertension and Renal Insufficiency |
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610 ASE 44.40 bkl Efficacy and Tolerability of Valsartan Compared with Lisinopril in Patients with Hypertension and Renal Insufficiency Glomerular Filtration Rate (dpeaa)DE-He213 Adis International Limited (dpeaa)DE-He213 Losartan (dpeaa)DE-He213 Serum Uric Acid (dpeaa)DE-He213 Valsartan (dpeaa)DE-He213 |
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Efficacy and Tolerability of Valsartan Compared with Lisinopril in Patients with Hypertension and Renal Insufficiency |
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Perico, Norberto |
doi_str_mv |
10.2165/00044011-199714040-00002 |
dewey-full |
610 |
author2-role |
verfasserin |
title_sort |
efficacy and tolerability of valsartan compared with lisinopril in patients with hypertension and renal insufficiency |
title_auth |
Efficacy and Tolerability of Valsartan Compared with Lisinopril in Patients with Hypertension and Renal Insufficiency |
abstract |
Summary This study compared the efficacy and tolerability of valsartan with an angiotensin converting enzyme inhibitor, lisinopril, in hypertensive patients with renal insufficiency. A total of 188 male and female outpatients with stable renal insufficiency [creatinine clearance ($ CL_{CR} $) 20 to 70 ml/min/1.$ 73m^{2} $] were randomised in a 1:1 ratio to receive valsartan or lisinopril in this single-centre, double-blind 13-week trial. Patients were stratified prior to randomisation according to $ CL_{CR} $ — stratum 1: $ CL_{CR} $ 20 to 30 ml/min/1.$ 73m^{2} $; stratum 2: $ CL_{CR} $ 31 to 70 ml/min/1.$ 73m^{2} $. Stratum 1 patients received once-daily valsartan 40mg or lisinopril 2.5mg for 1 week, increasing to 80mg or 5mg, respectively, for 12 weeks. Stratum 2 patients received once-daily valsartan 40mg for the first week or lisinopril 5mg for 1 week increasing to 80mg or 10mg, respectively, for 12 weeks. In nonresponders, furosemide was added to monotherapy at 9 weeks. For the primary variable, valsartan 80mg once daily and lisinopril 5/1 Omg once daily successfully reduced sitting diastolic blood pressure from baseline at the 9-week monotherapy end-point (adjusted mean changes −7.97mm Hg and −8.75mm Hg, respectively). The adjusted mean difference between the valsartan and lisinopril treatment groups was 0.77mm Hg and was not statistically significant (95% CI: −1.68, 3.23; p = 0.538). There were similar reductions in sitting systolic blood pressure with both treatments, without any statistically significant difference between the two groups (adjusted mean difference at 9-week end-point: 0.61mm Hg; 95% CI: −3.11, 4.32; p = 0.75). The ratio of geometric mean changes from baseline in glomerular filtration rate (GFR) at 9 weeks was 0.92 and 0.93 for valsartan and lisinopril, respectively. The ratio at 9 weeks in GFR between valsartan and lisinopril was 0.99 (95% CI: 0.96, 1.03) and was not statistically significant (p = 0.612). No significant treatment differences were observed for albumin fractional clearance, IgG fractional clearance or 24-hour urinary protein excretion. Four patients (4.3%) on valsartan and 2 patients (2.1%) on lisinopril reported adverse experiences. Dry cough of moderate severity for one of the patients on lisinopril was the only adverse experience considered to be drug related. The results show valsartan to be as effective as lisinopril in lowering blood pressure and to be well tolerated with no deleterious effects on renal function in hypertensive patients with stable renal insufficiency. |
abstractGer |
Summary This study compared the efficacy and tolerability of valsartan with an angiotensin converting enzyme inhibitor, lisinopril, in hypertensive patients with renal insufficiency. A total of 188 male and female outpatients with stable renal insufficiency [creatinine clearance ($ CL_{CR} $) 20 to 70 ml/min/1.$ 73m^{2} $] were randomised in a 1:1 ratio to receive valsartan or lisinopril in this single-centre, double-blind 13-week trial. Patients were stratified prior to randomisation according to $ CL_{CR} $ — stratum 1: $ CL_{CR} $ 20 to 30 ml/min/1.$ 73m^{2} $; stratum 2: $ CL_{CR} $ 31 to 70 ml/min/1.$ 73m^{2} $. Stratum 1 patients received once-daily valsartan 40mg or lisinopril 2.5mg for 1 week, increasing to 80mg or 5mg, respectively, for 12 weeks. Stratum 2 patients received once-daily valsartan 40mg for the first week or lisinopril 5mg for 1 week increasing to 80mg or 10mg, respectively, for 12 weeks. In nonresponders, furosemide was added to monotherapy at 9 weeks. For the primary variable, valsartan 80mg once daily and lisinopril 5/1 Omg once daily successfully reduced sitting diastolic blood pressure from baseline at the 9-week monotherapy end-point (adjusted mean changes −7.97mm Hg and −8.75mm Hg, respectively). The adjusted mean difference between the valsartan and lisinopril treatment groups was 0.77mm Hg and was not statistically significant (95% CI: −1.68, 3.23; p = 0.538). There were similar reductions in sitting systolic blood pressure with both treatments, without any statistically significant difference between the two groups (adjusted mean difference at 9-week end-point: 0.61mm Hg; 95% CI: −3.11, 4.32; p = 0.75). The ratio of geometric mean changes from baseline in glomerular filtration rate (GFR) at 9 weeks was 0.92 and 0.93 for valsartan and lisinopril, respectively. The ratio at 9 weeks in GFR between valsartan and lisinopril was 0.99 (95% CI: 0.96, 1.03) and was not statistically significant (p = 0.612). No significant treatment differences were observed for albumin fractional clearance, IgG fractional clearance or 24-hour urinary protein excretion. Four patients (4.3%) on valsartan and 2 patients (2.1%) on lisinopril reported adverse experiences. Dry cough of moderate severity for one of the patients on lisinopril was the only adverse experience considered to be drug related. The results show valsartan to be as effective as lisinopril in lowering blood pressure and to be well tolerated with no deleterious effects on renal function in hypertensive patients with stable renal insufficiency. |
abstract_unstemmed |
Summary This study compared the efficacy and tolerability of valsartan with an angiotensin converting enzyme inhibitor, lisinopril, in hypertensive patients with renal insufficiency. A total of 188 male and female outpatients with stable renal insufficiency [creatinine clearance ($ CL_{CR} $) 20 to 70 ml/min/1.$ 73m^{2} $] were randomised in a 1:1 ratio to receive valsartan or lisinopril in this single-centre, double-blind 13-week trial. Patients were stratified prior to randomisation according to $ CL_{CR} $ — stratum 1: $ CL_{CR} $ 20 to 30 ml/min/1.$ 73m^{2} $; stratum 2: $ CL_{CR} $ 31 to 70 ml/min/1.$ 73m^{2} $. Stratum 1 patients received once-daily valsartan 40mg or lisinopril 2.5mg for 1 week, increasing to 80mg or 5mg, respectively, for 12 weeks. Stratum 2 patients received once-daily valsartan 40mg for the first week or lisinopril 5mg for 1 week increasing to 80mg or 10mg, respectively, for 12 weeks. In nonresponders, furosemide was added to monotherapy at 9 weeks. For the primary variable, valsartan 80mg once daily and lisinopril 5/1 Omg once daily successfully reduced sitting diastolic blood pressure from baseline at the 9-week monotherapy end-point (adjusted mean changes −7.97mm Hg and −8.75mm Hg, respectively). The adjusted mean difference between the valsartan and lisinopril treatment groups was 0.77mm Hg and was not statistically significant (95% CI: −1.68, 3.23; p = 0.538). There were similar reductions in sitting systolic blood pressure with both treatments, without any statistically significant difference between the two groups (adjusted mean difference at 9-week end-point: 0.61mm Hg; 95% CI: −3.11, 4.32; p = 0.75). The ratio of geometric mean changes from baseline in glomerular filtration rate (GFR) at 9 weeks was 0.92 and 0.93 for valsartan and lisinopril, respectively. The ratio at 9 weeks in GFR between valsartan and lisinopril was 0.99 (95% CI: 0.96, 1.03) and was not statistically significant (p = 0.612). No significant treatment differences were observed for albumin fractional clearance, IgG fractional clearance or 24-hour urinary protein excretion. Four patients (4.3%) on valsartan and 2 patients (2.1%) on lisinopril reported adverse experiences. Dry cough of moderate severity for one of the patients on lisinopril was the only adverse experience considered to be drug related. The results show valsartan to be as effective as lisinopril in lowering blood pressure and to be well tolerated with no deleterious effects on renal function in hypertensive patients with stable renal insufficiency. |
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container_issue |
4 |
title_short |
Efficacy and Tolerability of Valsartan Compared with Lisinopril in Patients with Hypertension and Renal Insufficiency |
url |
https://dx.doi.org/10.2165/00044011-199714040-00002 |
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Spormann, D. Peruzzi, E. Bodin, F. Sioufi, Antoine Bertocchi, F. |
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up_date |
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|
score |
7.399523 |